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https://www.readbyqxmd.com/read/29150411/an-epithelial-biomarker-signature-for-idiopathic-pulmonary-fibrosis-an-analysis-from-the-multicentre-profile-cohort-study
#1
Toby M Maher, Eunice Oballa, Juliet K Simpson, Joanne Porte, Anthony Habgood, William A Fahy, Aiden Flynn, Philip L Molyneaux, Rebecca Braybrooke, Hrushikesh Divyateja, Helen Parfrey, Doris Rassl, Anne-Marie Russell, Gauri Saini, Elisabetta A Renzoni, Anne-Marie Duggan, Richard Hubbard, Athol U Wells, Pauline T Lukey, Richard P Marshall, R Gisli Jenkins
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with a variable disease trajectory. The aim of this study was to assess potential biomarkers to predict outcomes for people with IPF. METHOD: PROFILE is a large prospective longitudinal cohort of treatment-naive patients with IPF. We adopted a two-stage discovery and validation design using patients from the PROFILE cohort. For the discovery analysis, we examined 106 patients and 50 age and sex matched healthy controls from Nottingham University Hospitals NHS Trust and the Royal Brompton Hospital...
November 14, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29137078/successful-treatment-of-ovarian-cancer-with-apatinib-combined-with-chemotherapy-a-case-report
#2
Mingzi Zhang, Zhongkai Tian, Yehong Sun
RATIONALE: The standard treatment for ovarian cancer is chemotherapy with 2 drugs (taxanes and platinum drugs). However, the traditional combination of the 2 drugs has many adverse effects (AEs) and the cancer cells will quickly become resistant to the drugs. Apatinib is a small-molecule antiangiogenic agent which has shown promising therapeutic effects against diverse tumor types, but it still remains unknown whether apatinib has an antitumor effect in patients with ovarian cancer. Herein, we present a successfully treated case of ovarian cancer using chemotherapy and apatinib, in order to demonstrate the effectiveness of this new combined regimen in ovarian cancer...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135568/dynamic-prediction-of-outcome-for-patients-with-ovarian-cancer-application-of-a-joint-model-for-longitudinal-cancer-antigen-125-values
#3
Yuting Cao, Yi Jiang, Xiao Lin, Jinsong Liu, Tao Lu, Wenjun Cheng, Fangrong Yan
OBJECTIVE: In clinical practice, gynecologic oncologists are interested in predicting the prognosis of patients through information from different sources. Recently, the overall survival (OS) of ovarian cancer patients has been widely and intensively researched, and a large number of risk factors have been determined, including the biomarker of cancer antigen 125 (CA-125). For newly diagnosed patients, it is critical to construct effective prognostic models to predict prognosis dynamically by combining their CA-125 values with adjusted clinical factors...
November 11, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29132874/combining-serum-microrna-and-ca-125-as-prognostic-indicators-of-preoperative-surgical-outcome-in-women-with-high-grade-serous-ovarian-cancer
#4
Jaynish S Shah, Gregory B Gard, Jean Yang, Jayne Maidens, Susan Valmadre, Patsy S Soon, Deborah J Marsh
OBJECTIVES: The most widely used approach for the clinical management of women with high-grade serous ovarian cancer (HGSOC) is surgery, followed by platinum and taxane based chemotherapy. The degree of macroscopic disease remaining at the conclusion of surgery is a key prognostic factor determining progression free and overall survival. We sought to develop a non-invasive test to assist surgeons to determine the likelihood of achieving complete surgical resection. This knowledge could be used to plan surgical approaches for optimal clinical management...
November 10, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29131471/the-toxicological-effects-of-some-avermectins-on-goat-liver-carbonic-anhydrase-enzyme
#5
Cuneyt Caglayan, İlhami Gulcin
Avermectins are used worldwide as antiparasitic drugs in the field of veterinary medicine and as agricultural pesticides and insecticides. Carbonic anhydrase (CA, E.C. 4.2.1.1) is a zinc-containing metalloenzyme that catalyzes the reversible hydration of carbon dioxide (CO2 ) to yield protons (H(+) ) and bicarbonate (HCO3(-) ). In this study, some avermectins, including abamectin, doramectin, eprinomectin, and moxidectin, were investigated for in vitro inhibitory effects on the CA enzyme purified from goat liver, which was purified (125...
