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https://www.readbyqxmd.com/read/29778043/investigation-of-interactions-of-comtan-with-human-serum-albumin-by-mathematically-modeled-voltammetric-data-a-study-from-bio-interaction-to-biosensing
#1
Ali R Jalalvand, Sirous Ghobadi, Hector C Goicoechea, Hui-Wen Gu, Esmael Sanchooli
In this work, voltammetric data recorded at a glassy carbon electrode (GCE) were separately used to investigate the interactions of entacapone (Comtan, CAT) with human serum albumin (HSA). Then, an augmented data matrix was constructed by the combination of voltammetric and spectroscopic data and simultaneously analysed by multivariate curve resolution-alternating least squares (MCR-ALS) to obtain more information about CAT-HSA interactions. The absence of rotational ambiguities in results obtained by MCR-ALS was verified with the help of MCR-BANDS and we confirmed that the results were unambiguous and reliable...
May 16, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29778019/phoenix-dactylifera-protects-against-oxidative-stress-and-hepatic-injury-induced-by-paracetamol-intoxication-in-rats
#2
Gamal A Salem, Ahmed Shaban, Hussain A Diab, Wesam A Elsaghayer, Manal D Mjedib, Aomassad M Hnesh, Ravi P Sahu
The current studies were sought to determine effects of antioxidant potential of aqueous and methanolic extracts of Phoenix dactylifera leaves (PLAE and PLME) against the widely-used analgesic paracetamol (PCM) induced hepatotoxicity. Groups of rats were treated with or without PCM (1500 mg/kg), PLAE and PLME (300 mg/kg) and n-acetylcysteine (NAC, 50 mg/kg) followed by assessments of liver function tests, oxidative stress, antioxidant defenses, and hepatotoxicity. We observed that PCM significantly elevated serum liver markers, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), and bilirubin compared to control (untreated) group...
May 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29777754/hmgb1-neutralization-attenuates-hippocampal-neuronal-death-and-cognitive-impairment-in-rats-with-chronic-cerebral-hypoperfusion-via-suppressing-inflammatory-responses-and-oxidative-stress
#3
Yue Hei, Rong Chen, Xicai Yi, Qianfa Long, Dakuan Gao, Weiping Liu
High mobility group box-1 (HMGB1) acts as a proinflammatory molecule once released into the extracellular space and inhibition of HMGB1 signaling has been reported be neuroprotective in neurodegenerative diseases. Besides, chronic cerebral hypoperfusion (CCH) causes cognitive impairment in neurodegenerative diseases. Here we tested the protective role of HMGB1 inhibition using anti-HMGB1 neutralizing antibody (Ab) against CCH in rats after bilateral common carotid artery occlusion (2VO). 169 male Sprague-Dawley rats underwent 2VO or sham operation...
May 16, 2018: Neuroscience
https://www.readbyqxmd.com/read/29776838/hot-aqueous-leaf-extract-of-lasianthera-africana-icacinaceae-attenuates-rifampicin-isoniazid-induced-hepatotoxicity
#4
Lucky Legbosi Nwidu, Raphael Ellis Teme
OBJECTIVES: The aim of this study is to evaluate the hepatoprotective effect of Lasianthera africana (Icacinaceae) against isoniazid (INH) and rifampicin (RIF)-induced liver damage in rats. METHODS: The hepatoprotective effects of hot aqueous L. africana (HALA) leaf extract (0.1-1 g/kg) and silymarin (50 mg/kg) were assessed in a model of oxidative liver damage induced by RIF and INH (100 mg/kg each) in Wistar rats for 28 days. Biochemical markers of hepatic damage such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were assessed...
May 8, 2018: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29776613/high-resolution-melting-analysis-hrm-for-the-assessment-of-clonality-in-feline-b-cell-lymphomas
#5
Manfred Henrich, Svenja Scheffold, Werner Hecht, Manfred Reinacher
Analysis of clonality is gaining importance in diagnosing lymphomas in veterinary medicine. Usually, PCR for the analysis of antigen receptor rearrangement (PARR) is followed by electrophoretic separation of the PCR products. Aim of this study was to test the feasibility of HRM for the assessment of clonality in B-cell lymphomas of cats. High resolution melting analysis differentiates PCR products by their different melting point using the decrease in fluorescence of an intercalating dye during melting of the PCR product...
