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https://www.readbyqxmd.com/read/28723609/failure-analysis-of-eleven-gates-glidden-drills-that-fractured-intraorally-during-post-space-preparation-a-retrieval-analysis-study
#1
Youssef S Al Jabbari, Raymond Fournelle, Sara M Al Taweel, Spiros Zinelis
The purpose of this study was to determine the failure mechanism of clinically failed Gates Glidden (GG) drills. Eleven retrieved GG drills (sizes #1 to #3) which fractured during root canal preparation were collected and the fracture location was recorded based on macroscopic observation. All fracture surfaces were investigated by a SEM. Then the fractured parts were embedded in acrylic resin and after metallographic preparation, the microstructure and elemental composition was evaluated by SEM and EDS. The Vickers hardness (HV) of all specimens was also determined...
July 19, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28723375/the-effects-of-exercise-on-fatigue-quality-of-life-and-psychological-function-for-men-with-prostate-cancer-systematic-review-and-meta-analyses
#2
REVIEW
Vishal Vashistha, Balwinder Singh, Sukhdeep Kaur, Larry J Prokop, Dharam Kaushik
CONTEXT: Conflicting data exists on the role of exercise interventions in patients with prostate cancer (PCa) regarding quality of life (QOL) endpoints. OBJECTIVE: To evaluate the effects of exercise interventions on fatigue, QOL, depression, and anxiety in PCa patients. EVIDENCE ACQUISITION: We searched seven major databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Web of Science, and Scopus) for randomized control trials (RCTs) of supervised exercise interventions for men with PCa from database inception to October 2015...
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28722815/influence-of-morphine-and-naloxone-on-pain-modulation-in-rheumatoid-arthritis-chronic-fatigue-syndrome-fibromyalgia-and-controls-a-double-blind-randomized-placebo-controlled-cross-over-study
#3
Linda Hermans, Jo Nijs, Patrick Calders, Luc De Clerck, Greta Moorkens, Guy Hans, Sofie Grosemans, Tine Roman De Mettelinge, Joanna Tuynman, Mira Meeus
BACKGROUND: Impaired pain inhibitory and enhanced pain facilitatory mechanisms are repeatedly reported in patients with central sensitization pain. However, the exact effects of frequently prescribed opioids on central pain modulation are still unknown. METHODS: A randomized, double-blind, placebo-controlled cross-over trial was carried out. Ten CFS/FM patients, 11 RA patients and 20 controls were randomly allocated to the experimental (10 mg morphine or 0.2 mg/ml Naloxone) and placebo (2 ml Aqua) group...
July 19, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28721216/switch-to-restoration-therapy-in-a-testosterone-treated-central-hypogonadism-with-erythrocytosis
#4
B Cangiano, C Cacciatore, L Persani, M Bonomi
We describe a case of severe erythrocytosis caused by testosterone replacement therapy in a 66-year-old man affected with hypogonadotropic hypogonadism (HH) determining osteoporosis, resolved by switching to restoration therapy with clomiphene citrate. The patient complained fatigue, loss of libido and defective erections and a spontaneous vertebral fracture despite bisphosphonate therapy and vitamin D supplementation. The examinations proved isolated HH and he was therefore treated with testosterone gel with regression of specific manifestations but elevated hemoglobin and hematocrit values...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28721049/the-potential-role-of-vagus-nerve-stimulation-in-the-treatment-of-hiv-associated-depression-a-review-of-literature
#5
REVIEW
William C Nicholson, Mirjam-Colette Kempf, Linda Moneyham, David E Vance
Depression is the most common comorbidity and neuropsychiatric complication in HIV. Estimates suggest that the prevalence rate for depression among HIV-infected individuals is three times that of the general population. The association between HIV and clinical depression is complex; however, chronic activation of inflammatory mechanisms, which disrupt central nervous system (CNS) function, may contribute to this association. Disruptions in CNS function can result in cognitive disorders, social withdrawal, fatigue, apathy, psychomotor impairment, and sleep disturbances, which are common manifestations in depression and HIV alike...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28720215/autoimmune-meningitis-and-encephalitis-in-adult-onset-still-disease-case-report
#6
Bożek Milena, Konopko Magdalena, Wierzba-Bobrowicz Teresa, Witkowski Grzegorz, Makowicz Grzegorz, Sienkiewicz-Jarosz Halina
INTRODUCTION: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disease of unknown cause. Its symptoms usually include persistent fever, fugitive salmon-colored rash, arthritis, sore throat (not specific), but it may also lead to internal organs' involvement, which presents with enlargement of the liver and spleen, swollen lymph nodes, carditis or pleuritis - potentially life-threatening complications. In rare cases, AOSD can cause aseptic meningitis or/and encephalitis...
