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https://www.readbyqxmd.com/read/28531951/identifying-and-quantifying-geochemical-and-mixing-processes-in-the-matanza-riachuelo-aquifer-system-argentina
#1
S Armengol, M Manzano, S A Bea, S Martínez
The Matanza-Riachuelo River Basin, in the Northeast of the Buenos Aires Province, is one of the most industrialized and populated region in Argentina and it is worldwide known for its alarming environmental degradation. In order to prevent further damages, the aquifer system, which consists of two overlaid aquifers, is being monitored from 2008 by the river basin authority, Autoridad de la Cuenca Matanza-Riachuelo. The groundwater chemical baseline has been established in a previous paper (Zabala et al., 2016), and this one is devoted to the identification of the main physical and hydrogeochemical processes that control groundwater chemistry and its areal distribution...
May 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28531892/emery-dreifuss-muscular-dystrophy-associated-mutant-forms-of-lamin-a-recruit-the-stress-responsive-protein-ankrd2-into-the-nucleus-affecting-the-cellular-response-to-oxidative-stress
#2
Silvia Angori, Cristina Capanni, Georgine Faulkner, Camilla Bean, Giuseppe Boriani, Giovanna Lattanzi, Vittoria Cenni
BACKGROUND: Ankrd2 is a stress responsive protein mainly expressed in muscle cells. Upon the application of oxidative stress, Ankrd2 translocates into the nucleus where it regulates the activity of genes involved in cellular response to stress. Emery-Dreifuss Muscular Dystrophy 2 (EDMD2) is a muscular disorder caused by mutations of the gene encoding lamin A, LMNA. As well as many phenotypic abnormalities, EDMD2 muscle cells also feature a permanent basal stress state, the underlying molecular mechanisms of which are currently unclear...
May 25, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28531810/a-novel-scheme-for-the-validation-of-an-automated-classification-method-for-epileptic-spikes-by-comparison-with-multiple-observers
#3
Niraj K Sharma, Carlos Pedreira, Maria Centeno, Umair J Chaudhary, Tim Wehner, Lucas G S França, Tinonkorn Yadee, Teresa Murta, Marco Leite, Sjoerd B Vos, Sebastien Ourselin, Beate Diehl, Louis Lemieux
OBJECTIVE: To validate the application of an automated neuronal spike classification algorithm, Wave_clus (WC), on interictal epileptiform discharges (IED) obtained from human intracranial EEG (icEEG) data. METHOD: Five 10-min segments of icEEG recorded in 5 patients were used. WC and three expert EEG reviewers independently classified one hundred IED events into IED classes or non-IEDs. First, we determined whether WC-human agreement variability falls within inter-reviewer agreement variability by calculating the variation of information for each classifier pair and quantifying the overlap between all WC-reviewer and all reviewer-reviewer pairs...
May 4, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28531778/validity-assessment-of-the-nutrition-screening-initiative-checklist-in-older-adults
#4
Luna Strieder Vieira, Maria Cecília Formoso Assunção, Antônio Augusto Schäfer, Iná da Silva Dos Santos
OBJECTIVE: To ascertain whether the NSI (Nutrition Screening Initiative Checklist) is a valid screening instrument for diagnosing nutritional risk in an older population from a medium-size city in the south of Brazil. METHODS: The study population comprised individuals aged 60 years or older selected from a population-based cross-sectional survey. Data collection was carried out at two different timepoints: first, the NSI (instrument under test) was applied and later a dietary recall (gold standard) based on the previous day...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531454/preliminary-validation-of-the-malay-yale-food-addiction-scale-factor-structure-and-item-analysis-in-an-obese-population
#5
Yogarabindranath Swarna Nantha, Norafidza Ashiquin Abd Patah, Mahalakshmi Ponnusamy Pillai
BACKGROUND AND AIMS: Researchers suggest that the rise in obesity rates may be explained by the addictive properties of certain types of food. In view of the growing obesity epidemic in South-East Asia, there is a need for a psychometric tool to assess the concept of food addiction amongst high-risk populations. The objective of this study is to translate the Yale Food Addiction Scale (YFAS) into the Malay language and subsequently validate its use in an obese population. METHODS: Between the year 2014 and 2015, a total of 250 obese adults were assessed for food addiction utilizing the Malay version of the YFAS at a primary care clinic...
