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https://www.readbyqxmd.com/read/28437773/are-hospital-emergency-department-visits-due-to-dog-bites-associated-with-ambient-temperature-a-time-series-study-in-beijing-china
#1
Yongming Zhang, Qi Zhao, Wenyi Zhang, Shanshan Li, Gongbo Chen, Zhihai Han, Yuming Guo
BACKGROUND: It is well documented that suboptimal ambient temperature is associated with cardiovascular and respiratory diseases. However, no study has examined the relation between temperature and dog bites. OBJECTIVES: To study the association between ambient temperature and daily hospital emergency department visits due to dog bites (EDVDBs) in Beijing, China; and to explore whether the temperature-EDVDB association varies by sex and age. METHODS: Daily EDVDBs were collected from a hospital appointed for dog bites in Beijing during 2012-2014...
April 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28437410/how-to-build-a-dog
#2
Lyudmila Trut, Lee Alan Dugatkin
No abstract text is available yet for this article.
April 18, 2017: Scientific American
https://www.readbyqxmd.com/read/28437267/reconstruction-of-pediatric-scalp-avulsion-injuries-after-dog-bites
#3
Zhi Yang Ng, Kyle R Eberlin, Tianyu Lin, Peter T Masiakos, Curtis L Cetrulo
Dog bite injuries are common and the head and neck is most frequently involved in pediatric patients. In severe cases, the combination of crushing, tearing, and puncturing can result in scalp avulsion. Currently, microsurgical replantation of the avulsed scalp remains the gold standard but may not always be possible. The authors present their treatment algorithm with 2 patient examples. In Patient 1, the scalp was deemed unsuitable for replantation due to extensive soft tissue injury; in Patient 2, the scalp was not available on presentation...
April 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28436129/use-of-an-electronic-brachytherapy-surface-applicator-to-treat-an-epiglottal-fibrosarcoma-in-a-dog
#4
Charles A Maitz, Katherine L Robinson
Presented is the case of an epiglottal fibrosarcoma in a dog. The location of the mass resulted in challenges in the delivery of adequate dose to the tumor, and herein we describe the treatment using an electronic brachytherapy source. The treatment consisted of four Gy fractions, twice daily for a total of 10 fractions (40 Gy total). Visual reevaluation two weeks after treatment supported adequate spatial dose delivery, and the patient was reportedly improved six weeks after treatment. We demonstrate that plesiotherapy using an electronic brachytherapy device is feasible and may be useful in the treatment of carefully selected veterinary tumors...
April 23, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28435836/the-comparative-diagnostic-features-of-canine-and-human-lymphoma
#5
Davis M Seelig, Anne C Avery, E J Ehrhart, Michael A Linden
The non-Hodgkin lymphomas (NHLs) are a heterogeneous family of lymphoid malignancies that are among the most common neoplasms of both dogs and humans. Owing to shared molecular, signaling, incidence, and pathologic features, there is a strong framework supporting the utilization of canine lymphoma as a comparative, large animal model of human NHL. In alignment with the biologic similarities, the current approach towards the diagnosis and classification of canine lymphoma is based upon the human World Health Organization guidelines...
June 2016: Veterinary Sciences
https://www.readbyqxmd.com/read/28435220/formulation-release-characteristics-and-bioavailability-study-of-gastroretentive-floating-matrix-tablet-and-floating-raft-system-of-mebeverine-hcl
#6
Mohamed A El Nabarawi, Mahmoud H Teaima, Rehab A Abd El-Monem, Nagla A El Nabarawy, Dalia A Gaber
To prolong the residence time of dosage forms within the gastrointestinal tract until all drug is released at the desired rate is one of the real challenges for oral controlled-release drug delivery systems. This study was designed to develop a controlled-release floating matrix tablet and floating raft system of Mebeverine HCl (MbH) and evaluate different excipients for their floating behavior and in vitro controlled-release profiles. Oral pharmacokinetics of the optimum matrix tablet, raft system formula, and marketed Duspatalin(®) 200 mg retard as reference were studied in beagle dogs...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28435196/hemato-biochemical-alterations-and-urinalysis-in-dogs-suffering-from-benign-prostatic-hyperplasia
#7
M R Das, R C Patra, R K Das, P K Rath, B P Mishra
AIM: The study was designed to evaluate the hemato-biochemical alterations, urinalysis along with histomorphological and histological changes of prostate glands in dogs affected with benign prostatic hyperplasia (BPH) in and around Bhubaneswar, Odisha, India. MATERIALS AND METHODS: In toto, 445 dogs presented to the Teaching Veterinary Clinical Complex of the College of Veterinary Sciences and Animal Husbandry, one Government Veterinary Hospital and two pet clinics in and around Bhubaneswar screened for the presence of BPH...
