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https://www.readbyqxmd.com/read/28545071/characterization-of-the-urinary-microbiome-in-healthy-dogs
#1
Erin N Burton, Leah A Cohn, Carol N Reinero, Hans Rindt, Stephen G Moore, Aaron C Ericsson
The urinary bladder in healthy dogs has dogmatically been considered free of bacteria. This study used culture independent techniques to characterize the healthy canine urinary microbiota. Urine samples collected by antepubic cystocentesis from dogs without urinary infection were used for DNA extraction. Genital tract and rectal samples were collected simultaneously from the same dogs. The V4 hypervariable region of the 16S rRNA bacterial gene was amplified and compared against Greengenes database for OTU assignment and relative abundance for urine, genital, and rectal samples...
2017: PloS One
https://www.readbyqxmd.com/read/28544974/cetuximab-modified-collagen-scaffold-directs-neurogenesis-of-injury-activated-endogenous-neural-stem-cells-for-acute-spinal-cord-injury-repair
#2
Xing Li, Yannan Zhao, Shixiang Cheng, Sufang Han, Muya Shu, Bing Chen, Xuyi Chen, Fengwu Tang, Nuo Wang, Yue Tu, Bin Wang, Zhifeng Xiao, Sai Zhang, Jianwu Dai
Studies have shown that endogenous neural stem cells (NSCs) activated by spinal cord injury (SCI) primarily generate astrocytes to form glial scar. The NSCs do not differentiate into neurons because of the adverse microenvironment. In this study, we defined the activation timeline of endogenous NSCs in rats with severe SCI. These injury-activated NSCs then migrated into the lesion site. Cetuximab, an EGFR signaling antagonist, significantly increased neurogenesis in the lesion site. Meanwhile, implanting cetuximab modified linear ordered collagen scaffolds (LOCS) into SCI lesion sites in dogs resulted in neuronal regeneration, including neuronal differentiation, maturation, myelination, and synapse formation...
May 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28544909/can-human-allergy-drug-fexofenadine-an-antagonist-of-histamine-h1-receptor-be-used-to-treat-dog-and-cat-homology-modeling-docking-and-molecular-dynamic-simulation-of-three-h1-receptors-in-complex-with-fexofenadine
#3
Safaa Sader, Jun Cai, Anna C G Muller, Chun Wu
Fexofenadine, a potent antagonist to human histamine 1 (H1) receptor, is a non-sedative third generation antihistamine that is widely used to treat various human allergic conditions such as allergic rhinitis, conjunctivitis and atopic dermatitis. Encouragingly, it's been successfully used to treat canine atopic dermatitis, this supports the notion that it might have a great potential for treating other canine allergic conditions and other mammal pets such as dog. Regrettably, while there is a myriad of studies conducted on the interactions of antihistamines with human H1 receptor, the similar studies on non-human pet H1 are considerably scarce...
May 17, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28544701/intradiscal-application-of-a-pcla-peg-pcla-hydrogel-loaded-with-celecoxib-for-the-treatment-of-back-pain-in-canines-what-s-in-it-for-humans
#4
Anna R Tellegen, Nicole Willems, Martijn Beukers, Guy C M Grinwis, Saskia G M Plomp, Clemens Bos, Maarten van Dijk, Mike de Leeuw, Laura B Creemers, Marianna A Tryfonidou, Björn P Meij
Chronic low back pain is a common clinical problem in both the human and canine population. Current pharmaceutical treatment often consists of oral anti-inflammatory drugs to alleviate pain. Novel treatments for degenerative disc diseases focus on local application of sustained released drug formulations. The aim of this study was to determine safety and feasibility of intradiscal application of a PCLA-PEG-PCLA hydrogel releasing celecoxib, a COX-2 inhibitor. Biocompatibility was evaluated after subcutaneous injection in mice and safety of intradiscal injection of the hydrogel was evaluated in experimental dogs with early spontaneous intervertebral disc (IVD) degeneration...
