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https://www.readbyqxmd.com/read/28808886/assessment-of-pharmacokinetic-interactions-between-obeticholic-acid-and-caffeine-midazolam-warfarin-dextromethorphan-omeprazole-rosuvastatin-and-digoxin-in-phase-1-studies-in-healthy-subjects
#1
Jeffrey E Edwards, Lise Eliot, Andrew Parkinson, Sharon Karan, Leigh MacConell
INTRODUCTION: Obeticholic acid (OCA), a potent and selective farnesoid X receptor agonist, is indicated for the treatment of primary biliary cholangitis (PBC). We investigated the potential drug-drug interaction effect of OCA on metabolic CYP450 enzymes and drug transporters. METHODS: Five phase 1 single-center, open-label, fixed-sequence, inpatient studies were conducted in healthy adult subjects to evaluate the effect of oral daily doses of 10 or 25 mg OCA on single-dose plasma pharmacokinetics of specific probe substrates for enzymes CYP1A2 (caffeine, R-warfarin), CYP3A (midazolam, R-warfarin), CYP2C9 (S-warfarin), CYP2D6 (dextromethorphan), CYP2C19 (omeprazole), and drug transporters, BCRP/OATP1B1/OATP1B3 (rosuvastatin), and P-gp (digoxin)...
August 14, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28800177/exercise-stress-test-reveals-ineligibility-for-subcutaneous-implantable-cardioverter-defibrillator-in-patients-with-brugada-syndrome
#2
Motomi Tachibana, Nobuhiro Nishii, Hiroshi Morita, Koji Nakagawa, Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Ito
BACKGROUND: The eligibility of patients with Brugada syndrome (BrS) for implantation of a subcutaneous implantable cardioverter defibrillator (S-ICD) is not well known. This study aimed to clarify the eligibility of BrS patients for S-ICD using electrocardiography (ECG) at rest and during exercise testing. We also analyzed factors associated with ineligibility for S-ICD from standard 12-lead ECG at rest. METHODS: We enrolled 110 consecutive BrS patients who visited Okayama university hospital from December 2015 to December 2016...
August 11, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28795416/the-acute-effect-of-beta-guanidinopropionic-acid-versus-creatine-or-placebo-in-healthy-men-abc-trial-a-randomized-controlled-first-in-human-trial
#3
F A Karamat, D L Horjus, Y C Haan, L van der Woude, M C Schaap, I Oudman, G A van Montfrans, R Nieuwland, G S Salomons, J F Clark, L M Brewster
AIM: Increasing evidence indicates that the ATP-generating enzyme creatine kinase (CK) is involved in hypertension. CK rapidly regenerates ATP from creatine phosphate and ADP. Recently, we showed that beta-guanidinopropionic acid (GPA), a kidney-synthesized creatine analogue and competitive CK inhibitor, reduced blood pressure in spontaneously hypertensive rats. To further develop the substance as a potential blood pressure-lowering agent, we assessed the tolerability of a sub-therapeutic GPA dose in healthy men...
August 10, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28791852/cardiac-tumors-in-children-a-20-year-review-of-clinical-presentation-diagnostics-and-treatment
#4
Joanna Kwiatkowska, Anna Wałdoch, Jarosław Meyer-Szary, Piotr Potaż, Marek Grzybiak
BACKGROUND: The use of new imaging techniques has contributed significantly to earlier diagnosis and treatment of cardiac tumors. OBJECTIVES: The aim of the study was to analyze data from children with cardiac tumors in terms of clinical presentation, the role of noninvasive diagnostic procedures and the long-term outcome. MATERIAL AND METHODS: The data analyzed retrospectively concerned 30 children in whom cardiac tumors were diagnosed from January 1995 to July 2015...
March 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28791627/influence-of-intravenous-administration-of-the-antipsychotic-drug-benperidol-on-the-qt-interval
#5
Alexander Schmidt, Peter Fischer, Beate Wally, Joachim Scharfetter
A group effect is generally assumed regarding the prolongation of the QT interval through butyrophenone antipsychotics like haloperidol. Consequently intravenous administration of benperidol is seen critically notwithstanding sparse evidence; thus benperidol and haloperidol were compared regarding their cardiac risk of prolonging the QT interval when administered intravenously for acute sedation of psychotic patients. The QT interval was measured by a 12-lead ECG. For the correction of QT values Bazett's formula was used...
