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Parkinson disease and resting connectivity

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https://www.readbyqxmd.com/read/27911020/changes-in-resting-state-connectivity-in-musicians-with-embouchure-dystonia
#1
Bernhard Haslinger, Jonas Noé, Eckart Altenmüller, Valentin Riedl, Claus Zimmer, Tobias Mantel, Christian Dresel
OBJECTIVE: Embouchure dystonia is a highly disabling task-specific dystonia in professional brass musicians leading to spasms of perioral muscles while playing the instrument. As they are asymptomatic at rest, resting-state functional magnetic resonance imaging in these patients can reveal changes in functional connectivity within and between brain networks independent from dystonic symptoms. METHODS: We therefore compared embouchure dystonia patients to healthy musicians with resting-state functional magnetic resonance imaging in combination with independent component analyses...
December 2, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27896064/executive-attention-networks-show-altered-relationship-with-default-mode-network-in-pd
#2
Peter Boord, Tara M Madhyastha, Mary K Askren, Thomas J Grabowski
Attention dysfunction is a common but often undiagnosed cognitive impairment in Parkinson's disease that significantly reduces quality of life. We sought to increase understanding of the mechanisms underlying attention dysfunction using functional neuroimaging. Functional MRI was acquired at two repeated sessions in the resting state and during the Attention Network Test, for 25 non-demented subjects with Parkinson's disease and 21 healthy controls. Behavioral and MRI contrasts were calculated for alerting, orienting, and executive control components of attention...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27891090/disrupted-nodal-and-hub-organization-account-for-brain-network-abnormalities-in-parkinson-s-disease
#3
Yuko Koshimori, Sang-Soo Cho, Marion Criaud, Leigh Christopher, Mark Jacobs, Christine Ghadery, Sarah Coakeley, Madeleine Harris, Romina Mizrahi, Clement Hamani, Anthony E Lang, Sylvain Houle, Antonio P Strafella
The recent application of graph theory to brain networks promises to shed light on complex diseases such as Parkinson's disease (PD). This study aimed to investigate functional changes in sensorimotor and cognitive networks in Parkinsonian patients, with a focus on inter- and intra-connectivity organization in the disease-associated nodal and hub regions using the graph theoretical analyses. Resting-state functional MRI data of a total of 65 participants, including 23 healthy controls (HCs) and 42 patients, were investigated in 120 nodes for local efficiency, betweenness centrality, and degree...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27871435/resting-state-functional-connectivity-of-subthalamic-nucleus-in-different-parkinson-s-disease-phenotypes
#4
Zhan Wang, Huimin Chen, Huizi Ma, Lingyan Ma, Tao Wu, Tao Feng
Previous studies showed that the subthalamic nucleus (STN) plays a crucial role in Parkinson's disease (PD) pathophysiology. During rest, PD phenotypes exhibit different STN functional connectivity. STN functional connectivity was examined in 31 PD patients [12 tremor-dominant (TD) and 19 posture instability gait difficulty (PIGD)] and 22 healthy controls (HC). Compared with controls and PIGD patients, the TD patients exhibited higher functional connectivity between the bilateral STN and the left cerebellar anterior lobe...
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27859903/corticostriatal-connectivity-fingerprints-probability-maps-based-on-resting-state-functional-connectivity
#5
Ellen Jaspers, Joshua H Balsters, Pegah Kassraian Fard, Dante Mantini, Nicole Wenderoth
Over the last decade, structure-function relationships have begun to encompass networks of brain areas rather than individual structures. For example, corticostriatal circuits have been associated with sensorimotor, limbic, and cognitive information processing, and damage to these circuits has been shown to produce unique behavioral outcomes in Autism, Parkinson's Disease, Schizophrenia and healthy ageing. However, it remains an open question how abnormal or absent connectivity can be detected at the individual level...
