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https://www.readbyqxmd.com/read/28724250/reuse-water-exposure-duration-seasonality-and-treatment-affect-tissue-responses-in-a-model-fish
#1
B J Blunt, A Singh, L Wu, M Gamal El-Din, M Belosevic, K B Tierney
Partially remediated gray (reuse) water will likely find increasing use in a variety of applications owing to the increasing scarcity of freshwater. We aimed to determine if a model fish, the goldfish, could sense reuse water using olfaction (smell), and if 30min or 7d (acute) and 60d (sub-chronic) exposures would affect their olfactory responses to natural odorants. We examined olfaction as previous studies have found that numerous chemicals can impair the olfactory sense, which is critical to carrying out numerous life-sustaining behaviors from feeding to mating...
July 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724220/influence-of-temperature-in-pollution-induced-community-tolerance-approaches-used-to-assess-effects-of-copper-on-freshwater-phototrophic-periphyton
#2
Anne Sophie Lambert, Aymeric Dabrin, Arnaud Foulquier, Soizic Morin, Christophe Rosy, Marina Coquery, Stéphane Pesce
By measuring levels of tolerance to toxicants in microbial communities using functional toxicity tests under controlled conditions, pollution-induced community tolerance (PICT) approaches offer an effect-based tool to assess the ecological risk of chemicals in aquatic systems. However, induced tolerance of exposed microbial communities cannot always be attributed solely to the presence of toxicants as various environmental factors, such as temperature, can also be involved. Several PICT studies have been conducted to assess the effects of copper (Cu) on phototrophic periphyton, but little is known about the influence of temperature on the response of these microbial communities to acute and chronic exposure to Cu...
July 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724203/huprine-x-attenuates-the-neurotoxicity-induced-by-kainic-acid-especially-brain-inflammation
#3
J Relat, B Pérez, P Camps, D Muñoz-Torrero, A Badia, M V Clos
Huprine X (HX) is a synthetic anticholinesterasic compound that exerts a potent inhibitory action on acetylcholinesterase (AChE) activity, an agonist effect on cholinergic receptors, neuroprotective activity in different neurotoxicity models in vivo and in vitro and cognition enhancing effects in non-transgenic (C57BL/6) and transgenic (3xTg-AD, APPswe) mice. In the present study, we assessed the ability of HX (0.8 mg/kg, 21 days) to prevent the damage induced by kainic acid (KA; 28 mg/kg) regarding apoptosis, glia reactivity and neurogenesis in mouse brain...
July 19, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28724175/myo-inositol-and-selenium-reduce-the-risk-of-developing-overt-hypothyroidism-in-patients-with-autoimmune-thyroiditis
#4
S M Ferrari, P Fallahi, F Di Bari, R Vita, S Benvenga, A Antonelli
OBJECTIVE: The beneficial effects obtained by myo-inositol in association with seleno-methionine in patients affected by subclinical hypothyroidism have been recently demonstrated. Here, we evaluate the immune-modulating effect of myo-inositol in association with seleno-methionine in patients with euthyroid autoimmune thyroiditis (AT). PATIENTS AND METHODS: Twenty-one consecutive Caucasian patients with newly diagnosed euthyroid chronic AT were evaluated. All subjects were treated with myo-inositol in association with selenium (600 mg/83 mg) tablets, twice per day, for six months...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28724049/hepatitis-b-status-in-hemodialysis-patients
#5
Maia Nogueira Crown Guimarães, Tila Facincani, Sigrid De Sousa Dos Santos
BACKGROUND: Patients on chronic dialysis present a high prevalence of hepatitis B virus infection. Despite infection-control practices, surveillance of serological markers, and hepatitis B vaccination, there are still outbreaks of the disease in dialysis centers. OBJECTIVE: This study aims to assess the serologic and vaccination status for hepatitis B in hemodialysis patients. METHODS: This cross-sectional study assessed serologic markers and hepatitis B vaccination status of chronic kidney disease patients on regular dialysis program in São Carlos, SP, Brazil...
July 13, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28724043/compulsory-notification-at-skilled-nursing-facilities
#6
Milton Luiz Gorzoni, Márcia Regina Valadares Aguado, Sueli Luciano Pires, Lilian de Fátima Costa Faria
Introduction: Notifiable diseases (NDs) encompass conditions of high clinical severity and/or contagious. Being closed communities, long-term care facilities (LTCF) are places that deserve attention on their own, but one might be left wondering: what is the reality of NDs at Brazilian LTCFs? Objective: To determine the prevalence and type of NDs at large LTCF. Method: Active search for NDs conducted by the Hospital Infection Control Committee (HICC) in 459 beds...
