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https://www.readbyqxmd.com/read/28918145/short-communication-relationship-between-methods-for-measurement-of-serum-electrolytes-and-the-relationship-between-ionized-and-total-calcium-and-neutrophil-oxidative-burst-activity-in-early-postpartum-dairy-cows
#1
B M Leno, E M Martens, M J B Felippe, K P Zanzalari, J C Lawrence, T R Overton
The objectives of this study were to (1) compare a test for serum measurement of total Ca (tCa), Mg, and P (VetTest Chemistry Analyzer, IDEXX Laboratories Inc., Westbrook, ME) to reference methods (spectrophotometric assays on a Beckman Coulter 640e automated clinical chemistry analyzer; Beckman Coulter, Brea, CA), (2) determine the relationship between ionized Ca (iCa) and reference method tCa in the immediate postpartum period, and (3) assess the relative value of these blood Ca indices as predictors of neutrophil oxidative burst activity...
September 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28917435/measurement-of-micronuclei-and-internal-dose-in-mice-demonstrates-that-3-monochloropropane-1-2-diol-3-mcpd-has-no-genotoxic-potency-in-vivo
#2
Jenny Aasa, Margareta Törnqvist, Lilianne Abramsson-Zetterberg
In this study 3-monochloropropane-1,2-diol (3-MCPD), a compound that appears as contaminant in refined cooking oils, has been studied with regard to genotoxicity in vivo (mice) with simultaneous measurement of internal dose using state-of-the-art methodologies. Genotoxicity (chromosomal aberrations) was measured by flow cytometry with dual lasers as the frequency of micronuclei in erythrocytes in peripheral blood from BalbC mice intraperitoneally exposed to 3-MCPD (0, 50, 75, 100, 125 mg/kg). The internal doses of 3-MCPD in the mice were calculated from N-(2,3-dihydroxypropyl)-valine adducts to hemoglobin (Hb), quantified at very low levels by high-resolution mass spectrometry...
September 13, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28911827/single-site-robot-assisted-laparoscopic-staging-surgery-for-presumed-clinically-early-stage-ovarian-cancer
#3
Ji Geun Yoo, Woo Jin Kim, Keun Ho Lee
STUDY OBJECTIVE: To present the demonstration of Robotic-assisted laparoendoscopic single-site(R-LESS) staging surgery in presumed clinically early stage ovarian cancer. DESIGN: A step-by-step presentation of the procedure using video (Canadian Task Force classification III). SETTING: A university hospital. INTERVENTION: A 29-year-old woman was referred from a local clinic for an 8x6cm sized left ovarian tumor suggesting malignancy...
September 11, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28901315/serum-expression-level-of-squamous-cell-carcinoma-antigen-highly-sensitive-c-reactive-protein-and-ca-125-as-potential-biomarkers-for-recurrence-of-cervical-cancer
#4
Suyang Guo, Bo Yang, Hongli Liu, Yuzhi Li, Shengze Li, Ling Ma, Jian Liu, Wei Guo
OBJECTIVE: The aim of this study was to evaluate the serum expression levels of squamous cell carcinoma antigen (SCC-Ag), highly sensitive C-reactive protein (hs-CRP), and CA-125 as potential serum biomarkers for recurrence of cervical cancer. METHODS: Eighty-six cervical cancer patients who received radical treatment were retrospectively included in this study from February 2011 to January 2014. Of the included 86 cases, 23 were recurred within the 36 months (recurrence group [RG]) and other 63 patients did not (non-RG [NRG])...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28899828/borderline-ovarian-tumor-in-the-pediatric-and-adolescent-population-a-case-series-and-literature-review
#5
Krista J Childress, Ninad Mohan Patil, Jodi A Muscal, Jennifer E Dietrich, Rajkumar Venkatramani
STUDY OBJECTIVE: To determine the diagnosis, management, and outcome for children and adolescents with borderline ovarian tumor (BOT), To provide a review of the literature on BOT in children and adolescents. DESIGN: A retrospective cohort study of females under age 21 diagnosed with BOT between January 2001 and May 2016. SETTING: Texas Children's Hospital, Houston, Texas PARTICIPANTS: Fourteen patients (ages 12 to 18) diagnosed with BOT. MAIN OUTCOME MEASURES: Clinical presentation, pre-operative characteristics, surgical technique, cancer stage, histology, treatment, recurrence...
