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Raynaud phenomenon

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https://www.readbyqxmd.com/read/27899893/raynaud-s-phenomenon-a-brief-review-of-the-underlying-mechanisms
#1
REVIEW
Manal M Fardoun, Joseph Nassif, Khodr Issa, Elias Baydoun, Ali H Eid
Raynaud's phenomenon (RP) is characterized by exaggerated cold-induced vasoconstriction. This augmented vasoconstriction occurs by virtue of a reflex response to cooling via the sympathetic nervous system as well as by local activation of α2C adrenoceptors (α2C-AR). In a cold-initiated, mitochondrion-mediated mechanism involving reactive oxygen species and the Rho/ROCK pathway, cytoskeletal rearrangement in vascular smooth muscle cells orchestrates the translocation of α2C-AR to the cell membrane, where this receptor readily interacts with its ligand...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27895669/myeloproliferative-disease-an-unusual-cause-of-raynaud-s-phenomenon-and-digital-ischaemia
#2
Celia Beynon, Gwenan Huws, Tom Lawson
We describe a 59-year-old female who presented with ischaemic digits, preceded by a 6-month history of Raynaud's phenomenon affecting her fingers and toes. There were no clinical or laboratory features of primary vasculitis or connective tissue disease, Doppler imaging was normal, and bloods were unremarkable aside from a platelet count of 786 × 109/L (150-400) and white cells of 16 × 109/L (4-11). In view of the thrombocytosis a JAK2 mutation assay was requested which confirmed a JAK2 V617F mutation, suggesting essential thrombocytosis (ET) as the cause...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27885347/fludarabine-treatment-of-patient-with-chronic-lymphocytic-leukemia-induces-a-digital-ischemia
#3
Utku Erdem Soyaltin, Deniz Yuce Yildirim, Mustafa Yildirim, Mehmet Can Ugur, Ferhat Ekinci, Cengiz Ceylan, Harun Akar
We report a 63-year-old man with a history of chronic lymphocytic leukemia (CLL) who presented with asymmetrical Raynaud's phenomenon of sudden onset which progressed to acral gangrene rapidly in a week. These symptoms began approximately one week after the fourth cycle of fludarabine and cyclophosphamide chemotherapy and were accompanied by pain, numbness, and cyanosis in the fingers of his right hand except the first finger. Fludarabine may play a role in acral vascular syndrome. The treatment with fludarabine in patients with evolving digital ischemia should be carried out with caution...
2016: Case Reports in Hematology
https://www.readbyqxmd.com/read/27870974/myocardial-perfusion-in-peripheral-raynaud-s-phenomenon-evaluation-using-stress-cardiovascular-magnetic-resonance
#4
Sophie Mavrogeni, Konstantinos Bratis, Loukia Koutsogeorgopoulou, Georgia Karabela, Efthymios Savropoulos, Gikas Katsifis, John Raftakis, George Markousis-Mavrogenis, Genovefa Kolovou
BACKGROUND: Peripheral Raynaud's phenomenon (RP) is either primary (PRP), without any coexisting disease or secondary (SRP), due to connective tissue diseases (CTD). We hypothesized that adenosine stress cardiovascular magnetic resonance (CMR) can assess myocardial perfusion in a population of PRP and SRP. PATIENTS-METHODS: Twenty CTDs, aged 30.6±7.5yrs., 16F/4M, including 9 systemic sclerosis (SSc), 4 systemic lupus erythematosus (SLE), 3 mixed connective tissue disease (MCTD), 2 polymyositis (PM) and 2 rheumatoid arthritis (RA), with SRP, under treatment with calcium blockers, were evaluated by stress CMR and compared with age-sex matched PRP and controls...
November 12, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27851803/the-2013-american-college-of-rheumatology-european-league-against-rheumatism-classification-criteria-for-systemic-sclerosis-could-classify-systemic-sclerosis-patients-at-earlier-stage-data-from-a-chinese-eustar-center
#5
Dong Xu, Yong Hou, Yuanfang Zheng, Yue Zheng, Mengtao Li, Xiaofeng Zeng
OBJECTIVES: To evaluate the performance of the 2013 ACR/EULAR classification criteria for systemic sclerosis (SSc) in clinical practice in a Chinese patient cohort, and to compare outcomes with the 1980 ACR criteria. METHODS: Patients clinically diagnosed with SSc between September 2013 and May 2015 were prospectively recruited from the EUSTAR database of the Peking Union Medical College Hospital. Diagnosis of SSc was based on the evaluation of three experienced rheumatologists...
