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https://www.readbyqxmd.com/read/28427087/pretreatment-serum-uracil-concentration-as-a-predictor-of-severe-and-fatal-fluoropyrimidine-associated-toxicity
#1
Didier Meulendijks, Linda M Henricks, Bart A W Jacobs, Abidin Aliev, Maarten J Deenen, Niels de Vries, Hilde Rosing, Erik van Werkhoven, Anthonius de Boer, Jos H Beijnen, Caroline M P W Mandigers, Marcel Soesan, Annemieke Cats, Jan H M Schellens
BACKGROUND: We investigated the predictive value of dihydropyrimidine dehydrogenase (DPD) phenotype, measured as pretreatment serum uracil and dihydrouracil concentrations, for severe as well as fatal fluoropyrimidine-associated toxicity in 550 patients treated previously with fluoropyrimidines during a prospective multicenter study. METHODS: Pretreatment serum concentrations of uracil and dihydrouracil were measured using a validated LC-MS/MS method. The primary endpoint of this analysis was global (any) severe fluoropyrimidine-associated toxicity, that is, grade ⩾3 toxicity according to the NCI CTC-AE v3...
April 20, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28426412/fatal-aelurostrongylosis-in-a-kitten-in-serbia
#2
Pavle Gavrilović, Milijan Jovanović, Aleksandra Gavrilović, Slađan Nešić
This paper describes a case of aelurostrongylosis in a four-month old female domestic cat (Felis catus) from South Banat, Serbia. The kitten that had died suddenly without signs of illness was autopsied in the Veterinary Specialised Institute "Pančevo". The macroscopic finding was typical of granulomatous pneumonia and subsequently, histopathology revealed verminous pneumonia. Based on the parasite morphology, it was confirmed that the lung lesions were caused by Aelurostrongylus abstrusus. The present finding contributes to the knowledge of the prevalence of this underestimated parasite in the Balkan Peninsula...
June 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28426287/pregnancy-and-the-acceptability-of-computer-based-versus-traditional-mental-health-treatments
#3
Liisa Hantsoo, Jessica Podcasy, Mary Sammel, Cynthia Neill Epperson, Deborah R Kim
BACKGROUND: Recent recommendations urge increased depression screening in pregnant and postpartum women, potentially increasing demand for treatment. Computer-based psychotherapy treatments may address some of perinatal women's unique mental health treatment needs and barriers. MATERIALS AND METHODS: We conducted a quantitative survey of pregnant women (≥12 weeks of gestation) on preferences regarding computer-based therapies compared with traditional therapies (psychotherapy and medication)...
April 20, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28426073/ameliorative-effects-of-pepsin-digested-chicken-liver-hydrolysates-on-development-of-alcoholic-fatty-livers-in-mice
#4
Yi-Ling Lin, Szu-Yun Tai, Jr-Wei Chen, Chung-Hsi Chou, Shih-Guei Fu, Yi-Chen Chen
With developments in economics and increasing work loads, alcohol abuse becomes more and more severe, leading to occurrences of alcoholic liver disease (ALD). Pepsin-digested chicken liver hydrolysates (CLHs) contain high amounts of glutamic acid, leucine, lysine, and alanine while the contents of taurine, anserine, and carnosine are also elevated after pepsin hydrolyzation. The objectives of this study were to evaluate the protective effects of CLHs against chronic alcohol consumption. The results indicated that the enlarged (p < 0...
April 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28425450/toxicological-and-biochemical-basis-of-synergism-between-the-entomopathogenic-fungus-lecanicillium-muscarium-and-the-insecticide-matrine-against-bemisia-tabaci-gennadius
#5
Shaukat Ali, Can Zhang, Zeqing Wang, Xing-Min Wang, Jian-Hui Wu, Andrew G S Cuthbertson, Zhenfang Shao, Bao-Li Qiu
The sweetpotato whitefly Bemisia tabaci (Gennadius) was challenged with different combinations of matrine (insecticide) and Lecanicillium muscarium (entomopathogenic fungus). Our results revealed a synergistic relationship between matrine and L. muscarium on mortality and enzyme activities of B. tabaci. To illustrate the biochemical mechanisms involved in detoxification and immune responses of B. tabaci against both control agents, activities of different detoxifying and antioxidant enzymes were quantified...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28425361/assessment-of-real-time-pcr-cycle-threshold-values-in-microsporum-canis-culture-positive-and-culture-negative-cats-in-an-animal-shelter-a-field-study
#6
Linda S Jacobson, Lauren McIntyre, Jenny Mykusz
Objectives Real-time PCR provides quantitative information, recorded as the cycle threshold (Ct) value, about the number of organisms detected in a diagnostic sample. The Ct value correlates with the number of copies of the target organism in an inversely proportional and exponential relationship. The aim of the study was to determine whether Ct values could be used to distinguish between culture-positive and culture-negative samples. Methods This was a retrospective analysis of Ct values from dermatophyte PCR results in cats with suspicious skin lesions or suspected exposure to dermatophytosis...
