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Cytopathology

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https://www.readbyqxmd.com/read/28225151/cytopathologic-differential-diagnosis-of-low-grade-urothelial-carcinoma-and-reactive-urothelial-proliferation-in-bladder-washings-a-logistic-regression-analysis
#1
Ebru Cakir, Ulku Kucuk, Emel Ebru Pala, Ozlem Sezer, Rahmi Gokhan Ekin, Ozgur Cakmak
Conventional cytomorphologic assessment is the first step to establish an accurate diagnosis in urinary cytology. In cytologic preparations, the separation of low-grade urothelial carcinoma (LGUC) from reactive urothelial proliferation (RUP) can be exceedingly difficult. The bladder washing cytologies of 32 LGUC and 29 RUP were reviewed. The cytologic slides were examined for the presence or absence of the 28 cytologic features. The cytologic criteria showing statistical significance in LGUC were increased numbers of monotonous single (non-umbrella) cells, three-dimensional cellular papillary clusters without fibrovascular cores, irregular bordered clusters, atypical single cells, irregular nuclear overlap, cytoplasmic homogeneity, increased N/C ratio, pleomorphism, nuclear border irregularity, nuclear eccentricity, elongated nuclei, and hyperchromasia (p ˂ 0...
February 22, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28217980/reproducibility-of-atypia-of-undetermined-significance-follicular-lesion-of-undetermined-significance-category-using-the-bethesda-system-for-reporting-thyroid-cytology-when-reviewing-slides-from-different-institutions-a-study-of-interobserver-variability-among
#2
Vijayalakshmi Padmanabhan, Carrie B Marshall, Guliz Akdas Barkan, Mohiedean Ghofrani, Alice Laser, Idris Tolgay Ocal, Charles David Sturgis, Rhona Souers, Daniel F I Kurtycz
BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) offers a six-tiered diagnostic scheme for thyroid Fine Needle Aspiration (FNA): Benign, Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance (AUS/FLUS), suspicious for follicular neoplasm, suspicious for malignancy, malignant, and unsatisfactory with an aim to standardize diagnostic criteria. Reported rate of AUS/FLUS category in the literature has varied from 3% to 20.5%. METHODS: The aim of this study was to assess interobserver variability among cytopathologists to assess reproducibility of the AUS/FLUS category...
February 20, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28207201/diagnostic-yield-of-cytopathology-in-evaluating-pericardial-effusions-clinicopathologic-analysis-of-419-specimens
#3
Jad Saab, Rana S Hoda, Navneet Narula, Syed A Hoda, Brian E Geraghty, Abu Nasar, Susan A Alperstein, Jeffrey L Port, Tamar Giorgadze
BACKGROUND: Pericardial effusions can cause considerable morbidity and potentially may lead to mortality. Malignant pericardial effusions are uncommon, and data on malignancies encountered in pericardial effusion cytology specimens are limited. METHODS: Relevant records of all pericardial effusions from January 2008 to September 2014 were examined and compared with pericardial biopsy results when performed. Discrepant cases were reviewed to determine the cause of the disagreement...
February 2017: Cancer
https://www.readbyqxmd.com/read/28206852/british-journal-of-biomedical-science-in-2016-what-have-we-learned
#4
Andrew Blann
In 2016, the British Journal of Biomedical Science published 36 reports outlining specific advances in each of the various disciplines within biomedical science. These were one review, 25 original articles, 9 'In Brief' reports and one letter to the Editor. Of these, the majority were in blood science (5 in biochemistry, 7 in haematology and 2 in immunology) and infection science (8 in microbiology, 2 in virology) with a smaller number in cellular sciences (6 in cellular pathology and 2 in cytopathology). Three reports considered both biochemistry and immunology, while another reported an advance in the identification of chromosomal abnormalities...
January 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28205345/differential-diagnosis-of-well-differentiated-squamous-cell-carcinoma-from-non-neoplastic-oral-mucosal-lesions-new-cytopathologic-evaluation-method-dependent-on-keratinization-related-parameters-but-not-nuclear-atypism
#5
Hitoshi Hara, Tsuneo Misawa, Eri Ishii, Miki Nakagawa, Saki Koshiishi, Kenji Amemiya, Toshio Oyama, Kazuya Tominaga, Jun Cheng, Akio Tanaka, Takashi Saku
BACKGROUND: The cytology of oral squamous cell carcinoma (SCC) is challenging because oral SCC cells tend to be well differentiated and lack nuclear atypia, often resulting in a false negative diagnosis. The purpose of this study was to establish practical cytological parameters specific to oral SCCs. METHODS: We reviewed 123 cases of malignancy and 53 of non-neoplastic lesions of the oral mucosa, which had been diagnosed using both cytology and histopathology specimens...
February 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28198123/inside-this-month-s-cytopathology
#6
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28198122/cytopathology-moves-on-with-a-growing-team
#7
EDITORIAL
M Sheaff
No abstract text is available yet for this article.
