keyword
https://read.qxmd.com/read/38518059/the-use-of-belimumab-on-patients-with-both-systemic-lupus-erythematosus-and-immune-thrombocytopenia-a-retrospective-cohort-study
#21
JOURNAL ARTICLE
Qi Wu, Ming-Xue Zhao, Xiao-Shan Huang, Chang-Song Lin, Qiang Xu
OBJECTIVE: The objective of this study is to provide a description of a group of retrospective cohort outcomes in patients with systemic lupus erythematosus (SLE) complicated with immune thrombocytopenia (ITP) receiving belimumab. METHODS: This study reports on the treatment of 10 female patients (mean age 34.3 ± 14.0 years, mean weight 58.7 ± 18.2 kg) with both SLE and ITP who received belimumab in addition to basic drug therapy. The belimumab treatment regimen consisted of a dosage of 10 mg/kg, with an initial infusion every 2 weeks for the first 3 doses, followed by an infusion every 4 weeks...
March 22, 2024: Lupus
https://read.qxmd.com/read/38518039/the-effect-of-hyperbaric-oxygen-therapy-on-hematological-indices-and-biochemical-parameters-in-patients-with-diabetic-foot
#22
JOURNAL ARTICLE
Erdinç Ercan, Gamze Aydin, Bülent Erdoğan, Fatih Özçelik
BACKGROUND: Diabetes Mellitus (DM) is a metabolic disease with a high morbidity and mortality and increasing in prevalence all over the world. Due to the hypoxic, ischemic, inflammatory, and infective environment in DM, diabetic foot ulcers have been treated with medico-surgical interventions and adjuvant hyperbaric oxygen Therapy (HBOT). The purpose of this study was to evaluate the effects of HBOT on hematological indices and biochemical parameters in patients with diabetic foot. METHODS: The study group was formed from the file records of 103 male patients who applied to Yunus Emre State Hospital HBOT Center between September 1, 2016 and December 31, 2020, and were treated HBOT with a multidisciplinary approach...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38518025/platelet-index-ratios-in-hiv-emerging-biomarkers-for-immune-health-and-disease-management
#23
JOURNAL ARTICLE
Emmanuel Ifeanyi Obeagu, Getrude Uzoma Obeagu
Human Immunodeficiency Virus (HIV) infection is a global health challenge that requires continuous advancements in diagnostic and prognostic tools. Traditional markers, such as CD4 cell counts and viral load, have played a crucial role in monitoring disease progression and guiding therapeutic interventions. However, emerging research suggests that platelet index ratios may serve as valuable biomarkers in assessing immune health and managing HIV-associated complications. This paper explores the significance of platelet index ratios, including platelet-to-lymphocyte ratio and mean platelet volume-to-lymphocyte ratio, as potential indicators of immune system status in individuals living with HIV...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38516355/case-report-profound-newborn-leukopenia-related-to-a-novel-rac2-variant
#24
Geoffrey Hall, Ágnes Donkó, Cristina Pratt, Julie J Kim-Chang, Paul L Martin, Amy P Stallings, John W Sleasman, Steven M Holland, Amy P Hsu, Thomas L Leto, Talal Mousallem
We report the case of a 1-week-old male born full-term, who had two inconclusive severe combined immunodeficiency (SCID) newborn screens and developed scalp cellulitis and Escherichia coli bacteremia. He did not pass early confirmatory hearing screens. Initial blood counts and lymphocyte flow cytometry revealed profound neutropenia and lymphopenia with a T-/B-/NK- phenotype. Red blood cell adenosine deaminase 1 activity was within normal limits. A presumptive diagnosis of reticular dysgenesis was considered...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38515578/treatment-response-of-advanced-hnscc-towards-immune-checkpoint-inhibition-is-associated-with-an-activated-effector-memory-t-cell-phenotype
#25
JOURNAL ARTICLE
Max Schumacher, Sina Beer, Emmanuelle Moraes Ribeiro, Fulya Korkmaz, Hildegard Keppeler, Rahel Fitzel, Estelle Erkner, Pia Radszuweit, Claudia Lengerke, Corina Schneidawind, Sebastian Hoefert, Paul Stefan Mauz, Dominik Schneidawind
Locally advanced or metastatic head and neck squamous cell carcinoma (HNSCC) is associated with a poor prognosis. The introduction of PD-1 inhibitors has led to a significant improvement in survival, but only a subpopulation of patients responds to therapy. Current biomarkers cannot reliably identify these patients. The identification of biomarkers for the prediction and monitoring of immunotherapy is therefore of great importance. In this study, we characterized lymphocyte subsets in the peripheral blood of HNSCC patients under PD-1 inhibition...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38515568/immune-checkpoint-inhibitor-related-acquired-amegakaryocytosis-thrombocytopenia-a-case-report-and-literature-review
#26
Valérian Rivet, Vincent Sibaud, Jérémie Dion, Thibaut Volosov, Mélanie Biteau, Andréa Pastissier, Karen Delavigne, Pierre Cougoul, Odile Rauzy, Thibault Comont
