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Type 1 diabetes paediatric

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https://www.readbyqxmd.com/read/28242271/incidence-of-and-risk-factors-for-hospitalisations-due-to-vascular-complications-a-population-based-type-1-diabetes-cohort-n-1316-followed-into-early-adulthood
#1
Matthew N Cooper, Martin I de Bock, Kim W Carter, Nicholas H de Klerk, Timothy W Jones, Elizabeth A Davis
AIM: To determine the incidence of hospitalisations and risk factors for vascular complications experienced during early adulthood in patients with childhood onset type 1 diabetes. METHODS: A population-based childhood onset type 1 diabetes cohort was identified from a statewide register (1992-2012). Data linkage was used to identify a matched comparison cohort. Hospital admissions data were extracted to follow up both cohorts into early adulthood (1975-2012). RESULTS: The type 1 diabetes cohort (n=1316) had a mean age of diagnosis of 9...
January 20, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28239881/how-chronic-disease-affects-children-s-views-on-being-ill-and-healthy-a-comparative-study
#2
Lígia Lima, Vanessa Silva, Marina S Lemos
BACKGROUND: Understanding children's views of illness and health is vital to a child-centred approach in patient education and care. Paediatric healthcare providers should incorporate children's views of health and illness to enable children and their families to participate in self-management plans and achieve better health outcomes. However, there is limited scientific knowledge regarding the views of children with specific diseases. METHOD: This comparative study investigated whether and in what ways the experience of having different chronic diseases influenced children's views of being ill and healthy...
February 26, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28213828/screening-for-non-alcoholic-fatty-liver-disease-in-children-and-adolescents-with-type-1-diabetes-mellitus-a-cross-sectional-analysis
#3
Sebastian Kummer, Dirk Klee, Gerald Kircheis, Michael Friedt, Joerg Schaper, Dieter Häussinger, Ertan Mayatepek, Thomas Meissner
The liver is intensely involved in glucose metabolism and is thereby closely related to diabetes pathophysiology. Adult patients with type 1 diabetes mellitus (DM) are at an increased risk for non-alcoholic fatty liver disease (NAFLD). Here, we studied the prevalence of NAFLD in a cohort of children and adolescents with type 1 DM in a tertiary care paediatric diabetes centre in Germany. We screened 93 children and adolescents with type 1 DM using ultrasound, laboratory investigations, and liver stiffness measurements (Fibroscan® [FS] and acoustic radiation force imaging [ARFI])...
February 17, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28208043/the-australasian-diabetes-data-network-first-national-audit-of-children-and-adolescents-with-type-1-diabetes
#4
Helen Phelan, Helen Clapin, Loren Bruns, Fergus J Cameron, Andrew M Cotterill, Jennifer J Couper, Elizabeth A Davis, Kim C Donaghue, Craig A Jefferies, Bruce R King, Richard O Sinnott, Elaine B Tham, Jerry K Wales, Timothy W Jones, Maria E Craig
OBJECTIVES: To assess glycaemic control, anthropometry and insulin regimens in a national sample of Australian children and adolescents with type 1 diabetes. DESIGN: Cross-sectional analysis of de-identified, prospectively collected data from the Australasian Diabetes Data Network (ADDN) registry. SETTING: Five paediatric diabetes centres in New South Wales, Queensland, South Australia, Victoria and Western Australia. PARTICIPANTS: Children and adolescents (aged 18 years or under) with type 1 diabetes of at least 12 months' duration for whom data were added to the ADDN registry during 2015...
February 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28185422/the-association-of-the-hla-a-24-02-b-39-01-and-b-39-06-alleles-with-type-1-diabetes-is-restricted-to-specific-hla-dr-dq-haplotypes-in-finns
#5
M-L Mikk, T Heikkinen, M I El-Amir, M Kiviniemi, A-P Laine, T Härkönen, R Veijola, J Toppari, M Knip, J Ilonen
BACKGROUND: We analysed the previously reported association of the HLA-A*24:02, B*18 and B*39 alleles with type 1 diabetes and diabetes associated autoimmunity in the Finnish population applying HLA-DR/DQ stratification. MATERIALS & METHODS: Haplotype transmission was analysed in 2424 nuclear families from the Finnish Paediatric Diabetes Register. Survival analysis was applied to study the development of islet autoantibodies and further progression to clinical diabetes in the prospective follow-up cohort from the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Study...