September 9, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28893024/diagnostic-performance-of-serum-human-epididymis-protein-4-in-endometrial-carcinoma-a-pilot-study
#6
Rupali Dewan, Abhinav Dewan, Swati Hare, Mausumi Bhardwaj, Krati Mehrotra
INTRODUCTION: Endometrial Cancer (EC) is a common female malignant disorder. To date, there are no specific tumour markers for EC that may be routinely used in clinical practice for diagnosis. AIM: To evaluate the diagnostic performance of the serum Human Epididymis protein 4 (HE4) as biomarker for EC and to determine its association with clinicopathological variables. MATERIALS AND METHODS: The study population included 60 postmenopausal women with a diagnosis of EC and 60 healthy postmenopausal female subjects (control group)...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28884894/cdp-choline-circumvents-mercury-induced-mitochondrial-damage-and-renal-dysfunction
#7
Mabel Buelna-Chontal, Martha Franco, Luz Hernández-Esquivel, Natalia Pavón, José S Rodríguez-Zavala, Francisco Correa, Ricardo Jasso, Gregorio Pichardo-Ramos, José Santamaría, Héctor González-Pacheco, Virgilia Soto, Jorge Luis Díaz-Ruíz, Edmundo Chávez
Heavy metal ions are known to produce harmful alterations on kidney function. Specifically, the accumulation of Hg(2+) in kidney tissue may induce renal failure. In this work the protective effect of CDP-choline against the deleterious effects induced by Hg(2+) on renal function were studied. CDP-choline administered ip at a dose of 125 mg/kg body weight prevented the damage induced by Hg(2+) administration at a dose of 3 mg/kg body weight. The findings indicate that CDP-choline guards mitochondria against Hg(2+) -toxicity by preserving their ability to retain matrix content, such as accumulated Ca(2+) ...
September 8, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28878035/a-simplified-regimen-compared-with-who-guidelines-decreases-antenatal-calcium-supplement-intake-for-prevention-of-preeclampsia-in-a-cluster-randomized-noninferiority-trial-in-rural-kenya
#8
Moshood O Omotayo, Katherine L Dickin, David L Pelletier, Erick O Mwanga, Jacqueline K Kung'u, Rebecca J Stoltzfus
Background: To prevent preeclampsia, the WHO recommends antenatal calcium supplementation in populations with inadequate habitual intake. The WHO recommends 1500-2000 mg Ca/d with iron-folic acid (IFA) taken separately, a complex pill-taking regimen. Objective: The objective of this study was to test the hypothesis that simpler regimens with lower daily dosages would lead to higher adherence and similar supplement intake.Methods: In the Micronutrient Initiative Calcium Supplementation study, we compared the mean daily supplement intake associated with 2 dosing regimens with the use of a parallel, cluster-randomized noninferiority trial implemented in 16 primary health care facilities in rural Kenya...
September 6, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28877539/liquid-and-vapor-phase-activity-of-artemisia-annua-essential-oil-against-pathogenic-malassezia-spp
#9
Francesca Santomauro, Rosa Donato, Gabriella Pini, Cristiana Sacco, Roberta Ascrizzi, Anna Rita Bilia
Artemisia annua essential oil has given us many encouraging results for its numerous antimicrobial properties. In this study, the essential oil, both in liquid and in vapor phases, was tested against various Malassezia species closely related to many skin disorders in humans and animals. Malassezia treatment and eradication are mainly based on old azole drugs, which are characterized by poor compliance, unpredictable clinical efficacy, emerging resistance, and several side effects. Monoterpenes (ca. 88%) represent the most abundant group of compounds in the essential oil, mainly the oxygenated derivatives (ca...
