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Cytopathology

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https://www.readbyqxmd.com/read/29768518/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-ebus-tbna-in-diagnosis-of-mediastinal-lesions
#1
Ricardo Sales Dos Santos, Marcia Jacomelli, Juliana Pereira Franceschini, Iunis Suzuki, Altair da Silva Costa, Christina Shiang, Addy Lidvina Mejia Palomino
OBJECTIVE: To describe the results of endobronchial ultrasound-guided transbronchial needle aspiration in making diagnosis of mediastinal injuries associated to different causes. METHODS: A retrospective cross-sectional study of patients submitted to Endobronchial ultrasound-guided transbronchial needle aspiration at a private organization, between June 2013 and October 2016. All cases referred for collection of lymph nodes or peritracheal/peribronchial masses by endobronchial ultrasound-guided transbronchial needle aspiration, and evaluated through tomography or PET-CT were included...
May 14, 2018: Einstein
https://www.readbyqxmd.com/read/29765019/relationship-between-circulating-vascular-endothelial-growth-factor-and-its-soluble-receptor-in-patients-with-hemorrhagic-fever-with-renal-syndrome
#2
Emil Pal, Misa Korva, Katarina Resman Rus, Nataša Kejžar, Petra Bogovič, Franc Strle, Tatjana Avšič-Županc
Hemorrhagic fever with renal syndrome (HFRS) is characterized by endothelial dysfunction with capillary leakage without obvious cytopathology in the capillary endothelium. The aim of the study was to analyze the kinetics of vascular endothelial growth factor (VEGF) and its soluble receptor (sVEGFR-2) in HFRS patients infected with Dobrava (DOBV) or Puumala virus (PUUV). VEGF and sVEGFR-2 levels were measured in daily plasma and urine samples of 73 patients with HFRS (58 with PUUV, 15 with DOBV) and evaluated in relation to clinical and laboratory variables...
May 16, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29742978/needle-biopsy-of-routine-thyroid-nodules-should-be-performed-using-a-capillary-action-technique-with-24-27-gauge-needles-a-systematic-review-and-meta-analysis
#3
William Moss, Andrey Finegersh, John Pang, Joseph A Califano, Charles S Coffey, Ryan Orosco, Kevin T Brumund
BACKGROUND: Fine needle biopsy is the international standard for diagnostic evaluation of thyroid nodules. There is a lack of consensus regarding the optimal fine needle biopsy technique. The implementation of capillary action versus aspiration and the optimal needle gauge remain topics of debate. METHODS: A systematic review of the Medline, Embase and Cochrane databases was performed in accordance with PRISMA guidelines. Articles evaluating the effects of capillary action vs...
May 10, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29732003/single-cell-genetic-analysis-validates-cytopathological-identification-of-circulating-cancer-cells-in-patients-with-clear-cell-renal-cell-carcinoma
#4
Lucile Broncy, Basma Ben Njima, Arnaud Méjean, Christophe Béroud, Khaled Ben Romdhane, Marius Ilie, Veronique Hofman, Jane Muret, Paul Hofman, Habiba Chaabouni Bouhamed, And Patrizia Paterlini-Bréchot
Context: Circulating Rare Cells (CRC) are non-haematological cells circulating in blood. They include Circulating Cancer Cells (CCC) and cells with uncertain malignant features (CRC-UMF) according to cytomorphology. Clear cell renal cell carcinomas frequently bear a mutated Von Hippel-Lindau (VHL) gene. Aim: To match blind genetic analysis of CRC and tumor samples with CRC cytopathological diagnosis. Results: 29/30 patients harboured CRC (20 harboured CCC, 29 CRC-UMF) and 25/29 patients carried VHL mutations in their tumour...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29729723/comparison-of-the-sensitivity-of-three-methods-for-the-early-diagnosis-of-sporotrichosis-in-cats
#5
J N Silva, L H M Miranda, R C Menezes, I D F Gremião, R V C Oliveira, S M M Vieira, F Conceição-Silva, L Ferreiro, S A Pereira
Sporotrichosis is caused by species of fungi within the Sporothrix schenckii complex that infect man and animals. In Rio de Janeiro, Brazil, an epidemic has been observed since 1998, with most of the cases being related to transmission from infected cats. Although the definitive diagnosis of feline sporotrichosis is made by fungal culture, cytopathological and histopathological examinations are used routinely, because the long culture period may delay treatment onset. However, alternative methods are desirable in cases of low fungal burden...
