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https://www.readbyqxmd.com/read/27809891/chondroitin-sulfate-efficacy-versus-celecoxib-on-knee-osteoarthritis-structural-changes-using-magnetic-resonance-imaging-a-2-year-multicentre-exploratory-study
#1
Jean-Pierre Pelletier, Jean-Pierre Raynauld, André D Beaulieu, Louis Bessette, Frédéric Morin, Artur J de Brum-Fernandes, Philippe Delorme, Marc Dorais, Patrice Paiement, François Abram, Johanne Martel-Pelletier
BACKGROUND: In osteoarthritis (OA) treatment, although chondroitin sulfate (CS) was found in a number of studies using radiography to have a structure-modifying effect, to date CS use is still under debate. A clinical study using quantitative magnetic resonance imaging (qMRI) is therefore of the utmost importance. Here we report data from a 24-month, randomised, double-blind, double-dummy, controlled, comparative exploratory study of knee OA. The primary endpoint was to determine the effect of CS 1200 mg/day versus celecoxib 200 mg/day on cartilage volume loss (CVL) in the lateral compartment over time as measured by qMRI...
November 3, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26881338/long-term-effects-of-glucosamine-and-chondroitin-sulfate-on-the-progression-of-structural-changes-in-knee-osteoarthritis-six-year-followup-data-from-the-osteoarthritis-initiative
#2
Jean-Pierre Raynauld, Jean-Pierre Pelletier, François Abram, Pierre Dodin, Philippe Delorme, Johanne Martel-Pelletier
OBJECTIVE: To examine the long-term (6-year) effect of combined glucosamine (Glu) and chondroitin sulfate (CS) treatment on cartilage volume in knee osteoarthritis (OA). METHODS: Participants were from the Osteoarthritis Initiative progression and incidence subcohorts, had magnetic resonance imaging (MRI) of the target knee at baseline and 6 years, joint space width >1 mm, and data available on Glu/CS consumption (n = 1,593). They were stratified into 2 main groups based on whether or not they had medial meniscal extrusion at baseline...
October 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/26660640/the-levels-of-the-adipokines-adipsin-and-leptin-are-associated-with-knee-osteoarthritis-progression-as-assessed-by-mri-and-incidence-of-total-knee-replacement-in-symptomatic-osteoarthritis-patients-a-post-hoc-analysis
#3
Johanne Martel-Pelletier, Jean-Pierre Raynauld, Marc Dorais, François Abram, Jean-Pierre Pelletier
OBJECTIVE: Limited studies have explored the association between adipokines and knee OA structural progression using quantitative MRI (qMRI), and very few have included total knee replacement (TKR) as a disease outcome. The objective of this study was to compare serum levels of five adipokines to cartilage volume loss (CVL) and investigate their predictive value for TKR. METHODS: The according-to-protocol population (n = 138) of a knee OA trial was used. Serum levels of adipsin (complement factor D), leptin, adiponectin, resistin and serpin E1, and cartilage volume were determined at baseline and 24 months with specific ELISAs and qMRI, respectively...
April 2016: Rheumatology
https://www.readbyqxmd.com/read/26602915/agreement-between-physicians-and-nurses-clinical-decisions-for-the-management-of-the-fracture-liaison-service-4ifls-the-lucky-bone%C3%A2-program
#4
A Senay, J Delisle, J P Raynauld, S N Morin, J C Fernandes
UNLABELLED: We determined if nurses can manage osteoporotic fractures in a fracture liaison service by asking a rheumatologist and an internist to assess their clinical decisions. Experts agreed on more than 94 % of all nurses' actions for 525 fragility fracture patients, showing that their management is efficient and safe. INTRODUCTION: A major care gap exists in the investigation of bone fragility and initiation of treatment for individuals who have sustained a fragility fracture...
