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https://www.readbyqxmd.com/read/29148063/studies-on-the-curcumin-phospholipid-complex-solidified-with-soluplus-%C3%A2
#1
Jianan Wang, Lulu Wang, Lan Zhang, Dandan He, Jianming Ju, Weiguang Li
OBJECTIVES: With the purpose of developing a curcumin phospholipid complex (CPC) formulation with high performance, the CPC was prepared and solidified with Soluplus(®) in this study. METHODS: Soluplus(®) was used as a carrier to solidify CPC. The structures of the CPC and curcumin phospholipid complex - Soluplus(®) solidified powder (CSP) - were also characterized by differential scanning electron microscope, differential scanning calorimetry, Fourier transform infrared spectroscopy and X-ray diffractometer, and flowability, in-vitro dissolution and oral bioavailability were also investigated...
November 17, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29147872/fluidized-bed-hot-melt-granulation-as-a-tool-to-improve-curcuminoid-solubility
#2
Cristiane C C Teixeira, Elias de Paiva Junior, Luis Alexandre Pedro de Freitas
Curcumin is the main bioactive component of Curcuma longa L. and has recently aroused growing interest from the scientific community. Unfortunately, the medicinal properties attributed to curcuminoids are impaired by their low oral bioavailability or low solubility in aqueous solutions. Many strategies have been studied to improve curcumin solubility; however, the preparation of granules using hydrophilic materials has never been attempted. The aim of this work was to develop curcumin granules by fluidized bed hot-melt granulation using the hydrophilic carrier Gelucire® 50:13...
November 16, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29146539/hyaluronan-decorated-liposomes-as-drug-delivery-systems-for-cutaneous-administration
#3
Silvia Franzé, Alessandro Marengo, Barbara Stella, Paola Minghetti, Silvia Arpicco, Francesco Cilurzo
The work aimed to evaluate the feasibility to design hyaluronic acid (HA) decorated flexible liposomes to enhance the skin penetration of nifedipine. Egg phosphatidylcholine (e-PC) based transfersomes (Tween 80) and transethosomes (ethanol) were prepared. HA was reacted with 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (HA-DPPE) and two molar ratios (0.5 and 3%) of conjugate with respect to e-PC were tested. The presence of HA significantly increased the packing order of the bilayer (as verified by differential scanning calorimetry), reducing both the encapsulation efficiency and the flexibility of the decorated liposomes in a dose-dependent manner...
November 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29146355/gelatinized-wheat-starch-influences-crystallization-behaviour-and-structure-of-roll-in-shortenings-in-laminated-bakery-products
#4
Kristin D Mattice, Alejandro G Marangoni
One hydrogenated and one non-hydrogenated shortening were baked with isolated components of a croissant matrix, including crystalline wheat starch, gelatinized wheat starch, gluten, and formed gluten network. The impact of the matrix components on fat crystallization was analyzed for polymorphism using powder X-ray diffraction, solid fat content by pulsed nuclear magnetic resonance and thermal behaviour by differential scanning calorimetry. When compared to results obtained from croissants prepared with the respective shortenings, samples containing gelatinized wheat starch displayed notably similar results: polymorphic conversion, from the β' to β form over storage, and visually broader peaks in the melting endotherms indicating a greater temperature was required to completely melt all of the fat...
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29145096/sulfaguanidine-cocrystals-synthesis-structural-characterization-and-their-antibacterial-and-hemolytic-analysis
#5
Syed Sibte Asghar Abidi, Yasser Azim, Shahper Nazeer Khan, Asad U Khan
Sulfaguanidine (SG), belongs to the class of sulfonamide drug used as an effective antibiotic. In the present work, using crystal engineering approach two novel cocrystals of SG were synthesized (SG-TBA and SG-PT) with thiobarbutaric acid (TBA) and 1,10-phenanthroline (PT), characterized by solid state techniques viz., powder X-ray diffraction (PXRD), fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and the crystal structures were determined by single crystal X-ray diffraction studies...
