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https://www.readbyqxmd.com/read/27933586/preparation-and-optimization-of-meropenem-loaded-solid-lipid-nanoparticles-in-vitro-evaluation-and-molecular-modeling
#1
Ellen K G Mhango, Rahul S Kalhapure, Mahantesh Jadhav, Sandeep J Sonawane, Chunderika Mocktar, Suresh Vepuri, Mahmoud Soliman, Thirumala Govender
Encapsulation of antibiotics into nanocarriers has the potential to overcome resistance and disadvantages associated with conventional dosage forms as well as increase half-life of an antibiotic. Encapsulation of meropenem (MRPN) into solid lipid nanoparticles (SLNs) remains unexplored among the limited work reported on nanoformulation incorporating MRPN. The study aimed to use an experimental design, to optimize MRPN-loaded SLNs, and to undertake in vitro and in silico evaluations. A Box-Behnken design (BBD) was used to optimize manufacturing conditions of glycerol monostearate (GMS) SLNs loaded with MRPN...
December 8, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27933225/rational-design-of-dual-active-sites-in-a-single-protein-scaffold-a-case-study-of-heme-protein-in-myoglobin
#2
Xiao-Gang Shu, Ji-Hu Su, Ke-Jie Du, Yong You, Shu-Qin Gao, Ge-Bo Wen, Xiangshi Tan, Ying-Wu Lin
Rational protein design has been proven to be a powerful tool for creating functional artificial proteins. Although many artificial metalloproteins with a single active site have been successfully created, those with dual active sites in a single protein scaffold are still relatively rare. In this study, we rationally designed dual active sites in a single heme protein scaffold, myoglobin (Mb), by retaining the native heme site and creating a copper-binding site remotely through a single mutation of Arg118 to His or Met...
June 2016: ChemistryOpen
https://www.readbyqxmd.com/read/27932873/coherence-between-self-reported-and-objectively-measured-physical-activity-in-patients-with-chronic-obstructive-lung-disease-a-systematic-review
#3
REVIEW
Mimi Thyregod, Uffe Bodtger
The beneficial effects of physical activity (PA) in patients with COPD, as well as the methods of their assessment, are well known and described. As objective measures of PA, such as the use of motion sensors, video recordings, exercise capacity testing, and indirect calorimetry, are not easily obtained in the daily clinical life, the reliability of the more accessible self-reported measurements of PA is important. In this review, we systematically identified original studies involving COPD patients and at least one parameter of self-reported and objective exercise testing, and analyzed every article for coherence between the objectively and self-reported measured PA...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27931150/in-vitro-synergism-of-a-water-insoluble-fraction-of-uncaria-tomentosa-combined-with-fluconazole-and-terbinafine-against-resistant-non-candida-albicans-isolates
#4
Renata Cougo Moraes, Anderson Ramos Carvalho, Aline Jacobi Dalla Lana, Samuel Kaiser, Bruna Pippi, Alexandre Meneghello Fuentefria, George González Ortega
CONTEXT: Uncaria tomentosa D.C. (Rubiaceae) has several biological activities, including activity against resistant Candida strains. The synergistic interaction with terbinafine or fluconazole can be an important alternative to overcome this resistance. OBJECTIVES: The potential synergy between a water insoluble fraction (WIF) from Uncaria tomentosa bark and the antifungals terbinafine (TRB) and fluconazole (FLZ) against non-Candida albicans resistant strains was investigated...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27930841/self-healing-behavior-in-a-thermo-mechanically-responsive-cocrystal-during-a-reversible-phase-transition
#5
Guangfeng Liu, Jie Liu, Xin Ye, Lina Nie, Peiyang Gu, Xutang Tao, Qichun Zhang
The molecular-level motions of a coronene-based supramolecular rotator are amplified into macroscopic changes of crystals by co-assembly of coronene and TCNB (1,2,4,5-tetracyanobenzene) into a charge-transfer complex. The as-prepared cocrystals show remarkable self-healing behavior and thermo-mechanical responses during thermally-induced reversible single-crystal-to-single-crystal (SCSC) phase transitions. Comprehensive analysis of the microscopic observations as well as differential scanning calorimetry (DSC) measurements and crystal habits reveal that a thermally-reduced-rate-dependent dynamic character exists in the phase transition...
