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https://www.readbyqxmd.com/read/29734759/trends-in-the-prevalences-of-selected-birth-defects-in-korea-2008%C3%A2-2014
#1
Jung-Keun Ko, Dirga Kumar Lamichhane, Hwan-Cheol Kim, Jong-Han Leem
Little information is available on the prevalences of birth defects in Korea. The aims of this study were to estimate recent prevalences of selected birth defects and to analyze the prevalence trends of these defects during the period from 2008 to 2014. Prevalences were calculated for 69 major birth defects using health insurance claim data obtained from the Korea National Health Insurance Service (NHIS). Prevalence rate ratios were calculated using Poisson regression to analyze trends over the 7-year study period...
May 5, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29726646/-orchidopexy-increases-the-levels-of-serum-anti-m%C3%A3-llerian-hormone-and-inhibin-b-in-cryptorchidism-patients
#2
Shun-Shun Cao, Yang-Yang Hu, Cun-Jin Nan
Objective: To investigate the levels of serum anti-Müllerian hormone (AMH) and inhibin B (INHB) in patients with unilateral cryptorchidism before and after orchidopexy. METHODS: This study included 58 cases of unilateral cryptorchidism treated by orchidopexy and 32 healthy controls. Before and at 6 months after surgery, we measured the length and circumference of the penis, the volume of the undescended testis, and levels of serum AMH and INHB. RESULTS: There were statistically significant differences between the unilateral cryptorchidism and healthy control groups in the levels of serum AMH ([102...
August 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29726645/-single-scrotal-incision-orchidopexy-without-ligation-of-processus-vaginalis-for-palpable-undescended-testis
#3
Yi Chen, Jun-Feng Zhao, Fu-Ran Wang, Yan Li, Zhan Shi, Hong-Ji Zhong, Jian-Ming Zhu
Objective: To determine the feasibility and short-term effect of single scrotal-incision orchidopexy (SSIO) without ligation of the processus vaginalis (PV) in the treatment of palpable undescended testis (PUDT). METHODS: This retrospective study included 109 cases of PUDT (125 sides) and 15 cases of impalpable undescended testis (IUDT). The former underwent SSIO without PV ligation (group A, n = 53) or standard inguinal orchidopexy with PV ligation (group B, n = 56) while the latter received laparoscopic exploration (group C)...
August 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29713311/cryptorchidism-in-boys-with-cerebral-palsy-is-associated-with-the-severity-of-disease-and-with-co-occurrence-of-other-congenital-anomalies
#4
Julia Spencer Barthold, Anton Wintner, Jennifer A Hagerty, Kenneth J Rogers, Md Jobayer Hossain
Background: Cryptorchidism is reported in 40-50% of small case series of cerebral palsy (CP) and attributed to hypothalamic-pituitary-gonadal axis abnormalities, intellectual disability (ID), or cremaster spasticity. We collected demographic and clinical data to define the frequency of cryptorchidism and clinical comorbidities in a large CP population. Methods: Electronic health record data were collected for all male patients ≥7 years of age seen in a large, multidisciplinary CP clinic between 2000 and 2016...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29687786/a-novel-mutation-of-amhr2-in-two-siblings-with-persistent-m%C3%A3-llerian-duct-syndrome
#5
Edip Unal, Ruken Yıldırım, Suat Tekin, Vasfiye Demir, Hüseyin Onay, Yusuf Kenan Haspolat
Persistent Müllerian Duct syndrome (PMDS) develops due to deficiency of anti-Müllerian hormone (AMH) or insensitivity of target organs to AMH in people with 46, XY karyotype. PMDS is characterized with normal male phenotype of external genital associated with persistence of Müllerian structures. The 2.5 years old male patient presented due to bilateral undescended testis. Karyotype was 46, XY. The amount of increase in testosterone following human chorionic gonadotropin (hCG) stimulation test was normal...
April 24, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29674406/spontaneous-rupture-of-seminoma-in-undescended-testis-with-hemoperitoneum-a-rare-presentation
#6
Deepak Kumar Diwakar, Nikita Wadhwani, Ravi Shekhar Pradhan, Ravi Prakash Verma
Cryptorchidism is associated with increased risk of malignancy and infertility. We present a case of a 30-year-old man who presented to the Emergency Department of our tertiary care hospital with spontaneous intra-abdominal rupture of the seminoma in undescended testis with hemoperitoneum. This is a rare presentation of seminoma and emphasises the importance of scrotal examination in young men presenting with acute abdomen. Surgical management is the definitive treatment and should be instituted as soon as possible, after appropriate resuscitation...
April 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29671528/testicular-cancer-diagnosis-and-treatment
#7
Drew C Baird, Garrett J Meyers, Jocelyn S Hu
Testicular cancer is the most common solid tumor among males 15 to 34 years of age, with an estimated 8,850 new cases and 410 deaths during 2017 in the United States. With effective treatment, the overall five-year survival rate is 97%. Risk factors for testicular cancer include undescended testis (cryptorchidism), personal or family history of testicular cancer, age, ethnicity, and infertility. The U.S. Preventive Services Task Force recommends against routine screening in asymptomatic men. Men with symptoms should receive a complete history and physical examination...