INTRODUCTION: Immune checkpoint inhibitors (ICIs) are used in several advanced malignancies and may cause various immune-related adverse events (irAEs). Among them, hematological irAEs are less described. Acquired amegakaryocytic thrombocytopenia (AAT) is a rare immune hematologic disorder characterized by severe thrombocytopenia and complete absence of megakaryocytes in bone marrow. CASE PRESENTATION: Herein, we present the case of a patient in their 40s with metastatic melanoma who developed an AAT after 12 cycles of nivolumab (anti-PD1)...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38515567/the-prognostic-value-of-absolute-lymphocyte-count-and-neutrophil-to-lymphocyte-ratio-for-patients-with-metastatic-breast-cancer-a-systematic-review-and-meta-analysis
#27
Bulin Sang, Yuxin Fan, Xurao Wang, Lixian Dong, Yuanyuan Gong, Wenhong Zou, Guanhua Zhao, Jianchang He
BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR) is considered a potential prognostic marker in early breast cancer. However, the prognosis of absolute lymphocyte count (ALC) and NLR in metastatic breast cancer (MBC) has been reported in a few studies, and conclusions are still conflicting. This present manuscript aims to provide further solid evidence regarding the prognostic values of ALC and NLR in MBC patients. METHOD: Eligible studies that reported the associations between ALC or NLR and MBC were included by searching relative electronic databases...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38515094/immune-response-enhancement-by-dietary-supplementation-with-caesalpinia-sappan-extract-in-weaned-pigs-challenged-with-porcine-reproductive-and-respiratory-syndrome-virus
#28
JOURNAL ARTICLE
Chaiwat Arjin, Surat Hongsibsong, Kidsadagon Pringproa, Warintorn Ruksiriwanich, Chompunut Lumsangkul, Jirapat Arunorat, Phongsakorn Chuammitri, Mintra Seel-Audom, Sarana Rose Sommano, Korawan Sringarm
BACKGROUND: At present, porcine reproductive and respiratory syndrome (PRRS) caused by the PRRS virus (PRRSV) is one of the most severe epidemics impacting pig farming globally. Despite the fact that a number of studies have been conducted on potential solutions to this problem, none have proven effective. The focus of problem solving is the use of natural ingredients such as plant extracts. Popular throughout Asia, Caesalpinia sappan (CS) is a therapeutic plant that inhibits PRRSV in vitro...
March 22, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38514311/-characteristics-of-baseline-viral-load-before-antiretroviral-therapy-in-newly-reported-hiv-infected-patients-in-tianjin-2019-2022
#29
JOURNAL ARTICLE
X Zhao, J Y Hou, J J Zhu, M N Zheng, L Li, T L Ning, M H Yu
Objective: To understand the baseline viral load (VL) of newly reported HIV- infected patients before antiretroviral therapy and related factors in Tianjin. Methods: Data were obtained from the China Disease Control and Prevention Information System, and the study subjects were HIV-infected patients before the first antiretroviral therapy in Tianjin from 2019 to 2022, and the information about their socio-demographic characteristics, baseline CD4+ T lymphocyte (CD4) counts before antiretroviral therapy and baseline VL test results were collected, the baseline high VL was defined as ≥100 000 copies/ml...
March 10, 2024: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://read.qxmd.com/read/38514069/the-monocyte-to-lymphocyte-ratio-on-the-6-th-day-postburn-is-associated-with-clinical-outcome-of-severe-burns
#30
JOURNAL ARTICLE
Lizhu Zhi, Yilan Xia, Fang Jin, Xiaojie He, Xingang Wang, Xuanliang Pan
OBJECTIVE: As an immune/inflammatory indicator, the application of monocyte-lymphocyte ratio (MLR) in the treatment of severe burns is lacking. The aim of this study was to investigate the dynamic changes of the MLR value in the early stage of severe burns and its clinical value. METHODS: This is a 5-year retrospective cohort study involving 100 patients with severe burns (II-III degree and total body surface area (TBSA) >50%), in which the lymphocyte count, monocyte count, MLR value, C-reactive protein (CRP), creatinine (Scr), and capillary leakage index (CLI) were evaluated soon after injury, and 30-day mortality rates were investigated...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38513331/inflammatory-blood-cells-and-ratios-at-remission-for-psychosis-relapse-prediction-a-three-year-follow-up-of-a-cohort-of-first-episodes-of-schizophrenia
#31
JOURNAL ARTICLE
Vicent Llorca-Bofí, Santiago Madero, Silvia Amoretti, Manuel J Cuesta, Carmen Moreno, Ana González-Pinto, Dani Bergé, Roberto Rodriguez-Jimenez, Alexandra Roldán, María Ángeles García-León, Angela Ibáñez, Judith Usall, Fernando Contreras, Gisela Mezquida, Clemente García-Rizo, Esther Berrocoso, Miquel Bernardo, Miquel Bioque
BACKGROUND: The clinical course following a first episode of schizophrenia (FES) is often characterized by recurrent relapses, resulting in unfavorable clinical and functional outcomes. Inflammatory dysregulation has been implicated in relapse risk; however, the predictive value of inflammatory blood cells in clinically remitted patients after a FES has not been previously explored. METHODS: In this study, we closely monitored 111 patients in remission after a FES until relapse or a three-year follow-up endpoint...
