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https://www.readbyqxmd.com/read/29771101/-evidence-of-lack-of-concordance-between-hemodialysis-patients-and-nurses-on-the-presence-and-severity-of-symptoms
#1
Christine Cohen, Matteo Antonini, Philippe Delmas
Hemodialysis patients represent a fragile population experiencing many symptoms (e.g., pain, fatigue) that impact their quality of life. The presence and severity of these symptoms are significantly underestimated by health professionals. The purpose of this study is to describe and compare the symptoms perceived by hemodialysis patients versus those detected by nurses and to discuss the possible causes of the disparity observed. A total of 123 patients and 70 nurses working in six hemodialysis centers were included in this study...
March 2018: Recherche en Soins Infirmiers
https://www.readbyqxmd.com/read/29761158/phase-ii-study-of-ruxolitinib-a-selective-jak1-2-inhibitor-in-patients-with-metastatic-triple-negative-breast-cancer
#2
Daniel G Stover, Carlos R Gil Del Alcazar, Jane Brock, Hao Guo, Beth Overmoyer, Justin Balko, Qiong Xu, Aditya Bardia, Sara M Tolaney, Rebecca Gelman, Maxwell Lloyd, Yu Wang, Yaomin Xu, Franziska Michor, Vivian Wang, Eric P Winer, Kornelia Polyak, Nancy U Lin
Preclinical data support a role for the IL-6/JAK2/STAT3 signaling pathway in breast cancer. Ruxolitinib is an orally bioavailable receptor tyrosine inhibitor targeting JAK1 and JAK2. We evaluated the safety and efficacy of ruxolitinib in patients with metastatic breast cancer. This was a non-randomized phase II study enrolling patients with refractory, metastatic triple-negative breast cancer. The primary endpoint was objective response by RECIST 1.1. The study was designed to enroll patients whose archival tumor tissue was pSTAT3-positive ( T -score >5) by central immunohistochemistry...
2018: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29758055/active-recovery-affects-the-recovery-of-the-corticospinal-system-but-not-of-muscle-contractile-properties
#3
Louis-Solal Giboin, Ehsan Amiri, Raphael Bertschinger, Markus Gruber
PURPOSE: Active recovery is often used by athletes after strenuous exercise or competition but its underlying mechanisms are not well understood. We hypothesized that active recovery speeds-up recovery processes within the muscle and the central nervous system (CNS). METHODS: We assessed muscular and CNS recovery by measuring the voluntary activation (VA) in the vastus lateralis muscle with transcranial magnetic stimulation (VATMS) and peripheral nerve stimulation (VAPNS) during maximal voluntary contractions (MVC) of the knee extensors in 11 subjects...
2018: PloS One
https://www.readbyqxmd.com/read/29755590/wide-pulse-high-frequency-low-intensity-neuromuscular-electrical-stimulation-has-potential-for-targeted-strengthening-of-an-intrinsic-foot-muscle-a-feasibility-study
#4
Darren C James, Matthew C Solan, Katya N Mileva
Background: Strengthening the intrinsic foot muscles is a poorly understood and largely overlooked area. In this study, we explore the feasibility of strengthening m . abductor hallucis (AH) with a specific paradigm of neuromuscular electrical stimulation; one which is low-intensity in nature and designed to interleave physiologically-relevant low frequency stimulation with high-frequencies to enhance effective current delivery to spinal motoneurones, and enable a proportion of force produced by the target muscle to be generated from a central origin...
2018: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/29754195/three-different-motor-task-strategies-to-assess-neuromuscular-adjustments-during-fatiguing-muscle-contractions-in-young-and-older-men
#5
Laura Kyguoliene, Albertas Skurvydas, Nerijus Eimantas, Neringa Baranauskiene, Rasa Steponaviciute, Laura Daniuseviciute, Henrikas Paulauskas, Margarita Cernych, Marius Brazaitis
Healthy aging is associated with a marked decline in motor performance. The functional consequences of applying varying novel or unexpected motor stimuli during intermittent isometric prolonged (fatiguing) motor tasks for lower limb neuromuscular fatigability and steadiness, perception of effort, and blood markers of stress in healthy aged men compared with young men have not been investigated. The participants in this study were 15 young men (aged 22 ± 4 years) and 10 older men (aged 67 ± 6 years)...
