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https://www.readbyqxmd.com/read/28938731/the-importance-of-genetic-parenthood-for-infertile-men-and-women
#1
S Hendriks, K Peeraer, H Bos, S Repping, E A F Dancet
STUDY QUESTION: Do men and women beginning to attend a fertility clinic prefer genetic over non-genetic parenthood? SUMMARY ANSWER: Nearly, all infertile men and women prefer genetic parenthood. WHAT IS KNOWN ALREADY: Clinicians assume that all infertile couples prefer genetic parenthood over non-genetic parenthood and, therefore, consider treatments with donor gametes an option of last resort. Previous studies of the desire for parenthood identified 30 motivations for genetic parenthood, and 51 motivations for which having a genetically related child is not strictly necessary but might be deemed required...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938253/guidelines-for-the-diagnosis-and-management-of-critical-illness-related-corticosteroid-insufficiency-circi-in-critically-ill-patients-part-i-society-of-critical-care-medicine-sccm-and-european-society-of-intensive-care-medicine-esicm-2017
#2
Djillali Annane, Stephen M Pastores, Bram Rochwerg, Wiebke Arlt, Robert A Balk, Albertus Beishuizen, Josef Briegel, Joseph Carcillo, Mirjam Christ-Crain, Mark S Cooper, Paul E Marik, Gianfranco Umberto Meduri, Keith M Olsen, Sophia C Rodgers, James A Russell, Greet Van den Berghe
OBJECTIVE: To update the 2008 consensus statements for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in adult and pediatric patients. PARTICIPANTS: A multispecialty task force of 16 international experts in critical care medicine, endocrinology, and guideline methods, all of them members of the Society of Critical Care Medicine and/or the European Society of Intensive Care Medicine. DESIGN/METHODS: The recommendations were based on the summarized evidence from the 2008 document in addition to more recent findings from an updated systematic review of relevant studies from 2008 to 2017 and were formulated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology...
September 21, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28937032/development-and-standardization-of-a-new-cognitive-assessment-test-battery-for-chinese-aphasic-patients-a-preliminary-study
#3
Ji-Bao Wu, Zhi-Hong Lyu, Xiao-Jia Liu, Hai-Peng Li, Qi Wang
BACKGROUND: Nonlinguistic cognitive impairment has become an important issue for aphasic patients, but currently there are few neuropsychological cognitive assessment tests for it. To get more information on cognitive impairment of aphasic patients, this study aimed to develop a new cognitive assessment test battery for aphasic patients, the Non-language-based Cognitive Assessment (NLCA), and evaluate its utility in Chinese-speaking patients with aphasia. METHODS: The NLCA consists of five nonverbal tests, which could assess five nonlinguistic cognitive domains such as visuospatial functions, attention test, memory, reasoning, and executive functions of aphasic patients...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28936843/-optimization-of-alcohol-precipitation-technology-of-biqiu-granules-based-on-index-components-and-pharmacodynamics
#4
Yan-Jun Zhang, Li-Li Liu, Yun Wu, Jun-Hua Hu, Xiu-Juan Chang, Wei Xiao, En-Xiang Chao
To evaluate the rationality of alcohol precipitation technology of Biqiu granule by investigating its effect on serum histamine, IgE, IL-4, IFN and TNF-α. The contents of cafferic acid and rosmarinic acid were used as the evaluation indexes, and some factors affecting index were firstly evaluated by Plackett-Burman design; then alcohol precipitation technology was further optimized by Box-Behnken design to determine the optimal alcohol precipitation conditions. The best alcohol precipitation conditions were as follows: the relative density of herb liquor was 1...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28936629/a-comparative-study-of-generic-visual-components-of-two-dimensional-versus-three-dimensional-laparoscopic-images
#5
Michael El Boghdady, Gobinath Ramakrishnan, Benjie Tang, Afshin Alijani
AIMS: There is a strong evidence to suggest that 3D imaging improves the laparoscopic task performance when compared against 2D. However, to date, no study has explained why that might be. We identified six generic visual components during laparoscopic imaging and aimed to study each component in both 2D and 3D environments for comparison. METHODS: Twenty-four consented laparoscopic novices performed specific isolated tasks in a laparoscopic Endo Trainer in 2D and 3D separately...
