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Parkinson's Foundation

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https://www.readbyqxmd.com/read/28108265/palliative-care-and-parkinson-s-disease-meeting-summary-and-recommendations-for-clinical-research
#1
REVIEW
Benzi M Kluger, Siobhán Fox, Suzanne Timmons, Maya Katz, Nicholas B Galifianakis, Indu Subramanian, Julie H Carter, Miriam J Johnson, Edward W Richfield, David Bekelman, Jean S Kutner, Janis Miyasaki
INTRODUCTION: Palliative care is an approach to caring for patients and families affected by serious illnesses that focuses on the relief of suffering through the management of medical symptoms, psychosocial issues, advance care planning and spiritual wellbeing. Over the past decade there has been an emerging clinical and research interest in the application of palliative care approaches to Parkinson's disease (PD) and outpatient palliative care services are now offered by several movement disorders centers...
January 11, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28087060/personality-in-parkinson-s-disease-clinical-behavioural-and-cognitive-correlates
#2
REVIEW
Gabriella Santangelo, Fausta Piscopo, Paolo Barone, Carmine Vitale
Affective disorders and personality changes have long been considered pre-motor aspects of Parkinson's disease (PD). Many authors have used the term "premorbid personality" to define distinctive features of PD patients' personality characterized by reduced exploration of new environmental stimuli or potential reward sources ("novelty seeking") and avoidance behaviour ("harm avoidance") present before motor features. The functional correlates underlying the personality changes described in PD, implicate dysfunction of meso-cortico-limbic and striatal circuits...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28069931/the-search-for-a-peripheral-biopsy-indicator-of-%C3%AE-synuclein-pathology-for-parkinson-disease
#3
REVIEW
John M Lee, Pascal Derkinderen, Jeffrey H Kordower, Roy Freeman, David G Munoz, Thomas Kremer, Wagner Zago, Samantha J Hutten, Charles H Adler, Geidy E Serrano, Thomas G Beach
The neuropathological hallmark of Parkinson disease (PD) is abnormal accumulation of α-synuclein (α-syn). Demonstrating pathological α-syn in live patients would be useful for identifying and monitoring PD patients. To date, however, imaging and biofluid approaches have not permitted premortem assessment of pathological α-syn. α-syn pathology in the peripheral nervous system of patients with PD has been demonstrated in studies dating back more than 40 years. More recent work suggests that colon, submandibular gland and skin biopsies could be useful as expedient biomarkers but histological differentiation of pathological and normal peripheral α-syn has been challenging and multiple research groups have reported variable results...
January 9, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28050656/the-recommendations-of-a-consensus-panel-for-the-screening-diagnosis-and-treatment-of-neurogenic-orthostatic-hypotension-and-associated-supine-hypertension
#4
REVIEW
Christopher H Gibbons, Peter Schmidt, Italo Biaggioni, Camille Frazier-Mills, Roy Freeman, Stuart Isaacson, Beverly Karabin, Louis Kuritzky, Mark Lew, Phillip Low, Ali Mehdirad, Satish R Raj, Steven Vernino, Horacio Kaufmann
Neurogenic orthostatic hypotension (nOH) is common in patients with neurodegenerative disorders such as Parkinson's disease, multiple system atrophy, pure autonomic failure, dementia with Lewy bodies, and peripheral neuropathies including amyloid or diabetic neuropathy. Due to the frequency of nOH in the aging population, clinicians need to be well informed about its diagnosis and management. To date, studies of nOH have used different outcome measures and various methods of diagnosis, thereby preventing the generation of evidence-based guidelines to direct clinicians towards 'best practices' when treating patients with nOH and associated supine hypertension...
January 3, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28008361/fuzzy-logic-based-risk-of-fall-estimation-using-smartwatch-data-as-a-means-to-form-an-assistive-feedback-mechanism-in-everyday-living-activities
#5
Dimitrios E Iakovakis, Fotini A Papadopoulou, Leontios J Hadjileontiadis
This Letter aims to create a fuzzy logic-based assistive prevention tool for falls, based on accessible sensory technology, such as smartwatch, resulting in monitoring of the risk factors of falls caused by orthostatic hypotension (OH); a drop in systolic blood pressure (DSBP) >20 mmHg due to postural changes. Epidemiological studies have shown that OH is a high risk factor for falls and has a strong impact in quality of life (QoL) of the elderly's, especially for some cases such as Parkinsonians. Based on smartwatch data, it is explored here how statistical features of heart rate variability (HRV) can lead to DSBP prediction and estimation of the risk of fall...
