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https://www.readbyqxmd.com/read/28731362/greater-cognitive-deficits-with-sleep-disordered-breathing-among-individuals-with-genetic-susceptibility-to-alzheimer-s-disease-the-multi-ethnic-study-of-atherosclerosis
#1
Dayna A Johnson, Jacqueline Lane, Rui Wang, Michelle Reid, Ina Djonlagic, Annette L Fitzpatrick, Stephen R Rapp, Luenda E Charles, Ruth O'Hara, Richa Saxena, Susan Redline
RATIONALE: There are conflicting findings regarding the link between sleep apnea and cognitive dysfunction. OBJECTIVE: Investigate associations between indicators of sleep-disordered breathing (SDB) and cognitive function in the Multi-Ethnic Study of Atherosclerosis and assess effect modification by the apolipoprotein ε-4 (APOE-ε4) allele. METHODS: A diverse population (N=1,752) underwent Type 2 in-home polysomnography, which included measurement of % sleep time <90% oxyhemoglobin saturation (%Sat<90%) and apnea-hypopnea index (AHI)...
July 21, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28731294/the-bioinorganic-chemistry-of-lead-in-the-context-of-its-toxicity
#2
Wolfgang Maret
Owing to its abundance on earth and its multiple uses by humans, lead (Pb) is a major toxicant that has threatened human health for millennia and continues to do so. There is no safe level of exposure, necessitating a nuanced approach to its control in the food we consume, the water we drink, and the air we breathe. Turnover in soft tissues is within days. In contrast, lead accumulates in bone and turns over with a half-life of about 30 years, though it can be mobilized from bone under physiological and pathophysiological conditions of bone resorption...
April 10, 2017: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/28731072/-evaluation-of-the-results-of-the-prevention-program-protect-your-voice-implemented-by-the-greater-poland-center-of-occupational-medicine-of-poznan
#3
Magdalena Jałowska, Grażyna Wośkowiak, Bożena Wiskirska-Woźnica
BACKGROUND: The aim of the study was to evaluate the rationale for training in voice emission and voice prophylaxis among teachers and to assess the effects of voice disorders rehabilitation in the selected group of teachers participating in the program "Protect your voice." MATERIAL AND METHODS: An anonymous survey was conducted among 463 teachers participating in the training part of the program. The effectivness of rehabilitation of teachers with occupational voice disorders was evaluated among 51 subjects (average age: 43 years) taking part in diagnostic and rehabilitation part of the program...
July 11, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28730888/preoperative-exercise-training-prevents-functional-decline-after-lung-resection-surgery-a-randomized-single-blind-controlled-trial
#4
Raquel Sebio García, Maria Isabel Yáñez-Brage, Esther Giménez Moolhuyzen, Marta Salorio Riobo, Ana Lista Paz, Jose María Borro Mate
OBJECTIVES: To investigate the effects of a preoperative pulmonary rehabilitation programme in patients with lung cancer undergoing video-assisted thoracic surgery. DESIGN: Randomized, single-blind controlled trial. SETTING: Teaching hospital. SUBJECTS: Patients with suspected or confirmed lung cancer undergoing video-assisted thoracic surgery. INTERVENTION: Participants were randomized to either a prehabilitation group or a control group...
August 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28730315/comparison-of-nellcor%C3%A2-pm1000n-and-masimo-radical-7-%C3%A2-for-detecting-apnea-in-volunteers
#5
Chanatthee Kitsiripant, Tomoko Fukada, Hiroko Iwakiri, Yuri Tsuchiya, Makoto Ozaki, Minoru Nomura
PURPOSE: Although capnography is considered the gold standard for monitoring of ventilation, it may not work accurately in some situations. We compared the performance of two non-invasive continuous respiratory rate (RR) monitors that are alternatives for the detection of respiratory depression. METHODS: Fifty healthy volunteers ≥20 years old were enrolled in this study. After monitoring of the volunteers was started by the Masimo Radical-7(®) and Nellcor™ PM1000N, they breathed at the rate of 12 breaths/min for 3 min and then stopped breathing...
