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Parkinson disease and resting connectivity

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https://www.readbyqxmd.com/read/29305892/the-involvement-of-the-pathway-connecting-the-substantia-nigra-the-periaqueductal-gray-matter-and-the-retrotrapezoid-nucleus-in-breathing-control-in-a-rat-model-of-parkinson-s-disease
#1
Juliana C Lima, Luiz M Oliveira, Marina T Botelho, Thiago S Moreira, Ana C Takakura
Parkinson's disease (PD) is characterized by a reduction in the number of dopaminergic neurons of the substantia nigra (SNpc), accompanied by motor and non-motor deficiencies such as respiratory failure. Here, our aim was to investigate possible neuronal communications between the SNpc and chemoreceptor neurons within the retrotrapezoid nucleus (RTN), in order to explain neurodegeneration and the loss of breathing function in the 6-OHDA PD animal model. Male Wistar rats received tracer injections in the SNpc, RTN and periaqueductal gray (PAG) regions to investigate the projections between those regions...
January 4, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29304050/severe-hyposmia-and-aberrant-functional-connectivity-in-cognitively-normal-parkinson-s-disease
#2
Noritaka Yoneyama, Hirohisa Watanabe, Kazuya Kawabata, Epifanio Bagarinao, Kazuhiro Hara, Takashi Tsuboi, Yasuhiro Tanaka, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Tatsuya Hattori, Mizuki Ito, Naoki Atsuta, Tomohiko Nakamura, Masaaki Hirayama, Satoshi Maesawa, Masahisa Katsuno, Gen Sobue
OBJECTIVE: Severe hyposmia is a risk factor of dementia in Parkinson's disease (PD), while the underlying functional connectivity (FC) and brain volume alterations in PD patients with severe hyposmia (PD-SH) are unclear. METHODS: We examined voxel-based morphometric and resting state functional magnetic resonance imaging findings in 15 cognitively normal PD-SH, 15 cognitively normal patients with PD with no/mild hyposmia (PD-N/MH), and 15 healthy controls (HCs)...
2018: PloS One
https://www.readbyqxmd.com/read/29230170/the-dancing-brain-structural-and-functional-signatures-of-expert-dance-training
#3
Agnieszka Z Burzynska, Karolina Finc, Brittany K Taylor, Anya M Knecht, Arthur F Kramer
Dance - as a ritual, therapy, and leisure activity - has been known for thousands of years. Today, dance is increasingly used as therapy for cognitive and neurological disorders such as dementia and Parkinson's disease. Surprisingly, the effects of dance training on the healthy young brain are not well understood despite the necessity of such information for planning successful clinical interventions. Therefore, this study examined actively performing, expert-level trained college students as a model of long-term exposure to dance training...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29222835/effective-network-of-deep-brain-stimulation-of-subthalamic-nucleus-with-bimodal-positron-emission-tomography-functional-magnetic-resonance-imaging-in-parkinson-s-disease
#4
Hui-Min Chen, Zhi-Qiang Sha, Hui-Zi Ma, Yong He, Tao Feng
AIMS: Deep brain stimulation of the subthalamic nucleus (STN-DBS) has become an effective treatment strategy for patients with Parkinson's disease. However, the biological mechanism underlying DBS treatment remains poorly understood. METHOD: In this study, we investigated how STN-DBS modulated the brain network using a bimodal positron emission tomography (PET)/functional magnetic resonance imaging (fMRI) dataset. We first performed an activation likelihood estimation meta-analysis of 13 PET/SPECT studies concerning STN-DBS effects on resting-state brain activity in Parkinson's disease...
December 8, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29193464/functional-connectivity-in-dementia-with-lewy-bodies-a-within-and-between-network-analysis
#5
Julia Schumacher, Luis R Peraza, Michael Firbank, Alan J Thomas, Marcus Kaiser, Peter Gallagher, John T O'Brien, Andrew M Blamire, John-Paul Taylor
Dementia with Lewy bodies (DLB) is a common form of dementia and is characterized by cognitive fluctuations, visual hallucinations, and Parkinsonism. The phenotypic expression of the disease may, in part, relate to alterations in functional connectivity within and between brain networks. This resting-state study sought to clarify this in DLB, how networks differed from Alzheimer's disease (AD), and whether they were related to clinical symptoms in DLB. Resting-state networks were estimated using independent component analysis...
