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Stanniocalcin

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https://www.readbyqxmd.com/read/27878259/stanniocalcin-2-improved-osteoblast-differentiation-via-phosphorylation-of-erk
#1
Juan Zhou, Yinghua Li, Lina Yang, Yougen Wu, Yunjiao Zhou, Yunqing Cui, Gong Yang, Yang Hong
Mammalian stanniocalcin 2 (STC2) is a glycoprotein hormone with multiple functions. The present study determined the importance of STC2 in osteoblast differentiation. It was revealed that the expression of STC2 was increased during the differentiation of MC3T3-E1 cells to osteoblasts and that knockdown of STC2 reduced osteoblast differentiation and mineralization, whereas STC2 overexpression increased differentiation and mineralization. Knockdown of STC2 downregulated the expression of osteoblast-associated genes, including runt‑related transcription factor 2, collagen type I α 1 chain, osterix and osteocalcin...
November 16, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27863406/stc2-promotes-head-and-neck-squamous-cell-carcinoma-metastasis-through-modulating-the-pi3k-akt-snail-signaling
#2
Shuwen Yang, Qinghai Ji, Bin Chang, Yan Wang, Yongxue Zhu, Duanshu Li, Caiping Huang, Yulong Wang, Guohua Sun, Ling Zhang, Qing Guan, Jun Xiang, Wenjun Wei, Zhongwu Lu, Tian Liao, Jiao Meng, Ziliang Wang, Ben Ma, Li Zhou, Yu Wang, Gong Yang
The mammalian peptide hormone stanniocalcin 2 (STC2) plays an oncogenic role in many human cancers. However, the exact function of STC2 in human head and neck squamous cell carcinoma (HNSCC) is unclear. We aimed to examine the function and clinical significance of STC2 in HNSCC. Using in vitro and in vivo assays, we show that overexpression of STC2 suppressed cell apoptosis, promoted cell proliferation, migration, invasion, and cell cycle arrest at the G1/S transition. By contrast, silencing of STC2 inhibited these activities...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27793387/effect-of-pregnancy-associated-plasma-protein-a-papp-a-single-nucleotide-polymorphisms-on-the-level-and-activity-of-papp-a-and-the-hormone-profile-in-fluid-from-normal-human-small-antral-follicles
#3
Jane Alrø Bøtkjær, Tanni Borgbo, Søren Kløverpris, Pernille Rimmer Noer, Claus Oxvig, Claus Yding Andersen
OBJECTIVE: To reveal a possible relationship between two single nucleotide polymorphisms (SNPs) in PAPP-A-1224 (rs7020782) and 327 (rs12375498)-and the level and activity of PAPP-A in follicular fluid (FF) of human small antral follicles, and to analyze the intrafollicular hormone levels. DESIGN: Laboratory investigation. SETTING: University hospital. PATIENT(S): Fifty volunteer women who contributed a total of 210 samples of FF from normal small antral follicles...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27730346/stanniocalcin-1-enhances-carbon-flux-from-glucose-to-lipids-in-white-retroperitoneal-adipose-tissue-in-the-fed-rat
#4
Aline G Cozer, Márcia Trapp, Claudia Vieira Marques, Tiago L Martins, Jorge Felipe A Model, Vanessa Schein, Luiz Carlos Kucharski, Roselis S M Da Silva
The present work assesses in vitro the role of human Stanniocalcin 1 (hSTC-1) in glucose metabolism in white retroperitoneal adipose tissue (WRAT) from fed rat. In the fed state, hSTC1 increases the incorporation of (14)C from glucose into lipids in the rat WRAT. The increase in lipogenesis capacity supports the hypothesis that the activity of the glycerol-3-phosphate-generating pathway (glycolysis) from glucose is regulated by hSTC-1. The effect of hSTC-1 on de novo fatty acid synthesis and on glucose oxidation in WRAT is supported by an 85 % increase in (14)CO2 production from (14)C-glucose...