2016: PloS One
https://www.readbyqxmd.com/read/27837194/lenalidomide-for-refractory-cutaneous-manifestations-of-pediatric-systemic-lupus-erythematosus
#6
E Y Wu, L E Schanberg, E C Wershba, C E Rabinovich
OBJECTIVE: Cutaneous manifestations of pediatric systemic lupus erythematosus cause significant morbidity. Lenalidomide, a thalidomide analogue, has shown promise treating cutaneous lupus erythematosus in adults. Our objective was to evaluate lenalidomide's efficacy and safety in treating refractory cutaneous manifestations of pediatric systemic lupus erythematosus. METHODS: We performed a retrospective chart review of 10 adolescents who received lenalidomide for recalcitrant cutaneous lupus erythematosus...
November 10, 2016: Lupus
https://www.readbyqxmd.com/read/27834783/neonatal-beh%C3%A3-et-s-disease-with-raynaud-phenomenon
#7
J R Fernández-Fructuoso, S Gil-Sánchez, E Gómez-Santos, J M Lloreda-García, S Sevilla-Denia, J L Leante-Castellanos
We report a new clinical manifestation of neonatal Behcet's disease. A newborn from a mother with active Behcet's disease during pregnancy, who develops vasomotor phenomena (Raynaud) with oral ulcerations in the second day of life. Neonatal mucocutaneous lesions have been reported previously in few newborns of pregnant women with active Behçet disease. Although neonatal disease is a very infrequent situation, with a mostly transient and favorable course, clinicians should be aware of serious potential complications associated with this entity...
November 9, 2016: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/27833984/a-case-of-a-generalized-symptomatic-calcinosis-in-systemic-sclerosis
#8
Cristian Radu Jecan, Ştefan Iulian Bedereag, Ruxandra Diana Sinescu, Valentin Titus Grigorean, Cristina Nicoleta Cozma, Anca Bordianu, Ioan Petre Florescu
Calcinosis consists of abnormal calcium deposition in soft tissues, which appears often in patients with limited systemic sclerosis, being one of the criteria of CREST (calcinosis cutis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia) syndrome. With a long evolution, the aim of the treatment is to control the symptoms and prevent complications. In this article, we present the challenging management of a profuse lesion of calcinosis in a patient with systemic sclerosis. We describe the case of a 52-year-old woman with systemic sclerosis and CREST syndrome who was admitted in our Department with multiple painful and disabling tumoral masses, situated in nearly all joints...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27830961/classification-of-japanese-patients-with-mild-early-systemic-sclerosis-ssc-by-the-2013-acr-eular-classification-criteria-for-ssc
#9
Yuka Ikawa, Yasuhito Hamaguchi, Naoki Mugii, Takashi Matsushita, Kazuhiko Takehara
OBJECTIVE: To classify Japanese patients with mild/early systemic sclerosis (SSc) by the 2013 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) Classification Criteria (new 2013 criteria). METHODS: We assessed 120 patients who visited Kanazawa University Hospital suspected of SSc and who did not meet the 1980 ACR preliminary classification criteria for SSc. We clinically diagnosed 16 patients with primary Raynaud's disease and 104 with mild/early SSc prior to being assessed by the new 2013 criteria...
