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https://www.readbyqxmd.com/read/28540519/progeria-an-extremely-unusual-disorder
#1
Gurnihal Singh Chawla, Purva Mahesh Agrawal, Avinash Dhok
Hutchinson-Gilford progeria syndrome, also known as progeria, is an extremely rare disorder with an incidence rate of 1 in 8 million. It occurs sporadically, and patients suffering from this syndrome usually exhibit premature ageing. It has an autosomal recessive inheritance with a slight male predominance. The affected children usually die early with an average life span of 13.4 years. The most common cause of death in such patients is a cardio-vascular abnormality such as myocardial infarction. We present a rare case of progeria in an 8-year-old boy who was diagnosed clinically and was referred to our department for a skeletal survey...
May 24, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28537802/seasonal-pattern-in-bipolar-disorders-and-cardio-vascular-risk-factors-a-study-from-the-face-bd-cohort
#2
Pierre A Geoffroy, Ophelia Godin, Diane Mahee, Chantal Henry, Valérie Aubin, Jean-Michel Azorin, Thierry Bougerol, Philippe Courtet, Sébastien Gard, Jean-Pierre Kahn, Christine Passerieux, Marion Leboyer, Frank Bellivier, Bruno Etain
Seasonal pattern (SP) and metabolic syndrome (MetS) are major contributors to poor outcome in bipolar disorders (BD). Patients with seasonal bipolar depression present increased appetite, carbohydrate cravings, weight gain, and hypersomnia, which can increase the development of MetS. MetS also appears to be associated with seasonal mood changes in the general population. This study examines whether a SP in BD is associated with an increased risk of MetS and its sub-components. One thousand four hundred and seventy-one outpatients with BD were systematically enrolled from 2009 to 2016...
May 24, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28534121/organic-anion-transporters-oat1-and-oat3-are-crucial-biopterin-transporters-involved-in-bodily-distribution-of-tetrahydrobiopterin-and-exclusion-of-its-excess
#3
Akiko Ohashi, Kaori Mamada, Tomonori Harada, Masako Naito, Tomihisa Takahashi, Shin Aizawa, Hiroyuki Hasegawa
Tetrahydrobiopterin (BH4) is a common coenzyme of phenylalanine-, tyrosine-, and tryptophan hydroxylases, alkylglycerol monooxygenase, and NO synthases (NOS). Synthetic BH4 is used medicinally for BH4-responsive phenylketonuria and inherited BH4 deficiency. BH4 supplementation has also drawn attention as a therapy for various NOS-related cardio-vascular diseases, but its use has met with limited success in decreasing BH2, the oxidized form of BH4. An increase in the BH2/BH4 ratio leads to NOS dysfunction. Previous studies revealed that BH4 supplementation caused a rapid urinary loss of BH4 accompanied by an increase in the blood BH2/BH4 ratio and an involvement of probenecid-sensitive but unknown transporters was strongly suggested in these processes...
May 22, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28489178/blood-pressure-variability-in-the-elderly-association-between-postprandial-and-sleeping-periods
#4
Fernando Abrão Garcia, Beatriz Fidale, Sebastião Rodrigues Ferreira-Filho
Introduction: The variability of arterial blood pressure (BP) is considered an important cardiovascular risk factor. Objective: To verify the possible associations between the postprandial and the sleeping blood pressure variability. Methods: This study evaluated systolic, diastolic, mean, pulse pressures and heart variability in 69 elderly patients in preprandial, postprandial and sleeping periods. One 24 hours ambulatory blood pressure monitoring was used for measurements and the results were showed in the time-rate index...
April 27, 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28455101/sip-1-mutations-cause-disturbances-in-the-activity-of-nmda-and-ampa-but-not-kainate-receptors-of-neurons-in-the-cerebral-cortex
#5
Maria V Turovskaya, Alexei A Babaev, Valery P Zinchenko, Ekaterina A Epifanova, Ekaterina V Borisova, Victor S Tarabykin, Egor A Turovsky
Smad-interacting protein-1 (Sip1) [Zinc finger homeobox (Zfhx1b), Zeb2] is a transcription factor implicated in the genesis of Mowat-Wilson syndrome (MWS) in humans. MWS is a rare genetic autosomal dominant disease caused by a mutation in the Sip1 gene (aka Zeb2 or Zfhx1b) mapped to 2q22.3 locus. MWS affects 1 in every 50-100 newborns worldwide. It is characterized by mental retardation, small stature, typical facial abnormalities as well as disturbances in the development of the cardio-vascular and renal systems as well as some other organs...