March 2017: Veterinary World
https://www.readbyqxmd.com/read/28434969/translational-science-approach-for-assessment-of-cardiovascular-effects-and-proarrhythmogenic-potential-of-the-beta-3-adrenergic-agonist-mirabegron
#8
Cees Korstanje, Masanori Suzuki, Koichiro Yuno, Shuichi Sato, Masashi Ukai, Marlowe J Schneidkraut, Gan X Yan
INTRODUCTION: Translational assessment of cardiac safety parameters is a challenge in clinical development of beta-3 adrenoceptor agonists. The preclinical tools are presented that were used for assessing human safety for mirabegron. METHODS: Studies were performed on electrical conductance at ion channels responsible for cardiac repolarization (IKr, IKs, Ito, INa, and ICa,L), on QT-interval, subendocardial APD90, Tpeak-end interval, and arrhythmia's in ventricular dog wedge tissue in vitro and on cardiovascular function (BP, HR, and QTc) in conscious dogs...
April 20, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28434968/cardiac-contractility-correction-strategies-applied-to-telemetry-data-from-a-hesi-sponsored-consortium
#9
Emmanuel Boulay, Michael K Pugsley, Vincent Jacquemet, Alain Vinet, Michael V Accardi, Maxim Soloviev, Eric Troncy, Jennifer M Doyle, Jennifer Beck Pierson, Simon Authier
INTRODUCTION: QT has a long history of heart rate (HR) correction but limited investigations have been undertaken to assess the impact of cardiovascular parameters on left ventricular (LV) contractility in drug safety testing. Cardiac contractility is affected by preload (Cyon-Frank-Starling law), afterload (Anrep effect) and HR (Bowditch effect). We evaluated multi-parameter correction methods to help with dP/dtmax interpretation. METHODOLOGY: Modeling was undertaken using data from dogs in single or double 4×4 Latin square studies...
April 20, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28433933/functional-foods-in-pet-nutrition-focus-on-dogs-and-cats
#10
REVIEW
Alessandro Di Cerbo, Julio Cesar Morales-Medina, Beniamino Palmieri, Federica Pezzuto, Raffaella Cocco, Gonzalo Flores, Tommaso Iannitti
Functional foods provide health benefits if they are consumed on a regular basis as part of a varied diet. In this review, we discuss the availability and role of functional foods in pet nutrition with a focus on dogs and cats. Indeed, functional foods modify gastrointestinal physiology, promote changes in biochemical parameters, improve brain functions and may reduce or minimize the risk of developing specific pathologies. This evidence derives largely from clinical studies while only limited evidence is available from studies in dogs and cats...
April 7, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28433915/stimulation-of-the-anaerobic-digestion-of-the-dry-organic-fraction-of-municipal-solid-waste-ofmsw-with-carbon-based-conductive-materials
#11
Yan Dang, Dezhi Sun, Trevor L Woodard, Li-Ying Wang, Kelly P Nevin, Dawn E Holmes
Growth of bacterial and archaeal species capable of interspecies electron exchange was stimulated by addition of conductive materials (carbon cloth or granular activated carbon (GAC)) to anaerobic digesters treating dog food (a substitute for the dry-organic fraction of municipal solid waste (OFMSW)). Methane production (772-1428mmol vs <80mmol), volatile solids removal (78%-81% vs 54%-64%) and COD removal efficiencies (∼80% vs 20%-30%) were all significantly higher in reactors amended with GAC or carbon cloth than controls...
April 9, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28433728/vector-competence-of-amblyomma-americanum-acari-ixodidae-for-rickettsia-rickettsii
#12
Michael L Levin, Galina E Zemtsova, Lindsay F Killmaster, Alyssa Snellgrove, Lauren B M Schumacher
Rickettsia rickettsii - the etiologic agent of Rocky Mountain spotted fever (RMSF) - is widely spread across the Americas. In the US, Dermacentor spp. ticks are identified as primary vectors of R. rickettsii and Rhipicephalus sanguineus s.l. has been implicated in transmission of this pathogen in several locations in the Southwest. Conversely, ticks of the genus Amblyomma are recognized vectors of RMSF in Central and South America, but not in the US. A. americanum is one of the most aggressive human-biting ticks in the US, whose geographical range overlaps with that of reported RMSF cases...
April 12, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28433694/bacteroidales-markers-for-microbial-source-tracking-in-southeast-asia
#13
Jean Pierre Nshimyimana, Mercedes C Cruz, R Janelle Thompson, Stefan Wuertz
The island city country of Singapore served as a model to validate the use of host-associated Bacteroidales 16S rRNA gene marker assays for identifying sources of fecal pollution in the urban tropical environment of Southeast Asia. A total of 295 samples were collected from sewage, humans, domesticated animals (cats, dogs, rabbits and chicken), and wild animals (birds, monkeys and wild boars). Samples were analyzed by real time PCR using five human-associated assays (HF183-SYBR Green, HF183, BacHum, BacH and B...