September 21, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28936429/clinical-pet-mri-in-neurooncology-opportunities-and-challenges-from-a-single-institution-perspective
#6
REVIEW
Lisbeth Marner, Otto M Henriksen, Michael Lundemann, Vibeke Andrée Larsen, Ian Law
PURPOSE: Magnetic resonance imaging (MRI) plays a key role in neurooncology, i.e., for diagnosis, treatment evaluation and detection of recurrence. However, standard MRI cannot always separate malignant tissue from other pathologies or treatment-induced changes. Advanced MRI techniques such as diffusion-weighted imaging, perfusion imaging and spectroscopy show promising results in discriminating malignant from benign lesions. Further, supplemental imaging with amino acid positron emission tomography (PET) has been shown to increase accuracy significantly and is used routinely at an increasing number of sites...
2017: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28935421/stimtrack-an-open-source-software-for-manual-transcranial-magnetic-stimulation-coil-positioning
#7
Emilia Ambrosini, Simona Ferrante, Mark van de Ruit, Stefano Biguzzi, Vera Colombo, Marco Monticone, Giorgio Ferriero, Alessandra Pedrocchi, Giancarlo Ferrigno, Michael J Grey
BACKGROUND: During Transcranial Magnetic Stimulation (TMS) experiments researchers often use a neuronavigation system to precisely and accurately maintain coil position and orientation. NEW METHOD: This study aimed to develop and validate an open-source software for TMS coil navigation. StimTrack uses an optical tracker and an intuitive user interface to facilitate the maintenance of position and orientation of any type of coil within and between sessions. Additionally, online access to navigation data is provided, hereby adding e...
September 18, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28935224/the-test-retest-reliability-of-three-computerized-neurocognitive-tests-used-in-the-assessment-of-sport-concussion
#8
Jacob E Resch, Mathew Schneider, C Munro Cullum
Computerized neurocognitive tests (CNTs) are widely used at all competitive levels of sport to assess sport concussion (SC). Whereas there are multiple CNTs available, little is known about how some of the most popular platforms compare. The purpose of this study was to investigate the test-retest reliability of the Automated Neuropsychological Assessment Metrics (ANAM), Concussion Vital Signs (CVS) and the Immediate Postconcussion and Cognitive Testing battery (ImPACT) using clinically relevant time points in healthy college-age participants...
September 18, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28934994/comparison-of-methods-for-estimating-contemporary-costs-an-application-to-liver-transplantation-in-the-united-kingdom
#9
Jeshika Singh, Louise Longworth
OBJECTIVES: Our study addresses the important issue of estimating treatment costs from historical data. It is a problem frequently faced by health technology assessment analysts. We compared four approaches used to estimate current costs when good quality contemporary data are not available using liver transplantation as an example. METHODS: First, the total cost estimates extracted for patients from a cohort study, conducted in the 1990s, were inflated using a published inflation multiplier...
September 22, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28934249/variability-in-objective-and-subjective-measures-affects-baseline-values-in-studies-of-patients-with-copd
#10
Wayne H Anderson, Jae Wook Ha, David J Couper, Wanda K O'Neal, R Graham Barr, Eugene R Bleecker, Elizabeth E Carretta, Christopher B Cooper, Claire M Doerschuk, M Bradley Drummond, MeiLan K Han, Nadia N Hansel, Victor Kim, Eric C Kleerup, Fernando J Martinez, Stephen I Rennard, Donald Tashkin, Prescott G Woodruff, Robert Paine, Jeffrey L Curtis, Richard E Kanner
RATIONALE: Understanding the reliability and repeatability of clinical measurements used in the diagnosis, treatment and monitoring of disease progression is of critical importance across all disciplines of clinical practice and in clinical trials to assess therapeutic efficacy and safety. OBJECTIVES: Our goal is to understand normal variability for assessing true changes in health status and to more accurately utilize this data to differentiate disease characteristics and outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28933874/wisdom-bias-and-balance-toward-a-process-sensitive-measurement-of-wisdom-related-cognition
#11
Justin P Brienza, Franki Y H Kung, Henri C Santos, D Ramona Bobocel, Igor Grossmann
Philosophers and behavioral scientists refer to wisdom as unbiased reasoning that guides one toward a balance of interests and promotes a good life. However, major instruments developed to test wisdom appear biased, and it is unclear whether they capture balance-related tendencies. We examined whether shifting from global, de-contextualized reports to state-level reports about concrete situations provides a less biased method to assess wise reasoning (e.g., intellectual humility, recognition of uncertainty and change, consideration of the broader context at hand and perspectives of others, integration of these perspectives or compromise), which may be aligned with the notion of balancing interests...
