keyword
https://read.qxmd.com/read/38536934/attenuation-of-fibroblast-activation-and-fibrosis-by-adropin-in-systemic-sclerosis
#1
JOURNAL ARTICLE
Minrui Liang, Nicholas Dickel, Andrea-Hermina Györfi, Bilgesu SafakTümerdem, Yi-Nan Li, Aleix Rius Rigau, Chunguang Liang, Xuezhi Hong, Lichong Shen, Alexandru-Emil Matei, Thuong Trinh-Minh, Cuong Tran-Manh, Xiang Zhou, Ariella Zehender, Alexander Kreuter, Hejian Zou, Georg Schett, Meik Kunz, Jörg H W Distler
Fibrotic diseases impose a major socioeconomic challenge on modern societies and have limited treatment options. Adropin, a peptide hormone encoded by the energy homeostasis-associated ( ENHO ) gene, is implicated in metabolism and vascular homeostasis, but its role in the pathogenesis of fibrosis remains enigmatic. Here, we used machine learning approaches in combination with functional in vitro and in vivo experiments to characterize adropin as a potential regulator involved in fibroblast activation and tissue fibrosis in systemic sclerosis (SSc)...
March 27, 2024: Science Translational Medicine
https://read.qxmd.com/read/38534515/managing-vascular-pedicle-exposure-in-free-tissue-transfer-using-a-reprocessed-micronized-dermal-substitute-in-lower-extremity-reconstructions
#2
JOURNAL ARTICLE
Daheui Kim, Jun Hyeok Lee, Min Suk Park, Ma Rhip Ahn, Daiwon Jun, Jung Ho Lee
Lower extremity reconstruction is challenging because of its intricate anatomy and dynamic biomechanics. Although microsurgical free tissue transfer offers pivotal solutions to limited local tissue availability, vascular pedicle exposure after free tissue transfer is common. We evaluated a novel method of managing pedicle exposure after free tissue transfer using a reprocessed micronized dermal substitute. Ten patients who underwent lower-extremity reconstruction using free tissue transfer and micronized dermal substitute between January and December 2023 were retrospectively reviewed...
February 28, 2024: Bioengineering
https://read.qxmd.com/read/38532200/investigation-of-two-new-grafting-techniques-for-dorsal-augmentation-rhinoplasty-an-experimental-study-with-new-zealand-white-rabbits
#3
JOURNAL ARTICLE
Mehmet Ozdemır, Mehmet Fatih Akkoç, Selcuk Tunık
INTRODUCTION: Cartilage is an important source in supporting the structure of the nose for dorsal augmentation rhinoplasty. However, it is known that its viability is not always on the ideal level. Various wrapping materials are used to increase the strength of cartilage. Donor site morbidity, which develops following the harvesting of both cartilage and fascia as one such cover material, has attracted interest in recent years. OBJECTIVE: In this study, we aimed to investigate the potential of dermis and tendon autografts as alternatives to fascia and cartilage...
March 26, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38529835/biofabrication-strategies-for-oral-soft-tissue-regeneration
#4
REVIEW
Maedeh Rahimnejad, Hardik Makkar, Renan Dal-Fabbro, Jos Malda, Gopu Sriram, Marco C Bottino
Gingival recession, a prevalent condition affecting the gum tissues, is characterized by the exposure of tooth root surfaces due to the displacement of the gingival margin. This review explores conventional treatments, highlighting their limitations and the quest for innovative alternatives. Importantly, it emphasizes the critical considerations in gingival tissue engineering leveraging on cells, biomaterials, and signaling factors. Successful tissue-engineered gingival constructs hinge on strategic choices such as cell sources, scaffold design, mechanical properties, and growth factor delivery...
March 26, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38527839/-evaluation-of-differences-in-quality-of-life-in-patients-with-chronic-graft-versus-host-disease
#5
JOURNAL ARTICLE
S Q Huang, R H Huang, Y Quan, F M Wang, X J Cheng, X Q Wang, X Zhang
Objective: To evaluate the status of, differences in, and factors influencing quality of life (QoL) in patients with chronic graft-versus-host disease (GVHD). Methods: From September 2021 to February 2023, a cross-sectional study of 140 patients with chronic GVHD was conducted at our center. Symptom burden was assessed by the Lee Symptomatology Scale (LSS), and QoL was assessed by the Medical Outcome Study 36-Item Short-Form Health Survey (SF-36) (version 1) and five-level EuroQoL five-dimensional questionnaire (EQ-5D-5L)...