April 2016: Osteoporosis International
https://www.readbyqxmd.com/read/26094904/impact-of-disease-treatments-on-the-progression-of-knee-osteoarthritis-structural-changes-related-to-meniscal-extrusion-data-from-the-oai-progression-cohort
#5
Camille Roubille, Johanne Martel-Pelletier, François Abram, Marc Dorais, Philippe Delorme, Jean-Pierre Raynauld, Jean-Pierre Pelletier
OBJECTIVE: In the perspective of personalized management of osteoarthritis (OA), a clinically relevant concern is the impact of meniscal extrusion (Ext) on response to treatment. This study aimed at determining the effects of conventional OA pharmacological treatments and those of the combination of glucosamine and chondroitin sulfate (Glu/CS) on knee structural changes in the presence or absence of Ext, using data from the progression cohort of the Osteoarthritis Initiative. METHODS: In this longitudinal study, knee OA participants were stratified based on whether (+) or not (-) they received analgesics/NSAIDs (+ and -analgesics/NSAIDs) and/or Glu/CS (+ and -Glu/CS) for 24 consecutive months and on the presence (Ext+) or absence (Ext-) of medial meniscal extrusion at baseline...
December 2015: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/25952343/oarsi-clinical-trials-recommendations-knee-imaging-in-clinical-trials-in-osteoarthritis
#6
REVIEW
D J Hunter, R D Altman, F Cicuttini, M D Crema, J Duryea, F Eckstein, A Guermazi, R Kijowski, T M Link, J Martel-Pelletier, C G Miller, T J Mosher, R E Ochoa-Albíztegui, J-P Pelletier, C Peterfy, J-P Raynauld, F W Roemer, S M Totterman, G E Gold
Significant advances have occurred in our understanding of the pathogenesis of knee osteoarthritis (OA) and some recent trials have demonstrated the potential for modification of the disease course. The purpose of this expert opinion, consensus driven exercise is to provide detail on how one might use and apply knee imaging in knee OA trials. It includes information on acquisition methods/techniques (including guidance on positioning for radiography, sequence/protocol recommendations/hardware for magnetic resonance imaging (MRI)); commonly encountered problems (including positioning, hardware and coil failures, sequences artifacts); quality assurance (QA)/control procedures; measurement methods; measurement performance (reliability, responsiveness, validity); recommendations for trials; and research recommendations...
May 2015: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/25888851/meniscal-extrusion-promotes-knee-osteoarthritis-structural-progression-protective-effect-of-strontium-ranelate-treatment-in-a-phase-iii-clinical-trial
#7
RANDOMIZED CONTROLLED TRIAL
Camille Roubille, Johanne Martel-Pelletier, Jean-Pierre Raynauld, François Abram, Marc Dorais, Philippe Delorme, Jean-Pierre Pelletier
INTRODUCTION: To evaluate the impact of meniscal extrusion (Ext) on knee osteoarthritis (OA) structural progression and on response to strontium ranelate (SrRan) treatment at 36 months in patients with (+) or without (-) Ext, in association (+) or not (-) with bone marrow lesions (BML) in the medial compartment using X-rays (JSW) and qMRI. METHODS: Patients from the qMRI substudy of the SEKOIA trial (SrRan 1 g/day, n = 113; SrRan 2 g/day, n = 105; placebo, n = 112) were stratified based on whether meniscal extrusion and/or BML were present or not in the medial compartment...
2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/25778112/magnetic-resonance-imaging-assessed-vastus-medialis-muscle-fat-content-and-risk-for-knee-osteoarthritis-progression-relevance-from-a-clinical-trial
#8
RANDOMIZED CONTROLLED TRIAL
Jean-Pierre Raynauld, Jean-Pierre Pelletier, Camille Roubille, Marc Dorais, François Abram, Wei Li, Yuanyuan Wang, Jessica Fairley, Flavia M Cicuttini, Johanne Martel-Pelletier
OBJECTIVE: Studies have proposed vastus medialis (VM) muscle cross-sectional area change as a variable associated with cartilage volume loss in knee osteoarthritis (OA). However, the VM also includes fat (%Fat), which may influence knee function. This study analyzed the VM area and %Fat data, separately and in combination, to predict symptoms, cartilage volume loss, and bone marrow lesion (BML) change in knee OA. METHODS: This study included the according-to-protocol population (n = 143) of a 2-year knee OA randomized clinical trial having magnetic resonance imaging at baseline and 2 years...
