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https://www.readbyqxmd.com/read/27933280/bone-imaging-in-prostate-cancer-the-evolving-roles-of-nuclear-medicine-and-radiology
#1
REVIEW
Gary J R Cook, Gurdip Azad, Anwar R Padhani
The bone scan continues to be recommended for both the staging and therapy response assessment of skeletal metastases from prostate cancer. However, it is widely recognised that bone scans have limited sensitivity for disease detection and is both insensitive and non-specific for determining treatment response, at an early enough time point to be clinically useful. We, therefore, review the evolving roles of nuclear medicine and radiology for this application. We have reviewed the published literature reporting recent developments in imaging bone metastases in prostate cancer, and provide a balanced synopsis of the state of the art...
2016: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27902695/text-mining-genotype-phenotype-relationships-from-biomedical-literature-for-database-curation-and-precision-medicine
#2
Ayush Singhal, Michael Simmons, Zhiyong Lu
The practice of precision medicine will ultimately require databases of genes and mutations for healthcare providers to reference in order to understand the clinical implications of each patient's genetic makeup. Although the highest quality databases require manual curation, text mining tools can facilitate the curation process, increasing accuracy, coverage, and productivity. However, to date there are no available text mining tools that offer high-accuracy performance for extracting such triplets from biomedical literature...
November 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27901055/mediboost-a-patient-stratification-tool-for-interpretable-decision-making-in-the-era-of-precision-medicine
#3
Gilmer Valdes, José Marcio Luna, Eric Eaton, Charles B Simone, Lyle H Ungar, Timothy D Solberg
Machine learning algorithms that are both interpretable and accurate are essential in applications such as medicine where errors can have a dire consequence. Unfortunately, there is currently a tradeoff between accuracy and interpretability among state-of-the-art methods. Decision trees are interpretable and are therefore used extensively throughout medicine for stratifying patients. Current decision tree algorithms, however, are consistently outperformed in accuracy by other, less-interpretable machine learning models, such as ensemble methods...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27860546/transcatheter-aortic-valve-replacement-state-of-the-art-and-future-directions
#4
Mackram F Eleid, David R Holmes
Transcatheter aortic valve replacement (TAVR) is a transformational and rapidly evolving treatment for patients with aortic stenosis who require valve replacement. Novel technological advancements have made this percutaneous minimally invasive therapy a first-line treatment for many patients at extreme risk for conventional cardiac surgery. New devices and improvements in existing devices have reduced procedural complications, and scientific trials are investigating the role of TAVR in lower-risk aortic stenosis populations, in patients with aortic regurgitation, and in patients with bicuspid aortic valve disease...
November 14, 2016: Annual Review of Medicine
https://www.readbyqxmd.com/read/27859563/direct-estimation-of-tracer-kinetic-parameter-maps-from-highly-undersampled-brain-dynamic-contrast-enhanced-mri
#5
Yi Guo, Sajan Goud Lingala, Yinghua Zhu, R Marc Lebel, Krishna S Nayak
PURPOSE: The purpose of this work was to develop and evaluate a T1 -weighted dynamic contrast enhanced (DCE) MRI methodology where tracer-kinetic (TK) parameter maps are directly estimated from undersampled (k,t)-space data. THEORY AND METHODS: The proposed reconstruction involves solving a nonlinear least squares optimization problem that includes explicit use of a full forward model to convert parameter maps to (k,t)-space, utilizing the Patlak TK model. The proposed scheme is compared against an indirect method that creates intermediate images by parallel imaging and compressed sensing before to TK modeling...
November 17, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27826479/intralipotherapy-the-state-of-the-art
#6
Roberto Amore, Hernán Pinto, Kostas Gritzalas, Carlota Hernández, Katarzyna Skwara-Guzikowska, Domenico Amuso, Vincenza Leonardi
BACKGROUND: Reconstruction intralipotherapy is a term commonly used in the field of aesthetic medicine, above all in Europe, which defines a specific injection technique developed for the treatment of localized fat with substances that provoke the lysis of adipocytes by means of an injection directly into the adipose tissue with a long needle. The aim of this study is to define the technique in detail and everything that is associated with it, on the basis of years of multicenter experience by doctors who perform it...
