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https://www.readbyqxmd.com/read/28733975/deep-convolutional-neural-network-and-3d-deformable-approach-for-tissue-segmentation-in-musculoskeletal-magnetic-resonance-imaging
#1
Fang Liu, Zhaoye Zhou, Hyungseok Jang, Alexey Samsonov, Gengyan Zhao, Richard Kijowski
PURPOSE: To describe and evaluate a new fully automated musculoskeletal tissue segmentation method using deep convolutional neural network (CNN) and three-dimensional (3D) simplex deformable modeling to improve the accuracy and efficiency of cartilage and bone segmentation within the knee joint. METHODS: A fully automated segmentation pipeline was built by combining a semantic segmentation CNN and 3D simplex deformable modeling. A CNN technique called SegNet was applied as the core of the segmentation method to perform high resolution pixel-wise multi-class tissue classification...
July 21, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28722180/a-generic-tg-186-shielded-applicator-for-commissioning-model-based-dose-calculation-algorithms-for-high-dose-rate-192-ir-brachytherapy
#2
Yunzhi Ma, Javier Vijande, Facundo Ballester, Åsa Carlsson Tedgren, Domingo Granero, Annette Haworth, Firas Mourtada, Gabriel Paiva Fonseca, Kyveli Zourari, Panagiotis Papagiannis, Mark J Rivard, Frank André Siebert, Ron S Sloboda, Ryan Smith, Marc J P Chamberland, Rowan M Thomson, Frank Verhaegen, Luc Beaulieu
PURPOSE: A joint working group was created by the American Association of Physicists in Medicine (AAPM), the European Society for Radiotherapy and Oncology (ESTRO), and the Australasian Brachytherapy Group (ABG) with the charge, among others, to develop a set of well-defined test case plans and perform model-based dose calculation algorithms (MBDCA) dose calculations and comparisons. Its main goal is to facilitate a smooth transition from the AAPM Task Group No. 43 (TG-43) dose calculation formalism, widely being used in clinical practice for brachytherapy, to the one proposed by Task Group No...
July 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28715343/deep-belief-networks-for-electroencephalography-a-review-of-recent-contributions-and-future-outlooks
#3
Faezeh Movahedi, James L Coyle, Ervin Sejdic
Deep learning, a relatively new branch of machine learning, has been investigated for use in a variety of biomedical applications. Deep learning algorithms have been used to analyze different physiological signals and gain a better understanding of human physiology for automated diagnosis of abnormal conditions. In this manuscript, we provide an overview of deep learning approaches with a focus on deep belief networks in electroencephalography applications. We investigate the state of- the-art algorithms for deep belief networks and then cover the application of these algorithms and their performances in electroencephalographic applications...
July 14, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28692606/occupational-health-and-the-performing-arts-an-introduction
#4
David Hinkamp, Jennie Morton, Donna H Krasnow, Mary Virginia Wilmerding, William J Dawson, Michael G Stewart, Herbert Steven Sims, Jan Potter Reed, Katherine Duvall, Michael McCann
OBJECTIVE: Workplace hazards in the performing arts cause injuries, disabilities, and deaths every year. Occupational health professionals are familiar with most of these hazards and are particularly qualified to contribute to efforts to reduce them. This article reviews current health issues in the performing arts and highlights opportunities for occupational health contributions. METHODS: Recognized experts in performing arts medicine were consulted and articles illustrating performing arts health issues were reviewed...
July 7, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28691437/hiv-misdiagnosis-in-sub-saharan-africa-performance-of-diagnostic-algorithms-at-six-testing-sites
#5
REVIEW
Cara S Kosack, Leslie Shanks, Greet Beelaert, Tumwesigye Benson, Aboubacar Savane, Anne Ng'ang'a, Bita Andre, Jean-Paul Bn Zahinda, Katrien Fransen, Anne-Laure Page
INTRODUCTION: We evaluated the diagnostic accuracy of HIV testing algorithms at six programmes in five sub-Saharan African countries. METHODS: In this prospective multisite diagnostic evaluation study (Conakry, Guinea; Kitgum, Uganda; Arua, Uganda; Homa Bay, Kenya; Doula, Cameroun and Baraka, Democratic Republic of Congo), samples from clients (greater than equal to five years of age) testing for HIV were collected and compared to a state-of-the-art algorithm from the AIDS reference laboratory at the Institute of Tropical Medicine, Belgium...
