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Parkinson disease and resting connectivity

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https://www.readbyqxmd.com/read/28769862/correlation-between-dopamine-transporter-degradation-and-striatocortical-network-alteration-in-parkinson-s-disease
#1
Wei-Che Lin, Hsiu-Ling Chen, Tun-Wei Hsu, Chien-Chin Hsu, Yung-Cheng Huang, Nai-Wen Tsai, Cheng-Hsien Lu
The association between dopamine neuron loss and functional change in the striatocortical network was analyzed in 31 patients with Parkinson's disease (PD) [mean disease duration 4.03 ± 4.20 years; Hoehn and Yahr (HY) stage 2.2 ± 1.2] and 37 age-matched normal control subjects. We performed (99m)Tc-TRODAT-1 SPECT/CT imaging to detect neuron losses and resting-state functional magnetic resonance imaging to detect functional changes. Mean striatal dopamine transporter binding ratios were determined by region of interest analysis...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28763447/braph-a-graph-theory-software-for-the-analysis-of-brain-connectivity
#2
Mite Mijalkov, Ehsan Kakaei, Joana B Pereira, Eric Westman, Giovanni Volpe
The brain is a large-scale complex network whose workings rely on the interaction between its various regions. In the past few years, the organization of the human brain network has been studied extensively using concepts from graph theory, where the brain is represented as a set of nodes connected by edges. This representation of the brain as a connectome can be used to assess important measures that reflect its topological architecture. We have developed a freeware MatLab-based software (BRAPH-BRain Analysis using graPH theory) for connectivity analysis of brain networks derived from structural magnetic resonance imaging (MRI), functional MRI (fMRI), positron emission tomography (PET) and electroencephalogram (EEG) data...
2017: PloS One
https://www.readbyqxmd.com/read/28727571/altered-putamen-functional-connectivity-is-associated-with-anxiety-disorder-in-parkinson-s-disease
#3
Xixi Wang, Junyi Li, Yongsheng Yuan, Min Wang, Jian Ding, Jiejin Zhang, Lin Zhu, Yuting Shen, Hui Zhang, Kezhong Zhang
In this study, we used resting state-functional magnetic resonance imaging (rs-fMRI) to explore altered putamen functional connectivity (FC) in Parkinson's disease patients with anxiety disorder. We divided 65 Parkinson's disease patients into anxiety (PD-A; n=18) and non-anxiety (PD-NA; n=45) groups based on a Hamilton Anxiety Rating Scale cutoff score of 12. The PD-A patients exhibited altered putamen FC with cortical and subcortical regions. The PD-A patients showed enhanced putamen FC with the caudatum, which correlated with increased emotional processing during anxiety...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28715675/resting-state-brain-networks-in-patients-with-parkinson-s-disease-and-impulse-control-disorders
#4
Alessandro Tessitore, Gabriella Santangelo, Rosa De Micco, Alfonso Giordano, Simona Raimo, Marianna Amboni, Fabrizio Esposito, Paolo Barone, Gioacchino Tedeschi, Carmine Vitale
INTRODUCTION: To investigate intrinsic neural networks connectivity changes in Parkinson's disease (PD) patients with and without impulse control disorders (ICD). METHODS: Fifteen patients with PD with ICD (ICD+), 15 patients with PD without ICD (ICD-) and 24 age and sex-matched healthy controls (HC) were enrolled in the study. To identify patients with and without ICD and/or punding, we used the Minnesota Impulsive Disorders Interview (MIDI) and a clinical interview based on diagnostic criteria for each symptom...
June 24, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28687605/alterations-in-functional-cortical-hierarchy-in-hemiparkinsonian-rats
#5
B N Jávor-Duray, M Vinck, M van der Roest, E Bezard, H W Berendse, T Boraud, P Voorn
Parkinson's disease and experimentally induced hemiparkinsonism are characterized by increased beta-synchronization between cortical and subcortical areas. This change in beta-connectivity might reflect either a symmetric increase in interareal influences or asymmetric changes in directed influences among brain areas. We assessed patterns of functional and directed connectivity within and between striatum and six cortical sites in each hemisphere of the hemiparkinsonian rat model. Local field potentials were recorded in resting and walking states, before and after unilateral 6-hydroxydopamine lesion...
