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Essential Tremor Foundation

Vibhor Krishna, Francesco Sammartino, Ali Rezai
Importance: Magnetic resonance imaging-guided focused ultrasound ablation has been approved for the treatment of refractory essential tremor and is being studied for other neurological indications, including dyskinesias and tremor in Parkinson disease, dystonia, neuropathic pain, obsessive-compulsive disorder, epilepsy, and brain tumors. Objective: To review the scientific foundations of FUS technology, existing neurological applications, and future advances. Evidence Review: PubMed was searched for the past 10 years using the terms "transcranial ultrasound," "focused ultrasound," and "neurological applications...
February 1, 2018: JAMA Neurology
David J Aum, Travis S Tierney
Deep brain stimulation (DBS) has emerged as a revolutionary treatment option for essential tremor (ET), Parkinson's disease (PD), idiopathic dystonia, and severe obsessive-compulsive disorder (OCD). This article reviews the historical foundations of DBS including basal ganglia pathophysiological models, classic principles of electrical stimulation, technical components of the DBS system, treatment risks, and future directions for DBS. Chronic high frequency stimulation induces a number of functional changes from fast physiological to slower metabolic effects and ultimately leads to structural reorganization of the brain, so-called neuroplasticity...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
F Hopfner, G Deuschl
Essential tremor (ET) is a frequent movement disorder. The new tremor classification has subdivided ET into the classical form with bilateral action tremor of the hands with or without involvement of further tremor locations and without any other explaining signs or symptoms for the tremor and into 'ET plus' which comes additionally with further neurological signs of unknown origin. This will provide a better foundation for subclassifying the condition. The immediate cause of ET is a preformed oscillating network within the central nervous system as revealed with electrophysiological methods...
January 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Eran Klein, Tim Brown, Matthew Sample, Anjali R Truitt, Sara Goering
Neural devices now under development stand to interact with and alter the human brain in ways that may challenge standard notions of identity, normality, authority, responsibility, privacy and justice.
November 2015: Hastings Center Report
Elan D Louis, Brittany Rohl, Catherine Rice
BACKGROUND: Patient-centeredness (i.e., providing care that is responsive to individual patient preferences) is increasingly recognized as a crucial element of quality of care. METHODS: A six-item patient-centeredness questionnaire was devised to assess the self-perceived needs of essential tremor (ET) patients. A link to the questionnaire was included in the monthly e-newsletter of the International Essential Tremor Foundation. The questionnaires were completed online and data were available in electronic format...
2015: Tremor and Other Hyperkinetic Movements
Sophie J Holding, Adina R Lew
Research with community- and clinic-based samples of essential tremor (ET) sufferers has identified embarrassment as a common consequence of the condition, leading to social anxiety and avoidance. We sought to ascertain whether psychological avoidance was related to embarrassment in ET, and whether any such relation was independent of symptom severity. Establishing whether psychological avoidance is related to embarrassment in ET would be a first indicator that mindfulness-based therapeutic approaches may be appropriate for sufferers of ET...
March 2015: Chronic Illness
W Jeffrey Elias, Diane Huss, Tiffini Voss, Johanna Loomba, Mohamad Khaled, Eyal Zadicario, Robert C Frysinger, Scott A Sperling, Scott Wylie, Stephen J Monteith, Jason Druzgal, Binit B Shah, Madaline Harrison, Max Wintermark
BACKGROUND: Recent advances have enabled delivery of high-intensity focused ultrasound through the intact human cranium with magnetic resonance imaging (MRI) guidance. This preliminary study investigates the use of transcranial MRI-guided focused ultrasound thalamotomy for the treatment of essential tremor. METHODS: From February 2011 through December 2011, in an open-label, uncontrolled study, we used transcranial MRI-guided focused ultrasound to target the unilateral ventral intermediate nucleus of the thalamus in 15 patients with severe, medication-refractory essential tremor...
August 15, 2013: New England Journal of Medicine
Nir Lipsman, Michael L Schwartz, Yuexi Huang, Liesly Lee, Tejas Sankar, Martin Chapman, Kullervo Hynynen, Andres M Lozano
BACKGROUND: Essential tremor is the most common movement disorder and is often refractory to medical treatment. Surgical therapies, using lesioning and deep brain stimulation in the thalamus, have been used to treat essential tremor that is disabling and resistant to medication. Although often effective, these treatments have risks associated with an open neurosurgical procedure. MR-guided focused ultrasound has been developed as a non-invasive means of generating precisely placed focal lesions...
May 2013: Lancet Neurology
Elan D Louis
Essential tremor (ET) is one of the most common neurological disorders. In recent years, as a result of systematic post-mortem examinations, our knowledge of the pathophysiology of this disease has grown substantially. Clearly identifiable structural changes (ie, Purkinje cell loss, Lewy bodies) have been observed in the brains of individuals with ET. These changes are not uniform and seem to follow several patterns, localising to the cerebellum itself or to a collection of brainstem neurons that synapse directly with Purkinje cells...
June 2010: Lancet Neurology
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2000: Neurology
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