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https://www.readbyqxmd.com/read/28728056/sequence-based-diversity-of-23-autosomal-str-loci-in-koreans-investigated-using-an-in-house-massively-parallel-sequencing-panel
#1
Eun Hye Kim, Hwan Young Lee, So Yeun Kwon, Eun Young Lee, Woo Ick Yang, Kyoung-Jin Shin
As DNA databases continue to grow and international cooperation increases, forensic STR loci have expanded to increase the discriminatory power and inter-database compatibility. Current capillary electrophoresis (CE) and/or massively parallel sequencing (MPS)-based commercial STR analysis systems reflect such changing trends of expanding STR loci. Due to the general gains of larger multiplexing and the detection of sequence variation, the application of MPS technology to STR analysis has further improved discrimination and is expected to aid in mixture interpretation by increasing the effective number of alleles...
July 9, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28727961/psychology-s-replication-crisis-and-the-grant-culture-righting-the-ship
#2
Scott O Lilienfeld
The past several years have been a time for soul searching in psychology, as we have gradually come to grips with the reality that some of our cherished findings are less robust than we had assumed. Nevertheless, the replication crisis highlights the operation of psychological science at its best, as it reflects our growing humility. At the same time, institutional variables, especially the growing emphasis on external funding as an expectation or de facto requirement for faculty tenure and promotion, pose largely unappreciated hazards for psychological science, including (a) incentives for engaging in questionable research practices, (b) a single-minded focus on programmatic research, (c) intellectual hyperspecialization, (d) disincentives for conducting direct replications, (e) stifling of creativity and intellectual risk taking, (f) researchers promising more than they can deliver, and (g) diminished time for thinking deeply...
July 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28727700/therapeutic-role-of-placebo-evolution-of-a-new-paradigm-in-understanding-research-and-clinical-practice
#3
Laxmaiah Manchikanti, Mark V Boswell, Alan D Kaye, Standiford Helm Ii, Joshua A Hirsch
Research into interventional techniques in managing chronic spinal pain continues to be challenging, mystifying, confusing, and biased. Insight, or lack thereof, into placebo and nocebo phenomena contributes mightily to these difficulties. Unfortunately, placebo-nocebo responses are the subject of numerous controversies and challenges from not only a research perspective, but also clinical perspective. While interventionalists consider the biggest threat to interventional pain management research is inappropriate and outdated interpretation of the data, a greater problem is the misuse of the placebo response in research, with the declaration that all and everything as a placebo effect: with a misinterpretation of the nature of the placebo the, associated conclusions can be inaccurate...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28727567/intuitionistic-multiplicative-group-analytic-hierarchy-process-and-its-use-in-multicriteria-group-decision-making
#4
Zhiming Zhang, Witold Pedrycz
As an extension of multiplicative preference relations (MPRs), intuitionistic MPRs (IMPRs) reflect experts' hesitant quantitative judgments. This paper presents an intuitionistic multiplicative preference information-based group analytic hierarchy process (AHP) and develops an intuitionistic multiplicative group AHP (IMGAHP), which addresses multicriteria group decision-making (MCGDM) that uses IMPRs to capture experts' preference judgments. First, we introduce a consistency index to gauge the consistency of IMPRs and describe the concept of acceptably consistent IMPRs...
July 17, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28725573/determination-of-nitrogen-balance-in-agroecosystems
#5
Upendra M Sainju
Nitrogen balance in agroecosystems provides a quantitative framework of N inputs and outputs and retention in the soil that examines the sustainability of agricultural productivity and soil and environmental quality. Nitrogen inputs include N additions from manures and fertilizers, atmospheric depositions including wet and dry depositions, irrigation water, and biological N fixation. Nitrogen outputs include N removal in crop grain and biomass and N losses through leaching, denitrification, volatilization, surface runoff, erosion, gas emissions, and plant senescence...
2017: MethodsX
https://www.readbyqxmd.com/read/28725286/responsibility-without-blame-for-addiction
#6
Hanna Pickard
Drug use and drug addiction are severely stigmatised around the world. Marc Lewis does not frame his learning model of addiction as a choice model out of concern that to do so further encourages stigma and blame. Yet the evidence in support of a choice model is increasingly strong as well as consonant with core elements of his learning model. I offer a responsibility without blame framework that derives from reflection on forms of clinical practice that support change and recovery in patients who cause harm to themselves and others...
2017: Neuroethics
https://www.readbyqxmd.com/read/28725095/with-whom-do-researchers-collaborate-and-why
#7
Hajdeja Iglič, Patrick Doreian, Luka Kronegger, Anuška Ferligoj
Although research collaboration has been studied extensively, we still lack understanding regarding the factors stimulating researchers to collaborate with different kinds of research partners including members of the same research center or group, researchers from the same organization, researchers from other academic and non-academic organizations as well as international partners. Here, we provide an explanation of the emergence of diverse collaborative ties. The theoretical framework used for understanding research collaboration couples scientific and technical human capital embodied in the individual with the social organization and cognitive characteristics of the research field...