July 20, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28730303/exhaled-breath-online-measurement-for-cervical-cancer-patients-and-healthy-subjects-by-proton-transfer-reaction-mass-spectrometry
#6
Wenzhao Zhou, Chaoqun Huang, Xue Zou, Yan Lu, Chengyin Shen, Xiping Ding, Hongzhi Wang, Haihe Jiang, Yannan Chu
Cervical cancer is a common cancer among women and has a high morbidity and mortality. The traditional clinical methods for cervical cancer screening are invasive and limited in terms of cost and time. There is an unmet clinical need for new methods to aid clinicians in the rapid screening and auxiliary diagnosis of cervical precancer. Recently, breath analysis has become an attractive approach for investigation of cancer biomarkers and shows great potential in cancer screening owing to its high sensitivity, quickness, and non-invasive nature...
July 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28730253/fatal-hypersensitivity-pneumonitis-after-chemical-occupational-exposure
#7
Milena Adina Man, Sorin Claudiu Man, Nicoleta Ştefania Motoc, Carmen Monica Pop, Antigona Carmen Trofor
Hypersensitivity pneumonitis (HP; extrinsic allergic alveolitis) is a rare non-immunoglobulin E (IgE)-mediated inflammatory lung disease caused by inhalation exposure (occupational, recreational or ordinary home exposure). A 36-year-old female patient, without significant medical history, is referred to an outpatient pulmonology clinic for dry cough, shortness of breath, fever, fatigue and weight loss. Chest high-resolution computed tomography (HRCT) was performed, and significant lung fibrosis (especially centrilobular and interlobular in bilateral "thick lines"), traction bronchiectasis and alveolitis in both superior lobes are described...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28729675/oxygen-induced-impairment-in-arterial-function-is-corrected-by-slow-breathing-in-patients-with-type-1-diabetes
#8
Luciano Bernardi, Daniel Gordin, Marco Bordino, Milla Rosengård-Bärlund, Anna Sandelin, Carol Forsblom, Per-Henrik Groop
Hyperoxia and slow breathing acutely improve autonomic function in type-1 diabetes. However, their effects on arterial function may reveal different mechanisms, perhaps potentially useful. To test the effects of oxygen and slow breathing we measured arterial function (augmentation index, pulse wave velocity), baroreflex sensitivity (BRS) and oxygen saturation (SAT), during spontaneous and slow breathing (6 breaths/min), in normoxia and hyperoxia (5 L/min oxygen) in 91 type-1 diabetic and 40 age-matched control participants...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729630/mechanically-durable-liquid-impregnated-honeycomb-surfaces
#9
Philip S Brown, Bharat Bhushan
Liquid repellent surfaces typically work by keeping the fouling liquid in a metastable state, with trapped pockets of air between the substrate and the liquid. An alternative method with greater long-term stability utilizes liquid-impregnated surfaces, where the liquid being repelled slides over an immiscible liquid immobilized on a porous surface. Here, we report a method for creating honeycomb surfaces amenable to liquid-impregnation. Polystyrene dissolved in a water-immiscible, volatile solvent was deposited in a humid environment on a variety of substrates to achieve the necessary porosity...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729481/the-art-of-breathing-exchange
#10
Tom Kotsimbos, Gary P Anderson
No abstract text is available yet for this article.
July 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28729388/effects-of-acute-hypoxia-on-human-cognitive-processing-a-study-using-erps-and-seps
#11
Hiroki Nakata, Tadayoshi Miyamoto, Shigehiko Ogoh, Ryusuke Kakigi, Manabu Shibasaki
Although hypoxia has the potential to impair the cognitive function, the effects of acute hypoxia on the high-order brain function (executive and/or inhibitory processing) and somatosensory ascending processing remain unknown. We tested the hypothesis that acute hypoxia impairs both motor executive and inhibitory processing and somatosensory ascending processing. Fifteen healthy subjects performed two sessions (Sessions 1 and 2) consisting of electroencephalographic event-related potentials (ERPs) with somatosensory Go/No-go paradigms and somatosensory-evoked potentials (SEPs) under two conditions (hypoxia and normoxia) on different days...
