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Cardiac telemetry

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https://www.readbyqxmd.com/read/29759717/low-level-vagus-nerve-stimulation-suppresses-post-operative-atrial-fibrillation-and-inflammation-a-randomized-study
#1
Stavros Stavrakis, Mary Beth Humphrey, Benjamin Scherlag, Omer Iftikhar, Purvi Parwani, Mubasher Abbas, Adrian Filiberti, Christian Fleming, Yanqing Hu, Paul Garabelli, Arthur McUnu, Marvin Peyton, Sunny S Po
OBJECTIVES: This study sought to examine the efficacy of low-level vagus nerve stimulation (LLVNS) in suppressing post-operative atrial fibrillation (POAF) and inflammatory cytokines in patients undergoing cardiac surgery. BACKGROUND: POAF often complicates cardiac surgery. METHODS: Patients undergoing cardiac surgery were randomized to active or sham LLVNS. In all patients, a bipolar wire was sutured to the vagus nerve pre-ganglionic fibers alongside the lateral aspect of the superior vena cava...
September 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29744993/paroxysmal-complete-atrioventricular-block-in-pediatric-heart-transplant-recipients-following-cardiac-catheterization-a-case-series
#2
Defne A Magnetta, Brian Feingold, Lee B Beerman, Brian Blasiole, Gaurav Arora
Late-onset paroxysmal AVB has been described as a rare complication after HT and has been associated with AR or CAV. We describe 4 pediatric HT recipients who developed paroxysmal AVB hours after routine cardiac catheterization in the absence of AR, CAV, or underlying conduction system disease. Four pediatric HT recipients who were >1 year post-transplant had episodes of paroxysmal AVB hours after surveillance cardiac catheterization with EMB. Telemetry demonstrated high-grade block, ranging from 2:1 AVB to complete AVB without ventricular escape for several seconds...
May 10, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29739759/reflex-anoxic-seizures-ras-in-an-adult-patient-a-separate-entity-from-epilepsy
#3
Laith Cebe, Harpreet Singh
Reflex anoxic seizures (RAS) are essential in the differential diagnosis of non-epileptic paroxysmal seizures. They are precipitated by vagally mediated brief cardiac asystole, which in turn leads to transient cerebral ischaemia. RAS are usually seen in infants and preschool children, but in this case happened in a middle-aged man. Our patient is a 61-year-old man who presented with sudden, repeated contractions of his left upper arm and urine incontinence, followed by loss of consciousness for about 30 s...
May 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29729654/tele-talks-nurse-led-discussions-regarding-need-and-duration-of-cardiac-telemetry-may-impact-alarm-fatigue-empower-nurses-and-reduce-cost
#4
Inga M Zadvinskis, Kelli Schweitzer, Tristan Murry, Teresa Wood
No abstract text is available yet for this article.
May 5, 2018: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/29676623/nicotine-downregulates-the-compensatory-angiotensin-converting-enzyme-2-angiotensin-type-2-receptor-of-the-renin-angiotensin-system
#5
Xinping Yue, Tyler M Basting, Thomas W Flanagan, Jiaxi Xu, Thomas D Lobell, Nicholas W Gilpin, Jason D Gardner, Eric Lazartigues
RATIONALE: Smoking is a major risk factor for the development of cardiovascular and pulmonary diseases. The importance of the renin-angiotensin system in the development of cardiovascular and pulmonary disease is well established. Angiotensin-II, by means of its type 1 receptor (angiotensin type 1 receptor, AT1 R), promotes increased sympathetic activity, salt and water reabsorption, vasoconstriction, inflammation, and aldosterone and vasopressin release, contributing to tissue fibrosis, endothelium dysfunction, and hypertension...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29674325/adenylate-cyclase-type-9-adcy9-inactivation-protects-from-atherosclerosis-only-in-the-absence-of-cholesteryl-ester-transfer-protein-cetp
#6
Yohann Rautureau, Vanessa Deschambault, Marie-Ève Higgins, Daniel Rivas, Mélanie Mecteau, Pascale Geoffroy, Géraldine Miquel, Kurunradeth Uy, Rocio Sanchez, Véronique Lavoie, Geneviève Brand, Audrey Nault, Pierre-Marc Williams, Maria Laura Suarez, Nolwenn Merlet, Line Lapointe, Natacha Duquette, Marc-Antoine Gillis, Samaneh Samami, Gaétan Mayer, Philippe Pouliot, Adeline Raignault, Foued Maafi, Mathieu R Brodeur, Sylvie Levesque, Marie-Claude Guertin, Marie-Pierre Dubé, Éric Thorin, David Rhainds, Éric Rhéaume, Jean-Claude Tardif
Background -Pharmacogenomic studies have shown that ADCY9 genotype determines the effects of the cholesteryl ester transfer protein (CETP) inhibitor dalcetrapib on cardiovascular events and atherosclerosis imaging. The underlying mechanisms responsible for the interactions between ADCY9 and CETP activity have not yet been determined. Methods - Adcy9 -inactivated ( Adcy9 Gt/Gt ) and wild-type (WT) mice, that were or not transgenic for the CETP gene (CETPtg Adcy9 Gt/Gt and CETPtg Adcy9 WT ), were submitted to an atherogenic protocol (injection of an AAV8 expressing a PCSK9 gain-of-function variant and 0...