December 2016: Healthcare Technology Letters
https://www.readbyqxmd.com/read/27926449/the-role-of-dopamine-in-the-pathophysiology-and-treatment-of-apathy
#6
T T-J Chong, M Husain
Disorders of diminished motivation, such as apathy, are common and prevalent across a wide range of medical conditions, including Parkinson's disease, Alzheimer's dementia, stroke, depression, and schizophrenia. Such disorders have a significant impact on morbidity and quality of life, yet their management lacks consensus and remains unsatisfactory. Here, we review laboratory and clinical evidence for the use of dopaminergic therapies in the treatment of apathy. Dopamine is a key neurotransmitter that regulates motivated decision making in humans and other species...
2016: Progress in Brain Research
https://www.readbyqxmd.com/read/27911344/patient-perspectives-on-deep-brain-stimulation-clinical-research-in-early-stage-parkinson-s-disease
#7
Lauren Heusinkveld, Mallory Hacker, Maxim Turchan, Madelyn Bollig, Christina Tamargo, William Fisher, Lauren McLaughlin, Adria Martig, David Charles
The FDA approved a multicenter, double-blind, Phase III, pivotal trial testing deep brain stimulation in 280 people with very early stage Parkinson's disease (PD; IDE#G050016). In partnership with The Michael J. Fox Foundation for Parkinson's Research, we conducted a survey to investigate motivating factors, barriers, and gender differences for participation in a trial testing DBS in early PD. The majority of survey respondents (72%) indicated they would consider learning more about participating. Men and women with early PD are likely to consider enrolling in trials of invasive therapies that may slow symptom progression and help future patients...
November 30, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27865980/aging-of-cerebral-white-matter
#8
REVIEW
Huan Liu, Yuanyuan Yang, Yuguo Xia, Wen Zhu, Rehana K Leak, Zhishuo Wei, Jianyi Wang, Xiaoming Hu
White matter (WM) occupies a large volume of the human cerebrum and is mainly composed of myelinated axons and myelin-producing glial cells. The myelinated axons within WM are the structural foundation for efficient neurotransmission between cortical and subcortical areas. Similar to neuron-enriched gray matter areas, WM undergoes a series of changes during the process of aging. WM malfunction can induce serious neurobehavioral and cognitive impairments. Thus, age-related changes in WM may contribute to the functional decline observed in the elderly...
March 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/27858719/regular-exercise-quality-of-life-and-mobility-in-parkinson-s-disease-a%C3%A2-longitudinal-analysis-of-national-parkinson-foundation-quality-improvement-initiative-data
#9
Miriam R Rafferty, Peter N Schmidt, Sheng T Luo, Kan Li, Connie Marras, Thomas L Davis, Mark Guttman, Fernando Cubillos, Tanya Simuni
BACKGROUND: Research-based exercise interventions improve health-related quality of life (HRQL) and mobility in people with Parkinson's disease (PD). OBJECTIVE: To examine whether exercise habits were associated with changes in HRQL and mobility over two years. METHODS: We identified a cohort of National Parkinson Foundation Quality Improvement Initiative (NPF-QII) participants with three visits. HRQL and mobility were measured with the Parkinson's Disease Questionnaire (PDQ-39) and Timed Up and Go (TUG)...
November 14, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27716510/molecular-diversity-of-midbrain-development-in-mouse-human-and-stem-cells
#10
COMPARATIVE STUDY
Gioele La Manno, Daniel Gyllborg, Simone Codeluppi, Kaneyasu Nishimura, Carmen Salto, Amit Zeisel, Lars E Borm, Simon R W Stott, Enrique M Toledo, J Carlos Villaescusa, Peter Lönnerberg, Jesper Ryge, Roger A Barker, Ernest Arenas, Sten Linnarsson
Understanding human embryonic ventral midbrain is of major interest for Parkinson's disease. However, the cell types, their gene expression dynamics, and their relationship to commonly used rodent models remain to be defined. We performed single-cell RNA sequencing to examine ventral midbrain development in human and mouse. We found 25 molecularly defined human cell types, including five subtypes of radial glia-like cells and four progenitors. In the mouse, two mature fetal dopaminergic neuron subtypes diversified into five adult classes during postnatal development...