April 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29727061/international-telecytology-current-applications-and-future-potential
#6
Justin E Caron, Yong Ying, Qin Ye, Lirong Cheng, Jian Yu Rao
International telecytology can improve patient care by increasing access to regional and international expertise in cytopathology. The majority of international telecytology studies published to date have been based on static telepathology platforms. Overall concordance rates for these studies ranged from 71% to 93%. This is comparable to the concordance rates published for other studies comparing diagnoses made by digital still images to reference glass slides, which vary from 80% to 95%. Static telepathology systems are relatively cheap and easy to use, and have the potential to increase access to international experts in developing countries with limited resources...
May 4, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29723435/impact-on-clinical-follow-up-of-the-milan-system-for-salivary-gland-cytology-a-comparison-with-a-traditional-diagnostic-classification
#7
Lester J Layfield, Zubair Baloch, Sharon L Hirschowitz, Esther D Rossi
OBJECTIVE: No universally accepted classification exists for salivary gland fine-needle aspiration (FNA). The proposed Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) offers a uniform classification with management recommendations. We compared FNA diagnoses from a prior study with specific diagnoses with corresponding MSRSGC diagnoses. METHODS: One-hundred and sixty-four cases from a prior cytologic study with histologic follow-up were re-reviewed by one of the authors and assigned to one of the MSRSGC categories...
May 3, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29723428/dulcie-coleman-a-pioneer-of-cytology-in-the-uk-and-europe
#8
EDITORIAL
Amanda Herbert
We sadly announce the death earlier this year of Professor Dulcie V Coleman, the driving force behind the publication of Cytopathology in 1990 and pioneer of cytology in the UK and throughout Europe (Figure 1). She died peacefully in Naples, Florida on Sunday 4th February 2018 surrounded by her family including her husband of 60 years (Jack Poznansky), their four children and two of their 13 grandchildren several of whom contributed to her academic work and publications. She had moved to Florida to be nearer much of her family but returned regularly to continue her work at Imperial College...
May 3, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29721361/constant-quest-for-quality-digital-cytopathology
#9
Simone L Van Es, Janelle Greaves, Stephanie Gay, Jennifer Ross, Derek Holzhauser, Tony Badrick
Background: Special consideration should be given when creating and selecting cytopathology specimens for digitization to maximize quality. Advances in scanning and viewing technology can also improve whole-slide imaging (WSI) output quality. Methods: Accumulated laboratory experience with digitization of glass cytopathology slides was collected. Results: This paper describes characteristics of a cytopathology glass slide that can reduce quality on resulting WSI...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29719135/clinical-trial-cytology-use-of-on-site-evaluation-of-small-biopsy-and-fna-samples-for-clinical-trials-and-biomarker-research-studies
#10
Julia L Manzo, Jackie Cuda, Liron Pantanowitz, Juan Xing, Jing Yu, H Scott Beasley, Rajiv Dhir, Sara E Monaco
BACKGROUND: After increased requests for biopsies for clinical trials and biomarker research, the University of Pittsburgh Medical Center created a clinical trial research service that partnered pathology, radiology, and medicine to facilitate rapid on-site evaluation (ROSE) of fine-needle aspiration (FNA) and/or core needle biopsy (CNB) samples to confirm the presence of tumor in these studies. METHODS: Clinical trial coordinators organized biopsies for patients needing tumor samples for trials, and informed the cytopathology and radiology team...
