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Indirect Aggression

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https://www.readbyqxmd.com/read/29661963/obesity-suppresses-tumor-attributable-psa-affecting-risk-categorization
#1
Ken Chow, Stefano Mangiola, Jaideep Vazirani, Justin S Peters, Anthony J Costello, Christopher M Hovens, Niall M Corcoran
Obesity is linked with more aggressive prostate cancer and higher rates of disease recurrence post treatment. It is unclear if this is due to specific tumor-promoting effects of obesity or diagnostic bias. Patients undergoing prostatectomy were categorized according to their body mass index (BMI). Expected prostate-specific antigen (PSA) levels were calculated for each patient based on tumor characteristics. The effect of obesity on the accuracy of pre-treatment risk categorization was determined, and mediation analysis was used to identify the contribution of biologic vs non-biologic mechanisms to the observed increased risk of biochemical recurrence...
May 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29659017/experiences-of-physical-and-relational-victimization-in-children-with-adhd-the-role-of-social-problems-and-aggression
#2
Julia D McQuade, Nicole L Breslend, Destin Groff
The social risk factors for physical and relational peer victimization were examined within a mixed-gender sample of children with and without attention-deficit/hyperactivity disorder (ADHD). Participants were 124 children (ages 8-12 years; 48% boys), with 47% exhibiting sub-clinical or clinical elevations in ADHD symptoms. ADHD and oppositional defiant disorder (ODD) symptom counts were assessed based on parent- and teacher-reports; parents rated children's social problems and teachers rated children's use of physical and relational aggression and experiences of physical and relational victimization...
April 16, 2018: Aggressive Behavior
https://www.readbyqxmd.com/read/29656881/fundamentals-of-functional-imaging-i-current-clinical-techniques
#3
A Luna, T Martín Noguerol, L Alcalá Mata
Imaging techniques can establish a structural, physiological, and molecular phenotype for cancer, which helps enable accurate diagnosis and personalized treatment. In recent years, various imaging techniques that make it possible to study the functional characteristics of tumors quantitatively and reproducibly have been introduced and have become established in routine clinical practice. Perfusion studies enable us to estimate the microcirculation as well as tumor angiogenesis and permeability using ultrafast dynamic acquisitions with ultrasound, computed tomography, or magnetic resonance (MR) imaging...
April 12, 2018: Radiología
https://www.readbyqxmd.com/read/29649467/monosodium-glutamate-ingestion-during-the-development-period-reduces-aggression-mediated-by-the-vagus-nerve-in-a-rat-model-of-attention-deficit-hyperactivity-disorder
#4
Ruriko Nishigaki, Yoshihiro Yokoyama, Yuko Shimizu, Ryosuke Marumoto, Sachiyo Misumi, Yoshitomo Ueda, Akimasa Ishida, Yasuyuki Shibuya, Hideki Hida
We used an umami substance, monosodium glutamate (MSG), as a simple stimulant to clarify the mechanism of the formation of emotional behavior. A 60 mM MSG solution was fed to spontaneously hypertensive rats (SHR), used as a model of attention-deficit hyperactivity disorder, from postnatal day 25 for 5 weeks kept in isolation. Emotional behaviors (anxiety and aggression) were then assessed by the open-field test, cylinder test and social interaction test. MSG ingestion during the developmental period resulted in a significant reduction in aggressive behavior but had few effects on anxiety-like behavior...
April 9, 2018: Brain Research
https://www.readbyqxmd.com/read/29625804/-use-of-the-2d-4d-digit-ratio-as-a-biological-marker-of-specific-language-disorders
#5
Antònia Font-Jordà, Antoni Gamundí, María Cristina Nicolau Llobera, Eva Aguilar-Mediavilla
INTRODUCTION: The finding of biological markers of specific language impairment would facilitate their detection and early intervention. In this sense, the 2D:4D finger ratio is considered an indirect indicator of prenatal exposure to testosterone. Previous studies have related it to linguistic competence and aggressive behaviour, and could be a candidate for a biological marker of language impairment. The aim was to compare the value of the 2D:4D ratio in children with Specific Language Impairment (SLI) with those of children with typical language development, as well as to establish to what extent this biological index correlates with the behaviour (linguistic, cognitive, social,...