November 10, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27828653/syndrome-in-question-antisynthetase-syndrome-anti-pl-7
#10
Ana Cláudia Cavalcante Esposito, Tatiana Cristina Gige, Hélio Amante Miot
Antisynthetase syndrome is a rare autoimmune disease characterized by interstitial lung disease and/or inflammatory myositis, with positive antisynthetase antibodies (anti-Jo-1, anti-PL-7, anti-PL-12, ZO, OJ, anti-KE or KS). Other symptoms described include: non-erosive arthritis, fever, Raynaud's phenomenon, and "mechanic's hands." The first therapeutic option is corticotherapy, followed by other immunosuppressants. The prognosis of the disease is quite limited when compared to other inflammatory myopathies with negative antisynthetase antibodies...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27799439/systemic-lupus-erythematosus-in-spanish-males-a-study-of-the-spanish-rheumatology-society-lupus-registry-relesser-cohort
#11
A Riveros Frutos, I Casas, I Rúa-Figueroa, F J López-Longo, J Calvo-Alén, M Galindo, A Fernández-Nebro, J M Pego-Reigosa, A Olivé Marqués
OBJECTIVE: The objective of this study was to describe the demographic, clinical, and immunological manifestations of systemic lupus erythematosus (SLE) in male patients. METHODS: A cross-sectional, multicenter study was carried out of 3651 patients (353 men, 9.7%, and 3298 women, 90.2%) diagnosed with SLE, included in the Spanish Rheumatology Society SLE Registry (RELESSER). RESULTS: Mean ages (18-92 years) of symptom onset were 37 (SD 17) years (men) and 32 (SD 14) years (women)...
October 31, 2016: Lupus
https://www.readbyqxmd.com/read/27783160/diagnosis-of-raynaud-s-phenomenon-by-99m-tc-pertechnetate-hand-perfusion-scintigraphy-a-pilot-study
#12
Slavica Pavlov-Dolijanovic, Nebojsa Petrovic, Nada Vujasinovic Stupar, Nemanja Damjanov, Goran Radunovic, Dragan Babic, Dragana Sobic-Saranovic, Vera Artiko
We assess the usefulness of (99m)Tc-pertechnetate hand perfusion scintigraphy in patients with Raynaud's phenomenon (RP). The study population consisted of 18 patients with primary RP, 25 patients with secondary RP within systemic sclerosis (SSc), and ten healthy individuals. Gamma camera dynamic first-pass study during the first 60 s and a static scintigraphy after 5 min were recorded following a bolus injection of (99m)Tc-pertechnetate via a cubital vein. Regions of interest were drawn on the summed images around the fingers and the palmar region...
October 25, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27751625/paraneoplastic-systemic-sclerosis-about-3-cases-and-review-of-literature
#13
J-B Monfort, I Lazareth, P Priollet
OBJECTIVE: Association between cancer and systemic sclerosis (SSc) has been described. However, paraneoplastic SSc is not well known. The aim of this article is to describe cases of paraneoplastic systemic sclerosis and to compare them to other cases of the literature, to find characteristics that can make suspect a paraneoplastic mechanism when SSc is diagnosed. METHODS: We retrospectively analyzed patients, in our department who, over the last 15 years, presented with Raynaud's phenomenon with a diagnosis of SSc (including cancer during the period of SSc)...
October 14, 2016: Journal des Maladies Vasculaires
https://www.readbyqxmd.com/read/27749585/a-case-report-of-the-beneficial-effects-of-botulinum-toxin-type-a-on-raynaud-phenomenon-in-a-patient-with-lung-cancer
#14
Lu Wang, Qi-Song Lei, Yu-Ying Liu, Guan-Jie Song, Chun-Ling Song
OBJECTIVE: Raynaud phenomenon is a vasospastic disorder affecting the hands and feet, and the efficacies of traditional treatments, such as pharmacological therapies and sympathectomy, are not uniform. Patients with paraneoplastic Raynaud phenomenon do not benefit from the traditional treatments. The use of botulinum toxin type A (BTX-A) for Raynaud phenomenon has been reported for several years; however, there are few reports regarding botulinum toxin type A in the treatment of paraneoplastic Raynaud phenomenon...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27748811/danggui%C3%A2-sayuk%C3%A2-ga%C3%A2-osuyu%C3%A2-senggang%C3%A2-tang-ameliorates-cold%C3%A2-induced-vasoconstriction-in%C3%A2-vitro-and-in%C3%A2-vivo
#15
Kangwook Lee, Sung-Gook Cho, Sang-Mi Woo, Ah Jeong Kim, Kang Min Lee, Ho Yeon Go, Seung-Ho Sun, Tae-Hun Kim, Ki-Yong Jung, You-Kyung Choi, Eun Mee Lim, Yun-Kyung Song, Jong-Hyeong Park, Chan-Yong Jun, Seong-Gyu Ko
Danggui-Sayuk-Ga-Osuyu-Senggang-Tang (DSGOST), one of the traditional Chinese medicines, has long been prescribed for patients suffering from Raynaud phenomenon (RP) in Northeast Asian countries, including China, Japan and Korea. Although a previous in vitro study from our laboratory revealed that DSGOST prevents cold (25˚C)‑induced RhoA activation and endothelin‑1 (ET‑1) production in endothelial cells (ECs), the mechanisms by which DSGOST is able to alleviate the symptoms of RP have yet to be fully elucidated...
