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https://www.readbyqxmd.com/read/28211818/comparison-of-the-effects-of-bilateral-and-unilateral-training-after-stroke-a-meta-analysis
#1
Yejin Lee, Moon Young Kim, Ji-Hyuk Park, Hae Yean Park
BACKGROUND: The differential effects of bilateral and unilateral training on upper extremity (UE) function remain unclear. OBJECTIVE: To compare the effectiveness of bilateral and unilateral training on UE function and activities of daily living (ADL) after stroke. METHODS: Randomized controlled trials (RCTs) were selected for inclusion by two reviewers after searching the following databases: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), and KoreaMed...
February 15, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28207951/endurance-capacity-and-neuromuscular-fatigue-following-high-vs-moderate-intensity-endurance-training-a-randomised-trial
#2
Thomas J O'Leary, Johnny Collett, Ken Howells, Martyn G Morris
High-intensity exercise induces significant central and peripheral fatigue, however the effect of endurance training on these mechanisms of fatigue is poorly understood. We compared the effect of cycling endurance training of disparate intensities on high-intensity exercise endurance capacity and the associated limiting central and peripheral fatigue mechanisms. Twenty adults were randomly assigned to 6 weeks of either high-intensity interval training (HIIT, 6-8 × 5 min at halfway between lactate threshold and maximal oxygen uptake [50%Δ]) or volume matched moderate-intensity continuous training (CONT, ~60-80 min at 90% lactate threshold)...
February 16, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28204862/effect-of-constant-predictable-and-unpredictable-motor-tasks-on-motor-performance-and-blood-markers-of-stress
#3
Laura Kyguoliene, Albertas Skurvydas, Nerijus Eimantas, Neringa Baranauskienė, Dalia Mickeviciene, Daiva Urboniene, Margarita Cernych, Marius Brazaitis
An unfamiliar or novel physical stimulus induces activation of dopaminergic neurons within the brain and greater activity in areas involved in emotion; considering this, we aimed to establish whether unpredictable prolonged (fatiguing) motor task (vs. constant vs. predictable) evokes greater dopaminergic activity, enhances neuromuscular performance, motor accuracy, and perception of effort, and delays overall central fatigue. Fifteen healthy male volunteers (aged 22 ± 4 years) were required to perform 1 of 3 exercise trials (at least 1 week apart) of 100 intermittent isometric contraction (IIC) tasks involving knee extensions at 60° flexion...
February 16, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28198465/fatigue-related-impairments-in-oculomotor-control-are-prevented-by-norepinephrine-dopamine-reuptake-inhibition
#4
Charlotte J W Connell, Benjamin Thompson, Jason Turuwhenua, Alexa Srzich, Nicholas Gant
Fatigue-induced reductions in saccade velocity have been reported following acute, prolonged exercise. Interestingly, the detrimental impact of fatigue on oculomotor control can be prevented by a moderate dose of caffeine. This effect may be related to central catecholamine upregulation via caffeine's action as an adenosine antagonist. To test this hypothesis, we compared the protective effect of caffeine on oculomotor control post-exercise to that of a norepinephrine-dopamine reuptake inhibitor. Within a placebo-controlled crossover design, 12 cyclists consumed placebo, caffeine or a norepinephrine-dopamine reuptake inhibitor (bupropion) during 180 minutes of stationary cycling...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28197103/increases-in-brain-1-h-mr-glutamine-and-glutamate-signals-following-acute-exhaustive-endurance-exercise-in-the-rat
#5
Maciej Świątkiewicz, Michał Fiedorowicz, Jarosław Orzeł, Marlena Wełniak-Kamińska, Piotr Bogorodzki, Józef Langfort, Paweł Grieb
Objective: Proton magnetic resonance spectroscopy ((1)H-MRS) in ultra-high magnetic field can be used for non-invasive quantitative assessment of brain glutamate (Glu) and glutamine (Gln) in vivo. Glu, the main excitatory neurotransmitter in the central nervous system, is efficiently recycled between synapses and presynaptic terminals through Glu-Gln cycle which involves glutamine synthase confined to astrocytes, and uses 60-80% of energy in the resting human and rat brain. During voluntary or involuntary exercise many brain areas are significantly activated, which certainly intensifies Glu-Gln cycle...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28196165/effect-of-cervical-collar-removal-on-the-fracture-load-of-anterior-zirconia-crowns
#6
Fernanda Campos, Mayra Cardoso, Renata Marques de Melo, Marco Antonio Bottino, Rodrigo Oa Souza
The objective of this study was to assess the influence of the extension of collar and fatigue cycling on the fracture load of anterior zirconia crowns. A total of 60 anterior full-crown preparations (central incisor) were machined in glass fiber-filled epoxy resin. Zirconia copings were designed and milled using computer-aided design/computer-assisted manufacture (thickness: buccal = 0.62 mm, lingual = 0.65 mm, incisal = 0.72 mm). The cervical collars (occlusogingival height = 0.8 mm, buccolingual width = 1...