October 2015: Arthritis Care & Research
https://www.readbyqxmd.com/read/25546011/surgically-placed-abdominal-wall-catheters-on-postoperative-analgesia-and-outcomes-after-living-liver-donation
#9
James Khan, Joel Katz, Janice Montbriand, Salima Ladak, Stuart McCluskey, Coimbatore Srinivas, Raynauld Ko, David Grant, Ashleene Bradbury, Yannick LeManach, Hance Clarke
Living donor liver resections are associated with significant postoperative pain. Epidural analgesia is the gold standard for postoperative pain management, although it is often refused or contraindicated. Surgically placed abdominal wall catheters (AWCs) are a novel pain modality that can potentially provide pain relief for those patients who are unable to receive an epidural. A retrospective review was performed at a single center. Patients were categorized according to their postoperative pain modality: intravenous (IV) patient-controlled analgesia (PCA), AWCs with IV PCA, or patient-controlled epidural analgesia (PCEA)...
April 2015: Liver Transplantation
https://www.readbyqxmd.com/read/25500708/an-autoimmune-myositis-overlap-syndrome-associated-with-autoantibodies-to-nuclear-pore-complexes-description-and-long-term-follow-up-of-the-anti-nup-syndrome
#10
Jean-Luc Senécal, Catherine Isabelle, Marvin J Fritzler, Ira N Targoff, Rose Goldstein, Michel Gagné, Jean-Pierre Raynauld, France Joyal, Yves Troyanov, Marie-Christine Dabauvalle
Autoimmune myositis encompasses various myositis-overlap syndromes, each being identified by the presence of serum marker autoantibodies. We describe a novel myositis-overlap syndrome in 4 patients characterized by the presence of a unique immunologic marker, autoantibodies to nuclear pore complexes. The clinical phenotype was characterized by prominent myositis in association with erosive, anti-CCP, and rheumatoid factor-positive arthritis, trigeminal neuralgia, mild interstitial lung disease, Raynaud phenomenon, and weight loss...
November 2014: Medicine (Baltimore)
https://www.readbyqxmd.com/read/25500701/redefining-dermatomyositis-a-description-of-new-diagnostic-criteria-that-differentiate-pure-dermatomyositis-from-overlap-myositis-with-dermatomyositis-features
#11
Yves Troyanov, Ira N Targoff, Marie-Pier Payette, Jean-Pierre Raynauld, Suzanne Chartier, Jean-Richard Goulet, Josiane Bourré-Tessier, Eric Rich, Tamara Grodzicky, Marvin J Fritzler, France Joyal, Martial Koenig, Jean-Luc Senécal
Dermatomyositis (DM) is a major clinical subset of autoimmune myositis (AIM). The characteristic DM rash (Gottron papules, heliotrope rash) and perifascicular atrophy at skeletal muscle biopsy are regarded as specific features for this diagnosis. However, new concepts are challenging the current definition of DM. A modified Bohan and Peter classification of AIM was proposed in which the core concept was the inclusion of the diagnostic significance of overlap connective tissue disease features. In this clinical classification, a DM rash in association with myositis in the absence of overlap features indicates a diagnosis of pure DM...
November 2014: Medicine (Baltimore)
https://www.readbyqxmd.com/read/25497320/the-presence-of-meniscal-lesions-is-a-strong-predictor-of-neuropathic-pain-in-symptomatic-knee-osteoarthritis-a-cross-sectional-pilot-study
#12
MULTICENTER STUDY
Camille Roubille, Jean-Pierre Raynauld, François Abram, Patrice Paiement, Marc Dorais, Philippe Delorme, Louis Bessette, André D Beaulieu, Johanne Martel-Pelletier, Jean-Pierre Pelletier
INTRODUCTION: Pain in osteoarthritis (OA) has been classically attributed to joint structural damage. Disparity between the degree of radiographic structural damage and the severity of symptoms implies that factors other than the joint pathology itself contribute to the pain. Peripheral and central sensitization have been suggested as two of the underlying mechanisms that contribute to pain in OA. The aim of this study was to explore in symptomatic knee OA patients, the structural changes assessed by magnetic resonance imaging (MRI) that could be used as markers of neuropathic pain (NP)...