July 8, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28716914/metabolic-profiles-of-exercise-in-patients-with-mcardle-disease-or-mitochondrial-myopathy
#7
Nigel F Delaney, Rohit Sharma, Laura Tadvalkar, Clary B Clish, Ronald G Haller, Vamsi K Mootha
McArdle disease and mitochondrial myopathy impair muscle oxidative phosphorylation (OXPHOS) by distinct mechanisms: the former by restricting oxidative substrate availability caused by blocked glycogen breakdown, the latter because of intrinsic respiratory chain defects. We applied metabolic profiling to systematically interrogate these disorders at rest, when muscle symptoms are typically minimal, and with exercise, when symptoms of premature fatigue and potential muscle injury are unmasked. At rest, patients with mitochondrial disease exhibit elevated lactate and reduced uridine; in McArdle disease purine nucleotide metabolites, including xanthine, hypoxanthine, and inosine are elevated...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28716692/the-fatigue-of-a-full-body-resistance-exercise-session-in-trained-men
#8
Paul W M Marshall, Rebecca Cross, Michael Haynes
OBJECTIVES: We examined the fatigue and recovery for 48h following a full-body resistance exercise session in trained men. DESIGN: Experimental cross-sectional study. METHODS: Eight resistance trained men volunteered to participate (mean±SD; age 27.0±6.0 years, height 1.79±0.05m, weight 81.8±6.8kg, training experience 7.8±5.0 years). Fatigue and pain was measured before, after, 1h post, 24h and 48h post the full-body resistance exercise session, which was based on in-season models used in contact team sports (e...
July 4, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28715597/the-proposal-of-a-clinical-protocol-to-assess-central-and-peripheral-fatigue-in-myotonic-dystrophy-type-1
#9
S Baldanzi, G Ricci, M Bottari, L Chico, C Simoncini, G Siciliano
DM1 is an autosomal-dominant disorder characterized by muscle weakness, myotonia, and multisystemic involvement. According to current literature fatigue and daytime sleepiness are among the main symptoms of DM1. Oxidative stress has been proposed to be one of the pathogenic factors of fatigue consequent to DM1. In this study, we investigated the dimensions of experienced fatigue and  physiological fatigue in a sample of 26 DM1 patients (17 males, 9 females, mean age 41.6 years, SD±12.7); experienced fatigue has been studied through Fatigue Severity Scale (FSS), and physiological fatigue was measured through an intermittent incremental exercise of the forearm muscles using a myometer; oxidative stress balance markers trend during aerobic exercise test have been collected...
July 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/28714825/quadriceps-and-patient-reported-function-in-acl-reconstructed-patients-a-principal-component-analysis
#10
Grant E Norte, Jay N Hertel, Susan A Saliba, David R Diduch, Joseph M Hart
CONTEXT: Assessment of physical function for individuals after ACL reconstruction (ACL-R) is complex and warrants the use of diverse evaluation strategies. To maximize the efficiency of assessment, there is a need to identify tests that provide the most meaningful information about this population. OBJECTIVE: To investigate underlying constructs of quadriceps muscle function that uniquely describe aspects of performance in patients after ACL-R, and establish clinical thresholds for measures able to classify patients with and without ACL-R...
