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Ca 125 endometriosis

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https://www.readbyqxmd.com/read/28545269/-risk-factors-of-endometriosis-associated-ovarian-carcinoma-in-women-aged-45-years-and-older
#1
Z X He, S Wang, Z F Li, L Zhu, J H Leng, J H Lang
Obiective: To explore the risk factors of endometriosis-associated ovarian cancer (EAOC) in women with ovarian endometriosis aged 45 years and older in China. Methods: The medical records of total 1 038 women aged 45 years and older with a surgicopathological diagnosis of ovarian endometriosis treated at Peking Union Medical College Hospital from December 1994 to December 2014 were reviewed. Histology evaluation determined ovarian endometriosis with (n=30) or without (n=1 008) ovarian cancer. Results: (1) There were 30 (2...
May 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28355687/-clinical-analysis-of-pelvic-abscess-with-endometriosis
#2
Y T Liu, H H Shi, X Yu, S Wang, Q B Fan, H Y Liu
Objective: To investigate the clinical features, diagnosis and treatments of pelvic abscess with endometriosis. Methods: A retrospective analysis was performed on 129 cases of pelvic abscess in Peking Union Medical College Hospital from January 2000 to January 2016. Among them, 34 women with endometriosis were divided into the study group and the others were in the control group. The clinical characteristics, therapeutic regimens and outcomes were compared. Results: (1) General conditions: there were no statistic differences between the two groups in age, WBC, serum CA(125), intrauterine device in use, pelvic inflammatory disease history; while incidence rates of dysmenorrhea (65%, 22/34) and infertility (21%, 7/34) in the study group were higher than those in the control group (all P<0...
March 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28271701/an-update-on-the-biological-markers-of-endometriosis
#3
Razvan Socolov, Demetra Socolov, Allia Sindilar, Ioana Pavaleanu
BACKGROUND: Endometriosis is a disease that affects 7-10% of reproductive-age women. When its diagnosis is delayed, its management becomes more difficult. Both for earlier detection and for therapeutic follow-up, discovering noninvasive biological markers with good specificity for this disease is a promising aspect of its research. We analyzed the recent data in the literature regarding these markers to determine which were worth following. MATERIALS AND METHODS: This literature review focused on medical data reported in the last 6 years (2011-2016)...
March 7, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28254227/unexpected-epithelial-ovarian-cancers-arising-from-presumed-endometrioma-a-10-year-retrospective-analysis
#4
Hsin-Hong Kuo, Chen-Ying Huang, Shir-Hwa Ueng, Kuan-Gen Huang, Chyi-Long Lee, Chih-Feng Yen
OBJECTIVE: To evaluate the incidence and prognosis of unexpected epithelial ovarian cancers (EOCs) occurring in presumed benign endometrioma. MATERIALS AND METHODS: Patients who underwent primary surgery at Chang Gung Memorial Hospital between November 2003 and October 2013 were searched with the Systematized Nomenclature of Medicine code followed by chart review. RESULTS: The incidence of unexpected EOCs in presumed ovarian endometrioma was 0...
February 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28008424/correlation-of-ca-125-serum-level-and-clinico-pathological-characteristic-of-patients-with-endometriosis
#5
Mojgan Karimi-Zarchi, Najmeh Dehshiri-Zadeh, Leili Sekhavat, Fahime Nosouhi
BACKGROUND: Cancer antigen 125 (CA-125) is a glycoprotein biomarker that is used in women with pelvic masses such as endometriosis and maybe is useful in practice of patients suspicious to endometriosis. OBJECTIVE: The aim of this study was to evaluate the association between preoperative serum CA-125 levels and clinic pathological characteristic in women with endometriosis, and find out the best serum CA-125 levels cut-off in pre and post menopause women. MATERIALS AND METHODS: Serum CA-125 levels in 87 women aged 21-54 years suspected to endometriosis with pelvic pain, dysmenorrhea, or dyspareunia were measured preoperatively...