December 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531396/translation-and-adaptation-of-the-nutric-score-to-identify-critically-ill-patients-who-benefit-the-most-from-nutrition-therapy
#6
Mariane Rosa, Daren K Heyland, Daieni Fernandes, Estela I Rabito, Manoela L Oliveira, Aline Marcadenti
INTRODUCTION AND OBJECTIVES: Due to the scarcity of tools to assess the nutritional risk in critically ill patients, the NUTrition Risk in the Critically ill Score (NUTRIC Score) was developed and validated primarily in a limited population to quantify the risk of adverse events that may be modified by aggressive nutrition therapy. The objective of this study was to translate and adapt the NUTRIC Score into Portuguese language for further demonstrate its feasibility and clinical utility in Brazilian Intensive Care Units (ICUs)...
August 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531380/are-traditional-body-fat-equations-and-anthropometry-valid-to-estimate-body-fat-in-children-and-adolescents-living-with-hiv
#7
Luiz Rodrigo Augustemak de Lima, Priscila Custódio Martins, Carlos Alencar Souza Alves Junior, João Antônio Chula de Castro, Diego Augusto Santos Silva, Edio Luiz Petroski
The aim of this study was to assess the validity of traditional anthropometric equations and to develop predictive equations of total body and trunk fat for children and adolescents living with HIV based on anthropometric measurements. Forty-eight children and adolescents of both sexes (24 boys) aged 7-17 years, living in Santa Catarina, Brazil, participated in the study. Dual-energy X-ray absorptiometry was used as the reference method to evaluate total body and trunk fat. Height, body weight, circumferences and triceps, subscapular, abdominal and calf skinfolds were measured...
May 19, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28531373/identification-of-potential-inhibitors-for-hcv-ns3-genotype-4a-by-combining-protein-ligand-interaction-fingerprint-3d-pharmacophore-docking-and-dynamic-simulation
#8
Mahmoud Abd El-Monem El-Hasab, Eman Esmat El-Bastawissy, Tarek Faathy El-Moselhy
HCV NS3 protease domain has been one of the most attractive targets for developing new drugs for HCV infection and many drugs were successfully developed, but all of them were designed for targeting HCV genotype 1 infection. HCV genotype 4a dominant in Egypt has paid less attention. Here we describe our protocol of virtual screening in identification of novel potential potent inhibitors for HCV NS3 of genotype 4a using homology modelling, PLIF (protein ligand interaction fingerprint), docking, pharmacophore and dynamic simulation...
May 20, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28531226/intercenter-validation-of-a-knowledge-based-model-for-automated-planning-of-volumetric-modulated-arc-therapy-for-prostate-cancer-the-experience-of-the-german-rapidplan-consortium
#9
Carolin Schubert, Oliver Waletzko, Christian Weiss, Dirk Voelzke, Sevda Toperim, Arnd Roeser, Silvia Puccini, Marc Piroth, Christian Mehrens, Jan-Dirk Kueter, Kirsten Hierholz, Karsten Gerull, Antonella Fogliata, Andreas Block, Luca Cozzi
PURPOSE: To evaluate the performance of a model-based optimisation process for volumetric modulated arc therapy applied to prostate cancer in a multicentric cooperative group. The RapidPlan (RP) knowledge-based engine was tested for the planning of Volumetric modulated arc therapy with RapidArc on prostate cancer patients. The study was conducted in the frame of the German RapidPlan Consortium (GRC). METHODS AND MATERIALS: 43 patients from one institute of the GRC were used to build and train a RP model...
2017: PloS One
https://www.readbyqxmd.com/read/28531171/no-relevant-association-of-kinematic-gait-parameters-with-health-related-quality-of-life-in-parkinson-s-disease
#10
Kristina Bettecken, Felix Bernhard, Jennifer Sartor, Markus A Hobert, Marc Hofmann, Till Gladow, Janet M T van Uem, Inga Liepelt-Scarfone, Walter Maetzler
BACKGROUND: Health-related Quality of Life (HrQoL) is probably the most important outcome parameter for the evaluation and management of chronic diseases. As this parameter is subjective and prone to bias, there is an urgent need to identify objective surrogate markers. Gait velocity has been shown to be associated with HrQoL in numerous chronic diseases, such as Parkinson's disease (PD). With the development and wide availability of simple-to-use wearable sensors and sophisticated gait algorithms, kinematic gait parameters may soon be implemented in clinical routine management...