June 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29776599/an-unexpected-finding-of-cat-scratch-colon-in-a-screening-colonoscopy
#6
Natalia Mora Cuadrado, Noelia Alcaide Suárez, Beatriz Antolín Melero, Beatriz Burgueño Gómez, Miguel Durà Gil, Luis Ignacio Fernández Salazar, José Manuel González Hernández
No abstract text is available yet for this article.
May 15, 2018: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/29776315/aerobic-training-reduces-oxidative-stress-in-skeletal-muscle-of-rats-exposed-to-air-pollution-and-supplemented-with-chromium-picolinate
#7
Bruna Marmett, Ramiro Barcos Nunes, Kellen Sábio de Souza, Pedro Dal Lago, Cláudia Ramos Rhoden
OBJECTIVE: The purpose of this study was to investigate the effects of chromium picolinate (CrPic) supplementation associated with aerobic exercise using measures of oxidative stress in rats exposed to air pollution. METHODS: Sixty-one male Wistar rats were divided into eight groups: residual oil fly ash (ROFA) exposure and sedentary (ROFA-SED); ROFA exposure, sedentary and supplemented (ROFA-SED-CrPic); ROFA exposure and trained (ROFA-AT); ROFA exposure, supplemented and trained (ROFA-AT-CrPic); sedentary (Sal-SED); sedentary and supplemented (Sal-SED-CrPic); trained (Sal-AT); and supplemented and trained (Sal-AT-CrPic)...
December 2018: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/29775886/sprint-interval-training-sit-substantially-reduces-depressive-symptoms-in-major-depressive-disorder-mdd-a-randomized-controlled-trial
#8
Alice Minghetti, Oliver Faude, Henner Hanssen, Lukas Zahner, Markus Gerber, Lars Donath
Continuous aerobic exercise training (CAT) is considered a complementary treatment option in patients with major depressive disorder (MDD). Intermittent exercise training protocols, such as sprint interval training (SIT) have gained increasing popularity, but no studies on depressive symptoms following SIT in patients with MDD are available. Fifty-nine in-patients with MDD were randomly assigned to a SIT or CAT group. Medication was counterbalanced in both intervention arms. Both intervention groups received 3 weekly training sessions for 4-weeks (12 sessions in total)...
May 8, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29775243/protective-and-therapeutic-effects-of-dexpanthenol-on-isoproterenol-induced-cardiac-damage-in-rats
#9
Ferhat Kalkan, Hakan Parlakpinar, Olcay M Disli, Lokman H Tanriverdi, Onural Ozhan, Alaaddin Polat, Aslı Cetin, Nigar Vardi, Yılmaz O Otlu, Ahmet Acet
The purpose of the study was to explore the protective and therapeutic effects of dexpanthenol (DEX) on isoproterenol (ISO)-induced cardiac damage. Forty rats were distributed into four groups: group I (Control); group II (ISO); ISO (150 mg/kg/day) was given to rats once a day for 2 consecutive days with an interval of 24 h; group III (DEX+ISO): DEX (250 mg/kg) was applied 30 min before the first ISO administration and continued in the next two days after second ISO administration; group IV (ISO+DEX): After the ISO treatment at 1st and 2nd days, DEX was given at 3rd and 4th days...
May 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29774574/nonsynonymous-single-nucleotide-polymorphisms-in-candidate-genes-p2ry1-p2ry12-and-cyp2c19-for-clopidogrel-efficacy-in-cats
#10
Yu Ueda, Ronald Hak Long Li, Fern Tablin, Eric S Ontiveros, Joshua A Stern
No abstract text is available yet for this article.