September 21, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28933862/creim-coffee-ring-effect-imaging-model-for-monitoring-protein-self-assembly-in-situ
#12
Michael Shaw, Angelo Bella, Maxim G Ryadnov
Protein self-assembly is fundamental to nanotechnology. Self-assembling structures are produced under static in vitro conditions typically forming over hours. In contrast, hydrodynamic intracellular environments employ far shorter time scales to compartmentalize highly concentrated protein solutions. Herein, we exploit the radial capillary flow within a drying sessile droplet (the coffee ring effect) to emulate dynamic native environments and monitor an archetypal protein assembly in situ using high-speed super-resolution imaging...
September 22, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28933702/the-development-and-preliminary-validity-testing-of-the-healing-progression-rate-tool
#13
Daniel L Young, Nancy Estocado, Du Feng, Joyce Black
Accurate assessment and clear documentation are important aspects of wound care; they provide a basis for appropriate patient care decisions and reimbursement. A descriptive, qualitative study was conducted to develop and provide preliminary evidence of the validity of a new tool to measure wound healing (the Healing Progression Rate [HPR]), a modified version of the Pressure Ulcer Scale for Healing (PUSH). Three (3) groups of current and future practitioners participated in the instrument development and evaluation process: 1) 3 wound care experts/authors (2 physical therapists, 1 nurse) with a minimum of 15 years of experience, 2) 6 additional wound care experts (4 nurses and 2 physical therapists) with a minimum of 10 years experience, and 3) 120 participants (77 [64...
September 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28933330/-short-term-results-of-surgical-treatment-of-patients-with-hallux-rigidus
#14
M Dygrýnová, M Uvízl, J Gallo
PURPOSE OF THE STUDY Hallux rigidus is common and degenerative arthritis of the first metatarsophalangeal joint. The aim of this study was to assess the results of cheilectomy and total joint replacement (TJR) in patients with hallux rigidus. Minimum duration of followup was 18 months. MATERIAL AND METHODS The study included fifty-nine patients who underwent surgery at our Department due to hallux rigidus between January 2013 and December 2014. Thirty-seven patients underwent cheilectomy and twenty-two patients had total joint arthroplasty using METIS®...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28933272/evaluation-of-metabolic-and-synaptic-dysfunction-hypotheses-of-alzheimer-s-disease-ad-a-meta-analysis-of-csf-markers
#15
Roni Manyevitch, Matthew Protas, Sean Scarpiello, Marisa Deliso, Brittany Bass, Anthony Nanajian, Matthew Chang, Stefani M Thompson, Neil Khoury, Rachel Gonnella, Margit Trotz, D Blaine Moore, Emily Harms, George Perry, Lucy Clunes, Angélica Ortiz, Jan O Friedrich, Ian V J Murray
BACKGROUND: Alzheimer's disease (AD) is currently incurable and a majority of investigational drugs have failed clinical trials. One explanation for this failure may be the invalidity of hypotheses focusing on amyloid to explain AD pathogenesis. Recently, hypotheses which are centered on synaptic and metabolic dysfunction are increasingly implicated in AD. OBJECTIVE: Evaluate AD hypotheses by comparing neurotransmitter and metabolite marker concentrations in normal versus AD CSF...