January 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38527348/the-role-of-the-fascia-only-anterolateral-thigh-flap-in-extremity-reconstruction-the-fascia-only-anterolateral-thigh-flap
#6
JOURNAL ARTICLE
Bashar Hassan, Berry Fairchild, Michael P Grant, Gregory A Lamaris
BACKGROUND: Free flap selection in extremity reconstruction can be challenging. The ideal flap has to be thin and pliable to achieve optimal contour and function. We explore the role of the fascia-only anterolateral thigh (fALT) flap in extremity reconstruction. METHODS: We conducted a retrospective review of our experience using fALT-free flap for extremity reconstruction over a 2-year period. Patient demographics, mechanism of injury, flap characteristics, complications- and follow-up were recorded...
April 1, 2024: Annals of Plastic Surgery
https://read.qxmd.com/read/38527318/benefits-of-collaboration-between-the-wound-ostomy-and-continence-nurse-and-orthopedic-surgeon-when-treating-skin-defects-after-soft-tissue-sarcoma-resection-a-retrospective-case-control-study
#7
JOURNAL ARTICLE
Hiromi Sasaki, Tomoyo Nishiobino, Hiroyuki Tominaga, Akihiro Tokushige, Naohiro Shinohara, Satoshi Nagano, Noboru Taniguchi
PURPOSE: The purpose of this study was to evaluate the benefits of collaborative management between orthopedic surgery and WOC nurses in patients undergoing resection of subcutaneous sarcomas. DESIGN: Retrospective case-control study. SUBJECTS AND SETTING: The sample comprised 25 patients who underwent wide resection for soft tissue sarcoma, followed by 2-stage split-thickness skin grafting. Data collection occurred between January 2015 and April 2021 in a university hospital based in Kagoshima, Japan...
March 2024: Journal of Wound, Ostomy, and Continence Nursing
https://read.qxmd.com/read/38526669/preparation-of-xyloglucan-grafted-poly-n-hydroxyethyl-acrylamide-copolymer-by-free-radical-polymerization-for-in-vitro-evaluation-of-human-dermal-fibroblasts
#8
JOURNAL ARTICLE
Maykel González-Torres, Ricardo Martínez-Mata, Erika Karina Ruvalcaba-Paredes, Alicia Del Real, Gerardo Leyva-Gómez, Alfredo Maciel-Cerda
Xyloglucan is a rigid polysaccharide that belongs to the carbohydrate family. This hemicellulose compound has been widely used in biomedical research because of its pseudoplastic, mucoadhesive, mucomimetic, and biocompatibility properties. Xyloglucan is a polyose with no amino groups in its structure, which also limits its range of applications. It is still unknown whether grafting hydrophilic monomers onto xyloglucan can produce derivatives that overcome these shortcomings. This work aimed to prepare the first copolymers in which N-hydroxyethyl acrylamide is grafted onto tamarind xyloglucan by free-radical polymerization...
March 25, 2024: Journal of Materials Science. Materials in Medicine
https://read.qxmd.com/read/38526158/a-graphene-composite-film-based-wearable-far-infrared-therapy-apparatus-graft-for-effective-prevention-of-postoperative-peritoneal-adhesion
#9
JOURNAL ARTICLE
Xiaohuan Lu, Luming Xu, Yu Song, Xiangnan Yu, Qilin Li, Feng Liu, Xiaoqiong Li, Jiangbo Xi, Shuai Wang, Lin Wang, Zheng Wang
Postoperative peritoneal adhesion (PPA) is the most frequent complication after abdominal surgery. Current anti-adhesion strategies largely rely on the use of physical separating barriers creating an interface blocking peritoneal adhesion, which cannot reduce inflammation and suffers from limited anti-adhesion efficacy with unwanted side effects. Here, by exploiting the alternative activated macrophages to alleviate inflammation in adhesion development, a flexible graphene-composite-film (F-GCF) generating far-infrared (FIR) irradiation that effectively modulates the macrophage phenotype toward the anti-inflammatory M2 type, resulting in reduced PPA formation, is designed...