July 3, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28679938/managing-information-more-effectively-in-health-informatics-applications
#6
Rodolfo A Fiorini
Conceptual clarity and predicative/impredicative competence are the fundamental components for managing information more effectively in Health Informatics, Healthcare and Medicine applications, while promoting innovation and creativity. Medicine was always the art and science of healing. The science became more and more a mechanistic technology in Healthcare; the art was dropped altogether. But uncertainty-as-problem in the past is slowly morphing into the evolutive concept of uncertainty-as-resource. The key change performance factor is education, distinguishing building on sand from building on rock for Health Informatics! Conceptual clarity, more than instrumental obsession (so typical of this particular time) is necessary...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28679933/health-informatics-and-wellbeing-by-enhanced-knowledge-formalisation
#7
Rodolfo A Fiorini
Only once we agree upon our understanding of what words really mean can we debate whether a concept, represented by those words, is or not well represented significantly in specific application. In a previous paper we presented an innovative point of view on deeper wellbeing understanding towards its increased, effective Health Informatics and clinical usage and applications. Medicine was always the art and science of healing. The science became more and more a mechanistic technology; the art was dropped altogether...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28678064/who-makes-it-to-the-end-a-novel-predictive-model-for-identifying-surgical-residents-at-risk-for-attrition
#8
Heather L Yeo, Jonathan S Abelson, Jialin Mao, Frank Lewis, Fabrizio Michelassi, Richard Bell, Art Sedrakyan, Julie A Sosa
OBJECTIVE: We present 8-year follow-up data from the intern class of 2007 to 2008 using a novel, nonparametric predictive model to identify those residents who are at greatest risk of not completing their training. BACKGROUND: Nearly 1 in every 4 categorical general surgery residents does not complete training. There has been no study at a national level to identify individual resident and programmatic factors that can be used to accurately anticipate which residents are most at risk of attrition out...
July 3, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28666440/do-medical-students-and-young-physicians-assess-reliably-their-self-efficacy-regarding-communication-skills-a-prospective-study-from-end-of-medical-school-until-end-of-internship
#9
Tore Gude, Arnstein Finset, Tor Anvik, Anders Bærheim, Ole Bernt Fasmer, Hilde Grimstad, Per Vaglum
BACKGROUND: This prospective study from end of medical school through internship investigates the course and possible change of self- reported self-efficacy in communication skills compared with observers' ratings of such skills in consultations with simulated patients. METHODS: Sixty-two medical students (43 females) from four Norwegian universities performed a videotaped consultation with a simulated patient immediately before medical school graduation (T1) and after internship (internal medicine, surgery and family medicine, half a year each - T2)...
June 30, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28657444/bridging-the-gap-for-lipid-lowering-therapy-plaque-regression-coronary-computed-tomographic-angiography-and-imaging-guided-personalized-medicine
#10
Alan C Kwan, Konstantinos N Aronis, Veit Sandfort, Roger S Blumenthal, David A Bluemke
Lipid-lowering therapy effectively decreases cardiovascular risk on a population level, but it remains difficult to identify an individual patient's personal risk reduction while following guideline directed medical therapy, leading to overtreatment in some patients and cardiovascular events in others. Recent improvements in cardiac CT technology provide the ability to directly assess an individual's atherosclerotic disease burden, which has the potential to personalize risk assessment for lipid-lowering therapy...
July 6, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28638442/computational-dynamic-approaches-for-temporal-omics-data-with-applications-to-systems-medicine
#11
REVIEW
Yulan Liang, Arpad Kelemen
Modeling and predicting biological dynamic systems and simultaneously estimating the kinetic structural and functional parameters are extremely important in systems and computational biology. This is key for understanding the complexity of the human health, drug response, disease susceptibility and pathogenesis for systems medicine. Temporal omics data used to measure the dynamic biological systems are essentials to discover complex biological interactions and clinical mechanism and causations. However, the delineation of the possible associations and causalities of genes, proteins, metabolites, cells and other biological entities from high throughput time course omics data is challenging for which conventional experimental techniques are not suited in the big omics era...
2017: BioData Mining
https://www.readbyqxmd.com/read/28632645/management-of-symptomatic-lumbar-disk-herniation-an-international-perspective
#12
Pravesh S Gadjradj, Mark P Arts, Maurits W van Tulder, Wim J R Rietdijk, Wilco C Peul, Biswadjiet S Harhangi
STUDY DESIGN: A questionnaire survey. OBJECTIVE: To evaluate the current practice patterns of surgeons regarding both the surgical and nonsurgical management of lumbar disk herniation (LDH) worldwide and to compare this with the current literature. SUMMARY OF BACKGROUND DATA: Sciatica is a common diagnosis in the general population. Sciatica is most frequently caused by LDH. Multiple surgical techniques and treatment modalities are available to treat LDH, albeit some with small effect sizes or without compelling evidence...
June 19, 2017: Spine
https://www.readbyqxmd.com/read/28629126/differentiated-thyroid-cancer-treatment-state-of-the-art
#13
REVIEW
Benedikt Schmidbauer, Karin Menhart, Dirk Hellwig, Jirka Grosse
Differentiated thyroid cancer (DTC) is a rare malignant disease, although its incidence has increased over the last few decades. It derives from follicular thyroid cells. Generally speaking, the prognosis is excellent. If treatment according to the current guidelines is given, cases of recurrence or persistence are rare. DTC requires special expertise by the treating physician. In recent years, new therapeutic options for these patients have become available. For this article we performed a systematic literature review with special focus on the guidelines of the American Thyroid Association, the European Association of Nuclear Medicine, and the German Society of Nuclear Medicine...
