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https://www.readbyqxmd.com/read/30214511/application-of-karyotype-analysis-combined-with-bacs-on-beads-for-prenatal-diagnosis
#1
Yuan Fang, Guangming Wang, Lize Gu, Jingjing Wang, Feng Suo, Maosheng Gu, Lingshan Gou
This study explored the clinical application of karyotype analysis combined with BACs-on-Beads (BoBs) technology in prenatal diagnosis. A total of 558 pregnant women who were admitted to Xuzhou Maternity and Child Health Care Hospital from July 2015 to June 2017 were enrolled in this study. All the subjects underwent amniocentesis. BoBs assay was performed for subjects in the observation group, and karyotype analysis was performed for subjects in the control group. The main technical indicators of subjects in the two groups were summarized, and cases of chromosome abnormalities were further evaluated...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30214509/effect-of-abnormal-gpg-methylation-in-the-second-trimester-of-pregnancy-on-adverse-health-risk-of-offspring
#2
Yu Shi, Mingxing Liu, Xiaolin Long, Dunjin Chen, Haiyan Zheng, Shiling Chen
Effect of abnormal GpG methylation in amniotic fluid cells during the second trimester of pregnancy on adverse health risk of offspring was investigated. In total, 237 sets of amniotic fluid cells were collected from patients who received prenatal diagnosis in the Third Affiliated Hospital of Guangzhou Medical University (Guangzhou, China) from April 2010 to October 2011. Among them, 156 sets were from singleton and 81 sets were from twins. H19 gene was amplified by PCR, and the product was purified and pyrosequencing was used to detect the DNA methylation level of GapG...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30213573/management-of-antenatally-detected-kidney-malformations
#3
Angela Yulia, Paul Winyard
Congenital anomalies of the kidneys and the urinary tract (CAKUT) are one of the most common sonographically identified antenatal malformations. Dilatation of the renal pelvis accounts for the majority of cases, but this is usually mild rather than an indicator of obstructive uropathy. Other conditions such as small through large hyperechogenic and/or cystic kidneys present a significant diagnostic dilemma on routine scanning. Accurate diagnosis and prediction of prognosis is often not possible without a positive family history, although maintenance of adequate amniotic fluid is usually a good sign...
September 10, 2018: Early Human Development
https://www.readbyqxmd.com/read/30213462/desirable-quality-control-materials-for-the-establishment-of-qualified-external-quality-assessment-on-prenatal-diagnosis-of-chromosomal-aneuploidies
#4
Yuchan Mao, Lan Su, Hongge Li, Yanmei Yang, Binghuan Weng
OBJECTIVE: To prepare desirable quality-control materials for the establishement of qualified external quality assessment on fluorescence in situ hybridization (FISH)-detected prenatal diagnosis of chromosomal aneuploidies. METHODS: Four types of amniotic fluid cell suspensions (13-trisomy, 18-trisomy, 21-trisomy and 47,XXY) were mixed together by ratio to produce mosaicism with the percentages of each aneuploidy as 10%, 20%, 30% and 40%, respectively. After being stored in liquid nitrogen of -196 °C for six months, randomly selected samples were incubated in 37 °C water, followed by cultivation, hypo-osmosis and fixation...
September 10, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/30210631/exosome-related-tumor-microenvironment
#5
REVIEW
Cheng Hu, Meijuan Chen, Rilei Jiang, Yuanyuan Guo, Mianhua Wu, Xu Zhang
The tumor microenvironment (tumor cells are located in the internal and external environment) is vital for the occurrence, growth and metastasis of tumors. An increasing number of studies have shown that exosomes are closely related to the tumor microenvironment. The mechanisms involved, however, are unclear. The focus of this review is on the exosome-related tumor microenvironment and other relevant factors, such as hypoxia, inflammation and angiogenesis. Many studies have suggested that exosomes are important mediators of metastasis, angiogenesis, and immune modulation in the tumor microenvironment...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/30209654/human-somatic-stem-cell-neural-differentiation-potential
#6
David J Eve, Paul R Sanberg, Leonora Buzanska, Anna Sarnowska, Krystyna Domanska-Janik
Human somatic stem cells can be identified and isolated from different types of tissues and are grouped here based on their developmental maturation and ability to undergo neural differentiation. The first group will represent afterbirth somatic tissues, which are perinatal stem cells including placental blood and tissue, amniotic fluid and tissue, and umbilical cord blood- and umbilical cord tissue-derived cells. The second group of cells discussed in this chapter is the adult stem cells, generally those in a transient period of development, thus placing them in the special position of transitioning from the perinatal to young somatic tissue, and they include the menstrual blood-, the peripheral blood-, and the bone marrow-derived stem cells...
