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https://www.readbyqxmd.com/read/28212739/individualized-corrected-qt-interval-is-superior-to-qt-interval-corrected-using-the-bazett-formula-in-predicting-mutation-carriage-in-families-with-long-qt-syndrome
#1
Tomas Robyns, Rik Willems, Bert Vandenberk, Joris Ector, Christophe Garweg, Cuno Kuiperi, Jeroen Breckpot, Anniek Corveleyn, Stefan Janssens, Hein Heidbuchel, Dieter Nuyens
BACKGROUND: Long QT syndrome (LQTS) is characterized by reduced penetrance and variable QT prolongation over time, resulting in an estimate of 25% carriers of a pathogenic mutation with a normal corrected QT (QTc) interval on the resting electrocardiogram (ECG). OBJECTIVE: The purpose of this study was to test the hypothesis that an individualized corrected QT interval derived from 24-hour Holter data more accurately predicts carriage of a pathogenic LQTS mutation than did QT derived from a standard 12-lead ECG and corrected using the Bazett formula (QTc interval)...
March 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28211133/an-unusual-short-rp-tachycardia-what-is-the-mechanism
#2
Joshua Balog
A 68-year-old man with a history of a structurally normal heart by echocardiography, an unsuccessful ablation of a narrow complex tachycardia and frequent symptoms of palpitations presents for an electrophysiology study and ablation. Baseline 12-lead EKG demonstrated sinus rhythm without ventricular preexcitation. This article is protected by copyright. All rights reserved.
February 17, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28208140/first-diagnosis-of-atrial-fibrillation-at-the-time-of-stroke
#3
Leila H Borowsky, Susan Regan, Yuchiao Chang, Alison Ayres, Steven M Greenberg, Daniel E Singer
BACKGROUND: Atrial fibrillation (AF) is a major cause of ischemic stroke. Individuals with undiagnosed AF lack the stroke protection afforded by oral anticoagulants. We obtained a contemporary estimate of the percentage of AF patients newly diagnosed at the time of stroke. METHODS: We identified patients admitted to the Massachusetts General Hospital (MGH) from January 1, 2010 to December 31, 2013 with acute ischemic stroke and either previously or newly diagnosed AF using hospital stroke registry data and stroke and AF ICD-9 code searches of hospital databases...
February 17, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28204915/-acute-chest-pain-and-new-ecg-changes-in-pacemaker-patients-a%C3%A2-clinical-challenge
#4
Matthias Hoyme, Ralf Surber, P Christian Schulze, Dirk Prochnau
We report the case of a 82-year-old woman who was admitted to our institution with acute chest pain, nausea, and vomiting. Because of atrial fibrillation with intermittent bradycardia, a single-chamber pacemaker was implanted 4 years ago. The initial 12-lead ECG showed atrial fibrillation with a heart rate of 70 bpm, narrow QRS, and T‑wave inversions in the inferolateral leads. Coronary artery disease was excluded by immediate cardiac catheterization. A subsequent ECG three hours later showed a ventricular paced rhythm...
February 15, 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28198403/noninvasive-quantification-of-blood-potassium-concentration-from-ecg-in-hemodialysis-patients
#5
Cristiana Corsi, Marilisa Cortesi, Giulia Callisesi, Johan De Bie, Carlo Napolitano, Antonio Santoro, David Mortara, Stefano Severi
Blood potassium concentration ([K(+)]) influences the electrocardiogram (ECG), particularly T-wave morphology. We developed a new method to quantify [K(+)] from T-wave analysis and tested its clinical applicability on data from dialysis patients, in whom [K(+)] varies significantly during the therapy. To elucidate the mechanism linking [K(+)] and T-wave, we also analysed data from long QT syndrome type 2 (LQT2) patients, testing the hypothesis that our method would have underestimated [K(+)] in these patients...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28197295/spontaneous-coronary-artery-dissection-the-phantom-menace
#6
Nikolaos Spinthakis, Nada Abdulkareem, Mohamed Farag, Diana A Gorog
We present a case of a 66-year-old lady with chest pain, without dynamic 12-lead electrocardiographic (ECG) changes and normal serial troponin. Coronary angiography revealed a linear filing defect in the first obtuse marginal branch of the circumflex artery indicating coronary artery dissection, with superadded thrombus. She was managed medically with dual antiplatelet therapy and has responded well. Spontaneous coronary artery dissection (SCAD) is a rare cause of cardiac chest pain, which can be missed without coronary angiography...