October 5, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27747826/seasonal-and-geographic-variation-in-adverse-event-reporting
#16
Osvaldo Marrero, Eric Y Hung, Manfred Hauben
BACKGROUND: Many illnesses demonstrate seasonal and geographic variations. Pharmacovigilance is unique among public health surveillance systems in terms of the clinical diversity of the events under surveillance. Since many pharmacovigilance signal detection methodologies are geared towards looking for increased frequency of spontaneous adverse drug event (ADE) reporting over variable time frames, seasonality of ADEs may have implications for signal detection. OBJECTIVE: The aim of this study was to investigate whether a set of illnesses that might be expected to display seasonality in general, did so when spontaneously reported as ADEs...
September 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27744398/prevalence-of-systemic-sclerosis-in-primary-biliary-cholangitis-using-the-new-acr-eular-classification-criteria
#17
Boyang Zheng, Catherine Vincent, Marvin J Fritzler, Jean-Luc Senécal, Martial Koenig, France Joyal
OBJECTIVE: Systemic sclerosis (SSc) is a well-established disease associated with primary biliary cholangitis (PBC). However, the original 1980 American College of Rheumatology (ACR) criteria have poor sensitivity, especially for the detection of earlier SSc in previous studies. The objective was to evaluate the prevalence of SSc in patients with PBC using more sensitive 2001 LeRoy and Medsger criteria and the 2013 ACR/European League Against Rheumatism (EULAR) classification criteria...
October 15, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27731900/relationships-between-transepidermal-water-loss-cutaneous-microcirculatory-function-and-autonomic-nervous-activity
#18
Tomoko Nomura, Yasuko Yoshida-Amano, Kenichiro Yoshida, Akihiko Fujii, Masanori Tanahashi, Yoshinori Sugiyama, Kayoko Iwata, Takatoshi Murase
OBJECTIVE: Several studies have shown that a deterioration of skin properties, an impaired cutaneous microcirculation function and an imbalance of autonomic nervous activity are observed in smokers and in patients with diabetes mellitus or Raynaud's phenomenon. These observations suggest that skin properties are associated with cutaneous microcirculatory function and autonomic nervous activity in pathological conditions. However, there is no published evidence to support the concept that these two functions have any relationship with skin properties even in healthy subjects...
October 12, 2016: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/27727416/hammarsjuka-%C3%A3-r-ovanligt-%C3%A2-eller-bara-ett-ovanligt-f%C3%A3-rbisett-tillst%C3%A3-nd-effektiv-behandling-finns-%C3%A2-sk%C3%A3-rpt-differentialdiagnostik-%C3%A3-r-motiverad
#19
Anders Seldén, Fatin Hermiz, Bengt Östlund
Hypothenar hammer syndrome is a possibly underdiagnosed but treatable cause of Raynaud's phenomenon and hand ischemia elicited by thombosis or aneurysm secondary to acute or chronic blunt trauma to the ulnar artery at the level of Guyon's canal. This paper provides a summary of the condition with some emphasis on prophylactic and therapeutic aspects.
October 7, 2016: Läkartidningen
https://www.readbyqxmd.com/read/27722973/primary-raynaud-s-phenomenon-and-nailfold-videocapillaroscopy-age-related-changes-in-capillary-morphology
#20
Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Barbara Ruaro, Amelia Chiara Trombetta, Maurizio Cutolo, Sabrina Paolino
This study aimed to detect by nailfold videocapillaroscopy (NVC) the presence of age-related capillary morphological patterns in a large cohort of subjects affected by primary Raynaud's phenomenon (PRP). NVC was performed in 877 patients affected by PRP, divided into three age groups: <35, 35-55 and >55 years. The following qualitative parameters were assessed and compared in the three groups of patients: apical dilations, irregular (non-homogeneous) dilations, venous branch dilations, microhaemorrhages, tortuosities and subpapillary venous plexus visibility...
October 8, 2016: Clinical Rheumatology
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