April 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28425327/a-cross-sectional-quantitative-rt-pcr-study-of-feline-coronavirus-viremia-and-replication-in-peripheral-blood-of-healthy-shelter-cats-in-southern-california
#7
Eric J Fish, Pedro Paulo Vp Diniz, Yen-Chen Juan, Frank Bossong, Ellen W Collisson, Yvonne Drechsler, Bernhard Kaltenboeck
Objectives The objectives of this study were to determine the prevalence of feline coronavirus (FCoV) viremia, and its replication in peripheral blood using quantitative RT-PCR (qRT-PCR) methodology in a population of 205 healthy shelter cats in Southern California, as well as to assess any possible connection to longitudinal development of feline infectious peritonitis (FIP). Methods The study was performed on buffy-coat samples from EDTA-anticoagulated whole blood samples of 205 healthy shelter cats. From 50 of these cats, fecal samples were also examined...
April 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28425145/prevalence-of-gastroesophageal-reflux-in-cats-during-anesthesia-and-effect-of-omeprazole-on-gastric-ph
#8
R S Garcia, P C Belafsky, A Della Maggiore, J M Osborn, B H Pypendop, T Pierce, V J Walker, A Fulton, S L Marks
BACKGROUND: Gastroesophageal reflux (GER) is poorly characterized in anesthetized cats, but can cause aspiration pneumonia, esophagitis, and esophageal stricture formation. OBJECTIVE: To determine whether pre-anesthetic orally administered omeprazole increases gastric and esophageal pH and increases serum gastrin concentrations in anesthetized cats, and to determine the prevalence of GER using combined multichannel impedance and pH monitoring. ANIMALS: Twenty-seven healthy cats undergoing elective dental procedures...
April 19, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28424576/defensive-vocalizations-and-motor-asymmetry-triggered-by-disinhibition-of-the-periaqueductal-gray-in-non-human-primates
#9
Patrick A Forcelli, Hannah F Waguespack, Ludise Malkova
Rapid and reflexive responses to threats are present across phylogeny. The neural circuitry mediating reflexive defense reactions has been well-characterized in a variety of species, for example, in rodents and cats, the detection of and species-typical response to threats is mediated by a network of structures including the midbrain tectum (deep and intermediate layers of the superior colliculus [DLSC]), periaqueductal gray (PAG), and forebrain structures such as the amygdala and hypothalamus. However, relatively little is known about the functional architecture of defense circuitry in primates...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28424428/global-mirna-expression-profiling-of-domestic-cat-livers-following-acute-toxoplasma-gondii-infection
#10
Wei Cong, Xiao-Xuan Zhang, Jun-Jun He, Fa-Cai Li, Hany M Elsheikha, Xing-Quan Zhu
Although microRNAs (miRNAs) play an important role in liver homeostasis, the extent to which they can be altered by Toxoplasma gondii infection is unknown. Here, we utilized small RNA sequencing and bioinformatic analyses to characterize miRNA expression profiles in the liver of domestic cats at 7 days after oral infection with T. gondii (Type II) strain. A total of 384 miRNAs were identified and 82 were differentially expressed, of which 33 were up-regulated and 49 down-regulated. Also, 5690 predicted host gene targets for the differentially expressed miRNAs were identified using the bioinformatic algorithm miRanda...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28424002/enzyme-linked-immunosorbent-assays-for-coproantigen-detection-of-ancylostoma-caninum-and-toxocara-canis-in-dogs-and-toxocara-cati-in-cats
#11
David A Elsemore, Jinming Geng, Jennifer Cote, Rita Hanna, Araceli Lucio-Forster, Dwight D Bowman
We report the development and field validation of 2 ELISAs for the detection of Ancylostoma caninum or Toxocara canis coproantigens in the feces of dogs with experimental and natural infections, and evidence of cross-reactivity with respective feline counterparts. A. caninum-specific coproantigens were detected in feces of experimentally infected dogs starting at 9 d post-infection (dpi), whereas eggs were not seen until 23 dpi. T. canis-specific coproantigens were detected in 3 of 5 experimentally infected dogs by 31 dpi, and 4 of the 5 animals by 38 dpi...
