keyword
MENU ▼
Read by QxMD icon Read
search

Parkinson disease and resting connectivity

keyword
https://www.readbyqxmd.com/read/29769626/the-cholinergic-contribution-to-the-resting-state-functional-network-in-non-demented-parkinson-s-disease
#1
Yoonju Lee, Jee Hyun Ham, Jungho Cha, Yeong-Hun Park, Jae Jung Lee, Mun Kyung Sunwoo, Jin Yong Hong, Young H Sohn, Jong-Min Lee, Phil Hyu Lee
The cholinergic system arising from the basal forebrain plays an important role in cognitive performance in Parkinson's disease (PD). Here, we analyzed cholinergic status-dependent cortical and subcortical resting-state functional connectivity in PD. A total of 61 drug-naïve PD patients were divided into tertiles based on normalized substantia innominata (SI) volumes. We compared the resting-state network from seed region of interest in the caudate, posterior cingulate cortex (PCC), and SI between the lowest (PD-L) and highest tertile (PD-H) groups...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29755401/impulsivity-in-parkinson-s-disease-is-associated-with-alterations-in-affective-and-sensorimotor-striatal-networks
#2
Marit F L Ruitenberg, Tina Wu, Bruno B Averbeck, Kelvin L Chou, Vincent Koppelmans, Rachael D Seidler
A subset of patients with Parkinson's disease (PD) experiences problems with impulse control, characterized by a loss of voluntary control over impulses, drives, or temptations regarding excessive hedonic behavior. The present study aimed to better understand the neural basis of such impulse control disorders (ICDs) in PD. We collected resting-state functional connectivity and structural MRI data from 21 PD patients with ICDs and 30 patients without such disorders. To assess impulsivity, all patients completed the Barratt Impulsiveness Scale and performed an information-gathering task...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29728527/disrupted-hypothalamic-functional-connectivity-in-patients-with-pd-and-autonomic-dysfunction
#3
Eran Dayan, Miriam Sklerov, Nina Browner
OBJECTIVE: To test whether symptoms of autonomic dysfunction in Parkinson disease (PD) are associated with alterations in intrinsic hypothalamic functional connectivity, given the regulatory role of the hypothalamus (HTH) in the autonomic nervous system. METHODS: Resting-state fMRI scans from patients with PD were analyzed, comparing patients with the highest (n = 24) and lowest (n = 28) quartile scores in a questionnaire assessing autonomic dysfunction in PD (Scales for Outcomes in Parkinson's Disease-Autonomic [SCOPA-AUT]), obtained from a larger pool of patients (n = 93)...
May 4, 2018: Neurology
https://www.readbyqxmd.com/read/29701820/cerebello-cortical-network-fingerprints-differ-between-essential-parkinson-s-and-mimicked-tremors
#4
Muthuraman Muthuraman, Jan Raethjen, Nabin Koirala, Abdul Rauf Anwar, Kidist G Mideksa, Rodger Elble, Sergiu Groppa, Günter Deuschl
Cerebello-thalamo-cortical loops play a major role in the emergence of pathological tremors and voluntary rhythmic movements. It is unclear whether these loops differ anatomically or functionally in different types of tremor. We compared age- and sex-matched groups of patients with Parkinson's disease or essential tremor and healthy controls (n = 34 per group). High-density 256-channel EEG and multi-channel EMG from extensor and flexor muscles of both wrists were recorded simultaneously while extending the hands against gravity with the forearms supported...
April 26, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29673605/rest-tremor-quantification-based-on-fuzzy-inference-systems-and-wearable-sensors
#5
Luis A Sanchez-Perez, Luis P Sanchez-Fernandez, Adnan Shaout, Juan M Martinez-Hernandez, Maria J Alvarez-Noriega
BACKGROUND: Currently the most consistent, widely accepted and detailed instrument to rate Parkinson's disease (PD) is the Movement Disorder Society sponsored Unified Parkinson Disease Rating Scale (MDS-UPDRS). However, the motor examination is based upon subjective human interpretation trying to capture a snapshot of PD status. Wearable sensors and machine learning have been broadly used to analyze PD motor disorder, but still most ratings and examinations lay outside MDS-UPDRS standards...