October 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27809920/assisted-reproductive-technology-pregnancy-complications-are-significantly-associated-with-endometriosis-severity-before-conception-a-retrospective-cohort-study
#7
Tatsuya Fujii, Osamu Wada-Hiraike, Takeshi Nagamatsu, Miyuki Harada, Tetsuya Hirata, Kaori Koga, Tomoyuki Fujii, Yutaka Osuga
BACKGROUND: Endometriosis has been shown to be associated with second- to third-trimester pregnancy complications such as preterm birth and placenta previa, but the evidence is inconsistent. We hypothesized that endometriosis severity might affect these inconsistent results. Therefore we aimed to conduct a retrospective cohort study to elucidate whether endometriosis severity is associated with the incidence rates of adverse pregnancy outcomes. METHODS: The patients who achieved singleton pregnancy by assisted reproductive technology (ART) in our facility between March 2000 and December 2014 (N = 631) were included in this analysis...
November 3, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27801973/scai-ccas-spa-expert-consensus-statement-for-anesthesia-and-sedation-practice-recommendations-for-patients-undergoing-diagnostic-and-therapeutic-procedures-in-the-pediatric-and-congenital-cardiac-catheterization-laboratory
#8
Kirsten C Odegard, Robert Vincent, Rahul Baijal, SuAnne Daves, Robert Gray, Alex Javois, Barry Love, Phil Moore, David Nykanen, Lori Riegger, Scott G Walker, Elizabeth C Wilson
Current practice of sedation and anesthesia for patients undergoing pediatric congenital cardiac catheterization laboratory (PCCCL) procedures is known to vary among institutions, a multi-society expert panel with representatives from the Congenital Heart Disease Council of the Society for Cardiovascular Angiography and Interventions (SCAI), the Society for Pediatric Anesthesia (SPA) and the Congenital Cardiac Anesthesia Society (CCAS) was convened to evaluate the types of sedation and personnel necessary for procedures performed in the PCCCL...
November 1, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27788041/fetal-dysmorphology-still-an-essential-art-analysis-of-the-limitations-of-microarray-in-a-fetal-population-and-a-look-toward-the-genome-sequencing-era
#9
Elaine Fletcher, Mary Porteous, Eddy Maher, Kathryn J McKenzie, Margaret J Evans
Cytogenomic microarray allows assessment of the genome at higher resolutions than traditional karyotyping. The objective of this study is to evaluate the utility of microarray in a routine fetal autopsy setting before the advent of routine fetal exome / genome sequencing and the issues these technologies may generate. A systematic review of fetal post mortems performed between Jan 2011 - Dec 2014 was undertaken. Cases where there was no consent for audit, research or genetic testing were excluded as were cases referred to the Procurator Fiscal, stillbirths and neonatal deaths...
October 27, 2016: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/27749349/scai-ccas-spa-expert-consensus-statement-for-anesthesia-and-sedation-practice-recommendations-for-patients-undergoing-diagnostic-and-therapeutic-procedures-in-the-pediatric-and-congenital-cardiac-catheterization-laboratory
#10
Kirsten C Odegard, Robert Vincent, Rahul G Baijal, Suanne M Daves, Robert G Gray, Alexander J Javois, Barry A Love, Philip Moore, David Nykanen, Lori Q Riegger, Scott G Walker, Elizabeth C Wilson
Current practice of sedation and anesthesia for patients undergoing pediatric and congenital cardiac catheterization laboratory (PCCCL) procedures is known to vary among institutions, a multi-society expert panel with representatives from the Congenital Heart Disease Council of the Society for Cardiovascular Angiography and Interventions, the Society for Pediatric Anesthesia and the Congenital Cardiac Anesthesia Society was convened to evaluate the types of sedation and personnel necessary for procedures performed in the PCCCL...