May 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28724036/clinical-pharmacology-profile-of-care-in-hepatology-clinic
#7
Talita Rocha Passos, Fabiana Silva Santos, Maria Cleusa Martins, Vanusa Barbosa Pinto, Flair José Carrilho, Suzane Kioko Ono
Since 2010, the Clinical Gastroenterology and Hepatology Division of the Central Institute of Hospital das Clínicas of the University of São Paulo Medical School (HC-FMUSP, in the Portuguese acronym) has been developing specialized electives assistance activities in the Outpatient Specialty Clinic, Secondary Level, in São Paulo NGA-63 Várzea do Carmo. The objective of this study was to analyze the pharmacotherapeutic profile of patients. This is a cross-sectional and retrospective study in which patients were seen at the Hepatology sector and the results were submitted to descriptive statistics...
May 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28723979/outcome-and-nutritional-assessment-of-chronic-liver-disease-patients-using-anthropometry-and-subjective-global-assessment
#8
Gonçalo Nunes, Carla Adriana Santos, Rita Barosa, Cristina Fonseca, Ana Teresa Barata, Jorge Fonseca
BACKGROUND: Protein-calorie malnutrition is common in chronic liver disease (CLD) but adequate clinical tools for nutritional assessment are not defined. OBJECTIVE: In CLD patients, it was aimed: 1. Characterize protein-calorie malnutrition; 2. Compare several clinical, anthropometric and functional tools; 3. Study the association malnutrition/CLD severity and malnutrition/outcome. METHODS: Observational, prospective study. Consecutive CLD ambulatory/hospitalised patients were recruited from 01-03-2012 to 31-08-2012, studied according with age, gender, etiology, alcohol consumption and CLD severity defined by Child-Turcotte-Pugh...
July 6, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28723961/dysfunctional-gpr40-ffar1-signaling-exacerbates-pain-behavior-in-mice
#9
Kazuo Nakamoto, Fuka Aizawa, Kei Miyagi, Takuya Yamashita, Mitsumasa Mankura, Yutaka Koyama, Fumiyo Kasuya, Akira Hirasawa, Takashi Kurihara, Atsuro Miyata, Shogo Tokuyama
We previously showed that activation of G protein-coupled receptor 40/free fatty acid receptor 1 (GPR40/FFAR1) signaling modulates descending inhibition of pain. In this study, we investigated the involvement of fatty acid-GPR40/FFAR1 signaling in the transition from acute to chronic pain. We used GPR40/FFAR1-knockout (GPR40KO) mice and wild-type (WT) mice. A plantar incision was performed, and mechanical allodynia and thermal hyperalgesia were evaluated with a von Frey filament test and plantar test, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28723954/association-between-urinary-biomarkers-of-total-sugars-intake-and-measures-of-obesity-in-a-cross-sectional-study
#10
Rachel Campbell, Natasha Tasevska, Kim G Jackson, Virag Sagi-Kiss, Nick di Paolo, Jennifer S Mindell, Susan J Lister, Kay-Tee Khaw, Gunter G C Kuhnle
Obesity is an important modifiable risk factor for chronic diseases. While there is increasing focus on the role of dietary sugars, there remains a paucity of data establishing the association between sugar intake and obesity in the general public. The objective of this study was to investigate associations of estimated sugar intake with odds for obesity in a representative sample of English adults. We used data from 434 participants of the 2005 Health Survey of England. Biomarkers for total sugar intake were measured in 24 h urine samples and used to estimate intake...
2017: PloS One
https://www.readbyqxmd.com/read/28723939/assessing-health-related-resiliency-in-hiv-latin-women-preliminary-psychometric-findings
#11
Gladys J Jimenez-Torres, Valerie Wojna, Ernesto Rosario, Rosa Hechevarría, Ada M Alemán-Batista, Miriam Ríos Matos, Alok Madan, Richard L Skolasky, Summer F Acevedo
BACKGROUND: HIV-associated vulnerabilities-especially those linked to psychological issues-and limited mental health-treatment resources have the potential to adversely affect the health statuses of individuals. The concept of resilience has been introduced in the literature to shift the emphasis from vulnerability to protective factors. Resilience, however, is an evolving construct and is measured in various ways, though rarely among underserved, minority populations. Herein, we present the preliminary psychometric properties of a sample of HIV-seropositive Puerto Rican women, measured using a newly developed health-related resilience scale...