April 2017: HLA
https://www.readbyqxmd.com/read/28164370/impact-of-neighbourhood-level-inequity-on-paediatric-diabetes-care
#6
A B M Clarke, D Daneman, J R Curtis, F H Mahmud
AIMS: To evaluate the association between neighbourhood-level inequity and glycaemic control in paediatric participants with Type 1 diabetes using the Neighbourhood Equity Index (NEI). METHODS: The NEI was linked to the clinical data of 519 children with diabetes followed at the Hospital for Sick Children (Toronto, Canada). The NEI is a composite measure of inequity developed using the World Health Organization's Urban Health Equity Assessment and Response Tool (HEART), which encompasses 15 weighted indicators evaluating economic, social, environmental and lifestyle factors...
February 6, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28146141/type-1-diabetes-from-adolescence-to-adulthood-is-there-a-permanent-need-for-nutrition-education-and-reeducation
#7
Maja Baretić, Martina Matovinović Osvatić, Eva Pavić, Nada Rabađija, Valentina Uroić, Carolina Koletić, Nataša Rojnić Putarek, Ivana Pavlić Renar
BACKGROUND: The transition for type 1 diabetes patients from paediatric to adult diabetology care is challenging process for both medical team and patients. Adult diabetology usually insists on stricter goals and focuses on increased empowerment and self-care. We set to find a more practical and effective way to determine patient knowledge and skills during the transition. The aim of the study was to identify screening questions which best represent knowledge in management of type 1 diabetes and to explore the differences in the effect of a structured educational program for type 1 diabetes patient diagnosed in childhood versus adulthood...
January 31, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28144991/hypercholesterolaemia-screening-in-type-1-diabetes-a-difference-of-opinion
#8
T Candler, O Mahmoud, J Edge, J Hamilton Shield
AIM: To assess cholesterol screening of children with Type 1 diabetes by diabetes professionals using a survey of current practice, given that National Institute of Health and Care Excellence guidelines on childhood Type 1 diabetes do not recommend cholesterol screening, yet the National Paediatric Diabetes Audit has an annual cholesterol measure (>12 years) as a key outcome indicator. METHODS: An online survey was sent to 280 members of the Association of Children's Diabetes Clinicians to assess cholesterol screening practice in children...
February 1, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28137708/an-alternative-sensor-based-method-for-glucose-monitoring-in-children-and-young-people-with-diabetes
#9
Julie Edge, Carlo Acerini, Fiona Campbell, Julian Hamilton-Shield, Chris Moudiotis, Shakeel Rahman, Tabitha Randell, Anne Smith, Nicola Trevelyan
OBJECTIVE: To determine accuracy, safety and acceptability of the FreeStyle Libre Flash Glucose Monitoring System in the paediatric population. DESIGN, SETTING AND PATIENTS: Eighty-nine study participants, aged 4-17 years, with type 1 diabetes were enrolled across 9 diabetes centres in the UK. A factory calibrated sensor was inserted on the back of the upper arm and used for up to 14 days. Sensor glucose measurements were compared with capillary blood glucose (BG) measurements...
January 30, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28132100/towards-a-systematic-nationwide-screening-strategy-for-mody
#10
EDITORIAL
Beverley Shields, Kevin Colclough
MODY is an early-onset monogenic form of diabetes. Correctly identifying MODY is of considerable importance as diagnosing the specific genetic subtype can inform the optimal treatment, with many patients being able to discontinue unnecessary insulin treatment. Diagnostic molecular genetic testing to confirm MODY is expensive, so screening strategies are required to identify the most appropriate patients for testing. In this issue of Diabetologia, Johansson and colleagues (DOI 10.1007/s00125-016-4167-1 ) describe a nationwide systematic screening approach to identify individuals with MODY in the paediatric age range...