August 8, 2017: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/28790281/-perioperative-management-for-prevention-of-cardiac-complications-in-general-thoracic-surgery
#6
Terumoto Koike, Masanori Tsuchida
For general thoracic surgeons, perioperative management for prevention of cardiac complications is important because patients undergoing general thoracic surgery often have risk factors for cardiac disease. Sever cardiac failure should be detected and treated prior to surgery, and coronary artery may be examined in patients with risk factors for ischemic heart disease. Pulmonary resection sometimes causes right-sided heart failure due to reducing pulmonary vascular bed. In high-risk patients for rightsided heart failure, pulmonary artery pressure monitoring by right heart catheterization should be considered in addition to blood pressure and central venous pressure monitoring, and precise fluid management is required...
July 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28789718/cardiovascular-pre-participation-screening-in-young-athletes-recommendations-of-the-association-of-european-paediatric-cardiology
#7
Peter Fritsch, Robert Dalla Pozza, Doris Ehringer-Schetitska, Eero Jokinen, Vesna Herceg, Erzsebet Hidvegi, Renate Oberhoffer, Andreas Petropoulos
Sudden death in young competitive athletes can be avoided by implementation of pre-participation screening programmes. A screening programme should be performed only by trained physicians and should include the athlete's personal and family history, physical examination results, and the readings from a 12-lead-electrocardiogram. The athlete should undergo this screening programme every second year to detect progressive diseases. In addition, the programme should include detailed instructions to the athletes to pause training during infections in order to prevent sudden death due to myocarditis...
August 9, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28781027/tobacco-exposure-as-determined-by-serum-cotinine-and-subclinical-myocardial-injury-in-individuals-free-from-cardiovascular-disease
#8
Muhammad Ali, Yabing Li, Wesley T O'Neal, Elsayed Z Soliman
Tobacco exposure including second-hand smoke is the leading preventable cause of premature death in the United States. Serum cotinine, a highly sensitive and specific biomarker for tobacco exposure, is a more accurate measure of tobacco exposure than self-reported smoking status. Although the harmful effect of tobacco exposure on cardiovascular disease (CVD) risk factors (e.g., atherosclerosis) or hard CVD outcomes (e.g., myocardial infarction) is well established, its effect on intermediate outcomes such as subclinical myocardial injury (SMI), especially in nonsmokers, is not clear...
July 14, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28775064/ectopy-on-a-single-12-lead-ecg-incident-cardiac-myopathy-and-death-in-the-community
#9
Kaylin T Nguyen, Eric Vittinghoff, Thomas A Dewland, Jonathan W Dukes, Elsayed Z Soliman, Phyllis K Stein, John S Gottdiener, Alvaro Alonso, Lin Y Chen, Bruce M Psaty, Susan R Heckbert, Gregory M Marcus
BACKGROUND: Atrial fibrillation and heart failure are 2 of the most common diseases, yet ready means to identify individuals at risk are lacking. The 12-lead ECG is one of the most accessible tests in medicine. Our objective was to determine whether a premature atrial contraction observed on a standard 12-lead ECG would predict atrial fibrillation and mortality and whether a premature ventricular contraction would predict heart failure and mortality. METHODS AND RESULTS: We utilized the CHS (Cardiovascular Health) Study, which followed 5577 participants for a median of 12 years, as the primary cohort...
August 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28772106/frontal-plane-t-wave-axis-orientation-predicts-coronary-events-findings-from-the-moli-sani-study
#10
Licia Iacoviello, Marialaura Bonaccio, Augusto Di Castelnuovo, Simona Costanzo, Livia Rago, Amalia De Curtis, Deodato Assanelli, Fabio Badilini, Martino Vaglio, Mariarosaria Persichillo, Peter W Macfarlane, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano
BACKGROUND AND AIMS: The orientation of the frontal plane T-wave axis (T axis) is a reliable measure of ventricular repolarisation. We investigated the association between T-axis and the risk of coronary heart disease (CHD), heart failure (HF), atrial fibrillation (AF), stroke and cardiovascular (CVD) mortality. METHODS: A sample of 21,287 Moli-sani participants randomly recruited from the general adult (≥35 y) Italian population, free of CVD disease, were followed for a median of 4...