June 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28606763/application-of-eye-tracking-in-medicine-a-survey-research-issues-and-challenges
#14
Katarzyna Harezlak, Pawel Kasprowski
The performance and quality of medical procedures and treatments are inextricably linked to technological development. The application of more advanced techniques provides the opportunity to gain wider knowledge and deeper understanding of the human body and mind functioning. The eye tracking methods used to register eye movement to find the direction and targets of a person's gaze are well in line with the nature of the topic. By providing methods for capturing and processing images of the eye it has become possible not only to reveal abnormalities in eye functioning but also to conduct cognitive studies focused on learning about peoples' emotions and intentions...
May 30, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28605458/prioritizing-tests-of-epistasis-through-hierarchical-representation-of-genomic-redundancies
#15
Tyler Cowman, Mehmet Koyutürk
Epistasis is defined as a statistical interaction between two or more genomic loci in terms of their association with a phenotype of interest. Epistatic loci that are identified using data from Genome-Wide Association Studies (GWAS) provide insights into the interplay among multiple genetic factors, with applications including assessment of susceptibility to complex diseases, decision making in precision medicine, and gaining insights into disease mechanisms. Since the number of genomic loci assayed by GWAS is extremely large (usually in the order of millions), identification of epistatic loci is a statistically difficult and computationally intensive problem...
June 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28599011/medicine-performing-arts-and-science-dancing-to-the-same-tune
#16
EDITORIAL
Bronwen J Ackermann
A substantial period of time has been spent developing rigorous quantitative scientific approaches to inform medical practice (evidence-based practice). While this process has been important for many medical breakthroughs, and continues to play a critical role in medical and scientific research, it was felt to cause a medical shift away from the individual patient, as practitioners focussed more on the method of practice than the person themselves. However, following this period when a preponderance of attention was paid to quantitative studies, the tide has now turned back to integrating this knowledge with the clinical skills and expertise of medical practitioners...
June 2017: Medical Problems of Performing Artists
https://www.readbyqxmd.com/read/28592365/assisted-baseline-subtraction-in-complex-chromatograms-using-the-beads-algorithm
#17
J A Navarro-Huerta, J R Torres-Lapasió, S López-Ureña, M C García-Alvarez-Coque
The data processing step of complex signals in high-performance liquid chromatography may constitute a bottleneck to obtain significant information from chromatograms. Data pre-processing should be preferably done with little (or no) user supervision, for a maximal benefit and highest speed. In this work, a tool for the configuration of a state-of-the-art baseline subtraction algorithm, called BEADS (Baseline Estimation And Denoising using Sparsity) is developed and verified. A quality criterion based on the measurement of the autocorrelation level was designed to select the most suitable working parameters to obtain the best baseline...
May 29, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28588979/determinants-of-adherence-to-antiretroviral-therapy-among-hiv-positive-adults-in-sub-saharan-africa-a-systematic-review
#18
Tessa Heestermans, Joyce L Browne, Susan C Aitken, Sigrid C Vervoort, Kerstin Klipstein-Grobusch
OBJECTIVE: The rapid scale up of antiretroviral treatment (ART) in sub-Saharan Africa (SSA) has resulted in an increased focus on patient adherence. Non-adherence can lead to drug-resistant HIV caused by failure to achieve maximal viral suppression. Optimal treatment requires the identification of patients at high risk of suboptimal adherence and targeted interventions. The aim of this review was to identify and summarise determinants of adherence to ART among HIV-positive adults. DESIGN: Systematic review of adherence to ART in SSA from January 2002 to October 2014...
November 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28575906/-preoperative-evaluation-of-adult-patients-before-elective-non-cardiothoracic-surgery
#19
(no author information available yet)
Evaluation of the patient's medical history and a physical examination are the cornerstones of risk assessment prior to elective surgery and may help to optimize the patient's preoperative medical condition and to guide perioperative management. Whether the performance of additional technical tests (e.g. blood chemistry, ECG, spirometry, chest x-ray) can contribute to a reduction of perioperative risk is often not very well known or controversial. Similarly, there is considerable uncertainty among anaesthesiologists, internists and surgeons with respect to the perioperative management of the patient's long-term medication...
June 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28573343/-preoperative-evaluation-of-adult-patients-before-elective-noncardiothoracic-surgery-joint-recommendation-of-the-german-society-of-anesthesiology-and-intensive-care-medicine-the-german-society-of-surgery-and-the-german-society-of-internal-medicine
#20
B Zwissler
Evaluation of the patient's medical history and a physical examination are the cornerstones of risk assessment prior to elective surgery and may help to optimize the patient's preoperative medical condition and to guide perioperative management. Whether the performance of additional technical tests (e. g. blood chemistry, ECG, spirometry, chest x‑ray) can contribute to a reduction of perioperative risk is often not very well known or is controversial. Similarly, there is considerable uncertainty among anesthesiologists, internists and surgeons with respect to the perioperative management of the patient's long-term medication...
June 2017: Der Anaesthesist
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