July 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28712263/effects-of-colostrum-serum-on-the-serotonergic-system-in-the-dorsal-raphe-nuclei-of-exercised-rats
#11
Tae-Woon Kim, Chang-Ju Kim, Jinhee Seo
PURPOSE: The central fatigue hypothesis suggests that exhaustion, or the maximum level of exercise, induces excessive stress and increases serotonin concentrations in the brain, which in turn decreases central nervous system (CNS) function and induces fatigue. Our aim was to determine the effects of colostrum serum on the serotonergic system in the dorsal raphe nuclei during exhaustive exercise. METHODS: Animals were randomly divided into five groups: control, exercise, exercise and treatment with 50, 100, and 200 mg/kg of colostrum serum...
March 31, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28708702/exercise-induced-fatigue-in-severe-hypoxia-following-an-intermittent-hypoxic-protocol
#12
Rosie Twomey, James Wrightson, Hannah Fletcher, Stephanie Avraam, Emma Ross, Jeanne Dekerle
PURPOSE: Exercise-induced central fatigue is alleviated following acclimatisation to high altitude. The adaptations underpinning this effect may also be induced with brief, repeated exposures to severe hypoxia. The purpose of this study was to determine whether (i) exercise tolerance in severe hypoxia would be improved following an intermittent hypoxic (IH) protocol and (ii) exercise-induced central fatigue would be alleviated following an IH protocol. METHODS: Nineteen recreationally-active males were randomised into two groups who completed ten 2-h exposures in severe hypoxia (IH: PIO2 82 mmHg; n=11) or normoxia (control; n=8)...
July 13, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28708236/psychosocial-interventions-for-fatigue-during-cancer-treatment-with-palliative-intent
#13
REVIEW
Hanneke Poort, Marlies Peters, Gijs Bleijenberg, Marieke Fm Gielissen, Martine Margaretha Goedendorp, Paul Jacobsen, Stans Verhagen, Hans Knoop
BACKGROUND: Fatigue is a prevalent and burdensome symptom for patients with incurable cancer receiving cancer treatment with palliative intent and is associated with reduced quality of life. Psychosocial interventions seem promising for management of fatigue among cancer patients. OBJECTIVES: To assess the effects of psychosocial interventions for fatigue in adult patients with incurable cancer receiving cancer treatment with palliative intent. SEARCH METHODS: We searched the following databases: CENTRAL, MEDLINE, Embase, CINAHL, PsycINFO, and seven clinical trial registries; we also searched the reference lists of articles...
July 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28705910/fatigability-exercise-intolerance-and-abnormal-skeletal-muscle-energetics-in-heart-failure
#14
Kilian Weiss, Michael Schär, Gurusher S Panjrath, Yi Zhang, Kavita Sharma, Paul A Bottomley, Asieh Golozar, Angela Steinberg, Gary Gerstenblith, Stuart D Russell, Robert G Weiss
BACKGROUND: Among central and peripheral factors contributing to exercise intolerance (EI) in heart failure (HF), the extent to which skeletal muscle (SM) energy metabolic abnormalities occur and contribute to EI and increased fatigability in HF patients with reduced or preserved ejection fraction (HFrEF and HFpEF, respectively) are not known. An energetic plantar flexion exercise fatigability test and magnetic resonance spectroscopy were used to probe the mechanistic in vivo relationships among SM high-energy phosphate concentrations, mitochondrial function, and EI in HFrEF and HFpEF patients and in healthy controls...
July 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28705307/a-new-method-for-enhanced-expectoration-of-sputum-by-vibratory-stimulation-of-the-cervical-trachea
#15
Mitsuhiro Kamimura, Nobuhisa Kameyama, Chie Homma, Tatsuya Ibe, Shinjiro Takeoka, Atsuto Mouri, Yoichiro Hamamoto
BACKGROUND: Expectoration of sputum can be difficult for patients with respiratory conditions such as chronic obstructive pulmonary disease, chronic bronchitis, or bronchiectasis because of the effects of decreased pulmonary function, respiratory muscle fatigue, altered sputum properties, and impaired ciliary function. We developed a new method for the vibratory stimulation of the cervical trachea and this study aimed to compare it with the Acapella (a current oscillation device) method...