May 12, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29751049/increased-butyrate-priming-in-the-gut-stalls-microbiome-associated-gastrointestinal-inflammation-and-hepatic-metabolic-reprogramming-in-a-mouse-model-of-gulf-war-illness
#6
Ratanesh Kumar Seth, Diana Kimono, Firas Alhasson, Sutapa Sarkar, Muayad Albadrani, Stephen K Lasley, Ronnie Horner, Patricia Janulecewicz, Mitzi Nagarkatti, Prakash Nagarkatti, Kimberly Sullivan, Saurabh Chatterjee
Most of the associated pathologies in Gulf War Illness (GWI) have been ascribed to chemical and pharmaceutical exposures during the war. Since an increased number of veterans complain of gastrointestinal (GI), neuroinflammatory and metabolic complications as they age and there are limited options for a cure, the present study was focused to assess the role of butyrate, a short chain fatty acid for attenuating GWI-associated GI and metabolic complications. Results in a GWI-mouse model of permethrin and pyridostigmine bromide (PB) exposure showed that oral butyrate restored gut homeostasis and increased GPR109A receptor copies in the small intestine (SI)...
May 8, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29750396/a-phase-1-2-dose-finding-safety-and-activity-study-of-cabazitaxel-in-pediatric-patients-with-refractory-solid-tumors-including-tumors-of-the-central-nervous-system
#7
Peter E Manley, Tanya Trippett, Amy A Smith, Margaret E Macy, Sarah E S Leary, Jessica Boklan, Kenneth J Cohen, Stewart Goldman, Lindsay B Kilburn, Girish Dhall, Jeanne Devin, Cynthia E Herzog, Sonia Partap, Floris Fauchet, Emmy Badreddine, John P Bernard, Susan N Chi
BACKGROUND: This phase 1/2 study (NCT01751308) evaluated cabazitaxel in pediatric patients. Phase 1 determined the maximum tolerated dose (MTD) in patients with recurrent/refractory solid tumors, including central nervous system (CNS) tumors. Phase 2 evaluated activity in pediatric recurrent high-grade glioma (HGG) or diffuse intrinsic pontine glioma (DIPG). PROCEDURE: In phase 1, a 3 + 3 dose-escalation study design was followed. Cabazitaxel was administered at a starting dose of 20 mg/m2 ...
May 11, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29750060/fascial-preadipocytes-another-missing-piece-of-the-puzzle-to-understand-fibromyalgia
#8
Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Francesca Cavallaro, David Lintonbon
Fibromyalgia (FM) syndrome is a chronic condition causing pain, affecting approximately 0.5%-6% of the developed countries' population, and on average, 2% of the worldwide population. Despite the large amount of scientific literature available, the FM etiology is still uncertain. The diagnosis is based on the clinical presentation and the severity of the symptomatology. Several studies pointed out pathological alterations within the central nervous system, suggesting that FM could originate from a central sensitization of the pain processing centers...
2018: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29745520/-research-on-classification-of-brain-functional-network-features-during-mental-fatigue
#9
Shuo Yang, Na Ai, Lei Wang, Ying Zhang, Guizhi Xu
This study is aimed to investigate objective indicators of mental fatigue evaluation to improve the accuracy of mental fatigue evaluation. Mental fatigue was induced by a sustained cognitive task. The brain functional networks in two states (normal state and mental fatigue state) were constructed based on electroencephalogram (EEG) data. This study used complex network theory to calculate and analyze nodal characteristics parameters (degree, betweenness centrality, clustering coefficient and average path length of node), and served them as the classification features of support vector machine (SVM)...
April 1, 2018: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29738677/greater-fatigability-in-knee-flexors-vs-knee-extensors-after-a-standardized-fatiguing-protocol
#10
Giuseppe Coratella, Sidney Grosprêtre, Philippe Gimenez, Laurent Mourot
The present study aimed to investigate the effects of a standardized fatiguing protocol on central and peripheral fatigue in knee-flexors and knee-extensors. Thirteen healthy men (age: 23 ± 3 years; height: 1.78 ± 0.09 m; body-mass: 73.6 ± 9.2 kg) volunteered for the present study. Maximal voluntary contraction (MVC), Electromyography (EMG) activity, voluntary activation level (VAL) as an index of central fatigue and twitch potentiation as an index of peripheral fatigue were measured before and after the fatiguing protocol...