November 11, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29144761/amphiphiles-without-head-and-tail-design-nanostructures-based-on-the-self-assembly-of-anionic-boron-cluster-compounds
#6
Roberto Fernandez-Alvarez, Vladimír Ďorďovič, Mariusz Uchman, Pavel Matejicek
Anionic boron hydride cluster compounds (ABCCs) are intrinsically amphiphilic building blocks suitable for nanochemistry. ABCCs are involved in atypical weak interactions, notably dihydrogen bonding, due to their peculiar polyhedral structure, consisting of negatively charged B-H units. The most striking feature of ABCCs that differentiates them from typical surfactants is the lack of head-and-tail structure. Furthermore, their structure can be described as intrinsically amphiphilic or aquaneutral. Therefore, classical terms established to describe self-assembly of classical amphiphiles are insufficient and need to be reconsidered...
November 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29140679/a-green-approach-to-improving-the-strength-and-flame-retardancy-of-poly-vinyl-alcohol-clay-aerogels-incorporating-bio-based-gelatin
#7
Yu-Tao Wang, Hai-Bo Zhao, Kimberly C Degracia, Lin-Xuan Han, Hua Sun, Mingze Sun, Yu-Zhong Wang, David A Schiraldi
Bio-based gelatins were used to improve the compressive and flammability properties poly(vinyl alcohol)/montmorillonite (PVA/MMT) aerogels, fabricated using a simple and environmentally-friendly freeze-drying method. Due to the excellent compatibility and strong interfacial adhesion between PVA and gelatin, the compressive moduli of aerogels were enhanced dramatically with the incorporation of gelatin. PVA/MMT/porcine gelatin aerogels exhibit compressive modulus values as much as 12.4 MPa, nearly 300% that of the control PVA/MMT aerogel...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29140279/free-standing-and-self-crosslinkable-hybrid-films-by-core-shell-particle-design-and-processing
#8
Steffen Vowinkel, Stephen Paul, Torsten Gutmann, Markus Gallei
The utilization and preparation of functional hybrid films for optical sensing applications and membranes is of utmost importance. In this work, we report the convenient and scalable preparation of self-crosslinking particle-based films derived by directed self-assembly of alkoxysilane-based cross-linkers as part of a core-shell particle architecture. The synthesis of well-designed monodisperse core-shell particles by emulsion polymerization is the basic prerequisite for subsequent particle processing via the melt-shear organization technique...
November 15, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29140154/no-difference-in-young-adult-athletes-resting-energy-expenditure-when-measured-under-inpatient-or-outpatient-conditions
#9
Julia L Bone, Louise M Burke
Low energy availability can place athletes at increased risk of injury and illness and can be detected by a low metabolic rate. The lowest metabolic rate is captured at the bedside, after an overnight fast and termed inpatient REE. Measurements done in a laboratory with a shorter overnight fast are termed outpatient REE. Although important to know what the lowest energy expenditure, a bedside measure and/or 12 h fast is not always practical or logistically possible particularly when you take into account an athlete's training schedule...
November 15, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29139146/effects-of-the-sodium-glucose-cotransporter-2-sglt2-inhibitor-velagliflozin-a-new-drug-with-therapeutic-potential-to-treat-diabetes-in-cats
#10
M Hoenig, M Clark, D J Schaeffer, D Reiche
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are used in the treatment of human diabetics. They increase glucose excretion and correct hyperglycemia. We examined the investigational SGLT2 inhibitor velagliflozin in two groups of six neutered adult obese cats (equal gender distribution). Placebo (Pl) or drug (D; 1 mg/kg) was administered for 35 days. Routine blood examinations, fructosamine, beta-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), glucagon, adiponectin, and leptin were measured before and after treatment, also water intake, and urinary electrolytes, glucose, and volume...