March 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28194755/withdrawn-exercise-for-dysmenorrhoea
#7
REVIEW
Julie Brown, Stephen Brown
BACKGROUND: Dysmenorrhoea is characterised by cramping lower abdominal pain that may radiate to the lower back and upper thighs and is commonly associated with nausea, headache, fatigue and diarrhoea. Physical exercise has been suggested as a non-medical approach to the management of these symptoms. OBJECTIVES: To assess the evidence for the effectiveness of exercise in the treatment of dysmenorrhoea. SEARCH METHODS: A search was conducted using the methodology of the Menstrual Disorders and Subfertility Group (August 2009)...
February 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28188814/how-people-with-multiple-sclerosis-cope-with-a-sustained-finger-motor-task-a-behavioural-and-fmri-study
#8
Laura Bonzano, Matteo Pardini, Luca Roccatagliata, Giovanni L Mancardi, Marco Bove
Motor and non-motor basal ganglia (BG) circuits can help healthy subjects cope with task-induced central fatigue and re-establish motor performance after deterioration. This work aimed to assess whether patients with multiple sclerosis (MS) were able to recover motor performance after deterioration due to a demanding task and whether BG activity played a role in performance recovery in this population. Fourteen patients with MS performed a finger-tapping sequence with their right hand during three fMRI sessions: at baseline, after a demanding finger motor task (5-min sequence repetition) and after a short rest period...
February 7, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28182134/differential-pharmacology-and-clinical-utility-of-sonidegib-in-advanced-basal-cell-carcinoma
#9
REVIEW
Mohd Wahid, Arshad Jawed, Sajad Ahmad Dar, Raju K Mandal, Shafiul Haque
Patients suffering from advanced basal cell carcinoma (BCC) have very limited treatment options. Sonidegib selectively inhibits the growth of Hedgehog pathway-dependent tumors and can treat locally advanced BCC patients who are not candidates for surgery or radiation therapy. The BOLT clinical trials were conducted to evaluate the efficacy/potency of sonidegib in the treatment of advanced BCC or metastatic BCC. The patients were randomized in 1:2 ratios to receive 200 or 800 mg oral sonidegib daily, stratified by disease, histological subtype and geographical region...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28170449/a-systematic-review-of-surface-electromyography-analyses-of-the-bench-press-movement-task
#10
Petr Stastny, Artur Gołaś, Dusan Blazek, Adam Maszczyk, Michał Wilk, Przemysław Pietraszewski, Miroslav Petr, Petr Uhlir, Adam Zając
BACKGROUND: The bench press exercise (BP) plays an important role in recreational and professional training, in which muscle activity is an important multifactorial phenomenon. The objective of this paper is to systematically review electromyography (EMG) studies performed on the barbell BP exercise to answer the following research questions: Which muscles show the greatest activity during the flat BP? Which changes in muscle activity are related to specific conditions under which the BP movement is performed? STRATEGY: PubMed, Scopus, Web of Science and Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library were searched through June 10, 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28166877/effects-of-display-curvature-display-zone-and-task-duration-on-legibility-and-visual-fatigue-during-visual-search-task
#11
Sungryul Park, Donghee Choi, Jihhyeon Yi, Songil Lee, Ja Eun Lee, Byeonghwa Choi, Seungbae Lee, Gyouhyung Kyung
This study examined the effects of display curvature (400, 600, 1200 mm, and flat), display zone (5 zones), and task duration (15 and 30 min) on legibility and visual fatigue. Each participant completed two 15-min visual search task sets at each curvature setting. The 600-mm and 1200-mm settings yielded better results than the flat setting in terms of legibility and perceived visual fatigue. Relative to the corresponding centre zone, the outermost zones of the 1200-mm and flat settings showed a decrease of 8%-37% in legibility, whereas those of the flat setting showed an increase of 26%-45% in perceived visual fatigue...