May 8, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29730417/myelin-injury-in-the-central-nervous-system-and-alzheimer-s-disease
#11
REVIEW
Sha-Sha Wang, Zhao Zhang, Tian-Bi Zhu, Shi-Feng Chu, Wen-Bin He, Nai-Hong Chen
Myelin is a membrane wrapped around the axon of the nerve cell, which is composed of the mature oligodendrocytes. The role of myelin is to insulate and prevent the nerve electrical impulses from the axon of the neurons to the axons of the other neurons, which is essential for the proper functioning of the nervous system. Minor changes in myelin thickness could lead to substantial changes in conduction speed and may thus alter neural circuit function. Demyelination is the myelin damage, which characterized by the loss of nerve sheath and the relative fatigue of the neuronal sheath and axon...
May 3, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29726743/opinion-paper-the-role-of-work-in-the-management-of-medically-unexplained-physical-symptoms
#12
Els Tobback, An Mariman, Lies Clauwaert, Lode Godderis, Stefan Heytens, Patrick Ruppol, Daniel Spooren, Rita Tytgat, Martine De Muynck, Dirk Vogelaers
OBJECTIVES: Patients with medically unexplained physical symptoms suffer from chronic fatigue and/or pain in combination with a variety of other symptoms. A flexible, biopsychosocial approach is needed for diagnostic screening and global management. It is crucial to involve the direct patient environment, including family, friends, colleagues as well as health providers, evaluation, and reintegration sector. The aim of this paper is to review the importance of work in the management of medically unexplained physical symptoms...
May 4, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29726694/the-role-of-the-nervous-system-in-neuromuscular-fatigue-induced-by-ultra-endurance-exercise
#13
Guillaume Y Millet, Vincent Martin, John Temesi
Ultra-endurance events are not a recent development but they have only become very popular in the last two decades, particularly ultra-marathons run on trails. The present paper reviews the role of the central nervous system (CNS) in neuromuscular fatigue induced by ultra-endurance exercise. Large decreases in voluntary activation are systematically found in ultra-endurance running but are attenuated in ultra-endurance cycling for comparable intensity and duration. This indirectly suggests that afferent feedback, rather than neurobiological changes within the CNS, is determinant in the amount of central fatigue produced...
May 4, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29725306/muscle-performance-investigated-with-a-novel-smart-compression-garment-based-on-pressure-sensor-force-myography-and-its-validation-against-emg
#14
Aaron Belbasis, Franz Konstantin Fuss
Muscle activity and fatigue performance parameters were obtained and compared between both a smart compression garment and the gold-standard, a surface electromyography (EMG) system during high-speed cycling in seven participants. The smart compression garment, based on force myography (FMG), comprised of integrated pressure sensors that were sandwiched between skin and garment, located on five thigh muscles. The muscle activity was assessed by means of crank cycle diagrams (polar plots) that displayed the muscle activity relative to the crank cycle...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29719440/pharmacologic-interventions-for-fatigue-in-cancer-and-transplantation-a-meta-analysis
#15
REVIEW
D Tomlinson, P D Robinson, S Oberoi, D Cataudella, N Culos-Reed, H Davis, N Duong, F Gibson, M Götte, P Hinds, S L Nijhof, P van der Torre, S Cabral, L L Dupuis, L Sung
Background: Our objective was to determine whether, compared with control interventions, pharmacologic interventions reduce the severity of fatigue in patients with cancer or recipients of hematopoietic stem-cell transplantation (hsct). Methods: For a systematic review, we searched medline, embase, the Cochrane Central Register of Controlled Trials, cinahl, and Psychinfo for randomized trials of systemic pharmacologic interventions for the management of fatigue in patients with cancer or recipients of hsct...
