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Indirect Aggression

Matthew T Cook
Metastatic breast cancer is typically an extremely aggressive cancer with poor prognosis. Metastasis requires the orchestration of homeostatic factors and cellular programs, many of which are potential therapeutic targets. Luteolin (2-[3,4-dihydroxyphenyl]-5,7-dihydroxy-4-chromenone), is a naturally occurring flavonoid found in fruits and vegetables that exhibits many anticancer properties. Luteolin obstructs metastasis through both direct and indirect mechanisms. For instance, luteolin may suppress breast cancer invasion by acting as an antiangiogenic therapeutic inhibiting VEGF production and its receptor's activity...
2018: Breast Cancer: Targets and Therapy
Jeremy Pollack, Colin Holbrook, Daniel M T Fessler, Adam Maxwell Sparks, James G Zerbe
The perceived support of supernatural agents has been historically, ethnographically, and theoretically linked with confidence in engaging in violent intergroup conflict. However, scant experimental investigations of such links have been reported to date, and the extant evidence derives largely from indirect laboratory methods of limited ecological validity. Here, we experimentally tested the hypothesis that perceived supernatural aid would heighten inclinations toward coalitional aggression using a realistic simulated coalitional combat paradigm: competitive team paintball...
June 18, 2018: Human Nature: An Interdisciplinary Biosocial Perspective
Pedro Rosmaninho, Susanne Mükusch, Valerio Piscopo, Vera Teixeira, Alexandre Asf Raposo, Rolf Warta, Romina Bennewitz, Yeman Tang, Christel Herold-Mende, Stefano Stifani, Stefan Momma, Diogo S Castro
Glioblastoma is the most common and aggressive brain tumor, with a subpopulation of stem-like cells thought to mediate its recurring behavior and therapeutic resistance. The epithelial-mesenchymal transition (EMT) inducing factor Zeb1 was linked to tumor initiation, invasion, and resistance to therapy in glioblastoma, but how Zeb1 functions at molecular level and what genes it regulates remain poorly understood. Contrary to the common view that EMT factors act as transcriptional repressors, here we show that genome-wide binding of Zeb1 associates with both activation and repression of gene expression in glioblastoma stem-like cells...
June 14, 2018: EMBO Journal
María Del Mar Sáez-Freire, Adrián Blanco-Gómez, Sonia Castillo-Lluva, Aurora Gómez-Vecino, Julie Milena Galvis-Jiménez, Carmen Martín-Seisdedos, María Isidoro-García, Lourdes Hontecillas-Prieto, María Begoña García-Cenador, Francisco Javier García-Criado, María Carmen Patino-Alonso, Purificación Galindo-Villardón, Jian-Hua Mao, Carlos Prieto, Andrés Castellanos-Martín, Lars Kaderali, Jesús Pérez-Losada
The data presented in this article are related to the research paper entitled "The biological age linked to oxidative stress modifies breast cancer aggressiveness" (M.M. Sáez-Freire, A. Blanco-Gómez, S. Castillo-Lluva, A. Gómez-Vecino, J.M. Galvis-Jiménez, C. Martín-Seisdedos, M. Isidoro-García, L. Hontecillas-Prieto, M.B. García-Cenador, F.J. García-Criado, M.C. Patino-Alonso, P. Galindo-Villardón, J.H. Mao, C. Prieto, A. Castellanos-Martín, L. Kaderali, J. Pérez-Losada). The data shown were obtained from a population of transgenic mice, MMTV- Erbb2/Neu , with different susceptibility to breast cancer and a mixed genetic background generated by backcrossing...
June 2018: Data in Brief
Rayan Naser, Abdullah Aldehaiman, Escarlet Díaz-Galicia, Stefan T Arold
Focal adhesion kinase (FAK) and its close paralogue, proline-rich tyrosine kinase 2 (PYK2), are key regulators of aggressive spreading and metastasis of cancer cells. While targeted small-molecule inhibitors of FAK and PYK2 have been found to have promising antitumor activity, their clinical long-term efficacy may be undermined by the strong capacity of cancer cells to evade anti-kinase drugs. In healthy cells, the expression and/or function of FAK and PYK2 is tightly controlled via modulation of gene expression, competing alternatively spliced forms, non-coding RNAs, and proteins that directly or indirectly affect kinase activation or protein stability...
June 11, 2018: Cancers
Karen Brady, Nina Cracknell, Helen Zulch, Daniel Simon Mills
Background: Working dogs are selected based on predictions from tests that they will be able to perform specific tasks in often challenging environments. However, withdrawal from service in working dogs is still a big problem, bringing into question the reliability of the selection tests used to make these predictions. Methods: A systematic review was undertaken aimed at bringing together available information on the reliability and predictive validity of the assessment of behavioural characteristics used with working dogs to establish the quality of selection tests currently available for use to predict success in working dogs...