July 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28675834/effects-of-levodopa-on-corticostriatal-circuits-supporting-working-memory-in-parkinson-s-disease
#6
Alison C Simioni, Alain Dagher, Lesley K Fellows
Working memory dysfunction is common in Parkinson's disease, even in its early stages, but its neural basis is debated. Working memory performance likely reflects a balance between corticostriatal dysfunction and compensatory mechanisms. We tested this hypothesis by examining working memory performance with a letter n-back task in 19 patients with mild-moderate Parkinson's disease and 20 demographically matched healthy controls. Parkinson's disease patients were tested after an overnight washout of their usual dopamine replacement therapy, and again after a standard dose of levodopa...
August 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28674492/aberrant-intrinsic-activity-and-connectivity-in-cognitively-normal-parkinson-s-disease
#7
Deborah L Harrington, Qian Shen, Gabriel N Castillo, J Vincent Filoteo, Irene Litvan, Colleen Takahashi, Chelsea French
Disturbances in intrinsic activity during resting-state functional MRI (rsfMRI) are common in Parkinson's disease (PD), but have largely been studied in a priori defined subnetworks. The cognitive significance of abnormal intrinsic activity is also poorly understood, as are abnormalities that precede the onset of mild cognitive impairment. To address these limitations, we leveraged three different analytic approaches to identify disturbances in rsfMRI metrics in 31 cognitively normal PD patients (PD-CN) and 30 healthy adults...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28668411/functional-and-structural-changes-in-gray-matter-of-parkinson-s-disease-patients-with-mild-cognitive-impairment
#8
Boyu Chen, Shanshan Wang, Wenge Sun, Xiuli Shang, Hu Liu, Guohao Liu, Jie Gao, Guoguang Fan
BACKGROUND AND PURPOSE: Cognitive impairment is a common non-motor complication of Parkinson's disease (PD). To investigate cognitive-related changes of gray matter (GM) structure and function in PD using voxel-based morphometry (VBM) and resting state functional connectivity (RSFC). MATERIALS AND METHODS: Resting state functional magnetic resonance imaging (rs-fMRI) and 3D-T1-weighted MRI scans were obtained from 21 PD patients with mild cognitive impairment (PD-MCI), 11 PD patients with normal cognitive function (PD-NC), and 21 healthy controls (HC)...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28652595/altered-brain-metabolic-connectivity-at-multiscale-level-in-early-parkinson-s-disease
#9
Arianna Sala, Silvia Paola Caminiti, Luca Presotto, Enrico Premi, Andrea Pilotto, Rosanna Turrone, Maura Cosseddu, Antonella Alberici, Barbara Paghera, Barbara Borroni, Alessandro Padovani, Daniela Perani
To explore the effects of PD pathology on brain connectivity, we characterized with an emergent computational approach the brain metabolic connectome using [18F]FDG-PET in early idiopathic PD patients. We applied whole-brain and pathology-based connectivity analyses, using sparse-inverse covariance estimation in thirty-four cognitively normal PD cases and thirty-four age-matched healthy subjects for comparisons. Further, we assessed high-order resting state networks by interregional correlation analysis. Whole-brain analysis revealed altered metabolic connectivity in PD, with local decreases in frontolateral cortex and cerebellum and increases in the basal ganglia...
June 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28611616/differential-functional-connectivity-alterations-of-two-subdivisions-within-the-right-dlpfc-in-parkinson-s-disease
#10
Julian Caspers, Christian Mathys, Felix Hoffstaedter, Martin Südmeyer, Edna C Cieslik, Christian Rubbert, Christian J Hartmann, Claudia R Eickhoff, Kathrin Reetz, Christian Grefkes, Jochen Michely, Bernd Turowski, Alfons Schnitzler, Simon B Eickhoff
Patients suffering from Parkinson's disease (PD) often show impairments in executive function (EF) like decision-making and action control. The right dorsolateral prefrontal cortex (dlPFC) has been strongly implicated in EF in healthy subjects and has repeatedly been reported to show alterations related to EF impairment in PD. Recently, two key regions for cognitive action control have been identified within the right dlPFC by co-activation based parcellation. While the posterior region is engaged in rather basal EF like stimulus integration and working memory, the anterior region has a more abstract, supervisory function...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28597560/l-dopa-responsiveness-is-associated-with-distinctive-connectivity-patterns-in-advanced-parkinson-s-disease
#11
Harith Akram, Chengyuan Wu, Jonathan Hyam, Thomas Foltynie, Patricia Limousin, Enrico De Vita, Tarek Yousry, Marjan Jahanshahi, Marwan Hariz, Timothy Behrens, John Ashburner, Ludvic Zrinzo
BACKGROUND: Neuronal loss and dopamine depletion alter motor signal processing between cortical motor areas, basal ganglia, and the thalamus, resulting in the motor manifestations of Parkinson's disease. Dopamine replacement therapy can reverse these manifestations with varying degrees of improvement. METHODS: To evaluate functional connectivity in patients with advanced Parkinson's disease and changes in functional connectivity in relation to the degree of response to l-dopa, 19 patients with advanced Parkinson's disease underwent resting-state functional magnetic resonance imaging in the on-medication state...
