Qilin Chen, Huimin Jiang, Rong Ding, Jinjie Zhong, Longfei Li, Junli Wan, Xiaoqian Feng, Liping Peng, Xia Yang, Han Chen, Anshuo Wang, Jia Jiao, Qin Yang, Xuelan Chen, Xiaoqin Li, Lin Shi, Gaofu Zhang, Mo Wang, Haiping Yang, Qiu Li
Nephrotic syndrome (NS) is a relatively rare and serious presentation of IgA nephropathy (IgAN) (NS-IgAN). Previous research has suggested that the pathogenesis of NS-IgAN may involve circulating immune imbalance and kidney injury; however, this has yet to be fully elucidated. To investigate the cellular and molecular status of NS-IgAN, we performed single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) and kidney cells from pediatric patients diagnosed with NS-IgAN by renal biopsy...
2023: Frontiers in Immunology