April 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28163706/role-of-inflammation-in-human-fatigue-relevance-of-multidimensional-assessments-and-potential-neuronal-mechanisms
#12
REVIEW
Bianka Karshikoff, Tina Sundelin, Julie Lasselin
Fatigue is a highly disabling symptom in various medical conditions. While inflammation has been suggested as a potential contributor to the development of fatigue, underlying mechanisms remain poorly understood. In this review, we propose that a better assessment of central fatigue, taking into account its multidimensional features, could help elucidate the role and mechanisms of inflammation in fatigue development. A description of the features of central fatigue is provided, and the current evidence describing the association between inflammation and fatigue in various medical conditions is reviewed...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28158150/electric-stimulation-for-pain-relief-in-patients-with-fibromyalgia-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#13
Ana Paula de Silva Salazar, Cinara Stein, Ritchele Redivo Marchese, Rodrigo Della Mea Plentz, Aline De Souza Pagnussat
BACKGROUND: Fibromyalgia (FM) is a syndrome whose primary symptoms include chronic widespread muscle pain and fatigue. The treatment of patients with FM aims to provide symptomatic relief and improvement in physical capacities to perform daily tasks and quality of life. Invasive or non-invasive electric stimulation (ES) is used for pain relief in patients with FM. OBJECTIVE: This systematic review aimed to assess the effects of treatment with ES, combined or not combined with other types of therapy, for pain relief in patients with FM...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28156532/experience-of-patient-death-and-subsequent-bereavement-by-members-of-the-oncology-team-in-the-outpatient-setting
#14
(no author information available yet)
: 244 Background: Working with cancer patients is considered inherently stressful with high levels of burnout reported. There is limited research that focuses on the multidisciplinary team as a whole; research to date tends to focus on patient death from the perspective of the bedside oncology nurse, the physician or social worker. With the focus on those disciplines individually, thereby ignoring the centrality of the multidisciplinary nature of oncology care and excluding fundamental team members who provide care and are potentially impacted by the death of the patient...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28140689/the-efficacy-of-trabectedin-in-treating-ovarian-cancer
#15
Eleonora Teplinsky, Thomas J Herzog
The majority of women with epithelial ovarian cancer present with advanced stage disease and there is a critical need for novel drugs and treatment strategies to improve outcomes. Trabectedin is a unique cytotoxic agent with a complex mechanism of action. It binds to guanines in the N2 position in the minor groove of DNA and its cytotoxicity involves DNA repair pathways and transcription regulation. Trabectedin's activity is also related to the drug-induced changes of the tumor microenvironment. It has been shown to improve progression-free survival in combination with pegylated liposomal doxorubicin in patients with platinum-sensitive relapsed ovarian cancer...
February 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28131786/buparlisib-and-paclitaxel-in-patients-with-platinum-pretreated-recurrent-or-metastatic-squamous-cell-carcinoma-of-the-head-and-neck-beril-1-a-randomised-double-blind-placebo-controlled-phase-2-trial
#16
Denis Soulières, Sandrine Faivre, Ricard Mesía, Éva Remenár, Shau-Hsuan Li, Andrey Karpenko, Arunee Dechaphunkul, Sebastian Ochsenreither, Laura Anna Kiss, Jin-Ching Lin, Raj Nagarkar, László Tamás, Sung-Bae Kim, Jozsef Erfán, Anna Alyasova, Stefan Kasper, Carlo Barone, Sabine Turri, Arunava Chakravartty, Marie Chol, Paola Aimone, Samit Hirawat, Lisa Licitra
BACKGROUND: Phosphatidylinositol 3-kinase (PI3K) pathway activation in squamous cell carcinoma of the head and neck contributes to treatment resistance and disease progression. Buparlisib, a pan-PI3K inhibitor, has shown preclinical antitumour activity and objective responses in patients with epithelial malignancies. We assessed whether the addition of buparlisib to paclitaxel improves clinical outcomes compared with paclitaxel and placebo in patients with recurrent or metastatic squamous cell carcinoma of the head and neck...