April 2018: Current Oncology
https://www.readbyqxmd.com/read/29719113/a-phase-1-study-of-eribulin-mesylate-e7389-a-novel-microtubule-targeting-chemotherapeutic-agent-in-children-with-refractory-or-recurrent-solid-tumors-a-children-s-oncology-group-phase-1-consortium-study-advl1314
#16
Eric S Schafer, Rachel E Rau, Stacey Berg, Xiaowei Liu, Charles G Minard, David D'Adamo, Rachael Scott, Larisa Reyderman, Gresel Martinez, Sandhya Devarajan, Joel M Reid, Elizabeth Fox, Brenda J Weigel, Susan M Blaney
BACKGROUND: Eribulin mesylate is a novel anticancer agent that inhibits microtubule growth, without effects on shortening, and promotes nonproductive tubulin aggregate formation. We performed a phase 1 trial to determine the dose-limiting toxicities (DLTs), maximum tolerated or recommended phase 2 dose (MTD/RP2D), and pharmacokinetics (PK) of eribulin in children with refractory or recurrent solid (excluding central nervous system) tumors. METHODS: Eribulin was administered intravenously on days 1 and 8 in 21-day cycles...
May 2, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29719079/effects-of-ipsilateral-and-contralateral-fatigue-and-muscle-blood-flow-occlusion-on-the-complexity-of-knee-extensor-torque-output-in-humans
#17
Jamie Pethick, Samantha L Winter, Mark Burnley
NEW FINDINGS: In this study we show that the fatigue-induced loss of isometric torque complexity does not recover if the fatigued muscle's blood flow is occluded during recovery, suggesting a pivotal role for peripheral mechanisms in this effect. When the contralateral limb is fatigued, the complexity of isometric torque output is unaffected even if the contralateral limb's blood flow is occluded, which suggests neither central fatigue nor afferent feedback from ischaemic muscle influence the complexity of torque output in an otherwise fresh muscle...
May 2, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29718968/acute-attenuation-of-fatigue-after-sodium-bicarbonate-supplementation-does-not-manifest-into-greater-training-adaptations-after-10-weeks-of-resistance-training-exercise
#18
Jason C Siegler, Paul W M Marshall, Harrison Finn, Rebecca Cross, Kurt Mudie
PURPOSE: In two concurrent studies, we aimed to a) confirm the acute effect of 0.3 g·kg-1 body weight (BW) sodium bicarbonate (NaHCO3) supplementation on central and peripheral mechanisms associated with explosive power (Study 1) and b) determine whether chronic NaHCO3 supplementation would improve the adaptive response of the neuromuscular system during a 10-week resistance training program (Study 2). METHODS: Eight resistance trained participants volunteered after providing written consent...
2018: PloS One
https://www.readbyqxmd.com/read/29709423/basic-and-clinical-aspects-of-antimuscarinic-agents-used-to-treat-overactive-bladder
#19
REVIEW
Shizuo Yamada, Yoshihiko Ito, Saori Nishijima, Katsumi Kadekawa, Kimio Sugaya
Antimuscarinic agents are now widely used as the pharmacological therapy for overactive bladder (OAB) because neuronal (parasympathetic nerve) and non-neuronal acetylcholine play a significant role for the bladder function. In this review, we will highlight basic and clinical aspects of eight antimuscarinic agents (oxybutynin, propiverine, tolterodine, solifenacin, darifenacin, trospium, imidafenacin, and fesoterodine) clinically used to treat urinary dysfunction in patients with OAB. The basic pharmacological characteristics of these eight antimuscarinic agents include muscarinic receptor subtype selectivity, functional bladder selectivity, and muscarinic receptor binding in the bladder and other tissues...
April 27, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29707422/modafinil-for-the-improvement-of-patient-outcomes-following-traumatic-brain-injury
#20
REVIEW
Amne Borghol, Michael Aucoin, Ifeanyichukwu Onor, Dana Jamero, Fadi Hawawini
Objective : The authors sought to assess the literature evidence on the efficacy of modafinil use in patients with fatigue or excessive daytime sleepiness (EDS) secondary to traumatic brain injury (TBI). Method of Research : A literature search of Medline and PubMed was performed using the EBSCOhost database. Primary literature, observational studies, meta-analyses, case reports, and systematic reviews were assessed for content regarding modafinil and psychostimulant use in patients with TBI. Of the 23 articles collected, three randomized, controlled studies, three observational studies, one case report, and two systematic reviews gave a description of modafinil use in TBI patients...
April 1, 2018: Innovations in Clinical Neuroscience
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