May 19, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28544629/household-pet-exposure-allergic-sensitization-and-rhinitis-in-the-u-s-population
#5
Josef Shargorodsky, Esther Garcia-Esquinas, Rachel Umanskiy, Ana Navas-Acien, Sandra Y Lin
BACKGROUND: The effect of animal dander exposure on allergic sensitization may be age-dependent. A comparison between the association of the levels of exposure to pet allergen with rhinitis symptoms and allergic sensitization in children and adults is yet to be performed in the U.S. POPULATION: HASH(0x53495f0) METHODS: Cross-sectional study of 3034 adults (age, 20 to 85 years) and 2104 children (age, 6 to 19 years) in the National Health and Nutrition Examination Survey, 2005-2006...
May 25, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28544337/growth-curves-of-normal-serum-total-ige-levels-throughout-childhood-a-quantile-analysis-in-a-birth-cohort
#6
Chiara Sacco, Serena Perna, Donatella Vicari, Marco Alfò, Carl-Peter Bauer, Ute Hoffman, Johannes Forster, Fred Zepp, Antje Schuster, Ulrich Wahn, Thomas Keil, Susanne Lau, Paolo Maria Matricardi
BACKGROUND: Previous studies of serum total IgE (t-IgE) were not able to discriminate well enough atopic from non-atopic subjects, i.e. with or without serum-specific IgE antibodies to allergens. OBJECTIVES: To model growth curves of the total IgE levels in children without atopic sensitization (hereafter defined as "normal" t-IgE levels) and to test their usefulness in predicting atopic sensitization. METHODS: The German Multicentre Allergy Study (MAS), a birth cohort with 1314 recruited newborns, began in 1990 and examined the participants until age 20y...
May 25, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28544307/afoxolaner-and-fluralaner-treatment-do-not-impact-on-cutaneous-demodex-populations-of-healthy-dogs
#7
Christine M Zewe, Laura Altet, Andrea T H Lam, Lluís Ferrer
BACKGROUND: Fluralaner and afoxolaner are isoxazolines licensed for the treatment of flea and tick infestations. Isoxazolines have also shown efficacy for treatment of demodicosis. Nothing is known about the impact of these compounds on the populations of Demodex in healthy dogs. HYPOTHESIS/OBJECTIVES: The objective of this study was to measure the prevalence of Demodex in the skin of healthy dogs prior to and following the use of either afoxolaner or fluralaner, using real-time PCR (RT-PCR) for Demodex DNA...
May 23, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28544277/use-of-a-vascular-closure-device-during-percutaneous-arterial-access-in-a-dog-with-impaired-hemostasis
#8
Brian A Scansen, Caitlin M Hokanson, Steven G Friedenberg, Hooman Khabiri
OBJECTIVE: To report the use of a vascular closure device (VCD) to provide rapid arterial hemostasis following percutaneous femoral arterial catheterization and diagnostic angiography in a thrombocytopenic and coagulopathic dog. CASE SUMMARY: A 6-year-old female spayed Kai Ken Tora dog presented after vehicular trauma. The dog was diagnosed with traumatic pneumothorax, degloving wounds of the right antebrachium, subcutaneous hemorrhage within the axillary tissues of the left thoracic limb, and anemia and thrombocytopenia secondary to acute hemorrhage...
May 23, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28544250/prevalence-of-and-risk-factors-for-intraoperative-gastroesophageal-reflux-and-postanesthetic-vomiting-and-diarrhea-in-dogs-undergoing-general-anesthesia
#9
Carlos Torrente, Isabel Vigueras, Edgar G Manzanilla, Cecilia Villaverde, Laura Fresno, Bibiana Carvajal, Marina Fiñana, Cristina Costa-Farré
OBJECTIVE: To determine the prevalence of intraoperative gastroesophageal reflux (GER) and postanesthetic vomiting and diarrhea, and to evaluate risk factors associated with these gastrointestinal disorders (GID) in dogs undergoing general anesthesia. DESIGN: Prospective observational study. SETTING: University teaching hospital. ANIMALS: Two hundred thirty-seven client-owned dogs undergoing general inhalant anesthesia for diagnostic or surgical purposes...