October 11, 2016: Lipids
https://www.readbyqxmd.com/read/27646979/cerebrospinal-fluid-stanniocalcin-1-as-a-biomarker-for-alzheimer-s-disease-and-other-neurodegenerative-disorders
#5
Pashtun Shahim, Kaj Blennow, Per Johansson, Johan Svensson, Simone Lista, Harald Hampel, Leif Christer Andersson, Henrik Zetterberg
Stanniocalcin-1 (STC-1) is a nerve cell-enriched protein involved in intracellular calcium homeostasis regulation. Changes in calcium regulation are hypothesized to play a role in the pathophysiology of Alzheimer's disease (AD). The expression of STC-1 increases in response to ischemic stroke, but whether it is altered in neurodegenerative disorder, particularly Alzheimer's disease (AD), has not been investigated before. We measured STC-1 in cerebrospinal fluid (CSF) samples from a total of 163 individuals including AD, prodromal AD (pAD), mixed AD, stable mild cognitive impairment (sMCI), and diagnoses of other dementia than AD, as well as cognitively normal controls (CNC) enrolled at academic centers in France and Sweden...
September 19, 2016: Neuromolecular Medicine
https://www.readbyqxmd.com/read/27603899/stanniocalcin-1-hormone-in-non-preeclamptic-and-preeclamptic-pregnancy-clinical-life-style-and-genetic-modulators
#6
Peeter Juhanson, Kristiina Rull, Triin Kikas, Hannele Laivuori, Pille Vaas, Eero Kajantie, Seppo Heinonen, Maris Laan
: Context, Objectives: The study represents the first comprehensive analysis of Stanniocalcin 1 (STC1) hormone in human pregnancy, assessing clinical, life-style and genetic determinants of circulating STC1 at term. DESIGN, SETTING, PARTICIPANTS: Participants included women with (n=50) and without (n=316) preeclampsia (PE) at delivery, recruited in the REPROgrammed fetal and/or maternal METAbolism study (REPROMETA; 2006-2011, Estonia). Genetic association analysis combined PE cases (n=597) and controls (n=623) from the REPROMETA and FINNPEC (the Finnish Genetics of Preeclampsia Consortium; 2008-2011) studies...
September 7, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27560636/effect-of-hypoxia-on-the-expression-of-genes-encoding-insulin-like-growth-factors-and-some-related-proteins-in-u87-glioma-cells-without-ire1-function
#7
Dmytro O Minchenko, A P Kharkova, O V Halkin, L L Karbovskyi, O H Minchenko
OBJECTIVE: The aim of the present study was to investigate the effect of hypoxia on the expression of genes encoding insulin-like growth factors (IGF1 and IGF2), their receptor (IGF1R), binding protein-4 (IGFBP4), and stanniocalcin 2 (STC2) in U87 glioma cells in relation to inhibition of endoplasmic reticulum stress signaling mediated by IRE1 (inositol requiring enzyme 1) for evaluation of their possible significance in the control of tumor growth. METHODS: The expression of IGF1, IGF2, IGF1R, IGFBP4, and STC2 genes in U87 glioma cells transfected by empty vector pcDNA3...
April 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27554927/insights-into-molecular-and-cellular-mechanisms-of-hormonal-actions-on-fish-ion-regulation-derived-from-the-zebrafish-model
#8
Ying-Jey Guh, Pung-Pung Hwang
Fish have sophisticated mechanisms of ionic and acid-base regulation for maintaining body fluid homeostasis. Many hormones have been proposed to control the ionic and acid-base regulation mechanisms in fishes; however, lots of the proposed actions lack convincing cellularr/molecular evidence. With the advantages of available genetic databases and molecular manipulation techniques, zebrafish has become an emerging model for research into ion transport physiology and functional regulation. Different types of ionocytes were found to transport ions through various sets of ion transporters, and the molecular mechanisms of ionocyte proliferation and differentiation have also been dissected, providing a competent platform with which to precisely study the ion transport pathways and ionocytes targeted by hormones, including isotocin, prolactin, cortisol, stanniocalcin-1, calcitonin, endothelin-1, vitamin D, parathyorid hormone 1, catecholamines, the renin-angiotensin-system, estrogen-related receptor α, and calcitonin gene-related peptide, which have been demonstrated to positively or negatively regulate ion transport through specific receptors at different molecular levels (transcriptional, translational, or posttranslational) or at different developmental stages of ionocytes (proliferation or differentiation)...