November 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27738432/biological-effects-of-medicinal-plants-on-induced-periodontitis-a-systematic-review
#11
Jefferson Soares de Oliveira, Moara E Silva Conceição Pinto, Lucas de Araújo de Bastos Santana, Antonione Santos Bezerra Pinto, David di Lenardo, Daniel Fernando Pereira Vasconcelos
Objective. The aim of this systematic review was to investigate the advances in the study of medicinal plants and their biologic effects on periodontitis in animal models. Study Design. A systematic search was conducted by three independent researchers, who screened articles published up to March/2016, to identify the studies that contained sufficient and clear information on the association of the medicinal plants and periodontitis in murine models. The searches were performed using PubMed, Cochrane, and Science Direct databases...
2016: International Journal of Dentistry
https://www.readbyqxmd.com/read/27709725/exploring-canadian-surgeons-decisions-about-postoperative-weight-bearing-for-their-hip-fracture-patients
#12
Leslie Carlin, Kathryn Sibley, Richard Jenkinson, Pia Kontos, Rhona McGlasson, Hans J Kreder, Susan Jaglal
For older adults with osteoporosis, a fall resulting in hip fracture is a life-changing event from which only one-third fully recover. Current best evidence argues strongly for elderly patients to bear weight on their repaired hip fracture immediately after their surgery to maximize their chances of full or nearly full recovery. Patient stakeholders in Canada have argued that some surgeons fail to issue "weight-bearing-as-tolerated" (WBAT) orders in all eligible cases, protecting their bony repair but contributing to increased mortality and long-term disability rates...
October 6, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27705919/exploring-timing-activation-of-functional-pathway-based-on-differential-co-expression-analysis-in-preimplantation-embryogenesis
#13
Yongchun Zuo, Guanghua Su, Shanshan Wang, Lei Yang, Mingzhi Liao, Zhuying Wei, Chunling Bai, Guangpeng Li
Recent genome-wide omics studies have confirmed the early embryogenesis strictly dependent on the rigorous spatiotemporal activation and multilevel regulation. However, the full effect of functional pathway was not considered. To obtain complete understanding of the gene activation during early development, we performed systematic comparisons based on differential co-expression analysis for bovine preimplantation embryo development (PED). The results confirmed that the functional pathways actively transcribes as early as the 2-cell and 4-cell waves, which Basal transcription factor, Endocytosis and Spliceosome pathway can represent first signs of embryonic activity...
September 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27676949/martials-arts-use-in-physical-and-rehabilitation-medicine-literature-review-and-perspectives
#14
Duong-Minh Nguyen, Isabelle Laffont, Arnaud Dupeyron
OBJECTIVE: Martial arts are physical and meditative discipline available as complementary strategies able to improve functional capacity, physical performances, postural control of patients suffering from chronical diseases. They can probably slow their clinical evolution. The objective of this communication is a review of the literature about the effects of martial arts training into a said chronical disease. MATERIAL/PATIENTS AND METHODS: A literature research in PubMed and Pedro databases was performed with the following keywords: martial arts, rehabilitation, chronic disease, neurologic disorders, heart disease, chronic obstructive pulmonary disease, musculo-squelettal disorders, low back pain...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27651724/a-novel-approach-using-a-minimal-number-of-injections-during-the-ivf-icsi-cycle-luteal-half-dose-depot-gnrh-agonist-following-corifollitropin-alfa-versus-the-corifollitropin-alfa-with-a-gnrh-antagonist-cycle
#15
Bülent Haydardedeoğlu, Esra Bulgan Kılıçdağ
OBJECTIVE: Corifollitropin alfa is a good choice for assisted reproductive technology (ART) cycles because fewer injections are needed than with other agents. In this retrospective cohort, we analyzed luteal injected half-dose depot gonadotropin hormone-releasing hormone (GnRH) agonist cycles in women who received corifollitropin alfa and those who underwent a conventional corifollitropin alfa cycle with a GnRH antagonist. MATERIAL AND METHODS: In this retrospective cohort, we analyzed luteal injected half-dose depot GnRH agonist cycles in women who received corifollitropin alfa and those who underwent a conventional corifollitropin alfa cycle with a GnRH antagonist at the Division of Reproductive Endocrinology and IVF Unit, Obstetrics and Gynecology Department, Başkent University School of Medicine, Adana, Turkey, from March 2014 to August 2015...
