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https://www.readbyqxmd.com/read/28346966/factor-xii-contact-activation
#1
Clément Naudin, Elena Burillo, Stefan Blankenberg, Lynn Butler, Thomas Renné
Contact activation is the surface-induced conversion of factor XII (FXII) zymogen to the serine protease FXIIa. Blood-circulating FXII binds to negatively charged surfaces and this contact to surfaces triggers a conformational change in the zymogen inducing autoactivation. Several surfaces that have the capacity for initiating FXII contact activation have been identified, including misfolded protein aggregates, collagen, nucleic acids, and platelet and microbial polyphosphate. Activated FXII initiates the proinflammatory kallikrein-kinin system and the intrinsic coagulation pathway, leading to formation of bradykinin and thrombin, respectively...
March 27, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28346844/inactivation-of-i-clostridium-difficile-i-spore-outgrowth-by-synergistic-effects-of-nisin-and-lysozyme
#2
Changhoon Chai, Kyung-Soo Lee, Goo-Sang Imm, Young Soon Kim, Se-Wook Oh
Inactivating <i>Clostridium difficile</i> spores is difficult, as they are resistant to heat, chemicals, and antimicrobials. However, this note describes inactivation of <i>C. difficile</i> spore outgrowth by incubation in a solution containing a germinant (1% w/v sodium taurocholate), co-germinants (1% w/v tryptose and 1% w/v NaCl), and natural antimicrobials (20 nM nisin and 0.2 mM lysozyme). <i>C. difficile</i> spores were resistant to nisin and lysozyme but became susceptible during germination and outgrowth triggered and promoted by sodium taurocholate, tryptose, and NaCl...
March 27, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28346833/arthroscopic-hip-surgery-in-the-elite-athlete-comparison-of-female-and-male-competitive-athletes
#3
Kotaro R Shibata, Shuichi Matsuda, Marc R Safran
BACKGROUND: Few studies have published the results of hip arthroscopic surgery in elite athletes and none studying a significant number of elite female athletes. PURPOSE: (1) To compare sex-based differences in the ability to return to prior competitive sports activity after arthroscopic hip surgery. (2) To compare sex-based differences in the type of sports activity, diagnosis, and treatment in athletes requiring hip arthroscopic surgery. STUDY DESIGN: Cohort study; Level of evidence, 3...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28346797/substituted-borosilicate-glasses-with-improved-osteogenic-capacity-for-bone-tissue-engineering
#4
João S Fernandes, Piergiorgio Gentile, Aileen Crawford, Ricardo A Pires, Paul V Hatton, Rui L Reis
Borosilicate bioactive glasses (BBGs) have shown the capacity to promote higher formation of new bone when compared with silicate bioactive glasses. Herein, we assessed the capacity of BBGs to induce osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) as a function of their substituted divalent cations (Mg(2+), Ca(2+), Sr(2+)). To this purpose, we synthesized BBG particles by melt quenching. The cell viability, proliferation, and morphology (i.e., PrestoBlue(®), PicoGreen(®), and DAPI and Phalloidin stainings, respectively), as well as protein expression (i...
March 27, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28346782/%C3%AE%C2%BA-carrageenan-enhances-the-biomineralization-and-osteogenic-differentiation-of-electrospun-phb-and-phbv-fibers
#5
Nowsheen Goonoo, Behnam Khanbabaee, Marc Steuber, Archana Bhaw-Luximon, Ulrich Jonas, Ullrich Pietsch, Dhanjay Jhurry, Holger Schönherr
Novel electrospun materials for bone tissue engineering were obtained by blending biodegradable polyhydroxybutyrate (PHB) or polyhydroxybutyrate valerate (PHBV) with the anionic sulfated polysaccharide κ-carrageenan (κ-CG) in varying ratios. In both systems, the two components phase separated as shown by FTIR, DSC and TGA. According to the contact angle data, κ-CG was localized preferentially at the fiber surface in PHBV/ κ-CG blends in contrast to PHB/ κ-CG, where the biopolymer was mostly found within the fiber...