June 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29606606/gender-specific-effect-of-uric-acid-on-resting-state-functional-networks-in-de-novo-parkinson-s-disease
#6
Yoonju Lee, Yeong-Hun Park, Jae Jung Lee, Young H Sohn, Jong-Min Lee, Phil Hyu Lee
INTRODUCTION: The pattern of resting-state networks is influenced by several factors besides the underlying pathological changes of Parkinson's disease (PD). Uric acid (UA), as an antioxidant, has a neuroprotective property against PD-related microenvironment; however, this effect would be gender-specific. We aimed to evaluate a gender-sensitive resting-state networks (RSN) according to the UA level in drug naïve de novo patients with PD to elucidate the role of antioxidant in cortical functional networks of PD...
March 26, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29602542/decreased-interhemispheric-homotopic-connectivity-in-parkinson-s-disease-patients-with-freezing-of-gait-a-resting-state-fmri-study
#7
Junyi Li, Yongsheng Yuan, Min Wang, Jiejin Zhang, Li Zhang, Siming Jiang, Xixi Wang, Jian Ding, Kezhong Zhang
INTRODUCTION: Freezing of gait is a common complaint in patients with Parkinson's disease (PD). However, the neural bases of freezing of gait in PD remain uncertain. Existing studies on PD patients with freezing of gait (PD-FOG+) have reported damage of the corpus callosum, the largest commissural bundle of the brain. Thus, in this study we explored homotopic connectivity to investigate FOG-related interehemispheric alterations METHODS: A total of 21 PD-FOG + patients, 33 PD patients without freezing of gait (PD-FOG-), and 24 matched healthy controls were recruited...
March 26, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29567424/altered-intrinsic-brain-functional-connectivity-in-drug-na%C3%A3-ve-parkinson-s-disease-patients-with-lrrk2-mutations
#8
Yanbing Hou, Chunyan Luo, Jing Yang, Ruwei Ou, Wei Song, Yongping Chen, Qiyong Gong, Huifang Shang
BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) has been recently identified as a causative gene of Parkinson's disease (PD), and the LRRK2 R1628P and G2385R mutations are common in ethnic Han-Chinese PD patients. However, the pathogenic mechanism of LRRK2 mutations in PD remains largely unknown. METHODS: Resting-state functional MRI (fMRI) was used to assess the functional connectivity (FC) of the striatal subregions of 11 ethnic Han-Chinese drug-naïve PD patients with the LRRK2 R1628P or G2385R mutations, 11 ethnic Han-Chinese drug-naïve PD patients without such mutations, and 22 healthy control (HC) subjects...
March 19, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29555381/striatal-changes-in-parkinson-disease-an-investigation-of-morphology-functional-connectivity-and-their-relationship-to-clinical-symptoms
#9
Conor Owens-Walton, David Jakabek, Xiaozhen Li, Fiona A Wilkes, Mark Walterfang, Dennis Velakoulis, Danielle van Westen, Jeffrey C L Looi, Oskar Hansson
We sought to investigate morphological and resting state functional connectivity changes to the striatal nuclei in Parkinson disease (PD) and examine whether changes were associated with measures of clinical function. Striatal nuclei were manually segmented on 3T-T1 weighted MRI scans of 74 PD participants and 27 control subjects, quantitatively analysed for volume, shape and also functional connectivity using functional MRI data. Bilateral caudate nuclei and putamen volumes were significantly reduced in the PD cohort compared to controls...
March 7, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29530489/abnormal-ventral-tegmental-area-anterior-cingulate-cortex-connectivity-in-parkinson-s-disease-with-depression
#10
Luqing Wei, Xiao Hu, Yonggui Yuan, Weiguo Liu, Hong Chen
Neuropathology suggests that Parkinson's disease (PD) with depression may involve a progressive degeneration of the nigrostriatal and mesocorticolimbic dopaminergic systems. Previous positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies have shown that dopamine changes in individual brain regions constituting the nigrostriatal and mesocorticolimbic circuits are associated with depression in PD. However, few studies have been conducted on the circuit-level alterations in this disease...