2018: Frontiers in Veterinary Science
Niekla Survia Andiesta, Maimunah A Hamid, Kkc Lee, Allan Pau
BACKGROUND: In 2012, nearly 4000 children in Malaysia were referred to hospital pediatric dental services due to dental caries. Recent research has reported the effectiveness of dental home visits in preventing caries development in young children. Dental home visits (DHVs) are described as an ongoing relationship between the dentist and their patients, providing all aspects of a preventive oral health care program in the presence of the parents at home. OBJECTIVE: The objective of this study is to evaluate the cost-effectiveness of dental home visits and oral health information, in the form of educational leaflets, in preventing new caries development in young children, compared to those receiving only educational leaflets over a period of two years...
June 6, 2018: JMIR Research Protocols
Todd E Shelly
Lek mating systems are relatively rare but occur in a diverse taxonomic array of animals, including birds, mammals, anurans, and insects. Such systems exhibit four features: 1) males provide no parental care and supply only gametes; 2) males are spatially aggregated at mating arenas (or leks); 3) males do not control access to resources critical to females; and 4) females are free to select mates at the arena. Among insects, fruit flies of the families Tephritidae and Drosophilidae display lek behavior that closely resembles the 'classic' lek mating systems of vertebrate species...
May 1, 2018: Journal of Insect Science
Sanjoy Samanta, Santosh Guru, Ameer L Elaimy, John J Amante, Jianhong Ou, Jun Yu, Lihua J Zhu, Arthur M Mercurio
Insulin-like growth factor-2 mRNA-binding protein 3 (IMP3) is an oncofetal protein associated with many aggressive cancers and implicated in the function of breast cancer stem cells (CSCs). The mechanisms involved, however, are poorly understood. We observed that IMP3 facilitates the activation of TAZ, a transcriptional co-activator of Hippo signaling that is necessary for the function of breast CSCs. The mechanism by which IMP3 activates TAZ involves both mRNA stability and transcriptional regulation. IMP3 stabilizes the mRNA of an alternative WNT ligand (WNT5B) indirectly by repressing miR145-5p, which targets WNT5B, resulting in TAZ activation by alternative WNT signaling...
May 29, 2018: Cell Reports
Francine Nesello Melanda, Hellen Geremias Dos Santos, Denise Albieri Jodas Salvagioni, Arthur Eumann Mesas, Alberto Durán González, Selma Maffei de Andrade
This study aimed to identify associations between sociodemographic, workplace, and school environmental factors and the occurrence of physical violence against teachers at school. This was a cross-sectional study of teachers that had been working for at least a year in elementary or middle schools in the state school system in Londrina, Paraná State, Brazil. A convenience sample was taken of the 20 schools with the most teachers in the city of Londrina. Data were obtained through interviews and self-completed questionnaires in 2012 and 2013...
2018: Cadernos de Saúde Pública
T Volden, J Goldowsky, N Schmid, V Revol
Precise metering in liquid dispensing applications often requires application-specific solutions due to incompatibilities of the sensor and actuator components with the dispensed liquids. Some reoccurring challenges are aggressive liquids that would damage the sensors or tubing, the need for sterile liquids while the pumps or sensors cannot be sterilized, or media that can clog the sensor channels. Two different dispensing systems are here presented where the dispensing flow rate or volume is indirectly measured through a coupled pressure change or airflow, thus avoiding contact between the sensor and liquid...
May 1, 2018: SLAS Technology
Gentiana Sadikaj, D S Moskowitz
BACKGROUND: Alcohol intoxication facilitates interpersonal aggression, but this effect depends on person and situation characteristics. Using the Alcohol Myopia Model, we examined the joint influence of alcohol, trait anger, and state anger on the association between perceived quarrelsomeness in an interaction partner and quarrelsome behavior in naturally occurring interpersonal interactions. METHODS: Using an event-contingent recording method over a 20-day period, community adults reported their perception of an interaction partner's quarrelsome behavior, their own anger and quarrelsome behavior, and the number of alcohol drinks consumed up to 3 hours prior to an interpersonal interaction...
May 25, 2018: Alcoholism, Clinical and Experimental Research
Christopher S Walker, Kara K Walker, Gabo Paulo, Anne E Pusey
Chimpanzees (Pan troglodytes) are primarily frugivorous but consume a variable amount of meat from a variety of organisms, including other chimpanzees. Cannibalism is rare, usually follows lethal aggression, and does not occur following natural deaths. While chimpanzee cannibalism has been documented at multiple sites, many instances of this behavior go unrecorded. Identification of chimpanzee remains in feces, however, can provide indirect evidence of cannibalism. Hair, in particular, typically passes through the gastrointestinal tract undamaged and is commonly used for purposes of identification in wildlife forensics...