May 23, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28544149/what-s-in-a-name-the-incorrect-use-of-case-series-as-a-study-design-label-in-studies-involving-dogs-and-cats
#10
J M Sargeant, A M O'Connor, J N Cullen, K M Makielski, A Jones-Bitton
BACKGROUND: Study design labels are used to identify relevant literature to address specific clinical and research questions and to aid in evaluating the evidentiary value of research. Evidence from the human healthcare literature indicates that the label "case series" may be used inconsistently and inappropriately. OBJECTIVE: Our primary objective was to determine the proportion of studies in the canine and feline veterinary literature labeled as case series that actually corresponded to descriptive cohort studies, population-based cohort studies, or other study designs...
May 24, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28544017/evaluation-of-canine-adverse-food-reactions-by-patch-testing-with-single-proteins-single-carbohydrates-and-commercial-foods
#11
Cornelia Johansen, Claire Mariani, Ralf S Mueller
BACKGROUND: Adverse food reaction (AFR) is an important differential diagnosis for the pruritic dog. It is usually diagnosed by feeding an elimination diet with a novel protein and carbohydrate source for eight weeks followed by subsequent food provocation. A previous study demonstrated that patch testing dogs with foods had a high sensitivity and negative predictability for selection of elimination diet ingredients. HYPOTHESIS/OBJECTIVES: The aim of this study was to investigate patch testing with proteins, carbohydrates and dry commercial dog food in dogs to determine whether there was value in patch testing to aid the diagnosis of canine adverse food reaction...
May 22, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28543991/sensitivity-and-specificity-of-plasma-alt-alp-and-bile-acids-for-hepatitis-in-labrador-retrievers
#12
K Dirksen, I A Burgener, J Rothuizen, T S G A M van den Ingh, L C Penning, B Spee, H Fieten
BACKGROUND: Biochemical indicators for diagnosing liver disease are plasma alanine aminotransferase activity (ALT), alkaline phosphatase activity (ALP), and bile acid concentration (BA). OBJECTIVES: To determine the sensitivity and specificity of ALT, ALP, and BA for detecting primary hepatitis (PH) in clinically healthy Labrador retrievers and investigate whether ALT and ALP can discriminate between dogs with PH and nonspecific reactive hepatitis (RH). ANIMALS: 191 clinically healthy and 51 clinically ill Labrador retrievers with hepatic histopathology...
May 23, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28543945/indirect-computed-tomography-lymphangiography-with-aqueous-contrast-for-evaluation-of-sentinel-lymph-nodes-in-dogs-with-tumors-of-the-head
#13
Janet A Grimes, Scott A Secrest, Nicole C Northrup, Corey F Saba, Chad W Schmiedt
Sentinel lymph node evaluation is widely used in human medicine to evaluate the first lymph node(s) to which a tumor drains. Sentinel lymph node biopsy allows avoidance of extensive lymphadenectomies in cases where the sentinel lymph node is negative for metastasis, thereby reducing patient morbidity. It has been shown that regional lymph nodes are not always the sentinel lymph node, thus identification and sampling of sentinel lymph nodes allows for more accurate staging, which is critical for treatment and prognostication in dogs with cancer...
May 21, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28543810/in-vitro-bactericidal-activity-of-blue-light-465-nm-phototherapy-on-meticillin-susceptible-and-meticillin-resistant-staphylococcus-pseudintermedius
#14
Amy H Schnedeker, Lynette K Cole, Gwendolen Lorch, Sandra F Diaz, John Bonagura, Joshua B Daniels
BACKGROUND: Staphylococcus pseudintermedius is the most common cause of bacterial skin infections in dogs. Meticillin-resistant infections have become more common and are challenging to treat. Blue light phototherapy may be an option for treating these infections. HYPOTHESIS/OBJECTIVES: The objective of this study was to measure the in vitro bactericidal activity of 465 nm blue light on meticillin-susceptible Staphylococcus pseudintermedius (MSSP) and meticillin-resistant Staphylococcus pseudintermedius (MRSP)...
May 22, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28543806/effect-of-microthreads-on-coronal-bone-healing-of-narrow-diameter-implants-with-reverse-tapered-design-in-beagle-dogs
#15
Yun-Young Chang, Su-Hwan Kim, Keun-Oh Park, Jeong-Ho Yun
OBJECTIVES: The objective of this study was to investigate the effect of microthreads on the coronal bone healing of narrow-diameter implants with reverse-tapered design. MATERIAL AND METHODS: A total of 52 implants were classified into two groups according to presence or absence of coronal microthreads, the reverse-tapered narrow-diameter implant (RTN) group, and the reverse-tapered narrow-diameter implant with microthreads (RTNM) group. The implants were installed in split-mouth design in the edentulous mandible of six dogs...