May 2, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29715129/second-opinion-reviews-for-cancer-diagnoses-in-anatomic-pathology-a-comprehensive-cancer-center-s-experience
#11
Carolina Strosberg, Julie Gibbs, Diana Braswell, Ronni R Leslie, Jane Messina, Barbara A Centeno, Domenico Coppola
AIM: The objective of this study was to define the rates of discrepancy between outside pathological diagnoses and secondary reviews. MATERIALS AND METHODS: We assessed the rates of discordance between outside diagnoses and secondary reviews, categorizing by organ site and minor or major (affecting patient care) discordances. RESULTS: A total of 9,289 consecutive surgical pathology (SP) and cytopathology (CP) cases reviewed in 2015 were identified...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29704233/the-mutational-analysis-in-the-diagnostic-work-up-of-thyroid-nodules-the-real-impact-in-a-center-with-large-experience-in-thyroid-cytopathology
#12
E Macerola, T Rago, A Proietti, F Basolo, P Vitti
PURPOSE: Fine-needle aspiration (FNA) cytology is a mainstay in the evaluation of thyroid nodules, but fails to reach reliable results in 25-30% of cases. The role of molecular markers in helping clinical decisions has been investigated for the last years, but their clinical usefulness is still unsettled. METHODS: Mutation analysis of BRAF, RAS genes and TERT promoter was performed in a series of 617 consecutive cytological specimens undergoing FNA. RESULTS: The 617 nodules had the following cytological diagnosis: non diagnostic 22 (3...
April 27, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29696036/malignancy-rates-in-thyroid-nodules-classified-as-bethesda-categories-iii-and-iv-retrospective-data-from-a-tertiary-center
#13
Beatriz Godoi Cavalheiro, Ana Kober Nogueira Leite, Leandro Luongo de Matos, Aline Palermo Miazaki, Jan Marcel Ientile, Marco Aurelio V Kulcsar, Claudio Roberto Cernea
Background: Thyroid fine needle aspiration (FNA) has a well-established role in the diagnosis of thyroid nodules, and the "Bethesda system for reporting thyroid cytopathology" is used to interpret FNA results. Bethesda categories III and IV encompass varying risks of malignancy. In addition, there is some debate in the literature about how to select among many acceptable treatment approaches. Objectives: To establish an association between these 2 cytological categories and malignancy rates in patients treated in a referral tertiary cancer center, where surgical treatment is recommended for all these patients...
January 2018: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29695287/the-importance-of-endoscopic-ultrasound-fine-needle-aspiration-in-the-diagnosis-of-solid-pseudopapillary-tumor-of-the-pancreas-two-case-reports
#14
Diogo Turiani Hourneaux De Moura, Martin Coronel, Igor Braga Ribeiro, Galileu Ferreira Ayala Farias, Maria Auxiliadora Choez, Rodrigo Rocha, Marcello Pecoraro Toscano, Eduardo Guimarães Hourneaux De Moura
BACKGROUND: Solid pseudopapillary tumor of the pancreas, otherwise known as solid and cystic tumor or Frantz tumor, is an unusual form of pancreatic carcinoma, with unknown etiopathogenesis, that accounts for 0.2 to 2.7% of all pancreatic tumors. It is defined as an exocrine pancreatic neoplasia that mainly affects women between the second and third decade of life, and its management is not well defined. Endoscopic ultrasound offers a key anatomical advantage in accessing the pancreas and endoscopic ultrasound fine-needle aspiration has become the gold standard method for the diagnosis of pancreatic lesions...
April 26, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29683536/a-retrospective-three-year-study-of-salivary-gland-fine-needle-aspiration-cytology-with-categorisation-using-the-milan-reporting-system
#15
S A Thiryayi, Y X Low, D Shelton, N Narine, D Slater, D N Rana
OBJECTIVE: To assess our practice using the recently developed standardised classification system designated The Milan System for Reporting Salivary Cytopathology (MSRSGC) and to ascertain the rates of malignancy for each category by means of a retrospective study. METHODS: All salivary gland FNA cytology samples received between 1 January 2013 and 31 December 2015 were retrospectively assigned a diagnostic category code from the MSRSGC. Cytology results were correlated with subsequent histology (where available), clinical and radiological follow up...