December 8, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27928643/effect-of-polymorphs-of-cellulose-nanocrystal-on-the-thermal-properties-of-poly-lactic-acid-cellulose-nanocrystal-composites
#6
Junchai Zhao, Yujing Zhao, Zhao Wang, Zheng Peng
Cellulose nanocrystals (CNCs) with different polymorphs CNC I and II were fabricated from native and mercerized microcrystalline cellulose (MCC) by sulfuric acid hydrolysis. CNC I and II were successfully acetylated by a "green" method, which was performed in an ionic liquid of 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM]BF4). X-ray diffraction (XRD) proved that the crystal structure of CNC I and II was maintained after acetylation. Transmission electron microscopy (TEM) showed the rod-like structure for acetylated CNC I and spherical crystal morphologies for acetylated CNC II...
December 2016: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/27927989/crystal-structures-and-thermodynamic-analysis-reveal-distinct-mechanisms-of-cd28-phosphopeptide-binding-to-the-sh2-domains-of-three-adaptor-proteins
#7
Satomi Inaba, Nobutaka Numoto, Shuhei Ogawa, Hisayuki Morii, Teikichi Ikura, Ryo Abe, Nobutoshi Ito, Masayuki Oda
Full activation of T cells and differentiation into effector T cells is essential for many immune responses and requires co-stimulatory signaling via the CD28 receptor. Extracellular ligand binding to CD28 recruits protein tyrosine kinases to its cytoplasmic tail, which contains a YMNM motif. Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2), Grb2-related adaptor downstream of Shc (Gads), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM via their SH2 domains, leading to downstream signaling to distinct immune pathways...
December 6, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27925048/resting-energy-expenditure-in-critically-ill-patients-evaluation-methods-and-clinical-applications
#8
Ana Cláudia Soncini Sanches, Cassiana Regina de Góes, Marina Nogueira Berbel Bufarah, André Luiz Balbi, Daniela Ponce
Patients on intensive care present systemic, metabolic, and hormonal alterations that may adversely affect their nutritional condition and lead to fast and important depletion of lean mass and malnutrition. Several factors and medical conditions can influence the energy expenditure (EE) of critically ill patients, such as age, gender, surgery, serious infections, medications, ventilation modality, and organ dysfunction. Clinical conditions that can present with EE change include acute kidney injury, a complex disorder commonly seen in critically ill patients with manifestations that can range from minimum elevations in serum creatinine to renal failure requiring dialysis...
October 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27924998/optimization-of-water-content-for-the-cryopreservation-of-allium-sativum-in-vitro-cultures-by-encapsulation-dehydration
#9
P T Lynch, G R Souch, J Zamecnik, K Harding
BACKGROUND: There is a general requirement to determine and correlate water content to viability for the standardization of conservation protocols to facilitate effective cryostorage of plant germplasm. OBJECTIVE: This study examined water content as a critical factor to optimize the cryostorage of Allium sativum. MATERIALS AND METHODS: Stem discs were excised from post-harvest, stored bulbs prior to cryopreservation by encapsulation-dehydration and water content was determined gravimetrically...
September 2016: Cryo Letters
https://www.readbyqxmd.com/read/27924278/domain-based-biophysical-characterization-of-the-structural-and-thermal-stability-of-flig-an-essential-rotor-component-of-the-na-driven-flagellar-motor
#10
Yasuhiro Onoue, Rei Abe-Yoshizumi, Mizuki Gohara, Yuuki Nishino, Shiori Kobayashi, Yasuo Asami, Michio Homma
Many bacteria move using their flagellar motor, which generates torque through the interaction between the stator and rotor. The most important component of the rotor for torque generation is FliG. FliG consists of three domains: FliGN, FliGM, and FliGC. FliGC contains a site(s) that interacts with the stator. In this study, we examined the physical properties of three FliG constructs, FliGFull, FliGMC, and FliGC, derived from sodium-driven polar flagella of marine Vibrio. Size exclusion chromatography revealed that FliG changes conformational states under two different pH conditions...