April 19, 2018: Circulation
https://www.readbyqxmd.com/read/29628472/hcn4-overexpressing-mouse-embryonic-stem-cell-derived-cardiomyocytes-generate-a-new-rapid-rhythm-in-rats-with-bradycardia
#7
Yukihiro Saito, Kazufumi Nakamura, Masashi Yoshida, Hiroki Sugiyama, Makoto Takano, Satoshi Nagase, Hiroshi Morita, Kengo F Kusano, Hiroshi Ito
A biological pacemaker is expected to solve the persisting problems of an artificial cardiac pacemaker including short battery life, lead breaks, infection, and electromagnetic interference. We previously reported HCN4 overexpression enhances pacemaking ability of mouse embryonic stem cell-derived cardiomyocytes (mESC-CMs) in vitro. However, the effect of these cells on bradycardia in vivo has remained unclear. Therefore, we transplanted HCN4-overexpressing mESC-CMs into bradycardia model animals and investigated whether they could function as a biological pacemaker...
April 6, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29595874/temporal-analysis-of-cardiovascular-control-and-function-following-incomplete-t3-and-t10-spinal-cord-injury-in-rodents
#8
Kathryn A Harman, Gregory States, Abigail Wade, Chad Stepp, Grace Wainwright, Kathryn DeVeau, Nicholas King, Alice Shum-Siu, David S K Magnuson
Spinal cord injury (SCI) is a devastating condition that results in whole-body dysfunction, notably cardiovascular (CV) disruption and disease. Injury-induced destruction of autonomic pathways in conjunction with a progressive decline in physical fitness contribute to the poor CV status of SCI individuals. Despite the wide use of exercise training as a therapeutic option to reduce CV dysfunction, little is known about the acute hemodynamic responses to the exercise itself. We investigated CV responses to an exercise challenge (swimming) following both high and low thoracic contusion to determine if the CV system is able to respond appropriately to the challenge of swimming...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29540439/battery-malfunction-of-a-leadless-cardiac-pacemaker-a-worrisome-single-center-experience
#9
Sergio Richter, Michael Döring, Micaela Ebert, Kerstin Bode, Andreas Müssigbrodt, Philipp Sommer, Daniela Husser, Gerhard Hindricks
Leadless cardiac pacemaker (LCP) therapy has been established clinically as a feasible and safe alternative to conventional transvenous pacemaker therapy for patients with an indication for single-chamber right-ventricular pacing.1-3 However, reports on loss of telemetry and pacing output due to abrupt battery failure called the safety of one of the two commercially available systems seriously into question. The initial battery advisory with the Nanostim™ LCP was issued by the manufacturer in October 2016, who instantly called a global stop to Nanostim™ implants...
March 14, 2018: Circulation
https://www.readbyqxmd.com/read/29526834/mobile-phone-detection-of-atrial-fibrillation-with-mechanocardiography-the-mode-af-study-mobile-phone-detection-of-atrial-fibrillation
#10
LETTER
Jussi Jaakkola, Samuli Jaakkola, Olli Lahdenoja, Tero Hurnanen, Tero Koivisto, Mikko Pänkäälä, Timo Knuutila, Tuomas O Kiviniemi, Tuija Vasankari, K E Juhani Airaksinen
No abstract text is available yet for this article.
