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Cytopathology

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https://www.readbyqxmd.com/read/28079803/high-resolution-endoscopic-ultrasound-imaging-and-the-number-of-needle-passages-are-significant-factors-predicting-high-yield-of-endoscopic-ultrasound-guided-fine-needle-aspiration-for-pancreatic-solid-masses-without-an-on-site-cytopathologist
#1
Seok Hoo Jeong, Hyun Hwa Yoon, Eui Joo Kim, Yoon Jae Kim, Yeon Suk Kim, Jae Hee Cho
Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is the accurate diagnostic method for pancreatic masses and its accuracy is affected by various FNA methods and EUS equipment. Therefore, we aimed to elucidate the instrumental and methodologic factors for determining the diagnostic yield of EUS-FNA for pancreatic solid masses without an on-site cytopathology evaluation.We retrospectively reviewed the medical records of 260 patients (265 pancreatic solid masses) who underwent EUS-FNA. We compared historical conventional EUS groups with high-resolution imaging devices and finally analyzed various factors affecting EUS-FNA accuracy...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28071987/a-computer-aided-diagnosis-system-using-artificial-intelligence-for-the-diagnosis-and-characterization-of-thyroid-nodules-on-ultrasound-initial-clinical-assessment
#2
Young Jun Choi, Jung Hwan Baek, Hye Sun Park, Woo Hyun Shim, Tae Yong Kim, YoungKee Shong, Jeong Hyun Lee
Background We describe an initial clinical assessment of a new, commercially available, computer-aided diagnosis (CAD) system using artificial intelligence (AI) for thyroid ultrasound, and evaluate its performance in the diagnosis of malignant thyroid nodules and categorization of nodule characteristics. Methods This prospective study protocol was reviewed and approved by the institutional review board. Patients with thyroid nodules with decisive diagnosis, whether benign or malignant on the basis of cytopathologic or US results, were consecutively enrolled from November 2015 to February 2016...
January 10, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28064107/ethnomedicine-based-evaluation-of-osteoprotective-properties-of-tinospora-cordifolia-on-in-vitro-and-in-vivo-model-systems
#3
G Abiramasundari, C M Mohan Gowda, G Pampapathi, Sheela Praveen, S Shivamurugan, M Vijaykumar, A Devi, M Sreepriya
Indian ethnomedicine acclaims the use of Tinospora cordifolia (TC) in the treatment of bone fractures and vat rakta (gout). The objective of the study is to investigate the effects of alcoholic extract of Tinospora cordifolia on bone remodeling (involving osteoblastic and osteoclastic actions) in vitro and protect against ovariectomy-induced bone loss in vivo. Human osteoblast-like cells MG-63 and primary osteoblast cells isolated from rat femur were used as osteoblast models and RAW macrophage cell line 264...
January 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28060147/myomelanocytic-choroidal-tumor-cytopathologic-diagnosis
#4
Ian M Jaffee, Devron H Char
PURPOSE: Establishing the correct diagnosis of a growing choroidal tumor can be difficult. METHODS: Clinical examination and ultrasound of a patient followed for what was thought to be a uveal melanoma. Fine-needle biopsy established the correct diagnosis. RESULTS: We demonstrate that fine-needle biopsy can correctly identify a very rare tumor, a myomelanocytic neoplasm. CONCLUSION: Myomelanocytic choroidal tumors can be diagnosed on fine-needle biopsy...
January 2, 2017: Retina
https://www.readbyqxmd.com/read/28059233/cytopathological-image-analysis-using-deep-learning-networks-in-microfluidic-microscopy
#5
G Gopakumar, K Hari Babu, Deepak Mishra, Sai Siva Gorthi, Gorthi R K Sai Subrahmanyam
Cytopathologic testing is one of the most critical steps in the diagnosis of diseases, including cancer. However, the task is laborious and demands skill. Associated high cost and low throughput drew considerable interest in automating the testing process. Several neural network architectures were designed to provide human expertise to machines. In this paper, we explore and propose the feasibility of using deep-learning networks for cytopathologic analysis by performing the classification of three important unlabeled, unstained leukemia cell lines (K562, MOLT, and HL60)...
