keyword
https://read.qxmd.com/read/38239239/-not-available
#21
REVIEW
Michał K Jastrzębski, Piotr Wójcik, Piotr Stępnicki, Agnieszka A Kaczor
Neurons are believed to be non-proliferating cells. However, neuronal stem cells are still present in certain areas of the adult brain, although their proliferation diminishes with age. Just as with other cells, their proliferation and differentiation are modulated by various mechanisms. These mechanisms are foundational to the strategies developed to induce neuronal proliferation and differentiation, with potential therapeutic applications for neurodegenerative diseases. The most common among these diseases are Parkinson's disease and Alzheimer's disease, associated with the formation of β -amyloid (A β ) aggregates which cause a reduction in the number of neurons...
January 2024: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/38218125/synthesis-biological-activity-evaluation-and-mechanism-analysis-of-new-ganglioside-gm3-derivatives-as-potential-agents-for-nervous-functional-recovery
#22
JOURNAL ARTICLE
Yingjun Lin, Juntao Wang, Xiangwen Liu, Yangfan Hu, Yong Zhang, Faqin Jiang
Neuronal regenerative ability is vital for the treatment of neurodegenerative diseases and neuronal injuries. Recent studies have revealed that Ganglioside GM3 and its derivatives may possess potential neuroprotective and neurite growth-promoting activities. Herein, six GM3 derivatives were synthesized and evaluated their potential neuroprotective effects and neurite outgrowth-promoting activities on a cellular model of Parkinson's disease and primary nerve cells. Amongst these derivatives, derivatives N-14 and 2C-12 demonstrated neuroprotective effects in the MPP + model in SH-SY5Y cells...
January 3, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38215353/patient-with-parkinson-disease-and-care-partner-perceptions-of-key-domains-affecting-health-related-quality-of-life
#23
JOURNAL ARTICLE
Michelle H Tosin, Christopher G Goetz, Glenn T Stebbins
BACKGROUND AND OBJECTIVES: To effectively customize Parkinson disease (PD) programs, it is important to incorporate the "individual's voice" and have a thorough understanding of the symptom priorities of people with PD (PwP) and care partners (CP). In this convergent integrated mixed-method systematic review, we aimed to analyze qualitative and quantitative evidence of PD motor and nonmotor symptoms affecting health-related quality of life (HRQOL) in PwP and CP, comparing priorities across different levels of disease severity...
February 13, 2024: Neurology
https://read.qxmd.com/read/38130373/neuronal-type-specific-epigenome-editing-to-decrease-snca-expression-implications-for-precision-medicine-in-synucleinopathies
#24
JOURNAL ARTICLE
Zhiguo Sun, Boris Kantor, Ornit Chiba-Falek
Overexpression of SNCA has been implicated in the pathogenesis of synucleinopathies, particularly Parkinson's disease (PD) and dementia with Lewy bodies (DLB). While PD and DLB share some clinical and pathological similarities, each disease presents distinct characteristics, including the primary affected brain region and neuronal type. We aimed to develop neuronal-type-specific SNCA -targeted epigenome therapies for synucleinopathies. The system is based on an all-in-one lentiviral vector comprised of CRISPR-d Sa Cas9 and guide RNA (gRNA) targeted at SNCA intron 1 fused with a synthetic repressor molecule of Krüppel-associated box (KRAB)/ methyl CpG binding protein 2 (MeCp2) transcription repression domain (TRD)...
March 12, 2024: Molecular Therapy. Nucleic Acids
https://read.qxmd.com/read/38116736/a-closer-look-at-amyloid-ligands-and-what-they-tell-us-about-protein-aggregates
#25
REVIEW
Timothy S Chisholm, Christopher A Hunter
The accumulation of amyloid fibrils is characteristic of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease. Detecting these fibrils with fluorescent or radiolabelled ligands is one strategy for diagnosing and better understanding these diseases. A vast number of amyloid-binding ligands have been reported in the literature as a result. To obtain a better understanding of how amyloid ligands bind, we have compiled a database of 3457 experimental dissociation constants for 2076 unique amyloid-binding ligands...
December 20, 2023: Chemical Society Reviews
https://read.qxmd.com/read/38116678/the-michael-j-fox-foundation-s-quest-for-a-cure-for-parkinson-s-disease-an-interview-with-nicole-polinski
#26
JOURNAL ARTICLE
Nicole K Polinski
No abstract text is available yet for this article.