January 29, 2017: Diabetologia
https://www.readbyqxmd.com/read/28099760/clinical-behavioural-and-social-indicators-for-poor-glycaemic-control-around-the-time-of-transfer-to-adult-care-a-longitudinal-study-of-126-young-people-with-diabetes
#11
P Castensøe-Seidenfaden, A K Jensen, H Smedegaard, E Hommel, G R Husted, U Pedersen-Bjergaard, G Teilmann
AIMS: To describe and compare changes in glycaemic control in young people with Type 1 diabetes over time between the last 2 years in paediatric care and the first 2 years in adult care and to identify risk factors for poor glycaemic control. METHODS: Our retrospective cohort study followed participants aged 14-22 years from 2 years before to 2 years after transfer from paediatric to adult care. Changes in glycaemic control were calculated using repeated measurements...
January 18, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28065736/long-term-outcomes-of-bariatric-surgery-in-adolescents-with-severe-obesity-fabs-5-a-prospective-follow-up-analysis
#12
Thomas H Inge, Todd M Jenkins, Stavra A Xanthakos, John B Dixon, Stephen R Daniels, Meg H Zeller, Michael A Helmrath
BACKGROUND: Little is known about the long-term outcomes of bariatric surgery for severe adolescent obesity, raising questions about the durability of early responses to surgery. We aimed to analyse long-term (>5 years) outcomes of Roux-en-Y gastric bypass in a cohort of young adults who had undergone the operation during adolescence, in the Follow-up of Adolescent Bariatric Surgery at 5 Plus Years (FABS-5+) extension study. METHODS: A cohort of young people aged 13-21 years underwent Roux-en-Y gastric bypass for clinically severe obesity at a paediatric academic medical centre in the USA...
March 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28065734/laparoscopic-roux-en-y-gastric-bypass-in-adolescents-with-severe-obesity-amos-a-prospective-5-year-swedish-nationwide-study
#13
Torsten Olbers, Andrew J Beamish, Eva Gronowitz, Carl-Erik Flodmark, Jovanna Dahlgren, Gustaf Bruze, Kerstin Ekbom, Peter Friberg, Gunnar Göthberg, Kajsa Järvholm, Jan Karlsson, Staffan Mårild, Martin Neovius, Markku Peltonen, Claude Marcus
BACKGROUND: Severe obesity in adolescence is associated with reduced life expectancy and impaired quality of life. Long-term benefits of conservative treatments in adolescents are known to be modest, whereas short-term outcomes of adolescent bariatric surgery are promising. We aimed to compare 5-year outcomes of adolescent surgical patients after Roux-en-Y gastric bypass with those of conservatively treated adolescents and of adults undergoing Roux-en-Y gastric bypass, in the Adolescent Morbid Obesity Surgery (AMOS) study...
March 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28039141/genotyping-of-coeliac-specific-human-leucocyte-antigen-in-children-with-type-1-diabetes-does-this-screening-method-make-sense
#14
Elisabeth Binder, Martina Loinger, Annelies Mühlbacher, Michael Edlinger, Elisabeth Steichen, Dagmar Meraner, Lorin Loacker, Guenter Weigel, Thomas Müller, Elke Fröhlich-Reiterer, Sabine E Hofer
OBJECTIVES: Due to a high linkage disequilibrium of diabetes and coeliac-specific human leucocyte antigen (HLA) genotypes, the prevalence of coeliac disease (CD) in children and adolescents with diabetes mellitus type 1 (T1D) is much higher than in the general population. Recently, the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) revised new screening guidelines in which genotyping for coeliac-specific HLA alleles is recommended for high-risk patients as patients with T1D...
December 30, 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27973688/paediatric-parenting-stress-in-fathers-and-mothers-of-young-children-with-type%C3%A2-1-diabetes-a-longitudinal-study
#15
A Nieuwesteeg, E Hartman, W Emons, H van Bakel, H-J Aanstoot, E van Mil, F Pouwer
AIM: To compare levels of paediatric parenting stress in the fathers and mothers of young children with Type 1 diabetes and study the variation in this stress over time. METHODS: One hundred and twelve parents (56 mothers and 56 fathers) of young children (0-7 years) with Type 1 diabetes participated in this study. They completed the Pediatric Inventory for Parents to assess paediatric parenting stress (frequency and difficulty scores on the Communication, Emotional Distress, Medical Care and Role Functioning subscales and Total Score); 44 mothers (79%) and 31 fathers (55%) completed the questionnaire again, 1 year later...