January 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/28059116/further-characterization-of-maize-chlorotic-mottle-virus-and-its-synergistic-interaction-with-sugarcane-mosaic-virus-in-maize
#6
Qiang Wang, Chao Zhang, Chunyan Wang, Yajuan Qian, Zhenghe Li, Jian Hong, Xueping Zhou
Maize chlorotic mottle virus (MCMV) was first reported in maize in China in 2009. In this study we further analyzed the epidemiology of MCMV and corn lethal necrosis disease (CLND) in China. We determined that CLND observed in China was caused by co-infection of MCMV and sugarcane mosaic virus (SCMV). Phylogenetic analysis using four full-length MCMV cDNA sequences obtained in this study and the available MCMV sequences retrieved from GenBank indicated that Chinese MCMV isolates were derived from the same source...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28052107/ubiquitin-accumulation-on-disease-associated-protein-aggregates-is-correlated-with-nuclear-ubiquitin-depletion-histone-de-ubiquitination-and-impaired-dna-damage-response
#7
Adi Ben Yehuda, Marwa Risheq, Ofra Novoplansky, Kirill Bersuker, Ron R Kopito, Michal Goldberg, Michael Brandeis
Deposition of ubiquitin conjugates on inclusion bodies composed of protein aggregates is a definitive cytopathological hallmark of neurodegenerative diseases. We show that accumulation of ubiquitin on polyQ IB, associated with Huntington's disease, is correlated with extensive depletion of nuclear ubiquitin and histone de-ubiquitination. Histone ubiquitination plays major roles in chromatin regulation and DNA repair. Accordingly, we observe that cells expressing IB fail to respond to radiomimetic DNA damage, to induce gamma-H2AX phosphorylation and to recruit 53BP1 to damaged foci...
2017: PloS One
https://www.readbyqxmd.com/read/28051837/melanotic-neuroectodermal-tumor-of-infancy-cytology-and-histopathology-of-a-rare-lesion-at-an-uncommon-site
#8
Nishant Batta, Vikram Narang, Harpreet Kaur, Pavneet Kaur Selhi, Neena Sood
Melanotic neuroectodermal tumour of infancy is a rare, pigmented neoplasm generally arising in infants during the first year of life. The cytological features are rarely described in the literature. This case due to its rarity and unusual site emphasising the cytopathological features and the necessity of histology for differentiating it from other round cell tumours has been presented. Diagn. Cytopathol. 2016. © 2016 Wiley Periodicals, Inc.
November 7, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28051368/diagnostic-pediatric-cytopathology-and-histopathologic-correlation
#9
Lauren Parsons
No abstract text is available yet for this article.
November 2016: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28050379/pulmonary-hamartoma-mimicking-malignancy-a-cytopathological-diagnosis
#10
Manjari Kishore, Prajwala Gupta, Preeti, Desh Deepak
Pulmonary Hamartomas (PH) are benign tumour-like lesions of lung with an uncommon occurrence and pose a diagnostic challenge on chest radiograph. Fine Needle Aspiration Cytology (FNAC) can lead to a definitive diagnosis as well as distinguishes these from malignant lung mass. Most of the patients are asymptomatic and incidentally detected on routine chest radiographs. We report a case of pulmonary hamartoma where the patient was symptomatic and a possibility of malignant neoplasm was considered until the FNAC concluded the diagnosis...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28042957/papanicolaou-society-of-cytopathology-new-guidelines-have-a-greater-ability-of-risk-stratification-for-pancreatic-endoscopic-ultrasound-guided-fine-needle-aspiration-specimens
#11
Bo Chen, Yu Zhao, Jiangang Gu, Huanwen Wu, Zhiyong Liang, Zhilan Meng
The Papanicolaou Society of Cytopathology has recently proposed a standardized terminology and nomenclature guidelines for pancreatic cytology. However the risk of malignancy associated with the new guidelines has been scarcely studied. In this study, a series of pancreatic cytology cases obtained by endoscopic ultrasound-guided fine-needle aspiration from 294 Chinese patients were retrospectively re-categorized into six categories according the new guidelines. The risks of malignancy were 18.1% for "negative," 20...
December 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/28028345/subcutaneous-pheohyphomycois-a-rare-mycotic-infection-from-a-north-himalayan-state-of-india-diagnosed-on-cytopathology
#12
Smita Chandra, Vaidehi Vaidya, Meena Harsh, Harish Chandra, Rashmi Jindal
No abstract text is available yet for this article.
October 2016: Journal of Cytology
https://www.readbyqxmd.com/read/28028338/cytological-diagnosis-of-pediatric-thyroid-nodule-in-perspective-of-the-bethesda-system-for-reporting-thyroid-cytopathology
#13
Chayanika Pantola, Sanjay Kala, Lubna Khan, Saurabh Pantola, Mahendra Singh, Sumanlata Verma
BACKGROUND: Thyroid nodule is one of the most common endocrinopathies occurring children and adolescents. Though thyroid nodule is rare in the pediatric age group, the rate of malignancy is much higher in this age group compared to adult population. AIM: The objective is to study the application of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) in pediatric patients and compare the findings with histology. MATERIALS AND METHODS: A total of 218 cases younger than 18 years were studied in a 4-year period from August 2010 to July 2014...