November 12, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27848084/default-mode-network-connectivity-in-cognitively-unimpaired-drug-na%C3%A3-ve-patients-with-rigidity-dominant-parkinson-s-disease
#6
Yanbing Hou, Chunyan Luo, Jing Yang, Ruwei Ou, Wanglin Liu, Wei Song, Qiyong Gong, Huifang Shang
Parkinson's disease (PD) with akinetic rigidity (PDAR) is more likely to develop cognitive deficits compared to PD with tremor-dominant symptoms (PDTD). The default mode network (DMN) is highly relevant for cognitive processes, so this study tested the functional connectivity (FC) of DMN in cognitively unimpaired PDAR patients. Resting-state fMRI data were collected in 21 cognitively unimpaired early stage drug-naïve patients with PDAR and 21 healthy controls (HC). PD patients were matched closely to HCs for demographic and cognitive variables...
November 15, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27833548/dysfunction-of-the-default-mode-network-in-drug-na%C3%A3-ve-parkinson-s-disease-with-mild-cognitive-impairments-a-resting-state-fmri-study
#7
Yanbing Hou, Jing Yang, Chunyan Luo, Wei Song, Ruwei Ou, Wanglin Liu, Qiyong Gong, Huifang Shang
Objective: Cognitive impairments are common in Parkinson's disease (PD) and can even occur in the early stages. The default mode network (DMN) is highly relevant for cognitive processes; however, it remains largely unknown if changes in the DMN connectivity are related to the cognitive decline in drug-naïve early stage PD patients with a mild cognitive impairment (MCI). This study used resting-state functional MRI (fMRI) to explore the brain connectivity of the DMN in early stage drug-naïve PD patients with MCI...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27788143/brain-connectivity-changes-in-autosomal-recessive-parkinson-disease-a-model-for-the-sporadic-form
#8
Elena Makovac, Mara Cercignani, Laura Serra, Mario Torso, Barbara Spanò, Simona Petrucci, Lucia Ricciardi, Monia Ginevrino, Carlo Caltagirone, Anna Rita Bentivoglio, Enza Maria Valente, Marco Bozzali
Biallelic genetic mutations in the Park2 and PINK1 genes are frequent causes of autosomal recessive PD. Carriers of single heterozygous mutations may manifest subtle signs of disease, thus providing a unique model of preclinical PD. One emerging hypothesis suggests that non-motor symptom of PD, such as cognitive impairment may be due to a distributed functional disruption of various neuronal circuits. Using resting-state functional MRI (RS-fMRI), we tested the hypothesis that abnormal connectivity within and between brain networks may account for the patients' cognitive status...
2016: PloS One
https://www.readbyqxmd.com/read/27771933/deguelin-and-its-role-in-chronic-diseases
#9
Jonathan Boyd, Alice Han
Deguelin is one of four major naturally occurring rotenoids isolated from root extracts and is best recognized as a NADH: ubiquinone oxidoreductase (complex I) inhibitor, resulting in significant alterations in mitochondrial function. Deguelin has also been implicated as a regulator of apoptosis through signaling pathways, such as the (PI3K)/Akt pathway, as well as an initiator of cell cycle arrest. Consequently, this compound has accrued great interest as a potential chemopreventive and chemotherapeutic. Additionally, deguelin exposure has been linked to Parkinson's disease (PD)...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27757820/increased-brain-connectivity-and-activation-after-cognitive-rehabilitation-in-parkinson-s-disease-a-randomized-controlled-trial
#10
María Díez-Cirarda, Natalia Ojeda, Javier Peña, Alberto Cabrera-Zubizarreta, Olaia Lucas-Jiménez, Juan Carlos Gómez-Esteban, Maria Ángeles Gómez-Beldarrain, Naroa Ibarretxe-Bilbao
Cognitive rehabilitation programs have demonstrated efficacy in improving cognitive functions in Parkinson's disease (PD), but little is known about cerebral changes associated with an integrative cognitive rehabilitation in PD. To assess structural and functional cerebral changes in PD patients, after attending a three-month integrative cognitive rehabilitation program (REHACOP). Forty-four PD patients were randomly divided into REHACOP group (cognitive rehabilitation) and a control group (occupational therapy)...