November 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27987404/diagnostic-accuracy-of-cancer-antigen-125-ca125-for-endometriosis-in-symptomatic-women-a-multi-center-study
#6
Martin Hirsch, James M N Duffy, Christine S Deguara, Colin J Davis, Khalid S Khan
STUDY OBJECTIVE: To assess the diagnostic accuracy of serum Cancer Antigen 125 (CA 125)≥30units/milliliter (u/ml) for diagnosing endometriosis in symptomatic women. STUDY DESIGN: Prospective observational cohort study including patients with symptoms of pelvic pain or subfertility undergoing elective diagnostic laparoscopy at two tertiary referral hospitals. We excluded patients suspected to have other gynecological pathology. We evaluated the accuracy of serum CA 125 (index test) with histologically confirmed endometriosis (reference standard)...
March 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27912770/endometriosis-associated-clear-cell-carcinoma-arising-in-caesarean-section-scar-a-case-report-and-review-of-the-literature
#7
REVIEW
Gabriella Ferrandina, Eleonora Palluzzi, Francesco Fanfani, Stefano Gentileschi, Anna Lia Valentini, Maria Vittoria Mattoli, Ilaria Pennacchia, Giovanni Scambia, Gianfranco Zannoni
BACKGROUND: Malignant transformation has been reported in approximately 1% of the endometriosis cases; herein, we report a case of clear cell endometrial carcinoma arising from endometriosis foci located within a caesarean section scar. CASE PRESENTATION: In November 2014, a Caucasian, 44-year-old woman was transferred to our institution because of severe respiratory failure due to massive lung embolism and rapid enlargement of a subcutaneous suprapubic mass. Abdomino-pelvic magnetic resonance showed a 10...
December 3, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27745918/prognostic-value-of-endometriosis-in-patients-with-stage-i-ovarian-clear-cell-carcinoma-experiences-at-three-academic-institutions
#8
MULTICENTER STUDY
Huimin Bai, Dongyan Cao, Fang Yuan, Guihua Sha, Jiaxin Yang, Jie Chen, Yue Wang, Zhenyu Zhang, Keng Shen
OBJECTIVES: To investigate the prognostic value of endometriosis in patients with stage I ovarian clear cell carcinoma (OCCC). METHODS: The medical records of patients with stage I OCCC who had undergone complete staging surgery followed by systemic chemotherapy were retrospectively reviewed. RESULTS: A total of 237 women were included in this study. Univariate analysis revealed that the patients with endometriosis-associated ovarian carcinoma (EAOC) had significantly improved recurrence-free survival (RFS) and overall survival (OS) than those without EAOC (5-year RFS: 91...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27678941/endometriosis-presenting-with-massive-ascites-and-an-elevated-ca-125
#9
S Farag, L Nguyen, T Kalir, D Fishman
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27602187/evaluation-of-he4-ca-125-risk-of-ovarian-malignancy-algorithm-roma-and-risk-of-malignancy-index-rmi-in-the-preoperative-assessment-of-patients-with-adnexal-mass
#10
Khawla Al Musalhi, Manal Al Kindi, Faiza Al Aisary, Fatma Ramadhan, Thuraya Al Rawahi, Khalsa Al Hatali, Waad-Allah Mula-Abed
OBJECTIVES: To evaluate the validity and compare the performance of cancer antigen-125 (CA-125), human epididymis protein 4 (HE4), the risk of malignancy index (RMI), and the risk of ovarian malignancy algorithm (ROMA) in the diagnosis of ovarian cancer in patients with ovarian lesions discovered during their preoperative work-up investigations. METHODS: This prospective, cross-sectional study looked at patients who attended the gynecology department at the Royal Hospital, Muscat, from 1 March 2014 to 30 April 2015, for the evaluation of an ovarian lesion...