October 2016: Journal of Cytology
https://www.readbyqxmd.com/read/28025154/increasing-number-of-passes-beyond-4-does-not-increase-sensitivity-of-detection-of-pancreatic-malignancy-by-endoscopic-ultrasound-guided-fine-needle-aspiration
#14
Mehdi Mohamadnejad, Daniel Mullady, Dayna S Early, Brian Collins, Carrie Marshall, Sharon Sams, Roy Yen, Mona Rizeq, Maria Romanas, Samia Nawaz, Ozlem Ulusarac, Thomas Hollander, Robert H Wilson, Violette C Simon, Vladimir Kushnir, Stuart K Amateau, Brian C Brauer, Srinivas Gaddam, Riad R Azar, Srinadh Komanduri, Raj Shah, Ananya Das, Steven Edmundowicz, V Raman Muthusamy, Amit Rastogi, Sachin Wani
BACKGROUND & AIMS: It is not clear exactly how many passes are required to determine whether pancreatic masses are malignant using endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). We aimed to define the per-pass diagnostic yield of EUS-FNA for establishing the malignancy of a pancreatic mass, and identify factors associated with detection of malignancies. METHODS: In a prospective study, 239 patients with solid pancreatic masses were randomly assigned to groups that underwent EUS-FNA, with the number of passes determined by an on-site cytopathology evaluation or set at 7 passes, at 3 tertiary referral centers...
December 23, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28011575/molecular-cytopathology
#15
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Anticancer Research
https://www.readbyqxmd.com/read/28005633/twenty-five-gauge-cannula-assisted-fine-needle-aspiration-biopsy-of-choroidal-melanoma-cytopathological-analysis
#16
Arun D Singh, Hassan A Aziz, David Pelayes, Charles V Biscotti
PURPOSE: To report cytopathological observations on the cells retrieved from the 25-G cannula used during prognostic transvitreal fine-needle aspiration biopsy of choroidal melanoma. METHODS: Transvitreal fine-needle aspiration biopsy of choroidal melanoma was performed through a 25-G valved cannula. Twenty samples from 20 consecutive patients were obtained. Most tumors were treated with plaque radiation therapy (16/20, 80%) following standard clinical guidelines...
December 21, 2016: Retina
https://www.readbyqxmd.com/read/27995180/endoscopic-ultrasound-guided-fine-needle-aspiration-plus-kras-and-gnas-mutation-in-malignant-intraductal-papillary-mucinous-neoplasm-of-the-pancreas
#17
Barbara Bournet, Alix Vignolle-Vidoni, David Grand, Céline Roques, Florence Breibach, Jérome Cros, Fabrice Muscari, Nicolas Carrère, Janick Selves, Pierre Cordelier, Louis Buscail
Background:KRAS and GNAS mutations are common in intraductal papillary mucinous neoplasia of the pancreas (IPMN). The aims of this study were to assess the role of pre-therapeutic cytopathology combined with KRAS and GNAS mutation assays within cystic fluid sampled by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) to predict malignancy of IPMN. Patients and methods: We prospectively included 37 IPMN patients with clinical and/or imaging predictors of malignancy (men: 24; mean age: 69.5 years)...
December 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27991910/establishment-and-characterization-of-bhd-f59rsvt-an-immortalized-cell-line-derived-from-a-renal-cell-carcinoma-in-a-patient-with-birt-hogg-dub%C3%A3-syndrome
#18
Mitsuko Furuya, Hisashi Hasumi, Masaya Baba, Reiko Tanaka, Yasuhiro Iribe, Takahiro Onishi, Yoji Nagashima, Yukio Nakatani, Yasuhiro Isono, Masahiro Yao
Hereditary renal cell carcinomas (RCCs) are life-threatening disorders not only for the patients but also for their relatives. Birt-Hogg-Dubé syndrome (BHD) is an autosomal dominant disorder caused by germline mutations in the folliculin gene (FLCN). The protein product, FLCN, functions as a tumor suppressor, and the affected patients have high risks of developing multiple RCCs. The carcinogenic mechanisms stemming from FLCN dysfunction have been investigated using rodent models and human RCC tissues. However, very limited information has been available about in vitro signaling of human renal cells with genetically mutant FLCN...
December 19, 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27977080/an-inside-look-at-cancer-cytopathology
#19
Esmeralda Galán Buchanan, Daniel E Nadolny
No abstract text is available yet for this article.
December 2016: Cancer
https://www.readbyqxmd.com/read/27976423/mohs-micrographic-surgery-of-rare-cutaneous-tumors
#20
Sophie C Flohil, Charlotte B van Lee, Jessica Beisenherz, Marc A M Mureau, Lucy I H Overbeek, Tamar Nijsten, Renate R van den Bos
BACKGROUND: Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumors are poorly defined. OBJECTIVE: Investigate the recurrence rate after MMS for rare cutaneous tumors at a university center. METHODS & MATERIALS: Retrospective review of all rare cutaneous tumors treated with MMS at a large university center between January 2008 and December 2012. To detect all recurrences, patients were linked to The nationwide network and registry of histo- and cytopathology (PALGA)...
December 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
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