September 6, 2017: Planta Medica
https://www.readbyqxmd.com/read/28854821/assessment-of-the-cytotoxicity-and-genotoxicity-properties-of-uvaria-chamae-p-beauv-annonaceae-and-morinda-lucida-benth-rubiaceae-in-mice
#10
M O Awodiran, A O Adepiti, K F Akinwunmi
The toxicity profile of medicinal plants is an important preclinical requirement in the development of phytomedicines. The cytotoxic and genotoxic effects of the leaf of Uvaria chamae P. Beauv (Annonaceae) and stem bark of Morinda lucida Benth (Rubiaceae) were investigated in order to provide information on their safety as antimalarial plants. The methanol extract of U. chamae and ethanol (70%) extract of M. lucida were separately orally administered (125, 250, and 750 mg/kg/day) to mice for 10 consecutive days...
August 31, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28853527/-low-grade-ovarian-cancer
#11
REVIEW
Yakir Segev, Anis Kaldawy, Ron Auslender, Ofer Lavie
According to the new and reproducible grading system of the MD Anderson Cancer Center (MDACC), low grade serous cancer (LGSC) differs greatly from the commonly known high grade serous cancer (HGSC). Pathology speaking, LGSC has less mitotic index; the grade of nuclear atypia is low to intermediate. Genetically speaking, these tumors tend to show mutation in the mitogen-activated protein kinase (MAPK) pathway, mainly in the KRAS and BRAF genes, resulting in uncontrolled proliferation; however, it seems that the presence of this mutation might be related to a better prognosis compared to their absence...
August 2017: Harefuah
https://www.readbyqxmd.com/read/28845842/an-adolescent-with-an-asymptomatic-adnexal-cyst-to-worry-or-not-to-worry-medical-versus-surgical-management-options
#12
Vincenzo De Sanctis, Ashraf T Soliman, Heba Elsedfy, Nada A Soliman, Rania Elalaily, Salvatore Di Maio, Alaa Y Ahmed, Giuseppe Millimaggi
Paraovarian cysts or paratubal cysts (PTCs) arise from either the mesothelium or from paramesonephric remnants. These present as either adnexal mass or as an incidental finding. Diagnosis is usually established on ultrasound and it is important to differentiate these from ovarian cysts. Typically PCTs appear as simple cysts by ultrasound and are indistinguishable from ovarian cysts if one does not recognize the extraovarian location. Occasionally, PTCs have internal echoes due to hemorrhage. PTCs are usually asymptomatic and benign...
August 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28845013/-progress-in-preoperative-evaluation-methods-regarding-cytoreduction-in-patients-with-advanced-ovarian-cancer
#13
Jinyang Liu, Keqiang Zhang
Primary cytoreductive surgery followed by platinum-based chemotherapy represents the standard treatment for patients with advanced ovarian cancer. But some patients with advanced ovarian cancer still have suboptimal residual disease after the primary debulking surgery. Neoadjuvant chemotherapy has been suggested as an alternative strategy to achieve no residual disease. It is important to find methods to estimate the likelihood that cytoreductive surgery will leave no residual disease. A number of studies have evaluated the use of serologic markers (such as CA-125), imaging modalities (such as CT, PETCT, MRI), and laparoscopic surgery to determine which patients are ideal predictors for neoadjuvant chemotherapy...
July 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28842710/preoperative-prognostic-nutritional-index-is-a-powerful-predictor-of-prognosis-in-patients-with-stage-iii-ovarian-cancer
#14
Weiwei Zhang, Bin Ye, Weijiang Liang, Yazhou Ren
Many established inflammation- and nutrition-related factors have been investigated as potential independent prognostic factors in various cancers, including the C-reactive protein/albumin ratio (CAR), lymphocyte/monocyte ratio (LMR), modified Glasgow prognostic score (mGPS), body mass index (BMI), and prognostic nutritional index (PNI). This study was performed to estimate the prognostic value of these factors in predicting survival and platinum resistance in ovarian cancer (OC), especially according to stage...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28837575/development-of-a-tool-for-prediction-of-ovarian-cancer-in-patients-with-adnexal-masses-value-of-plasma-fibrinogen
#15
Veronika Seebacher, Stefanie Aust, David D'Andrea, Christoph Grimm, Elisabeth Reiser, Denise Tiringer, Hannah Von Mersi, Stephan Polterauer, Alexander Reinthaller, Samir Helmy-Bader
OBJECTIVE: To develop a tool for individualized risk estimation of presence of cancer in women with adnexal masses, and to assess the added value of plasma fibrinogen. STUDY DESIGN: We performed a retrospective analysis of a prospectively maintained database of 906 patients with adnexal masses who underwent cystectomy or oophorectomy. Uni- and multivariate logistic regression analyses including pre-operative plasma fibrinogen levels and established predictors were performed...