April 10, 2017: Water Research
https://www.readbyqxmd.com/read/28433110/animal-models-of-wilson-disease
#14
Valentina Medici, Dominik Huster
Wilson disease (WD) is caused by ATPase copper-transporting beta (ATP7B) mutations and results in copper toxicity in liver and brain. Although the defective gene was identified in 1993, the specific mechanisms underlying copper toxicity and the remarkable phenotypic diversity of the disease are still poorly understood. Animal models harboring defects in the ATP7B homolog have helped to reveal new insights into pathomechanisms of WD. Four rodent models with ATP7B gene defects have been described - the Long-Evans Cinnamon (LEC) rat, inbred mouse models (toxic milk (tx), the Jackson Laboratory toxic milk (tx-j)), and the genetically engineered ATP7B(-/-) (knockout) mouse - all of which develop liver disease to different extents...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28432797/effects-of-levothyroxine-administration-and-withdrawal-on-the-hypothalamic-pituitary-thyroid-axis-in-euthyroid-dogs
#15
V Ziglioli, D L Panciera, G C Troy, W E Monroe, K M Boes, K R Refsal
BACKGROUND: Chronic supplementation can suppress the hypothalamic-pituitary-thyroid axis (HPTA) and make it difficult to assess thyroid function after withdrawal of levothyroxine. OBJECTIVES: To determine whether the HPTA is suppressed after levothyroxine administration in euthyroid dogs and the time required for resolution of any suppression. ANIMALS: Twenty-eight healthy euthyroid dogs. METHODS: A prospective, randomized study administering levothyroxine to euthyroid dogs for 8 weeks (group 1) or 16 weeks (group 2)...
April 22, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28432495/investigating-emotional-contagion-in-dogs-canis-familiaris-to-emotional-sounds-of-humans-and-conspecifics
#16
Annika Huber, Anjuli L A Barber, Tamás Faragó, Corsin A Müller, Ludwig Huber
Emotional contagion, a basic component of empathy defined as emotional state-matching between individuals, has previously been shown in dogs even upon solely hearing negative emotional sounds of humans or conspecifics. The current investigation further sheds light on this phenomenon by directly contrasting emotional sounds of both species (humans and dogs) as well as opposed valences (positive and negative) to gain insights into intra- and interspecies empathy as well as differences between positively and negatively valenced sounds...
April 21, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28432479/pharmacokinetics-and-efficacy-of-an-ivermectin-implant-for-long-term-prevention-of-dirofilaria-immitis-infection-in-dogs
#17
Marco Genchi, Anne Geneteau, Patrick Forget, Romain Delcombel, Claudio Genchi
An exploratory study was carried out to assess the in vivo efficacy of different prototypes of subcutaneous implants containing ivermectin (IVM) for the prevention of canine Dirofilaria immitis infection. The implants consisted of an ethylcellulose matrix containing IVM (3.0, 4.5, and 6.0 mg/implant; from 0.29 to 0.63 mg/kg bw) as active ingredient designed to release approximately 0.1 ng of IVM/mL in the plasma for at least 12 months. Six dogs were implanted on day -365. On day -12, three heartworm-free dogs were included in the study as a control group...
April 22, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28432244/taking-a-proactive-role-in-tackling-hereditary-disease-in-dogs
#18
(no author information available yet)
No abstract text is available yet for this article.
April 22, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28432234/campaign-group-issues-public-reminder-that-dogs-die-in-hot-cars
#19
(no author information available yet)
No abstract text is available yet for this article.
April 22, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28431528/diagnostic-performance-of-the-urinary-canine-calgranulins-in-dogs-with-lower-urinary-or-urogenital-tract-carcinoma
#20
Romy M Heilmann, Elizabeth A McNiel, Niels Grützner, David J Lanerie, Jan S Suchodolski, Jörg M Steiner
BACKGROUND: Onset of canine transitional cell carcinoma (TCC) and prostatic carcinoma (PCA) is usually insidious with dogs presenting at an advanced stage of the disease. A biomarker that can facilitate early detection of TCC/PCA and improve patient survival would be useful. S100A8/A9 (calgranulin A/B or calprotectin) and S100A12 (calgranulin C) are expressed by cells of the innate immune system and are associated with several inflammatory disorders. S100A8/A9 is also expressed by epithelial cells after malignant transformation and is involved in the regulation of cell proliferation and metastasis...
April 21, 2017: BMC Veterinary Research
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