December 1, 2023: Disease Models & Mechanisms
https://read.qxmd.com/read/38104147/prediction-of-dyskinesia-in-parkinson-s-disease-patients-using-machine-learning-algorithms
#27
JOURNAL ARTICLE
Denisson Augusto Bastos Leal, Carla Michele Vieira Dias, Rodrigo Pereira Ramos, Ivani Brys
Dyskinesias are non preventable abnormal involuntary movements that represent the main challenge of the long term treatment of Parkinson's disease (PD) with the gold standard dopamine precursor levodopa. Applying machine learning techniques on the data extracted from the Parkinson's Progression Marker Initiative (PPMI, Michael J. Fox Foundation), this study was aimed to identify PD patients who are at high risk of developing dyskinesias. Data regarding clinical, behavioral and neurological features from 697 PD patients were included in our study...
December 16, 2023: Scientific Reports
https://read.qxmd.com/read/38099928/sensitized-emission-imaging-allows-nanoscale-surface-polarity-mapping-of-%C3%AE-synuclein-amyloid-fibrils
#28
JOURNAL ARTICLE
Jaladhar Mahato, Rajat Mukherjee, Abhik Bose, Surabhi Mehra, Laxmikant Gadhe, Samir K Maji, Arindam Chowdhury
When misfolded, α-Synuclein (α-Syn), a natively disordered protein, aggregates to form amyloid fibrils responsible for the neurodegeneration observed in Parkinson's disease. Structural studies revealed distinct molecular packing of α-Syn in different fibril polymorphs and variations of interprotofilament connections in the fibrillar architecture. Fibril polymorphs have been hypothesized to exhibit diverse surface polarities depending on the folding state of the protein during aggregation; however, the spatial variation of surface polarity in amyloid fibrils remains unexplored...
December 15, 2023: ACS Chemical Neuroscience
https://read.qxmd.com/read/38094162/a-novel-transcranial-photobiomodulation-device-to-address-motor-signs-of-parkinson-s-disease-a-parallel-randomised-feasibility-study
#29
JOURNAL ARTICLE
Geoffrey Herkes, Claire McGee, Ann Liebert, Brian Bicknell, Vivian Isaac, Hosen Kiat, Craig S McLachlan
BACKGROUND: Parkinson's disease is a progressive neurological disease with limited treatment options. Animal models and a proof-of-concept case series have suggested that photobiomodulation may be an effective adjunct treatment for the symptoms of Parkinson's disease. The aim was to determine the safety and feasibility of transcranial photobiomodulation (tPBM) to reduce the motor signs of Parkinson's disease. METHODS: In this double-blind, randomised, sham-controlled feasibility trial, patients (aged 59-85 years) with idiopathic Parkinson's disease were treated with a tPBM helmet for 12 weeks (72 treatments with either active or sham therapy; stage 1)...
December 2023: EClinicalMedicine
https://read.qxmd.com/read/38081299/transport-and-inhibition-mechanisms-of-human-vmat2
#30
JOURNAL ARTICLE
Di Wu, Qihao Chen, Zhuoya Yu, Bo Huang, Jun Zhao, Yuhang Wang, Jiawei Su, Feng Zhou, Rui Yan, Na Li, Yan Zhao, Daohua Jiang
Vesicular monoamine transporter 2 (VMAT2) accumulates monoamines in presynaptic vesicles for storage and exocytotic release, playing a vital role in monoaminergic neurotransmission1-3 . Dysfunction of monoaminergic systems causes many neurological and psychiatric disorders, including Parkinson's disease, hyperkinetic movement disorders, and depression4-6 . Suppressing VMAT2 by reserpine and tetrabenazine alleviates symptoms of hypertension and Huntington's disease7,8 , respectively. Here, we describe the cryo-electron microscopy structures of human VMAT2 complexed with serotonin and three clinical drugs at 3...
December 11, 2023: Nature
https://read.qxmd.com/read/38056239/artemisinin-protects-dopaminergic-neurons-against-1-methyl-4-phenyl-1-2-3-6-tetrahydropyridine-induced-neurotoxicity-in-a-mouse-model-of-parkinson-s-disease
#31
JOURNAL ARTICLE
Hye-Sun Lim, Gunhyuk Park
Artemisinin is an antimalarial drug that has been used for almost half a century. However, the anti-Parkinson's disease (PD) effects of artemisinin with respect to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced oxidative stress have not yet been investigated while focusing on NF-E2-related factor 2 (Nrf2) signaling. Thus, we sought to assess the behavioral and oxidative mechanistic effects of artemisinin on MPTP-induced toxicity via the Nrf2 signaling pathway. We explored this through immunohistochemical assays, ELISA, in differentiated PC12 cells treated with siRNA, and with a PD mouse model...