February 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29620548/age-at-presentation-of-undescended-testicles-a-single-center-study-in-saudi-arabia
#8
Jumanah H Basalelah, Abdullah M Alzahrani, Abdulaziz M Alshaibani, Nasser S Alalyani, Turki A Alsubiani, Maha Khalid AlMadi, Ossamah S Allsowayan
BACKGROUND: The undescended testis (UDT) is the most common genital anomaly encountered in pediatrics with an estimated incidence of 1% to 4% in full-term and 1% to 45% in preterm newborn boys. Over the years, studies on progressive histological deterioration and cancer risk has led to a change in recommendations for when orchidopexy should be done. OBJECTIVES: Determine age at presentation of patients for UDT to a specialist in Saudi Arabia, age of operation and whether the recommended targeted time frame has been met...
March 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29618007/subphenotype-meta-analysis-of-testicular-cancer-genome-wide-association-study-data-suggests-a-role-for-rbfox-family-genes-in-cryptorchidism-susceptibility
#9
Yanping Wang, Dione R Gray, Alan K Robbins, Erin L Crowgey, Stephen J Chanock, Mark H Greene, Katherine A McGlynn, Katherine Nathanson, Clare Turnbull, Zhaoming Wang, Marcella Devoto, Julia Spencer Barthold
STUDY QUESTION: Can subphenotype analysis of genome-wide association study (GWAS) data from subjects with testicular germ cell tumor (TGCT) provide insight into cryptorchidism (undescended testis, UDT) susceptibility? SUMMARY ANSWER: Suggestive intragenic GWAS signals common to UDT, TGCT case-case and TGCT case-control analyses occur in genes encoding RBFOX RNA-binding proteins (RBPs) and their neurodevelopmental targets. WHAT IS KNOWN ALREADY: UDT is a strong risk factor for TGCT, but while genetic risk factors for TGCT are well-known, genetic susceptibility to UDT is poorly understood and appears to be more complex...
March 29, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29615365/detection-of-insulin-like-growth-factor-receptor-1-in-the-human-cremaster-muscle-and-its-role-in-the-etiology-of-the-undescended-testis
#10
Mustafa Yaşar Özdamar, Sevinç Şahin, Kürşad Zengin, Selda Seçkin, Mesut Gürdal
PURPOSE: Previous studies of undescended testis (UT) has focused on insulin-like hormone 3 (INSL3), the genitofemoral nerve, and androgens in the testicular descent. Leydig cells, which are under the control of insulin-like growth factor-1 (IGF1), produce both androgens and INSL3. We aimed to investigate whether insulin-like growth factor receptor-1(IGFR1) exists in the cremaster muscle (CM) complex and is associated with normally descended testis as well as UT cases in humans. METHODS: We studied 30 CM from 15 patients who comprised the UT group (UTG), and 15 patients with unilateral testicular torsion (Control group; CG)...
March 31, 2018: Asian Journal of Surgery
https://www.readbyqxmd.com/read/29594470/testicular-atrophy-following-inguinal-hernia-repair-in-children
#11
Kristin A Sonderman, Lindsey L Wolf, Lindsey B Armstrong, Kathryn Taylor, Wei Jiang, Brent R Weil, Tracey P Koehlmoos, Robert L Ricca, Christopher B Weldon, Adil H Haider, Samuel E Rice-Townsend
PURPOSE: We sought to determine the incidence and timing of testicular atrophy following inguinal hernia repair in children. METHODS: We used the TRICARE database, which tracks care delivered to active and retired members of the US Armed Forces and their dependents, including > 3 million children. We abstracted data on male children < 12 years who underwent inguinal hernia repair (2005-2014). We excluded patients with history of testicular atrophy, malignancy or prior related operation...
March 28, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29572364/testicular-torsion-in-a-patient-with-ehlers-danlos-syndrome
#12
Amy Lee Fowler, David Bouchier Hayes, Eszter Feher
We present a 19-year-old man with a diagnosis of Ehlers-Danlos syndrome (EDS) and a delayed presentation of testicular torsion. EDS is a rare and heterogeneous condition affecting collagen synthesis and presents multiple difficulties in a surgical setting. Management of this case of testicular torsion was complicated by impaired cognition of the patient, difficulty with intubation, a contralateral undescended testis and postoperative bleeding. We discuss the specific challenges faced in this case of testicular torsion with longstanding ischaemia and perioperative considerations of EDS...