September 21, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28932602/serum-transthyretin-level-as-a-plausible-marker-for-diagnosis-of-child-acute-malnutrition
#16
Behailu Tsegaye, Amha Mekasha, Solomon Genet
Malnutrition is a major underlying condition for mortality in children under five years of age in developing countries, particularly in Ethiopia. The most important forms of malnutrition in Ethiopia are protein and energy deficiencies. There is no reliable laboratory method at present to assess acute malnutrition. Transthyretin is a homotetrameric serum protein with half-life of two days. The main objective of this study was to assess the estimation of serum transthyretin level as a useful diagnostic method to evaluate nutritional status of children...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/28932269/evaluation-and-performance-of-a-newly-developed-patient-reported-outcome-instrument-for-diarrhea-predominant-irritable-bowel-syndrome-in-a-clinical-study-population
#17
Leticia Delgado-Herrera, Kathryn Lasch, Bernhardt Zeiher, Anthony J Lembo, Douglas A Drossman, Benjamin Banderas, Kathleen Rosa, Christopher Lademacher, Rob Arbuckle
BACKGROUND: To evaluate the psychometric properties of the newly developed seven-item Irritable Bowel Syndrome - Diarrhea predominant (IBS-D) Daily Symptom Diary and four-item Event Log using phase II clinical trial safety and efficacy data in patients with IBS-D. This instrument measures diarrhea (stool frequency and stool consistency), abdominal pain related to IBS-D (stomach pain, abdominal pain, abdominal cramps), immediate need to have a bowel movement (immediate need and accident occurrence), bloating, pressure, gas, and incomplete evacuation...
September 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28931399/principles-practices-and-knowledge-of-clinicians-when-assessing-febrile-children-a-qualitative-study-in-kenya
#18
Anneka M Hooft, Kelsey Ripp, Bryson Ndenga, Francis Mutuku, David Vu, Kimberly Baltzell, Linnet N Masese, John Vulule, Dunstan Mukoko, A Desiree LaBeaud
BACKGROUND: Clinicians in low resource settings in malaria endemic regions face many challenges in diagnosing and treating febrile illnesses in children. Given the change in WHO guidelines in 2010 that recommend malaria testing prior to treatment, clinicians are now required to expand the differential when malaria testing is negative. Prior studies have indicated that resource availability, need for additional training in differentiating non-malarial illnesses, and lack of understanding within the community of when to seek care play a role in effective diagnosis and treatment...
September 20, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28931345/preliminary-validation-of-the-claudication-symptom-instrument-csi
#19
Todd C Edwards, Danielle C Lavallee, Alexander W Clowes, Emily B Devine, David R Flum, Mark H Meissner, Ellen T Thomason, Skye P Barbic, Sara J Beck, Donald L Patrick
This article describes the development of the Claudication Symptom Instrument (CSI) and its measurement properties for evaluating the symptom experience of patients diagnosed with intermittent claudication (IC). We conducted semi-structured qualitative interviews with IC patients for item development and cognitive interviews in which patient comprehension of items was tested. We evaluated measurement properties using data collected and analyzed in the context of an observational comparative effectiveness study of IC treatments...
September 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28931086/re-evaluation-of-the-interrelationships-among-the-behavioral-tests-in-rats-exposed-to-chronic-unpredictable-mild-stress
#20
Congli Hu, Ying Luo, Hong Wang, Shengnan Kuang, Guojuan Liang, Yang Yang, Shaoshan Mai, Junqing Yang
The chronic unpredictable mild stress model of depression has been widely used as an experimental tool to investigate human psychopathology. Our objective was to provide an update on the validity and reliability of the chronic unpredictable mild stress model, by analyzing the interrelationships among the indexes using stepwise discriminant analysis and Pearson correlation coefficient to examine the possible combinations. We evaluated the depressive rats in both the presence and the absence of chronic unpredictable mild stress, using weight change, percentage of sucrose preference, coat state, splash test, open-field test, elevated plus-maze test, forced swimming test, and Morris water maze test...
2017: PloS One
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