November 29, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29182621/exploring-the-reproducibility-of-functional-connectivity-alterations-in-parkinson-s-disease
#6
Liviu Badea, Mihaela Onu, Tao Wu, Adina Roceanu, Ovidiu Bajenaru
Since anatomic MRI is presently not able to directly discern neuronal loss in Parkinson's Disease (PD), studying the associated functional connectivity (FC) changes seems a promising approach toward developing non-invasive and non-radioactive neuroimaging markers for this disease. While several groups have reported such FC changes in PD, there are also significant discrepancies between studies. Investigating the reproducibility of PD-related FC changes on independent datasets is therefore of crucial importance...
2017: PloS One
https://www.readbyqxmd.com/read/29163072/altered-functional-brain-connectomes-between-sporadic-and-familial-parkinson-s-patients
#7
Yan Tang, Xue Xiao, Hua Xie, Chang-Min Wan, Li Meng, Zhen-Hua Liu, Wei-Hua Liao, Bei-Sha Tang, Ji-Feng Guo
Familial Parkinson's disease (PD) is often caused by mutation of a certain gene, while sporadic PD is associated with variants of genes which can influence the susceptibility to PD. The goal of this study was to investigate the difference between the two forms of PD in terms of brain abnormalities using resting-state functional MRI and graph theory. Thirty-one familial PD patients and 36 sporadic PD patients underwent resting-state functional MRI scanning. Frequency-dependent functional connectivity was calculated for each subject using wavelet-based correlations of BOLD signal over 246 brain regions from Brainnetome Atlas...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29113397/altered-putamen-functional-connectivity-is-associated-with-anxiety-disorder-in-parkinson-s-disease
#8
Xixi Wang, Junyi Li, Yongsheng Yuan, Min Wang, Jian Ding, Jiejin Zhang, Lin Zhu, Yuting Shen, Hui Zhang, Kezhong Zhang
In this study, we used resting state-functional magnetic resonance imaging (rs-fMRI) to explore altered putamen functional connectivity (FC) in Parkinson's disease patients with anxiety disorder. We divided 65 Parkinson's disease patients into anxiety (PD-A; n=18) and non-anxiety (PD-NA; n=45) groups based on a Hamilton Anxiety Rating Scale cutoff score of 12. The PD-A patients exhibited altered putamen FC with cortical and subcortical regions. The PD-A patients showed enhanced putamen FC with the caudatum, which correlated with increased emotional processing during anxiety...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29065697/altered-functional-connectivity-between-precuneus-and-motor-systems-in-parkinson-s-disease-patients
#9
Raissa Benocci Thibes, Natalia P Novaes, Leandro T Lucato, Kenia R Campanholo, Luciano M Melo, Claudia C Leite, Edson Amaro, Egberto Reis Barbosa, Edson Bor-Seng-Shu, Ellison Fernando Cardoso, João Ricardo Sato
INTRODUCTION: Parkinson's Disease (PD) is a neurodegenerative disorder that affects motor skills and cognition. As brain structure and function are compromised, functional magnetic resonance imaging (fMRI) can be a helpful tool to further investigate how intrinsic connectivity is impaired on the disease. The precuneus and medial prefrontal cortex are hub regions involved on the Default Mode Network, a system which is active during rest and related to cognitive processes. We hypothesized that PD patients would present a decrease in functional connectivity amongst these two regions and the rest of the brain...
October 25, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/29053835/abnormal-intrinsic-brain-functional-network-dynamics-in-parkinson-s-disease
#10
Jinhee Kim, Marion Criaud, Sang Soo Cho, María Díez-Cirarda, Alexander Mihaescu, Sarah Coakeley, Christine Ghadery, Mikaeel Valli, Mark F Jacobs, Sylvain Houle, Antonio P Strafella
No abstract text is available yet for this article.