March 20, 2024: Schizophrenia Research
https://read.qxmd.com/read/38512862/immune-dysfunction-mediated-by-the-competitive-endogenous-rna-network-in-fetal-side-placental-tissue-of-polycystic-ovary-syndrome
#32
JOURNAL ARTICLE
Ningning Xie, Fangfang Wang, Danqing Chen, Jue Zhou, Jian Xu, Fan Qu
Polycystic ovary syndrome (PCOS), a common endocrine and metabolic disorder affecting women in their reproductive years. Emerging evidence suggests that the maternal-fetal immune system is crucial for proper pregnancy. However, whether immune function is altered at the end of pregnancy in PCOS women and the underlying molecular mechanisms is currently unexplored. Herein, the basic maternal immune system was investigated (n = 136 in the control group; n = 103 in the PCOS group), and whole-transcriptome sequencing was carried out to quantify the mRNAs, miRNAs, and lncRNAs expression levels in fetal side placental tissue of women with PCOS...
2024: PloS One
https://read.qxmd.com/read/38512721/paradoxical-imbalance-between-activated-lymphocyte-protein-synthesis-capacity-and-rapid-division-rate
#33
JOURNAL ARTICLE
Mina O Seedhom, Devin Dersh, Jaroslav Holly, Mariana Pavon-Eternod, Jiajie Wei, Matthew Angel, Lucas Shores, Alexandre David, Jefferson Santos, Heather Hickman, Jonathan W Yewdell
Rapid lymphocyte cell division places enormous demands on the protein synthesis machinery. Flow cytometric measurement of puromycylated ribosome-associated nascent chains after treating cells or mice with translation initiation inhibitors reveals that ribosomes in resting lymphocytes in vitro and in vivo elongate at typical rates for mammalian cells. Intriguingly, elongation rates can be increased up to 30% by activation in vivo or fever temperature in vitro. Resting and activated lymphocytes possess abundant monosome populations, most of which actively translate in vivo, while in vitro, nearly all can be stalled prior to activation...
March 21, 2024: ELife
https://read.qxmd.com/read/38512512/clinical-features-and-risk-factors-of-primary-sj%C3%A3-gren-s-syndrome-complicated-with-severe-pneumonia-a-case-control-study
#34
JOURNAL ARTICLE
Bo Cai, Zhiliang Guo, Qing Yan, Hui Li, Hua Song, Yan Gong, Xianming Long
OBJECTIVES: To analyze clinical characteristics, risk factors, pathogen distribution, and prognostic markers in primary Sjögren's syndrome (pSS) patients with severe pneumonia (SP) compared to those without severe pneumonia (NSP). METHODS: This case-control study included 24 hospitalized pSS patients with SP and 96 NSP at the first affiliated hospital of Soochow university from June 2014 to May 2023. Data encompassing demographics, comorbidities, treatments, and laboratory results were retrospectively collected...
March 21, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38512368/the-predictive-value-of-systemic-inflammatory-markers-in-902-patients-with-tunneled-hemodialysis-catheter
#35
JOURNAL ARTICLE
Melis Baykara Ulusan, Emine Meltem, Ilhan Nahit Mutlu, Kivilcim Ulusan
AIM: This study aimed to assess the predictive role of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and mean platelet volume, on catheter survival in chronic hemodialysis patients, analyzing both infectious and non-infectious complications. METHODS: A retrospective analysis encompassed 1279 tunneled catheter insertion procedures involving 902 patients between March 2014 and October 2018. Patients were categorized into two main groups: (i) initial placement and (ii) exchange...