2017: PloS One
https://www.readbyqxmd.com/read/28723914/safety-and-pharmacodynamics-of-dalazatide-a-kv1-3-channel-inhibitor-in-the-treatment-of-plaque-psoriasis-a-randomized-phase-1b-trial
#12
Eric J Tarcha, Chelsea M Olsen, Peter Probst, David Peckham, Ernesto J Muñoz-Elías, James G Kruger, Shawn P Iadonato
BACKGROUND: Dalazatide is a specific inhibitor of the Kv1.3 potassium channel. The expression and function of Kv1.3 channels are required for the function of chronically activated memory T cells, which have been shown to be key mediators of autoimmune diseases, including psoriasis. OBJECTIVE: The primary objective was to evaluate the safety of repeat doses of dalazatide in adult patients with mild-to-moderate plaque psoriasis. Secondary objectives were to evaluate clinical proof of concept and the effects of dalazatide on mediators of inflammation in the blood and on chronically activated memory T cell populations...
2017: PloS One
https://www.readbyqxmd.com/read/28723905/evolution-of-anti-trypanosoma-cruzi-antibody-production-in-patients-with-chronic-chagas-disease-correlation-between-antibody-titers-and-development-of-cardiac-disease-severity
#13
Ingebourg Georg, Alejandro Marcel Hasslocher-Moreno, Sergio Salles Xavier, Marcelo Teixeira de Holanda, Eric Henrique Roma, Maria da Gloria Bonecini-Almeida
Chagas disease is one of the most important endemic infections in Latin America affecting around 6-7 million people. About 30-50% of patients develop the cardiac form of the disease, which can lead to severe cardiac dysfunction and death. In this scenario, the identification of immunological markers of disease progression would be a valuable tool for early treatment and reduction of death rates. In this observational study, the production of anti-Trypanosoma cruzi antibodies through a retrospective longitudinal follow-up in chronic Chagas disease patients´ cohort and its correlation with disease progression and heart commitment was evaluated...
July 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28723879/suppression-of-sympathetic-nerve-sprouting-by-local-administration-of-an-%C3%AE-antagonist-around-the-dorsal-root-ganglion-in-a-lumbar-radiculopathy-model
#14
Izaya Ogon, Tsuneo Takebayashi, Tsuyoshi Miyakawa, Takehito Iwase, Katsumasa Tanimoto, Yoshinori Terashima, Syunsuke Jimbo, Takeshi Kobayashi, Noritsugu Tohse, Toshihiko Yamashita
STUDY DESIGN: Animal experimental study with intervention OBJECTIVE.: The purpose of this study was to elucidate whether local administration of an α-antagonist around the dorsal root ganglion (DRG) suppressed sympathetic nerve sprouting, from the acute to the chronic pain development phase, in a lumbar radiculopathy model using immunohistochemical methods. SUMMARY OF BACKGROUND DATA: The abnormal sympathetic-somatosensory interaction may underlie some forms of neuropathic pain...
July 18, 2017: Spine
https://www.readbyqxmd.com/read/28723869/chronic-disseminated-salmonellosis-in-a-patient-with-interleukin-12p40-deficiency
#15
Emadia Mohammad Alaki, Fahad Aljobair, Faisal Alaklobi, Mobarak Al Shamrani, Fahad Al-Zahim, Aziza Dongues, Jean-Laurent Casanova
Interleukin (IL)-12 is composed of p35 and p40 subunit, in this case IL-12p40 deficiency is a rare genetic etiology of Mendelian susceptibility to mycobacterial disease (MSMD). Salmonellosis has been reported in almost half of these patients and mostly present in recurrent extra intestinal form. In this report, we described an 18 month old boy with absence of IL12p40 production suffering from chronic disseminated non-typhoidal salmonellosis. To the best of our knowledge this is the first reported case.
July 18, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28723862/risk-of-colorectal-cancer-in-chronic-kidney-disease-a-systematic-review-and-meta-analysis
#16
Yuga Komaki, Fukiko Komaki, Dejan Micic, Akio Ido, Atsushi Sakuraba
BACKGROUND: Association between chronic kidney disease and colorectal cancer (CRC) remains unclear. GOALS: To assess the risk of CRC in patients with various chronic kidney diseases before and after kidney transplantation. STUDY: Electronic databases were searched for cohort studies assessing the risk of CRC in patients with chronic kidney diseases. The primary outcome was the risk of CRC among studies that reported the risk as standardized incidence rate (SIR)...
