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https://www.readbyqxmd.com/read/28813123/pharmacotherapy-for-hypertension-in-adults-aged-18-to-59-years
#1
REVIEW
Vijaya M Musini, Francois Gueyffier, Lorri Puil, Douglas M Salzwedel, James M Wright
BACKGROUND: Hypertension is an important risk factor for adverse cardiovascular events including stroke, myocardial infarction, heart failure and renal failure. The main goal of treatment is to reduce these events. Systematic reviews have shown proven benefit of antihypertensive drug therapy in reducing cardiovascular morbidity and mortality but most of the evidence is in people 60 years of age and older. We wanted to know what the effects of therapy are in people 18 to 59 years of age...
August 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28813018/biophysical-and-computational-studies-of-the-vcci-vmip-ii-complex
#2
Anna F Nguyen, Nai-Wei Kuo, Laura J Showalter, Ricardo Ramos, Cynthia M Dupureur, Michael E Colvin, Patricia J LiWang
Certain viruses have the ability to subvert the mammalian immune response, including interference in the chemokine system. Poxviruses produce the chemokine binding protein vCCI (viral CC chemokine inhibitor; also called 35K), which tightly binds to CC chemokines. To facilitate the study of vCCI, we first provide a protocol to produce folded vCCI from Escherichia coli (E. coli.) It is shown here that vCCI binds with unusually high affinity to viral Macrophage Inflammatory Protein-II (vMIP-II), a chemokine analog produced by the virus, human herpesvirus 8 (HHV-8)...
August 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28812969/functional-expression-of-bmp7-receptors-in-oral-epithelial-cells-interleukin-17f-production-in-response-to-bmp7
#3
Kensuke Nishio, Yasumasa Ozawa, Hisanori Ito, Takashi Kifune, Tatsuya Narita, Toshimitsu Iinuma, Nobuhito Gionhaku, Masatake Asano
BACKGROUND: Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) superfamily. Recently, BMP7 has been demonstrated to be produced by salivary glands and contribute to embryonic branching in mice. The BMP7 in saliva is thought to be delivered to the oral cavity and is expected to contact with stratified squamous epithelial cells which line the surface of oral mucosa. In this study, we attempted to investigate the effects of BMP7 on oral epithelial cells...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28812931/advocacy-and-public-policy-perceptions-and-involvement-of-master-certified-health-education-specialists
#4
Dianne L Kerr, Emily Van Wasshenova, Rachel Mahas, F Jeannine Everhart, Amy Thompson, Debra Boardley
Master Certified Health Education Specialists (MCHES; n = 186) participated in a mail survey on advocacy and public policy. Over half of participants reported that they had contacted a public official or provided policy-related information to consumers or other professionals. Participants identified barriers and benefits to influencing public policy. The greatest benefit was identified as improving the health or welfare of the public while the greatest barrier was that they were busy with other priorities. Participants also described their level of involvement, knowledge, training in advocacy, and their self-efficacy in performing various advocacy activities...
September 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/28812872/effect-of-mineral-dissolution-precipitation-and-co2-exsolution-on-co2-transport-in-geological-carbon-storage
#5
Ruina Xu, Rong Li, Jin Ma, Di He, Peixue Jiang
Geological carbon sequestration (GCS) in deep saline aquifers is an effective means for storing carbon dioxide to address global climate change. As the time after injection increases, the safety of storage increases as the CO2 transforms from a separate phase to CO2(aq) and HCO3(-) by dissolution and then to carbonates by mineral dissolution. However, subsequent depressurization could lead to dissolved CO2(aq) escaping from the formation water and creating a new separate phase which may reduce the GCS system safety...
August 16, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28812775/polymorphic-light-eruption-and-il-1-family-members-any-difference-with-allergic-contact-dermatitis
#6
S Lembo, G Caiazzo, N Balato, G Monfrecola, V Patra, P Wolf, A Balato
Polymorphic light eruption (PLE) is described as a delayed-type hypersensitivity reaction (DTHR) toward a de novo light-induced antigen, yet to be identified. In effect, the inflammatory pathways of PLE and allergic contact dermatitis (ACD) share common patterns in terms of the mediators involved from the innate and adaptive immune system participating in the DTHR. As we have previously highlighted the role of interleukin (IL)-1 family members in ACD, we hypothesised that the same mediators could have similar functions in PLE...
August 16, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28812747/identifying-the-charge-generation-dynamics-in-cs-based-triple-cation-mixed-perovskite-solar-cells
#7
Manuel Salado, Ramesh K Kokal, Laura Calio, Samrana Kazim, Melepurath Deepa, Shahzada Ahmad
Triple cation based perovskite solar cells offer enhanced moisture tolerance and stability compared to mixed perovskites. Slight substitution of methyl ammonium or formamidinium cation by cesium (Cs(+)), was also reported to eliminate halide segregation due to its smaller size. To elucidate the device kinetics and understand the role of the Cs, we undertook different modes of scanning probe microscopy and electrochemical impedance spectroscopy (EIS) experiments. Kelvin probe force microscopy revealed that the incorporation of the Cs cation increases the contact potential difference (CPD), this CPD further increases when Spiro-OMeTAD is used as a hole transport material...