March 27, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28346668/demographic-and-preliminary-employment-data-of-the-first-two-graduate-cohorts-from-a-rural-veterinary-school
#6
J H Hyams, S L Raidal, L M Hayes, J Heller
OBJECTIVE: To report initial career experiences and graduate employment destinations 1 and 5 years following graduation of the 67 graduates from the first two graduating classes of the veterinary science program at Charles Sturt University. DESIGN: Online survey of graduates from the 2010 and 2011 cohorts undertaken 12 months following course completion and descriptive data on graduate practice locations 5 years post-graduation. PROCEDURE: Questions covered general demographic information, issues relating to work-life balance and factors influencing vocational choices...
April 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28346306/identification-of-contact-allergens-in-food-handlers-of-kashmir-valley-in-north-india
#7
Insha Latif, Iffat Hassan, Saniya Akhtar, Farhan Rasool, Sumaya Zeerak, Gousia Sheikh
No abstract text is available yet for this article.
March 24, 2017: Dermatitis
https://www.readbyqxmd.com/read/28346278/effects-of-myopic-orthokeratology-on-visual-performance-and-optical-quality
#8
Guihua Liu, Zhi Chen, Feng Xue, Jing Li, Mi Tian, Xingtao Zhou, Ruihua Wei
OBJECTIVES: To analyze the changes in visual performance and optical quality after orthokeratology (ortho-k) treatment and its correlation with the magnitude of lens decentration and the diameter of treatment zone (TxZ). METHODS: A prospective study was conducted in 27 eyes of 27 patients wearing ortho-k contact lens. Area under log contrast sensitivity function (AULCSF), modulation transfer function cutoff values (MTFcutoff), Strehl ratio (SR), and objective scattering index (OSI) were measured and compared before and 1 month after ortho-k lens treatment...
March 24, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28346246/analysis-of-a-patient-intervention-to-reduce-patients-who-leave-without-being-seen-in-an-ophthalmology-dedicated-emergency-room
#9
Alice C Lorch, Maureen Martinez, Matthew Gardiner
Patients who leave without being seen (LWBS) by a medical provider in emergency care settings are a concern because their urgent complaints remain unaddressed. This study aims to characterize the LWBS population in an ophthalmology-dedicated emergency room and to evaluate an intervention designed to decrease the number of these patients. A program of rounding and patient contact in the waiting room of our emergency room was initiated to this end. A patient database was used retrospectively to review 13,124 charts and collect clinical and demographic data on 71 LWBS patients...
March 24, 2017: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/28346225/long-telomeres-protect-against-age-dependent-cardiac-disease-caused-by-notch1-haploinsufficiency
#10
Christina V Theodoris, Foteini Mourkioti, Yu Huang, Sanjeev S Ranade, Lei Liu, Helen M Blau, Deepak Srivastava
Diseases caused by gene haploinsufficiency in humans commonly lack a phenotype in mice that are heterozygous for the orthologous factor, impeding the study of complex phenotypes and critically limiting the discovery of therapeutics. Laboratory mice have longer telomeres relative to humans, potentially protecting against age-related disease caused by haploinsufficiency. Here, we demonstrate that telomere shortening in NOTCH1-haploinsufficient mice is sufficient to elicit age-dependent cardiovascular disease involving premature calcification of the aortic valve, a phenotype that closely mimics human disease caused by NOTCH1 haploinsufficiency...