August 20, 2016: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27469269/stanniocalcin-1-attenuates-ischemic-cardiac-injury-and-response-of-differentiating-monocytes-macrophages-to-inflammatory-stimuli
#9
Arezoo Mohammadipoor, Ryang Hwa Lee, Darwin J Prockop, Thomas J Bartosh
Stanniocalcin-1 (STC-1) is a multifunctional glycoprotein with antioxidant and anti-inflammatory properties. Ischemic myocardial necrosis generates "danger" signals that perpetuate detrimental inflammatory reactions often involving monocyte recruitment and their subsequent differentiation into proinflammatory macrophages. Therefore, we evaluated the effects of recombinant STC-1 (rSTC-1) on monocyte phenotype and in a mouse model of myocardial infarction. Using an established protocol to differentiate human monocytes into macrophages, we demonstrated that rSTC-1 did not alter morphology of the differentiated cells, toll-like receptor (TLR) 4 expression, or expression of the myeloid cell marker CD11b...
November 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27461417/stc-1-expression-is-upregulated-through-an-akt-nf-%C3%AE%C2%BAb-dependent-pathway-in-triple-negative-breast-cancer-cells
#10
Myeongjin Jeon, Jeonghun Han, Seok Jin Nam, Jeong Eon Lee, Sangmin Kim
Stanniocalcin-1 (STC-1) is a secreted glycoprotein and its expression is strongly correlated with cancer development. However, regulatory mechanism of STC-1 expression in breast cancer cells is not clear. In the present study, we investigated whether STC-1 acts as a prognostic factor in TNBC patients and the regulation of STC-1 expression in breast cancer cells. Basal levels of STC-1 were significantly higher in TNBC cells than in non-TNBC cells. Induction of STC-1 expression was also associated with poor relapse-free survival of TNBC patients...
September 2016: Oncology Reports
https://www.readbyqxmd.com/read/27459971/elevated-stc%C3%A2-1-augments-the-invasiveness-of-triple%C3%A2-negative-breast-cancer-cells-through-activation-of-the-jnk-c%C3%A2-jun-signaling-pathway
#11
Jeonghun Han, Myeongjin Jeon, Incheol Shin, Sangmin Kim
Stanniocalcin‑1 (STC‑1), a secreted glycoprotein, is highly expressed in a variety of human malignancies. However, the role of STC‑1 has not been fully elucidated in breast cancer cells. Here, we investigated whether STC‑1 acts as a prognostic factor in triple‑negative breast cancer (TNBC) patients, and we explored the cellular mechanism in breast cancer cells. The level of STC‑1 expression was directly associated with the relapse‑free and overall survival of basal‑type breast cancer patients...
September 2016: Oncology Reports
https://www.readbyqxmd.com/read/27437760/effect-of-vitamin-k-in-bone-metabolism-and-vascular-calcification-a-review-of-mechanisms-of-action-and-evidences
#12
Julia Khéde Dourado Villa, Marisa Alves Nogueira Diaz, Virgínia Ramos Pizziolo, Hércia Stampini Duarte Martino
Osteoporosis is a public health concern associated with an increased risk of bone fractures and vascular calcification. Vitamin K presents unique benefits on these issues, although understudied. The two main forms of vitamin K are phylloquinone (vitamin K1) and menaquinone (vitamin K2). In this study, it was especially investigated the action of vitamin K2 in bones and vessels. Vitamin K2 has shown to stimulate bone formation by promoting osteoblast differentiation and carboxylation of osteocalcin, and increasing alkaline phosphatase, insulin-like growth factor-1, growth differentiation factor-15, and stanniocalcin 2 levels...