November 13, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29131023/evaluation-of-serum-nidogen-2-as-a-screening-and-diagnostic-tool-for-ovarian-cancer
#6
Haitham A Torky, Ahmed Sherif, Ashraf Abo-Louz, Mohamed Ali, Ali Ahmed, Ahmad Ali
INTRODUCTION: Ovarian cancer is a relatively common occurrence with the formation of a tumour in the ovaries and is the leading cause of death in the gynecological field. Despite enormous efforts, there are no successful screening methods developed until now to decrease mortality in this regard. AIM: To evaluate nidogen-2 as a new tumour marker combined with higher sensitivity, specificity and accuracy than carbohydrate antigen (CA-125) and Doppler ultrasound to improve early diagnosis of ovarian cancer...
November 7, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29123323/enamel-resistance-to-demineralization-after-bracket-debonding-using-fluoride-varnish
#7
Ascensión Vicente, Antonio José Ortiz Ruiz, Miriam García López, Yolanda Martínez Beneyto, Luis-Alberto Bravo-González
The aim of this study was to evaluate the elemental content and morphology of enamel subjected to demineralization cycles after bracket debonding, adhesive remnant removal, and application of a fluoride varnish. 125 bovine teeth were divided into five groups (n = 25): 1) Intact enamel; 2) Intact enamel + demineralization cycles (DC); 3) Enamel after adhesive removal; 4)Enamel after adhesive removal + DC; 5) Enamel after adhesive removal + Profluorid + DC. The weight percentages of calcium (Ca), phosphorous (P) and fluoride (F) were calculated using energy dispersive X-ray spectroscopy (EDX)...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29122643/parathyroid-hormone-related-protein-concentration-in-human-serum-and-csf-correlates-with-age
#8
Mark M Kushnir, Lisa K Peterson, Frederick G Strathmann
BACKGROUND: Parathyroid Hormone-Related Protein (PTHrP) is involved in intracellular calcium (Ca) regulation, and has been demonstrated to participate in regulation of Ca in brain cells, activation of neurons, and modulation of pain. However, there are conflicting reports regarding the presence of PTHrP in CSF. DESIGN AND METHODS: PTHrP and Ca were quantified in paired CSF and serum samples using mass spectrometry-based methods. Associations between PTHrP and Ca concentrations with age, sex and concentrations of nine CSF diagnostic markers in a set of 140 paired serum and CSF patient samples were evaluated...
November 6, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29119996/reversion-of-gold-nanoparticle-aggregates-for-the-detection-of-cu-2-and-its-application-in-immunoassays
#9
Chia-Chen Chang, Chung-Han Lee, Tzu-Heng Wu, Chie-Pein Chen, Chen-Yu Chen, Chii-Wann Lin
A high concentration of copper is a hazardous element to organisms and human health. Although various strategies have been reported for the sensitive detection of copper, a facile and rapid detection of aqueous copper has seldom been addressed to date. Here, we present an easy and accessible colorimetric method to detect Cu(2+) using the redispersion of cysteamine-modified gold nanoparticles (CA-AuNPs). Initially, CA caused the aggregation of AuNPs due to the electrostatic interaction and aggregated AuNPs can be regenerated in basic medium...