2018: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/30207805/fetal-and-placental-pathology-in-congenital-syphilis-a-comprehensive-study-in-perinatal-autopsy
#7
Napaputch Kittipornpechdee, Suchanan Hanamornroongruang, Duanphen Lekmak, Jitsupa Treetipsatit
INTRODUCTION: At autopsy, without available serologic information, diagnosing congenital syphilis (CS) relies on identification of Treponema pallidum in tissues. Recognition of clues leading to detection of the organism is important. MATERIALS AND METHODS: Autopsy cases with CS were studied for fetal and placental abnormalities. RESULTS: Twenty-one cases were recruited: 12/21 with identifiable T. pallidum and 9/21 with positive serology and characteristics of CS...
September 12, 2018: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/30207389/urine-biochemistry-to-predict-long-term-outcomes-in-fetuses-with-posterior-urethral-valves
#8
Sophie Dreux, Jonathan Rosenblatt, Amélie Moussy-Durandy, Franck Patin, Romain Favre, Stephen Lortat-Jacob, Alaa El Ghoneimi, Jean-François Oury, Georges Deschenes, Yves Ville, Laurence Heidet, Francoise Muller
OBJECTIVE: Because the literature on the predictive value of fetal urinalysis is controversial in fetuses with lower urinary tract obstruction, we determined the best model of fetal urine biochemical markers correlated with long-term postnatal renal function based on glomerular filtration rate (GFR). METHOD: This retrospective study concerned 89 fetuses with lower urinary tract obstruction and their renal function after 10 years of age. We correlated fetal urine biochemical markers (total protein, β2-microglobulin, sodium, chloride, glucose, calcium, phosphorus) with GFR at 10-30 years of age in 89 patients with posterior urethral valves...
September 12, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/30196733/the-association-between-selected-mid-trimester-amniotic-fluid-candidate-proteins-and-spontaneous-preterm-delivery
#9
Maria Hallingström, Teresa Cobo, Marian Kacerovsky, Kristin Skogstrand, David M Hougaard, Rose-Marie Holst, Panagiotis Tsiartas, Maria Bullarbo, Ylva Carlsson, Staffan Nilsson, Bo Jacobsson
OBJECTIVE: The aim of this study was to explore inflammatory response and identify early potential biomarkers in mid-trimester amniotic fluid associated with subsequent spontaneous preterm delivery (PTD). METHODS: A cohort study was performed at Sahlgrenska University Hospital/Östra, Gothenburg, Sweden, between 2008 and 2010. Amniotic fluid was collected from consecutive women undergoing mid-trimester transabdominal genetic amniocentesis at 14-19 gestational weeks...
September 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30192884/determinants-of-birth-asphyxia-among-live-birth-newborns-in-university-of-gondar-referral-hospital-northwest-ethiopia-a-case-control-study
#10
Lisanu Wosenu, Abebaw Gebeyehu Worku, Destaw Fetene Teshome, Abebaw Addis Gelagay
BACKGROUND: Birth asphyxia, which accounts for 31.6% of all neonatal deaths, is one of the leading causes of such mortality in Ethiopia. Early recognition and management of its contributing factors would modify the problem. Thus, this study aimed to identify the determinants of birth asphyxia among live births at the University of Gondar Referral Hospital, northwest Ethiopia. METHODS: A hospital-based unmatched case-control study was conducted from April to July 2017...