March 25, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38524394/autologous-nanofat-injection-combined-with-fractional-co2-laser-in-the-treatment-of-atrophic-acne-scars
#10
JOURNAL ARTICLE
Mahmoud A Rageh, Shady Mahmoud Attia Ibrahim, Noha Abdallah, Abeer Attia Tawfik
BACKGROUND: Atrophic acne scarring is a widely prevalent condition and one of the most distressing complications of acne vulgaris. Numerous options with variable outcomes are available for the treatment of acne scarring. Laser is considered a first-line therapy for acne scars, and recently there has been a growing interest in using stem cells and their derivatives for treating acne scars. In addition, combined therapeutic modalities often achieve more satisfactory results than a single treatment...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38524043/excision-of-invasive-squamous-cell-carcinoma-complicated-by-osteomyelitis-and-tobacco-use-a-case-report
#11
Harriet Kaye Austin, Gloria M Gamboa, Carlene Waters-Hollingsworth
Squamous cell carcinoma (SCC) is a common type of skin cancer that can be treated through surgical excision using Mohs micrographic surgery (MMS) which results in minimal scarring and low complications. Soft tissue defects as a result of MMS that are too large to be primarily closed can be repaired with secondary intention healing through the use of biologic prosthetics that promote dermal regeneration and tissue remodeling with high success rates. Other non-surgical treatment options include chemotherapy (topical or systemic), radiation, or immunotherapy for advanced skin cancers...
February 2024: Curēus
https://read.qxmd.com/read/38523822/infected-femoral-artery-pseudoaneurysm-ligation-and-revascularisation-a-case-report
#12
Mohammed Alsagheer Alhewy, Ehab Abd Elmoneim Ghazala, Hassan Gado, Wael Abdo Abdo Abd-Elgawad, Ahmed Atef Khamis
KEY CLINICAL MESSAGE: Although ligating femoral pseudoaneurysm is a safe procedure, some cases require revascularization, and the appropriate treatment should be tailored to the patient. ABSTRACT: In this case report, we highlight the challenge in treating infected femoral artery pseudoaneurysm. The patient, a 37-year-old male intravenous drug abuser, presented to the emergency department with a 2-month history of a progressively growing lump over his right groin...
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38522856/severe-liver-dysfunction-after-donor-lymphocyte-infusion-for-relapsed-multiple-myeloma
#13
Tae-Hoon No, Nae-Yun Heo, Seung Ha Park, Joon Hyuk Choi, Junghwan Lee, Sung Nam Lim, Seon Yang Park
Donor lymphocyte infusion (DLI) is performed to augment an anti-tumor immune response or ensure donor stem cells remain engrafted following allogeneic stem cell transplantation but may induce graft-versus-host disease (GVHD) involving skin, intestine, and liver. Although hepatic involvement of GVHD can manifest as mild to severe hepatitis, few reports have mentioned acute severe liver dysfunction with encephalopathy. We experienced a case of acute severe liver dysfunction with semicoma after DLI in a patient with relapsed multiple myeloma following allogeneic stem cell transplantation, in whom chronic viral hepatitis B had been suppressed by antiviral treatment...
March 25, 2024: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://read.qxmd.com/read/38522435/using-an-under-utilised-rural-hospital-to-reduce-surgical-waiting-lists
#14
JOURNAL ARTICLE
Tracey Edwards, Andrea Boerkamp, Kimberley J Davis, Steven Craig
ObjectivesThis study aimed to evaluate patient outcomes from a 12-month pilot program establishing specialist surgical services in a small rural (Modified Monash Model, MM4) hospital on the south coast of NSW.MethodsSuitable patients for ambulatory surgery were selected based on strict anaesthetic, surgical and social criteria. Skills shortfalls among nursing staff, usually with emergency or inpatient experience, were addressed by appropriate re-training and in-service training in scrub, scout and anaesthetic duties...
March 25, 2024: Australian Health Review: a Publication of the Australian Hospital Association
https://read.qxmd.com/read/38521704/follicular-unit-grafting-in-chronic-ulcers-a-valuable-technique-for-integrated-management
#15
JOURNAL ARTICLE
Anahi Belatti, Florencia Bertarini, Virginia Pombo, Luis Mazzuoccolo, Damian Ferrario
Chronic ulcers significantly affect the quality of life of patients and impose a high cost on the healthcare system. The therapeutic management should be comprehensive, taking into consideration the etiological diagnosis of the wound and the characteristics of the wound bed when deciding on a therapeutic proposal appropriate to the healing phase, correcting factors that delay healing. During the epithelialization phase, repair techniques with grafts are recommended to shorten re-epithelialization time, improve the quality of scar tissue, and achieve adequate pain management...