March 27, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28346217/the-possibility-of-multi-layer-nanofabrication-via-atomic-force-microscope-based-pulse-electrochemical-nanopatterning
#11
Uksu Kim, Noboru Morita, Deug Lee, Martin Jun, Jeong Woo Park
Pulse electrochemical nanopatterning (PECN), a non-contact scanning probe lithography (NC-SPL) process using ultrashort voltage pulses, is based primarily on an electrochemical machining (ECM) process using localized electrochemical oxidation between a sharp tool tip and the sample surface. In this study, nanoscale oxide patterns were formed on silicon Si (100) wafer surfaces via electrochemical surface nanopatterning, by supplying external pulsed currents through non-contact atomic force microscopy. Nanoscale oxide width and height were controlled by modulating the applied pulse duration...
March 27, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28346203/u-s-food-and-drug-administration-inspections-guide-to-a-successful-outcome-for-503a-sterile-compounding-pharmacies
#12
Doug Yoch
The reasons for which pharmaceutical compounding is the focus of intense state and federal scrutiny are now well known. Compounders are faced with an ever-increasing need to prove, by objective standards, the safety, purity, and potency of the formulations they dispense. They must also demonstrate their compliance with regulations often based on current good compounding practices designed for the pharmaceutical industry. In the U.S. today, rigorous unannounced state and federal inspections of compounding facilities are occurring more and more frequently...
March 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28346070/origin-of-disinfection-by-products-in-cheeses
#13
Maria Jose Cardador, Mercedes Gallego, Francisco Prados, José Fernández-Salguero
The disinfection of water, equipment and surfaces in the cheese factory is one of the factors that can originate disinfection by-products (DBPs) in cheeses. This research has focused on studying cheese factories in order to evaluate the individual contribution of each step of the cheese-making process that can contribute to the presence of DBPs in cheeses. Ten factories were selected according to their salting processes (brine salting or dry salting). Each factory was monitored by the collection of six representative samples (factory water supply, brine solution, milk, whey, curd, and cheese) in which the concentrations of up to eight chemicals were detected...
March 27, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28346038/recruitment-and-testing-protocol-in-the-national-eye-health-survey-a-population-based-eye-study-in-australia
#14
Joshua Foreman, Stuart Keel, Peter van Wijngaarden, Hugh R Taylor, Mohamed Dirani
PURPOSE: To present the recruitment and testing methodology of the National Eye Health Survey (NEHS), a population-based study that aimed to determine the prevalence and causes of vision impairment and blindness in Australia. METHODS: Non-Indigenous Australians aged 50 years and older and Indigenous Australians aged 40 years and older were recruited using a door-to-door approach from 30 randomly selected geographical areas, stratified by remoteness. Participants underwent a vision examination, anterior segment assessment, intraocular pressure testing, perimetry, and fundus photography...
March 27, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28345957/xyloglucan-hibiscus-and-propolis-for-the-prevention-of-urinary-tract-infections-results-of-in-vitro-studies
#15
Benito Fraile, Javier Alcover, Mar Royuela, David Rodríguez, Concepción Chaves, Ricardo Palacios, Núria Piqué
AIM: To assess the properties of a medical device containing xyloglucan, propolis and hibiscus to create a bioprotective barrier to avoid the contact of uropathogenic Escherichia coli strains on cell walls in models of intestinal (CacoGoblet) and uroepithelial (RWPE-1) cells (derived from normal human prostate epithelium). MATERIALS & METHODS: Two uropathogenic E. coli strains (expressing type 1 fimbriae and P fimbriae) were used to assess, by electronic microscopy and ELISA, the barrier properties of the medical device...
March 27, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28345932/formation-of-turmeric-based-thin-films-universal-and-transparent-coating
#16
Do Kyoung Yeon, So Hyun Ki, Jeanne Choi, Sung Min Kang, Woo Kyung Cho
Curry stains on clothes and dishes in daily life inspired us to investigate the potential use of a turmeric powder, major ingredient of curry, as a universal-coating material. After condition optimization, the coating solution was made by boiling and filtering a turmeric slurry, and the coating was performed at pH 3, leading to the formation of ultrathin and transparent films. Various inorganic and polymeric substrates were successfully coated with turmeric-based materials, including gold, TiO2, SiO2, glass, stainless steel, indium tin oxide, nylon, polyethylene, polycarbonate, polypropylene, acryl, and polyethylene terephthalate...
