keyword
MENU ▼
Read by QxMD icon Read
search

Dogs

keyword
https://www.readbyqxmd.com/read/29156583/new-paradigms-for-the-study-of-ocular-alphaherpesvirus-infections-insights-into-the-use-of-non-traditional-host-model-systems
#1
REVIEW
Matthew R Pennington, Eric C Ledbetter, Gerlinde R Van de Walle
Ocular herpesviruses, most notably human alphaherpesvirus 1 (HSV-1), canid alphaherpesvirus 1 (CHV-1) and felid alphaherpesvirus 1 (FHV-1), infect and cause severe disease that may lead to blindness. CHV-1 and FHV-1 have a pathogenesis and induce clinical disease in their hosts that is similar to HSV-1 ocular infections in humans, suggesting that infection of dogs and cats with CHV-1 and FHV-1, respectively, can be used as a comparative natural host model of herpesvirus-induced ocular disease. In this review, we discuss both strengths and limitations of the various available model systems to study ocular herpesvirus infection, with a focus on the use of these non-traditional virus-natural host models...
November 18, 2017: Viruses
https://www.readbyqxmd.com/read/29156435/more-than-a-to-b-understanding-and-managing-visitor-spatial-behaviour-in-urban-forests-using-public-participation-gis
#2
Silviya Korpilo, Tarmo Virtanen, Tiina Saukkonen, Susanna Lehvävirta
Planning and management needs up-to-date, easily-obtainable and accurate information on the spatial and social aspects of visitor behaviour in order to balance human use and impacts, and protection of natural resources in public parks. We used a web-based public participation GIS (PPGIS) approach to gather citizen data on visitor behaviour in Helsinki's Central Park in order to aid collaborative spatial decision-making. The study combined smartphone GPS tracking, route drawing and a questionnaire to examine differences between user groups in their use of formal trails, off-trail behaviour and the motivations that affect it...
November 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29155829/environmental-and-socio-demographic-individual-family-and-neighborhood-factors-associated-with-children-intestinal-parasitoses-at-iguaz%C3%A3%C2%BA-in-the-subtropical-northern-border-of-argentina
#3
Maria Romina Rivero, Carlos De Angelo, Pablo Nuñez, Martín Salas, Carlos E Motta, Alicia Chiaretta, Oscar D Salomón, Song Liang
BACKGROUND: Intestinal parasitoses are a major concern for public health, especially in children from middle and low-income populations of tropical and subtropical areas. We examined the presence and co-infection of parasites in humans as well as parasitic environmental contamination in Puerto Iguazú, Argentina. We explored the environmental and socio-demographic characteristics of the persistence of parasites in children and their environment. METHODOLOGY/PRINCIPAL FINDINGS: This cross-section survey was conducted among children population comprised into the area of the public health care centers of Iguazú during June 2013 to May 2016...
November 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29155568/discovery-of-a-novel-series-of-tankyrase-inhibitors-by-a-hybridization-approach
#4
Upendra Rao Anumala, Jo Waaler, Yves Nkizinkiko, Alexander Ignatev, Katina Lazarow, Peter Lindemann, Petter Angell Olsen, Sudarshan Murthy, Ezeogo Obaji, Alexander G Majouga, Sergey V Leonov, Jens Peter von Kries, Lari Lehtiö, Stefan Krauss, Marc Nazaré
A structure-guided hybridization approach using two privileged substructures gave instant access to a new series of tankyrase inhibitors. The identified inhibitor 16 displays high target affinity on tankyrase 1 and 2 with a biochemical and cellular IC50 values of 29 nM, 6.3 nM and 19 nM, respectively, and high selectivity towards other Poly(ADP-ribose) polymerase enzymes. The identified inhibitor shows a favorable in-vitro ADME profile as well as good oral bioavailability in mice, rats and dogs. Critical for the approach was the utilization of an appropriate linker between 1,2,4-triazole and benzimidazolone moieties, whereby a cyclobutyl linker displayed superior affinity compared to a cyclohexane and phenyl linker...