July 20, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27420048/stanniocalcin-1-protects-a-mouse-model-from-renal-ischemia-reperfusion-injury-by-affecting-ros-mediated-multiple-signaling-pathways
#13
Dajun Liu, Huiping Shang, Ying Liu
Stanniocalcin-1 (STC-1) protects against renal ischemia-reperfusion injury (RIRI). However, the molecular mechanisms remain widely unknown. STC-1 inhibits reactive oxygen species (ROS), whereas most ROS-mediated pathways are associated with ischemic injury. Therefore, to explore the mechanism, the effects of STC-1 on ROS-medicated pathways were studied. Non-traumatic vascular clamps were used to establish RIRI mouse models. The serum levels of STC-1, interleukin-6 (IL-6), interferon (IFN) γ, P53, and capase-3 were measured by ELISA kits...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27409607/regulation-of-intestinal-epithelial-calcium-transport-proteins-by-stanniocalcin-1-in-caco2-cells
#14
Jinmei Xiang, Rui Guo, Chunyun Wan, Liming Wu, Shijin Yang, Dingzong Guo
Stanniocalcin-1 (STC1) is a calcium and phosphate regulatory hormone. However, the exact molecular mechanisms underlying how STC1 affects Ca(2+) uptake remain unclear. Here, the expression levels of the calcium transport proteins involved in transcellular transport in Caco2 cells were examined following over-expression or inhibition of STC1. These proteins include the transient receptor potential vanilloid members (TRPV) 5 and 6, the plasma membrane calcium ATPase 1b (PMCA1b), the sodium/calcium exchanger (NCX1), and the vitamin D receptor (VDR)...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27346255/contrasting-effects-of-stanniocalcin-related-polypeptides-on-macrophage-foam-cell-formation-and-vascular-smooth-muscle-cell-migration
#15
Keigo Yamamoto, Yukie Tajima, Akinori Hasegawa, Yui Takahashi, Miho Kojima, Rena Watanabe, Kengo Sato, Masayoshi Shichiri, Takuya Watanabe
Stanniocalcin (STC) is a calcium- and phosphate-regulating hormone secreted by the corpuscles of Stannius, an endocrine gland of bony fish. Its human homologues, STC1 and STC2 showing 34% amino acid identity each other, are expressed in a variety of human tissues. To clarify their roles in atherosclerosis, we investigated the effects of their full-length proteins, STC1(18-247) and STC2(25-302), and STC2-derived fragment peptides, STC2(80-100) and STC2(85-99), on inflammatory responses in human umbilical vein endothelial cells (HUVECs), human macrophage foam cell formation, the migration and proliferation of human aortic smooth muscle cells (HASMCs) and the extracellular matrix expression...
August 2016: Peptides
https://www.readbyqxmd.com/read/27322879/stanniocalcin-1-expression-in-normal-human-endometrium-and-dysregulation-in-endometriosis
#16
Lusine Aghajanova, Signe Altmäe, Sergo Kasvandik, Andres Salumets, Anneli Stavreus-Evers, Linda C Giudice
OBJECTIVE: To determine expression of stanniocalcin-1 (STC1) in human endometrium with and without endometriosis and its regulation by steroid hormones. DESIGN: Laboratory study. SETTING: University. PATIENT(S): Nineteen women with endometriosis and 33 control women. INTERVENTION(S): Endometrial biopsy and fluid sampling. MAIN OUTCOME MEASURE(S): Analysis of early secretory (ESE) and midsecretory (MSE) endometrial secretomes from fertile women with the use of nano-liquid chromatography-dual mass spectrometry; real-time quantitative polymerase chain reaction, and immunohistochemistry for STC1 and its receptor calcium-sensing receptor (CASR) mRNA and proteins in endometrium with and without endometriosis; evaluation of STC1 and CASR mRNA expression in endometrial stromal fibroblasts (eSF) from women with and without endometriosis decidualized with the use of E2P or 8-bromo-cyclic adenosine monophosphate (cAMP)...