November 9, 2017: Analyst
https://www.readbyqxmd.com/read/29113651/the-role-of-f18-fdg-pet-ct-in-predicting-secondary-optimal-de-bulking-in-patients-with-recurrent-ovarian-cancer
#10
Amnon Amit, Adina Hodes, Ofer Lavie, Zohar Keidar, Emad Matanes, Lior Lowenstein
BACKGROUND AND OBJECTIVES: The decision to perform secondary cytoreductive surgery for recurrent ovarian cancer is generally determined by clinical criteria. The aim of this study was to assess the predictive capability of FDG-PET/CT in identifying patients for whom secondary optimal debulking can be obtained. METHODS: We reviewed the records of all women with suspected recurrent ovarian cancer (CA-125 levels >35 U/ml and/or clinical symptoms), at two medical centers, between January 2004 and December 2013...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29107097/case-report-low-grade-astrocytoma-within-a-mature-cystic-teratoma-in-an-adolescent-patient
#11
Nicole Yoder, Asher Marks, Pei Hui, Babak Litkouhi, Julia Cron
BACKGROUND: Mature cystic teratomas are the most common ovarian neoplasm in adolescents. They are typically benign, however malignant transformation rarely occurs. We report a low-grade astrocytoma arising from a mature cystic teratoma in an adolescent patient. CASE: The patient was a 12-year-old female with an asymptomatic ovarian cyst and subsequent cystectomy. Final pathology identified a solid tumor with glial tissue within the cyst, reported as low-grade astrocytoma arising in a mature cystic teratoma...
October 26, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29102541/nonbacterial-thrombotic-endocarditis-complicated-by-cerebral-infarction-in-a-patient-with-adenomyosis-with-high-serum-ca125-level-a-case-report
#12
Kenji Uchino, Takahiro Shimizu, Heisuke Mizukami, Kenji Isahaya, Hana Ogura, Kensuke Shinohara, Yasuhiro Hasegawa
We report a case of a 48-year-old woman with multiple cerebral infarctions caused by nonbacterial thrombotic endocarditis (NBTE) because of adenomyosis with high serum carbohydrate antigen (CA)125 level. Transesophageal echocardiography (TEE) showed a vegetation, 4 mm in diameter, adjacent to the anterior leaflet of the mitral valve on day 2. Soluble CA125 level was elevated to 901 U/mL. Intravenous infusion of unfractionated heparin sodium was started. On day 35, TEE revealed reduction of the vegetation in size, 2 mm in diameter...
November 1, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29100448/carbohydrate-antigen-125-and-carcinoembryonic-antigen-in-the-differentiation-of-tuberculous-peritonitis-and-peritonitis-carcinomatosa
#13
Huan Tong, Yang Tai, Cheng Ye, Hao Wu, Lin-Hao Zhang, Jin-Hang Gao, Zhao-Ping Yan, Zhi-Yin Huang, Cheng-Wei Tang
Tumor markers could increase in both tuberculous peritonitis and peritonitis carcinomatosa, confusing the differentiation of these diseases. This study aimed to better understand the extent of elevation and diagnostic efficacies of carbohydrate antigen 125 (CA 125), carcinoembryonic antigen (CEA) and combinative use of them in tuberculous peritonitis and peritonitis carcinomatosa. Of 2998 patients reviewed, 101, 120 and 71 patients were assigned to TBP group (tuberculous peritonitis), non-OCA group (non-ovarian carcinoma-related peritonitis carcinomatosa) and OCA group (ovarian carcinoma-related peritonitis carcinomatosa), respectively...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29079264/diagnostic-and-prognostic-biomarkers-in-ovarian-cancer-and-the-potential-roles-of-cancer-stem-cells-an-updated-review
#14
REVIEW
Thingreila Muinao, Hari Prasanna Deka Boruah, Mintu Pal
Ovarian carcinomas relate to highest death rate in gynecologic malignancies as absence of symptoms shield the disease in the early stage. Current evidences have been devoted to discovering early effective screening mechanism prior to the onset of clinical symptoms. Therefore, biomarkers are the crucial tools that are capable of predicting progression, risk stratification and overall therapeutic benefit to fight against this deadly disease. Although recent studies have revealed serum protein markers, CA-125, HE4, mesothelin etc...