May 18, 2018: Animal Genetics
https://www.readbyqxmd.com/read/29773894/corrigendum-early-onset-progressive-retinal-atrophy-associated-with-an-iqcb1-variant-in-african-black-footed-cats-felis-nigripes
#11
Annie Oh, Jacqueline W Pearce, Barbara Gandolfi, Erica K Creighton, William K Suedmeyer, Michael Selig, Ann P Bosiack, Leilani J Castaner, Rebecca E H Whiting, Ellen B Belknap, Leslie A Lyons
This corrects the article DOI: 10.1038/srep43918.
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773684/when-fed-foods-with-similar-palatability-healthy-adult-dogs-and-cats-choose-different-macronutrient-compositions
#12
Jean A Hall, Jodi C Vondran, Melissa A Vanchina, Dennis E Jewell
Dogs and cats make short-term food choices based on palatability. We hypothesized that if palatability were masked, long-term food choices would be based on physiologic requirements, and circulating metabolite concentrations would reflect those choices. Four experimental foods with similar palatability, but varying in macronutrient composition, were prepared for healthy adult dogs (n=17) and cats (n=27). Food 1 was high protein; Food 2 was high fat; Food 3 was high carbohydrates; and Food 4 was balanced for macronutrients...
May 17, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29773294/gastroesophageal-reflux-symptoms-and-nasal-symptoms-affect-the-severity-of-bronchitis-symptoms-in-patients-with-chronic-obstructive-pulmonary-disease
#13
Koichi Hasegawa, Susumu Sato, Kazuya Tanimura, Yoshinori Fuseya, Kiyoshi Uemasu, Yoko Hamakawa, Atsuyasu Sato, Michiaki Mishima, Shigeo Muro, Toyohiro Hirai
BACKGROUND: Cough and sputum production (symptoms of bronchitis) are common in chronic obstructive pulmonary disease (COPD). Extrapulmonary comorbidities, such as gastroesophageal reflux disease (GERD) and post-nasal drip, also cause bronchitis symptoms. The impact of extrapulmonary comorbidities on the severity of bronchitis symptoms in COPD is unknown. The aim of this study was to quantify bronchitis symptoms and assess the impact of GERD and nasal symptoms on the severity of bronchitis symptoms in COPD...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29773293/usefulness-of-the-forced-oscillation-technique-in-assessing-the-therapeutic-result-of-tracheobronchial-central-airway-obstruction
#14
Masanori Yasuo, Yoshiaki Kitaguchi, Fumiya Kinota, Makoto Kosaka, Kazuhisa Urushihata, Atsuhito Ushiki, Hiroshi Yamamoto, Satoshi Kawakami, Masayuki Hanaoka
BACKGROUND: Pulmonary function tests (PFTs) comprise the traditional method for detecting central airway obstruction (CAO) and evaluating therapeutic effects, but are effort-dependent. By contrast, the forced oscillation technique (FOT) is performed during tidal breathing in an effort-independent mode and is universally used to assess respiratory function in patients with chronic obstructive pulmonary disease (COPD) and asthma. We used the FOT to measure airway resistance and reactance in patients with CAO before and after interventional bronchoscopy and compared the results to data obtained using PFTs...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29773188/the-toxic-effect-of-gallic-acid-on-biochemical-factors-viability-and-proliferation-of-rat-bone-marrow-mesenchymal-stem-cells-was-compensated-by-boric-acid
#15
Mohammad Hussein Abnosi, Somayeh Yari
OBJECTIVE: Gallic acid (GA) and boron are found in many plants. Our previous studies showed 6 ng/ml boric acid (BA) had positive effect on biochemistry of rat bone marrow mesenchymal stem cells (MSCs) and their osteogenic differentiation. Therefore, we investigate the effect of different doses of GA alone and in the presence of BA on MSCs. MATERIALS AND METHODS: the viability of MSCs was assayed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and trypan blue at 12, 24 and 36 h in presence of different concentration of GA...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29773140/first-ocular-report-of-gurltia-paralysans-wolffh%C3%A3-gel-1933-in-cat
#16
Raquel Udiz-Rodríguez, Katherine Garcia-Livia, Maria Valladares-Salmerón, Maria Naira Dorta-Almenar, Natalia Martín-Carrillo, Aaron Martin-Alonso, Elena Izquierdo-Rodriguez, Carlos Feliu, Basilio Valladares, Pilar Foronda
A two-year-old cat from Tenerife, Canary Islands (Spain), presented with two months history of uveitis in the left eye. It had been treated for two months but still showed an active uveitis. After new treatment, eye examination showed a mobile worm in the anterior chamber. Following surgical removal, the worm was obtained. Morphological study revealed that it was a male metastrongyloid nematode (Nematoda: Metastrongyloidea) with caudal bursa and two similar spicules. Molecular tools based on the 18Sr RNA gene sequence identified the parasite as Gurltia paralysans, which is a neurotropic nematode previously found in South America...