April 3, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29625691/the-relation-between-working-conditions-aberrant-driving-behaviour-and-crash-propensity-among-taxi-drivers-in-china
#6
Yonggang Wang, Linchao Li, Carlo G Prato
Although the taxi industry is playing an important role in Chinese everyday life, little attention has been posed towards occupational health issues concerning the taxi drivers' working conditions, driving behaviour and road safety. A cross-sectional survey was administered to 1021 taxi drivers from 21 companies in four Chinese cities and collected information about (i) sociodemographic characteristics, (ii) working conditions, (iii) frequency of daily aberrant driving behaviour, and (iv) involvement in property-damage-only (PDO) and personal injury (PI) crashes over the past two years...
April 3, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29623624/the-economic-burden-of-small-cell-lung-cancer-a-systematic-review-of-the-literature
#7
REVIEW
Ashley Enstone, Maire Greaney, Manca Povsic, Robin Wyn, John R Penrod, Yong Yuan
BACKGROUND: Small cell lung cancer (SCLC), the most aggressive form of lung carcinoma, represents approximately 15% of all lung cancers; however, the economic and healthcare burden of SCLC is not well-defined. OBJECTIVE: The aim of this study was to explore the impact of SCLC on healthcare costs through a systematic literature review (SLR). METHODS: Using the OVID search engine, the SLR was conducted in PubMed, MEDLINE In-Process, EMBASE, EconLIT and the National Health Service Economic Evaluation Database (NHS EED)...
August 18, 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29611446/costs-and-disease-activity-in-early-rheumatoid-arthritis-in-1996-2000-and-2006-2011-improved-outcome-and-shift-in-distribution-of-costs-a-two-year-follow-up
#8
M Husberg, L Bernfort, E Hallert
OBJECTIVE: To evaluate changes in healthcare utilization, costs, and disease activity from 1996 to 2011 for patients with early rheumatoid arthritis (RA). METHOD: Two cohorts of patients with early RA, included in 1996-1998 (T1) and 2006-2009 (T2), were followed regularly. Healthcare utilization, costs, and disease activity were compared between cohorts during 2 years after diagnosis. RESULTS: Disease activity was significantly improved in T2 vs T1...
April 3, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29607012/threat-of-predation-alters-aggressive-interactions-among-spotted-salamander-ambystoma-maculatum-larvae
#9
Thomas J Hossie, Shawn MacFarlane, Amy Clement, Dennis L Murray
Intraspecific aggression represents a major source of mortality for many animals and is often experienced alongside the threat of predation. The presence of predators can strongly influence ecological systems both directly by consuming prey and indirectly by altering prey behavior or habitat use. As such, the threat of attack by higher level predators may strongly influence agonistic interactions among conspecifics via nonconsumptive (e.g., behaviorally mediated) predator effects. We sought to investigate these interactions experimentally using larval salamanders ( Ambystoma maculatum ) as prey and dragonfly nymphs ( Anax junius ) as predators...
March 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29606787/exposure-to-predators-reduces-collective-foraging-aggressiveness-and-eliminates-its-relationship-with-colony-personality-composition
#10
Colin M Wright, James L L Lichtenstein, Graham A Montgomery, Lauren P Luscuskie, Noa Pinter-Wollman, Jonathan N Pruitt
Predation is a ubiquitous threat that often plays a central role in determining community dynamics. Predators can impact prey species by directly consuming them, or indirectly causing prey to modify their behavior. Direct consumption has classically been the focus of research on predator-prey interactions, but substantial evidence now demonstrates that the indirect effects of predators on prey populations are at least as strong as, if not stronger than, direct consumption. Social animals, particularly those that live in confined colonies, rely on coordinated actions that may be vulnerable to the presence of a predator, thus impacting the society's productivity and survival...