November 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29155282/seizure-liability-assessments-using-the-hippocampal-tissue-slice-comparison-of-non-clinical-species
#5
Michael V Accardi, Hai Huang, Simon Authier
INTRODUCTION: Traditionally, rat hippocampal tissue slice models are used as an in vitro electrophysiology assay to assess seizurogenic potential in early drug development despite non-clinical species-specific differences noted during in vivo seizure studies. METHODS: Hippocampal tissue slices were acutely isolated from rats, minipigs, dogs and nonhuman primates (NHP). Population spikes (PS) were evoked through stimulation of the CA3 Schaffer collateral pathway and recorded using in vitro electrophysiological techniques via an extracellular electrode placed within the CA1 stratum pyramidale cell body layer...
November 16, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29155261/the-phosphodiesterase-4-inhibitor-fcpr16-attenuates-ischemia-reperfusion-injury-in-rats-subjected-to-middle-cerebral-artery-occlusion-and-reperfusion
#6
Jiajia Chen, Hui Yu, Jiahong Zhong, Hongfang Feng, Haitao Wang, Yufang Cheng, Zhengqiang Zou, Chang Huang, Zhongzhen Zhou, Wenhua Zheng, Jiangping Xu
Current phosphodiesterase-4 (PDE4) inhibitors exert beneficial effects in central nervous system diseases via anti-inflammatory and anti-apoptotic properties, but many of them are plagued by side effects like nausea and emesis. FCPR16, a novel PDE4 inhibitor synthesized in our lab, has potential anti-inflammatory property. In the present study, we aimed to investigate the effects of FCPR16 in a rat model of ischemic stroke and evaluate its emetogenic potential. Our results showed that FCPR16 treatment improved neurological function, reduced cerebral infarct volume, and attenuated brain histological changes in rats subjected to middle cerebral artery occlusion and reperfusion (MCAO/R)...
November 16, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29154928/sequence-analysis-of-the-thrombospondin-related-adhesive-protein-gene-and-heat-shock-protein-70-of-babesia-gibsoni-isolated-from-dogs-in-nanjing-china
#7
Huan-Ran Lin, Xiao-Ting Mei, Yu-Fang Hong, Yan-Bing Zhao, Xiao-Nan Guo, De-Ji Yang, Da-Wei Yao
In this study, the thrombospondin-related adhesive protein (TRAP) gene and the heat shock protein 70 (Hsp70) gene of Babesia gibsoni isolated from the naturally infected dog in the Nanjing area were cloned and sequenced. Twenty blood samples were collected from the suspected cases of babesiosis at the animal hospital of Nanjing Agriculture University. Genomic DNA was extracted from the blood samples, and the 18S rDNAs were amplified by PCR to confirm Babesia infection. As a result, 10 cases of Babesia 18S rDNA gene amplification were positive in the 20 blood samples, confirming that the 10 cases were infected with canine Babesia...
November 14, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29154712/prognosis-for-dogs-with-stage-iii-osteosarcoma-following-treatment-with-amputation-and-chemotherapy-with-and-without-metastasectomy
#8
Hailey Turner, Bernard Séguin, Deanna R Worley, Nicole P Ehrhart, Mary H Lafferty, Stephen J Withrow, Laura E Selmic
OBJECTIVE To determine survival times of selected dogs with metastatic (stage III) osteosarcoma, whether disease-free interval (DFI) was associated with survival time after diagnosis of stage III disease (ie, stage III survival time), and whether a survival benefit of metastasectomy existed. DESIGN Retrospective case series with nested cohort study. ANIMALS 194 client-owned dogs treated for histologically confirmed appendicular osteosarcoma from 1997 through 2009. PROCEDURES Dogs were included if they had stage I or II osteosarcoma at the time of initial evaluation, had amputation of the affected appendage and ≥ 1 dose of chemotherapy afterward, and developed metastasis within the follow-up period or prior to death...
December 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29154711/recognizing-describing-and-managing-reduced-food-intake-in-dogs-and-cats
#9
Lily N Johnson, Lisa M Freeman
No abstract text is available yet for this article.