October 18, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27717835/a-resting-state-fmri-study-on-early-stage-drug-na%C3%A3-ve-parkinson-s-disease-patients-with-drooling
#11
Yanbing Hou, Chunyan Luo, Jing Yang, Wei Song, Ruwei Ou, Wanglin Liu, Qiyong Gong, Huifang Shang
OBJECTIVE: Drooling is a common symptom in Parkinson's disease (PD). This study used resting-state functional MRI (fMRI) to evaluate the brain connectivity of cortico-striatal circuits in PD patients with drooling. METHOD: We enrolled 30 early-stage drug-naïve PD patients and 30 matched normal controls. Among the PD patients, 15 patients were classified as "droolers" with the presence of drooling and 15 patients as "non-droolers" with the absence of drooling. All participants underwent resting-state fMRI scans on a 3-T MR system, focusing on the functional connectivity of striatum subregions...
October 4, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27704616/anatomical-and-functional-correlates-of-persistent-pain-in-parkinson-s-disease
#12
Andrea Polli, Luca Weis, Roberta Biundo, Michael Thacker, Andrea Turolla, Kostantinos Koutsikos, K Ray Chaudhuri, Angelo Antonini
BACKGROUND: The pathophysiology of pain in Parkinson's disease (PD) is still poorly understood, although it is conceivable that supraspinal mechanisms may be responsible for pain generation and maintenance. METHODS: We examined brain functional and anatomical changes associated with persistent pain in 40 PD patients, 20 with persistent pain and 20 without pain. We also examined 15 pain-free healthy participants of similar age, gender, and cognitive state as a control group...
October 5, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27704282/climbing-fiber-purkinje-cell-synaptic-pathology-in-tremor-and-cerebellar-degenerative-diseases
#13
Sheng-Han Kuo, Chi-Ying Lin, Jie Wang, Peter A Sims, Ming-Kai Pan, Jyun-You Liou, Danielle Lee, William J Tate, Geoffrey C Kelly, Elan D Louis, Phyllis L Faust
Changes in climbing fiber-Purkinje cell (CF-PC) synaptic connections have been found in the essential tremor (ET) cerebellum, and these changes are correlated with tremor severity. Whether these postmortem changes are specific to ET remains to be investigated. We assessed CF-PC synaptic pathology in the postmortem cerebellum across a range of degenerative movement disorders [10 Parkinson's disease (PD) cases, 10 multiple system atrophy (MSA) cases, 10 spinocerebellar ataxia type 1 (SCA1) cases, and 20 ET cases] and 25 controls...
October 4, 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27663605/levodopa-effect-on-basal-ganglia-motor-circuit-in-parkinson-s-disease
#14
Lin-Lin Gao, Jiarong Zhang, Piu Chan, Tao Wu
AIMS: To investigate the effects of levodopa on the basal ganglia motor circuit (BGMC) in Parkinson's disease (PD). METHODS: Thirty PD patients with asymmetrical bradykinesia and 30 control subjects were scanned using resting-state functional MRI. Functional connectivity of the BGMC was measured and compared before and after levodopa administration in patients with PD. The correlation between improvements in bradykinesia and changes in BGMC connectivity was examined...
September 24, 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27659747/altered-functional-connectivity-in-the-default-mode-network-is-associated-with-cognitive-impairment-and-brain-anatomical-changes-in-parkinson-s-disease
#15
Olaia Lucas-Jiménez, Natalia Ojeda, Javier Peña, María Díez-Cirarda, Alberto Cabrera-Zubizarreta, Juan Carlos Gómez-Esteban, María Ángeles Gómez-Beldarrain, Naroa Ibarretxe-Bilbao
OBJECTIVE: To assess whether functional neural connectivity is disrupted between the regions of the default mode network (DMN) in Parkinson's disease (PD) and how this connectivity is related to cognition, brain gray matter structure and white matter integrity and diffusivity. METHODS: Thirty-seven PD patients and 16 healthy controls were evaluated, using resting-state functional magnetic resonance imaging (MRI), T1-weighted MRI, diffusion-weighted imaging and a battery of cognitive tests...
