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Orbital tumor

Swati Singh, Swathi Kaliki, Vijay Anand Reddy Palkonda, Milind N Naik
BACKGROUND: Langerhans cell histiocytosis (LCH) of the orbit is a rare clinical entity with a diagnostic and therapeutic dilemma. MATERIALS AND METHODS: This was a retrospective study of eight patients with orbital LCH. RESULTS: All eight patients in our series were male, and the mean age at presentation was 8 years (median 6 years; range, 7 months-23 years). All of them had unilateral disease, and the most common presenting complaint was upper eyelid swelling ( n = 6)...
May 2018: Oman Journal of Ophthalmology
Jianping Wang, Di Zhang, Xiaojie Fu, Lie Yu, Zhengfang Lu, Yufeng Gao, Xianliang Liu, Jiang Man, Sijia Li, Nan Li, Xuemei Chen, Michael Hong, Qingwu Yang, Jian Wang
BACKGROUND: At low levels, carbon monoxide (CO) has been shown to have beneficial effects on multiple organs and tissues through its potential anti-inflammatory, anti-apoptotic, and anti-proliferative properties. However, the effect of CO-releasing molecule (CORM)-3, a water-soluble CORM, on ischemic stroke and its mechanism of action are still unclear. METHODS: We investigated the role of CORM-3 in the mouse model of transient middle cerebral artery occlusion (tMCAO)...
June 21, 2018: Journal of Neuroinflammation
Chryssa Terzidou, Alexandra Trivli, Georgios Dalianis, Dimitra Apessou, Demetrios A Spandidos, George N Goulielmos
Choroidal melanoma is a rare ocular tumor. The present study reports the case of a 66-year-old male who presented with chronic headache and progressive visual loss. Physical eye examination and combined A- and B-mode ultrasonography detected choroidal melanoma. Due to tumor characteristics the eye was enucleated restoring the orbital volume with a 22 mm intraorbital bioceramic sphere implant. The eye was subjected to histopathological examination that confirmed the choroidal melanoma, 2 cm in diameter and 0...
July 2018: Oncology Letters
Liverana Lauretti, Quintino Giorgio D'Alessandris, Mario Rigante, Luca Ricciardi, Pier Paolo Mattogno, Alessandro Olivi
BACKGROUND: In transsphenoidal endoscopic cranial base surgery, a precise navigational support may be crucial. This is particularly evident in case of tumors extending to the parasellar region or in recurrent tumors whereas the normal anatomy has been altered by previous surgery/radiotherapy. METHODS: Previous unsatisfactory experiences with a variety of navigation techniques in this type of surgery, encouraged us to perform an endoscopic endonasal approach with an OArm® (Medtronic, Inc...
June 11, 2018: World Neurosurgery
Pravin Salunke, Sushanta K Sahoo, Apinderpreeet Singh, Nishant Yagnik
The anterior clinoidal meningiomas often engulf /encase or compress Internal Carotid artery (ICA) and its branches, Optic nerve (ON) and structures passing through superior orbital fissure (SOF). The trans-sylvain route of excising tumour poses a difficulty in exposing and safeguarding encased vessels. In addition, it may jeopardize the bulging brain and stretched veins, especially in large tumors. The objective is to present an operative video to demonstrate the technique of 'centrifugal opening' and removal of anterior clinoidal meningiomas...
June 11, 2018: World Neurosurgery
Erica K Low, Egil Brudvik, Bradford Mitchell Kuhlman, Paul F Wilson, Graca M Almeida-Porada, Christopher D Porada
Astronauts on missions beyond low-Earth orbit are exposed to a hostile environment in which they are continually bombarded with unique high-energy species of radiation, while in conditions of microgravity (G), which can alter radiation response and immunity. In the present studies, we examined the impact exposing human hematopoietic stem/progenitor cells (HSC) to μG had upon their capacity to repair DNA damage and their ability to generate immune cells critical for mounting an effective anti-tumor response...
June 14, 2018: Stem Cells and Development
Akimasa Takahashi, Manabu Kurosawa, Mao Uemura, Jun Kitazawa, Yoshihiko Hayashi
Inflammatory myofibroblastic tumors (IMTs) are neoplasms with low malignant potential, and the most common tumor in the lung and orbit. Their occurrence in the uterus is rare. Approximately 50% of IMT patients have anaplastic lymphoma kinase gene ( ALK) rearrangements. Recent studies described novel fusions involving ROS1, platelet-derived growth factor receptor beta ( PDGFR-β), and ETS translocation variant ( ETV6) genes in a subset of ALK-negative patients. We report a 44-year-old woman with anemia and uterine IMT...
