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Cardiac telemetry

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https://www.readbyqxmd.com/read/28223123/proarrhythmia-liability-assessment-and-the-comprehensive-in-vitro-proarrhythmia-assay-cipa-an-industry-survey-on-current-practice
#1
Simon Authier, Michael K Pugsley, John E Koerner, Bernard Fermini, William S Redfern, Jean-Pierre Valentin, Hugo M Vargas, Derek J Leishman, Krystle Correll, Michael J Curtis
INTRODUCTION: The Safety Pharmacology Society (SPS) has conducted a survey of its membership to identify industry practices related to testing considered in the Comprehensive In vitro Proarrhythmia Assay (CiPA). METHODS: Survey topics included nonclinical approaches to address proarrhythmia issues, conduct of in silico studies, in vitro ion channel testing methods used, drugs used as positive controls during the conduct of cardiac ion channel studies, types of arrhythmias observed in non-clinical studies and use of the anticipated CiPA ion channel assay...
February 18, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28127832/does-this-patient-need-telemetry-an-analysis-of-telemetry-ordering-practices-at-an-academic-medical-center
#2
Stephanie Chen, Sonali Palchaudhuri, Amber Johnson, Jeff Trost, Ileana Ponor, Sammy Zakaria
INTRODUCTION: The American Heart Association and Choosing Wisely campaign recommend guideline-based usage of telemetry. Inappropriate use leads to increased costs, alarm fatigue, and inefficient nursing care. This study assesses provider ordering practices for telemetry at a US-based academic hospital. METHODS: This retrospective study includes all telemetry orders in the medicine and progressive care units from April 2014 to March 2015. Indications were grouped into categories per American Heart Association guidelines...
January 27, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28065821/an-evaluation-of-the-utility-of-lvdp-dt40-qa-interval-lvdp-dtmin-and-tau-as-indicators-of-drug-induced-changes-in-contractility-and-lusitropy-in-dogs
#3
Michael K Pugsley, Brian Guth, Alan Y Chiang, Jennifer M Doyle, Michael Engwall, Jean-Michel Guillon, Peter K Hoffmann, John E Koerner, Scott W Mittelstadt, Jennifer Beck Pierson, Eric I Rossman, Dustan R Sarazan, Stanley T Parish
INTRODUCTION: The importance of drug-induced effects on the inotropic state of the heart is well known. Unlike hemodynamic and cardiac electrophysiological methods, which have been routinely used in drug safety testing for years, the non-clinical assessment of drug effects on myocardial contractility is used less frequently with no established translation to humans. The goal of these studies was to determine whether assessment of alternate measures of cardiac inotropy could detect drug-induced changes in the contractile state of the heart using drugs known to have clinically relevant positive and negative effects on myocardial contractility...
January 5, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/27999689/bradycardia-associated-with-steroid-use-for-laryngeal-edema-in-an-adult-a-case-report-and-literature-review
#4
Preeti R John, Ariana Khaladj-Ghom, Kimberly L Still
Steroids are used for specific indications in the perioperative period to reduce laryngeal or spinal cord edema, or for prophylaxis and treatment of postoperative nausea and vomiting. Given the other potential causes for hemodynamic alterations in the perioperative setting, it is important for physicians to be aware of cardiovascular side effects of short term steroids. Changes in blood pressure and heart rate, cardiac dysrhythmias, and even death have been described in patients receiving short term intravenous steroids...
2016: Case Reports in Cardiology
https://www.readbyqxmd.com/read/27993561/loss-of-smooth-muscle-cell-disintegrin-and-metalloproteinase-17-transiently-suppresses-angiotensin-ii-induced-hypertension-and-end-organ-damage
#5
Mengcheng Shen, Jude Morton, Sandra T Davidge, Zamaneh Kassiri
Hypertension is associated with hypertrophy and hyperplasia of smooth muscle cells (SMCs). Disintegrin and metalloproteinase 17 (ADAM17) is a membrane-bound enzyme reported to mediate SMC hypertrophy through activation of epidermal growth factor receptor (EGFR). We investigated the role of ADAM17 in Ang II-induced hypertension and end-organ damage. VSMC was isolated from mice with intact ADAM17 expression (Adam17(f/f)) or lacking ADAM17 in the SMC (Adam17(f/f)/Cre(Sm22)). Human VSMCs were isolated from the aorta of donors, and ADAM17 deletion was achieved by siRNA transfection...