November 15, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29138563/squarticles-as-the-nanoantidotes-to-sequester-the-overdosed-antidepressant-for-detoxification
#11
Chun-Han Chen, Tse-Hung Huang, Ahmed O Elzoghby, Pei-Wen Wang, Chia-Wen Chang, Jia-You Fang
The increasing death rate caused by drug overdose points to an urgent demand for the development of novel detoxification therapy. In an attempt to detoxify tricyclic antidepressant overdose, we prepared a lipid nanoemulsion, called squarticles, as the nanoantidote. Squalene was the major lipid matrix of the squarticles. Here, we present the animal study to investigate both the pharmacokinetic and pharmacodynamic effects of squarticles on amitriptyline intoxication. The anionic and cationic squarticles had average diameters of 97 and 122 nm, respectively...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29138259/spectroscopic-and-calorimetric-characterization-of-spermine-oxidase-and-its-association-forms
#12
Alessia Leonetti, Laura Cervoni, Fabio Polticelli, Yuta Kanamori, Zuleyha Nihan Yurtsever, Enzo Agostinelli, Paolo Mariottini, Pasquale Stano, Manuela Cervelli
Spermine oxidase (SMOX) is a flavin-containing enzyme that oxidizes spermine to produce spermidine, 3-aminopropanaldehyde and hydrogen peroxide. SMOX has been shown to play key roles in inflammation and carcinogenesis; indeed it is differentially expressed in several human cancer types. Our previous investigation has revealed that SMOX purified after heterologous expression in Escherichia coli actually consists of monomers, covalent homodimers, and other higher-order forms. All association forms oxidise spermine and, after treatment with DTT, revert to SMOX monomer...
November 14, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29137793/co-treatment-of-spent-cathode-carbon-in-caustic-and-acid-leaching-process-under-ultrasonic-assisted-for-preparation-of-sic
#13
Jie Yuan, Jin Xiao, Fachuang Li, Bingjie Wang, Zhen Yao, Bailie Yu, Liuyun Zhang
Spent cathode carbon (SCC) from aluminum electrolysis has been treated in ultrasonic-assisted caustic leaching and acid leaching process, and purified SCC used as carbon source to synthesize silicon carbide (SiC) was investigated. Chemical and mineralogical properties have been characterized by X-ray diffraction (XRD), X-ray fluorescence (XRF), scanning electron microscopy (SEM), and thermogravimetry and differential scanning calorimetry (TGA-DSC). Various experimental factors temperature, time, liquid-solid ratio, ultrasonic power, and initial concentration of alkali or acid affecting on SCC leaching result were studied...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29136285/characterization-and-oxidative-stability-of-purslane-seed-oil-microencapsulated-in-yeast-cells-biocapsules
#14
Maryam Kavosi, Abdorreza Mohammadi, Saeedeh Shojaee-Aliabadi, Ramin Khaksar, Seyede Marzieh Hosseini
BACKGROUND: Purslane seed oil, as a potential nutritious source of omega-3 fatty acid, is susceptible to oxidation. Encapsulation in yeast cells is a possible approach for overcoming this problem. In the present study, purslane seed oil was encapsulated in non-plasmolysed, plasmolysed and plasmolysed carboxy methyl cellulose (CMC)-coated Saccharomyces cerevisiae cells and measurements of oil loading capacity (LC), encapsulation efficiency (EE), oxidative stability and the fatty acid composition of oil-loaded microcapsules were made...
November 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29134744/acute-oral-sodium-propionate-supplementation-raises-resting-energy-expenditure-and-lipid-oxidation-in-fasted-humans
#15
Edward S Chambers, Claire S Byrne, Karen Aspey, Yanjie Chen, Saadiyah Khan, Douglas J Morrison, Gary Frost
Short chain fatty acids (SCFAs), produced from fermentation of dietary fibre by the gut microbiota, have been suggested to modulate energy metabolism. Previous work using rodent models have demonstrated that oral supplementation of the SCFA propionate raises resting energy expenditure (REE) by promoting lipid oxidation. The objective of this study was to investigate the effects of oral sodium propionate on REE and substrate metabolism in humans. Eighteen healthy volunteers (9 females and 9 males; Age: 25±1 y; Body Mass Index: 24...