2014: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/24950773/medial-open-transversus-abdominis-plane-motap-catheters-for-analgesia-following-open-liver-resection-study-protocol-for-a-randomized-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
Paul Karanicolas, Sean Cleary, Paul McHardy, Stuart McCluskey, Jason Sawyer, Salima Ladak, Calvin Law, Alice Wei, Natalie Coburn, Raynauld Ko, Joel Katz, Alex Kiss, James Khan, Srinivas Coimbatore, Jenny Lam-McCulloch, Hance Clarke
BACKGROUND: The current standard for pain control following liver surgery is intravenous, patient-controlled analgesia (IV PCA) or epidural analgesia. We have developed a modification of a regional technique called medial open transversus abdominis plane (MOTAP) catheter analgesia. The MOTAP technique involves surgically placed catheters through the open surgical site into a plane between the internal oblique muscle and the transverse abdominis muscle superiorly. The objective of this trial is to assess the efficacy of this technique...
2014: Trials
https://www.readbyqxmd.com/read/24534711/republished-value-of-biomarkers-in-osteoarthritis-current-status-and-perspectives
#14
M Lotz, J Martel-Pelletier, C Christiansen, M-L Brandi, O Bruyère, R Chapurlat, J Collette, C Cooper, G Giacovelli, J A Kanis, M A Karsdal, V Kraus, W F Lems, I Meulenbelt, J-P Pelletier, J-P Raynauld, S Reiter-Niesert, R Rizzoli, L J Sandell, W E Van Spil, J-Y Reginster
Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci, ligaments and subchondral bone, and synovial inflammation. Biomarkers are being developed to quantify joint remodelling and disease progression. This article was prepared following a working meeting of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis convened to discuss the value of biochemical markers of matrix metabolism in drug development in osteoarthritis. The best candidates are generally molecules or molecular fragments present in cartilage, bone or synovium and may be specific to one type of joint tissue or common to them all...
March 2014: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/24336337/first-line-analysis-of-the-effects-of-treatment-on-progression-of-structural-changes-in-knee-osteoarthritis-over-24-months-data-from-the-osteoarthritis-initiative-progression-cohort
#15
Johanne Martel-Pelletier, Camille Roubille, François Abram, Marc C Hochberg, Marc Dorais, Philippe Delorme, Jean-Pierre Raynauld, Jean-Pierre Pelletier
OBJECTIVE: To determine, using data from participants enrolled in the progression cohort of the OAI, the effects of conventional osteoarthritis (OA) pharmacological treatment and those of the combination of glucosamine and chondroitin sulfate (Glu/CS) on knee structural changes. METHODS: Six hundred patients with knee OA were stratified based on whether or not they received for 24 consecutive months the OA conventional pharmacological treatment and/or Glu/CS. The main outcomes were knee structural changes, including the loss of joint space width (JSW) and of cartilage volume measured by quantitative MRI...
March 2015: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/24297379/disease-modifying-effect-of-strontium-ranelate-in-a-subset-of-patients-from-the-phase-iii-knee-osteoarthritis-study-sekoia-using-quantitative-mri-reduction-in-bone-marrow-lesions-protects-against-cartilage-loss
#16
RANDOMIZED CONTROLLED TRIAL
Jean-Pierre Pelletier, Camille Roubille, Jean-Pierre Raynauld, François Abram, Marc Dorais, Philippe Delorme, Johanne Martel-Pelletier
OBJECTIVE: To explore, using MRI, the disease-modifying effect of strontium ranelate (SrRan) treatment on cartilage volume loss (CVL) and bone marrow lesions (BMLs) in a subset of patients from a Phase III clinical trial in knee osteoarthritis (OA) (SrRan Efficacy in Knee OsteoarthrItis triAl (SEKOIA)). MATERIAL AND METHODS: Patients with primary symptomatic knee OA were randomised to receive either SrRan 1 g/day or 2 g/day or placebo (SEKOIA study). A subset of these patients had MRIs at baseline, 12, 24 and 36 months to assess the knee cartilage volume and BMLs...