February 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28198053/morphology-quiz-cytopathology-of-a-thyroid-neoplasm
#8
M Nicola, M Onorati, S Bellone, P Collini, F Di Nuovo
No abstract text is available yet for this article.
February 14, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28196844/cervical-cancer-incidence-after-normal-cytological-sample-in-routine-screening-using-surepath-thinprep-and-conventional-cytology-population-based-study
#9
Kirsten Rozemeijer, Steffie K Naber, Corine Penning, Lucy I H Overbeek, Caspar W N Looman, Inge M C M de Kok, Suzette M Matthijsse, Matejka Rebolj, Folkert J van Kemenade, Marjolein van Ballegooijen
Objective To compare the cumulative incidence of cervical cancer diagnosed within 72 months after a normal screening sample between conventional cytology and liquid based cytology tests SurePath and ThinPrep.Design Retrospective population based cohort study.Setting Nationwide network and registry of histo- and cytopathology in the Netherlands (PALGA), January 2000 to March 2013.Population Women with 5 924 474 normal screening samples (23 833 123 person years).Exposure Use of SurePath or ThinPrep versus conventional cytology as screening test...
February 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28195650/cell-tube-block-a-new-technique-to-produce-cell-blocks-from-fluid-cytology-samples
#10
Ricardo Marcos, Marta Santos, Carla Marrinhas, Mario Caniatti
BACKGROUND: Cell blocks are widely used in human cytopathology. Several techniques have been proposed to convert fluid specimens into solid material, which after embedding in paraffin can be used for histochemistry, immunohistochemistry, or molecular testing. In contrast, only in the last few years, have cell blocks begun to be used in the veterinary field. OBJECTIVES: The purpose of the study was to present the production and features of cell tube blocks (CTB) with veterinary liquid samples...
February 13, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28192645/cytological-molecular-and-clinical-features-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-versus-invasive-forms-of-follicular-variant-of-papillary-thyroid-carcinoma
#11
Liena Zhao, Dora Dias-Santagata, Peter M Sadow, William C Faquin
BACKGROUND: The noninvasive follicular variant of papillary thyroid carcinoma (PTC) has an indolent clinical behavior in comparison with other PTCs, including the invasive follicular variant of papillary thyroid carcinoma (IFVPTC). Recently, the term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was introduced to emphasize the low biological potential of these tumors. This study compares clinical, cytological, and molecular features of NIFTP and IFVPTC...
February 13, 2017: Cancer
https://www.readbyqxmd.com/read/28192631/thyroid-cytology-nuclear-versus-architectural-atypia-within-the-atypia-of-undetermined-significance-follicular-lesion-of-undetermined-significance-bethesda-category-have-significantly-different-rates-of-malignancy
#12
Tiffany Rui Xuan Gan, Min En Nga, Jeffrey Huey Yew Lum, Wendy Meihua Wong, Wee Boon Tan, Rajeev Parameswaran, Kee Yuan Ngiam
BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology is the most widely used classification system for the reporting of thyroid fine-needle aspiration cytology (FNAC) specimens. However, the "atypical" category ("atypia of undetermined significance" [AUS] or "follicular lesion of undetermined significance" [FLUS]) continues to cause diagnostic and therapeutic dilemmas. The objectives of this study were to describe the differential malignancy rates of FNACs diagnosed as AUS/FLUS based on nuclear or architectural atypia and to assess the significance of demographic and ultrasonographic features in predicting malignancy in this category...
February 13, 2017: Cancer
https://www.readbyqxmd.com/read/28185442/the-role-of-ancillary-tests-in-the-evaluation-and-management-of-patients-with-negative-and-non-diagnostic-pancreatic-cyst-aspirates
#13
Suzanne M Selvaggi
BACKGROUND: Fine needle aspiration of pancreatic cystic lesions has its limitations as the cytology is often paucicellular to acellular. This study reports on the value of ancillary tests, amylase and carcinoembryonic, in the evaluation and management of patients with negative and non-diagnostic pancreatic cysts. METHODS: From January 1, 2010 through December 31, 2015, the Cytopathology Laboratory processed 119 pancreatic cyst aspirates of which 51(43%) were negative and 52(44%) were non-diagnostic and form the basis of this study...