December 14, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27931254/feasibility-of-an-online-intervention-stak-d-to-promote-physical-activity-in-children-with-type-1-diabetes-protocol-for-a-randomised-controlled-trial
#16
Holly Blake, Helen Quirk, Paul Leighton, Tabitha Randell, James Greening, Boliang Guo, Cris Glazebrook
BACKGROUND: Regular physical activity has important health benefits for children with type 1 diabetes mellitus (T1DM), yet children and their parents face barriers to participation such as lack of self-efficacy or concerns around hypoglycaemia. Multimedia interventions are useful for educating children about their health and demonstrate potential to improve children's health-related self-efficacy, but few paediatric clinics offer web-based resources as part of routine care. The Steps to Active Kids with Diabetes (STAK-D) programme is an online intervention grounded in psychological theory (social cognitive theory) and informed by extensive preliminary research...
December 8, 2016: Trials
https://www.readbyqxmd.com/read/27927116/the-nurse-s-role-in-childhood-diabetes
#17
Daniel Allen
Essential facts The National Institute for Health and Care Excellence (NICE) has published a quality standard on diabetes in children and young people. NICE quality standards describe high-priority areas for improvement and consist of specific, measurable statements designed to achieve better care. Diabetes is becoming more common in the UK. The latest National Paediatric Diabetes Audit says the number of children and young people cared for in children's diabetes units is rising by 4% per year. In 2014-15, the prevalence in England and Wales of type 1 diabetes in those aged 15 and under was 192 per 100,000 of the general population, with slightly more males affected than females...
December 8, 2016: Nursing Children and Young People
https://www.readbyqxmd.com/read/27887605/a-randomised-open-labelstudy-of-insulin-glargine-or-neutral-protamine-hagedorn-insulin-in-chinese-paediatric-patients-with-type-1-diabetes-mellitus
#18
RANDOMIZED CONTROLLED TRIAL
Min Liu, Zhiguang Zhou, Jinhua Yan, Pin Li, Wenhui Song, Junfen Fu, Xiaobo Chen, Weigang Zhao, Li Xi, Xiaoping Luo, Liang Sha, Xueyuan Deng, Chunxiu Gong
BACKGROUND: We aimed to describe the safety and efficacy of insulin glargine in Chinese paediatric patients with type 1 diabetes mellitus (T1DM). Neutral protamine Hagedorn (NPH) insulin was the reference therapy. METHODS: This open-label, randomised, Phase III study was conducted at 10 sites in China. Children aged ≥6 to <18 years with T1DM were randomised (2:1) to insulin glargine or NPH insulin asbasal insulinfor a 24-week treatment period. For all patients, insulin aspart was given as bolus insulin...
November 26, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27885706/insulin-pump-failures-in-italian-children-with-type%C3%A2-1-diabetes-retrospective-1-year-cohort-study
#19
I Rabbone, N Minuto, R Bonfanti, M Marigliano, F Cerutti, V Cherubini, G d'Annunzio, A Frongia, D Iafusco, G Ignaccolo, F Lombardo, R Schiaffini, S Toni, S Tumini, S Zucchini, A Pistorio, A E Scaramuzza
AIMS: Insulin pump failure and/or malfunction requiring replacement have not been thoroughly investigated. This study evaluated pump replacement in children and adolescents with Type 1 diabetes using insulin pump therapy. METHODS: Data were collected for all participants younger than 19 years, starting insulin pump therapy before 31 December 2013. For each child, age, disease duration, date of insulin pump therapy initiation, insulin pump model, failure/malfunction/replacement yes/no and reason were considered for the year 2013...
November 25, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27878933/psychiatric-disorders-during-early-adulthood-in-those-with-childhood-onset-type-1-diabetes-rates-and-clinical-risk-factors-from-population-based-follow-up
#20
M N Cooper, A Lin, G A Alvares, N H de Klerk, T W Jones, E A Davis
AIM: To determine the incidence of and risk factors for psychiatric disorders in early adulthood in patients with childhood onset type 1 diabetes (T1D). METHODS: In this retrospective-cohort study, we identified a population-based childhood onset T1D cohort and an age and sex matched (5:1) non-diabetic comparison cohort. Data linkage was used to access inpatient hospitalization data, mental health support service data, and mortality data to follow-up both cohorts into early adulthood...
November 23, 2016: Pediatric Diabetes
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