April 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28423628/benzyl-isothiocyanate-induces-reactive-oxygen-species-initiated-autophagy-and-apoptosis-in-human-prostate-cancer-cells
#12
Ji-Fan Lin, Te-Fu Tsai, Shan-Che Yang, Yi-Chia Lin, Hung-En Chen, Kuang-Yu Chou, Thomas I-Sheng Hwang
Benzyl isothiocyanate (BITC) in cruciferous plants, which are part of the human diet, has been shown to induce apoptosis in various types of cancer. In this study, we show that BITC effectively suppresses the growth of cultured human prostate cancer cells (CRW-22Rv1 and PC3) by causing mitochondrial membrane potential loss, caspase 3/7 activation and DNA fragmentation. Furthermore, BITC induces ROS generation in these cells. The induction of apoptosis by BITC was significantly attenuated in the presence of N-acetylcysteine (NAC) and catalase (CAT), well-studied ROS scavengers...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423344/prolonged-dark-period-modulates-the-oxidative-burst-and-enzymatic-antioxidant-systems-in-the-leaves-of-salicylic-acid-treated-tomato
#13
Péter Poór, Zoltán Takács, Krisztina Bela, Zalán Czékus, Gabriella Szalai, Irma Tari
Salicylic acid (SA) is an important plant growth regulator playing a role in the hypersensitive reaction (HR) and the induction of systemic acquired resistance. Since the SA-mediated signalling pathways and the formation of reactive oxygen species (ROS) are light-dependent, the time- and concentration-specific induction of oxidative stress was investigated in leaves of tomato plants kept under light and dark conditions after treatments with 0.1mM and 1mM SA. The application of exogenous SA induced early superoxide- and H2O2 production in the leaves, which was different in the absence or presence of light and showed time- and concentration-dependent changes...
March 23, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28421601/evaluation-of-the-reliability-of-the-cutaneous-dermatomyositis-disease-area-and-severity-index-cdasi-and-the-cutaneous-assessment-tool-binary-method-cat-bm-in-juvenile-dermatomyositis-among-pediatric-dermatologists-rheumatologists-and-neurologists
#14
J Tiao, R Feng, E M Berger, J F Brandsema, C C Coughlin, N Khan, E A Kichula, M A Lerman, S Lvovich, P J McMahon, L G Rider, A I Rubin, L V Scalzi, D M Smith, A J Taxter, J R Treat, R P Williams, S W Yum, J Okawa, V P Werth
BACKGROUND: The Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI) and Cutaneous Assessment Tool-Binary Method (CAT-BM) have been shown to be reliable and valid outcome measures to assess cutaneous disease in adult dermatomyositis (DM) and juvenile DM (JDM), respectively. OBJECTIVE: This study compared the CDASI and CAT-BM for use by pediatric dermatologists, pediatric rheumatologists, and pediatric neurologists in patients with JDM. METHODS: Five pediatric dermatologists, five pediatric rheumatologists, and five pediatric neurologists each evaluated 14 patients with JDM using the CDASI, CAT-BM, and skin Physician Global Assessment (PGA) scales...
April 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28420580/comparative-pharmacodynamic-analysis-of-imidazoline-compounds-using-rat-model-of-ocular-mydriasis-with-a-test-of-quantitative-structure-activity-relationships
#15
Joanna Raczak-Gutknecht, Antoni Nasal, Teresa Frąckowiak, Anita Kornicka, Franciszek Sączewski, Renata Wawrzyniak, Łukasz Kubik, Roman Kaliszan
Imidazol(in)e derivatives, having the chemical structure similar to clonidine, exert diverse pharmacological activities connected with their interactions with alpha2-adrenergic receptors, e.g. hypotension, bradycardia, sedation as well as antinociceptive, anxiolytic, antiarrhythmic, muscle relaxant and mydriatic effects. The mechanism of pupillary dilation observed after systemic administration of imidazol(in)es to rats, mice and cats depends on the stimulation of postsynaptic alpha2-adrenoceptors within the brain...
