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https://www.readbyqxmd.com/read/29322560/fast-nonlinear-susceptibility-inversion-with-variational-regularization
#1
Carlos Milovic, Berkin Bilgic, Bo Zhao, Julio Acosta-Cabronero, Cristian Tejos
PURPOSE: Quantitative susceptibility mapping can be performed through the minimization of a function consisting of data fidelity and regularization terms. For data consistency, a Gaussian-phase noise distribution is often assumed, which breaks down when the signal-to-noise ratio is low. A previously proposed alternative is to use a nonlinear data fidelity term, which reduces streaking artifacts, mitigates noise amplification, and results in more accurate susceptibility estimates. We hereby present a novel algorithm that solves the nonlinear functional while achieving computation speeds comparable to those for a linear formulation...
January 10, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29318005/precision-medicine-does-ethnicity-information-complement-genotype-based-prescribing-decisions
#2
REVIEW
Rashmi R Shah, Andrea Gaedigk
Inter-ethnic differences in drug response are all too well known. These are underpinned by a number of factors, including pharmacogenetic differences across various ethnic populations. Precision medicine relies on genotype-based prescribing decisions with the aim of maximizing efficacy and mitigating the risks. When there is no access to genotyping tests, ethnicity is frequently regarded as a proxy of the patient's probable genotype on the basis of overall population-based frequency of genetic variations in the ethnic group the patient belongs to, with some variations being ethnicity-specific...
January 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29315421/development-of-a-new-comprehensive-and-reliable-endometrial-receptivity-map-er-map-er-grade-based-on-rt-qpcr-gene-expression-analysis
#3
M Enciso, J P Carrascosa, J Sarasa, P A Martínez-Ortiz, S Munné, J A Horcajadas, J Aizpurua
STUDY QUESTION: Is it possible to determine the receptivity status of an endometrium by combined quantitative reverse transcription PCR (RT-qPCR) expression analysis of genes involved in endometrial proliferation and immunity? SUMMARY ANSWER: The new ER Map®/ER Grade® test can predict endometrial receptivity status by RT-qPCR using a new panel of genes involved in endometrial proliferation and the maternal immune response associated to embryonic implantation. WHAT IS KNOWN ALREADY: The human endometrium reaches a receptive status adequate for embryonic implantation around Days 19-21 of the menstrual cycle...
January 5, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29284760/the-concept-of-biosimilars-from-characterization-to-evolution-a-narrative-review
#4
REVIEW
Fadi Farhat, Alfredo Torres, Wungki Park, Gilberto de Lima Lopes, Raja Mudad, Chukwuemeka Ikpeazu, Simon Abi Aad
Biologic agents are currently the fastest emerging segment of drug expenditure. Unlike chemically synthesized small-molecule drugs, biologics are more complex, medicinal products produced by a living organism. They have become part of the standard of care in the treatment of a large variety of diseases, such as growth disorders, autoimmune diseases, cancer, cardiovascular illnesses, hemophilia, and rare genetic conditions, to name a few. Biosimilars, which are copies of biologics that are highly similar, were introduced in the market with an aim to offer efficacy that is not clinically different from the originator or reference product, at lower prices...
December 28, 2017: Oncologist
https://www.readbyqxmd.com/read/29259006/consensusdriver-improves-upon-individual-algorithms-for-predicting-driver-alterations-in-different-cancer-types-and-individual-patients
#5
Denis Bertrand, Sibyl Drissler, Burton K Chia, Jia Yu Koh, Chenhao Li, Chayaporn Suphavilai, Iain Beehuat Tan, Niranjan Nagarajan
Existing cancer driver prediction methods are based on very different assumptions and each of them can detect only a particular subset of driver genes. Here we perform a comprehensive assessment of 18 driver prediction methods on more than 3,400 tumor samples from 15 cancer types, all to determine their suitability in guiding precision medicine efforts. We categorized these methods into five groups: functional impact on proteins in general (FI) or specific to cancer (FIC), cohort-based analysis for recurrent mutations (CBA), mutations with expression correlation (MEC), and methods that use gene interaction network-based analysis (INA)...
December 19, 2017: Cancer Research
https://www.readbyqxmd.com/read/29244002/higher-recall-in-metagenomic-sequence-classification-exploiting-overlapping-reads
#6
Samuele Girotto, Matteo Comin, Cinzia Pizzi
BACKGROUND: In recent years several different fields, such as ecology, medicine and microbiology, have experienced an unprecedented development due to the possibility of direct sequencing of microbioimic samples. Among problems that researchers in the field have to deal with, taxonomic classification of metagenomic reads is one of the most challenging. State of the art methods classify single reads with almost 100% precision. However, very often, the performance in terms of recall falls at about 50%...
December 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29230747/-performing-arts-medicine-and-pain-management-in-musicians-in-germany
#7
REVIEW
Elena Romana Gasenzer, Marie Juliane Klumpp, Eberhard Albert Lux, Edmund A Neugebauer
No abstract text is available yet for this article.