August 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28812544/photoelectric-response-properties-under-uv-red-light-irradiation-of-zno-nanorod-arrays-coated-with-vertically-aligned-mos2-nanosheets
#8
Yuzhu Zhang, Jianping Xu, Shaobo Shi, Yanyan Gao, Xiangguo Zhao, Chengtai Wei, Xiaosong Zhang, Lan Li
MoS2 with layered structure and distinct physical properties has attracted attention for electronic or optoelectronic devices. The photoelectric response properties of MoS2/ZnO heterojunctions based devices fabricated by spin-coating MoS2 nanosheets solutions on ZnO nanorod arrays (NRs) were investigated. The results revealed that MoS2 nanosheets were vertically aligned on the surface of ZnO NRs and the devices exhibit good photoresponse stability and reproducibility under UV and red light illuminations. The vertically aligned MoS2 nanosheets facilitate the fast photogenerated carrier separation and transport...
August 16, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28812540/quantifying-transmission
#9
Mark Woolhouse
Transmissibility is the defining characteristic of infectious diseases. Quantifying transmission matters for understanding infectious disease epidemiology and designing evidence-based disease control programs. Tracing individual transmission events can be achieved by epidemiological investigation coupled with pathogen typing or genome sequencing. Individual infectiousness can be estimated by measuring pathogen loads, but few studies have directly estimated the ability of infected hosts to transmit to uninfected hosts...
July 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28812530/feline-herpesvirus-pneumonia-investigations-into-the-pathogenesis
#10
Josep Maria Monne Rodriguez, Gail Leeming, Kernt Köhler, Anja Kipar
Feline herpesvirus type 1 (FeHV-1) is one of the etiological agents of feline respiratory disease. FeHV-1 is an epitheliotropic and cytopathic virus that mainly causes rhinitis and conjunctivitis, although pneumonia is also occasionally seen. In this study, the authors investigated the pathogenesis of FeHV-1-associated pneumonia, comparing natural cases with viral infection of tracheal ring and cell cultures in vitro, using histology, immunohistology, double immunofluorescence, and transmission electron microscopy as investigative tools...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28812476/developing-nurses-transformational-leadership-skills
#11
Shelly Ann Fischer
Healthcare is a complex area with significant potential for service improvement despite the effects of increasing economic and social pressures on the quality and safety of patient care. As the largest group of healthcare professionals in direct contact with patients, nurses are well positioned to contribute to improvements in healthcare services and to the development of new policies. To influence healthcare improvements and policies effectively, nurses require leadership skills. Historically, it was thought that only nurses in management roles required leadership skills; however, the ability to influence change is a requirement at all levels of clinical practice...
August 16, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28812396/the-influence-of-lower-limb-prostheses-technology-on-paracanoeing-time-trial-performance
#12
Shelley Ellis, Andrew Callaway, Bryce Dyer
Within the Paracanoeing discipline, it is important to ensure that appropriate control is achieved by a paddler with a disability. However, this Paralympic Games discipline has seen very little attention to date. The aims of this study were to understand the kinematic impact to a paracanoeist when not utilizing the use of a prosthetic lower-limb. A kayaker with a uni-lateral transfemoral amputation completed several 200 m maximal efforts both with and without their prosthesis. When the prosthetic limb was removed, there were significant differences found in stroke rate, stroke speed, stroke length and overall power output...
August 16, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28812363/influence-of-oxygen-vacancies-on-the-frictional-properties-of-nanocrystalline-zinc-oxide-thin-films-in-ambient-conditions
#13
Huan-Pu Chang, En-De Chu, Yu-Ting Yeh, Yueh-Chun Wu, Fang-Yuh Lo, Wei-Hua Wang, Ming-Yau Chern, Hsiang-Chih Chiu
Oxygen vacancy is the most studied point defect and has been found to significantly influence the physical properties of zinc oxide (ZnO). By using atomic force microscopy (AFM), we show that the frictional properties on the ZnO surface at the nanoscale greatly depend on the amount of oxygen vacancies present in the surface layer and the ambient humidity. The photocatalytic effect (PCE) is used to qualitatively control the amount of oxygen vacancies in the surface layer of ZnO and reversibly switch the surface wettability between hydrophobic and superhydrophilic states...
