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https://www.readbyqxmd.com/read/27909532/ajmaline-challenge-to-unmask-infrahisian-disease-in-patients-with-recurrent-and-unexplained-syncope-preserved-ejection-fraction-with-or-without-conduction-abnormalities-on-surface-ecg
#1
Francesco Pentimalli, Luca Bacino, Matteo Ghione, Giambattista Siri, Massimo Gazzarata, Paolo Bellotti
Background: Pharmacological challenge with class I antiarrhythmic drug is a recommended diagnostic test in patients with unexplained syncope only in the presence of bundle branch block, when non-invasive tests have failed to make the diagnosis. Its role in patients with minor or no conduction disturbances on 12-leads ECG has not been evaluated yet. It is also not clear which are the values of His-Ventricular interval to be considered diagnostic. We sought to evaluate the role of ajmaline challenge in unmasking the presence of an infrahisian disease in patients with recurrent and unexplained syncope, regardless of the existence of conduction disturbances on surface ECG...
August 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27908843/treatment-of-acute-coronary-syndrome-by-telemedically-supported-paramedics-compared-with-physician-based-treatment-a-prospective-interventional-multicenter-trial
#2
Jörg C Brokmann, Clemens Conrad, Rolf Rossaint, Sebastian Bergrath, Stefan K Beckers, Miriam Tamm, Michael Czaplik, Frederik Hirsch
BACKGROUND: Prehospital treatment of acute coronary syndrome (ACS) in German emergency medical services (EMSs) is reserved for EMS physicians due to legal issues. OBJECTIVE: The objective of this prospective, interventional, multicenter trial was to evaluate the quality of telemedically-delegated therapy and the possible complications in patients with ACS. METHODS: After approval by the ethics committee and trial registration, a one-year study phase was started in August 2012 with 5 ambulances, telemedically equipped and staffed with paramedics, in 4 German EMS districts...
December 1, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27904509/a-new-diagnostic-tool-for-masked-hypertension-impaired-sleep-quality
#3
Fatma Erdem, Ugur Cakır, Osman Yıldırım, Aytekin Alcelik, Ibrahim Donmez, Taha Can Tuman, Sabri Onur Caglar, Alim Erdem, Mehmet Yazıcı
INTRODUCTION: The aim of this study was to evaluate the relationship between masked hypertension and impaired sleep quality. Additionally, we evaluated the diagnostic role and prevalence of poor sleep quality among patients with newly diagnosed masked hypertension. MATERIAL AND METHODS: A total of 112 individuals, 72 patients with newly diagnosed masked hypertension and 40 normotensive healthy volunteers, were included in this study. All patients underwent evaluation comprising 12-lead electrocardiography, transthoracic echocardiography, 24-hour Holter ECG, and basic laboratory tests...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27898406/low-incidence-of-atrial-fibrillation-in-patients-with-transient-ischemic-attack
#4
Kenneth Bruun Pedersen, Alexander Chemnitz, Charlotte Madsen, Niels C F Sandgaard, Søren Bak, Axel Brandes
BACKGROUND: Atrial fibrillation (AF) is a major cause of stroke. Therefore, all patients with ischemic stroke or transient ischemic attack (TIA) should be examined with 12-lead electrocardiogram (ECG) and continuous monitoring to detect AF. Current guidelines recommend at least 24 h continuous ECG monitoring, which is primarily based on studies investigating patients with ischemic stroke. The aim of our study was to investigate the diagnostic yield of 12-lead ECG and Holter monitoring in patients with TIA...
