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https://www.readbyqxmd.com/read/29334554/the-systemic-immune-inflammation-index-independently-predicts-survival-and-recurrence-in-resectable-pancreatic-cancer-and-its-prognostic-value-depends-on-bilirubin-levels-a-retrospective-multicenter-cohort-study
#1
Mohammad Hosein Aziz, Kostandinos Sideras, Nasir Ahmad Aziz, Katya Mauff, Roel Haen, Daphne Roos, Lawlaw Saida, Mustafa Suker, Erwin van der Harst, Jan Sven Mieog, Bert A Bonsing, Yarne Klaver, Bas Groot Koerkamp, Casper H van Eijck
OBJECTIVE: Our aim was to determine the prognostic significance of the systemic-immune-inflammation index (SIII) in patients with resectable pancreatic cancer, using cancer-specific survival as the primary outcome. BACKGROUND: Pancreatic cancer is associated with a dysfunctional immune system and poor prognosis. We examined the prognostic significance of the SIII in patients with resectable pancreatic ductal adenocarcinoma (PDAC) and the effects of bilirubin on this index...
January 12, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29333619/surrogate-scale-for-evaluating-respiratory-function-based-on-complete-blood-count-parameters
#2
Yang Guang, Zhou Jie, Dong Feng, Liu Hui
BACKGROUND: In this study, we aimed to identify a simple method for evaluating respiratory function using complete blood count parameters. METHODS: The complete blood count parameters, including red blood cell (RBC) count, hemoglobin (Hb) level, lymphocyte (Lym) and platelet (Plt) count, and partial pressure of oxygen (PO2 ) level, were measured using automated analyzers in patients with chronic obstructive pulmonary disease (COPD), aged subjects, and young subjects (control group)...
January 15, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29333081/innate-immunity-recovers-earlier-than-acquired-immunity-during-severe-postoperative-immunosuppression
#3
Gunnar Lachmann, Clarissa von Haefen, Johannes Kurth, Fatima Yuerek, Claudia Spies
Background: Postoperative immune suppression, particularly a loss of cell-mediated immunity, is commonly seen after surgery and is associated with worse outcome, i.e. delayed wound healing, infections, sepsis, multiple-organ failure and cancer recurrence. However, the recovery of immune cells focusing on differences between innate and acquired immunity during severe postoperative immunosuppression is not investigated. Methods: In this retrospective randomized controlled trial (RCT) subgroup analysis, 10 postoperatively immune suppressed patients after esophageal or pancreatic resection were analyzed...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29333021/efficacy-and-safety-of-ibrutinib-in-indian-patients-with-relapsed-or-refractory-chronic-lymphocytic-leukemia-and-mantle-cell-lymphoma-cases-from-a-named-patient-program
#4
Mohan B Agarwal, Dinesh Bhurani, Chirag Shah, Nitin Sood, Manish Singhal, Anil Kamat, Subash Chezhian, Suryaprakash Mishra, Dinesh Nagrale
Context: This named patient program evaluated the safety and efficacy of ibrutinib, a selective inhibitor of Bruton's tyrosine kinase in Indian patients with relapsed/refractory chronic lymphocytic leukemia (CLL, with/without chromosome 17 deletion [del17p]) and mantle cell lymphoma (MCL). Subjects and Methods: The eight enrolled patients (relapsed/refractory CLL: n = 6 [4/6 patients with del17p] and relapsed/refractory MCL: n = 2) had median age of 55 years (range, 52-60) and had received a median of 3 (CLL patients) and 4 (MCL patients) prior therapies...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29331737/hematology-reference-intervals-for-neonatal-holstein-calves
#5
Nikolaos Panousis, Nektarios Siachos, Georgios Kitkas, Emmanouil Kalaitzakis, Maria Kritsepi-Konstantinou, Georgios E Valergakis
Data regarding hematologic reference intervals (RI) for neonatal calves have not been published yet. The aims of this study were: a) to establish hematology RIs for neonatal Holstein calves, b) to compare them with the RIs for lactating cows, and c) to investigate the relationship of age and gender with the hematologic profile of calves. Two-hundred and fifty-four clinically healthy Holstein calves (1-9days old, from 30 farms) and 82 healthy Holstein cows (between 30 and 150days in milk, from 10 farms) were blood sampled once for a complete blood count evaluation, using the ADVIA 120 hematology analyzer...
