J-P Pelletier, C Cooper, C Peterfy, J-Y Reginster, M-L Brandi, O Bruyère, R Chapurlat, F Cicuttini, P G Conaghan, M Doherty, H Genant, G Giacovelli, M C Hochberg, D J Hunter, J A Kanis, M Kloppenburg, J-D Laredo, T McAlindon, M Nevitt, J-P Raynauld, R Rizzoli, C Zilkens, F W Roemer, J Martel-Pelletier, A Guermazi
Knee osteoarthritis is associated with structural changes in the joint. Despite its many drawbacks, radiography is the current standard for evaluating joint structure in trials of potential disease-modifying osteoarthritis drugs. MRI is a non-invasive alternative that provides comprehensive imaging of the whole joint. Frequently used MRI measurements in knee osteoarthritis are cartilage volume and thickness; others include synovitis, synovial fluid effusions, bone marrow lesions (BML) and meniscal damage. Joint replacement is considered a clinically relevant outcome in knee osteoarthritis; however, its utility in clinical trials is limited...
October 2013: Annals of the Rheumatic Diseases