2017: PloS One
https://www.readbyqxmd.com/read/28531151/an-ensemble-spatiotemporal-model-for-predicting-pm2-5-concentrations
#11
Lianfa Li, Jiehao Zhang, Wenyang Qiu, Jinfeng Wang, Ying Fang
Although fine particulate matter with a diameter of <2.5 μm (PM2.5) has a greater negative impact on human health than particulate matter with a diameter of <10 μm (PM10), measurements of PM2.5 have only recently been performed, and the spatial coverage of these measurements is limited. Comprehensively assessing PM2.5 pollution levels and the cumulative health effects is difficult because PM2.5 monitoring data for prior time periods and certain regions are not available. In this paper, we propose a promising approach for robustly predicting PM2...
May 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28531129/rapid-and-cost-effective-quantification-of-glucosinolates-and-total-phenolic-content-in-rocket-leaves-by-visible-near-infrared-spectroscopy
#12
Eva María Toledo-Martín, Rafael Font, Sara Obregón-Cano, Antonio De Haro-Bailón, Myriam Villatoro-Pulido, Mercedes Del Río-Celestino
The potential of visible-near infrared spectroscopy to predict glucosinolates and total phenolic content in rocket (Eruca vesicaria) leaves has been evaluated. Accessions of the E. vesicaria species were scanned by NIRS as ground leaf, and their reference values regressed against different spectral transformations by modified partial least squares (MPLS) regression. The coefficients of determination in the external validation (R²VAL) for the different quality components analyzed in rocket ranged from 0.59 to 0...
May 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28531106/fully-polymeric-ph-sensor-realized-by-means-of-a-single-step-soft-embossing-technique
#13
Paola Fanzio, Chi-Tung Chang, Maciej Skolimowski, Simone Tanzi, Luigi Sasso
We present here an electrochemical sensor microsystem for the monitoring of pH. The all-polymeric device is comprised of a cyclic olefin copolymer substrate, a 200 nm-thin patterned layer of conductive polymer (PEDOT), and a 70 nm electropolymerized layer of a pH sensitive conductive polymer (polyaniline). The patterning of the fluidic (microfluidic channels) and conductive (wiring and electrodes) functional elements was achieved with a single soft PDMS mold via a single embossing step process. A post-processing treatment with ethylene glycol assured the functional enhancement of the electrodes, as demonstrated via an electrical and electrochemical characterization...
May 20, 2017: Sensors
https://www.readbyqxmd.com/read/28530582/proton-transfer-reaction-mass-spectrometry-ptr-ms-for-the-authentication-of-regionally-unique-south-african-lamb
#14
Sara W Erasmus, Magdalena Muller, Martin Alewijn, Alex H Koot, Saskia M van Ruth, Louwrens C Hoffman
The volatile fingerprints of South African lamb meat and fat were measured by proton-transfer mass spectrometry (PTR-MS) to evaluate it as an authentication tool. Meat and fat of the Longissimus lumborum (LL) of lambs from six different regions were assessed. Analysis showed that the volatile fingerprints were affected by the origin of the meat. The classification of the origin of the lamb was achieved by examining the calculated and recorded fingerprints in combination with chemometrics. Four different partial least squares discriminant analysis (PLS-DA) models were fitted to the data to classify lamb meat and fat samples into "region of origin" (six different regions) and "origin" (Karoo vs...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28530564/a-new-method-for-the-rapid-detection-of-atlantic-cod-gadus-morhua-pacific-cod-gadus-macrocephalus-alaska-pollock-gadus-chalcogrammus-and-ling-molva-molva-using-a-lateral-flow-dipstick-assay
#15
Ledicia Taboada, Ana Sánchez, Ricardo I Pérez-Martín, Carmen G Sotelo
Species-specific lateral flow dipstick (LFD) assays for the identification of Atlantic cod (Gadus morhua), Pacific cod (Gadus macrocephalus), Alaska pollock (Gadus chalcogrammus) and ling (Molva molva) in food products were developed. The method comprises a PCR system with four sets of specific primers, for each target species. This step was also devised to dual-labeling of PCR products with biotin and 6-FAM, which are then easily read on a lateral flow dipstick, upon which these products are immobilized by a fixed biotin-ligand and visualized with anti-FAM antibody-coated gold nanoparticles...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28530562/optimization-and-validation-of-a-rapid-liquid-chromatography-method-for-determination-of-the-main-polyphenolic-compounds-in-table-olives-and-in-olive-paste