March 9, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29527489/dynamic-functional-connectivity-in-parkinson-s-disease-patients-with-mild-cognitive-impairment-and-normal-cognition
#11
María Díez-Cirarda, Antonio P Strafella, Jinhee Kim, Javier Peña, Natalia Ojeda, Alberto Cabrera-Zubizarreta, Naroa Ibarretxe-Bilbao
The objective was to assess dynamic functional connectivity (FC) and local/global connectivity in Parkinson's disease (PD) patients with mild cognitive impairment (PD-MCI) and with normal cognition (PD-NC). The sample included 35 PD patients and 26 healthy controls (HC). Cognitive assessment followed an extensive neuropsychological battery. For resting-state functional MRI (rs-fMRI) analysis, independent component analysis (ICA) was performed and components were located in 7 networks: Subcortical (SC), Auditory (AUD), Somatomotor (SM), visual (VI), cognitive-control (CC), default-mode (DMN), and cerebellar (CB)...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29514016/functional-connectivity-of-the-corticobasal-ganglia-thalamocortical-network-in-parkinson-disease-a-systematic-review-and-meta-analysis-with-cross-validation
#12
Gong-Jun Ji, Panpan Hu, Ting-Ting Liu, Ying Li, Xingui Chen, Chunyan Zhu, Yanghua Tian, Xianwen Chen, Kai Wang
Purpose To quantitatively summarize the functional connectivity (FC) feature of the corticobasal ganglia-thalamocortical (CBTC) network in patients with Parkinson disease (PD) by means of a meta-analysis with cross-validation. Materials and Methods For this prospective study, a systematic literature search in the PubMed and EMBASE databases was performed for resting-state functional magnetic resonance (MR) imaging studies of PD published between January 2000 and May 2017. Then, a coordinate-based meta-analysis was conducted by Effect Size-Signed Differential Mapping...
March 7, 2018: Radiology
https://www.readbyqxmd.com/read/29500931/abnormal-resting-state-functional-connectivity-in-posterior-cingulate-cortex-of-parkinson-s-disease-with-mild-cognitive-impairment-and-dementia
#13
Zhou-Wei Zhan, Li-Zhen Lin, Er-Han Yu, Jia-Wei Xin, Lin Lin, Hai-Long Lin, Qin-Yong Ye, Xiao-Chun Chen, Xiao-Dong Pan
OBJECTIVE: To investigate changes in the functional connectivity (FC) pattern in the posterior cingulate cortex (PCC) of Parkinson's disease (PD) patients with mild cognitive impairment and dementia by employing resting-state functional magnetic resonance imaging (RS-fMRI). METHODS: Twenty-seven PD patients with different cognitive status and 9 healthy control subjects (control group) were enrolled for RS-fMRI. The RS-fMRI data were analyzed with DPARSF and REST software...
March 3, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29449186/the-reorganization-of-functional-architecture-in-the-early-stages-of-parkinson-s-disease
#14
Noora Tuovinen, Klaus Seppi, Francesco de Pasquale, Christoph Müller, Michael Nocker, Michael Schocke, Elke R Gizewski, Christian Kremser, Gregor K Wenning, Werner Poewe, Atbin Djamshidian, Christoph Scherfler, Morinobu Seki
INTRODUCTION: The study aim was to identify longitudinal abnormalities of functional connectivity and its relation with motor disability in early to moderately advanced stages of Parkinson's disease patients. METHODS: 3.0T structural and resting-state functional MRI was performed in healthy subjects (n = 16) and Parkinson's disease patients (n = 16) with mean disease duration of 2.2 ± 1.2 years at baseline with a clinical follow-up of 1.5 ± 0...
February 8, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29449183/altered-resting-state-voxel-level-whole-brain-functional-connectivity-in-depressed-parkinson-s-disease
#15
Hansheng Wang, Huiyue Chen, Jiahui Wu, Li Tao, Ya Pang, Min Gu, Fajin Lv, Tianyou Luo, Oumei Cheng, Ke Sheng, Jin Luo, Yida Hu, Weidong Fang
BACKGROUND: Depression is one of the most common non-motor symptoms in Parkinson's disease (PD), but its pathogenesis is still not very clear. Recently, degree centrality, a voxel-level whole-brain functional connectivity (FC) analysis of resting-state functional magnetic resonance imaging, has provided the most promising way to explore the neural network mechanisms underlying depressed PD. METHODS: Degree centrality, voxel-wise image and clinical symptoms correlation and secondary seed-based FC analyses were performed in twenty-seven drug-naïve, early stage depressed PD patients, 27 non-depressed PD patients and 27 healthy controls (HCs) to reveal voxel-level whole-brain FC changes in depressed PD...