May 22, 2018: Folia Primatologica; International Journal of Primatology
Anamaria Balić, Zrinka Bukvić Mokos, Branka Marinović, Daniela Ledić Drvar
Dear Editor, Pitted keratolysis (PK), also known as keratosis plantaris sulcatum, is a non-inflammatory, bacterial, superficial cutaneous infection, characterized by many discrete superficial crateriform ''pits'' and erosions in the thickly keratinized skin of the weight-bearing regions of the soles of the feet (1). The disease often goes unnoticed by the patient, but when it is noticed it is because of the unbearable malodor and hyperhidrosis of the feet, which are socially unacceptable and cause great anxiety to many of the patients...
April 2018: Acta Dermatovenerologica Croatica: ADC
Thomas F Denson, Siobhan M O'Dean, Khandis R Blake, Joanne R Beames
We review the literature on aggression in women with an emphasis on laboratory experimentation and hormonal and brain mechanisms. Women tend to engage in more indirect forms of aggression (e.g., spreading rumors) than other types of aggression. In laboratory studies, women are less aggressive than men, but provocation attenuates this difference. In the real world, women are just as likely to aggress against their romantic partner as men are, but men cause more serious physical and psychological harm. A very small minority of women are also sexually violent...
2018: Frontiers in Behavioral Neuroscience
Taban Salem, E Samuel Winer, D Gage Jordan, Michael R Nadorff, Jennifer R Fanning, Jessica Bryant, Mitchell E Berman, Jennifer C Veilleux
Depression has been linked to multiple forms of aggressive behavior in college students; however, it is unclear which aspects of depression explain this connection. Anhedonia, defined as the loss of interest and/or pleasure in previously enjoyed activities, may provide unique information about relationships between depression and aggression. Using cross-sectional data from two independent samples of college students ( N = 747 and N = 736 for Study 1 and Study 2, respectively), we examined whether anhedonia helped explain the relationship between broader depressive symptoms and different forms of aggressive and antisocial behavior...
May 1, 2018: Journal of Interpersonal Violence
Thomas Claßen, Maxie Bunz
Natural spaces and especially urban green and blue spaces have been recognised for a long time as spaces with great potential for protecting and promoting human health and well-being. They may affect human physical, mental and social health and well-being in various ways. On one hand, this comes to pass through reduction and moderation of potential environmental health risks (e. g. noise, particulate matter, heat), psycho-physiological effects of nature experience, as well as physical effects of exposure to natural compounds and elements...
May 16, 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Yizhe Huang, Daniel Jian Sun, Li-Hui Zhang
Inappropriate cruising speed, such as speeding, is one of the major contributors to the road safety, which increases both the quantitative number and severity of traffic accidents. Previous studies have indicated that traffic congestion is one of the primary causes of drivers' frustration and aggression, which may lead to inappropriate speed choice. In this study, the large taxi floating car data (FCD) was used to empirically evaluate how traffic congestion-related negative moods, defined as state aggressiveness, affected drivers' speed choice...
May 9, 2018: Accident; Analysis and Prevention
Jill E P Knapen, Nancy M Blaker, Mark Van Vugt
Inspired by an evolutionary psychological perspective on the Napoleon complex, we hypothesized that shorter males are more likely to show indirect aggression in resource competitions with taller males. Three studies provide support for our interpretation of the Napoleon complex. Our pilot study shows that men (but not women) keep more resources for themselves when they feel small. When paired with a taller male opponent (Study 1), shorter men keep more resources to themselves in a game in which they have all the power (dictator game) versus a game in which the opponent also has some power (ultimatum game)...
May 1, 2018: Psychological Science
Pan Liu, Yanxia Jin, Haseeb Sattar, Hailing Liu, Weiling Xie, Fuling Zhou
Multiple myeloma (MM) is a complex aggressive mature B-cell malignancy. Although with the wide application of chemotherapy drugs, it remains incurable and the vast majority of patients relapse. Natural killer (NK) cells, also known as CD56+ CD3- large granular lymphocytes, are cytotoxic innate immune cells against MM without prior sensitization steps. NK cell-based immunotherapy is extensively promising in a wide range of clinical settings. It is worthy of note that some novel drugs such as monoclonal antibodies (mAbs), proteasome inhibitors (PIs), and immunomodulators (IMiDs) directly or indirectly activate NK cells to enhance their antitumor activity, and the combined regimens significantly improve the prognosis of MM patients...
May 2018: Journal of Leukocyte Biology
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