S Y Ebstein, A Rafique, Y Zhou, A Krasco, W Montalvo-Ortiz, L Yu, L Custodio, R C Adam, N Bloch, K Lee, F Adewale, D Vergata, A Luz, S Coquery, B Daniel, E Ullman, M C Franklin, A Hermann, T Huang, W Olson, S Davis, A J Murphy, M A Sleeman, J Wei, D Skokos
V-set and immunoglobulin domain-containing 4 (VSIG4) is a complement receptor of the immunoglobulin superfamily that is specifically expressed on tissue resident macrophages, and its many reported functions and binding partners suggest a complex role in immune function. VSIG4 is reported to have a role in immune surveillance as well as in modulating diverse disease phenotypes such as infections, autoimmune conditions, and cancer. However, the mechanism(s) governing VSIG4's complex, context-dependent role in immune regulation remain elusive...
June 21, 2023: Glycobiology