October 6, 2016: Cell
https://www.readbyqxmd.com/read/27692902/dnm3-and-genetic-modifiers-of-age-of-onset-in-lrrk2-gly2019ser-parkinsonism-a-genome-wide-linkage-and-association-study
#11
Joanne Trinh, Emil K Gustavsson, Carles Vilariño-Güell, Stephanie Bortnick, Jeanne Latourelle, Marna B McKenzie, Chelsea Szu Tu, Ekaterina Nosova, Jaskaran Khinda, Austen Milnerwood, Suzanne Lesage, Alexis Brice, Meriem Tazir, Jan O Aasly, Laura Parkkinen, Hazal Haytural, Tatiana Foroud, Richard H Myers, Samia Ben Sassi, Emna Hentati, Fatma Nabli, Emna Farhat, Rim Amouri, Fayçal Hentati, Matthew J Farrer
BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) mutation 6055G→A (Gly2019Ser) accounts for roughly 1% of patients with Parkinson's disease in white populations, 13-30% in Ashkenazi Jewish populations, and 30-40% in North African Arab-Berber populations, although age of onset is variable. Some carriers have early-onset parkinsonism, whereas others remain asymptomatic despite advanced age. We aimed to use a genome-wide approach to identify genetic variability that directly affects LRRK2 Gly2019Ser penetrance...
November 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27622968/medication-use-in-people-with-late-stage-parkinson-s-disease-and-parkinsonism-living-at-home-and-in-institutional-care-in-north-east-england-a-balance-of-symptoms-and-side-effects
#12
Annette Hand, William K Gray, Lloyd L Oates, Megan Woolford, Anna Todd, Elizabeth Bale, Catherine Jones, Brian H Wood, Richard W Walker
BACKGROUND: People with Parkinson's disease (PD) and parkinsonism living in care homes (residential or nursing care) in the UK represent around 10-15% of all people with PD and 3-5% of all care home residents. There are few previous data on medication use in those living in care homes with PD. In this study we aimed to compare medication use in a representative cohort of people with PD living in care homes in north-east England with those living in their own homes. METHOD: All people with late stage (Hoehn and Yahr III-V) idiopathic PD, PD dementia, or atypical parkinsonian syndromes under the care of the Northumbria Healthcare NHS Foundation Trust PD service on 1st January 2015 were identified...
September 2, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27505901/clinical-assessments-as-predictors-of-primary-on-road-outcomes-in-parkinson-s-disease
#13
Sherrilene Classen, Jeffrey D Holmes, Liliana Alvarez, Katherine Loew, Ashley Mulvagh, Kayla Rienas, Victoria Walton, Wenqing He
Parkinson's disease (PD) is a neurodegenerative disorder that affects fitness to drive. Research that has examined clinical predictors of fitness to drive in PD, using the on-road assessment as the gold standard, has generally used a dichotomous pass/fail decision. However, on-road assessments may also result in one of two additional outcomes (pass with recommendations, or fail-remediable). Individuals within these subgroups may benefit from interventions to improve their fitness to drive abilities. This study investigated clinical predictors that could be indicative of the pass, pass with recommendations, or fail-remediable categories for drivers with PD (N = 99)...
October 2015: OTJR: Occupation, Participation and Health
https://www.readbyqxmd.com/read/27460631/developmental-exposure-to-paraquat-and-maneb-can-impair-cognition-learning-and-memory-in-sprague-dawley-rats
#14
Bai Li, Xi He, Yan Sun, Baixiang Li
Paraquat and maneb are identified environmental pollutants. Combined exposure to paraquat and maneb is a latent risk factor for many diseases, particularly those of the central nervous system, including Parkinson's disease and Alzheimer's disease. Hippocampus is the key structure in memory formation and babies are more sensitive to environmental stimuli than adults, so we investigated the neurotoxicity of paraquat and maneb on the hippocampi of rat pups. Female and male Sprague-Dawley rats were mated (female : male = 2 : 1) every night for a week...
October 20, 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/27458821/glial-na-dependent-ion-transporters-in-pathophysiological-conditions
#15
REVIEW
Francesca Boscia, Gulnaz Begum, Giuseppe Pignataro, Rossana Sirabella, Ornella Cuomo, Antonella Casamassa, Dandan Sun, Lucio Annunziato
Sodium dynamics are essential for regulating functional processes in glial cells. Indeed, glial Na(+) signaling influences and regulates important glial activities, and plays a role in neuron-glia interaction under physiological conditions or in response to injury of the central nervous system (CNS). Emerging studies indicate that Na(+) pumps and Na(+) -dependent ion transporters in astrocytes, microglia, and oligodendrocytes regulate Na(+) homeostasis and play a fundamental role in modulating glial activities in neurological diseases...