April 23, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29683530/proximal-type-epithelioid-sarcoma-of-vulva-cytopathological-diagnosis-of-a-rare-neoplasm
#16
Archana Sundaram, Arun Elangovan, Arvind Rajwanshi, Radhika Srinivasan, Rakesh Kapoor
Proximal-type epithelioid sarcoma (PES) is a rare malignant mesenchymal tumour of unknown origin and histogenesis. The exact worldwide incidence is also not reported. Clinically, these tumours commonly present as vague masses involving the deeper soft tissues of proximal sites1 . PES has gained importance recently since it is recognized as a distinct entity with characteristic morphology, immunochemical findings and worse clinical outcomes. This article is protected by copyright. All rights reserved.
April 23, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29680915/medullary-thyroid-carcinoma-application-of-thyroid-imaging-reporting-and-data-system-ti-rads-classification
#17
Gabin Yun, Yeo Koon Kim, Sang Il Choi, Ji-Hoon Kim
PURPOSE: To evaluate the applicability of ultrasound (US)-based Thyroid Imaging Reporting and Data System (TI-RADS) for evaluating medullary thyroid carcinoma (MTC). MATERIALS AND METHODS: US images and medical records of patients with cytopathology-confirmed MTC between June 2003 and November 2016 were retrospectively reviewed. Four independent reviewers (two experienced and two inexperienced radiologists) evaluated 57 pre-operative US images of patients with MTC for shape, composition, echogenicity, margin, calcification of the MTC nodules, and categorized the nodules using TI-RADS classification...
April 21, 2018: Endocrine
https://www.readbyqxmd.com/read/29672463/limited-additional-value-of-cervical-ultrasonography-over-a-negative-18f-fdg-pet-ct-for-diagnosing-cervical-lymph-node-metastases-in-patients-with-esophageal-cancer-a-systematic-review-and-meta-analysis
#18
Lucas Goense, Jihane Meziani, Peter S N van Rossum, Frank J Wessels, Gert J Meijer, Marnix G E H Lam, Richard van Hillegersberg, Jelle P Ruurda
OBJECTIVE: To assess the additional value of cervical ultrasonography as supplement to a negative fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) for detecting cervical lymph node metastases during the initial staging of patients with esophageal cancer. METHODS: PubMed/Medline, Embase, and the Cochrane library were systematically searched. The analysis included diagnostic studies describing the accuracy of cervical ultrasonography and integrated F-FDG PET/CT or standalone F-FDG PET and CT for detecting cervical lymph node metastases in patients with esophageal cancer...
April 18, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29669313/role-of-fna-and-special-stains-in-rapid-cytopathological-diagnosis-of-pulmonary-nocardiosis
#19
Ridhi Sood, Ruchita Tyagi, Pavneet Kaur Selhi, Gursheen Kaur, Harpreet Kaur, Akashdeep Singh
BACKGROUND: Nocardia, a gram-positive aerobic bacillus of the Actinomycetales family, is a significant opportunistic pathogen in immunocompromised individuals. Clinical and radiological features of pulmonary nocardiosis are nonspecific and can be misdiagnosed as tuberculosis, pneumocystis, staphylococcal or fungal infections, or as malignancy. Aspiration cytology with special stains is a quick and effective approach for accurate diagnosis. MATERIALS AND METHODS: We present 7 cases of pulmonary nocardiosis, admitted to the pathology department in a tertiary-care hospital in Punjab...
April 18, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29669190/analysis-of-histologic-follow-up-and-risk-of-malignancy-for-salivary-gland-neoplasm-of-uncertain-malignant-potential-proposed-by-the-milan-system-for-reporting-salivary-gland-cytopathology
#20
Haiyan Liu, Clarissa Ljungren, Fan Lin, Matthew A Zarka, Longwen Chen
BACKGROUND: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. The objective of this study was to assess the risk of malignancy (ROM) of NUMP. METHODS: A retrospective analysis was conducted on 656 salivary gland fine-needle aspiration specimens from 2010 to 2016...
April 18, 2018: Cancer Cytopathology
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