2018: PloS One
https://www.readbyqxmd.com/read/30187503/unexpected-finding-of-uniparental-disomy-mosaicism-in-term-placentas-is-it-a-common-feature-in-trisomic-placentas
#11
Diane Van Opstal, Karin E M Diderich, Marieke Joosten, Lutgarde C P Govaerts, Joke Polak, Marjan Boter, Jasper J Saris, Wai Yee Cheung, Stefanie van Veen, Robert van de Helm, Attie T J I Go, Maarten F C M Knapen, Dimitri N M Papatsonis, Anneke Dijkman, Femke de Vries, R-J H Galjaard, Lies H Hoefsloot, Malgorzata I Srebniak
OBJECTIVE: Non-invasive prenatal testing (NIPT) detects placental chromosome aberrations. When amniocentesis reveals a normal karyotype, confined placental mosaicism (CPM) may be assumed. In order to confirm this, placental cytogenetic studies were performed. METHOD: NIPT was conducted in the course of the Dutch TRIDENT study. Placentas of 10 cases with NIPT results indicating an autosomal trisomy and showing a normal (N=9) or low mosaic karyotype (N=1) in amniotic fluid (AF), were investigated...
September 6, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/30186710/early-accreta-and-uterine-rupture-in-the-second-trimester
#12
Joshua A Ronen, Krystal Castaneda, Sara Y Sadre
The differential diagnosis of third trimester bleeding can range from placenta abruptia to placenta previa to uterine rupture and the placenta accreta spectrum (PAS). However, patients with risk factors such as multiple cesarean sections (c-sections), advanced maternal age (AMA), grand multiparity, and single-layer uterine closure are at greater risk of developing these complications earlier than we would traditionally expect. This case recounts a 38-year-old gravida 6 preterm 3 term 1 abortus 1 live 4 (G6P3114) at 23 weeks and five days gestational age (GA) with a past medical history of preterm pregnancy, pre-eclampsia, chronic abruptia, three previous c-sections, and low-lying placenta who presented to the emergency department (ED) with vaginal bleeding...
July 1, 2018: Curēus
https://www.readbyqxmd.com/read/30186417/association-of-mir-182-expression-in-amniotic-fluid-with-intrauterine-infection-and-brain-injury-in-premature-infants
#13
Fengchun Gao, Xiaojuan Jiang, Qirong Li, Kefeng Fan
Changes of micro-ribonucleic acid-182 (miR-182) level in cases of intrauterine infection were investigated to explore the association between miR-182 level change and brain injury in premature infants. A total of 257 preterm infants born in obstetrics department of Jinan Maternity and Child Care Hospital from February 2015 to February 2017 were enrolled in this study. These preterm infants were divided into infected group (n=113) and uninfected group (n=144) based on pathological diagnosis results. Quantitative polymerase chain reaction (qPCR) was employed to detect miR-182 level in amniotic fluid...
September 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30185500/clinical-presentation-and-treatment-of-amniotic-fluid-embolism
#14
Anne-Marie McBride
Obstetric emergencies often require intensive care intervention. Amniotic fluid embolism is a rare, unpredictable, and often catastrophic complication of pregnancy that is suspected in a woman who experiences cardiac arrest after a cesarean section. The condition occurs in approximately 1 in 40 000 births and has an average case-fatality rate of 16%. This complication may result from activation of an inflammatory response to fetal tissue in the maternal circulation. Risk factors may include maternal age over 35 years and conditions in which fluid can exchange between the maternal and fetal circulations...
2018: AACN Advanced Critical Care
https://www.readbyqxmd.com/read/30185063/assessment-of-22-inorganic-elements-in-human-amniotic-fluid-a-cross-sectional-study-conducted-in-canary-islands-spain
#15
Luis Alberto Henríquez-Hernández, Octavio P Luzardo, Luis D Boada, Ana González-Antuña, Ana Isabel Domínguez-Bencomo, Manuel Zumbado, Guillermo Burillo-Putze
We conducted a cross-sectional study in the Hospital Universitario de Canarias (Tenerife, Canary Islands, Spain) measuring 22 inorganic elements in amniotic fluid (AF) samples obtained from 65 pregnant women. ICP-MS was used for quantification of inorganic elements. Newborn parameters at delivery were all within the normal range. Concentrations of all elements were detected in measurable amounts in AF. The concentration of elements was similar to those reported in the literature. The concentrations of the most dangerous heavy metals - Cd, Cr, Ni, Hg and Pb - were lower than those reported by other authors...