March 22, 2024: Anais Brasileiros de Dermatologia
https://read.qxmd.com/read/38520289/from-admission-to-discharge-a-total-friction-burn-review-from-a-single-institution
#16
JOURNAL ARTICLE
Oscar I Estrada Munoz, Andrew F Sabour, Joseph T Carroll, Carmen E Flores, Douglas R Fraser, Paul Chestovich, Syed F Saquib
While most friction burns are adequately managed in an outpatient setting, many may require hospital admission, operative excision, and extended care. To this day, there is a wide variance in friction burn management. Our goal is to review the etiology, management, and outcomes of such burns warranting hospitalization. We conducted a retrospective review of all friction burns admitted to a single, American Burn Association verified burn center from January 1, 2016 to December 31, 2020. 28 (34%) patients required surgery for their friction burns and 15 (18%) ultimately required a split-thickness skin graft...
March 23, 2024: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://read.qxmd.com/read/38517552/biomechanical-analysis-of-the-human-derived-soft-tissue-graft-epiflex-for-use-in-oral-soft-tissue-augmentation
#17
JOURNAL ARTICLE
Keyvan Sagheb, Robert Noelken, Saskia-Vanessa Schröger, Christian Walter, Julian Jakob Graef, Sven Schumann
PURPOSE: This study aimed to investigate the biomechanical properties, cell migration, and revascularization of the acellular dermal matrix Epiflex. As a decellularized, freeze-dried human skin graft, Epiflex has broad applications in medical fields, particularly in implantology and dentistry. Understanding its biomechanical characteristics is crucial for its clinical adoption as a novel soft tissue graft option. METHODS: Epiflex (n = 3) was evaluated in comparison to palatal tissue from body donors (n = 3)...
March 22, 2024: International Journal of Implant Dentistry
https://read.qxmd.com/read/38515557/treatment-of-cicatricial-lower-eyelid-ectropion-with-suture-of-horner-muscle-combined-with-fascia-transplantation
#18
JOURNAL ARTICLE
Kento Takaya, Shigeki Sakai, Kazuo Kishi
This case series aimed to describe a new technique for correcting contractures and deformities that reliably addresses lacrimal punctum deviation and severe cicatricial lower eyelid ectropion. This was a technical description and a retrospective interventional case series. Eyelid ectropion and lacrimal punctum deviation were treated surgically by grafting the fascia lata and suturing the tarsus-Horner muscle. In total, three patients underwent this surgery: one for burns, one for lower eyelid tumor resection, and the other for an orbital floor fracture following a motorcycle accident, all resulting in ectropion...
March 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38515315/combined-amniotic-membrane-and-self-powered-electrical-stimulator-bioelectronic-dress-promotes-wound-healing
#19
JOURNAL ARTICLE
Yupei Wang, Han Wu, Ao Xiao, Jing Zhu, Jie Qiu, Kuan Yang, Qing Liu, Shengju Hao, Ling Hui, Xin Zhou, Qinzheng Hou, Haixiang Su, Zhaoyan Meng, Lingqian Chang
Human amniotic membranes (hAMs) are widely used as wound management biomaterials, especially as grafts for corneal reconstruction due to the structure of the extracellular matrix and excellent biological properties. However, their fragile nature and rapid degradation rate hinder widespread clinical use. In this work, we engineered a novel self-powered electronic dress (E-dress), combining the beneficial properties of an amniotic membrane and a flexible electrical electrode to enhance wound healing. The E-dress displayed a sustained discharge capacity, leading to increased epidermal growth factor (EGF) release from amniotic mesenchymal interstitial stem cells...
March 21, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38513152/intercalary-resection-of-the-tibia-for-primary-bone-tumors-are-vascularized-fibula-autografts-with-or-without-allografts-a-durable-reconstruction
#20
JOURNAL ARTICLE
Domenico Andrea Campanacci, Roberto Scanferla, Mariagrazia Marsico, Federico Scolari, Guido Scoccianti, Giovanni Beltrami, Luca Delcroix, Marco Innocenti, Rodolfo Capanna
BACKGROUND: Reconstruction with vascularized fibula grafts (VFG) after intercalary resection of sarcoma may offer longevity by providing early graft-host union and fracture healing. The ability of the fibula to hypertrophy under mechanical stress, as well as vascularized bone in the area, may also be advantageous, given that soft tissues may be compromised because of resection, chemotherapy, or radiation therapy. VFG with a massive allograft combines the primary mechanical stability of the graft with the biological potential of the vascularized fibula; however, complications and the durability of this combined reconstruction are not well described...
March 21, 2024: Clinical Orthopaedics and related Research
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