November 13, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29133854/copper-ii-binding-of-nad-p-h-flavin-oxidoreductase-nfor-enhances-its-cr-vi-reducing-ability
#16
Huawen Han, Zhenmin Ling, Tuoyu Zhou, Rong Xu, Yongxing He, Pu Liu, Xiangkai Li
Microbes can reduce hexavalent chromium Cr (VI) to the less toxic and soluble trivalent Cr (III). Copper stimulates microbial reduction of Cr (VI) by the Bacillus, Ochrobactrum, and Gluconobacter species; however, the mechanism remains unclear. In our study, the rate of Cr (VI) reduction by Staphylococcus aureus LZ-01 was increased by 210 % when supplemented with 60 μM Cu (II). A putative NAD(P)H-flavin oxidoreductase gene (nfoR) was upregulated under Cr (VI) stress. NfoR-knockout mutant displayed impaired reduction of Cr (VI) and Cu (II)-enhanced Cr (VI) reduction by nfoR isogenic mutant was attenuated in the presence of Cu (II)...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133527/interaction-of-the-phosphorylated-dna-binding-domain-in-nuclear-receptor-car-with-its-ligand-binding-domain-regulates-car-activation
#17
Ryota Shizu, Jungki Min, Mack Sobhany, Lars C Pedersen, Shingo Mutoh, Masahiko Negishi
The nuclear protein constitutive active/androstane receptor (CAR or NR1I3) regulates several liver functions such as drug and energy metabolism and cell growth or death, which are often involved in the development of diseases such as diabetes and hepatocellular carcinoma. CAR undergoes a conversion from inactive homodimers to active heterodimers with retinoid X receptor alpha (RXRα), and phosphorylation of the DNA-binding domain (DBD) at Thr-38 in CAR regulates this conversion. Here, we uncovered the molecular mechanism by which this phosphorylation regulates the intramolecular interaction between CARs DBD and ligand-binding domain (LBD), enabling the homodimer-heterodimer conversion...
November 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29133233/freeze-drying-from-organic-co-solvent-systems-part-1-thermal-analysis-of-co-solvent-based-placebo-formulations-in-the-frozen-state
#18
Claudia Kunz, Sonja Schuldt-Lieb, Henning Gieseler
The use of co-solvent systems has been demonstrated to shorten lengthy freeze drying processes and improve the solubility and stability of certain active pharmaceutical ingredients. The goal of the present study was to evaluate the suitability of two thermal characterization techniques, differential scanning calorimetry and freeze dry microscopy, to identify an optimal co-solvent system. Binary mixtures of a co-solvent (tert-butanol, dimethyl sulfoxide, 1,4-dioxane, acetone or ethanol) and water were investigated...
November 10, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29133204/investigating-phase-separation-in-amorphous-solid-dispersions-via-raman-mapping
#19
Christian Luebbert, Christian Klanke, Gabriele Sadowski
The bioavailability of poorly-water-soluble active pharmaceutical ingredients (APIs) can be significantly improved by so-called amorphous solid dispersions (ASDs). However, the long-term stability of ASDs might be impaired by API recrystallization and/or amorphous phase separation (APS). So far, no methods have been reported to quantify APS in ASDs. In this work, phase-separation kinetics as well as the compositions of the two amorphous phases evolving due to APS were quantitatively determined for the first time using confocal Raman spectroscopy...
November 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29132840/d-peptides-as-inhibitors-of-pr3-membrane-interactions
#20
Ksenia Maximova, Tom Venken, Nathalie Reuter, Joanna Trylska
Proteinase 3 (PR3) is a neutrophil serine protease present in cytoplasmic granules but also expressed at the neutrophil surface where it mediates proinflammatory effects. Studies of the underlying molecular mechanisms have been hampered by the lack of inhibitors of the PR3 membrane anchorage. Indeed while there exist inhibitors of the catalytic activity of PR3, its membrane interfacial binding site (IBS) is distinct from its catalytic site. The IBS has been characterized both by mutagenesis experiments and molecular modeling...
November 10, 2017: Biochimica et Biophysica Acta
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