December 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29154701/minimally-invasive-treatment-of-mesenteric-arterioportal-fistulas-in-two-dogs
#10
Christina J Cocca, Chick Weisse, Allyson C Berent, Robert Rosen
CASE DESCRIPTION Two Pembroke Welsh Corgis with gastrointestinal signs including inappetence, diarrhea, lethargy, and hypersalivation were referred for evaluation. CLINICAL FINDINGS Diagnostic testing included abdominal ultrasonography and CT angiography. One patient had a cranial mesenteric artery-to-mesenteric vein fistula with multiple acquired extrahepatic portosystemic shunts. The second patient had both cranial and caudal mesenteric artery-to-mesenteric vein fistulas and multiple acquired extrahepatic portosystemic shunts...
December 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29154676/effects-of-bone-regeneration-materials-and-tooth-movement-timing-on-canine-experimental-orthodontic-treatment
#11
Ferdinand Mabula Machibya, Yiyuan Zhuang, Weizhong Guo, Dongdong You, Shan Lin, Dong Wu, Jiang Chen
OBJECTIVES: To evaluate the effects of bone regeneration materials and orthodontic tooth movement (OTM) timing on tooth movement through alveolar bone defects treated with guided bone regeneration (GBR) utilizing xenografts (Bio-Oss) and alloplast (β-TCP). MATERIALS AND METHODS: Twenty-four standard alveolar bone defects in six male beagle dogs were treated by GBR using either Bio-Oss or β-TCP (experimental), whereas the control defects were left empty. The defects were further grouped into early or late subgroups, depending on OTM timing after GBR (ie 1 month or 2 months, respectively)...
November 20, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/29154572/introduction-to-special-section-on-advanced-methodology-counseling-the-dog-to-wag-its-methodological-tail
#12
Zac E Imel, Stephanie Budge, Jesse Owen
In this article, we introduce a special section focused on the application of advanced methodologies to specific research questions in counseling psychology. The articles include applications of natural language processing, dynamic systems, mediation analyses in single studies and meta-analysis, and synthesis of qualitative research. We provide a brief overview of each article. (PsycINFO Database Record
November 2017: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/29154287/did-you-know-that-your-animals-have-consciousness
#13
P A Accorsi, E Mondo, M Cocchi
Consciousness is the greatest enigma in human history. For centuries scientists and researchers have tried to describe it without coming to conclusions. In the last years with the neurosciences development, consciousness has become the common goal of numerous studies. But consciousness has always been studied only in humans, but after "Cambridge Declaration on Consciousness" in 2012, even non-human animalsthey feel possessed of the consciousness. According to "theory Orch-OR" of Hameroff and Penrose we have conducted a study on Alaskan malamute and German shepherd to analysed a triplet of platelet fatty acids (linoleic acid; palmitic acid; arachidonic acid)...
November 14, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/29153900/clinicopathological-findings-in-sick-dogs-naturally-infected-with-leishmania-infantum-comparison-of-five-different-clinical-classification-systems
#14
A Meléndez-Lazo, L Ordeix, M Planellas, J Pastor, L Solano-Gallego
A wide spectrum of clinical and clinicopathological findings in dogs with canine leishmaniosis (CanL) due to Leishmania infantum exists. However, the majority of clinical descriptions have been published a long time ago and recent studies in Europe are almost lacking. In addition, clinical classification of sick dogs is not well-standardized, with different classification systems used by clinical and epidemiological studies, making comparison of studies a difficult task. The aims of the study were to describe the clinicopathological findings of dogs naturally infected with L...
November 10, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29153849/cutting-balloon-and-high-pressure-balloon-dilation-for-palliative-treatment-of-congenital-double-chambered-right-ventricle-and-primary-infundibular-stenosis-in-a-golden-retriever-dog
#15
Karsten E Schober, Jaylyn Rhinehart, Rebecca Kohnken, John D Bonagura
Combined cutting balloon and high-pressure balloon dilation was performed in a dog with a double-chambered right ventricle and severe infundibular stenosis of the right ventricular outflow tract. The peak systolic pressure gradient across the stenosis decreased by 65% after dilation (from 187 mmHg before to 66 mmHg after) affirming the intervention as successful. However, early re-stenosis occurred within 3 months leading to exercise intolerance, exercise-induced syncope, and right-sided congestive heart failure...