#16
M Cabrera-Bañegil, T Schaide, R Manzano, J Delgado-Adámez, I Durán-Merás, D Martín-Vertedor
A high performance liquid chromatography method, coupled to diode-array and fluorescence detectors, with a previous solid-liquid extraction, has been developed for the simultaneous detection and quantification of polyphenolic compounds in table olives and in olive paste. The effects of extraction variables have been studied by response surface methodology. The best conditions were extraction with 100% methanol (2mM NaF) during 30min for table olives, and 91% methanol (2mM NaF) during 40min for olive paste. Chromatographic separation of 26 polyphenols from different families was optimized...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28530507/the-reliability-and-sensitivity-of-performance-measures-in-a-novel-pace-bowling-test
#17
Simon A Feros, Warren B Young, Brendan J O'Brien
OBJECTIVES: Evaluate the reliability and sensitivity of performance measures in a novel pace bowling test. METHODS: Thirteen male amateur club fast bowlers completed a novel pace bowling test on two separate occasions, 4-7 days apart. Participants delivered 48 balls (8 overs), at five targets on a suspended sheet, situated behind a 'live' batter who stood in a right-handed and left-handed stance for an equal amount of deliveries. Delivery instruction was frequently changed, with all deliveries executed in a pre-planned sequence...
May 22, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28530476/time-trials-versus-time-to-exhaustion-tests-effects-on-critical-power-w-and-oxygen-uptake-kinetics
#18
Bettina Karsten, Jonathan Baker, Fernando Naclerio, Andreas Klose, Antonino Bianco, Alfred Nimmerichter
PURPOSE: To investigate single-day time-to-exhaustion (TTE) and time trial (TT) based laboratory tests values of critical power (CP), Wprime (W') and respective oxygen kinetics responses. METHODS: Twelve cyclists performed a maximal ramp test followed by three TTE and three TT efforts interspersed by a 60-min recovery between efforts. Oxygen uptake was measured during all trials. The mean response time (MRT) was calculated as a description of the overall V̇O2 kinetic response from the onset to 2 min of exercise...
May 22, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28530416/assessment-centers-versus-cognitive-ability-tests-challenging-the-conventional-wisdom-on-criterion-related-validity
#19
Paul R Sackett, Oren R Shewach, Heidi N Keiser
Separate meta-analyses of the cognitive ability and assessment center (AC) literatures report higher criterion-related validity for cognitive ability tests in predicting job performance. We instead focus on 17 samples in which both AC and ability scores are obtained for the same examinees and used to predict the same criterion. Thus, we control for differences in job type and in criteria that may have affected prior conclusions. In contrast to Schmidt and Hunter's (1998) meta-analysis, reporting mean validity of ...
May 22, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28530158/analyzing-circle-of-willis-blood-flow-in-ischemic-stroke-patients-through-3d-stroke-arterial-flow-estimation
#20
Aichi Chien, Fernando Viñuela
Background The objective of ischemic stroke (IS) treatment is to achieve revascularization in cerebral arteries to restore blood flow. However, there is no available method to extract arterial flow data from clinical CTA images. We developed 3D Stroke Arterial Flow Estimation (SAFE), which provides blood flow data throughout the Circle of Willis based on 3D CTA and allows comparison of arterial flow distribution in the brain. Methods We implemented a newly developed 3D vascular reconstruction algorithm for clinical stroke CTA images...
January 1, 2017: Interventional Neuroradiology
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