December 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/29218868/large-scale-integration-of-heterogeneous-pharmacogenomic-data-for-identifying-drug-mechanism-of-action
#8
Yunan Luo, Sheng Wang, Jinfeng Xiao, Jian Peng
A variety of large-scale pharmacogenomic data, such as perturbation experiments and sensitivity profiles, enable the systematical identification of drug mechanism of actions (MoAs), which is a crucial task in the era of precision medicine. However, integrating these complementary pharmacogenomic datasets is inherently challenging due to the wild heterogeneity, high-dimensionality and noisy nature of these datasets. In this work, we develop Mania, a novel method for the scalable integration of large-scale pharmacogenomic data...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29217935/bronchoscopy-in-nigerian-clinical-practice-a-survey-of-medical-doctors-perception-use-and-associated-challenges
#9
Adekunle Olatayo Adeoti, Olufemi Olumuyiwa Desalu, Joseph Olusesan Fadare, Wemimo Alaofin, Cajetan Chigozie Onyedum
Background: Bronchoscopy is a vital diagnostic and therapeutic procedure in pulmonological practice. The aim of this study was to determine the perception, use and challenges encountered by Nigerian medical doctors involved in this procedure. Materials and Methods: A cross-sectional study was conducted among 250 medical doctors recruited from three major tertiary institutions in Nigeria between September 2013 and June 2014. A semi-structured questionnaire was self-administered to adult physicians, paediatricians, and surgeons as well as their trainees to obtain their perception, use and associated challenges in the use of bronchoscopy in clinical practice...
July 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29176371/percutaneous-image-guided-surgery-training-model-ihu-daicim
#10
Mariano Eduardo Gimenez, Carlos Federico Davrieux, Edgardo Serra, Mariano Palermo, Eduardo Javier Houghton, Pablo Agustin Acquafresca, Bernard Dallemagne, Jung-Myun Kwak, Cristians Alejandro Gonzalez, Jacques Marescaux
The evolution of guided imaging surgery is well known in recent years. As the field of action becomes more specific, learning and teaching are also more specific. State-of-the-art medical training should be mandatory in the field of general medicine and surgery in particular. In this work, we report on how to create a model for the formation of guided surgery by images in a simple and fast way, and its implementation by young surgeons. Pig models have been used in which collections made by bovine small intestine and simulated tumor lesions have been placed...
November 15, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29160495/systemic-arterial-hypertension-in-people-living-with-hiv-aids-integrative-review
#11
Maria Amanda Correia Lima, Gilmara Holanda da Cunha, Marli Teresinha Gimeniz Galvão, Ryvanne Paulino Rocha, Kátia Barbosa Franco, Marina Soares Monteiro Fontenele
OBJECTIVE: To analyze scientific productions about the relationship between HIV and Systemic Arterial Hypertension (SAH) in people living with HIV/AIDS (PLWHA). METHOD: Integrative literature review in six databases, held in March 2016. "AIDS" and "hypertension" were the keywords used in Portuguese, English and Spanish languages. We found 248 articles and selected 17. The categories formulated were "prevalence of SAH in PLWHA," "risk factors for SAH in PLWHA" and "adverse events of antiretroviral therapy (ART) that contribute to HAS...
November 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29159989/general-phase-regularized-reconstruction-using-phase-cycling
#12
Frank Ong, Joseph Y Cheng, Michael Lustig
PURPOSE: To develop a general phase regularized image reconstruction method, with applications to partial Fourier imaging, water-fat imaging and flow imaging. THEORY AND METHODS: The problem of enforcing phase constraints in reconstruction was studied under a regularized inverse problem framework. A general phase regularized reconstruction algorithm was proposed to enable various joint reconstruction of partial Fourier imaging, water-fat imaging and flow imaging, along with parallel imaging (PI) and compressed sensing (CS)...
November 21, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29158712/high-resolution-uhplc-ms-characterization-and-isolation-of-main-compounds-from-the-antioxidant-medicinal-plant-parastrephia-lucida-meyen
#13
Carlos Echiburu-Chau, Leyla Pastén, Claudio Parra, Jorge Bórquez, Andrei Mocan, Mario J Simirgiotis
High-resolution mass spectrometry is currently used to determine the mass of biologically active compounds in medicinal plants and food and UHPLC-Orbitrap is a relatively new technology that allows fast fingerprinting and metabolomics analysis. Forty-two metabolites including several phenolic acids, flavonoids, coumarines, tremetones and ent-clerodane diterpenes were accurately identified for the first time in the resin of the medicinal plant Parastrephia lucida (Asteraceae) a Chilean native species, commonly called umatola, collected in the pre-cordillera and altiplano regions of northern Chile, by means of UHPLC-PDA-HR-MS...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29118777/capparis-spinosa-l-in-a-systematic-review-a-xerophilous-species-of-multi-values-and-promising-potentialities-for-agrosystems-under-the-threat-of-global-warming
#14
REVIEW
Stephanie Chedraoui, Alain Abi-Rizk, Marc El-Beyrouthy, Lamis Chalak, Naim Ouaini, Loïc Rajjou
Caper (Capparis spinosa L.) is a xerophytic shrub with a remarkable adaptability to harsh environments. This plant species is of great interest for its medicinal/pharmacological properties and its culinary uses. Its phytochemical importance relies on many bioactive components present in different organs and its cultivation can be of considerable economic value. Moreover, taxonomic identification of C. spinosa L. has been difficult due to its wide heterogeneity, and many authors fell into confusion due to the scarcity of genetic studies...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29114113/managing-information-in-health-informatics
#15
REVIEW
Rodolfo A Fiorini, Izet Masic
Only once we agree upon our understanding of what words really mean can we debate whether a concept, represented by those words, is or not well represented significantly in specific application. Conceptual clarity and predicative/impredicative competence are the fundamental components for managing information more effectively in Health Informatics, Healthcare and Medicine applications, while promoting innovation and creativity. Medicine was always the art and science of healing. The science became more and more a mechanistic technology in Healthcare; the art was dropped altogether...