April 3, 2018: Circulation
https://www.readbyqxmd.com/read/29505899/the-evaluation-of-endpoint-variability-and-implications-for-study-statistical-power-and-sample-size-in-conscious-instrumented-dogs
#11
Alan Y Chiang, Brian D Guth, Michael K Pugsley, C Michael Foley, Jennifer M Doyle, Michael J Engwall, John E Koerner, Stanley T Parish, R Dustan Sarazan
INTRODUCTION: The sensitivity of a given test to detect a treatment-induced effect in a variable of interest is intrinsically related to the variability of that variable observed without treatment and the number of observations made in the study (i.e. number of animals). To evaluate test sensitivity to detect drug-induced changes in myocardial contractility using the variable LVdP/dtmax , a HESI-supported consortium designed and conducted studies in chronically instrumented, conscious dogs using telemetry...
March 2, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29466558/in-hospital-st-segment-elevation-myocardial-infarction-improving-diagnosis-triage-and-treatment
#12
Glenn N Levine, Xuming Dai, Timothy D Henry, Marcella Calfon Press, Ali E Denktas, Ross F Garberich, Alice K Jacobs, Brian E Jaski, Prashant Kaul, Michael C Kontos, George A Stouffer, Sidney C Smith
Importance: In-hospital ST-segment elevation myocardial infarction (STEMI) is a unique clinical entity with epidemiology, incidence, and outcomes distinct from that of out-of-hospital STEMI and has only within the past 10 years begun to receive increased attention and research. Patients with in-hospital STEMI are older, have more comorbidities, and more frequently have coagulopathies and contraindications for anticoagulation and fibrinolytic therapy. A standardized clinical definition of in-hospital STEMI is lacking...
February 21, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29443088/simultaneous-video-eeg-ecg-monitoring-to-identify-neurocardiac-dysfunction-in-mouse-models-of-epilepsy
#13
Vikas Mishra, Nicole M Gautier, Edward Glasscock
In epilepsy, seizures can evoke cardiac rhythm disturbances such as heart rate changes, conduction blocks, asystoles, and arrhythmias, which can potentially increase risk of sudden unexpected death in epilepsy (SUDEP). Electroencephalography (EEG) and electrocardiography (ECG) are widely used clinical diagnostic tools to monitor for abnormal brain and cardiac rhythms in patients. Here, a technique to simultaneously record video, EEG, and ECG in mice to measure behavior, brain, and cardiac activities, respectively, is described...
January 29, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29397284/preservation-of-conductive-propagation-after-surgical-repair-of-cardiac-defects-with-a-bio-engineered-conductive-patch
#14
Sheng He, Huifang Song, Jun Wu, Shu-Hong Li, Richard D Weisel, Hsing-Wen Sung, Jianding Li, Ren-Ke Li
BACKGROUND: Both stable and biodegradable biomaterials have been used to surgically repair congenital cardiac defects. However, neither type of biomaterial can conduct electrical activity. We evaluated the conductivity and efficacy of a newly synthesized conductive polypyrrole-chitosan (Ppy+Chi) gelfoam patch to support cardiomyocyte (CM) viability and function in vitro and to surgically repair a cardiac defect in vivo. METHODS: Ppy+Chi was incorporated into gelfoam (Gel) to form a 3-dimensional conductive patch...
December 20, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29360991/elevated-plasma-catecholamines-functionally-compensate-for-the-reduced-myogenic-tone-in-smooth-muscle-stim1-knockout-mice-but-with-deleterious-cardiac-effects
#15
Prahalathan Pichavaram, Wen Yin, Kirk W Evanson, Jonathan H Jaggar, Salvatore Mancarella
Aims: Stromal interaction molecule 1 (STIM1) has emerged as an important player in the regulation of growth and proliferation of smooth muscle cells. Therefore, we hypothesized that STIM1 plays a crucial role in the maintenance of vascular integrity. The objective of this study was to evaluate whether reduced expression of STIM1 could modify the structure and function of the vasculature, leading to changes in blood pressure (BP). Methods and results: Smooth muscle-specific STIM1 knockout (sm-STIM1 KO) in mice resulted in arteries with ∼80% reduced STIM1 protein expression as compared with control mice...
April 1, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29359574/efficacy-and-safety-of-subcutaneous-neostigmine-for-ileus-acute-colonic-pseudo-obstruction-or-refractory-constipation
#16
Bridgette Kram, Maegan Greenland, Mollie Grant, Michael E Campbell, Charlotte Wells, Courtney Sommer
BACKGROUND: Neostigmine is traditionally administered intravenously for treatment of acute colonic pseudo-obstruction (ACPO), though use is associated with administration constraints and adverse effects. OBJECTIVE: To evaluate whether an alternative route of administration for neostigmine via subcutaneous (SQ) delivery is safe and effective in a broad cohort of medical and surgical patients. METHODS: This multicenter, retrospective observational study included adult patients administered SQ neostigmine for ileus, ACPO, or refractory constipation...