April 25, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28432752/incretin-based-glucose-lowering-medications-and-the-risk-of-acute-pancreatitis-and-or-pancreatic-cancer-reassuring-data-from-cardio-vascular-outcome-trials
#6
LETTER
Michael A Nauck, Juris J Meier, Wolfgang E Schmidt
No abstract text is available yet for this article.
April 22, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28411064/health-benefits-of-a-reduction-of-pm10-and-no2-exposure-after-implementing-a-clean-air-plan-in-the-agglomeration-lausanne-morges
#7
Alberto Castro, Nino Künzli, Thomas Götschi
Exposure to urban air pollution has been associated with adverse effects on cardio-vascular and respiratory health, both short and long term. Consequently, governments have applied policies to reduce air pollution. Quantitative health impact assessments of hypothetic changes in air pollution have been conducted at national and global level, but assessments of observed air pollution changes associated with specific clean air policies at a local or regional scale remain scarce. This study estimates health impacts attributable to a decrease in PM10 and NO2 exposure in the Agglomeration of Lausanne-Morges (ALM), Switzerland, between 2005 and 2015, corresponding to the implementation period of a supra-municipal plan of measures to reduce air pollution in different sectors such as transport, energy, and industry (called Plan OPair 05)...
April 5, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28369749/olcegepant-blocks-neurogenic-and-non-neurogenic-cgrpergic-vasodepressor-responses-and-facilitates-noradrenergic-vasopressor-responses-in-pithed-rats
#8
V H Avilés-Rosas, E Rivera-Mancilla, B A Marichal-Cancino, G Manrique-Maldonado, A H Altamirano-Espinoza, A MaassenVanDenBrink, C M Villalón
BACKGROUND AND PURPOSE: Olcegepant (BIBN4096BS) is a selective non-peptide CGRP receptor antagonist with acute antimigraine properties. Since systemic vascular tone is modulated by perivascular (primary sensory CGRPergic and sympathetic) nerves, this randomized study investigated in pithed rats the effect of acute i.v. treatment with olcegepant on the neurogenic and non-neurogenic: (i) CGRPergic vasodepressor responses; and (ii) noradrenergic vasopressor responses. The pithed rat is an experimental model predictive of systemic (cardio) vascular side effects...
March 29, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28352958/the-epigenetic-landscape-of-age-related-diseases-the-geroscience-perspective
#9
Noémie Gensous, Maria Giulia Bacalini, Chiara Pirazzini, Elena Marasco, Cristina Giuliani, Francesco Ravaioli, Giacomo Mengozzi, Claudia Bertarelli, Maria Giustina Palmas, Claudio Franceschi, Paolo Garagnani
In this review, we summarize current knowledge regarding the epigenetics of age-related diseases, focusing on those studies that have described DNA methylation landscape in cardio-vascular diseases, musculoskeletal function and frailty. We stress the importance of adopting the conceptual framework of "geroscience", which starts from the observation that advanced age is the major risk factor for several of these pathologies and aims at identifying the mechanistic links between aging and age-related diseases...
March 28, 2017: Biogerontology
https://www.readbyqxmd.com/read/28337901/cardiopathy-and-osteoporosis-the-epidemiology-in-a-region-of-italy
#10
A Notarnicola, G Maccagnano, L Moretti, S Tafuri, B Moretti
Cardiopathies and osteoporosis are inter-related due to pathogenetic, hormonal, genetic features as well as an increased risk of fragility. An important feature is attributed to the process of atherosclerosis, which is responsible for an osteopenia effect and degeneration of vascular walls. To date the study populations have been limited. To verify the incidence of cardio-vascular disease in a larger osteoporotic population, we designed a retrospective clinical study analyzing the “Hospital Discharge Data” (HDD) in Apulia between 2006 and 2010...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28336130/organizers-and-activators-cytosolic-nox-proteins-impacting-on-vascular-function
#11
REVIEW
Katrin Schröder, Norbert Weissmann, Ralf P Brandes
NADPH oxidases of the Nox family are important enzymatic sources of reactive oxygen species (ROS) in the cardiovascular system. Of the 7 members of the Nox family, at least three depend for their activation on specific cytosolic proteins. These are p47phox and its homologue NoxO1 and p67phox and its homologue NoxA1. Also the Rho-GTPase Rac is important but as this protein has many additional functions, it will not be covered here. The Nox1 enzyme is preferentially activated by the combination of NoxO1 with NoxA1, whereas Nox2 gains highest activity with p47phox together with p67phox...