November 30, 2016: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/27895693/p-wave-dispersion-on-12-lead-electrocardiography-in-adolescents-with-neurocardiogenic-syncope
#5
Dong-Hyuk Lee, Kyung-Min Lee, Jung-Min Yoon, Jae-Woo Lim, Kyung-Ok Kho, Hong-Ryang Kil, Eun-Jung Cheon
PURPOSE: Neurocardiogenic syncope (NCS) is the most frequent cause of fainting during adolescence. Inappropriate cardiovascular autonomic control may be responsible for this clinical event. The head-up tilt test has been considered a diagnostic standard, but it is cumbersome and has a high false-positive rate. We performed a study to evaluate whether P-wave dispersion (PWD) could be a useful electrocardiographic parameter of cardiac autonomic dysfunction in children with NCS. METHODS: Fifty-four patients with NCS (28 boys and 26 girls; mean age, 12...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27889554/familial-dilated-cardiomyopathy-a-multidisciplinary-entity-from-basic-screening-to-novel-circulating-biomarkers
#6
REVIEW
D de Gonzalo-Calvo, M Quezada, O Campuzano, A Perez-Serra, J Broncano, R Ayala, M Ramos, V Llorente-Cortes, S Blasco-Turrión, F J Morales, P Gonzalez, R Brugada, A Mangas, R Toro
Idiopathic dilated cardiomyopathy has become one of the most prevalent inherited cardiomyopathies over the past decades. Genetic screening of first-degree relatives has revealed that 30-50% of the cases have a familial origin. Similar to other heart diseases, familial dilated cardiomyopathy is characterized by a high genetic heterogeneity that complicates family studies. Cli'nical screening, 12-lead electrocardiogram and transthoracic echocardiogram are recommended for patients and first-degree family members...
November 8, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27889043/pr-interval-components-and-atrial-fibrillation-risk-from-the-atherosclerosis-risk-in-communities-study
#7
Justin W Smith, Wesley T O'Neal, M Benjamin Shoemaker, Lin Y Chen, Alvaro Alonso, S Patrick Whalen, Elsayed Z Soliman
Reports on the association between the PR-interval and atrial fibrillation (AF) are conflicting. We hypothesized that inconsistencies stem from that fact that the PR-interval represents a composite of several distinct components. We examined the associations of the PR-interval and its components (P-wave onset to P-wave peak duration, P-wave peak to P-wave end duration, and PR-segment) with incident AF in 14,924 participants (mean age 54 ± 5.8 years; 26% black; 55% women) from the Atherosclerosis Risk In Communities study...
November 1, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27888398/the-value-of-the-electrocardiogram-for-evaluating-prognosis-in-patients-with-idiopathic-pulmonary-arterial-hypertension
#8
Xiao-Ling Cheng, Jian-Guo He, Zhi-Hong Liu, Qing Gu, Xin-Hai Ni, Zhi-Hui Zhao, Qin Luo, Chang-Ming Xiong
BACKGROUND: Association between electrocardiography (ECG) features and right ventricular anatomy and physiology has been established. This study is aimed to identify the value of 12-lead ECG in evaluating prognosis of patients with idiopathic pulmonary arterial hypertension (IPAH). METHOD: 194 patients with newly diagnosed IPAH were included in this study. Correlations between electrocardiography variables and hemodynamics were assessed. Univariate and multivariable cox regression analysis were performed to identify ECG variables for predicting all-cause mortality in IPAH...
November 25, 2016: Lung
https://www.readbyqxmd.com/read/27883938/pretreatment-of-activated-human-cd8-t-cells-with-il-12-leads-to-enhanced-tcr-induced-signaling-and-cytokine-production
#9
Aldo Vacaflores, Samantha N Freedman, Nicole M Chapman, Jon C D Houtman
During the immune response to pathogens and autoantigens, CD8T cells are exposed to numerous inflammatory agents including the cytokine IL-12. Previous studies have focused on how IL-12 regulates T cell functions when present during or after the activation of the T cell receptor (TCR). However, recent studies suggest that prior exposure to IL-12 also alters the TCR responsiveness of murine T cells. Whether similar phenomena occur in human activated CD8T cells and the mechanisms mediating these effects remain unexplored...
November 21, 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27878421/the-role-of-the-atrial-electromechanical-delay-in-predicting-atrial-fibrillation-in-beta-thalassemia-major-patients
#10
Anna Rago, Vincenzo Russo, Andrea Antonio Papa, Carmine Ciardiello, Bruno Pannone, Maria Carolina Mayer, Giovanni Cimmino, Gerardo Nigro
BACKGROUND: Paroxysmal atrial tachyarrhythmias frequently occur in beta-thalassemia major (β-TM) patients. The aim of the current study was to evaluate the atrial electromechanical delay (AEMD) in a large β-TM population with normal cardiac function and its relationship to atrial fibrillation (AF) onset. METHODS: Eighty β-TM patients (44 men, 36 women), with a mean age of 36.2 ± 11.1 years, and 80 healthy subjects used as controls, matched for age and gender, were studied for the occurrence of AF during a 5-year follow-up, through 30-day external loop recorder (ELR) monitoring performed every 6 months...