July 18, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28723855/four-year-outcomes-after-cessation-of-tenofovir-in-immune-tolerant-chronic-hepatitis-b-patients
#17
Vincent Wai-Sun Wong, Aric J Hui, Grace Lai-Hung Wong, Rosita Suk-Yi Chan, Angel Mei-Ling Chim, Angeline Oi-Shan Lo, Henry Lik-Yuen Chan
GOALS: To study the long-term outcome after cessation of antiviral therapy in immune-tolerant patients. BACKGROUND: Experience in the treatment of immune-tolerant chronic hepatitis B is scanty. Some immune-tolerant patients may receive temporary antiviral therapy, such as for prevention of vertical transmission at pregnancy or prophylaxis for chemotherapy. STUDY: This was a follow-up study of a phase 2 trial at 2 centers. Immune-tolerant patients received tenofovir disoproxil fumarate and/or emtricitabine for 4 years and were followed for another 4 years after treatment cessation...
July 18, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28723848/progression-of-macular-atrophy-in-eyes-with-type-1-neovascularization-and-age-related-macular-degeneration-receiving-long-term-intravitreal-anti-vascular-endothelial-growth-factor-therapy-an-optical-coherence-tomographic-angiography-analysis
#18
Joseph G Christenbury, Nopasak Phasukkijwatana, Fatimah Gilani, K Baily Freund, SriniVas Sadda, David Sarraf
PURPOSE: To evaluate the size and location of macular atrophy in eyes with Type-1 neovascularization (NV) and age-related macular degeneration receiving chronic intravitreal anti-vascular endothelial growth factor therapy. METHODS: A retrospective review of a case series of 27 eyes with Type-1 NV and retinal pigment epithelial detachment (PED) having a minimum of 12 months follow-up was performed. Demographic information and visual acuity at baseline and the final follow-up were collected...
July 18, 2017: Retina
https://www.readbyqxmd.com/read/28723801/multidisciplinary-approach-and-long-term-follow-up-in-a-series-of-640-consecutive-patients-with-sarcoidosis-cohort-study-of-a-40-year-clinical-experience-at-a-tertiary-referral-center-in-barcelona-spain
#19
Juan Mañá, Manuel Rubio-Rivas, Nadia Villalba, Joaquim Marcoval, Adriana Iriarte, María Molina-Molina, Roger Llatjos, Olga García, Sergio Martínez-Yélamos, Vanessa Vicens-Zygmunt, Cristina Gámez, Ramón Pujol, Xavier Corbella
Cohort studies of large series of patients with sarcoidosis over a long period of time are scarce. The aim of this study is to report a 40-year clinical experience of a large series of patients at Bellvitge University Hospital, a tertiary university hospital in Barcelona, Spain. Diagnosis of sarcoidosis required histological confirmation except in certain specific situations. All patients underwent a prospective study protocol. Clinical assessment and follow-up of patients were performed by a multidisciplinary team...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723794/thrombosis-and-antiphospholipid-antibody-syndrome-during-acute-q-fever-a-cross-sectional-study
#20
Matthieu Million, Nathalie Bardin, Simon Bessis, Nadia Nouiakh, Charlaine Douliery, Sophie Edouard, Emmanouil Angelakis, Annick Bosseray, Olivier Epaulard, Stéphanie Branger, Bernard Chaudier, Karine Blanc-Laserre, Nicole Ferreira-Maldent, Elisa Demonchy, France Roblot, Jacques Reynes, Felix Djossou, Camelia Protopopescu, Patrizia Carrieri, Laurence Camoin-Jau, Jean-Louis Mege, Didier Raoult
Q fever is a neglected and potentially fatal disease. During acute Q fever, antiphospholipid antibodies are very prevalent and have been associated with fever, thrombocytopenia, acquired heart valve disease, and progression to chronic endocarditis. However, thrombosis, the main clinical criterion of the 2006 updated classification of the antiphospholipid syndrome, has not been assessed in this context. To test whether thrombosis is associated with antiphospholipid antibodies and whether the criteria for antiphospholipid syndrome can be met in patients with acute Q fever, we conducted a cross-sectional study at the French National Referral Center for Q fever...
July 2017: Medicine (Baltimore)
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