October 2016: Glia
https://www.readbyqxmd.com/read/27444842/sex-differences-in-the-clinical-progression-of-parkinson-s-disease
#16
Nabila Dahodwala, Qinglin Pei, Peter Schmidt
OBJECTIVE: To describe characteristics of Parkinson's disease by sex and determine if differences in disease progression exist. DESIGN: Longitudinal, observational study. SETTING: Twenty-one National Parkinson Foundation Centers of Excellence. PARTICIPANTS: People (N = 4,679; 63% men and 37% women) with idiopathic Parkinson's disease. METHODS: Demographic and clinical data at enrollment and after 1 year were collected...
September 2016: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/27368068/transmission-of-neurodegenerative-disorders-through-blood-transfusion-a-cohort-study
#17
Gustaf Edgren, Henrik Hjalgrim, Klaus Rostgaard, Paul Lambert, Agneta Wikman, Rut Norda, Kjell-Einar Titlestad, Christian Erikstrup, Henrik Ullum, Mads Melbye, Michael P Busch, Olof Nyrén
BACKGROUND: The aggregation of misfolded proteins in the brain occurs in several neurodegenerative disorders. Aberrant protein aggregation is inducible in rodents and primates by intracerebral inoculation. Possible transfusion transmission of neurodegenerative diseases has important public health implications. OBJECTIVE: To investigate possible transfusion transmission of neurodegenerative disorders. DESIGN: Retrospective cohort study. SETTING: Nationwide registers of transfusions in Sweden and Denmark...
September 6, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27343168/differentiation-and-characterization-of-dopaminergic-neurons-from-baboon-induced-pluripotent-stem-cells
#18
Douglas A Grow, DeNard V Simmons, Jorge A Gomez, Matthew J Wanat, John R McCarrey, Carlos A Paladini, Christopher S Navara
UNLABELLED: : The progressive death of dopamine producing neurons in the substantia nigra pars compacta is the principal cause of symptoms of Parkinson's disease (PD). Stem cells have potential therapeutic use in replacing these cells and restoring function. To facilitate development of this approach, we sought to establish a preclinical model based on a large nonhuman primate for testing the efficacy and safety of stem cell-based transplantation. To this end, we differentiated baboon fibroblast-derived induced pluripotent stem cells (biPSCs) into dopaminergic neurons with the application of specific morphogens and growth factors...
September 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27331078/associations-and-implications-of-low-health-literacy-in-parkinson-s-disease
#19
Jori E Fleisher, Krunal Shah, Whitney Fitts, Nabila A Dahodwala
BACKGROUND: Low health literacy (HL) indicates a limited ability to understand and use basic information to make appropriate healthcare decisions. While low HL is associated with higher morbidity, mortality, and healthcare costs in multiple chronic conditions, little is known about HL and its associations in Parkinson's disease (PD). METHODS: Cross-sectional study of non-demented adults with PD participating in the National Parkinson Foundation Parkinson's Outcomes Project at the University of Pennsylvania...
May 2016: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/27239558/fatigue-in-parkinson-s-disease-report-from-a-mutidisciplinary-symposium
#20
Joseph H Friedman, James C Beck, Kelvin L Chou, Gracia Clark, Christopher P Fagundes, Christopher G Goetz, Karen Herlofson, Benzi Kluger, Lauren B Krupp, Anthony E Lang, Jao-Shin Lou, Laura Marsh, Anne Newbould, Daniel Weintraub
Fatigue is a severe problem for many people living with Parkinson's disease (PD). Best estimates suggest that more than 50% of patients experience this debilitating symptom. Little is known about its etiology or treatment, making the understanding of fatigue a true unmet need. As part of the Parkinson's Disease Foundation Community Choice Research Program, patients, caregivers, and scientists attended a symposium on fatigue on 16 and 17 October 2014. We present a summary of that meeting, reviewing what is known about the diagnosis and treatment of fatigue, its physiology, and what we might learn from multiple sclerosis (MS), depression, and cancer-disorders in which fatigue figures prominently too...
2016: NPJ Parkinsons Dis
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