August 2017: Behavioral Ecology and Sociobiology
https://www.readbyqxmd.com/read/29603205/neuroticism-and-marital-satisfaction-during-the-early-years-of-chinese-marriage-the-mediating-roles-of-marital-attribution-and-aggression
#11
Hongjian Cao, Xiaojiao Yuan, Mark Fine, Nan Zhou, Xiaoyi Fang
On the basis of three annual waves of data obtained from 268 Chinese couples, we tested an actor-partner interdependence mediation model in which spouses' neuroticism was linked to their own and partners' marital satisfaction through both intrapersonal processes (i.e., marital attribution) and interpersonal processes (i.e., marital aggression). Considering intra- and interpersonal processes simultaneously, four indirect, mediating pathways were identified: Time 1 Wives' Neuroticism → Time 2 Wives' Attribution or Aggression, while controlling for Time 1 Wives' Attribution or Aggression → Time 3 Wives' or Husbands' Marital Satisfaction, while controlling for Time 1 Wives' or Husbands' Marital Satisfaction...
March 30, 2018: Family Process
https://www.readbyqxmd.com/read/29574968/predictors-of-childhood-trajectories-of-overt-and-indirect-aggression-an-interdisciplinary-approach
#12
Carla Aimé, Daniel Paquette, Michèle Déry, Pierrette Verlaan
The aim of this study was to advance our understanding of the development of aggression in boys and girls by testing a model combining insights from both evolutionary theory and developmental psychology. A sample of 744 children (348 girls) between six and 13 years old was recruited in schools with high deprivation indices. Half of the sample (N = 372; 40.1% girls) had received special educational services for behavioral and/or socio-emotional problems. Two trajectories for overt aggression and two trajectories for indirect aggression were identified and binomial logistic regressions were used to identify environmental predictors and sex-specific patterns of these trajectories...
March 25, 2018: Aggressive Behavior
https://www.readbyqxmd.com/read/29552375/antisocial-traits-distress-tolerance-and-alcohol-problems-as-predictors-of-intimate-partner-violence-in-men-arrested-for-domestic-violence
#13
Meagan J Brem, Autumn Rae Florimbio, JoAnna Elmquist, Ryan C Shorey, Gregory L Stuart
Objective: Men with antisocial personality disorder (ASPD) traits are at an increased risk for consuming alcohol and perpetrating intimate partner violence (IPV). However, previous research has neglected malleable mechanisms potentially responsible for the link between ASPD traits, alcohol problems, and IPV perpetration. Efforts to improve the efficacy of batterer intervention programs (BIPs) would benefit from exploration of such malleable mechanisms. The present study is the first to examine distress tolerance as one such mechanism linking men's ASPD traits to their alcohol problems and IPV perpetration...
2018: Psychology of Violence
https://www.readbyqxmd.com/read/29552183/macrophages-in-skin-melanoma-the-key-element-in-melanomagenesis
#14
Malgorzata Pieniazek, Rafal Matkowski, Piotr Donizy
Cutaneous melanoma is an aggressive cancer and its onset and growth are associated, through direct and indirect interactions, with the cancer microenvironment. The microenvironment comprises a dynamic complex of numerous types of cells (due to histogenesis) that constantly interact with each other through multiple cytokines and signaling proteins. Macrophages are one of the most thoroughly studied pleiotropic cells of the immune system. One of their major cytophysiological functions is their involvement in phagocytosis...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29550329/the-biological-age-linked-to-oxidative-stress-modifies-breast-cancer-aggressiveness
#15
María Del Mar Sáez Freire, Adrián Blanco Gómez, Sonia Castillo Lluva, Aurora Gómez Vecino, Julie Milena Galvis Jiménez, Carmen Martín Seisdedos, María Isidoro García, Lourdes Hontecillas Prieto, María Begoña García-Cenador, Francisco Javier García Criado, María Carmen Patino Alonso, Purificación Galindo Villardón, Jian-Hua Mao, Carlos Prieto, Andrés Castellanos Martín, Lars Kaderali, Jesús Pérez Losada
The incidence of breast cancer increases with age until menopause, and breast cancer is more aggressive in younger women. The existence of epidemiological links between breast cancer and aging indicates that both processes share some common mechanisms of development. Oxidative stress is associated with both cancer susceptibility and aging. Here we observed that ERBB2-positive breast cancer, which developed in genetically heterogeneous ERBB2-positive transgenic mice generated by a backcross, is more aggressive in chronologically younger than in older mice (differentiated by the median survival of the cohort that was 79 weeks), similar to what occurs in humans...