2016: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/27645583/a-systematic-review-on-phenolic-compounds-in-passiflora-plants-exploring-biodiversity-for-food-nutrition-and-popular-medicine
#16
Izabel Lucena Gadioli, Marcela de Sá Barreto da Cunha, Mariana Veras Oliveira de Carvalho, Ana Maria Costa, Lívia de Lacerda de Oliveira Pineli
Passiflora plants are strategic in the context of biodiversity for food and nutrition. We applied the procedures of a systematic review protocol to study the state of the art on identification of phenolic compounds from Passiflora plants. An automated literature search was conducted using six databases and a combination of seven keywords. All the analytical, chromatographic, and spectroscopic methods were included. The studies were classified according to their method of identification, phenolic classes, and method of extraction...
September 19, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27642271/metabolomics-enables-precision-medicine-a-white-paper-community-perspective
#17
Richard D Beger, Warwick Dunn, Michael A Schmidt, Steven S Gross, Jennifer A Kirwan, Marta Cascante, Lorraine Brennan, David S Wishart, Matej Oresic, Thomas Hankemeier, David I Broadhurst, Andrew N Lane, Karsten Suhre, Gabi Kastenmüller, Susan J Sumner, Ines Thiele, Oliver Fiehn, Rima Kaddurah-Daouk
INTRODUCTION BACKGROUND TO METABOLOMICS: Metabolomics is the comprehensive study of the metabolome, the repertoire of biochemicals (or small molecules) present in cells, tissues, and body fluids. The study of metabolism at the global or "-omics" level is a rapidly growing field that has the potential to have a profound impact upon medical practice. At the center of metabolomics, is the concept that a person's metabolic state provides a close representation of that individual's overall health status...
2016: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/27612449/a-hybrid-computational-strategy-to-address-wgs-variant-analysis-in-5000-samples
#18
Zhuoyi Huang, Navin Rustagi, Narayanan Veeraraghavan, Andrew Carroll, Richard Gibbs, Eric Boerwinkle, Manjunath Gorentla Venkata, Fuli Yu
BACKGROUND: The decreasing costs of sequencing are driving the need for cost effective and real time variant calling of whole genome sequencing data. The scale of these projects are far beyond the capacity of typical computing resources available with most research labs. Other infrastructures like the cloud AWS environment and supercomputers also have limitations due to which large scale joint variant calling becomes infeasible, and infrastructure specific variant calling strategies either fail to scale up to large datasets or abandon joint calling strategies...
September 10, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27575296/in-the-september-issue
#19
EDITORIAL
Donna Krasnow
It is undeniable that the research and clinical knowledge base in performing arts medicine continues to develop, as discussed in the June editorial in Medical Problems of Performing Artists. This growth in research is certainly evident in dance, as in other areas of the performing arts. The breadth of the research includes the studies of biomechanics, conditioning and supplementary training practices, injury prevention and rehabilitation, motor control, nutrition, physics, and psychology.
September 2016: Medical Problems of Performing Artists
https://www.readbyqxmd.com/read/27565795/mraise-an-alternative-algorithmic-approach-to-ligand-based-virtual-screening
#20
Mathias M von Behren, Stefan Bietz, Eva Nittinger, Matthias Rarey
Ligand-based virtual screening is a well established method to find new lead molecules in todays drug discovery process. In order to be applicable in day to day practice, such methods have to face multiple challenges. The most important part is the reliability of the results, which can be shown and compared in retrospective studies. Furthermore, in the case of 3D methods, they need to provide biologically relevant molecular alignments of the ligands, that can be further investigated by a medicinal chemist. Last but not least, they have to be able to screen large databases in reasonable time...
August 2016: Journal of Computer-aided Molecular Design
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