May 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29772976/effects-of-storage-conditions-and-duration-on-cobalamin-concentration-in-serum-samples-from-cats-and-dogs
#17
Jennifer Kempf, Roger H Melliger, Claudia E Reusch, Peter H Kook
OBJECTIVE To evaluate the effects of storage conditions and duration on cobalamin concentration in serum samples from dogs and cats. DESIGN Experiment. SAMPLE Serum samples from 9 client-owned cats and 9 client-owned dogs. PROCEDURES Serum harvested from freshly obtained blood samples was separated into 11 aliquots/animal. One aliquot (baseline sample) was routinely transported in light-protected tubes to the laboratory for cobalamin assay; each of the remaining aliquots was stored in a refrigerator (6°C; n = 5) or at room temperature (20°C) with exposure to daylight (5) for 24, 48, 72, 96, or 120 hours...
June 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29772965/association-of-surgical-approach-with-complication-rate-progression-free-survival-time-and-disease-specific-survival-time-in-cats-with-mammary-adenocarcinoma-107-cases-1991-2014
#18
Francesco Gemignani, Philipp D Mayhew, Michelle A Giuffrida, Jason Palaigos, Jeffrey J Runge, David E Holt, Nicholas A Robertson, Bernard Seguin, Meaghan Walker, Ameet Singh, Julius M Liptak, Giorgio Romanelli, Marina Martano, Sarah E Boston, Cassie Lux, Roberto Busetto, William T N Culp, Katherine A Skorupski, Jenna H Burton
OBJECTIVE To evaluate potential associations between surgical approach and complication rate, progression-free survival time, and disease-specific survival time in cats with mammary adenocarcinoma. DESIGN Retrospective case series. ANIMALS 107 client-owned cats. PROCEDURES Medical records of cats that underwent surgical excision of mammary adenocarcinoma by means of a unilateral or bilateral (staged or single-session) mastectomy at 9 hospitals between 1991 and 2014 were reviewed. Relevant clinicopathologic data and details of surgical and adjuvant treatments were recorded...
June 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29772964/incidence-of-arterial-catheter-complications-a-retrospective-study-of-35-cats-2010-2014
#19
Shaina Mooshian, Sarah J Deitschel, Jamie M Haggerty, Christine L Guenther
Objectives The aim of this study was to investigate the incidence of complications associated with arterial catheterization in cats in a veterinary hospital, and to document which factors may increase the incidence of complications. Methods Medical records at a referral veterinary hospital were retrospectively reviewed to identify cats that had an arterial catheter placed between January 2010 and October 2014. Results Thirty-five cats having 38 arterial catheters were included in the study. There was a relatively high incidence of minor complications (23...
May 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29772788/application-of-a-protocol-based-on-trap-neuter-return-tnr-to-manage-unowned-urban-cats-on-an-australian-university-campus
#20
Helen Swarbrick, Jacquie Rand
In August 2008, the University of New South Wales (UNSW) in Sydney, Australia, commenced a trap-neuter-return (TNR) program to manage the population of approximately 69 free-roaming unowned urban cats on its Kensington campus. The goals of the program included an ongoing audit of cats on campus, stabilization of cat numbers through TNR, and a subsequent reduction in cat numbers over time while maintaining the health of remaining campus cats. Continuation of the TNR program over nine years resulted in a current population, as of September 2017, of 15 cats, all desexed (78% reduction)...
May 17, 2018: Animals: An Open Access Journal From MDPI
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