December 2016: Cardiology Research
https://www.readbyqxmd.com/read/28197213/shannon-s-energy-based-algorithm-in-ecg-signal-processing
#7
Hamed Beyramienanlou, Nasser Lotfivand
Physikalisch-Technische Bundesanstalt (PTB) database is electrocardiograms (ECGs) set from healthy volunteers and patients with different heart diseases. PTB is provided for research and teaching purposes by National Metrology Institute of Germany. The analysis method of complex QRS in ECG signals for diagnosis of heart disease is extremely important. In this article, a method on Shannon energy (SE) in order to detect QRS complex in 12 leads of ECG signal is provided. At first, this algorithm computes the Shannon energy (SE) and then makes an envelope of Shannon energy (SE) by using the defined threshold...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28191332/angiotensin-ii-type-1-receptor-gene-a1166c-polymorphism-was-not-associated-with-acute-coronary-syndrome-in-an-iranian-population
#8
Navid Delshad, Majid Ghayour-Mobarhan, Hamed Mirzaei, Kamal Razavi-Azarkhiavi, Mohsen Moohebati, Mitra Hassany, Jamal Kasaian, Mohammad Reza Etemadzadeh, Maryam Sadat Alavi, Javad Behravan
BACKGROUND: There are very limited data for Iranian populations on the predisposing genetic factors for acute coronary syndrome (ACS). OBJECTIVES: The objective of the present study was to investigate the association of the angiotensin II type 1 receptor (AT1R) gene polymorphism and ACS in an Iranian population. PATIENTS AND METHODS: This cross-sectional study was conducted among 263 subjects (97 men and 166 women). Patients (n = 128) aged 30 - 80 years with chest pain were recruited from the emergency department of Ghaem Hospital (Mashhad, Iran)...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28190736/diagnosis-and-management-of-phantom-tachycardias-based-on-an-electrophysiologically-guided-approach
#9
Dimitris Tsiachris, Iosif Koutagiar, Konstantinos A Gatzoulis, Petros Arsenos, Aggeliki Rigatou, Polychronis Dilaveris, Skevos Sideris, Achilleas Papadopoulos, Alekos Kritikos, Christodoulos Stefanadis, Dimitris Tousoulis
BACKGROUND: Non-documented palpitations, or phantom tachycardias, are palpitations deemed to be of unknown origin after evaluation with conventional diagnostic tools, such as 12-lead electrocardiogram and Holter recordings. Our aim was to determine the diagnostic value of an electrophysiologic study (EPS) and its role in the management of patients presenting with non-documented palpitations. METHODS: We performed EPS in 78 consecutive patients with repeatable, poorly tolerated symptoms of paroxysmal, non-documented tachycardia, the absence of structural heart disease and at least one 24-h Holter recording...
November 20, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28187886/quantification-of-the-first-order-high-pass-filter-s-influence-on-the-automatic-measurements-of-the-electrocardiogram
#10
Jonas Isaksen, Remo Leber, Ramun Schmid, Hans-Jakob Schmid, Gianluca Generali, Roger Abächerli
BACKGROUND AND OBJECTIVE: The first-order high-pass filter (AC coupling) has previously been shown to affect the ECG for higher cut-off frequencies. We seek to find a systematic deviation in computer measurements of the electrocardiogram when the AC coupling with a 0.05 Hz first-order high-pass filter is used. METHODS: The standard 12-lead electrocardiogram from 1248 patients and the automated measurements of their DC and AC coupled version were used. We expect a large unipolar QRS-complex to produce a deviation in the opposite direction in the ST-segment...