September 1, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27245421/stanniocalcin-2-induces-oxaliplatin-resistance-in-colorectal-cancer-cells-by-upregulating-p-glycoprotein
#17
Qiong Yuan, Lin Zhan, Li-Li Zhang, Qiang Wang, Juan Liu, Zhen-Yu Jiang, Xia-Min Hu, Xin-Chu Yuan
Multidrug resistance (MDR) limits the anticancer effects of chemotherapy in patients with metastatic colorectal cancer (CRC). Oxaliplatin is a common component of combinational therapeutic regimens administered to patients with metastatic CRC; however, it is also used as a constituent of adjuvant therapy for patients at a risk of recurrent disease. In the present study, we investigated the role of stanniocalcin 2 (STC2) in chemoresistance. STC2 knockdown sensitized chemoresistant CRC cells to oxaliplatin. Moreover, the expression of exogenous STC2 in chemonaïve CRC cells induced oxaliplatin resistance...
September 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27156337/stc1-and-nf-%C3%AE%C2%BAb-p65-rel-a-is-constitutively-activated-in-colorectal-cancer
#18
Saleheh Rezapour, Tayyeb Bahrami, Shahryar Hashemzadeh, Mehrdad Asghari Estiar, Masoumeh Nemati, Reyhaneh Ravanbakhsh, Mohammad Ali Hosseinpour Feizi, Hossein Samadi Kafil, Nasser Pouladi, Morteza Ghojazadeh, Ebrahim Sakhinia
BACKGROUND: Stanniocalcin-1 (STC1) and nuclear factor (NF)-κB subunit p65 transcription factor are involved in various types of human malignancies. The roles of STC1 and NFκB-p65 in colorectal cancer (CRC) are still not fully understood. We investigated expression levels of NF-κB p65 and STC1 and also correlations between STC1 and NF-κB p65 expression and clinicopathological features in CRC. METHODS: Tumor tissue samples were collected from 48 patients with CRC...
2016: Clinical Laboratory
https://www.readbyqxmd.com/read/27155776/papp-a-and-the-igf-system
#19
Philippe Monget, Claus Oxvig
Firstly discovered as a placental protein present abundantly in the circulation of pregnant women, pregnancy-associated plasma protein-A (PAPP-A) is widely expressed in multiple tissues. PAPP-A is a metalloproteinase that is able to specifically cleave three insulin-like growth factor binding proteins (IGFBPs): IGFBP-2, -4 and -5. PAPP-A binds tightly to glycosaminoglycans present on the surface of cells, thus functioning within tissues as a growth-promoting enzyme, releasing bioactive IGF in close proximity to the IGF receptor...
June 2016: Annales D'endocrinologie
https://www.readbyqxmd.com/read/27141097/a-contra-capture-protein-array-platform-for-studying-post-translationally-modified-ptm-auto-antigenomes
#20
Kailash Karthikeyan, Kristi Barker, Yanyang Tang, Peter Kahn, Peter Wiktor, Al Brunner, Vinicius Knabben, Bharath Takulapalli, Jane Buckner, Gerald Nepom, Joshua LaBaer, Ji Qiu
Aberrant modifications of proteins occur during disease development and elicit disease-specific antibody responses. We have developed a protein array platform that enables the modification of many proteins in parallel and assesses their immunogenicity without the need to express, purify, and modify proteins individually. We used anticitrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) as a model modification and profiled antibody responses to ∼190 citrullinated proteins in 20 RA patients...
July 2016: Molecular & Cellular Proteomics: MCP
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