July 22, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28764236/clinical-significance-of-the-forsaken-avr-in-evaluation-of-tachyarrhythmias-a-reminder
#11
Dharmendra Jain, Pradeep Nigam, Manoj Indurkar, Riyas Chiramkara
INTRODUCTION: Mechanism of a regular, monomorphic Wide QRS Complex Tachycardia (WCT) is an important diagnostic challenge in day to day practice for the clinicians and affects further management and prognosis. Many of the WCT and Narrow Complex Tachycardia (NCT) produce certain characteristic changes in lead aVR by which we can differentiate between them. AIM: The present study was aimed to evaluate tachyarrhythmias in relation to lead aVR and to highlight the clinical significance of lead aVR, "The Neglected Lead"...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28762918/-noninvasive-electrophysiological-mapping-in-patients-with-complete-left-bundle-branch-block-and-different-modes-of-biventricular-pacing
#12
S V Zubarev, M P Chmelevsky, M A Budanova, M A Trukshina, T A Lyubimtseva, V K Lebedeva, D S Lebedev
OBJECTIVE: to investigate possibilities of noninvasive electrophysiological mapping (NEM) during biventricular (BiV) pacing and to compare the results with data of 12 lead ECG and tissue Doppler echocardiography (TDI). MATERIAL AND METHODS: The study included 25 patients with complete left bundle branch block (LBBB) and implanted cardiac resynchronization therapy (CRT) system. Twenty-two patients were CRT responders, three other patients did not demonstrate a clear effect...
May 2017: Kardiologiia
https://www.readbyqxmd.com/read/28762211/low-prevalence-of-atrial-fibrillation-in-amerindians-a-population-based-study-in-frequent-fish-consumers-living-in-rural-coastal-ecuador-the-atahualpa-project
#13
Oscar H Del Brutto, Aldo F Costa, José A Cano, Ernesto Peñaherrera, Karin J Plaza, Ernesto A Ledesma, Daniel Tettamanti, Mauricio Zambrano
BACKGROUND: Information on the burden of atrial fibrillation (AF) in rural areas of developing countries is limited. Here, we aimed to assess AF prevalence in community-dwelling older adults living in rural Ecuador. METHODS: Atahualpa residents aged ≥60 years (mean age 70.5 ± 8.1 years) underwent 24-h Holter monitoring. Participants belong to the Amerindian ethnic group. The mean height in the study population was 147.9 ± 8.9 cm. Oily fish was a major source of food (mean intake: 8 ± 4 servings/week)...
July 31, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28759086/assessment-of-myocardial-repolarisation-parameters-in-patients-with-familial-mediterranean-fever
#14
Kayihan Karaman, Metin Karayakali, Ertuğrul Erken, Ahmet Demirtaş, Mustafa Öztürk, Fatih Altunkaş, Arif Arisoy, Oğuzhan Ekrem Turan, Köksal Ceyhan, Ataç Çelik
BACKGROUND: Familial Mediterranean fever (FMF) is a chronic, recurrent auto-inflammatory disease characterised by self-terminating attacks of fever and sterile polyserositis. The main cause of death in auto-inflammatory diseases is cardiovascular events. Additionally, auto-inflammatory diseases have potential effects on the myocardial repolarisation parameters, including the T-wave peak-to-end (Tp-Te) interval, cTp-Te interval (corrected Tp-Te) and the cTp-Te/QT ratio. The aim of this study was to analyse the efficacy of myocardial repolarisation alterations in anticipation of cardiovascular risks in patients with FMF...