September 6, 2018: International Journal of Environmental Health Research
https://www.readbyqxmd.com/read/30177949/prenatal-diagnosis-of-recurrent-distal-1q21-1-duplication-in-three-fetuses-with-ultrasound-anomalies
#16
Xiuqing Ji, Qiong Pan, Yan Wang, Yun Wu, Jing Zhou, An Liu, Fengchang Qiao, Dingyuan Ma, Ping Hu, Zhengfeng Xu
Background: The phenotype of duplication of 1q21.1 region is variable, ranging from macrocephaly, autism spectrum disorder, congenital anomalies, to a normal phenotype. Few cases have been reported in the literature regarding prenatal diagnosis of 1q21.1 duplication syndrome. The current study presents prenatal diagnosis of 1q21.1 duplication syndrome in three fetuses with ultrasound anomalies. Case presentation: Three fetuses from three unrelated families were included in the study. The prenatal routine ultrasound examination showed nasal bone loss in Fetus 1 and Fetus 3, as well as duodenal atresia in Fetus 2...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/30174955/-trichomonas-vaginalis-transports-virulent-mycoplasma-hominis-and-transmits-the-infection-to-human-cells-after-metronidazole-treatment-a-potential-role-in-bacterial-invasion-of-fetal-membranes-and-amniotic-fluid
#17
Tran Thi Trung Thu, Valentina Margarita, Anna Rita Cocco, Alessandra Marongiu, Daniele Dessì, Paola Rappelli, Pier Luigi Fiori
Mycoplasma hominis is considered an opportunistic pathogen able to colonize the lower urogenital tract; in females the infection is associated with severe pregnancy and postpartum complications, including abortion, endometritis, preterm delivery, and low birth weight. Molecular mechanisms of pathogenicity and virulence effectors remain poorly characterized. A number of studies in the last decade have demonstrated that M. hominis can establish an endosymbiotic relationship with Trichomonas vaginalis , a urogenital parasitic protozoon, also associated with adverse pregnancy outcomes...
2018: Journal of Pregnancy
https://www.readbyqxmd.com/read/30173596/description-of-a-rare-%C3%AE-globin-gene-mutation-86-c-g-hbb-c-136c-g-observed-in-a-syrian-family
#18
Faten Moassas, Ayman Alabloog, Hossam Murad
We present the description of a β-thalassemia (β-thal) -86 (C>G) (HBB: c.-136C>G) mutation in a Syrian family from Damascus, As-Suwayda Province, Syria, who was referred to the laboratory for prenatal diagnosis (PND). The mutation was found in the mother in a homozygous state, while it was in the father and in the amniotic fluid sample in a heterozygous state. This mutation is located at -86 within the proximal CACCC box in the promoter of the β-globin gene and is possibly linked with a phenotype of β+ -thal...
September 3, 2018: Hemoglobin
https://www.readbyqxmd.com/read/30160974/intestinal-imino-transporter-sit1-is-not-expressed-in-human-newborns
#19
Chantal Florence Meier, Simone M R Camargo, Schirin Hunziker, Ueli Moehrlen, Stephanie J Gros, Peter Karl Bode, Svenja Leu, Martin Meuli, Stefan Holland-Cunz, François Verrey, Raphael Nicolas Vuille-Dit-Bille
The expression of amino acid transporters in small intestine epithelium of human newborns has not been studied yet. It is further not known whether the maturation of imino acid (proline) transport is delayed as in kidney proximal tubule. The possibility to obtain small intestinal tissue from patients undergoing surgery for jejunal or ileal atresia during their first days after birth was used to address these questions. As control, adult terminal ileum tissue was sampled during routine endoscopies. Gene expression of luminal imino- and amino acid transporter SIT1 (SLC6A20) was approximately 3-fold lower in newborns versus adults...
August 30, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/30160618/yield-of-meconium-in-non-vigorous-neonates-undergoing-endotracheal-suctioning-and-profile-of-all-neonates-born-through-meconium-stained-amniotic-fluid-a-prospective-observational-study
#20
V R Viraraghavan, Sushma Nangia, B H Prathik, Babu S Madarkar, Deepshika Rani, Arvind Saili
BACKGROUND: Delivery room management of infants born via meconium-stained amniotic fluid (MSAF) is quite controversial. No study has tried to quantify the amount of meconium that can be aspirated from the trachea of a non-vigorous neonate born through MSAF. AIMS: To study the yield of meconium in non-vigorous neonates born through MSAF undergoing endotracheal (ET) suctioning. METHODS: This was a prospective observational study conducted from 1 March 2015 to 31 October 2015...
August 30, 2018: Paediatrics and International Child Health
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