April 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28419827/antihyperglycemic-antioxidant-activities-of-tucum%C3%A3-oil-astrocaryum-vulgare-in-alloxan-induced-diabetic-mice-and-identification-of-fatty-acid-profile-by-gas-chromatograph-new-natural-source-to-treat-hyperglycemia
#16
Matheus D Baldissera, Carine F Souza, Thirssa H Grando, Luciana F Cossetin, Michele R Sagrillo, Kátia Nascimento, Aleksandro S da Silva, Alencar K Machado, Ivana B M da Cruz, Lenita M Stefani, Bruna Klein, Roger Wagner, Silvia G Monteiro
The aim of the study was to investigate the effect of the oral administration of tucumã oil (Astrocaryum vulgare) on glucose and insulin levels, oxidative status, and pancreatic genotoxic parameters of alloxan-induced diabetic mice. The animals were divided into four groups (n = 6 each): control/water; control/tucumã oil; diabetic/water; diabetic/tucumã oil treated for 14 days with 5.0 mL kg(-1) via oral gavage. Gas chromatograph characterization demonstrated that oleic/elaidic fatty acid is the most abundant component present in this oil, followed by palmitic and stearic fatty acids...
April 15, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28419560/fibroblast-growth-factor-23-concentration-in-dogs-with-chronic-kidney-disease
#17
L M Harjes, V J Parker, K Dembek, G S Young, L H Giovaninni, M M Kogika, D J Chew, R E Toribio
BACKGROUND: Chronic kidney disease (CKD) is associated with hyperphosphatemia, decreased vitamin D metabolite concentrations, and hyperparathyroidism. This syndrome is known as CKD-mineral bone disorder (CKD-MBD). Recently, it has been shown that an increase in fibroblast growth factor-23 (FGF-23) concentration is an early biomarker of CKD in people. It is an independent risk factor for both progression of renal disease and survival time in humans and cats with CKD. Information about FGF-23 in healthy dogs and those with CKD is lacking...
April 17, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28419511/analysis-of-the-variability-of-food-texture-properties-application-to-the-fracturability-of-dry-pet-food
#18
B Gouriou, Ph Bressolette, Ch Vial
An original Stochastic Finite Element Method (SFEM) is proposed for the texture analysis of food products for which samples cannot be standardized. SFEM is able to distinguish shape and texture variability. As an illustration, the methodology is applied to dry cat food using compression testing. First, a deterministic damage elastic model depending on six mechanical and three size parameters is shown to fit adequately experimental data. Then, Morris screening method is applied to FEM data: this highlights that the variability of compression tests is significantly affected by two mechanical and two size parameters...
April 17, 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28419297/host-pore-forming-protein-complex-neutralizes-the-acidification-of-endocytic-organelles-to-counteract-intracellular-pathogens
#19
Sheng-An Li, Long Liu, Xiao-Long Guo, Yu-Yan Zhang, Yang Xiang, Qi-Quan Wang, Wen-Hui Lee, Yun Zhang
Many intracellular pathogens invade cells via endocytic organelles and have adapted to the drop in pH along the endocytic pathway. However, the strategy by which the host cell counteracts this pathogen adaptation remains unclear. βγ-CAT is an aerolysin-like pore-forming protein and trefoil factor complex in the frog Bombina maxima. We report here that βγ-CAT, as a host-secreted factor with an intrinsic channel-forming property, is the first example of a molecule that actively neutralizes the acidification of endocytic organelles to counteract Listeria monocytogenes infection...
April 17, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28419293/expression-and-enzyme-activity-of-catalase-in-chilo-suppressalis-lepidoptera-crambidae-is-responsive-to-environmental-stresses
#20
Yanhui Lu, Qi Bai, Xusong Zheng, Zhongxian Lu
Catalase (CAT) is an important antioxidant enzyme that protects organisms against oxidative stresses by eliminating hydrogen peroxide. In this study, we cloned and characterized a full-length cDNA of CAT from Chilo suppressalis (CsCAT) and examined the influence of environmental stresses on CsCAT expression and enzyme activity. The cDNA contains a 1659-bp open reading frame encoding a polypeptide of 553 amino acids most closely related (90.14%) to Papilio polytes catalases. The CsCAT was expressed in all developmental stages with the highest expression in the fat body, and the CsCAT enzyme activity closely mirrored its observed mRNA expression patterns...
April 15, 2017: Journal of Economic Entomology
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