January 9, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29327065/blood-predictive-biomarkers-for-nivolumab-in-advanced-melanoma
#6
Edouard Chasseuil, Mélanie Saint-Jean, Hannah Chasseuil, Lucie Peuvrel, Gaëlle Quéreux, Jean-Michel Nguyen, Aurélie Gaultier, Emilie Varey, Amir Khammari, Brigitte Dréno
Nivolumab response rate is 40% in metastatic melanoma. Few studies have evaluated pre-treatment biomarkers predictive of response. The aim of this study was to identify potential peripheral blood biomarkers associated with survival in patients with advanced melanoma treated with nivolumab. All advanced melanoma cases treated with anti-programmed cell death protein 1 (anti-PD1) over a 3-year period in our department were identified. For each case, 9 potential blood biomarkers were identified. Bivariate and multivariate analyses, adjusted for the American Joint Committee on Cancer (AJCC) classification stage, Eastern Cooperative Oncology Group (ECOG) performance status, lactate dehydrogenase (LDH) level and failure to respond to first-line therapy, were used to test the association between biomarkers and overall survival (primary outcome) or progression-free survival (secondary outcome)...
December 20, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29326085/frailty-and-leucocyte-count-are-predictors-of-all-cause-mortality-and-hospitalization-length-in-non-demented-institutionalized-older-women
#7
Julio Fernandez-Garrido, Vicente Ruiz-Ros, Rut Navarro-Martínez, Cristina Buigues, Mary Martínez-Martínez, Yolanda Verdejo, Laura Sanantonio-Camps, Mª Carmen Mascarós, Omar Cauli
Alteration in the immune system such as the number of white blood cells count (WBC) has been associated with frailty syndrome but their role in institutionalized older individuals have been rarely investigated. We evaluated the relationships between white blood cell subtypes, geriatric assessment, depression and frailty syndrome based on the criteria of physical phenotype. In particular, we aimed to analyze by a two-year follow-up and prospective study the predictive value of alterations in WBC, frailty and functional impairment in terms of hospitalizations and all-cause mortality in institutionalized older women...
January 8, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29325709/acute-hyperoxia-induces-systemic-responses-with-no-major-changes-in-peripheral-tissues-in-the-senegalese-sole-solea-senegalensis-kaup-1858
#8
Marina Machado, Diogo Malheiro, Ana Couto, Jonathan M Wilson, Matthew Guerreiro, Rita Azeredo, Jon C Svendsen, António Afonso, Renata Serradeiro, Benjamín Costas
Senegalese sole Solea senegalensis is currently farmed in recirculation aquaculture systems that often involve water re-oxygenation, which in turn may cause acute or prolonged hyperoxia exposures. In order to understand the impact of acute hyperoxia on the fish immune system and peripheral tissues such as gills and gut, Senegalese sole juveniles (30.05 ± 1.72 g) were exposed to normoxia (100% O2sat) as control and two hyperoxic conditions (150 and 200% O2sat) and sampled at 4 and 24 h. Fish haematological profile, total and differential blood cell counts and plasma immune parameters were analysed...
January 8, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29325504/platelet-to-lymphocyte-ratio-neutrophil-to-lymphocyte-ratio-and-platelet-indices-in-patients-with-acute-deep-vein-thrombosis
#9
Liang Ming, Zhiyun Jiang, Junfen Ma, Qian Wang, Fan Wu, Jiedan Ping
BACKGROUND: Inflammation is associated with an increased risk of thrombotic events and complete blood count (CBC) is an easily measured test. The purpose of this study was to evaluate the value of CBC relative parameters including mean platelet volume (MPV), platelet-to-lymphocyte ratio (PLR), mean platelet volume-to-lymphocyte ratio (MPVLR), and neutrophil-to-lymphocyte ratio (NLR) for patients with acute deep vein thrombosis (DVT). PATIENTS AND METHODS: A total of 115 patients with unprovoked DVT of the lower extremities and 105 controls were recruited in this study...
January 12, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29325308/-opportunistic-infection-in-systemic-lupus-erythematosus-patients-the-disease-spectrum-and-the-characteristics-of-peripheral-lymphocyte-subsets
#10
L Qin, Z F Qiu, J Xie, T R Geng, J L Zhao, L Wan, T S Li
Objective: To investigate the common opportunistic infections and the characteristics of peripheral lymphocyte subsets in patients with systemic lupus erythematosus (SLE). Methods: From December 2013 to December 2016, peripheral lymphocyte subsets were consecutively detected by flow cytometry in treated SLE patients with or without opportunistic infections (OIs) . The lymphocyte subsets in healthy donors were used as normal control group. Results: A total of 145 treated SLE patients were enrolled including 108 with OIs and 37 without OIs...