January 25, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28131211/potential-pathophysiological-pathways-that-can-explain-the-positive-effects-of-exercise-on-fatigue-in-multiple-sclerosis-a-scoping-review
#17
REVIEW
Martin Langeskov-Christensen, Etienne J Bisson, Marcia L Finlayson, Ulrik Dalgas
BACKGROUND: Fatigue is one of the most common and most disabling symptoms of multiple sclerosis (MS). It is a multidimensional and complex symptom with multifaceted origins, involving both central and peripheral fatigue mechanisms. Exercise has proven to be safe for people with MS, with cumulating evidence supporting significant reductions in fatigue. However, the potential pathophysiological pathways that can explain the positive effects of exercise on fatigue in MS remain elusive. OBJECTIVES: The objectives were, in PwMS (1) to update the knowledge on the pathophysiology underlying primary and secondary fatigue, and (2) to discuss potential pathophysiological pathways that can explain the positive effects of exercise on MS fatigue...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28128441/restrictive-versus-liberal-red-blood-cell-transfusion-strategies-for-people-with-haematological-malignancies-treated-with-intensive-chemotherapy-or-radiotherapy-or-both-with-or-without-haematopoietic-stem-cell-support
#18
REVIEW
Lise J Estcourt, Reem Malouf, Marialena Trivella, Dean A Fergusson, Sally Hopewell, Michael F Murphy
BACKGROUND: Many people diagnosed with haematological malignancies experience anaemia, and red blood cell (RBC) transfusion plays an essential supportive role in their management. Different strategies have been developed for RBC transfusions. A restrictive transfusion strategy seeks to maintain a lower haemoglobin level (usually between 70 g/L to 90 g/L) with a trigger for transfusion when the haemoglobin drops below 70 g/L), whereas a liberal transfusion strategy aims to maintain a higher haemoglobin (usually between 100 g/L to 120 g/L, with a threshold for transfusion when haemoglobin drops below 100 g/L)...
January 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28126025/anti-inflammatory-properties-of-amniotic-membrane-patch-following-pericardiectomy-for-constrictive-pericarditis
#19
Katherine M Marsh, Alice S Ferng, Tia Pilikian, Ankit A Desai, Ryan Avery, Mark Friedman, Isabel Oliva, Clint Jokerst, David Schipper, Zain Khalpey
BACKGROUND: Since constrictive pericarditis is most often idiopathic and the pathophysiology remains largely unknown, both the diagnosis and the treatment can be challenging. However, by definition, inflammatory processes are central to this disease process. Amniotic membrane patches have been shown to possess anti-inflammatory properties and are believed to be immune privileged. Due to these properties, amniotic membrane patches were applied intraoperatively in a complicated patient presenting with constrictive pericarditis...
January 26, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28124663/validation-of-the-1-%C3%AE-g-short-synacthen-test-an-assessment-of-morning-cortisol-cut-off-values-and-other-predictors
#20
F T Perton, G S Mijnhout, B J Kollen, J M M Rondeel, A A M Franken, P H P Groeneveld
BACKGROUND: Clinical practice shows that many low-dose short synacthen tests (LD-SSTs) for diagnosing adrenal insufficiency in an outpatient setting have a normal outcome and could be considered superfluous. The objective of this study is to provide a guideline to safely reduce the number of unnecessarily performed LD-SSTs. METHODS: Data of LD-SSTs performed in outpatients were collected. Optimal morning cortisol cut-off values were determined using ROC analysis...
January 2017: Netherlands Journal of Medicine
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