March 21, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28335768/leisure-sedentary-time-is-differentially-associated-with-hypertension-diabetes-mellitus-and-hyperlipidemia-depending-on-occupation
#12
Man Sup Lim, Bumjung Park, Il Gyu Kong, Songyong Sim, So Young Kim, Jin-Hwan Kim, Hyo Geun Choi
BACKGROUND: Sedentary behavior is considered an independent cause of cardio-metabolic diseases, regardless of physical activity level and obesity. Few studies have reported the association between leisure sedentary time and cardio-vascular diseases in terms of occupation. METHODS: We performed a cross-sectional study using data from the Korean Community Health Survey (KCHS) for 240,086 participants assessed in 2011 and 2013. Occupation was categorized into four groups: farmer or fisherman, laborer, and soldier (Group I); service worker, salesperson, technician, mechanic, production worker, and engineer (Group II); manager, expert, specialist, and clerk (Group III); and unemployed (Group IV)...
March 23, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28303909/sprint-interval-training-induces-a-sexual-dimorphism-but-does-not-improve-peak-bone-mass-in-young-and-healthy-mice
#13
Kathrin Koenen, Isabell Knepper, Madlen Klodt, Anja Osterberg, Ioannis Stratos, Thomas Mittlmeier, Tina Histing, Michael D Menger, Brigitte Vollmar, Sven Bruhn, Brigitte Müller-Hilke
Elevated peak bone mass in early adulthood reduces the risk for osteoporotic fractures at old age. As sports participation has been correlated with elevated peak bone masses, we aimed to establish a training program that would efficiently stimulate bone accrual in healthy young mice. We combined voluntary treadmill running with sprint interval training modalities that were tailored to the individual performance limits and were of either high or intermediate intensity. Adolescent male and female STR/ort mice underwent 8 weeks of training before the hind legs were analyzed for cortical and trabecular bone parameters and biomechanical strength...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28297809/-the-interpretation-of-the-sleep-apnea-cardio-vascular-endpoint-save-study
#14
R Chen, Y M Luo
No abstract text is available yet for this article.
March 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28294880/-results-of-monitoring-of-the-plan-of-measures-directed-to-reduction-of-ischemic-heart-disease-in-north-caucasus-republics-analysis-of-dynamics-of-cardio-vascular-mortality
#15
M N Mamedov
Comparative analysis of dynamics of cardiovascular mortality in Russia and foreign countries as well as main directions of development of cardiological service in Russia are presented in this review article. Plan of measures for reduction of mortality from ischemic heart disease (IHD) was created in 2015. This plan comprises 4 blocks of assessment of the following measures: directed at improvement of primary IHD prevention (1), directed at secondary prevention of complications of IHD (2); directed at improvement of efficacy of medical care of patients with IHD (3), and directed at monitoring of some demographic parameters (4)...
May 2016: Kardiologiia
https://www.readbyqxmd.com/read/28284844/investigating-methotrexate-toxicity-within-a-randomized-double-blinded-placebo-controlled-trial-rationale-and-design-of-the-cardiovascular-inflammation-reduction-trial-adverse-events-cirt-ae-study
#16
Jeffrey A Sparks, Medha Barbhaiya, Elizabeth W Karlson, Susan Y Ritter, Soumya Raychaudhuri, Cassandra C Corrigan, Fengxin Lu, Jacob Selhub, Daniel I Chasman, Nina P Paynter, Paul M Ridker, Daniel H Solomon
BACKGROUND: The role of low dose methotrexate (LDM) in potential serious toxicities remains unclear despite its common use. Prior observational studies investigating LDM toxicity compared LDM to other active drugs. Prior placebo-controlled clinical trials of LDM in inflammatory conditions were not large enough to investigate toxicity. The Cardiovascular Inflammation Reduction Trial (CIRT) is an ongoing NIH-funded, randomized, double-blind, placebo-controlled trial of LDM in the secondary prevention of cardiovascular disease...