March 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28345895/asymmetric-anchoring-is-required-for-efficient-%C3%AE-loop-opening-and-closing-in-cytosolic-phosphoenolpyruvate-carboxykinase
#17
Danica Cui, Aron Broom, Matthew J Mcleod, Elizabeth M Meiering, Todd Holyoak
Mobile Ω-loops play essential roles in the function of many enzymes. Here we investigated the importance of a residue lying outside of the mobile Ω-loop element in the catalytic function of an H477R variant of cPEPCK using crystallographic, kinetic, and computational analysis. The crystallographic data suggest that efficient transitioning of the Ω-loop to the closed conformation requires stabilization of the N-terminus of the loop through contacts between R461 and E588. In contrast, the C-terminal end of the Ω-loop undergoes changing interactions with the enzyme body through contacts between H477 at the C-terminus of the loop and E591 located on the enzyme body...
March 27, 2017: Biochemistry
https://www.readbyqxmd.com/read/28345879/vibrational-probes-from-small-molecule-solvatochromism-theory-and-experiments-to-applications-in-complex-systems
#18
Bartosz Błasiak, Casey H Londergan, Lauren J Webb, Minhaeng Cho
The vibrational frequency of a chosen normal mode is one of the most accurately measurable spectroscopic properties of molecules in condensed phases. Accordingly, infrared absorption and Raman scattering spectroscopy have provided valuable information on both distributions and ensemble-average values of molecular vibrational frequencies, and these frequencies are now routinely used to investigate structure, conformation, and even absolute configuration of chemical and biological molecules of interest. Recent advancements in coherent time-domain nonlinear vibrational spectroscopy have allowed the study of heterogeneous distributions of local structures and thermally driven ultrafast fluctuations of vibrational frequencies...
March 27, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28345708/evaluation-of-two-and-three-dimensional-electrode-platforms-for-the-electrochemical-characterization-of-organometallic-catalysts-incorporated-in-non-conducting-metal-organic-frameworks
#19
Edgar Mijangos, Souvik Roy, Sonja Pullen, Reiner Lomoth, Sascha Ott
The development of a reliable platform for the electrochemical characterization of a redox-active molecular diiron complex, [FeFe], immobilized in a non-conducting metal organic framework (MOF), UiO-66, based on glassy-carbon electrodes is reported. Voltammetric data with appreciable current responses can be obtained by the use of multiwalled carbon nanotubes (MWCNT) or mesoporous carbon (CB) additives that function as conductive scaffolds to interface the MOF crystals in "three-dimensional" electrodes. In the investigated UiO-66-[FeFe] sample, the low abundance of [FeFe] in the MOF and the intrinsic insulating properties of UiO-66 prevent charge transport through the framework, and consequently, only [FeFe] units that are in direct physical contact with the electrode material are electrochemically addressable...
March 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28345671/spatiotemporal-expression-of-osteopontin-in-the-striatum-of-rats-subjected-to-the-mitochondrial-toxin-3-nitropropionic-acid-correlates-with-microcalcification
#20
Tae-Ryong Riew, Hong Lim Kim, Xuyan Jin, Jeong-Heon Choi, Yoo-Jin Shin, Ji Soo Kim, Mun-Yong Lee
Our aim was to elucidate whether osteopontin (OPN) is involved in the onset of mineralisation and progression of extracellular calcification in striatal lesions due to mitochondrial toxin 3-nitropropionic acid exposure. OPN expression had two different patterns when observed using light microscopy. It was either localised to the Golgi complex in brain macrophages or had a small granular pattern scattered in the affected striatum. OPN labelling tended to increase in number and size over a 2-week period following the lesion...
March 27, 2017: Scientific Reports
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