December 16, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27964766/both-high-and-low-plasma-levels-of-25-hydroxy-vitamin-d-increase-blood-pressure-in-a-normal-rat-model
#6
Naghmeh Z Mirhosseini, Steven J Knaus, Kaylee Bohaychuk, Jaswant Singh, Hassan A Vatanparast, Lynn P Weber
The lower threshold plasma 25-hydroxy vitamin D (25(OH)D) level for optimal cardiovascular health is unclear, whereas the toxicity threshold is less clear. The aim of this study was to examine the cardiovascular-vitamin D dose-response curve in a normal rat model. Doses of cholecalciferol ranged from deficiency to toxic levels (equivalent to human doses of 0, 0·015, 0·25 and 3·75mg/d) for 4 weeks, and then cardiovascular health was examined using blood pressure telemetry and high-resolution ultrasound in normal male rats (n 16/group, 64 rats total)...
December 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27943326/technologies-for-prolonging-cardiac-implantable-electronic-device-longevity
#7
REVIEW
Ernest W Lau
Prolonged longevity of cardiac implantable electronic devices (CIEDs) is needed not only as a passive response to match the prolonging life expectancy of patient recipients, but will also actively prolong their life expectancy by avoiding/deferring the risks (and costs) associated with device replacement. CIEDs are still exclusively powered by nonrechargeable primary batteries, and energy exhaustion is the dominant and an inevitable cause of device replacement. The longevity of a CIED is thus determined by the attrition rate of its finite energy reserve...
January 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27895190/caveolin-1-deletion-prevents-hypertensive-vascular-remodeling-induced-by-angiotensin-ii
#8
Steven J Forrester, Katherine J Elliott, Tatsuo Kawai, Takashi Obama, Michael J Boyer, Kyle J Preston, Zhen Yan, Satoru Eguchi, Victor Rizzo
It has been proposed that membrane microdomains, caveolae, in vascular cells are critical for signal transduction and downstream functions induced by angiotensin II (AngII). We have tested our hypothesis that caveolin-1 (Cav1), a major structural protein of vascular caveolae, plays a critical role in the development of vascular remodeling by AngII via regulation of epidermal growth factor receptor and vascular endothelial adhesion molecule-1. Cav1(-/-) and control Cav(+/+) mice were infused with AngII for 2 weeks to induce vascular remodeling and hypertension...
January 2017: Hypertension
https://www.readbyqxmd.com/read/27799254/phosphodiesterase-2-protects-against-catecholamine-induced-arrhythmia-and-preserves-contractile-function-after-myocardial-infarction
#9
Christiane Vettel, Marta Lindner, Matthias Dewenter, Kristina Lorenz, Constanze Schanbacher, Merle Riedel, Simon Lämmle, Simone Meinecke, Fleur E Mason, Samuel Sossalla, Andreas Geerts, Michael Hoffmann, Frank Wunder, Fabian J Brunner, Thomas Wieland, Hind Mehel, Sarah Karam, Patrick Lechêne, Jérôme Leroy, Grégoire Vandecasteele, Michael Wagner, Rodolphe Fischmeister, Ali El-Armouche
RATIONALE: Phosphodiesterase 2 (PDE2) is a dual substrate esterase, which has the unique property to be stimulated by cGMP, but primarily hydrolyses cAMP. Myocardial PDE2 is upregulated in human heart failure (HF), but its role in the heart is unknown. OBJECTIVE: To explore the role of PDE2 in cardiac function, propensity to arrhythmia and in myocardial infarction. METHODS AND RESULTS: Pharmacological inhibition of PDE2 (BAY 60-7550, BAY) led to a significant positive chronotropic effect on top of maximal β-adrenoceptor (β-AR) activation in healthy mice...
October 31, 2016: Circulation Research
https://www.readbyqxmd.com/read/27791149/cardiac-arrhythmia-in-a-mouse-model-of-sodium-channel-scn8a-epileptic-encephalopathy
#10
Chad R Frasier, Jacy L Wagnon, Yangyang Oliver Bao, Luke G McVeigh, Luis F Lopez-Santiago, Miriam H Meisler, Lori L Isom
: Patients with early infantile epileptic encephalopathy (EIEE) are at increased risk for sudden unexpected death in epilepsy (SUDEP). De novo mutations of the sodium channel gene SCN8A, encoding the sodium channel Nav1.6, result in EIEE13 (OMIM 614558), which has a 10% risk of SUDEP. Here, we investigated the cardiac phenotype of a mouse model expressing the gain of function EIEE13 patient mutation p.Asn1768Asp in Scn8a (Nav1.6-N1768D). We tested Scn8a(N1768D/+) mice for alterations in cardiac excitability...