November 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28971008/distinct-alterations-in-parkinson-s-medication-state-and-disease-state-connectivity
#11
Bernard Ng, Gael Varoquaux, Jean Baptiste Poline, Bertrand Thirion, Michael D Greicius, Kathleen L Poston
Altered brain connectivity has been described in people with Parkinson's disease and in response to dopaminergic medications. However, it is unclear whether dopaminergic medications primarily 'normalize' disease related connectivity changes or if they induce unique alterations in brain connectivity. Further, it is unclear how these disease- and medication-associated changes in brain connectivity relate differently to specific motor manifestations of disease, such as bradykinesia/rigidity and tremor. In this study, we applied a novel covariance projection approach in combination with a bootstrapped permutation test to resting state functional MRI data from 57 Parkinson's disease and 20 healthy control participants to determine the Parkinson's medication-state and disease-state connectivity changes associated with different motor manifestations of disease...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28970788/altered-functional-connectivity-density-in-subtypes-of-parkinson-s-disease
#12
Xiaofei Hu, Yuchao Jiang, Xiaomei Jiang, Jiuquan Zhang, Minglong Liang, Jing Li, Yanling Zhang, Dezhong Yao, Cheng Luo, Jian Wang
Parkinson's disease (PD) can be classified into tremor-dominant and akinetic-rigid subtypes, each of which exhibits a unique clinical course and prognosis. The neural basis for these disparate manifestations is not well-understood, however. This study comprehensively investigated the altered functional connectivity patterns of these two subtypes. Twenty-five tremor-dominant patients, 25 akinetic-rigid patients and 26 normal control subjects participated in this study. Resting-state functional MRI data were analyzed using functional connectivity density (FCD) and seed-based functional connectivity approaches...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28952907/loss-of-functional-connectivity-in-patients-with-parkinson-disease-and-visual-hallucinations
#13
Dagmar H Hepp, Elisabeth M J Foncke, Kim T E Olde Dubbelink, Wilma D J van de Berg, Henk W Berendse, Menno M Schoonheim
Purpose To gain more insight into the pathophysiological mechanisms of visual hallucinations (VHs) in patients with Parkinson disease (PD) by analyzing whole-brain resting-state functional connectivity in PD patients with VH (hereafter, referred to as PD + VH patients) and without VH (hereafter, referred to as PD - VH patients) and control participants. Materials and Methods For this retrospective study, 15 PD + VH patients, 40 PD - VH patients, and 15 control participants from a prospective cohort study were included, which was approved by the local ethics board and written informed consent was obtained from all participants...
December 2017: Radiology
https://www.readbyqxmd.com/read/28949049/intrinsic-brain-connectivity-predicts-impulse-control-disorders-in-patients-with-parkinson-s-disease
#14
Alessandro Tessitore, Rosa De Micco, Alfonso Giordano, Federica di Nardo, Giuseppina Caiazzo, Mattia Siciliano, Manuela De Stefano, Antonio Russo, Fabrizio Esposito, Gioacchino Tedeschi
BACKGROUND: Impulse control disorders can be triggered by dopamine replacement therapies in patients with PD. Using resting-state functional MRI, we investigated the intrinsic brain network connectivity at baseline in a cohort of drug-naive PD patients who successively developed impulse control disorders over a 36-month follow-up period compared with patients who did not. METHODS: Baseline 3-Tesla MRI images of 30 drug-naive PD patients and 20 matched healthy controls were analyzed...
December 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28942477/cognitive-performance-in-mid-stage-parkinson-s-disease-functional-connectivity-under-chronic-antiparkinson-treatment
#15
Roxana Vancea, Kristina Simonyan, Maria Petracca, Miroslaw Brys, Alessandro Di Rocco, Maria Felice Ghilardi, Matilde Inglese
Cognitive impairment in Parkinson's disease (PD) is related to the reorganization of brain topology. Although drug challenge studies have proven how levodopa treatment can modulate functional connectivity in brain circuits, the role of chronic dopaminergic therapy on cognitive status and functional connectivity has never been investigated. We sought to characterize brain functional topology in mid-stage PD patients under chronic antiparkinson treatment and explore the presence of correlation between reorganization of brain architecture and specific cognitive deficits...