March 14, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29537651/predicting-dating-behavior-from-aggression-and-self-perceived-social-status-in-adolescence
#16
Kirsty S Lee, Heather Brittain, Tracy Vaillancourt
We investigated the longitudinal associations between self-reported aggression, self-perceived social status, and dating in adolescence using an intrasexual competition theoretical framework. Participants consisted of 536 students in Grade 9 (age 15), recruited from a community sample, who were assessed on a yearly basis until they were in Grade 11 (age 17). Adolescents self-reported their use of direct and indirect aggression, social status, and number of dating partners. A cross-lagged panel model that controlled for within-time covariance and across-time stability while examining cross-lagged pathways was used to analyze the data...
March 14, 2018: Aggressive Behavior
https://www.readbyqxmd.com/read/29535615/longitudinal-links-between-executive-function-anger-and-aggression-in-middle-childhood
#17
Helena L Rohlf, Anna K Holl, Fabian Kirsch, Barbara Krahé, Birgit Elsner
Previous research has indicated that executive function (EF) is negatively associated with aggressive behavior in childhood. However, there is a lack of longitudinal studies that have examined the effect of deficits in EF on aggression over time and taken into account different forms and functions of aggression at the same time. Furthermore, only few studies have analyzed the role of underlying variables that may explain the association between EF and aggression. The present study examined the prospective paths between EF and different forms (physical and relational) and functions (reactive and proactive) of aggression...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29527107/stability-and-change-of-adolescents-aggressive-behavior-in-residential-youth-care
#18
E M A Eltink, J Ten Hoeve, T De Jongh, G H P Van der Helm, I B Wissink, G J J M Stams
Background: Aggression in residential youth care institutions is a frequent problem. Objective: The present short-term longitudinal study examined individual and institutional predictors of aggression in a group of 198 adolescents placed in open, semi-secure and secure residential institutions from the perspective of the importation and deprivation model. Methods: A total of 198 adolescents in residential youth care filled in questionnaires regarding group climate and aggression with a 3 month interval...
2018: Child & Youth Care Forum
https://www.readbyqxmd.com/read/29520890/protein-kinase-c-zeta-suppresses-low-or-high-grade-colorectal-cancer-crc-phenotypes-by-interphase-centrosome-anchoring
#19
Ravi Kiran Deevi, Arman Javadi, Jane McClements, Jekaterina Vohhodina, Kienan Savage, Maurice Bernard Loughrey, Emma Evergren, Frederick Charles Campbell
Histological grading provides prognostic stratification of colorectal cancer (CRC) by scoring heterogeneous phenotypes. Features of aggressiveness include aberrant mitotic spindle configurations, chromosomal breakage, and bizarre multicellular morphology, but pathobiology is poorly understood. Protein kinase C zeta (PKCz) controls mitotic spindle dynamics, chromosome segregation, and multicellular patterns, but its role in CRC phenotype evolution remains unclear. Here, we show that PKCz couples genome segregation to multicellular morphology through control of interphase centrosome anchoring...
March 9, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29511030/telatinib-is-an-effective-targeted-therapy-for-pseudomyogenic-hemangioendothelioma
#20
David Gerardus Pieter van IJzendoorn, Stefan Sleijfer, Hans Gelderblom, Ferry A L M Eskens, Geert Jlh van Leenders, Karoly Szuhai, Judith V M G Bovee
PURPOSE: Pseudomyogenic hemangioendothelioma (PHE) is an extremely rare locally aggressive neoplasm with endothelial differentiation, which often presents with multiple lesions. These tumors have characteristic SERPINE1-FOSB fusions. We report a 17 years old patient with advanced unresectable PHE with a durable complete remission to the multi-tyrosine kinase inhibitor telatinib. The aim of this study was to generate an in vitro model for PHE, to study the functional consequences of SERPINE1-FOSB in endothelial cells, and its interaction with telatinib, to biologically substantiate the complete response to telatinib...
March 6, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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