February 9, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29448151/functional-cortical-source-connectivity-of-resting-state-electroencephalographic-alpha-rhythms-shows-similar-abnormalities-in-patients-with-mild-cognitive-impairment-due-to-alzheimer-s-and-parkinson-s-diseases
#16
Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Laura Bonanni, Raffaella Franciotti, Marco Onofrj, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia Fraioli, Michela Pievani, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, Erol Başar, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, John Paul Taylor, Maria Francesca De Pandis, Laura Vacca, Giovanni B Frisoni, Fabrizio Stocchi
OBJECTIVE: This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer's (ADMCI) and Parkinson's (PDMCI) diseases compared to healthy elderly subjects (Nold). METHODS: rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N = 75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources...
April 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29408498/dysfunctional-limbic-circuitry-underlying-freezing-of-gait-in-parkinson-s-disease
#17
Moran Gilat, Kaylena A Ehgoetz Martens, Oscar Miranda-Domínguez, Ishu Arpan, James M Shine, Martina Mancini, Damien A Fair, Simon J G Lewis, Fay B Horak
Freezing of gait (FOG) is a poorly understood symptom affecting many patients with Parkinson's disease (PD). Despite growing evidence of a behavioral link between anxiety, attention and FOG in PD, no research to date has investigated the neural mechanisms that might explain this relationship. The present study therefore examined resting-state MRI functional connectivity between the amygdala, striatum and frontoparietal attentional control network in PD patients with (freezers: n = 19) and without FOG (non-freezers: n = 21) in the dopaminergic 'off' state...
March 15, 2018: Neuroscience
https://www.readbyqxmd.com/read/29407464/abnormalities-of-resting-state-functional-cortical-connectivity-in-patients-with-dementia-due-to-alzheimer-s-and-lewy-body-diseases-an-eeg-study
#18
Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Flavio Nobili, Dario Arnaldi, Francesco Famà, Dag Aarsland, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia Fraioli, Michela Pievani, Giovanni B Frisoni, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, Erol Başar, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, Raffaella Franciotti, John Paul Taylor, Laura Vacca, Maria Francesca De Pandis, Laura Bonanni
Previous evidence showed abnormal posterior sources of resting-state delta (<4 Hz) and alpha (8-12 Hz) rhythms in patients with Alzheimer's disease with dementia (ADD), Parkinson's disease with dementia (PDD), and Lewy body dementia (DLB), as cortical neural synchronization markers in quiet wakefulness. Here, we tested the hypothesis of additional abnormalities in functional cortical connectivity computed in those sources, in ADD, considered as a "disconnection cortical syndrome", in comparison with PDD and DLB...
May 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29381889/alteration-in-the-local-and-global-functional-connectivity-of-resting-state-networks-in-parkinson-s-disease
#19
Maryam Ghahremani, Jaejun Yoo, Sun Ju Chung, Kwangsun Yoo, Jong C Ye, Yong Jeong
OBJECTIVE: Parkinson's disease (PD) is a neurodegenerative disorder that mainly leads to the impairment of patients' motor function, as well as of cognition, as it progresses. This study tried to investigate the impact of PD on the resting state functional connectivity of the default mode network (DMN), as well as of the entire brain. METHODS: Sixty patients with PD were included and compared to 60 matched normal control (NC) subjects. For the local connectivity analysis, the resting state fMRI data were analyzed by seed-based correlation analyses, and then a novel persistent homology analysis was implemented to examine the connectivity from a global perspective...
January 2018: Journal of Movement Disorders
https://www.readbyqxmd.com/read/29305892/the-involvement-of-the-pathway-connecting-the-substantia-nigra-the-periaqueductal-gray-matter-and-the-retrotrapezoid-nucleus-in-breathing-control-in-a-rat-model-of-parkinson-s-disease
#20
Juliana C Lima, Luiz M Oliveira, Marina T Botelho, Thiago S Moreira, Ana C Takakura
Parkinson's disease (PD) is characterized by a reduction in the number of dopaminergic neurons of the substantia nigra (SNpc), accompanied by motor and non-motor deficiencies such as respiratory failure. Here, our aim was to investigate possible neuronal communications between the SNpc and chemoreceptor neurons within the retrotrapezoid nucleus (RTN), in order to explain neurodegeneration and the loss of breathing function in the 6-OHDA PD animal model. Male Wistar rats received tracer injections in the SNpc, RTN and periaqueductal gray (PAG) regions to investigate the projections between those regions...
April 2018: Experimental Neurology
keyword
keyword
57360
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"