September 23, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28940855/long-term-effects-of-cognitive-rehabilitation-on-brain-functional-outcome-and-cognition-in-parkinson-s-disease
#16
María Díez-Cirarda, Natalia Ojeda, Javier Peña, Alberto Cabrera-Zubizarreta, Olaia Lucas-Jiménez, Juan Carlos Gómez-Esteban, Maria Ángeles Gómez-Beldarrain, Naroa Ibarretxe-Bilbao
BACKGROUND: Cognitive rehabilitation has demonstrated efficacy in producing short-term cognitive and brain changes in Parkinson's disease (PD) patients. To date, no study has assessed the long-term effects of cognitive rehabilitation using neuroimaging techniques in PD. The aim was to assess the longitudinal effects of a 3-month cognitive rehabilitation program evaluating the cognitive, behavioural and neuroimaging changes after 18 months. METHODS: Fifteen PD patients underwent a cognitive, behavioural and neuroimaging assessment at pre-treatment (T0 ), post-treatment (T1 ) and after 18-months (T2 )...
September 23, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28939804/separate-neural-representations-of-depression-anxiety-and-apathy-in-parkinson-s-disease
#17
Rotem Dan, Filip Růžička, Ondrej Bezdicek, Evžen Růžička, Jan Roth, Josef Vymazal, Gadi Goelman, Robert Jech
Depression, anxiety and apathy are distinct neuropsychiatric symptoms that highly overlap in Parkinson's disease (PD). It remains unknown whether each symptom is uniquely associated with a functional network dysfunction. Here, we examined whether individual differences in each neuropsychiatric symptom predict functional connectivity patterns in PD patients while controlling for all other symptoms and motor function. Resting-state functional connectivity MRI were acquired from 27 PD patients and 29 healthy controls...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28898869/disrupted-brain-network-hubs-in-subtype-specific-parkinson-s-disease
#18
Ling-Yan Ma, Xiao-Dan Chen, Yong He, Hui-Zi Ma, Tao Feng
BACKGROUND/AIMS: The topological organization of brain functional networks is impaired in Parkinson's disease (PD). However, the altered patterns of functional network hubs in different subtypes of PD are not completely understood. METHODS: 3T resting-state functional MRI and voxel-based graph-theory analysis were employed to systematically investigate the intrinsic functional connectivity patterns of whole-brain networks. We enrolled 31 patients with PD (12 tremor dominant [TD] and 19 with postural instability/gait difficulty [PIGD]) and 22 matched healthy controls...
2017: European Neurology
https://www.readbyqxmd.com/read/28876500/on-the-integrity-of-functional-brain-networks-in-schizophrenia-parkinson-s-disease-and-advanced-age-evidence-from-connectivity-based-single-subject-classification
#19
Rachel N Pläschke, Edna C Cieslik, Veronika I Müller, Felix Hoffstaedter, Anna Plachti, Deepthi P Varikuti, Mareike Goosses, Anne Latz, Svenja Caspers, Christiane Jockwitz, Susanne Moebus, Oliver Gruber, Claudia R Eickhoff, Kathrin Reetz, Julia Heller, Martin Südmeyer, Christian Mathys, Julian Caspers, Christian Grefkes, Tobias Kalenscher, Robert Langner, Simon B Eickhoff
Previous whole-brain functional connectivity studies achieved successful classifications of patients and healthy controls but only offered limited specificity as to affected brain systems. Here, we examined whether the connectivity patterns of functional systems affected in schizophrenia (SCZ), Parkinson's disease (PD), or normal aging equally translate into high classification accuracies for these conditions. We compared classification performance between pre-defined networks for each group and, for any given network, between groups...
September 6, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28860987/apathy-in-patients-with-parkinson-s-disease-correlates-with-alteration-of-left-fronto-polar-electroencephalographic-connectivity
#20
Florian Hatz, Antonia Meyer, Ronan Zimmermann, Ute Gschwandtner, Peter Fuhr
Introduction: Quantitative electroencephalography (QEEG) brain frequency and network analyses are known to differentiate between disease stages in Parkinson's disease (PD) and are possible biomarkers. They correlate with cognitive decline. Little is known about changes in brain networks in relation to apathy. Objective/Aims: To analyze changes in brain network connectivities related to apathy. Methods: 40 PD patients (14 PD with mild cognitive deficits and 26 PD with normal cognition) were included. All patients had extensive neuropsychological testing; apathy was evaluated using the apathy evaluation score (AES, median 24...
2017: Frontiers in Aging Neuroscience
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