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https://www.readbyqxmd.com/read/28734225/adverse-effects-of-methylmercury-mehg-on-life-parameters-antioxidant-systems-and-mapk-signaling-pathways-in-the-rotifer-brachionus-koreanus-and-the-copepod-paracyclopina-nana
#1
Young Hwan Lee, Duck-Hyun Kim, Hye-Min Kang, Minghua Wang, Chang-Bum Jeong, Jae-Seong Lee
To evaluate the adverse effects of MeHg on the rotifer Brachionus koreanus and the copepod Paracyclopina nana, we assessed the effects of MeHg toxicity on life parameters (e.g. growth retardation and fecundity), antioxidant systems, and mitogen-activated protein kinase (MAPK) signaling pathways at various concentrations (1ng/L, 10ng/L, 100ng/L, 500ng/L, and 1000ng/L). MeHg exposure resulted in the growth retardation with the increased ROS levels but decreased glutathione (GSH) levels in a dose-dependent manner in both B...
July 12, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28732439/the-extract-of-portulaca-oleracea-and-its-constituent-alpha-linolenic-acid-affects-serum-oxidant-levels-and-inflammatory-cells-in-sensitized-rats
#2
Mahsa Kaveh, Akram Eidi, Ali Nemati, Mohammad Hossein Boskabady
The effects of Portulaca oleracea and its constituent, alpha linolenic acid on serum oxidant levels and inflammatory cells in sensitized rats were examined. Eight groups of rats including control, sensitized, sensitized rats treated with 1, 2 and 4 mg/mL extract of P. oleracea, 0.2 and 0.4 mg/mL alpha linolenic acid (ALA) and 1.25 μg/mL dexamethaswere studied serum levels of superoxide dismutase (SOD), catalase (CAT, thiol groups, NO2, NO3, and Malondialdehyde (MDA) as well as total and differential WBC in blood were measured...
June 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28730560/impairment-of-ntca-gene-revealed-its-role-in-regulating-iron-homeostasis-ros-production-and-cellular-phenotype-under-iron-deficiency-in-cyanobacterium-anabaena-sp-pcc-7120
#3
Manish Singh Kaushik, Meenakshi Srivastava, Anumeha Singh, Arun Kumar Mishra
Iron deficiency ends up into several unavoidable consequences including damaging oxidative stress in cyanobacteria. NtcA is a global nitrogen regulator controls wide range of metabolisms in addition to regulation of nitrogen metabolism. In present communication, NtcA based regulation of iron homeostasis, ROS production and cellular phenotype under iron deficiency in Anabaena 7120 has been investigated. NtcA regulates the concentration dependent iron uptake by controlling the expression of furA gene. NtcA also regulated pigment synthesis and phenotypic alterations in Anabaena 7120...
August 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28730524/genetic-characterization-of-novel-reassortant-h5n6-subtype-influenza-viruses-isolated-from-cats-in-eastern-china
#4
Xueliang Cao, Fan Yang, Haibo Wu, Lihua Xu
Cats are susceptible to influenza A viruses and therefore may act as transmission vectors within households, posing a potential public health concern. Two novel reassortant H5N6 influenza viruses were isolated from cats in Zhejiang Province, Eastern China, in 2016. Both viruses were characterized by whole-genome sequencing with subsequent phylogenetic analysis and genetic comparison. Phylogenetic analysis showed that these viruses received their genes from H5N6, H9N2, and H7N9 influenza viruses isolated from China...
July 21, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28728048/accumulation-and-detoxification-dynamics-of-chromium-and-antioxidant-responses-in-juvenile-rare-minnow-gobiocypris-rarus
#5
Cong Yuan, Meng Li, Yao Zheng, Ying Zhou, Feili Wu, Zaizhao Wang
Hexavalent chromium (Cr(6+)) compounds are hazardous via all exposure routes. To explore the dynamics of Cr accumulation and elimination and to reveal the mechanisms underlying detoxification and antioxidation in juvenile Gobiocypris rarus, one-month old G. rarus larvae were exposed to 0.1mgL(-1) Cr(6+) for four weeks for accumulation and subsequently placed to clean water for another week for depuration. The contents of Cr were measured weekly in the whole body of G. rarus juveniles. The activities of catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST) and glutathione reductase (GR), and contents of glutathione (GSH) and malonaldehyde (MDA), and transcripts of cat, Cu/Zn-sod, Mn-sod, gpx1, gstpi, gr, mt1, nrf2 and uba52 were determined...