October 24, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29077705/effects-of-acupuncture-for-the-treatment-of-endometriosis-related-pain-a-systematic-review-and-meta-analysis
#15
Yang Xu, Wenli Zhao, Te Li, Ye Zhao, Huaien Bu, Shilin Song
BACKGROUND: Endometriosis is a multifactorial, oestrogen-dependent, inflammatory, gynaecological condition that can result in long-lasting visceral pelvic pain and infertility. Acupuncture could be an effective treatment for endometriosis and may relieve pain. Our aim in the present study was to determine the effectiveness of acupuncture as a treatment for endometriosis-related pain. METHODS: In December 2016, six databases were searched for randomised controlled trials that determined the effectiveness of acupuncture in the treatment of endometriosis-related pain...
2017: PloS One
https://www.readbyqxmd.com/read/29076692/genital-tuberculosis-mimicking-carcinoma-ovary-can-ultrasound-guided-biopsy-be-a-resolution
#16
Nosheen Akhtar, Zartaj Hayat, Fatima Nazim
Genital tuberculosis mimicking carcinoma ovary is a well-known dilemma as there is no definitive serological or imaging modality for diagnosing abdominopelvic tuberculosis. A 20-years-old unmarried girl presented with complex adnexal mass, mild ascites and CA 125 >1000. Her staging laparotomy and frozen section was planned. Laparotomy revealed miliary tuberculosis and frozen section confirmed the diagnosis of tuberculosis. Patient was started with anti-tuberculosis treatment and follow up showed resolution of cysts...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29075172/retrospective-approach-to-evaluate-interferences-in-immunoassay
#17
Jayesh Warade
BACKGROUND: Despite the increase in sensitivity and specificity of immunoassay technique over years, analytical interference remains to be major area of concern. The interfering substances are endogenous substances that are natural, polyreactive antibodies as heterophilic or auto antibodies, or human anti-animal antibodies together with other unsuspected binding proteins that are unique to the individual. Interfering substances can interfere with the reaction between analyte and reagent antibodies in immunoassay resulting in false positive or negative values...
October 2017: EJIFCC
https://www.readbyqxmd.com/read/29055648/prognostic-factors-in-patients-undergoing-primary-cytoreductive-surgery-for-figo-stage-iiic-ovarian-tubal-or-peritoneal-cancer
#18
Alpaslan Kaban, Samet Topuz, Pınar Saip, Hamdullah Sözen, Yavuz Salihoğlu
OBJECTIVE: The aim of the study is to investigate factors related to overall survival in advanced stage ovarian, tubal, or peritoneal cancer and to identify strong and weak prognostic factors. METHODS: We retrospectively reviewed 190 patients who underwent primary cytoreductive surgery between 2003 and 2013. RESULTS: Median overall survival duration was founded 58 months (95% CI 49-67). Five-year overall survival ratio was 48.5%. Presence of tumour at upper abdomen, suboptimal cytoreduction (residual >1 cm), surgery without lymphadenectomy, and presence of peritoneal ascites more than 1 L had a significantly negative effect on overall survival, but not histological grade and CA-125 level, by univariate Cox analysis...
October 18, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29050756/clinical-significance-of-serum-ca-125-ca19-9-and-cea-in-pulmonary-tuberculosis-with-and-without-type-2-diabetes
#19
Zhi-Xiang Du, Man-Man Liang, Jing Sun, Wen-Jie Wang, Yin-Hua Liu, Jiang-Hua Yang
No abstract text is available yet for this article.
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29049328/ca-19-9-and-ca-125-as-potential-predictors-of-disease-recurrence-in-resectable-lung-adenocarcinoma
#20
Sofi Isaksson, Per Jönsson, Nastaran Monsef, Hans Brunnström, Pär-Ola Bendahl, Mats Jönsson, Johan Staaf, Maria Planck
OBJECTIVES: Among patients who underwent primary surgery for non-small cell lung cancer (NSCLC), recurrent disease is frequent and cannot be accurately predicted solely from TNM stage and histopathological features. The aim of this study was to examine the association of tumor markers in pre-operative serum with recurrent disease. MATERIAL AND METHODS: Blood samples were collected prior to lung cancer surgery from 107 patients with stage I-III lung adenocarcinoma surgically treated at Lund University hospital, Lund, Sweden, between 2005 and 2011...
2017: PloS One
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