January 1, 2018: Journal of International Medical Research
Deliang L Liu, Zhuojun J Zheng
This study sought to explore the prognostic factors in a large retrospective cohort of patients with B-cell primary ocular lymphoma (POL) from the Surveillance, Epidemiology, and End Results database. There were 2778 patients with B-cell POL whose complete clinical information was listed in the Surveillance, Epidemiology, and End Results database between 1997 and 2014. The epidemiology, therapeutic measures, and clinical characteristics were listed as descriptive statistics. Survival analysis was conducted by univariate and multivariable Cox regression models...
June 12, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Fanglin He, Yuxin Wang, Renbin Jia
BACKGROUND: Malignant melanoma predominantly occurs in whites, and is potentially fatal. Distant metastases often occur in lung, liver, brain, and could occur without prior regional disease. Conjunctival melanoma metastasis to contralateral orbit has never been reported. PATIENT PRESENTATION: A 60-year-old man who underwent a left primary conjunctival neoplasm resection 11 months ago presented for the evaluation of a conjunctival dark-colored mass with a bulging left lower eyelid that directly invaded the orbits bilaterally...
June 11, 2018: Journal of Craniofacial Surgery
J Brour, H Sassi, W Koubaa Mahjoub, M Ouederni, A Hassairi, A Chedly Debbiche, M Chéour
INTRODUCTION: Hyper-IgG4 syndrome is a rare cause of bilateral proptosis. It must always be considered after ruling out orbital lymphoma. CASE REPORT: We report a case of progressive bilateral proptosis for 4 years in a 34-year-old man. Orbital MRI showed an infiltrative process extending to the orbital fat, extraocular muscles and lacrimal glands. Lacrimal gland biopsy with immunohistochemical study showed a lymphoplasmocytic infiltrate rich in IgG4 and fibrosis...
June 7, 2018: Journal Français D'ophtalmologie
Kelsey A Roelofs, Shaun Medlicott, Jan-Willem Henning, Ezekiel Weis
A 66-year-old woman was referred to the authors' service with a 1-week history of blurry vision in her left eye and retro-orbital ache. She had previously undergone a radical distal gastrectomy and omentectomy for gastrointestinal stromal tumor, epithelioid type, 7 years prior. Exophthalmometry confirmed 2 mm of left-sided proptosis. Computed tomography imaging revealed a solid-appearing mass straddling both the intra- and extraconal spaces and involving the superior rectus muscle. An excisional biopsy was performed...
June 6, 2018: Ophthalmic Plastic and Reconstructive Surgery
Shuyao Li, Shuwei Liu, Lu Wang, Min Lin, Rui Ge, Xing Li, Xue Zhang, Yi Liu, Lening Zhang, Hongchen Sun, Hao Zhang, Bai Yang
Polypyrrole (PPy) nanoparticles (NPs) possess high near-infrared absorption and good biosafety, showing the potentials as photothermal therapeutic materials. However, the single function and the weak diagnostic function limit the further combination with other functional units to achieve theranostics. In this work, polyaminopyrrole (PPy-NH2 ) is demonstrated as the alternative of PPy for preparing NPs. Because of the amino group, metal ions, such as Cu(II) and Fe(III) can be loaded in PPy-NH2 NPs, which extends the applications in multimodal theranostics...
2018: Nanotheranostics
Abbas Bagheri, Mohammad Abbaszadeh, Peyman Torbati, Mozhgan Rezaei Kanavi
Mesenchymal chondrosarcoma (MCS) is a rare tumor in the orbit. Although optic nerve displacement is a common finding in intraorbital MCS, optic nerve tissue involvement in tumor has rarely been reported in huge tumors associated with intracranial extension. Herein the authors report a patient with MCS involving optic nerve tissue without intracranial extension. A 59-year-old woman with a 2-month history of progressive proptosis and normal vision presented to us. Computed tomography revealed a clearly outlined heterogeneous mass with calcified foci in its center, which was attached to the optic nerve, magnetic resonance imaging showed the mass to be isointense to gray matter on T1- and T2-weighted images...
May 31, 2018: Journal of Craniofacial Surgery
Swathi Kaliki, Shikha Taneja, Vijay A R Palkonda
PURPOSE: To study the clinical presentation and treatment outcome of patients who underwent inadvertent intraocular surgery before the diagnosis of retinoblastoma. DESIGN: Retrospective study of 14 patients who had undergone an inadvertent intraocular surgery before the diagnosis of retinoblastoma. RESULTS: The mean age at presentation to the ocular oncology clinic was 69 months. The most common initial misdiagnosis was endophthalmitis (n = 4)...