2017: Scientometrics
https://www.readbyqxmd.com/read/28724513/development-of-a-tailored-hiv-prevention-intervention-for-single-young-men-who-have-sex-with-men-who-meet-partners-online-protocol-for-the-mydex-project
#8
Jose Arturo Bauermeister, Ryan C Tingler, Michele Demers, Gary W Harper
BACKGROUND: New cases of human immunodeficiency virus (HIV) among young men who have sex with men (YMSM), aged 18 to 24, underscore the importance of developmentally-informed HIV programs for YMSM. We developed an online intervention focused on risk reduction strategies across different sexual partner types. Intervention activities focus on assisting YMSM reflect on their partner-seeking behaviors, develop sexual decision-making rules to reduce their HIV risks, and consider the adoption of HIV prevention behaviors...
July 19, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28724154/mapping-residency-global-health-experiences-to-the-acgme-family-medicine-milestones
#9
Maureen O Grissom, Tochi Iroku-Malize, Rita Peila, Marco Perez, Neubert Philippe
BACKGROUND AND OBJECTIVES: Global health (GH) experiences are a unique part of family medicine (FM) training that offer an opportunity for residents to demonstrate development across a multitude of the milestones recently implemented by the Accreditation Council for Graduate Medical Education (ACGME). The GH experience presents an opportunity for resident development, and including a component of written reflection can provide tangible evidence of development in areas that can be difficult to assess...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28723956/psychosis-risk-research-versus-daily-prognosis-uncertainties-a-qualitative-study-of-french-youth-psychiatrists-attitudes-toward-predictive-practices
#10
Laelia Benoit, Marie Rose Moro, Bruno Falissard, Nicolas Henckes
BACKGROUND: Over the last twenty years, predicting psychosis has become a priority of both research and policies. Those approaches include the use of the At Risk Mental State category (ARMS) and of standardized predictive tools. In comparison to most developed countries, early interventions programs are only little developed in France. However, cases of young patients presenting unclear symptoms that might be a beginning psychosis or might as well reflect some adolescent unease are commonplace in psychiatry...
2017: PloS One
https://www.readbyqxmd.com/read/28723520/bone-scan-index-as-an-imaging-biomarker-in-metastatic-castration-resistant-prostate-cancer-a-multicentre-study-based-on-patients-treated-with-abiraterone-acetate-zytiga-in-clinical-practice
#11
Mariana Reza, Mattias Ohlsson, Reza Kaboteh, Aseem Anand, Ingela Franck-Lissbrant, Jan-Erik Damber, Anders Widmark, Camilla Thellenberg-Karlsson, Lars Budäus, Thomas Steuber, Till Eichenauer, Per Wollmer, Lars Edenbrandt, Elin Trägårdh, Anders Bjartell
BACKGROUND: Abiraterone acetate (AA) prolongs survival in metastatic castration-resistant prostate cancer (mCRPC) patients. To measure treatment response accurately in bone, quantitative methods are needed. The Bone Scan Index (BSI), a prognostic imaging biomarker, reflects the tumour burden in bone as a percentage of the total skeletal mass calculated from bone scintigraphy. OBJECTIVE: To evaluate the value of BSI as a biomarker for outcome evaluation in mCRPC patients on treatment with AA according to clinical routine...
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723342/molecular-analysis-of-circulating-free-dna-from-lung-cancer-patients-in-routine-laboratory-practice-a-cross-platform-comparison-of-three-different-molecular-methods-for-mutation-detection
#12
Stephan Bartels, Sascha Persing, Britta Hasemeier, Elisa Schipper, Hans Kreipe, Ulrich Lehmann
Cell-free DNA (cfDNA), which is isolated from blood plasma, represents a noninvasive source for the detection of mutations conferring resistance against epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in non-small-cell lung cancer patients. In advanced disease stages, performing regular biopsies is often not possible because of the general health condition of the patients. Furthermore, a biopsy of a single tumor lesion or metastasis may not reflect the heterogeneous genotype of the tumor and its metastases...
July 16, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28723249/experiences-of-individuals-with-visual-impairments-in-integrated-physical-education-a-retrospective-study
#13
Justin A Haegele, Xihe Zhu
PURPOSE: The purpose of this retrospective study was to examine the experiences of adults with visual impairments during school-based integrated physical education (PE). METHOD: An interpretative phenomenological analysis (IPA) research approach was used and 16 adults (ages 21-48 years; 10 women, 6 men) with visual impairments acted as participants for this study. The primary sources of data were semistructured audiotaped telephone interviews and reflective field notes, which were recorded during and immediately following each interview...