2016: Biophysics and Physicobiology
https://www.readbyqxmd.com/read/27923492/hydrogen-bonding-interactions-and-enthalpy-relaxation-in-sugar-protein-glasses
#11
Bulat Sydykov, Harriëtte Oldenhof, Harald Sieme, Willem F Wolkers
In this study, hydrogen bonding interactions and enthalpy relaxation phenomena of sugar and sugar/protein glasses have been studied using Fourier transform infrared spectroscopy and differential scanning calorimetry. The sugar OH band in Fourier transform infrared spectra was used to derive the glass transition temperature, Tg, and the wavenumber-temperature coefficient (WTC) of the OH band. A study on mixtures of sucrose and albumin revealed that the glass transition temperature and strength of hydrogen bonds increased with increasing percentages of albumin...
December 3, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27923279/does-exercise-training-affect-resting-metabolic-rate-in-adolescents-with-obesity
#12
Angela S Alberga, Denis Prud'homme, Ronald J Sigal, Gary S Goldfield, Stasia Hadjiyannakis, Réjeanne Gougeon, Penny Phillips, Janine Malcolm, George A Wells, Steve Doucette, Jinhui Ma, Glen P Kenny
We evaluated the hypothesis that resistance exercise training performed alone or in combination with aerobic exercise training would increase resting metabolic rate (RMR) relative to aerobic-only and nonexercising control groups. Postpubertal adolescents (N = 304) aged 14-18 years with obesity (body mass index (BMI) ≥ 95th percentile) or overweight (BMI ≥ 85th percentile + additional diabetes risk factor(s)) were randomized to 4 groups for 22 weeks: Aerobic exercise training, Resistance exercise training, Combined aerobic and resistance exercise training, or Control...
August 22, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27923210/study-on-the-interactional-behaviour-of-transition-metal-ions-with-myoglobin-a-detailed-calorimetric-spectroscopic-and-light-scattering-analysis
#13
Amandeep Kaur, Parampaul K Banipal, Tarlok S Banipal
The energetics and the impact on the conformation of heme containing protein myoglobin (Mb) due to the binding of three transition metal ions (Zn(2+), Ni(2+), and Mn(2+)) have been investigated using isothermal titration calorimetry (ITC), dynamic light scattering (DLS), UV-vis, and circular dichroism (CD) spectroscopy under physiological conditions. The binding affinity of the order of 10(4)M(-1) has been observed for all metal ions from calorimetry as well as from absorption spectroscopy. The binding of these metal ions with Mb is a spontaneous process that exposes the hydrophobic groups away from the protein core as exhibited by the negative Gibbs free energy change (ΔG) and positive heat capacity change (ΔCp) values...
November 27, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27923163/waste-conversion-into-high-value-ceramics-carbothermal-nitridation-synthesis-of-titanium-nitride-nanoparticles-using-automotive-shredder-waste
#14
Mohannad Mayyas, Farshid Pahlevani, Samane Maroufi, Zhao Liu, Veena Sahajwalla
Environmental concern about automotive shredder residue (ASR) has increased in recent years due to its harmful content of heavy metals. Although several approaches of ASR management have been suggested, these approaches remain commercially unproven. This study presents an alternative approach for ASR management where advanced materials can be generated as a by-product. In this approach, titanium nitride (TiN) has been thermally synthesized by nitriding pressed mixture of automotive shredder residue (ASR) and titanium oxide (TiO2)...
December 3, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27923141/development-and-characterization-of-electrosprayed-alyssum-homolocarpum-seed-gum-nanoparticles-for-encapsulation-of-d-limonene
#15
Khadije Khoshakhlagh, Arash Koocheki, Mohebbat Mohebbi, Alireza Allafchian
In this study, the feasibility of developing Alyssum homolocarpum seed gum (AHSG) nanocapsules containing d-limonene by electrospraying has been investigated. d-limonene emulsions with constant AHSG (0.5% w/w) and various flavor concentrations (10-30% based on gum weight) with 0.1% Tween 20 were electrosprayed at 20kV and 0.1ml/h of flow rate. The effects of key parameters of emulsions (rheological properties, droplet size, surface tension and electrical conductivity) on the morphology of structures have been studied...