October 26, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27784688/high-intensity-interval-training-but-not-continuous-training-reverses-right-ventricular-hypertrophy-and-dysfunction-in-a-rat-model-of-pulmonary-hypertension
#11
Mary Beth Brown, Evandro Neves, Gary Marshall Long, Jeremy Bryce Graber, Brett Alexandria Gladish, Andrew Wiseman, Matthew Owens, Amanda Jo Fisher, Robert Gray Presson, Irina Petrache, Jeffrey A Kline, Tim Lahm
BACKGROUND: Exercise is beneficial in pulmonary arterial hypertension (PAH), although studies to date indicate little effect on the elevated pulmonary pressures or maladaptive RV hypertrophy associated with the disease. For chronic LV failure, high intensity interval training (HIIT) promotes greater endothelial stimulation and superior benefit than customary continuous exercise training (CExT); however, HIIT has not been tested for PAH. Therefore, here we investigated acute and chronic responses to HIIT vs...
October 26, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27756797/sex-differences-in-the-epidemiology-of-new-onset-in-hospital-post-coronary-artery-bypass-graft-surgery-atrial-fibrillation-a-large-multicenter-study
#12
Giovanni Filardo, Gorav Ailawadi, Benjamin D Pollock, Briget da Graca, Danielle M Sass, Teresa K Phan, Debbie E Montenegro, Vinod Thourani, Ralph Damiano
BACKGROUND: New-onset atrial fibrillation (AF) after coronary artery bypass graft surgery (CABG) is associated with increased morbidity and poorer long-term survival. Although many studies show differences in outcome in women versus men after CABG, little is known about the sex-specific incidence and characteristics of post-CABG AF. METHODS AND RESULTS: Overall, 11 236 consecutive patients without preoperative AF underwent isolated CABG from 2002 to 2010 at 4 US academic medical centers and 1 high-volume specialty cardiac hospital...
October 18, 2016: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/27750160/ictal-bradyarrhythmias-and-asystole-requiring-pacemaker-implantation-combined-eeg-ecg-analysis-of-5-cases
#13
Roisin Bartlam, Rajiv Mohanraj
BACKGROUND: Seizures can lead to cardiac arrhythmias by a number of mechanisms including activation/inhibition of cortical autonomic centers, increase in vagal tone through activation of brainstem reflex centers, and respiratory failure. Ictal asystole (IA) is a potential mechanism underlying sudden unexpected death in epilepsy (SUDEP). We analyzed the clinical features of 5 patients who developed IA requiring pacemaker implantation. METHODS: Patients with ictal arrhythmias were identified from the video-telemetry and ambulatory EEG database at Greater Manchester Neurosciences Centre, as well as an independent epilepsy residential care facility...
November 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27747808/incidence-of-sustained-ventricular-tachycardia-in-patients-with-prolonged-qtc-after-the-administration-of-azithromycin-a-retrospective-study
#14
Steven P Sears, Trevor W Getz, Christopher O Austin, William C Palmer, Evelyn A Boyd, Fernando F Stancampiano
BACKGROUND: Azithromycin has been associated with abnormalities of cardiac repolarization and development of torsades de pointes. Observational data suggest that the risk of death from cardiovascular causes is increased in patients taking azithromycin. Little is known regarding the risk of ventricular arrhythmia in patients with prolongation of the corrected QT interval who receive azithromycin. OBJECTIVE: The purpose of this study was to determine the incidence of sustained ventricular tachycardia in patients with prolonged corrected QT (QTc) who subsequently received azithromycin...
March 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27714763/amiselimod-a-novel-sphingosine-1-phosphate-receptor-1-modulator-has-potent-therapeutic-efficacy-for-autoimmune-diseases-with-low-bradycardia-risk
#15
Kunio Sugahara, Yasuhiro Maeda, Kyoko Shimano, Akira Mogami, Hirotoshi Kataoka, Kei Ogawa, Kumiko Hikida, Hiroshi Kumagai, Mahoko Asayama, Toshinobu Yamamoto, Tomohiko Harada, Pingping Ni, Shinsuke Inoue, Atsuhiro Kawaguchi
BACKGROUND AND PURPOSE: We conducted preclinical and clinical studies to examine the pharmacological, particularly cardiac, effects of amiselimod (MT-1303), a second-generation sphingosine 1-phosphate (S1P) receptor modulator, designed to reduce the bradycardia associated with fingolimod and other S1P receptor modulators. EXPERIMENTAL APPROACH: The selectivity of the active metabolite amiselimod phosphate (amiselimod-P) for human S1P receptors and activation of G-protein-coupled inwardly rectifying K(+) (GIRK) channels in human atrial myocytes were assessed...