July 20, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28729347/lethal-avian-influenza-a-h5n1-virus-induces-ataxic-breathing-in-mice-with-apoptosis-of-pre-botzinger-complex-neurons-expressing-neurokinin-1-receptor
#12
Jianguo Zhuang, Na Zang, Chunyan Ye, Fadi Xu
BACKGROUND: Lethal influenza A (H5N1) induces respiratory failure in humans. Although it also causes death at 7 day postinfection (dpi) in mice, the development of the respiratory failure and the viral impact on pre-Botzinger complex (PBC) neurons expressing neurokinin 1 receptor (NK1R), the respiratory rhythm-generator, have not been explored. METHODS: Body temperature, weight, ventilation, arterial blood pH and gases were measured at 0, 2, 4, and 6 dpi in control, lethal HK483 and non-lethal HK486 viral infected mice...
July 20, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28729344/exogenous-stress-hormones-alter-energetic-and-nutrient-costs-of-development-and-metamorphosis
#13
Lucas J Kirschman, Marshall D McCue, Justin G Boyles, Robin W Warne
Variation in environmental conditions during larval life stages can shape development during critical windows and have lasting effects on the adult organism. Changes in larval developmental rates in response to environmental conditions, for example, can trade-off with growth to determine body size and condition at metamorphosis, which can affect adult survival and fecundity. However, it is unclear how use of energy and nutrients shape trade-offs across life stage transitions because no studies have quantified these costs of larval development and metamorphosis...
July 20, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28729039/congenital-myopathy-due-to-myosin-heavy-chain-2-mutation-presenting-as-chronic-aspiration-pneumonia-in-infancy
#14
R Tsabari, H Daum, E Kerem, Y Fellig, T Dor
A 7-week-old infant presented with persistent noisy breathing and aspirations during swallowing. Neurological examination and brain MRI were normal. His 12-year-old brother underwent pneumonectomy at the age of 10 years due to recurrent aspirations leading to severe lung damage. The older brother developed subsequently ophthalmoplegia and nystagmus along with mild weakness of the neck flexors and proximal muscles. Exome analysis revealed homozygosity for a novel truncating mutation p.G800fs27* in the Myosin Heavy Chain 2 (MYH2) gene in both brothers, while parents and an unaffected sibling were heterozygous...
June 27, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28728915/continuous-glucose-monitoring-adds-information-beyond-hba1c-in-well-controlled-diabetes-patients-with-early-cardiovascular-autonomic-neuropathy
#15
Jesper Fleischer, Esben Laugesen, Simon Lebech Cichosz, Pernille Hoeyem, Thomas Fremming Dejgaard, Per Loegstrup Poulsen, Lise Tarnow, Troels Krarup Hansen
AIMS: Hyperglycemia as evaluated by HbA1c is a risk factor for the development of cardiovascular autonomic neuropathy (CAN). The aim of the present study was to investigate whether continuous glucose monitoring (CGM) may add information beyond HbA1c in patients with type 2 diabetes and CAN. METHODS: 81 patients with type 2 diabetes (43 men, mean age 58±11year, HbA1c 6.6±0.5%). Patients were tested for CAN using cardiovascular reflex tests (response to standing, deep breathing and Valsalva maneuver) and underwent CGM for three days...