September 10, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27616476/improving-and-accelerating-the-differentiation-and-functional-maturation-of-human-stem-cell-derived-neurons-role-of-extracellular-calcium-and-gaba
#16
Paul J Kemp, David J Rushton, Polina L Yarova, Christian Schnell, Charlene Geater, Jane M Hancock, Annalena Wieland, Alis Hughes, Luned Badder, Emma Cope, Daniela Riccardi, Andrew D Randall, Jonathan T Brown, Nicholas D Allen, Vsevolod Telezhkin
Neurons differentiated from pluripotent stem cells using established neural culture conditions often exhibit functional deficits. Recently, we have developed enhanced media which both synchronize the neurogenesis of pluripotent stem cell-derived neural progenitors and accelerate their functional maturation; together these media are termed SynaptoJuice. This pair of media are pro-synaptogenic and generate authentic, mature synaptic networks of connected forebrain neurons from a variety of induced pluripotent and embryonic stem cell lines...
November 15, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27611959/altered-resting-state-functional-connectivity-of-the-striatum-in-parkinson-s-disease-after-levodopa-administration
#17
Wanqun Yang, Bin Liu, Biao Huang, Ruiwang Huang, Lijuan Wang, Yuhu Zhang, Xiong Zhang, Kai Wu
BACKGROUND: Despite improvement in motor symptoms, the effect of dopaminergic medications on cognition in patients with Parkinson's disease (PD) is less clear. The purpose of this study was to reveal levodopa-induced acute changes in the functional connectivity of the striatum in patients with PD compared with matched untreated patients and healthy volunteers. METHODS: Twenty-two patients with PD underwent functional magnetic resonance imaging both ON and OFF dopamine-replacement therapy on two consecutive days...
2016: PloS One
https://www.readbyqxmd.com/read/27568202/connectivity-changes-in-parkinson-s-disease
#18
REVIEW
Antonio Cerasa, Fabiana Novellino, Aldo Quattrone
Parkinson's disease (PD) is a chronic and progressive movement disorder of the central nervous system characterized by widespread alterations in several non-motor aspects such as mood, sleep, olfactory, and cognition in addition to motor dysfunctions. Advanced neuroimaging using functional connectivity reconstruction of the human brain has provided a vast knowledge on the pathophysiological mechanisms underlying this disorder, but this, however, does not cover the overall inter-/intra-individual variability of PD phenotypes...
October 2016: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/27497913/parkinson-s-disease-autoimmunity-and-neuroinflammation
#19
REVIEW
Armando De Virgilio, Antonio Greco, Giovanni Fabbrini, Maurizio Inghilleri, Maria Ida Rizzo, Andrea Gallo, Michela Conte, Chiara Rosato, Mario Ciniglio Appiani, Marco de Vincentiis
Parkinson's disease is a neurodegenerative disease that causes the death of dopaminergic neurons in the substantia nigra. The resulting dopamine deficiency in the basal ganglia leads to a movement disorder that is characterized by classical parkinsonian motor symptoms. Parkinson's disease is recognized as the most common neurodegenerative disorder after Alzheimer's disease. PD ethiopathogenesis remains to be elucidated and has been connected to genetic, environmental and immunologic conditions. The past decade has provided evidence for a significant role of the immune system in PD pathogenesis, either through inflammation or an autoimmune response...
October 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27472694/altered-directional-connectivity-between-emotion-network-and-motor-network-in-parkinson-s-disease-with-depression
#20
Peipeng Liang, Gopikrishna Deshpande, Sinan Zhao, Jiangtao Liu, Xiaoping Hu, Kuncheng Li
Depression is common in patients with Parkinson's disease (PD), which can make all the other symptoms of PD much worse. It is thus urgent to differentiate depressed PD (DPD) patients from non-depressed PD (NDPD).The purpose of the present study was to characterize alterations in directional brain connectivity unique to Parkinson's disease with depression, using resting state functional magnetic resonance imaging (rs-fMRI).Sixteen DPD patients, 20 NDPD patients, 17 patients with major depressive disorder (MDD) and 21 healthy control subjects (normal controls [NC]) underwent structural MRI and rs-fMRI scanning...
July 2016: Medicine (Baltimore)
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