December 5, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38042680/eye-movements-in-parkinson-s-disease-from-neurophysiological-mechanisms-to-diagnostic-tools
#32
REVIEW
Chrystalina A Antoniades, Miriam Spering
Movement disorders such as Parkinson's disease (PD) impact oculomotor function - the ability to move the eyes accurately and purposefully to serve a multitude of sensory, cognitive, and secondary motor tasks. Decades of neurophysiological research in monkeys and behavioral studies in humans have characterized the neural basis of healthy oculomotor control. This review links eye movement abnormalities in persons living with PD to the underlying neurophysiological mechanisms and pathways. Building on this foundation, we highlight recent progress in using eye movements to gauge symptom severity, assess treatment effects, and serve as potential precision biomarkers...
December 1, 2023: Trends in Neurosciences
https://read.qxmd.com/read/38022070/unmasking-uremic-encephalopathy-choreoathetoid-movements-mimicking-alcohol-withdrawal-in-a-person-with-an-alcohol-use-disorder
#33
Keyur Saboo, Rinkle Gemnani, Sourya Acharya, Sunil Kumar, Tushar Sontakke
Chorea is a disorder characterized by irregular, involuntary movements affecting the limbs, trunk, neck, or face. It can be a significant symptom in various neurologic diseases, including metabolic, autoimmune, and neurodegenerative conditions. The neural foundation that underlies the genesis of chorea appears to be fairly diverse, even though its pathophysiology is frequently associated with the malfunctioning of inhibitory circuits within the basal ganglia. Movement disorders such as tremors, myoclonus, ataxia, chorea, and Parkinsonism may arise due to renal dysfunction or complications from management like renal transplant and hemodialysis...
October 2023: Curēus
https://read.qxmd.com/read/38020756/modeling-of-cerebellar-transcranial-electrical-stimulation-effects-on-hand-tremor-in-parkinson-s-disease
#34
JOURNAL ARTICLE
Soraya Rahimi, Farzad Towhidkhah, Golnaz Baghdadi, Bijan Forogh, Payam Saadat, Ghazaleh Soleimani, Seyed Amirhassan Habibi
INTRODUCTION: Parkinson's disease (PD) is a neurodegenerative disorder with different motor and neurocognitive symptoms. Tremor is a well-known symptom of this disease. Increasing evidence suggested that the cerebellum may substantially contribute to tremors as a clinical symptom of PD. However, the theoretical foundations behind these observations are not yet fully understood. METHODS: In this study, a computational model is proposed to consider the role of the cerebellum and to show the effectiveness of cerebellar transcranial alternating current stimulation (tACS) on the rest tremor in participants with PD...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/37992927/recombinant-human-hspb5-acd-structural-domain-inhibits-neurotoxicity-by-regulating-pathological-%C3%AE-syn-aggregation
#35
JOURNAL ARTICLE
Chang Liu, Xuying Ding, Xiao Guo, Meijun Zhao, Xiaojun Zhang, Ziqing Li, Risheng Zhao, Yuyan Cao, Jiaying Xing
The treatment of Parkinson's disease is a global medical challenge. α-Synuclein (α-Syn) is the causative protein in Parkinson's disease and is closely linked to its progression. Therefore, inhibiting the pathological aggregation of α-Syn and its neurotoxicity is essential for the treatment of Parkinson's disease. In this study, α-Syn and recombinant human HspB5-ACD structural domain protein (AHspB5) were produced using the BL21(DE3) E. coli prokaryotic expression system, and then the role and mechanism of AHspB5 in inhibiting the pathological aggregation of α-Syn and its neurotoxicity were investigated...
November 20, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37986864/multi-night-cortico-basal-recordings-reveal-mechanisms-of-nrem-slow-wave-suppression-and-spontaneous-awakenings-at-high-temporal-resolution-in-parkinson-s-disease
#36
Md Fahim Anjum, Clay Smyth, Derk-Jan Dijk, Philip Starr, Timothy Denison, Simon Little
Background Sleep disturbance is a prevalent and highly disabling comorbidity in individuals with Parkinson's disease (PD) that leads to worsening of daytime symptoms, reduced quality of life and accelerated disease progression. Objectives We aimed to record naturalistic overnight cortico-basal neural activity in people with PD, in order to determine the neurophysiology of spontaneous awakenings and slow wave suppression in non-rapid eye movement (NREM) sleep, towards the development of novel sleep-targeted neurostimulation therapies...