February 10, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28185423/granulocyte-colony-stimulating-factor-producing-pancreatic-anaplastic-carcinoma-in-ascitic-fluid-at-initial-diagnosis-a-case-report
#14
Nao Kubota, Yoshiki Naito, Akihiko Kawahara, Tomoki Taira, Tomohiko Yamaguchi, Tomoko Yoshida, Hideyuki Abe, Yorihiko Takase, Chihiro Fukumitsu, Kazuya Murata, Yusuke Ishida, Yoshinobu Okabe, Yoshizo Kimura, Masahiko Tanigawa, Yutaro Mihara, Masamichi Nakayama, Rin Yamaguchi, Jun Akiba, Hirohisa Yano
Granulocyte colony-stimulating factor (G-CSF)-producing pancreatic tumors are extremely rare. These tumors have an aggressive clinical course and no established treatment. Here, we report an autopsy case of G-CSF-production in pancreatic anaplastic carcinoma (PAC). A 72-year-old woman presented with a large pancreatic head mass and multiple liver metastases. Laboratory data showed leukocytosis (leukocyte count 113.3 × 10(3) /µL) and high serum G-CSF levels (441 pg/mL; normal range: <39.0 pg/mL). The ascitic fluid was submitted to our pathology laboratory at initial diagnosis...
February 10, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28182081/cytopathologic-features-of-an-unusual-case-of-multiple-eccrine-spiradenomas-misdiagnosed-as-a-malignant-round-cell-tumor
#15
Bharat Rekhi, Archi Agarwal
A 28-year-old lady presented with multiple swellings in her left shoulder, associated with intermittent pain since last one and a half years. Radiologic imaging revealed multiple, well-defined, subcutaneous lesions in her left supraclavicular region. Fine needle aspiration cytology (FNAC) smears were initially reported as Ewing sarcoma, elsewhere. On review, the smears showed cohesive clusters of round-to-oval cells with scant cytoplasm, which were focally arranged in an acinar-rosetting pattern around hyaline "droplets/bodies," along with few scattered lymphocytes against a background of red blood cells...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28182080/cytopathology-practice-in-kumasi-a-2-year-retrospective-audit
#16
Babatunde M Duduyemi, Osei Owusu-Afriyie, Kwabena O Danquah, Derick Na Osakunor
AIM: Surgical pathology service is generally unavailable in most developing countries and comes with challenges. Cytopathology is a reliable, inexpensive adjunct to surgical histopathology. We present a retrospective review of the various cytopathology cases received at the department. MATERIALS AND METHODS: A retrospective review of 836 cytopathology cases from January 2010 to December 2011 at the Department of Pathology of our hospital was conducted. All cytopathology reports and records from the department were retrieved and analyzed using the Statistical Package for the Social Sciences version 16 for windows...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28166519/the-bethesda-system-for-reporting-thyroid-cytopathology-a-meta-analysis
#17
Maher A Sughayer, Niveen Abdullah
No abstract text is available yet for this article.
February 7, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28160441/unusual-findings-in-thyroid-cytology-and-histology
#18
Alireza Najafian, Stacie Kahan, Martha A Zeiger, Matthew T Olson
INTRODUCTION: Although cytology and histopathology of thyroid lesions generally fall into common, well-defined categories, there are uncommon cases with unusual fine needle aspiration (FNA) findings or histology. Herein, we review the prevalence and characteristics of rare thyroid cytology and histopathology findings at a tertiary hospital. METHODS: Institutional data from >31,000 patients with a thyroid pathology from 1995 to 2013 were queried. Both cytology and histology were available in 6,693 patients...
March 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28156542/the-level-of-soluble-programmed-death-ligand-1-in-lung-cancer-an-exploratory-biomarker-study
#19
Li Pan, Sutang Guo, Jiexian Jing, Xu Dong Zhang, Xia Song
: 249 Background: A new approach to immunotherapy based on programmed death 1 (PD-1) and programmed death ligand-1 (PD-L1) pathway represents a remarkable innovation in lung cancer treatment. There is growing evidence that lung cancer cells exploit the PD-L1 to cause local immune-suppression. The aim of this prospective study was to investigate the prevalence and prognostic roles of soluble PD-L1 (sPD-L1) protein in the blood of patients with lung cancer. METHODS: A total of 159 patients with lung cancer who were diagnosed by histopathology or cytopathology between July 2013 and October 2015 were enrolled...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152275/qualifiers-of-atypia-in-the-cytologic-diagnosis-of-thyroid-nodules-are-associated-with-different-afirma-gene-expression-classifier-results-and-clinical-outcomes
#20
Sylvan C Baca, Kristine S Wong, Kyle C Strickland, Howard T Heller, Matthew I Kim, Justine A Barletta, Edmund S Cibas, Jeffrey F Krane, Ellen Marqusee, Trevor E Angell
BACKGROUND: Thyroid nodules with atypia of undetermined significance (AUS) on fine-needle aspiration (FNA) have a low risk of malignancy that appears to vary based on specific features described in the AUS diagnosis. The Afirma gene expression classifier (GEC) is a molecular test designed to improve preoperative risk stratification of thyroid nodules, but its performance for different patterns of AUS has not been defined. The objective of this study was to assess GEC results and clinical outcomes in AUS nodules with architectural atypia (AUS-A), cytologic atypia (AUS-C) or both (AUS-C/A)...
February 2, 2017: Cancer
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