May 22, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28543780/intranasal-midazolam-versus-rectal-diazepam-for-the-management-of-canine-status-epilepticus-a-multicenter-randomized-parallel-group-clinical-trial
#16
M Charalambous, S F M Bhatti, L Van Ham, S Platt, N D Jeffery, A Tipold, J Siedenburg, H A Volk, D Hasegawa, A Gallucci, G Gandini, M Musteata, E Ives, A E Vanhaesebrouck
BACKGROUND: Intranasal administration of benzodiazepines has shown superiority over rectal administration for terminating emergency epileptic seizures in human trials. No such clinical trials have been performed in dogs. OBJECTIVE: To evaluate the clinical efficacy of intranasal midazolam (IN-MDZ), via a mucosal atomization device, as a first-line management option for canine status epilepticus and compare it to rectal administration of diazepam (R-DZP) for controlling status epilepticus before intravenous access is available...
May 24, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28543518/green-discolouration-of-urine-following-propofol-infusion-in-a-dog
#17
D Flaherty, A Auckburally
A three-year-old, female neutered Weimaraner was presented with a history of neck pain and tetraparesis. MRI revealed an extradural mass at the level of C3 vertebra, which was thought to be a spinal abscess, and the dog was scheduled for surgical exploration the following morning. Overnight the dog developed an exaggerated ventilatory pattern, with paradoxical inward movement of the thorax on inspiration. Arterial blood gas analysis revealed respiratory acidosis and ventilator support was initiated to prevent excessive respiratory fatigue...
May 25, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28543363/histiocytic-sarcoma-in-14-miniature-schnauzers-a-new-breed-predisposition
#18
J A Lenz, E Furrow, L E Craig, C M Cannon
OBJECTIVES: To describe a series of miniature schnauzers diagnosed with histiocytic sarcoma and assess for possible breed predisposition. MATERIALS AND METHODS: Medical records of miniature schnauzers with a diagnosis of histiocytic sarcoma between January 2008 and April 2015 were reviewed. Data collected included signalment, body weight, presenting complaint, date of diagnosis, clinicopathologic and diagnostic imaging findings, treatment, therapeutic response, date of death or last follow-up and necropsy findings...
May 25, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28543304/biomechanical-comparison-between-pins-and-polymethylmethacrylate-and-the-sop-locking-plate-system-to-stabilize-canine-lumbosacral-fracture-luxation-in-flexion-and-extension
#19
Johannes J Nel, Cor-Jacques Kat, Gert L Coetzee, Paul J van Staden
OBJECTIVE: To determine the stability of a simulated complete L7-S1 fracture-luxation immobilized with SOP locking plate system, compared to pins and polymethylmethacrylate (PMMA). STUDY DESIGN: In vitro biomechanical study. ANIMALS: Cadaver specimens of 18 skeletally mature large-breed dogs. MATERIALS AND METHODS: Specimens were randomly stabilized with one of the two fixation techniques. Lumbosacral spine specimens (L5-S3) were subjected to a bending moment applied to the caudal and cranial ends of the specimen...
May 24, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28543264/implication-clinical-and-biological-impact-of-vector-borne-haemopathogens-in-anaemic-dogs-in-france-a-prospective-study
#20
T Bouzouraa, J L Cadore, J Chene, I Goy-Thollot, F Ponce, K Chalvet-Monfray, B Rannou, L Chabanne
OBJECTIVES: To prospectively describe the clinical and biological impact of vector-borne haemopathogens in anaemic dogs in France and occurrence of haemolysis. MATERIALS AND METHODS: This prospective descriptive cohort study includes 134 client-owned dogs that were anaemic on admission at the Veterinary Teaching Hospital of VetAgro Sup, Lyon, France. They underwent comprehensive screening with PCR to detect a panel of vector-borne haemopathogens, SNAP Leishmania and SNAP 4Dx Plus (IDEXX)...
May 23, 2017: Journal of Small Animal Practice
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