January 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29324972/prognostic-and-predictive-role-of-neutrophil-lymphocytes-ratio-in-metastatic-colorectal-cancer-a-retrospective-analysis-of-the-tribe-study-by-gono
#11
E Dell'Aquila, C Cremolini, T Zeppola, S Lonardi, F Bergamo, G Masi, M Stellato, F Marmorino, M Schirripa, F Urbano, M Ronzoni, G Tomasello, A Zaniboni, P Racca, A Buonadonna, G Allegrini, E Fea, S Di Donato, S Chiara, G Tonini, D Tomcikova, L Boni, A Falcone, D Santini
Background: Neutrophil/Lymphocyte ratio (NLR), defined as absolute neutrophils count divided by absolute lymphocytes count, has been reported as poor prognostic factor in several neoplastic diseases but only a few data are available about unresectable metastatic colorectal cancer (mCRC) patients (pts). The aim of our study was to evaluate the prognostic and predictive role of NLR in the TRIBE trial. Patients and Methods: Pts enrolled in TRIBE trial were included...
January 8, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29324763/factors-associated-with-urinary-tract-infections-among-hiv-1-infected-patients
#12
Agata Skrzat-Klapaczyńska, Bartłomiej Matłosz, Agnieszka Bednarska, Marcin Paciorek, Ewa Firląg-Burkacka, Andrzej Horban, Justyna D Kowalska
BACKGROUND: Urinary tract infections remain an important yet underinvestigated clinical problem among HIV infected patients. Here we analyze factors associated with its occurrence and the spectrum of bacterial pathogens identified in the group of patients followed at the HIV Out-Patient Clinic in Warsaw. METHODS: Clinic database collected all medical information on patients routinely followed since 1994 to 2015. All patients with available urine culture were included into analyses, only the first culture was included...
2018: PloS One
https://www.readbyqxmd.com/read/29321927/pulmonary-nocardiosis-in-a-patient-with-idiopathic-cd4-t-lymphocytopenia
#13
Vivek Jayaschandran, Sandra Gjorgova-Gjeorgjievski, Haamid Siddique
Idiopathic CD4 T-lymphocytopenia (ICL) is a rare immunodeficiency characterized by low CD4 T-lymphocyte count, which usually manifests with opportunistic infections. Nocardia as an opportunistic pathogen infecting patients with this condition has rarely been reported. Here, we describe the case of a 46-year-old male who presented with lung mass and respiratory and systemic symptoms and was eventually diagnosed with pulmonary nocardiosis. A workup for predisposing immunodeficiencies suggested a picture of ICL...
February 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29321527/a-hospital-based-retrospective-study-of-factors-influencing-therapeutic-leukapheresis-in-patients-presenting-with-hyperleukocytic-leukaemia
#14
Yanxia Jin, Shishang Guo, Qin Cui, Sichao Chen, Xiaoping Liu, Yongchang Wei, Yunbao Pan, Liang Tang, Tingting Huang, Hui Shen, Guanghui Xu, Xuelan Zuo, Shangqin Liu, Hui Xiao, Fei Chen, Fayun Gong, Fuling Zhou
Therapeutic leukapheresis is a rapid and effective method to reduce early mortality of patients with hyperleukocytic leukaemia (HLL). However, few studies on factors influencing the efficiency have been reported. In this study, 67 cases who underwent leukapheresis were retrospectively analysed and factors related to the collection efficiency of leukapheresis (CEWBC) were also evaluated. Paired t test showed that there was a significant decrease in statistics of white blood cell (WBC) counts after apheresis...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320521/cd8-t-cell-infiltration-in-breast-and-colon-cancer-a-histologic-and-statistical-analysis
#15
James Ziai, Houston N Gilbert, Oded Foreman, Jeffrey Eastham-Anderson, Felix Chu, Mahrukh Huseni, Jeong M Kim
The prevalence of cytotoxic tumor infiltrating lymphocytes (TILs) has demonstrated prognostic value in multiple tumor types. In particular, CD8 counts (in combination with CD3 and CD45RO) have been shown to be superior to traditional UICC staging in colon cancer patients and higher total CD8 counts have been associated with better survival in breast cancer patients. However, immune infiltrate heterogeneity can lead to potentially significant misrepresentations of marker prevalence in routine histologic sections...