June 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29342227/brain-cytosolic-phospholipase-a2%C3%AE-mediates-angiotensin-ii-induced-hypertension-and-reactive-oxygen-species-production-in-male-mice
#17
Chi Young Song, Nayaab S Khan, Francesca-Fang Liao, Bin Wang, Ji Soo Shin, Joseph V Bonventre, Kafait U Malik
Background: Recently we reported that angiotensin II (Ang II)-induced hypertension is mediated by group IV cytosolic phospholipase A2α (cPLA2α) via production of pro-hypertensive eicosanoids. Since Ang II increases blood pressure via its action in the subfornical organ (SFO), it led us to investigate the expression and possible contribution of cPLA2α to oxidative stress and development of hypertension in this brain area. Methods: Adenovirus (Ad)-green fluorescence protein (GFP) cPLA2α short hairpin (sh) RNA (Ad-cPLA2α shRNA) and its control Ad-scrambled shRNA (Ad-Scr shRNA) or Ad-enhanced cyan fluorescence protein cPLA2α DNA (Ad-cPLA2α DNA) and its control Ad-GFP DNA were transduced into SFO of cPLA2α+/+ and cPLA2α-/- male mice, respectively...
January 12, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29335317/reduced-n-type-ca-2-channels-in-atrioventricular-ganglion-neurons-are-involved-in-ventricular-arrhythmogenesis
#18
Dongze Zhang, Huiyin Tu, Liang Cao, Hong Zheng, Robert L Muelleman, Michael C Wadman, Yu-Long Li
BACKGROUND: Attenuated cardiac vagal activity is associated with ventricular arrhythmogenesis and related mortality in patients with chronic heart failure. Our recent study has shown that expression of N-type Ca2+ channel α-subunits (Cav 2.2-α) and N-type Ca2+ currents are reduced in intracardiac ganglion neurons from rats with chronic heart failure. Rat intracardiac ganglia are divided into the atrioventricular ganglion (AVG) and sinoatrial ganglion. Ventricular myocardium receives projection of neuronal terminals only from the AVG...
January 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29319621/selective-cd28-inhibition-modulates-alloimmunity-and-cardiac-allograft-vasculopathy-in-anti-cd154-treated-monkeys
#19
Tianshu Zhang, Agnes M Azimzadeh, Wenji Sun, Natalie A O'Neill, Evelyn Sievert, Emily Bergbower, Gheorghe Braileanu, Lars Burdorf, Xiangfei Cheng, Thomas Monahan, Siamak Dahi, Donald G Harris, Elana Rybak, Emily Welty, Anthony Kronfli, Chris Avon, Richard N Pierson
BACKGROUND: Selective CD28 inhibition is actively pursued as an alternative to B7 blockade using cytotoxic T lymphocyte antigen 4 Ig based on the hypothesis that the checkpoint immune regulators cytotoxic T lymphocyte antigen 4 and programmed death ligand 1 will induce tolerogenic immune signals. We previously showed that blocking CD28 using a monovalent nonactivating reagent (single-chain anti-CD28 Fv fragment linked to alpha-1 antitrypsin [sc28AT]) synergizes with calcineurin inhibitors in nonhuman primate (NHP) kidney and heart transplantation...
March 2018: Transplantation
https://www.readbyqxmd.com/read/29314105/ambulatory-diagnostic-ecg-monitoring-for-syncope-and-collapse-an-assessment-of-clinical-practice-in-the-united-states
#20
David G Benditt, Wayne O Adkisson, Richard Sutton, Robin K Mears, Scott Sakaguchi
INTRODUCTION: Diagnostic ambulatory electrocardiogram (AECG) monitoring is widely used for evaluating syncope and collapse, and practice guidelines provide recommendations regarding optimal AECG device selection. However, whether physicians utilize AECGs in accordance with the pertinent guidelines is unclear. This study assessed utilization of AECG monitoring systems for syncope and collapse diagnosis by physicians in the United States. METHODS AND RESULTS: A quantitative survey was undertaken of physicians comprising multiple specialties (emergency department, n = 35; primary care, n = 35; hospitalists, n = 30; neurologists, n = 30; nonimplanting, n = 34, and implanting-cardiologists, n = 35)...
February 2018: Pacing and Clinical Electrophysiology: PACE
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