July 11, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28727420/bio-inspired-development-of-p-st-maa-avermectins-nanoparticles-with-high-affinity-for-foliage-to-enhance-folia-retention
#6
Jie Liang, Manli Yu, Liya Guo, Bo Cui, Xiang Zhao, Changjiao Sun, Yan Wang, Guoqiang Liu, Haixin Cui, Zhanghua Zeng
Pesticides are chemical or biological substances to control pests and protect crop yield. Most pesticides suffering from large amounts of losses in the environment, lead to damage of ecological systems and food pollution. To reduce their losses and increase utilization rate, we have developed a bio-inspired by mussel avermectins nanoparticles (P(St-MAA)-Av-Cat) with strong adhesion to crop foliage by emulsion-solvent evaporation method and chemical modification. They were near spheres sharpness with a diameter around 120 nm...
July 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28726715/overexpression-of-the-osimp-gene-increases-the-accumulation-of-inositol-and-confers-enhanced-cold-tolerance-in-tobacco-through-modulation-of-the-antioxidant-enzymes-activities
#7
Rong-Xiang Zhang, Li-Jun Qin, De-Gang Zhao
Inositol is a cyclic polyol that is involved in various physiological processes, including signal transduction and stress adaptation in plants. l-myo-inositol monophosphatase (IMPase) is one of the metal-dependent phosphatase family members and catalyzes the last reaction step of biosynthesis of inositol. Although increased IMPase activity induced by abiotic stress has been reported in chickpea plants, the role and regulation of the IMP gene in rice (Oryza sativa L.) remains poorly understood. In the present work, we obtained a full-length cDNA sequence coding IMPase in the cold tolerant rice landraces in Gaogonggui, which is named as OsIMP...
July 20, 2017: Genes
https://www.readbyqxmd.com/read/28726228/microwave-irradiation-and-citric-acid-assisted-seed-germination-and-phytoextraction-of-nickel-ni-by-brassica-napus-l-morpho-physiological-and-biochemical-alterations-under-ni-stress
#8
Mujahid Farid, Shafaqat Ali, Muhammad Rizwan, Rashid Saeed, Hafiz Muhammad Tauqeer, Rasham Sallah-Ud-Din, Ahmed Azam, Nighat Raza
The complex bio-geochemistry of soil allows pollutant to persist for a longer period of time which further decreased the fertility and natural composition of land. Nickel, an inorganic pollutant, coming from a wide range of industrial and manufacturing units possesses serious threat to soil degradation and crop productivity around the world. The present study was carried to evaluate the combined role of microwave irradiation (MR) and citric acid (CA) on the phytoextraction potential of Brassica napus L. under Ni stress...
July 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28724908/design-and-discovery-of-novel-monastrol-1-3-5-triazines-as-potent-anti-breast-cancer-agent-via-attenuating-epidermal-growth-factor-receptor-tyrosine-kinase
#9
Jitendra Kumar Srivastava, Girinath G Pillai, Hans Raj Bhat, Amita Verma, Udaya Pratap Singh
A novel series of hybrid analogues of monastrol-1,3,5-triazine were designed and developed via one-pot synthesis using Bi(NO3)3 as a catalyst. Entire compounds were evaluated for their anticancer activity against HeLa (cervical cancer), MCF-7 (breast cancer), HL-60 (Human promyelocytic leukemia), HepG2 (Hepatocellular carcinoma) and MCF 12A (normal epithelial breast cell line) using MTT assay, where they showed highest inhibitory activity against MCF-7. The molecules were also found to be non-toxic to MCF 12A cells...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724438/synergy-between-dinotefuran-and-fipronil-against-the-cat-flea-ctenocephalides-felis-improved-onset-of-action-and-residual-speed-of-kill-in-adult-cats
#10
Romain Delcombel, Hamadi Karembe, Bakela Nare, Audrey Burton, Julian Liebenberg, Josephus Fourie, Marie Varloud
BACKGROUND: The cat flea, Ctenocephalides felis felis (C. felis), is a cosmopolitan hematophagous ectoparasite, and is considered to be the most prevalent flea species in both Europe and the USA. Clinical signs frequently associated with flea bites include pruritus, dermatitis and in severe cases even pyodermatitis and alopecia. Ctenocephalides felis is also a vector for several pathogens and is an intermediate host for the cestode Dipylidium caninum. Treatment of cats with a fast-acting pulicide, that is persistently effective in protecting the animal against re-infestation, is therefore imperative to their health...