July 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28704311/acute-neuromuscular-and-endocrine-responses-to-two-different-compound-exercises-squat-versus-deadlift
#16
Matthew J Barnes, Adam Miller, Daniel Reeve, Robin Jc Stewart
Anecdotally, it is believed that the deadlift exercise brings about greater levels of central fatigue than other exercises; however no empirical evidence exists to support this view. Additionally, little is known about the acute endocrine response to heavy deadlift exercise and how this may differ to other similar compound exercises. Therefore, the aim of this study was to identify and compare the acute, neuromuscular and endocrine responses to squat and deadlift exercise. Ten resistance trained males completed 8 sets of 2 repetitions at 95 % of one repetition maximum...
July 12, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28699493/hallucinations-associated-with-topiramate-therapy-a-case-report-and-review-of-the-literature
#17
Shelby L Register, Orlando L Ruano, Deborah L Sanchez, Glenn Catalano, Maria C Catalano
BACKGROUND: Topiramate is a medication that is approved as both monotherapy and adjunctive treatment of seizure disorder in adults and adolescents. It is also approved for migraine prophylaxis. It has been associated with many side effects, including weight loss and the development of renal stones. It has also been associated with various central nervous system side effects such as dizziness, nervousness, parasthesias, and fatigue. Less commonly, it has been associated with the development of psychotic symptoms such as hallucinations...
July 10, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28689594/patient-reported-outcomes-and-fatigue-in-patients-with-chronic-hepatitis-c-infection
#18
REVIEW
Pegah Golabi, Mehmet Sayiner, Haley Bush, Lynn H Gerber, Zobair M Younossi
Fatigue is a common symptom. Diagnosis is difficult. Fatigue is often a complex symptom. In the recent years, fatigue has gained considerable amount of attention. It has 2 major types, central and peripheral, which may occur together or alone. Although fatigue has many strong relations with depression and sleep disorders, it is a separate entity. For the diagnosis of fatigue, self-reports and patient-reported outcomes are highly valuable tools because these methods can reflect patients' perceptions. Treating the underlying disease with newly developed direct-acting antivirals often improves the perceived fatigue...
August 2017: Clinics in Liver Disease
https://www.readbyqxmd.com/read/28689591/neurologic-manifestations-of-hepatitis-c-virus-infection
#19
REVIEW
Sentia Iriana, Michael P Curry, Nezam H Afdhal
The extrahepatic manifestations of hepatitis C include effects on the central nervous system, which have been associated with the ability of hepatitis C virus (HCV) to replicate in microglial and endothelial cells and the chronic inflammation induced by HCV. HCV can induce impaired neurocognition, which is clinically manifested by impaired quality of life, fatigue, and brain fog. These cognitive defects can be present even in patients with mild histologic HCV and have been confirmed by neurocognitive testing and brain imaging by magnetic resonance spectroscopy...
August 2017: Clinics in Liver Disease
https://www.readbyqxmd.com/read/28687954/cortical-voluntary-activation-testing-methodology-impacts-central-fatigue
#20
José Mira, Thomas Lapole, Robin Souron, Laurent Messonnier, Guillaume Y Millet, Thomas Rupp
PURPOSE: Currently, cortical voluntary activation (VATMS) is assessed by superimposing transcranial magnetic stimulation (TMS) on a maximal voluntary contraction (MVC), 75% MVC and 50% MVC, each contraction being interspersed with 5-10 s of relaxation. Here, we assessed whether this traditional approach (TRADI) underestimates central fatigue due to this short recovery compared to a continuous method (CONTI). METHODS: VATMS, motor-evoked potential (MEP), and cortical silent period (CSP) of the vastus lateralis were determined in 12 young healthy adults before and after a 2-min sustained MVC of knee extensors in two randomly assigned sessions...
July 7, 2017: European Journal of Applied Physiology
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