March 21, 2024: Journal of Nephrology
https://read.qxmd.com/read/38511530/immunological-parameters-of-maternal-peripheral-blood-as-predictors-of-future-pregnancy-outcomes-in-patients-with-unexplained-recurrent-pregnancy-loss
#36
JOURNAL ARTICLE
Yingrong Li, Irene X Y Wu, Xuan Wang, Jinlu Song, Quan Chen, Weiru Zhang
INTRODUCTION: Unexplained recurrent pregnancy loss (URPL), affecting approximately 1%-5% of women, exhibits a strong association with various maternal factors, particularly immune disorders. However, accurately predicting pregnancy outcomes based on the complex interactions and synergistic effects of various immune parameters without an automated algorithm remains challenging. MATERIAL AND METHODS: In this historical cohort study, we analyzed the medical records of URPL patients treated at Xiangya Hospital, Changsha, China, between January 2020 and October 2022...
March 21, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38510007/immune-stimulatory-effect-of-nigella-sativa-in-healthy-animal-models-a-systematic-review-and-meta-analysis
#37
JOURNAL ARTICLE
Abdulsamad Alsalahi, Nian N N Maarof, Mohammed A Alshawsh, Musheer A Aljaberi, Mousa A Qasem, Abdulaleem Mahuob, Nassrin A Badroon, Ebthag A M Mussa, Rukman A Hamat, Atiyah M Abdallah
The immune-modulatory effects of black seeds ( Nigella sativa seeds, NSS) are well documented, but the overall in vivo impact of this important natural medicinal product on immune system function has yet to be established. Here we systematically reviewed and meta-analyzed the effects of NSS on humoral [serum titers of immunoglobulins including IgG, IgM, anti-Newcastle virus disease (anti-NDV), and sheep red blood cell antigen (anti-SRBC)] and cellular immunity [total white blood cell (WBC) count and percentages of monocytes, lymphocytes, basophils, neutrophils, and eosinophils] in healthy animals...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38509769/mait-cells-are-associated-with-responsiveness-to-neoadjuvant-immunotherapy-in-copd-associated-nsclc
#38
JOURNAL ARTICLE
Yanze Yin, Ao Zeng, Abudumijiti Abuduwayiti, Zhilong Xu, Keyi Chen, Chao Wang, Xinyun Fang, Jiarui Wang, Gening Jiang, Jie Dai
BACKGROUND: Patients with non-small cell lung cancer (NSCLC) and chronic obstructive pulmonary disease (COPD) experience worse clinical outcomes but respond better to immunotherapy than patients with NSCLC without COPD. Mucosal-associated invariant T (MAIT) cells, a versatile population of innate immune T lymphocytes, have a crucial function in the response to infection and tumors. This study investigated the distribution of MAIT cells in COPD-associated NSCLC and their involvement in the immune response...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38509387/monocyte-to-high-density-lipoprotein-ratio-and-systemic-immune-inflammation-index-potential-parameters-for-the-evaluation-of-disease-activity-and-severity-in-graves-ophthalmopathy
#39
JOURNAL ARTICLE
Büşra Yılmaz Tuğan, Abdullah Ergen, Berna Özkan
PURPOSE: To assess changes in monocyte-to-high-density lipoprotein (HDL) ratio (MHR), neutrophil-to-lymphocyte ratio (NLR), and systemic immune-inflammation index (SII) with Graves' ophthalmopathy (GO) and their possible relation with GO disease activity and severity. METHODS: A total of 20 patients with GO and 24 healthy controls were involved in the study. The thyroid status, MHR (monocyte count/HDL cholesterol level), NLR (neutrophil count/lymphocyte count) and SII [(neutrophil count × platelet count)/lymphocyte count] were compared between the groups...
March 21, 2024: International Ophthalmology
https://read.qxmd.com/read/38508274/biomonitoring-of-polycyclic-aromatic-hydrocarbons-exposure-and-short-time-health-effects-in-wildland-firefighters-during-real-life-fire-events
#40
JOURNAL ARTICLE
Ana Margarida Paiva, Bela Barros, Marta Oliveira, Sara Alves, Filipa Esteves, Adília Fernandes, Josiana Vaz, Klára Slezáková, João Paulo Teixeira, Solange Costa, Simone Morais
Human biomonitoring data retrieved from real-life wildland firefighting in Europe and, also, worldwide are scarce. Thus, in this study, 176 Portuguese firefighters were biomonitored pre- and post- unsimulated wildfire combating (average:12-13 h; maximum: 55 h) to evaluate the impact on the levels of urinary polycyclic aromatic hydrocarbons hydroxylated metabolites (OHPAH; quantified by high-performance liquid chromatography with fluorescence detection) and the associated short-term health effects (symptoms, and total and differentiated white blood cells)...
March 18, 2024: Science of the Total Environment
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