September 2016: Oman Medical Journal
https://www.readbyqxmd.com/read/27485360/panel-of-autoimmune-markers-for-noninvasive-diagnosis-of-minimal-mild-endometriosis-a-multicenter-study
#11
Rahul Gajbhiye, Trupti Bendigeri, Arun Ghuge, Kashmira Bhusane, Shahina Begum, Neeta Warty, Raj Sawant, Kedar Padte, Anil Humane, Pramathes Dasmahapatra, Anahita Chauhan, Shagufta Khan
Endometriosis, characterized by the presence of endometrial-like tissue at extrauterine sites, is a common, chronic, estrogen-dependent, inflammatory condition associated with pelvic pain, subfertility, dysmenorrhea, and dyspareunia, affecting about 10% of reproductive-age women in any population. The diagnosis of endometriosis is usually delayed on an average by 8 to 11 years leading to significant consequences in terms of disease progression. The current study was aimed to validate enzyme-linked immunosorbent assay based on the epitopes of stomatin-like protein 2, tropomodulin 3 (TMOD3), and tropomyosin 3 (TPM3) for diagnosis of minimal-mild endometriosis (revised American Fertility Society Classification (rAFS) stage I-II) and to compare the performance with the reported markers: cancer antigen (CA) 125, CA19-9, α-enolase, Serine/threonine-protein kinase (PDIK1L), and syntaxin 5...
July 8, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27405583/combination-of-the-non-invasive-tests-for-the-diagnosis-of-endometriosis
#12
REVIEW
Vicki Nisenblat, Lucy Prentice, Patrick M M Bossuyt, Cindy Farquhar, M Louise Hull, Neil Johnson
BACKGROUND: About 10% of women of reproductive age suffer from endometriosis, a costly chronic disease causing pelvic pain and subfertility. Laparoscopy is the gold standard diagnostic test for endometriosis, but is expensive and carries surgical risks. Currently, there are no non-invasive tests available in clinical practice to accurately diagnose endometriosis. This review assessed the diagnostic accuracy of combinations of different non-invasive testing modalities for endometriosis and provided a summary of all the reviews in the non-invasive tests for endometriosis series...
July 13, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27330011/endometriosis-leads-to-an-increased-trefoil-factor-3-concentration-in-the-peritoneal-cavity-but-does-not-alter-systemic-levels
#13
Diana Henze, Wolf-Dietrich Doecke, Daniela Hornung, Inoncent Agueusop, Oliver von Ahsen, Kathrin Machens, Arndt A Schmitz, Isabella Gashaw
This study analyzed whether trefoil factor 3 (TFF3) is locally elevated and correlated with common biomarkers and inflammatory processes in endometriosis. Peritoneal fluid (PF) was obtained from 50 women and serum from 124 women with or without endometriosis. Experimental endometriosis was induced in female C57BL/6 mice by syngeneic transplantation of uterine tissue to the abdominal wall. Levels of TFF3 in PF of women with endometriosis were significantly increased (P < .05) and correlated with local levels of known biomarkers for endometriosis: cancer antigen (CA) 125, CA-19-9, interleukin 8, monocyte chemotactic protein 1, and matrix metalloproteinase 7...
June 20, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27173590/diagnostic-accuracy-of-cancer-antigen-125-for%C3%A2-endometriosis-a-systematic-review-and-meta-analysis
#14
REVIEW
M Hirsch, Jmn Duffy, C J Davis, M Nieves Plana, K S Khan
BACKGROUND: The development of a non-invasive and accurate diagnostic biomarker for endometriosis is urgently needed. OBJECTIVE: Evaluate the diagnostic accuracy of serum cancer antigen 125 (CA 125) for endometriosis. SEARCH STRATEGY: We searched EMBASE, MEDLINE, and Web of Science from inception to January 2016. SELECTION CRITERIA: Diagnostic accuracy studies of serum CA 125 (index test) for histologically confirmed endometriosis (reference standard) were included...
October 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27132058/blood-biomarkers-for-the-non-invasive-diagnosis-of-endometriosis
#15
REVIEW
Vicki Nisenblat, Patrick M M Bossuyt, Rabia Shaikh, Cindy Farquhar, Vanessa Jordan, Carola S Scheffers, Ben Willem J Mol, Neil Johnson, M Louise Hull
BACKGROUND: About 10% of reproductive-aged women suffer from endometriosis, a costly chronic disease causing pelvic pain and subfertility. Laparoscopy is the gold standard diagnostic test for endometriosis, but is expensive and carries surgical risks. Currently, there are no non-invasive or minimally invasive tests available in clinical practice to accurately diagnose endometriosis. Although other reviews have assessed the ability of blood tests to diagnose endometriosis, this is the first review to use Cochrane methods, providing an update on the rapidly expanding literature in this field...