June 30, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28728620/insulin-resistance-and-hypertension-in-obese-youth-with-sleep-disordered-breathing-treated-with-positive-airway-pressure-a-prospective-multicenter-study
#16
Sherri L Katz, Joanna E MacLean, Lynda Hoey, Linda Horwood, Nicholas Barrowman, Bethany Foster, Stasia Hadjiyannakis, Laurent Legault, Glenda N Bendiak, Valerie G Kirk, Evelyn Constantin
STUDY OBJECTIVES: There is evidence that cardiometabolic disease associated with obesity and sleep-disordered breathing (SDB) in adults is present in youth. SDB is often treated with positive airway pressure (PAP) in youth with obesity. Our aims were to determine: (1) the prevalence of cardiometabolic disease and (2) whether PAP improves markers of cardiometabolic disease, in youth with obesity and newly diagnosed moderate-severe SDB. METHODS: A prospective multicenter cohort study was conducted in youth (8 to 16 years old) with obesity, prescribed PAP therapy for newly diagnosed moderate-severe SDB...
July 14, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28728460/acute-effects-of-moderate-alcohol-consumption-on-postural-stability-in-older-adults
#17
Helen Z Wu, Lisa C Barry, Yinghui Duan, Richard W Bohannon, Jonathan M Covault, James J Grady
This study involved healthy community-living older adults in an investigation of the association between moderate alcohol consumption (AC) and acute changes in postural stability and whether the association differed according to pre-AC balance skills. Thirty-nine moderate drinkers aged ≥ 65 years (62% women; mean age: 73.9 ± 6.1 years) consumed a moderate dose of alcohol (0.4 g/kg; administered as two drinks). Breath alcohol concentration and postural stability were measured at five time points (pre-AC and 40, 80, 120, and 160 minutes post-AC)...
January 1, 2017: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/28727888/association-of-mental-health-status-with-perception-of-nasal-function
#18
Erika Strazdins, Yu Feng Nie, Raziqah Ramli, Tom Palesy, Jenna M Christensen, George Nicholas Marcells, Richard John Harvey
Importance: Mental health issues are thought to be overrepresented among patients undergoing rhinoplasty and may be associated with patient presentation prior to surgery. Objective: To assess the association of poor mental health with perception of nasal function. Design, Setting, and Participants: A cross-sectional study of patients presenting for airway assessment was performed from December 1, 2011, to October 31, 2015, at 2 tertiary rhinoplasty centers in Sydney, Australia...
July 20, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28727669/differential-pulmonary-rehabilitation-outcomes-in-patients-with-and-without-copd-role-of-gender
#19
Lam-Phuong Nguyen, Emily Beck, Katherine Cayetano, Chin-Shang Li, Kimberly Hardin
PURPOSE: Individuals with all forms of pulmonary disease are referred for pulmonary rehabilitation. This study examines pulmonary rehabilitation outcomes between individuals with chronic obstructive lung disease (COPD) and non-COPD disease and the impact of gender. METHODS: This is a retrospective study at a tertiary center. The primary endpoint was the difference in 6-min walk test distance. Secondary measurements included treadmill and NuStep minutes; biceps curls and front arm raises load; quality of life measured by the St George's Respiratory Questionnaire; and University of California San Diego-Shortness of Breath Questionnaire (UCSD-SOBQ) scores...
July 19, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28727649/variables-affecting-intra-abdominal-pressure-during-lifting-in-the-early-postpartum-period
#20
Yvonne Hsu, Robert Hitchcock, Stefan Niederauer, Ingrid E Nygaard, Janet M Shaw, Xiaoming Sheng
OBJECTIVES: Intra-abdominal pressure (IAP) may contribute to pelvic floor health, although the direction and magnitude of such an effect, if any, are not yet known. Identifying individual characteristics, and in particular modifiable factors, associated with higher IAP during recovery from vaginal childbirth might serve to mitigate early pelvic floor dysfunction. The aim of this study was to identify characteristics associated with maximal IAP during lifting in postpartum primiparous women who delivered vaginally...
July 20, 2017: Female Pelvic Medicine & Reconstructive Surgery
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