2018: PloS One
https://www.readbyqxmd.com/read/29319242/clinical-diversity-of-cns-cryptococcosis
#16
J M Koshy, S Mohan, D Deodhar, M John, A Oberoi, A Pannu
Background: Though cryptococcal meningitis (CM) is recognized as a disease of the immunocompromised, studies have implicated that it also affect immunocompetent patients. Methodology: This was a cross sectional study conducted in the Department of Medicine of a tertiary teaching institution in North India. All the patients diagnosed with CM on the basis of detection of cryptococcal antigen or the presence of capsulated budding yeast cells on India ink preparation, from April 2009 to March2015 were included in the study...
October 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29317823/european-perspective-on-the-management-of-rheumatoid-arthritis-clinical-utility-of-tofacitinib
#17
REVIEW
Paweł Kawalec, Katarzyna Śladowska, Iwona Malinowska-Lipień, Tomasz Brzostek, Maria Kózka
Xeljanz® (tofacitinib) is an oral small-molecule inhibitor that reversibly inhibits Janus-activated kinase (JAK)-dependent cytokine signaling, thus reducing inflammation. As a result of these mechanisms, effects on the immune system such as a moderate decrease in the total lymphocyte count, a dose-dependent decrease in natural killer (NK) cell count, and an increase in B-cell count have been observed. Therefore, tofacitinib provides an innovative approach to modulating the immune and inflammatory responses in patients with rheumatoid arthritis (RA), which is especially important in individuals who do not respond to tumor necrosis factor inhibitors or show a loss of response over time...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29314650/validation-of-reflex-testing-rules-and-establishment-of-a-new-workflow-for-body-fluid-cell-analysis-using-a-sysmex-xn-550-automatic-hematology-analyzer
#18
Y-U Cho, E You, S Jang, C-J Park
INTRODUCTION: We developed and validated reflex testing rules for the microscopic examination (ME) of body fluids (BFs) on the Sysmex XN-550 (Sysmex Corporation) instrument. METHODS: We assessed the detection limits, precision, linearity, and carryover. To develop the reflex testing rules (derivation arm), we tested 515 samples and then validated the rules using another 507 samples (validation arm). RESULTS: All analytical performances were acceptable, and the carryover was negligible...
January 4, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29313439/the-potential-association-of-cmv-specific-cd8-t-lymphocyte-reconstitution-with-the-risk-of-cmv-reactivation-and-persistency-in-post-allogeneic-stem-cell-transplant-patients
#19
Ahmed Ali Shams El-Din, Nermeen Ahmed El-Desoukey, Dalia Gamil Amin Tawadrous, Neveen Mohammed Baha El-Din Fouad, Mohammed Abdel-Mooti, Said Fathy Hotar
OBJECTIVES: development of cytomegalovirus (CMV)-specific CD8+ T cell response is crucial in preventing symptomatic CMV infection specially, in stem cell transplant (SCT) patients. The aim of this study was to evaluate CMV-specific CD8+ T cell reconstitution in allogeneic SCT recipients and to study the possible association between CMV-specific CD8+ T cell recovery with protection from CMV reactivation and persistency. METHODS: Human leuKocyte antigen (HLA)-tetramers were used for CMV-specific CD8+ cell quantitation by Flow cytometry in twenty post-allogeneic SCT patients...
January 9, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29312621/elevated-red-blood-cell-distribution-width-predicts-poor-prognosis-in-hilar-cholangiocarcinoma
#20
Bei Li, Zhen You, Xian-Ze Xiong, Yong Zhou, Si-Jia Wu, Rong-Xing Zhou, Jiong Lu, Nan-Sheng Cheng
Background: Although the red blood cell distribution width (RDW) has been reported as a reliable predictor of prognosis in several types of cancer, the prognostic value of RDW in hilar cholangiocarcinoma (HC) has not been studied. Methods: A retrospective analysis of 292 consecutively recruited HC patients undergoing radical resection was conducted. The optimal cutoff value of RDW was determined by the receiver operating characteristic curve (ROC). Survival analysis by the Kaplan-Meier method, the difference between the clinico-pathologic variables and survival were evaluated by log-rank analysis...
December 12, 2017: Oncotarget
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