May 1, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27094925/endometrial-biomarkers-for-the-non-invasive-diagnosis-of-endometriosis
#16
REVIEW
Devashana Gupta, M Louise Hull, Ian Fraser, Laura Miller, Patrick M M Bossuyt, Neil Johnson, Vicki Nisenblat
BACKGROUND: About 10% of reproductive-aged women suffer from endometriosis, which is a costly, chronic disease that causes pelvic pain and subfertility. Laparoscopy is the gold standard diagnostic test for endometriosis, but it is expensive and carries surgical risks. Currently, there are no non-invasive tests available in clinical practice that accurately diagnose endometriosis. This is the first diagnostic test accuracy review of endometrial biomarkers for endometriosis that utilises Cochrane methodologies, providing an update on the rapidly expanding literature in this field...
April 20, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27060532/lymph-node-involvement-in-deep-infiltrating-intestinal-endometriosis-does-it-really-mean-anything
#17
Roberto Rossini, Daniela Monsellato, Luca Bertolaccini, Anna Pesci, Giuseppe Zamboni, Marcello Ceccaroni, Giacomo Ruffo
STUDY OBJECTIVE: To review our data for any correlation between the severity of endometriosis and lymph node involvement. DESIGN: Observational study with control (Canadian Task Force classification III). SETTING: Public medical center. PATIENTS: All women who underwent laparoscopic segmental rectal resection for endometriosis at our institution (Sacro Cuore Negrar Hospital) between 2000 and 2010. INTERVENTIONS: We retrospectively included 140 cases of colorectal surgery for intestinal endometriosis performed between 2004 and 2010 in our institution...
July 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/26863639/the-prognostic-value-of-pretreatment-ca-125-levels-and-ca-125-normalization-in-ovarian-clear-cell-carcinoma-a-two-academic-institute-study
#18
Huimin Bai, Guisha Sha, Meizhu Xiao, Huiqiao Gao, Dongyan Cao, Jiaxin Yang, Jie Chen, Yue Wang, Zhenyu Zhang, Keng Shen
OBJECTIVES: The present study investigated the clinical implications of pretreatment carbohydrate antigen 125 (CA-125) levels and CA-125 normalization in patients with ovarian clear cell carcinoma (CCC), and it provides useful information for the improvement of monitoring strategies for this lethal disease. METHODS: The medical records of patients with ovarian CCC who had undergone primary staging surgery or cytoreductive surgery followed by systemic chemotherapy were retrospectively reviewed...
March 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/26692541/use-of-neutrophil-to-lymphocyte-ratio-combined-with-ca-125-to-distinguish-endometriomas-from-other-benign-ovarian-cysts
#19
Aytekin Tokmak, Gulçin Yildirim, Efser Öztaş, Serra Akar, Kudret Erkenekli, Pınar Gülşen, Nafiye Yilmaz, Mustafa Uğur
PURPOSE: The objective of this study was to evaluate the diagnostic value of the neutrophil-to-lymphocyte ratio (NLR) compared to CA-125 in patients with endometriomas. METHODS: This study was designed as a retrospective comparative study. A total of 807 women who underwent surgery due to benign ovarian cysts between January 2008 and January 2013 were included in the study. The NLR and CA-125 levels were assessed separately and together, with a receiver-operating characteristic curve analysis for the diagnosis of endometriomas...
June 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/26583603/serum-prolactin-and-ca-125-levels-as-biomarkers-of-peritoneal-endometriosis
#20
LETTER
João Paolo Bilibio, João S L Cunha-Filho
No abstract text is available yet for this article.
2016: Gynecologic and Obstetric Investigation
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