July 19, 2017: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/28723080/an-orthogonal-multi-input-integration-system-to-control-gene-expression-in-escherichia-coli
#14
Fabio Annunziata, Antoni Matyjaszkiewicz, Gianfranco Fiore, Claire Grierson, Lucia Marucci, Mario di Bernardo, Nigel Savery
In many biotechnological applications, it is useful for gene expression to be regulated by multiple signals, as this allows the programming of complex behaviour. Here we implement, in Escherichia coli, a system that compares the concentration of two signal molecules, and tunes GFP expression proportionally to their relative abundance. The computation is performed via molecular titration between an orthogonal σ factor and its cognate anti-σ factor. We use mathematical modelling and experiments to show that the computation system is predictable and able to adapt GFP expression dynamically to a wide range of combinations of the two signals, and our model qualitatively captures most of these behaviours...
July 19, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28722037/magnetite-hollow-microspheres-with-a-broad-absorption-bandwidth-of-11-9-ghz-toward-promising-lightweight-electromagnetic-microwave-absorption
#15
Ivan Shanenkov, Alexander Sivkov, Alexander Ivashutenko, Viktor Zhuravlev, Qing Guo, Liping Li, Guangshe Li, GuoDong Wei, Wei Han
High-performance magnetite-based hollow spheres with the advantages of low density and low loading content are promising as an ideal lightweight electromagnetic (EM) wave absorption candidate. However, the effective preparation methods for these hollow spheres are still limited, and as a result, materials design and practical applications based on their size-dependent EM microwave attenuation properties are poorly accessible. In this study, high quality magnetite hollow spheres were successfully prepared by a simple, fast, one-step, and scalable plasma dynamic method with sole use of inexpensive precursors (oxygen and mild steel)...
July 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28721912/exosomes-and-exosomal-micrornas-in-prostate-cancer-radiation-therapy
#16
REVIEW
Bijaya Malla, Kathrin Zaugg, Erik Vassella, Daniel M Aebersold, Alan Dal Pra
Despite current risk stratification systems using traditional clinicopathologic factors, many localized and locally advanced prostate cancers fail radical treatment (ie, radical prostatectomy, radiation therapy with or without androgen deprivation therapy). Therefore, a pressing need exists for enhanced methods of disease stratification through novel prognostic and predictive tools that can reliably be applied in clinical practice. Exosomes are 50- to 150-nm small vesicles released by cancer cells that reflect the genetic and nongenetic materials of parent cancer cells...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28721761/-always-listen-reflect-and-learn
#17
(no author information available yet)
Jodie Deards, winner of the RCNi Nurse Awards 2017 Commitment to Carers category, earned her degree as part of Australia's first cohort of university-trained nurses in 1993. She came to the UK on a two-year working holiday in 2000 but stayed. After 10 years in the renal unit at Lister Hospital in Stevenage, she took up posts as a community diabetes specialist nurse, practice nurse and community matron. Her current role as carers lead has brought her back to Lister Hospital, part of East and North Hertfordshire NHS Trust...
July 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28721117/experiential-learning-in-physical-therapy-education
#18
Susan N Smith, Amy F Crocker
BACKGROUND AND PURPOSE: Experiential learning can provide students in entry-level physical therapy (PT) education programs the opportunity to practice skills and techniques, learned in the classroom, in a real-world setting. Experiential learning is currently being utilized in all entry-level PT programs in the form of professional practice experiences but may be integrated throughout the curriculum to enhance student engagement and knowledge application and retention. The purpose of this paper is to express the need for increased integration of experiential learning into entry-level PT education curricula...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28720908/negative-reflecting-meta-mirrors
#19
Rui Yang, Dong Li, Dongxing Gao, Aofang Zhang, Bowei Hu, Pei Yang, Zhenya Lei, Jiacheng Li
Using the gradient phase discontinuities that meta-mirrors provide, we show that the incident wave can be reflected anomalously with a broad angle range of negative reflections. Such reversed behaviors promote the immediate applications for the planar meta-mirrors to steer the signals more arbitrarily and the convex meta-mirrors to focus and collimate electromagnetic fields. We practically implement these negative reflecting meta-mirrors through an arrangement of subwavelength ring patches and generate the desired phase distribution by also considering the incident angle...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720114/effects-of-the-equip-quasi-experimental-study-testing-a-collaborative-quality-improvement-approach-for-maternal-and-newborn-health-care-in-tanzania-and-uganda
#20
P Waiswa, F Manzi, G Mbaruku, A K Rowe, M Marx, G Tomson, T Marchant, B A Willey, J Schellenberg, S Peterson, C Hanson
BACKGROUND: Quality improvement is a recommended strategy to improve implementation levels for evidence-based essential interventions, but experience of and evidence for its effects in low-resource settings are limited. We hypothesised that a systemic and collaborative quality improvement approach covering district, facility and community levels, supported by report cards generated through continuous household and health facility surveys, could improve the implementation levels and have a measurable population-level impact on coverage and quality of essential services...
July 18, 2017: Implementation Science: IS
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