February 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28185059/severe-proarrhythmic-potential-of-the-antiemetic-agents-ondansetron-and-domperidone
#11
Gerrit Frommeyer, Christina Fischer, Christian Ellermann, Philipp S Lange, Dirk G Dechering, Simon Kochhäuser, Michael Fehr, Lars Eckardt
The potential of ondansetron and domperidone, both clinically established antiemetic agents, to increase the QT-interval has been described in several case reports. Therefore, the aim of the present study was to investigate whether these drugs may provoke polymorphic ventricular tachycardia in a sensitive experimental model of drug-induced proarrhythmia. In 10 female rabbits, ondansetron (1, 5 and 10 µM, n = 10) or domperidone (0.5, 1 and 2 µM, n = 8) was infused after obtaining baseline data. Eight endo- and epicardial monophasic action potentials and a simultaneously recorded 12-lead ECG reproduced the clinically observed QT-prolongation (ondansetron: 1 µM:+17 ms, 5 µM:+41 ms, 10 µM:+78 ms, p < 0...
February 9, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/28183791/appearance-of-qrs-fragmentation-late-after-mustard-senning-repair-is-associated-with-adverse-outcome
#12
Frederik Helsen, Bert Vandenberk, Pieter De Meester, Alexander Van De Bruaene, Charlien Gabriels, Els Troost, Marc Gewillig, Bart Meyns, Rik Willems, Werner Budts
OBJECTIVE: To evaluate if development of fragmented QRS (fQRS) complexes, a marker of inhomogeneous ventricular activation due to myocardial fibrosis, is associated with adverse outcome in adults after Mustard/Senning repair for d-transposition of the great arteries (d-TGA). METHODS: Adults with atrial switch repair for d-TGA were selected from the database of a tertiary care hospital. Exclusion criteria were systemic right ventricular (RV) assist device or heart transplantation (HTx) before the age of 16, or fQRS already present at first visit to the Adult Congenital Heart Disease clinic...
February 9, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28183339/prevalence-and-associated-factors-of-resting-electrocardiogram-abnormalities-among-systemic-lupus-erythematosus-patients-without-cardiovascular-disease
#13
Hanan Al Rayes, Paula J Harvey, Dafna D Gladman, Jiandong Su, Arthy Sabapathy, Murray B Urowitz, Zahi Touma
BACKGROUND: Electrocardiogram (ECG) cardiovascular disease (CVD) abnormalities (ECG-CVD) are predictive of subsequent CVD events in the general population. Systemic lupus erythematosus (SLE) patients are vulnerable to CVD. We aimed to determine the prevalence of ECG-CVD in SLE patients and to examine the risk factors associated with ECG-CVD. METHODS: A 12-lead resting supine ECG was performed on consecutive adult patients attending the clinic. One cardiologist interpreted the ECGs...
February 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28181210/the-differences-in-ecgs-interpretation-in-top-level-athletes
#14
Agnieszka A Jakubiak, Krystyna Burkhard-Jagodzińska, Wojciech Król, Marcin Konopka, Dominik Bursa, Dariusz Sitkowski, Marek Kuch, Wojciech Braksator
BACKGROUND: The Ministry of Health in Poland recommends ECG- based cardiovascular screening in athletes, but so far, there is lack of guidelines on preparticipation assessment. We compared different criteria of ECG screening assessment in the group of top-level athletes. AIMS: The aims were to evaluate the prevalence of ECG changes in athletes that necessitate further cardiological work-up according to three criteria in various age groups as well as to identify factors determining the occurrence of changes related and unrelated to the training...
February 9, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28178304/atrial-fibrillation-among-patients-under-investigation-for-suspected-obstructive-sleep-apnea
#15
Tijn Hendrikx, Martin Sundqvist, Herbert Sandström, Carin Sahlin, Morteza Rohani, Faris Al-Khalili, Rolf Hörnsten, Anders Blomberg, Per Wester, Mårten Rosenqvist, Karl A Franklin
STUDY OBJECTIVES: Obstructive sleep apnea is common among patients with atrial fibrillation, but the prevalence and risk factors for atrial fibrillation among patients who are being investigated on suspicion of sleep apnea are not well known. The aim of the study was to estimate the prevalence of atrial fibrillation among patients investigated for suspected obstructive sleep apnea and to identify risk factors for atrial fibrillation among them. METHODS: The prevalence of atrial fibrillation was investigated among 201 patients referred for suspected obstructive sleep apnea...