November 16, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/29153107/interictal-cardiac-autonomic-nervous-system-disturbances-in-dogs-with-idiopathic-epilepsy
#16
M Musteata, D Mocanu, G D Stanciu, M Armasu, G Solcan
Autonomic nervous system (ANS) activity in the interictal period (InIp) in dogs with presumed idiopathic epilepsy (pIE) was assessed using heart rate variability (HRV) analysis. The HRVs obtained from 28 pIE dogs with interictal epileptic discharges (InIEd; 11 with treatment and 17 without treatment) detected on electroencephalography (EEG) were compared with those obtained from 13 healthy dogs. On electrocardiographic (ECG) study, the P wave dispersion (PWD; P<0.001), P max (P=0.004) and corrected QT interval (QTc; P=0...
October 2017: Veterinary Journal
https://www.readbyqxmd.com/read/29153103/comprehensive-analysis-of-gene-expression-profiles-reveals-novel-candidates-of-chemotherapy-resistant-factors-in-canine-lymphoma
#17
Miyu Suenaga, Hirotaka Tomiyasu, Manabu Watanabe, Kotogo Ogawa, Tomoki Motegi, Yuko Goto-Koshino, Koichi Ohno, Sumio Sugano, Katherine A Skorupski, Hajime Tsujimoto
The molecular mechanisms of acquisition of chemotherapy resistance in canine lymphoma have not been elucidated. The aim of the present study was to identify novel molecular mechanisms of chemotherapy resistance by a comprehensive analysis of changes in gene expression profiles (GEPs). Tumor samples were obtained from 10 dogs with lymphoma at chemotherapy sensitive and chemotherapy resistant phases. During chemotherapy resistance, the expression of genes associated with immune responses and inflammatory reactions was decreased compared to chemotherapy sensitive phases...
October 2017: Veterinary Journal
https://www.readbyqxmd.com/read/29153102/stability-of-compounded-trilostane-suspension-in-cod-liver-oil
#18
Jesse Crosby, Stacy Brown
Trilostane is a synthetic steroid analog used to treat canine hyperadrenocorticism. For small dogs, the dose found in commercially available dosage forms of trilostane is sometimes too high. Compounding trilostane in a liquid diluent provides an option for more precise dosing and adjustments, and can be easier to administer, versus a tablet or capsule. Trilostane suspends well in cod liver oil, which is generally palatable to dogs. The stability of a compounded trilostane suspension in cod liver oil stored at room temperature was investigated for 90 days...
October 2017: Veterinary Journal
https://www.readbyqxmd.com/read/29153038/a-divergent-pseudoglandular-configuration-of-cutaneous-plasmacytoma-in-dogs
#19
Brittany McHale, Uriel Blas-Machado, Fabiano N Oliveira, Daniel R Rissi
Cutaneous and mucocutaneous plasmacytoma (PCT) is a common neoplasm of dogs. Tumors can be single or multiple and occur predominantly in the oral cavity, lip, ears, digits, and trunk. Although these tumors typically offer no diagnostic challenge for the pathologist, subsets of PCTs with atypical morphologic configurations may make differentiation from other neoplasms difficult. We describe 6 cases of canine cutaneous and mucocutaneous PCT with pseudoglandular arrangement of neoplastic cells. The mean age of affected dogs was 11...
November 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29152844/faecal-microbiota-in-dogs-with-multicentric-lymphoma
#20
A Gavazza, G Rossi, G Lubas, M Cerquetella, Y Minamoto, J S Suchodolski
Malignant lymphoma B-cell type is the most common canine haematopoietic malignancy. Changes in intestinal microbiota have been implicated in few types of cancer in humans. The aim of this prospective and case-control study was to determine differences in faecal microbiota between healthy control dogs and dogs with multicentric lymphoma. Twelve dogs affected by multicentric, B-cell, stage III-IV lymphoma, and 21 healthy dogs were enrolled in the study. For each dog, faecal samples were analysed by Illumina sequencing of 16S rRNA genes and quantitative PCR (qPCR) for selected bacterial groups...
November 20, 2017: Veterinary and Comparative Oncology
keyword
keyword
5739
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"