November 7, 2023: Research Square
https://read.qxmd.com/read/37964598/-be-sustainable-eosc-life-recommendations-for-implementation-of-fair-principles-in-life-science-data-handling
#37
JOURNAL ARTICLE
Romain David, Arina Rybina, Jean-Marie Burel, Jean-Karim Heriche, Pauline Audergon, Jan-Willem Boiten, Frederik Coppens, Sara Crockett, Katrina Exter, Sven Fahrner, Maddalena Fratelli, Carole Goble, Philipp Gormanns, Tobias Grantner, Björn Grüning, Kim Tamara Gurwitz, John M Hancock, Henriette Harmse, Petr Holub, Nick Juty, Geoffrey Karnbach, Emma Karoune, Antje Keppler, Jessica Klemeier, Carla Lancelotti, Jean-Luc Legras, Allyson L Lister, Dario Livio Longo, Rebecca Ludwig, Bénédicte Madon, Marzia Massimi, Vera Matser, Rafaele Matteoni, Michaela Th Mayrhofer, Christian Ohmann, Maria Panagiotopoulou, Helen Parkinson, Isabelle Perseil, Claudia Pfander, Roland Pieruschka, Michael Raess, Andreas Rauber, Audrey S Richard, Paolo Romano, Antonio Rosato, Alex Sánchez-Pla, Susanna-Assunta Sansone, Ugis Sarkans, Beatriz Serrano-Solano, Jing Tang, Ziaurrehman Tanoli, Jonathan Tedds, Harald Wagener, Martin Weise, Hans V Westerhoff, Rudolf Wittner, Jonathan Ewbank, Niklas Blomberg, Philip Gribbon
The main goals and challenges for the life science communities in the Open Science framework are to increase reuse and sustainability of data resources, software tools, and workflows, especially in large-scale data-driven research and computational analyses. Here, we present key findings, procedures, effective measures and recommendations for generating and establishing sustainable life science resources based on the collaborative, cross-disciplinary work done within the EOSC-Life (European Open Science Cloud for Life Sciences) consortium...
November 15, 2023: EMBO Journal
https://read.qxmd.com/read/37954904/a-neuroimaging-biomarker-for-individual-brain-related-abnormalities-in-neurodegeneration-ibrain-a-cross-sectional-study
#38
JOURNAL ARTICLE
Kun Zhao, Pindong Chen, Aaron Alexander-Bloch, Yongbin Wei, Martin Dyrba, Fan Yang, Xiaopeng Kang, Dawei Wang, Dongsheng Fan, Shan Ye, Yi Tang, Hongxiang Yao, Bo Zhou, Jie Lu, Chunshui Yu, Pan Wang, Zhengluan Liao, Yan Chen, Longjian Huang, Xi Zhang, Ying Han, Shuyu Li, Yong Liu
BACKGROUND: Alzheimer's disease (AD) is a prevalent neurodegenerative disorder that poses a worldwide public health challenge. A neuroimaging biomarker would significantly improve early diagnosis and intervention, ultimately enhancing the quality of life for affected individuals and reducing the burden on healthcare systems. METHODS: Cross-sectional and longitudinal data (10,099 participants with 13,380 scans) from 12 independent datasets were used in the present study (this study was performed between September 1, 2021 and February 15, 2023)...
November 2023: EClinicalMedicine
https://read.qxmd.com/read/37952272/ethnoracial-differences-for-caregiving-burden-in-parkinson-s-disease
#39
JOURNAL ARTICLE
Ece Bayram, Hongliang Liu, Sheng Luo, Daniel G Di Luca, Michael Skipworth, Lisa Damron Solomon, Nabila Dahodwala, Irene Litvan
INTRODUCTION: Caregivers play an important role in Parkinson's disease (PD) treatment, especially as the disease progresses. As the symptom profile and needs of people with PD (PwP) differ across ethnoracial groups, whether caregiving needs also differ for different ethnoracial groups should be investigated. METHODS: Data were obtained from the Parkinson's Foundation funded Parkinson's Outcomes Project for PwP identifying as Hispanic (n = 495), non-Hispanic Asian (n = 170), non-Hispanic Black (n = 162), or non-Hispanic White (n = 7687)...
January 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/37933060/comparison-of-updrs-iii-score-between-young-and-late-onset-parkinson-disease-after-deep-brain-stimulation-a-meta-analysis
#40
JOURNAL ARTICLE
Jae Meen Lee, Kyoungjune Pak
PURPOSE: Parkinson disease (PD) is a common age-related neurodegenerative disease. Subthalamic nucleus deep brain stimulation (DBS) is a safe and effective surgical treatment for medically resistant advanced PD. However, the relationship between the age at PD onset and the efficacy of subthalamic nucleus DBS surgery remains unclear. Thus, we conducted a meta-analysis to compare motor symptom improvements after DBS for the treatment of young-onset and late-onset PD. METHODS: We systematically searched the Medline and Embase databases (from inception to March 2023) for English publications...
November 3, 2023: Medicine (Baltimore)
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