March 22, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29572060/a-survey-of-the-current-practice-patterns-of-contralateral-testis-fixation-in-unilateral-testicular-conditions
#13
Ahmed Abdelhalim, Joshua D Chamberlin, Irene M McAleer
OBJECTIVE: To query the current contralateral testis fixation (CTF) practice patterns among pediatric urologists in different clinical situations that could result in monorchism. MATERIALS AND METHODS: An online survey was sent to members of the Urology Section of the American Academy of Pediatrics. The survey included questions addressing CTF practice patterns in 14 clinical scenarios. Responses were anonymously submitted, blindly reviewed and analyzed. RESULTS: Among 53 respondents, 62...
March 20, 2018: Urology
https://www.readbyqxmd.com/read/29549377/a-case-of-a-child-with-undescended-left-testis-presenting-with-acute-right-scrotal-swelling
#14
Shi Yuan Wang, Ehab Shaban Mahmoud Hamouda
No abstract text is available yet for this article.
February 2018: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29511588/management-of-the-patients-with-persistent-m%C3%A3-llerian-duct-syndrome-is-the-ultimate-goal-testicular-descent
#15
Serpil Sancar, Esra Özçakır, Mete Kaya
Objective: Persistent Müllerian duct syndrome (PMDS) is a rare congenital disease characterized by the presence of rudimentary Müllerian structures within an intra-abdominal or hernial sac in a virilized male, often presenting as undescended testes. In this study, we aim to present a series of the PMDS patients who were managed by orchiopexy without removal of Müllerian remnants (MR). Material and methods: Between May 2010 and June 2017, we treated six cases diagnosed as PMDS in our department...
March 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29451709/shortcomings-in-the-management-of-undescended-testis-guideline-intention-vs-reality-and-the-underlying-causes-insights-from-the-biggest-german-cohort
#16
Philip Boehme, Berit Geis, Johannes Doerner, Stefan Wirth, Kai O Hensel
OBJECTIVES: To assess the implementation of the current guideline and identify potential underlying causes for late surgery in children with undescended testis (UDT) in Germany. UDT is the most common surgical issue in paediatric urology and to avoid malignant degeneration and subfertility current guidelines recommend orchidopexy during the first year of life; however, this seems not to be implemented in practice. PATIENTS AND METHODS: In all, 5 547 patients with cryptorchidism at 16 hospitals nationwide were studied regarding age at orchidopexy between 2003 and 2016...
February 16, 2018: BJU International
https://www.readbyqxmd.com/read/29429771/gonocyte-transformation-in-a-congenitally-cryptorchid-rat-is-normal-and-may-be-similar-to-the-situation-reported-in-human-acquired-cryptorchidism
#17
Moshe Loebenstein, John Hutson, Ruili Li
BACKGROUND: In congenital undescended testis (UDT) in humans, thermal insult damages early germ cell development during mini-puberty (3-6months) causing increased risk of both cancer and infertility. In rodents however, UDT causes infertility but not cancer. In the TS rat with congenital UDT we hypothesized that early germ cell development would be normal as UDT only becomes manifest at 3-4weeks (and the germ cells only become sensitive to thermal injury) after minipuberty is complete at 1week...
January 31, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29429568/testicular-torsion-in-an-infant-with-undescended-testis
#18
Kazuki Iio, Osamu Nomura, Akiko Kinumaki, Yujiro Aoki, Hiroyuki Satoh, Hiroshi Sakakibara, Hiroshi Hataya
No abstract text is available yet for this article.
February 8, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29384904/ectopic-immature-renal-tissue-in-gubernaculum-associated-with-undescended-testis-of-a-1-year-old-child-a-case-report
#19
Tingting Bian, Jianguo Zhang, Wenliang Ge, Jia Feng, Yifei Liu
RATIONALE: Ectopic immature renal tissue (EIRT) is extremely rare in congenital malformations. Moreover, the fundamental pathogenesis of EIRT is still unclear and controversial. PATIENT CONCERNS: The right scrotum of a 1-year-old man was found empty for a period of 1 month. B-ultrasonography revealed normal bilateral kidneys and a hypoechoic nodule in the right groin. DIAGNOSES: Based on B-ultrasonography, surgery and pathological examination, we concluded a case of abnormally located and EIRT in the inguinal canal...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29369248/experience-of-using-shear-wave-elastography-imaging-in-evaluation-of-undescended-testes-in-children-feasibility-reproducibility-and-clinical-potential
#20
Mehmet Sedat Durmaz, Mesut Sivri, Tamer Sekmenli, Canan Kocaoğlu, İlhan Çiftçi
We aimed to determine the difference in tissue stiffness, which might reflect histologic damage, by comparing the potential of the shear wave elastography (SWE) values of operated undescended testes (OUT) with those of undescended testes (UT) and normal testes. A total of 120 patients (235 testes) were enrolled in the current study. Quantitative SWE values were measured by manually drawing contours of the entire testis structure with a free region of interest. A group of 66 OUT were classified as group A. Operation age and the period passed over the operation time and SWE values were compared among the testes assigned to group A...
January 23, 2018: Ultrasound Quarterly
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