November 21, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27922938/skeletal-muscle-mass-is-associated-with-higher-dietary-protein-intake-and-lower-body-fat-in-postmenopausal-women-a-cross-sectional-study
#16
Thaís R Silva, Poli M Spritzer
OBJECTIVE: We investigated the association between skeletal muscle mass and dietary protein intake, habitual physical activity, body composition, and metabolic variables. METHODS: One hundred three healthy postmenopausal women from southern Brazil (age 55.2 ± 4.9 y, body mass index 27.2 ± 4.6 kg/m) were enrolled. Bone mineral density, %body fat, %trunk fat mass, and appendicular lean mass were assessed by dual-energy x-ray absorptiometry, resting metabolic rate by indirect calorimetry, and habitual physical activity by pedometer...
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922752/abnormal-glucose-metabolism-and-high-energy-expenditure-in-idiopathic-pulmonary-arterial-hypertension
#17
Gustavo A Heresi, Steven K Malin, Jarrod W Barnes, Liping Tian, John P Kirwan, Raed A Dweik
RATIONALE: Insulin resistance has emerged as a potential mechanism related to the pathogenesis of idiopathic pulmonary arterial hypertension (IPAH). However, direct measurements of insulin and glucose metabolism have not been performed in IPAH patients to date. OBJECTIVES: To perform comprehensive metabolic phenotyping on humans with IPAH. METHODS: We assessed plasma insulin and glucose using an oral glucose tolerance test and estimated insulin resistance and beta-cell function in 14 IPAH patients and 14 controls matched for age, sex, blood pressure, and body mass index (BMI),...
December 6, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27920897/impact-of-biopolymer-matrices-on-relaxometric-properties-of-contrast-agents
#18
Alfonso Maria Ponsiglione, Maria Russo, Paolo Antonio Netti, Enza Torino
Properties of water molecules at the interface between contrast agents (CAs) for magnetic resonance imaging and macromolecules could have a valuable impact on the effectiveness of metal chelates. Recent studies, indeed, demonstrated that polymer architectures could influence CAs' relaxivity by modifying the correlation times of the metal chelate. However, an understanding of the physico-chemical properties of polymer/CA systems is necessary to improve the efficiency of clinically used CAs, still exhibiting low relaxivity...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27920499/smart-nanocrystals-of-artemether-fabrication-characterization-and-comparative-in-vitro-and-in-vivo-antimalarial-evaluation
#19
Syed Muhammad Hassan Shah, Farhat Ullah, Shahzeb Khan, Syed Muhammad Mukarram Shah, Marcel de Matas, Zahid Hussain, Muhammad Usman Minhas, Naser M AbdEl-Salam, Khaled Hafez Assi, Mohammad Isreb
Artemether (ARTM) is a very effective antimalarial drug with poor solubility and consequently low bioavailability. Smart nanocrystals of ARTM with particle size of 161±1.5 nm and polydispersity index of 0.172±0.01 were produced in <1 hour using a wet milling technology, Dena(®) DM-100. The crystallinity of the processed ARTM was confirmed using differential scanning calorimetry and powder X-ray diffraction. The saturation solubility of the ARTM nanocrystals was substantially increased to 900 µg/mL compared to the raw ARTM in water (145...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27919702/design-of-pvp-va-s-630-based-tadalafil-solid-dispersion-to-enhance-the-dissolution-rate
#20
Jin-Seok Choi, Jeong-Sook Park
Tadalafil (TDF) is a Biopharmaceutics Classification System (BCS) class II drug; the efficacy thereof is critically limited by inherent poor water solubility. Solid dispersion (SD) techniques are widely used to improve the bioavailability of drugs that are poorly water-soluble. Herein, we used an SD technique to improve the solubility and in vitro dissolution rate of TDF; a solvent evaporation method was applied involving the use of hydrophilic carriers (PVP/VA S-630) and assistants (malic acid or meglumine)...
December 2, 2016: European Journal of Pharmaceutical Sciences
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