September 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/29107981/prevalence-and-risk-factors-of-monochorionic-diamniotic-twinning-after-assisted-reproduction-a-six-year-experience-base-on-a-large-cohort-of-pregnancies
#16
Bing Song, Zhao-Lian Wei, Xiao-Feng Xu, Xue Wang, Xiao-Jin He, Huan Wu, Ping Zhou, Yun-Xia Cao
OBJECTIVE: To characterize the incidence and risk factors for monochorionic diamniotic(MC-DA) twinning after assisted reproductive technologies (ART). DESIGN: Retrospective population-based study. SETTING: The study was conducted in China; Department of Reproductive Medicine Center at The First Affiliated Hospital of Anhui Medical University. POPULATION: A cohort of 8860 clinical pregnancies after embryo transfer (ET) carried out in our center between 2011 and 2016 were retrospectively analyzed for the incidence of MC-DA twinning...
2017: PloS One
https://www.readbyqxmd.com/read/29098342/preoperative-evaluation-of-adult-patients-before-elective-noncardiothoracic-surgery-joint-recommendation-of-the-german-society-of-anesthesiology-and-intensive-care-medicine-the-german-society-of-surgery-and-the-german-society-of-internal-medicine
#17
REVIEW
B Zwissler
Evaluation of the patient's medical history and a physical examination are the cornerstones of risk assessment prior to elective surgery, and may help to optimize the patient's preoperative medical condition and guide perioperative management. Whether performance of additional technical tests (e. g., blood chemistry, electrocardiography, spirometry, chest x‑ray) can contribute to reduction of the perioperative risk is often not well known or controversial. Similarly, there is considerable uncertainty among anesthesiologists, internists, and surgeons with respect to perioperative management of the patient's long-term medication...
November 2, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/29090212/metabolism-of-citrate-and-other-carboxylic-acids-in-erythrocytes-as-a-function-of-oxygen-saturation-and-refrigerated-storage
#18
Travis Nemkov, Kaiqi Sun, Julie A Reisz, Tatsuro Yoshida, Andrew Dunham, Edward Y Wen, Alexander Q Wen, Rob C Roach, Kirk C Hansen, Yang Xia, Angelo D'Alessandro
State-of-the-art proteomics technologies have recently helped to elucidate the unanticipated complexity of red blood cell metabolism. One recent example is citrate metabolism, which is catalyzed by cytosolic isoforms of Krebs cycle enzymes that are present and active in mature erythrocytes and was determined using quantitative metabolic flux analysis. In previous studies, we reported significant increases in glycolytic fluxes in red blood cells exposed to hypoxia in vitro or in vivo, an observation relevant to transfusion medicine owing to the potential benefits associated with hypoxic storage of packed red blood cells...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29024096/state-of-the-art-immunogenicity-evaluation-in-phase-3-confirmatory-study-egality-with-etanercept-biosimilar-gp2015
#19
J Poetzl, I Arlt, O von Richter, H Wöhling, M Afonso, G Schaffar
Immunogenicity is an important aspect of all biologics. Switching between biological products has triggered intensive discussion on the interchangeability of a biosimilar with its reference medicine, with the main focus being immunogenicity and different perspectives within Europe(1) and the United States.(2) Given that immunogenicity assay validation and performance characteristics differ from assay to assay, the immunogenicity assay parameters discussed here enable the interpretation of the immunogenicity results...
October 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29022362/narratives-of-health-and-illness-arts-based-research-capturing-the-lived-experience-of-dementia
#20
Hilary Moss, Desmond O'Neill
Introduction This paper presents three artists' residencies in a geriatric medicine unit in a teaching hospital. The aim of the residencies was creation of new work of high artistic quality reflecting the lived experience of the person with dementia and greater understanding of service user experience of living with dementia. This paper also explores arts-based research methodologies in a medical setting. Method Arts-based research and narrative enquiry were the method used in this study. Artists had extensive access to service users with dementia, family carers and clinical team...
January 1, 2017: Dementia
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