May 8, 2018: Retina
Katharine S Dempsey, Norman C Charles, Irina Belinsky
A 74-year-old man presenting with proptosis and orbital inflammation was found on magnetic resonance imaging to have a unilateral intraconal mass. Biopsy revealed a high-grade malignant tumor that was interpreted as squamous cell carcinoma. Positron emission tomography-computed tomography imaging subsequently identified a primary lesion in the esophagus. Esophageal squamous cell carcinoma is a rare cause of orbital metastasis, with only 4 previously reported cases. The authors discuss an approach to orbital malignancies of obscure origin...
May 18, 2018: Ophthalmic Plastic and Reconstructive Surgery
W X Yeo, K K Tan
Teratomas are the most common germ cell tumors of childhood. Head and neck teratomas, however, account for less than five percent of all teratomas. Considered rare at an incidence of 1 in 20,000 to 40,000 live births, they may occur in the cervical region, nasopharynx, brain, orbit, or oropharynx. Teratoma presenting as an isolated intranasal mass is extremely rare. In this report, we describe a case of a mature teratoma arising from the roof of the nasal cavity presenting as an isolated intranasal mass, the first of its kind from our literature review...
2018: Case Reports in Otolaryngology
Natasha Ferreira Santos da Cruz, Carolina Ando Matsuno, Sérgio Ferreira Santos da Cruz, Aline Pimentel de Miranda, José Vital Filho
Undifferentiated pleomorphic sarcoma (UPS) is an extremely rare tumor that occurs in the head and neck region. Here, we report a unique case of a primary undifferentiated pleomorphic sarcoma in the orbital region. A 35-year-old woman presented with a progressive proptosis and periocular edema for 1 year. She had no previous history of surgery, skin malignancy, or radiation. Imaging tests showed an extraconal mass, not involving the muscles. The tumor was surgically removed and adjuvant radiotherapy was required after histological examination, which showed an undifferentiated pleomorphic sarcoma of the orbit...
April 2018: Arquivos Brasileiros de Oftalmologia
Thomas Stahnke, Ngoy Kilangalanga, Steffi Knappe, Rudolf F Guthoff, Andreas Erbersdobler
Carcinoma of the conjunctiva is a malignant tumor which is mostly detected and surgically treated at an early stage because of medical or cosmetic problems. Exceptions of this rule may occur in developing countries, where patients do not have access to standard medical care systems. We report the case of a conjunctival carcinoma in an African patient with an unusually late presentation. Because of local medical shortcomings, and considering the severe, transmural inflammation of anterior ocular structures, an exenteration was performed although the orbit was not deeply involved with the tumor...
2018: Case Reports in Ophthalmological Medicine
Xiao-Quan Xu, Wen Qian, Hao Hu, Guo-Yi Su, Hu Liu, Hai-Bin Shi, Fei-Yun Wu
Background Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been used for assessing orbital lymphoproliferative disorders (OLPDs). However, only the mean values of quantitative parameters were obtained in previous studies and tumor heterogeneity was ignored. Purpose To assess the value of DCE-MRI derived histogram parameters in differentiating malignant from benign OLPDs. Material and Methods Forty-eight OLPDs patients (25 malignant and 23 benign) who had undergone DCE-MRI for pre-treatment evaluation were retrospectively included...
January 1, 2018: Acta Radiologica
Verónica Pérez, Claudia Sampor, Guadalupe Rey, Andreu Parareda-Salles, Katherine Kopp, Agustín P Dabezies, Gustavo Dufort, Marta Zelter, Juan P López, Marcelo Urbieta, Elisa Alcalde-Ruiz, Jaume Catala-Mora, Mariona Suñol, Diego Ossandon, Adriana C Fandiño, J Oscar Croxatto, María T G de Dávila, Gregory Reaman, Yaddanapudi Ravindranath, Guillermo L Chantada
Importance: Multi-institutional collaborative studies that include large patient populations for the management of retinoblastoma with histopathological risk factors could provide important information for patient management. Objective: To evaluate the implementation of a strategy for the management of nonmetastatic unilateral retinoblastoma in children based on standardized diagnostic and treatment criteria. Design, Setting, and Participants: This single-arm prospective study applied a strategy based on a single-center experience...
May 17, 2018: JAMA Ophthalmology
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