July 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28722222/catalase2-functions-for-seedling-post-germinative-growth-by-scavenging-h2-o2-and-stimulating-acx2-3-activity-in-arabidopsis
#11
Wen-Cheng Liu, Tong-Tong Han, Hong-Mei Yuan, Zhen-Dong Yu, Lin-Yu Zhang, Bing-Lei Zhang, Shuang Zhai, Si-Qiu Zheng, Ying-Tang Lu
Increased fatty acid β-oxidation is essential for early post-germinative growth in seedlings, but high levels of H2 O2 produced by β-oxidation can induce oxidative stress. Whether and how catalase (CAT) functions in fine-tuning H2 O2 homeostasis during seedling growth remain unclear. Here, we report that CAT2 functions in early seedling growth. Compared to the wild type, the cat2-1 mutant, with elevated H2 O2 levels, exhibited reduced root elongation on sucrose (Suc)-free medium, mimicking soils without exogenous sugar supply...
July 19, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28721559/anatomical-specificity-of-the-brain-in-the-modulation-of-neuroglobin-and-cytoglobin-genes-after-chronic-bisphenol-a-exposure
#12
Rodrigo Rodrigues da Conceição, Janaina Sena de Souza, Kelen Carneiro de Oliveira, Rui Monteiro de Barros Maciel, Marco Aurélio Romano, Renata Marino Romano, Magnus Régios Dias da Silva, Maria Izabel Chiamorela, Gisele Giannocco
The aim of this study was to investigate the influence of Bisphenol A (BPA) exposure on Neuroglobin (Ngb) and Cytoglobin (Cygb) as well as oxidative stress gene expression in the cerebellum, hippocampus, hypothalamus and cortex. Male Wistar rats were randomly divided into 3 groups: Control and two groups receiving 2 different daily BPA dosages, 5 or 25 mg/kg from postnatal day 50 (PND50) through PND90 and they were euthanized at PND105. In the cortex, we found an increase in Ngb gene expression and also in superoxide dismutase 1 and Catalase (Cat)...
July 18, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28721486/modulatory-effect-of-lycopene-against-carbofuran-toxicity-in-african-catfish-clarias-gariepinus
#13
Heba S Hamed, Alaa G M Osman
In the current study, African catfish, Clarias gariepinus, was exposed to a sublethal concentration of carbofuran (CF) to investigate its negative effects on biochemical and oxidative stress biomarkers. Also, the putative role of lycopene (LYC) administration in alleviating these negative effects was evaluated. Fish were divided into six groups in triplicates as follows: group I was without treatment, group II was orally administered corn oil, group III was orally administered 18 mg LYC/kg body weight, group IV was exposed to 0...
July 18, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28721054/neuroprotective-effects-of-curdione-against-focal-cerebral-ischemia-reperfusion-injury-in-rats
#14
Xing-Jie Li, Li Liang, Hong-Xia Shi, Xiao-Ping Sun, Jing Wang, Lian-Sheng Zhang
BACKGROUND: Curdione is one of the most highly concentrated component of the active constituents in E-zhu, which has been reported to possess a variety of activities. However, the pharmacologic neuroprotective activity of curdione has not been evaluated. The present study aimed to investigate the protective effect of curdione on focal cerebral ischemia reperfusion-induced injury in rats and further exploring the underlying mechanisms. MATERIALS AND METHODS: Adult male Sprague Dawley rats were subjected to middle cerebral artery occlusion (MCAO) surgery for 2 h, followed by reperfusion stage...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28720385/differences-of-lipid-membrane-modulation-and-oxidative-stress-by-digoxin-and-21-benzylidene-digoxin
#15
Lilian Nd Silva, Silmara Lg Alves, Jessica Venugopal, Vanessa F Cortes, Herica L Santos, José Afp Villar, Leandro A Barbosa
Cardiotonic steroids (CTS) are compounds which bind to the Na,K-ATPase, leading to its inhibition and in some cases initiating signaling cascades. Long utilized as a treatment for congestive heart disease, CTS have more recently been observed to inhibit proliferation and cause apoptosis in several cancer cell lines. A synthetic derivative of the CTS digoxin, called 21-benzylidene digoxin (21-BD), activates the Na,K-ATPase rather than cause its inhibition, as its parent compound does. Here, the mechanism behind the unique effects of 21-BD are further explored...