February 2015: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/23897772/value-of-biomarkers-in-osteoarthritis-current-status-and-perspectives
#17
REVIEW
M Lotz, J Martel-Pelletier, C Christiansen, M-L Brandi, O Bruyère, R Chapurlat, J Collette, C Cooper, G Giacovelli, J A Kanis, M A Karsdal, V Kraus, W F Lems, I Meulenbelt, J-P Pelletier, J-P Raynauld, S Reiter-Niesert, R Rizzoli, L J Sandell, W E Van Spil, J-Y Reginster
Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci, ligaments and subchondral bone, and synovial inflammation. Biomarkers are being developed to quantify joint remodelling and disease progression. This article was prepared following a working meeting of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis convened to discuss the value of biochemical markers of matrix metabolism in drug development in osteoarthritis. The best candidates are generally molecules or molecular fragments present in cartilage, bone or synovium and may be specific to one type of joint tissue or common to them all...
November 2013: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/23887285/what-is-the-predictive-value-of-mri-for-the-occurrence-of-knee-replacement-surgery-in-knee-osteoarthritis
#18
REVIEW
J-P Pelletier, C Cooper, C Peterfy, J-Y Reginster, M-L Brandi, O Bruyère, R Chapurlat, F Cicuttini, P G Conaghan, M Doherty, H Genant, G Giacovelli, M C Hochberg, D J Hunter, J A Kanis, M Kloppenburg, J-D Laredo, T McAlindon, M Nevitt, J-P Raynauld, R Rizzoli, C Zilkens, F W Roemer, J Martel-Pelletier, A Guermazi
Knee osteoarthritis is associated with structural changes in the joint. Despite its many drawbacks, radiography is the current standard for evaluating joint structure in trials of potential disease-modifying osteoarthritis drugs. MRI is a non-invasive alternative that provides comprehensive imaging of the whole joint. Frequently used MRI measurements in knee osteoarthritis are cartilage volume and thickness; others include synovitis, synovial fluid effusions, bone marrow lesions (BML) and meniscal damage. Joint replacement is considered a clinically relevant outcome in knee osteoarthritis; however, its utility in clinical trials is limited...
October 2013: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/23377862/gabapentin-reduces-preoperative-anxiety-and-pain-catastrophizing-in-highly-anxious-patients-prior-to-major-surgery-a-blinded-randomized-placebo-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Hance Clarke, Kyle R Kirkham, Beverley A Orser, Rita Katznelson, Nicholas Mitsakakis, Raynauld Ko, Adam Snyman, Martin Ma, Joel Katz
INTRODUCTION: Gabapentin is increasingly being used for the treatment of postoperative pain and a variety of psychiatric diseases, including chronic anxiety disorders. Trials have reported mixed results when gabapentin has been administered for the treatment of preoperative anxiety. We tested the hypothesis that gabapentin 1,200 mg vs placebo would reduce preoperative anxiety in patients who exhibit moderate to high preoperative anxiety. METHODS: A blinded randomized controlled trial was conducted from September 2009 to June 2011 at the Toronto General Hospital...
May 2013: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/23139244/assessment-of-cartilage-changes-over-time-in-knee-osteoarthritis-disease-modifying-osteoarthritis-drug-trials-using-semiquantitative-and-quantitative-methods-pros-and-cons
#20
RANDOMIZED CONTROLLED TRIAL
Lukas Martin Wildi, Johanne Martel-Pelletier, François Abram, Thomas Moser, Jean-Pierre Raynauld, Jean-Pierre Pelletier
OBJECTIVE: To evaluate the impact of 2 magnetic resonance imaging (MRI) sequences on cartilage defect assessment in knee osteoarthritis (OA) patients and the sensitivity to change over time comparing cartilage defect (semiquantitative) with cartilage volume loss (quantitative) methods. METHODS: Gradient-echo (GRE) and intermediate-weighted fast spin-echo (IW-FSE) sequences were compared. Knee OA MRIs were from two 2-year studies (cohort 1, n = 55; cohort 2, n = 143)...
May 2013: Arthritis Care & Research
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