2017: PloS One
https://www.readbyqxmd.com/read/28178156/hyperthyroidism-with-dome-and-dart-t-wave-a-case-report-a-care-compliant-article
#16
Ping Lai, Jing-Ling Yuan, Jin-Hua Xue, Yue-Qun Qiu
RATIONALE: Dome-and-dart T waves (or bifid T waves) are a rare phenomenon in the surface electrocardiogram. These wave forms are mainly observed in patients with congenital heart disease such as atrial septal defect and ventricular septal defect. And hyperthyroidism who presented with an electrocardiogram that had dome-and-dart T waves in a precordial lead is never been reported. PATIENT CONCERNS: The patient presented with continuous tachycardia, palpitations, chest tightness, and headache for 4 days, and aggravated for 1 day...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28167077/electrocardiographic-localization-of-ventricular-tachycardia-in-patients-with-structural-heart-disease
#17
REVIEW
John M Miller, Rahul Jain, Gopi Dandamudi, Thomas R Kambur
The 12-lead electrocardiogram (ECG) during ventricular tachycardia (VT) in patients with structural heart disease contains information that helps to narrow the electrophysiologist's search for target sites for ablation. Although replacement of myocardium by scar might be expected to produce variability in the spread of activation during VT, nonetheless reasonably consistent ECG patterns exist that can regionalize exit sites from VT circuits in up to 75% of cases. Most experience with this comes from patients with prior myocardial infarction, but a growing body of data exists concerning patients with nonischemic cardiomyopathies...
March 2017: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/28165431/moxifloxacin-increases-heart-rate-in-humans
#18
Jay W Mason, Thomas E Moon
(1) Background: We assessed the effect of moxifloxacin on heart rate, and reviewed the heart rate effects of other antibiotics; (2) Methods: A total of 335 normal volunteers had 12-lead electrocardiograms recorded at multiple time points before and during treatment with moxifloxacin and with placebo in seven consecutive, thorough QT studies of crossover design; (3) Results: The average baseline heart rate across the seven studies was 61.5 bpm. The heart rate after moxifloxacin dosing was analyzed at five time points shared by all seven studies (hours 1, 2, 3, 12 and 24)...
February 5, 2017: Antibiotics
https://www.readbyqxmd.com/read/28164349/applicability-of-a-novel-formula-bogossian-formula-for-evaluation-of-the-qt-interval-in-heart-failure-and-left-bundle-branch-block-due-to-right-ventricular-pacing
#19
Gerrit Frommeyer, Harilaos Bogossian, Eleni Pechlivanidou, Philipp Conzen, Christopher Gemein, Kay Weipert, Inga Helmig, Ritvan Chasan, Victoria Johnson, Lars Eckardt, Christian W Hamm, Melchior Seyfarth, Bernd Lemke, Markus Zarse, Jörn Schmitt, Damir Erkapic
BACKGROUND: The presence of left bundle branch block (LBBB) due to right ventricular pacing represents a particular challenge in properly measuring the QTc interval. In 2014 a new formula for evaluation of QT interval in patients with LBBB was reported. METHODS: 145 patients with implantable cardioverter defibrillator (ICD) were included in this prospective multicenter observational study. Inclusion criteria were: no permanent right ventricular stimulation, an intrinsic QRS interval of <120ms and reduced left ventricular function...
February 5, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28159357/reconstruction-of-an-8-lead-surface-ecg-from-two-subcutaneous-icd-vectors
#20
David G Wilson, Peter L Cronbach, D Panfilo, Saul E Greenhut, Berthold P Stegemann, John M Morgan
INTRODUCTION: Techniques exist which allow surface ECGs to be reconstructed from reduced lead sets. We aimed to reconstruct an 8-lead ECG from two independent S-ICD sensing electrodes vectors as proof of this principle. METHODS: Participants with ICDs (N=61) underwent 3minute ECGs using a TMSi Porti7 multi-channel signal recorder (TMS international, The Netherlands) with electrodes in the standard S-ICD and 12-lead positions. Participants were randomised to either a training (N=31) or validation (N=30) group...
January 27, 2017: International Journal of Cardiology
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