November 22, 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/27878364/-av-reentrant-tachycardia-and-wolff-parkinson-white-syndrome-diagnosis-and-treatment
#11
Frederik Voss, Lars Eckardt, Sonia Busch, Heidi L Estner, Daniel Steven, Philipp Sommer, Christian von Bary, Hans-Ruprecht Neuberger
The AV-reentrant tachycardia (AVRT) is a supraventricular tachycardia with an incidence of 1-3/1000. The pathophysiological basis is an accessory atrioventricular pathway (AP). Patients with AVRT typically present with palpitations, an on-off characteristic, anxiety, dyspnea, and polyuria. This type of tachycardia may often be terminated by vagal maneuvers. Although the clinical presentation of AVRT is quite similar to AV-nodal reentrant tachycardias, the correct diagnosis is often facilitated by analyzing a standard 12-lead ECG at normal heart rate showing ventricular preexcitation...
November 22, 2016: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/27877210/in-vivo-antitumor-effect-of-an-hpv-specific-promoter-driving-il-12-expression-in-an-hpv-16-positive-murine-model-of-cervical-cancer
#12
Victor Hugo Bermúdez-Morales, Geny Fierros-Zarate, Celina García-Meléndrez, Juan Manuel Alcocer-Gonzalez, Ausencio Morales-Ortega, Oscar Peralta-Zaragoza, Kirvis Torres-Poveda, Ana Isabel Burguete-García, Eva Hernández-Márquez, Vicente Madrid-Marina
Human papillomavirus (HPV) is a DNA virus that infects epithelial cells and has been implicated in the development of cervical cancer. Few therapeutic strategies have been designed for the treatment of cervical intraepithelial neoplasia, a precursor of cervical cancer. In these early stages, the HPV E2 protein is the most important viral factor involved in viral gene expression and plays crucial roles during the vegetative viral cycle in epithelial cells. Papillomavirus E2 binds specifically to palindromic ACCN6GGT sequences, referred to as the E2 binding sites (E2BS), which are concentrated within the viral long control region, and which are responsible for regulation of the HPV protein's expression...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27875737/experimental-evidence-for-a-severe-proarrhythmic-potential-of-levosimendan
#13
Gerrit Frommeyer, Anja Kohnke, Christian Ellermann, Dirk G Dechering, Simon Kochhäuser, Christian Pott, Michael Fehr, Lars Eckardt
BACKGROUND: The calcium sensitizer levosimendan is established for therapy of acutely decompensated congestive heart failure. Clinical experience suggests a possible proarrhythmic potential. The aim of the present study was to assess possible proarrhythmic effects and underlying electrophysiological mechanisms. METHODS AND RESULTS: Ten rabbit hearts were isolated and Langendorff-perfused. Thereafter, levosimendan was infused in 3 concentrations (0.5, 1, and 2μM)...
November 14, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27874259/transcatheter-closure-of-calcified-patent-ductus-arteriosus-in-older-adult-patients-immediate-and-12-month-follow-up-results
#14
Xinghua Gu, Qiuwang Zhang, Hourong Sun, Jianchun Fei, Xiquan Zhang, Michael J Kutryk
OBJECTIVE: To present our experience in transcatheter closure of calcified patent ductus arteriosus (PDA) in older adult patients, which has rarely been reported. PATIENTS: From 2009 to 2014, a total of 16 patients (median age 58 years) with calcified PDA underwent transcatheter closure in our center. All patients were symptomatic with major symptoms being exertional dyspnea (in 12), palpitations (in 8), and fatigue (in 5). A continuous murmur was heard in all patients...