August 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28812360/silicon-cations-intermixed-indium-zinc-oxide-interface-for-high-performance-thin-film-transistors-using-a-solution-process
#14
Jae Won Na, You Seung Rim, Hee Jun Kim, Jin Hyeok Lee, Seonghwan Hong, Hyun Jae Kim
Solution-processed amorphous metal-oxide thin-film transistors (TFTs) utilizing an intermixed interface between a metal-oxide semiconductor and a dielectric layer are proposed. In-depth physical characterizations are carried out to verify the existence of the intermixed interface which is inevitably formed by inter-diffusion of cations originated from a thermal process. In particular, when indium zinc oxide (IZO) semiconductor and silicon dioxide (SiO2) dielectric layer are in contact and thermally processed, a Si(4+) intermixed IZO (Si:IZO) interface is created...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28812354/3d-moldable-nanofiber-reinforced-transparent-composites-with-hierarchically-self-assembled-reverse-nacre-like-architecture
#15
Subir Kumar Biswas, Hironari Sano, Md Iftekhar Shams, Hiroyuki Yano
Achieving structural hierarchy and a uniform nanofiller dispersion simultaneously remains highly challenging for obtaining a robust polymer nanocomposite of immiscible components. In this study, a remarkably facile Pickering emulsification approach is developed to fabricate hierarchical composites of immiscible acrylic polymer and native cellulose nanofibers by taking advantage of the dual role of the nanofibers as both the emulsion stabilizer and polymer reinforcement. The composites feature a unique "reverse" nacre-like microstructure reinforced with well-dispersed two-tier hierarchical nanofiber network, leading to a synergistic high strength, modulus, and toughness (20, 50, and 53 times that of neat polymer, respectively), high optical transparency (89%), high flexibility and a drastically low thermal expansion (13 ppm/K, 1/15th of the neat polymer)...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28812252/secondary-fracture-prevention-in-hip-fracture-patients-requires-cooperation-from-general-practitioners
#16
Jan Vaculík, Jan J Stepan, Pavel Dungl, Marek Majerníček, Alexander Čelko, Valér Džupa
Despite individual recommendations on osteoporosis management in patients after hip fracture surgery, addressed by orthopedic surgeons to Czech general practitioners, the patients remained undiagnosed and untreated because of provider-level barriers to post-fracture secondary prevention. PURPOSE: The goal of the study was to assess whether an individual recommendation on osteoporosis treatment addressed to a hip fracture patient's GP would lead to better osteoporosis management. METHODS: Two groups of patients who suffered hip fractures and were treated at the Orthopedic Department were evaluated...
May 18, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28812119/attention-holding-elicited-by-direct-gaze-faces-is-reflected-in-saccadic-peak-velocity
#17
Mario Dalmaso, Luigi Castelli, Giovanni Galfano
Manual response times to peripherally presented targets have been reported to be greater in the presence of task-irrelevant pictorial faces at fixation which establish an eye contact with the observer. This effect is interpreted as evidence that direct-gaze faces hold attention. In three experiments, we investigated whether this attention-holding effect is also reflected in saccadic response times. Participants were asked to make a saccade towards a symbolic target that could appear rightwards or leftwards, in the presence of a task-irrelevant centrally placed face with either direct gaze or closed eyes...
August 10, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28811910/falls-in-scottish-homicide-lessons-for-homicide-reduction-in-mental-health-patients
#18
EDITORIAL
John H M Crichton
The sustained fall in Scottish homicide rates follows crime reduction measures informed by the epidemiology of suicide. The violence reduction unit targeted young men carrying knives in public. The restriction of weapons immediately to hand appears to have caused an absolute fall in homicide just as suicide reduction was observed following changes to domestic gas supply. Further homicide reduction may be accomplished in the domestic setting with targeted changes in kitchen knife design in home safety planning for high-risk households...
August 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28811794/comparing-the-effects-of-two-different-contact-lenses-on-corneal-re-epithelialization-after-corneal-collagen-cross-linking
#19
Yusuf Kocluk, Savas Cetinkaya, Emine Alyamac Sukgen, Murat Günay, Alper Mete
OBJECTIVE: To investigate whether keratoconus (KC) patients who applied the corneal collagen cross-linking (CXL) and two different contact lens (CL) showed any differences in complaints and findings following the CXL. METHODS: This prospective, comparative, double-blind clinical study involved 60 eyes of 60 patients (38 female and 22 male). At the end of the CXL procedure, CL (Balafilcon A) was inserted in 29 patients (Group-1) while CL with different material content (Hioxifilcon A) designed for therapeutic/bandage purposes were inserted in 31 patients (Group-2)...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28811736/mentored-training-to-increase-diversity-among-faculty-in-the-biomedical-sciences-the-nhlbi-summer-institute-programs-to-increase-diversity-sipid-and-the-programs-to-increase-diversity-among-individuals-engaged-in-health-related-research-pride
#20
Treva K Rice, Donna B Jeffe, Josephine E A Boyington, Jared B Jobe, Victor G Dávila-Román, Juan E Gonzalez, Lisa de Las Fuentes, Levi H C Makala, Rita Sarkar, Gbenga G Ogedegbe, Anne L Taylor, Susan Czajkowski, Dabeeru C Rao, Betty S Pace, Girardin Jean-Louis, Mohamed Boutjdir
OBJECTIVE: To report baseline characteristics of junior-level faculty participants in the Summer Institute Programs to Increase Diversity (SIPID) and the Programs to Increase Diversity among individuals engaged in Health-Related Research (PRIDE), which aim to facilitate participants' career development as independent investigators in heart, lung, blood, and sleep research. DESIGN AND SETTING: Junior faculty from groups underrepresented in the biomedical-research workforce attended two, 2-3 week, annual summer research-education programs at one of six sites...
2017: Ethnicity & Disease
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