February 10, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28256325/cardio-vascular-reserve-index-cvri-during-exercise-complies-with-the-pattern-assumed-by-the-cardiovascular-reserve-hypothesis
#17
Michael J Segel, Ben-Zion Bobrovsky, Itay E Gabbay, Issahar Ben-Dov, Ronen Reuveny, Uri Gabbay
OBJECTIVES: The Cardio-vascular reserve index (CVRI) had been empirically validated in diverse morbidities as a quantitative estimate of the reserve assumed by the cardiovascular reserve hypothesis. This work evaluates whether CVRI during exercise complies with the cardiovascular reserve hypothesis. DESIGN: Retrospective study based on a database of patients who underwent cardio-pulmonary exercise testing (CPX) for diverse indications. METHODS: Patient's physiological measurements were retrieved at four predefined CPX stages (rest, anaerobic threshold, peak exercise and after 2min of recovery)...
May 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28185705/cardiovascular-magnetic-resonance-imaging-pattern-at-the-time-of-diagnosis-of-treatment-na%C3%A3-ve-patients-with-connective-tissue-diseases
#18
Sophie Mavrogeni, George Markousis-Mavrogenis, Loukia Koutsogeorgopoulou, Theodoros Dimitroulas, Konstantinos Bratis, George D Kitas, Petros Sfikakis, Maria Tektonidou, Georgia Karabela, Efthymios Stavropoulos, Gikas Katsifis, Kyriaki A Boki, Anastasia Kitsiou, Vasiliki Filaditaki, Elias Gialafos, Sotiris Plastiras, Vasiliki Vartela, Genovefa Kolovou
BACKGROUND-AIM: Cardiac involvement at diagnosis of connective tissue disease (CTD) has been described by echocardiography. We hypothesized that cardio-vascular magnetic resonance (CMR) detects occult lesions at CTD diagnosis. PATIENTS-METHODS: CMR was performed early after diagnosis in 78 treatment-naïve CTDs (aged 43±11, 59F/19M) without cardiac involvement [5 Takayasu arteritis (TA), 4 Churg Strauss syndrome (CSS), 5 Wegener granulomatosis (WG), 16 systemic lupus erythematosus (SLE), 12 rheumatoid arthritis (RA), 8 mixed connective tissue diseases (MCTD), 12 ankylosing spondylitis (AS), 3 polymyalgia rheumatica (PMR), 8 systemic sclerosis (SSc) and 5 dermatomyositis (DM)]...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28165641/effects-of-nitrate-supplementation-in-trained-and-untrained-muscle-is-modest-with-initial-high-plasma-nitrite-levels
#19
Peter M Christensen, Nanna K Petersen, Signe N Friis, Eddie Weitzberg, Lars Nybo
Nitrate (NO3(-) ) supplementation resulting in higher plasma nitrite (NO2(-) ) is reported to lower resting mean arterial blood pressure (MAP) and oxygen uptake (VO2 ) during submaximal exercise in non-athletic populations, whereas effects in general are absent in endurance trained individuals. To test whether physiological effects of NO3(-) supplementation depend on local muscular training status or cardiovascular fitness, male endurance-trained cyclists (CYC, n=9, VO2 -max: 64±3 ml/min/kg; mean±SD) and recreational active subjects serving as a control group (CON, n=8, 46±3 ml/min/kg), acutely consumed nitrate-rich beetroot-juice ([NO3(-) ] ~9 mmol) (NIT) or placebo (PLA) with assessment of resting MAP and energy expenditure during moderate intensity (~50% VO2 -max) and incremental leg cycling (LEG-ex) and arm cranking exercise (ARM-ex)...
February 6, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28164545/plasma-zonulin-and-its-association-with-kidney-function-severity-of-heart-failure-and-metabolic-inflammation
#20
Thomas B Dschietzig, Felix Boschann, Jana Ruppert, Franz P Armbruster, Andreas Meinitzer, Dragic Bankovic, Veselin Mitrovic, Christoph Melzer
BACKGROUND: The tight junction regulator zonulin has attracted clinical attention as a biomarker of increased gastrointestinal permeability. Recent work also suggests zonulin to represent a general regulator of tissue barriers and a player in metabolic inflammation. Here, we investigated the associations of zonulin with chronic heart failure (CHF), kidney function, and metabolic inflammation. METHODS: Using multiple linear regression (Generalized Linear Model), this study determined the association of plasma zonulin with different laboratory and clinical parameters in 225 patients carrying automatic implantable cardioverters/defibrillators (AICD) for primary or secondary prevention...
December 1, 2016: Clinical Laboratory
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