November 22, 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/27873284/a-case-of-acute-myocardial-infarction-due-to-cardiovascular-syphilis-with-aortic-regurgitation-and-bilateral-coronary-ostial-stenosis
#15
Mutsuo Tanaka, Minoru Okamoto, Toshihiko Murayama
We report an interesting case of a 66-year-old man with acute myocardial infarction (AMI) with bilateral coronary ostial stenosis cardiovascular syphilis complicated by aortic regurgitation (AR). A 12-lead electrocardiogram and blood tests on arrival suggested AMI, and echocardiography showed moderate AR. Emergency coronary angiography showed bilateral coronary ostial stenosis. The patient underwent emergency surgical treatment, coronary artery bypass grafting, and aortic valve replacement with a bioprosthetic valve...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27871785/hyperuricemia-is-an-independent-competing-risk-factor-for-atrial-fibrillation
#16
Masanari Kuwabara, Koichiro Niwa, Shuzo Nishihara, Yutaro Nishi, Osamu Takahashi, Kazuomi Kario, Kazuhiro Yamamoto, Takeshi Yamashita, Ichiro Hisatome
BACKGROUNDS: The relationship between serum uric acid (SUA) and atrial fibrillation (AF) remains unclear because many parameters and diseases influence AF. This study was conducted to clarify the role of hyperuricemia as an independent competing risk factor for AF in an apparently healthy general population. METHODS: We retrospectively analyzed the medical records of 90,143 Japanese subjects who underwent annual regular health check-up in St. Luke's International Hospital, Tokyo, between January 2004 and June 2010...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27867072/changes-in-electrical-dyssynchrony-by-body-surface-mapping-predict-left-ventricular-remodeling-in-cardiac-resynchronization-therapy-patients
#17
Ryan M Gage, Antonia E Curtin, Kevin V Burns, Subham Ghosh, Jeffrey M Gillberg, Alan J Bank
BACKGROUND: Electrical activation is important in CRT response. Standard ECG analysis may not accurately reflect the heterogeneity of electrical activation. OBJECTIVE: We compared changes in LV size and function following CRT to native electrical dyssynchrony and its change during pacing. METHODS: Body-surface isochronal maps utilizing 53 anterior and posterior electrodes, and 12-lead ECGs, were acquired following CRT in 66 consecutive patients...
November 17, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27862994/colchicine-increases-ventricular-vulnerability-in-an-experimental-whole-heart-model
#18
Gerrit Frommeyer, Julius Krawczyk, Dirk G Dechering, Simon Kochhäuser, Patrick Leitz, Michael Fehr, Lars Eckardt
The traditional gout medication colchicine has been reported to effectively prevent atrial fibrillation recurrence after atrial fibrillation ablation or cardiac surgery in a few clinical trials. Severe adverse events have not yet been reported. The aim of the present study was to assess possible direct electrophysiological effects in an experimental whole-heart model. Ten rabbit hearts were isolated and Langendorff-perfused. Thereafter, colchicine was administered in 2 concentrations (1μM and 3μM). Eight endo- and epicardial monophasic action potentials and a 12-lead ECG showed a stable QT interval and action potential duration during colchicine infusion...
November 11, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27855738/sexsomnia-a-specialized-non-rem-parasomnia
#19
Anne-Laure Dubessy, Smaranda Leu-Semenescu, Valérie Attali, Jean-Baptiste Maranci, Isabelle Arnulf
OBJECTIVE: To describe patients with sexsomnia and to contrast their clinical and sleep measures with those of healthy controls and sleepwalkers. METHODS: Subjects referred for sexsomnia and for sleepwalking/night terror were interviewed, completed the Paris Arousal Disorder Severity Scale (PADSS) and were monitored one to two nights with video-polysomnography. RESULTS: Seventeen patients (70.6% male, aged 17 to 76 years) had sexsomnia, with amnestic fondling of the bed partner (n=11), complete sexual intercourse (n=8), masturbation (n=8) and spontaneous orgasm (n=1)...
October 28, 2016: Sleep
https://www.readbyqxmd.com/read/27847560/left-ventricular-false-tendons-and-electrocardiogram-repolarization-abnormalities-in-healthy-young-subjects
#20
Zlatan Lazarevic, Emanuela Ciminelli, Federico Quaranta, Fabio Sperandii, Emanuele Guerra, Fabio Pigozzi, Paolo Borrione
AIM: To describe echocardiographically left ventricular false tendon characteristics and the correlation with ventricular repolarization abnormalities in young athletes. METHODS: Three hundred and sixteen healthy young athletes from different sport disciplines were evaluated from 2009 to 2011 during routine screening for agonistic sports eligibility. All subjects, as part of standard pre-participation screening medical evaluation, underwent a basal and post step test 12-lead electrocardiogram (ECG)...
October 26, 2016: World Journal of Cardiology
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