Hilda Björk Daníelsdóttir, Thor Aspelund, Qing Shen, Thorhildur Halldorsdottir, Jóhanna Jakobsdóttir, Huan Song, Donghao Lu, Ralf Kuja-Halkola, Henrik Larsson, Katja Fall, Patrik K E Magnusson, Fang Fang, Jacob Bergstedt, Unnur Anna Valdimarsdóttir
IMPORTANCE: Exposure to adverse childhood experiences (ACEs) has consistently been associated with multiple negative mental health outcomes extending into adulthood. However, given that ACEs and psychiatric disorders cluster within families, it remains to be comprehensively assessed to what extent familial confounding contributes to associations between ACEs and clinically confirmed adult psychiatric disorders. OBJECTIVE: To investigate whether associations between ACEs and adult mental health outcomes remain after adjusting for familial (genetic and environmental) confounding...
March 6, 2024: JAMA Psychiatry