July 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28720336/baseline-symptom-score-impact-on-benefits-of-glycopyrrolate-formoterol-mdi-in-copd
#16
Fernando J Martinez, Leonardo M Fabbri, Gary T Ferguson, Chad Orevillo, Patrick Darken, Ubaldo J Martin, Colin Reisner
BACKGROUND: Chronic obstructive pulmonary disease (COPD) clinical severity is presently categorized by symptom burden and exacerbation risk. Previous 24-week Phase III trials (NCT01854645 and NCT01854658) that demonstrated better improvement of lung function with GFF MDI, a metered dose inhaler fixed-dose combination of glycopyrrolate/formoterol fumarate 18/9.6 μg, over individual monocomponent MDIs included a cross-section of patients with moderate-to-very severe airflow limitation and a broad range of COPD symptoms...
July 15, 2017: Chest
https://www.readbyqxmd.com/read/28720302/clinical-reasoning-in-feline-epilepsy-which-combination-of-clinical-information-is-useful
#17
Gabriela-Dumitrita Stanciu, Rowena Mary Anne Packer, Akos Pakozdy, Gheorghe Solcan, Holger Andreas Volk
We sought to identify the association between clinical risk factors and the diagnosis of idiopathic epilepsy (IE) or structural epilepsy (SE) in cats, using statistical models to identify combinations of discrete parameters from the patient signalment, history and neurological examination findings that could suggest the most likely diagnosis. Data for 138 cats with recurrent seizures were reviewed, of which 110 were valid for inclusion. Seizure aetiology was classified as IE in 57% and SE in 43% of cats. Binomial logistic regression analyses demonstrated that pedigree status, older age at seizure onset (particularly >7years old), abnormal neurological examinations, and ictal vocalisation were associated with a diagnosis of SE compared to IE, and that ictal salivation was more likely to be associated with a diagnosis of IE than SE...
July 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28720299/cats-with-diabetes-mellitus-have-diastolic-dysfunction-in-the-absence-of-structural-heart-disease
#18
N J Pereira, J Novo Matos, M Baron Toaldo, U Bartoszuk, N Summerfield, A Riederer, C Reusch, T M Glaus
Diabetes mellitus (DM) can result in cardiovascular dysfunction and heart failure characterized by diastolic dysfunction with or without the presence of systolic dysfunction in people and laboratory animals. The objective of this prospective study was to determine if cats with newly diagnosed DM had myocardial dysfunction and, if present, whether it would progress if appropriate antidiabetic therapy was commenced. Thirty-two diabetic cats were enrolled and received baseline echocardiographic examination; of these, 15 cats were re-examined after 6 months...
July 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28720294/papillomaviruses-in-dogs-and-cats
#19
REVIEW
John S Munday, Neroli A Thomson, Jennifer A Luff
Papillomaviruses (PVs) cause disease in both dogs and cats. In dogs, PVs are thought to cause oral papillomatosis, cutaneous papillomas and canine viral pigmented plaques, whereas PVs have been rarely associated with the development of oral and cutaneous squamous cell carcinomas in this species. In cats, PVs are currently thought to cause oral papillomas, feline viral plaques, Bowenoid in situ carcinomas and feline sarcoids. Furthermore, there is increasing evidence that PVs may also be a cause of cutaneous squamous cell carcinomas and basal cell carcinomas in cats...
July 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28719953/new-definitive-hosts-and-differential-body-indices-of-isthmiophora-hortensis-digenea-echinostomatidae
#20
Woon-Mok Sohn, Byoung-Kuk Na, Sung-Shik Shin
The present study was performed to record new definitive hosts of Isthmiophora hortensis, and to describe morphological characteristics derived from a variety of worm samples for clarification of its taxonomic validity. Morphological characteristics with dimensions were observed in worm samples (n=21) from naturally infected wild animals, including a raccoon dog Nyctereutes procyonoides from Gimhae-si (City), Gyeongsangnam-do, stray cats and a striped field mouse from several localities, and a wild boar Sus scrofa, from Gurye-gun (County), Jeollanam-do...
June 2017: Korean Journal of Parasitology
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