May 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28751014/disappearance-of-pathologic-anteroseptal-q-waves-after-reperfusion-with-percutaneous-coronary-intervention-pci-in-a-61-year-old-female-a-case-report
#15
Omar Abdel-Razek, Brendan P Parfrey, Sean P Connors
We report a case of a 61 year old female with disappearance of anteroseptal Q waves following an anterior STEMI. At presentation a 12 lead ECG revealed frank anteroseptal Q waves and T wave inversion (V1-V3). The patient underwent percutaneous coronary intervention (PCI) with drug eluting stenting to a critically stenosed left anterior descending artery. At a five month follow-up visit a 12 lead ECG demonstrated the complete resolution of anteroseptal Q waves and normal R wave progression was seen in the precordial leads...
June 8, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28751012/the-j-to-t-peak-interval-as-a-biomarker-in-drug-safety-studies-a-method-of-accuracy-assessment-applied-to-two-algorithms
#16
W Brian Chiu, Johan de Bie, David W Mortara
OBJECTIVES: To evaluate performance of J-to-T-peak (JTP) measurements of 12-lead ECGs, in a five-arm study using drugs with various levels of electrolyte channel block. METHODS: The novel evaluation method distinguishes between different aspects of measurement. "Random noise" is the variability among repeated measurements made without changing the conditions. "Context noise" is the variability of changes in context of the measurement, e.g. T-wave morphology, autonomic nervous system state...
July 12, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28743439/the-electrocardiographic-footprints-of-wenckebach-block
#17
REVIEW
Harry G Mond, Jitendra Vohra
In 1899, Karel Frederik Wenckebach described a cardiac arrhythmia with periodic dropped beats now referred to as a Wenckebach sequence. This was later shown to be due to a block in the atrioventricular node, but today, we identify Wenckebach sequences throughout the heart with most being recognised on the surface electrocardiograph as characteristic footprints. This manuscript will revisit Wenckebach atrioventricular block, the typical features of which only occur in about 15% of cases, with the remainder atypical...
July 3, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28739186/epicardial-fat-thickness-correlates-with-p-wave-duration-left-atrial-size-and-decreased-left-ventricular-systolic-function-in-morbid-obesity
#18
A Fernandes-Cardoso, M Santos-Furtado, J Grindler, L A Ferreira, J L Andrade, M A Santo
BACKGROUND AND AIM: Epicardial fat (EF) is increased in obesity and has important interactions with atrial and ventricular myocardium. Most of the evidence in this scenario can be confused by the presence of comorbidities such as hypertension, diabetes and dyslipidemia, which are very common in this population. The influence of EF on atrial remodeling and cardiac function demands further investigation on morbidly obese without these comorbidities. METHODS AND RESULTS: We prospectively recruited 20 metabolically healthy morbidly obese and 20 normo-weights controls...
June 1, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28738786/atrial-time-and-voltage-dispersion-are-both-needed-to-predict-new-onset-atrial-fibrillation-in-ischemic-stroke-patients
#19
Daniel Cortez, Maria Baturova, Arne Lindgren, Jonas Carlson, Yuri V Shubik, Bertil Olsson, Pyotr G Platonov
BACKGROUND: Atrial fibrillation (AF) is a known risk factor for ischemic stroke. Electrocardiographic predictors of AF in population studies such as the Framingham Heart Study, as well as in hypertensive patients have demonstrated a predictive value of the P-wave duration for development of AF. QRS vector magnitude has had a predictive value in ventricular arrhythmia development. We aimed to assess the value of the three-dimensional P-wave vector magnitude and its relationship to P-wave duration for prediction of new-onset AF after ischemic stroke...
July 24, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28729944/the-impact-of-multiple-sclerosis-onset-symptom-on-cardiac-repolarization
#20
Alma Mikkola, Aku Ojanen, Juha E K Hartikainen, Anne M Remes, Sakari Simula
INTRODUCTION: Multiple sclerosis is associated with prolonged cardiac repolarization but the underlying physiology has remained unknown. In this study, we compared cardiac repolarization during the relapsing-remitting multiple sclerosis (RRMS) disease course in patients with motor and sensory onset symptom. METHODS: Twenty-five RRMS patients with motor and 33 RRMS patients with sensory onset symptom having 12-lead electrocardiogram (ECG) recorded at the time of the first demyelinating event (ECG1) as well as at the later disease course (ECG2) were identified from the patient records...
July 2017: Brain and Behavior
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