2017: PloS One
https://www.readbyqxmd.com/read/28835604/spontaneously-ruptured-paraovarian-tumor-of-borderline-malignancy-with-extremely-elevated-serum-carbohydrate-antigen-125-ca125-levels-a-comparison-of-the-imaging-and-pathological-features
#16
Akiko Kajiyama, Hiromi Edo, Chiaki Takeya, Kaneyuki Kubushiro, Toshiaki Oharaseki, Tatsuya Gomi
BACKGROUND Paraovarian cysts are common and are generally benign; however, they are frequently misdiagnosed as being of ovarian origin. Conversely, paraovarian tumors of borderline malignancy are extremely rare. Especially, no cases of spontaneous rupture have been reported, and all previous reports had normal serum carbohydrate antigen (CA) 125 level. As for imaging findings, the presence of papillary projections in the lumen of paraovarian tumors does not always indicate malignancy or benignancy, which makes the preoperative distinction difficult...
August 24, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28834599/the-value-of-macrophage-inhibitory-cytokine-1-level-in-differentiating-benign-from-malignant-solitary-pulmonary-nodules
#17
Chun Hua Xu, Jin Shan Xue, Xiu Wei Zhang, Li Ke Yu, Yong Lin
INTRODUCTION: Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-β superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis of a wide range of cancers. OBJECTIVES: The aim of this study was to explore the diagnostic value of serum MIC-1 in patients with solitary pulmonary nodules (SPNs). METHODS: Serum specimens from 158 malignant SPN patients, 110 benign SPN patients, along with 120 healthy volunteers...
August 23, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28827719/the-risk-factors-of-bone-metastases-in-patients-with-lung-cancer
#18
Yang Zhou, Qing-Fu Yu, Ai-Fen Peng, Wei-Lai Tong, Jia-Ming Liu, Zhi-Li Liu
The risk factors of bone metastasis in patients with lung cancer are still unclear. Here, a retrospective study including a series of consecutive patients who were diagnosed with lung cancer between January 2005 and November 2016 was carried out. A total of 2021 patients with lung cancer were included in this study and 23.9% of them were found to be bone metastases. For patients with bone metastases, adenocarcinoma (62.1%) was the most common pathological subtype, and rib (62.3%) was the most frequent distant metastatic site, followed by thoracic (53...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28826726/age-stratified-analysis-of-tumor-markers-and-tumor-characteristics-in-adolescents-and-young-women-with-mature-cystic-teratoma
#19
Huseyin Yesilyurt, Berna Seckin, Ayla Aktulay, Sebnem Ozyer
BACKGROUND: Serum tumor markers are widely used for the preoperative evaluation of an adnexal mass. Elevations of cancer antigen (CA) 125 and CA 19-9 have been reported in patients with mature cystic teratoma (MCT). The aim of the study is to investigate the relation of serum tumor markers with tumor characteristics in young women with MCT. METHODS: We conducted a retrospective review of 157 patients under the age of 35 who underwent laparoscopic surgery for ovarian MCT...
August 17, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28816077/in-vitro-evaluation-of-the-occlusive-properties-of-the-artventive-endoluminal-occlusion-system-occlusion-device-for-transrenal-ureteral-occlusion
#20
Daniel Kuetting, Carsten Meyer, Hans Heinz Schild, Claus Christian Pieper
PURPOSE: Current techniques for percutaneous ureteral occlusion are either technically difficult or not satisfactory because of frequent ureteral recanalization. The purpose of this in vitro study was to evaluate the occlusive properties of an "off the shelf" solution (Endoluminal Occlusion System [EOS™]; ArtVentive Medical Group, Inc., Carlsbad, CA) for transrenal ureteral occlusion. MATERIALS AND METHODS: Both 8 and 11 mm expanded polytetrafluoroethylene-covered ArtVentive EOS devices were used in 10 porcine models...
September 14, 2017: Journal of Endourology
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