January 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27712143/mayo-registry-for-telemetry-efficacy-in-arrest-mr-tea-study-an-assessment-of-the-effect-of-admission-diagnosis-on-outcomes-from-in-hospital-cardiopulmonary-arrest
#16
David Snipelisky, Jordan Ray, Gautam Matcha, Archana Roy, Brooke Clark, Adrian Dumitrascu, Veronica Bosworth, Anastasia Whitman, Patricia Lewis, Tyler Vadeboncoeur, Fred Kusumoto, M Caroline Burton
INTRODUCTION: Little data exists evaluating how different risk factors influence outcomes following in-hospital arrests. METHODS: A retrospective review of patients that suffered a cardiopulmonary arrest between 1 May 2008 and 30 June 2014 was performed. Patients were stratified into subsets based on cardiac versus non-cardiac reasons for admission. RESULTS: 199 patients met inclusion criteria, of which 138 (69.3%) had a non-cardiac reason for admission and 61 (30...
December 2015: Acute Cardiac Care
https://www.readbyqxmd.com/read/27688235/location-of-in-hospital-cardiac-arrest-in-the-united-states-variability-in-event-rate-and-outcomes
#17
Sarah M Perman, Emily Stanton, Jasmeet Soar, Robert A Berg, Michael W Donnino, Mark E Mikkelsen, Dana P Edelson, Matthew M Churpek, Lin Yang, Raina M Merchant
BACKGROUND: In-hospital cardiac arrest (IHCA) is a major public health problem with significant mortality. A better understanding of where IHCA occurs in hospitals (intensive care unit [ICU] versus monitored ward [telemetry] versus unmonitored ward) could inform strategies for reducing preventable deaths. METHODS AND RESULTS: This is a retrospective study of adult IHCA events in the Get with the Guidelines-Resuscitation database from January 2003 to September 2010...
September 29, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27603665/a-translational-study-of-a-new-therapeutic-approach-for-acute-myocardial-infarction-nanoparticle-mediated-delivery-of-pitavastatin-into-reperfused-myocardium-reduces-ischemia-reperfusion-injury-in-a-preclinical-porcine-model
#18
Kenzo Ichimura, Tetsuya Matoba, Kaku Nakano, Masaki Tokutome, Katsuya Honda, Jun-Ichiro Koga, Kensuke Egashira
BACKGROUND: There is an unmet need to develop an innovative cardioprotective modality for acute myocardial infarction, for which interventional reperfusion therapy is hampered by ischemia-reperfusion (IR) injury. We recently reported that bioabsorbable poly(lactic acid/glycolic acid) (PLGA) nanoparticle-mediated treatment with pitavastatin (pitavastatin-NP) exerts a cardioprotective effect in a rat IR injury model by activating the PI3K-Akt pathway and inhibiting inflammation. To obtain preclinical proof-of-concept evidence, in this study, we examined the effect of pitavastatin-NP on myocardial IR injury in conscious and anesthetized pig models...
2016: PloS One
https://www.readbyqxmd.com/read/27592100/role-of-trpa1-in-acute-cardiopulmonary-toxicity-of-inhaled-acrolein
#19
Daniel J Conklin, Petra Haberzettl, Ganapathy Jagatheesan, Maiying Kong, Gary W Hoyle
Acrolein is a highly toxic, volatile, unsaturated aldehyde generated during incomplete combustion as in tobacco smoke and indoor fires. Because the transient receptor potential ankyrin 1 (TRPA1) channel mediates tobacco smoke-induced lung injury, we assessed its role in high-level acrolein-induced toxicity in mice. Acrolein (100-275ppm, 10-30min) caused upper airway epithelial sloughing, bradypnea and oral gasping, hypothermia, cardiac depression and mortality. Male wild-type mice (WT, C57BL/6; 5-52weeks) were significantly more sensitive to high-level acrolein than age-matched, female WT mice...
August 31, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27510951/carotid-sinus-denervation-ameliorates-renovascular-hypertension-in-adult-wistar-rats
#20
Wioletta Pijacka, Fiona D McBryde, Paul J Marvar, Gisele S Lincevicius, Ana P L Abdala, Lavinia Woodward, Dan Li, David J Paterson, Julian F R Paton
KEY POINTS: Peripheral chemoreflex sensitization is a feature of renovascular hypertension. Carotid sinus nerve denervation (CSD) has recently been shown to relieve hypertension and reduce sympathetic activity in other rat models of hypertension. We show that CSD in renovascular hypertension halts further increases in blood pressure. Possible mechanisms include improvements in baroreceptor reflex sensitivity and renal function, restoration of cardiac calcium signalling towards control levels, and reduced neural inflammation...
November 1, 2016: Journal of Physiology
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