June 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28588475/distinct-role-of-striatal-functional-connectivity-and-dopaminergic-loss-in-parkinson-s-symptoms
#12
Juergen Dukart, Fabio Sambataro, Alessandro Bertolino
Degeneration of dopaminergic neurons is a hallmark of Parkinson's disease. However, its link to Parkinson's disease symptoms remains unclear. Striatal resting state functional connectivity differentiates between Parkinson's disease patients and healthy controls and might be a potential mediator of the effects of striatal dopaminergic degeneration onto Parkinson's disease symptoms. Here, we evaluated the relationship between dopaminergic deficits, striatal functional connectivity (SFC) at rest and different Parkinson's disease clinical symptoms in the largest currently established cohort of de novo Parkinson's disease patients...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28586141/connectivity-predicts-deep-brain-stimulation-outcome-in-parkinson-disease
#13
Andreas Horn, Martin Reich, Johannes Vorwerk, Ningfei Li, Gregor Wenzel, Qianqian Fang, Tanja Schmitz-Hübsch, Robert Nickl, Andreas Kupsch, Jens Volkmann, Andrea A Kühn, Michael D Fox
OBJECTIVE: The benefit of deep brain stimulation (DBS) for Parkinson disease (PD) may depend on connectivity between the stimulation site and other brain regions, but which regions and whether connectivity can predict outcome in patients remain unknown. Here, we identify the structural and functional connectivity profile of effective DBS to the subthalamic nucleus (STN) and test its ability to predict outcome in an independent cohort. METHODS: A training dataset of 51 PD patients with STN DBS was combined with publicly available human connectome data (diffusion tractography and resting state functional connectivity) to identify connections reliably associated with clinical improvement (motor score of the Unified Parkinson Disease Rating Scale [UPDRS])...
July 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28566724/aberrant-intra-and-internetwork-functional-connectivity-in-depressed-parkinson-s-disease
#14
Luqing Wei, Xiao Hu, Yajing Zhu, Yonggui Yuan, Weiguo Liu, Hong Chen
Much is known concerning the underlying mechanisms of Parkinson's disease (PD) with depression, but our understanding of this disease at the neural-system level remains incomplete. This study used resting-state functional MRI (rs-fMRI) and independent component analysis (ICA) to investigate intrinsic functional connectivity (FC) within and between large-scale neural networks in 20 depressed PD (dPD) patients, 35 non-depressed PD (ndPD) patients, and 34 healthy controls (HC). To alleviate the influence caused by ICA model order selection, this work reported results from analyses at 2 levels (low and high model order)...
May 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28558317/changes-in-resting-state-directed-connectivity-in-cortico-subcortical-networks-correlate-with-cognitive-function-in-parkinson-s-disease
#15
Lennard I Boon, Arjan Hillebrand, Kim T E Olde Dubbelink, Cornelis J Stam, Henk W Berendse
OBJECTIVE: The pathophysiological mechanisms underlying Parkinson's disease (PD)-related cognitive decline and conversion to PD dementia are poorly understood. In the healthy human brain, stable patterns of posterior-to-anterior cortical information flow have recently been demonstrated in the higher frequency bands using magnetoencephalography (MEG). In this study we estimated PD-related changes in information flow patterns, as well as the contribution of subcortical regions. METHODS: Resting-state MEG recordings were acquired in moderately advanced PD patients (n=34; mean Hoehn and Yahr-stage 2...
July 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28539629/early-onset-mild-cognitive-impairment-in-parkinson-s-disease-altered-corticopetal-cholinergic-network
#16
Injoong Kim, Na-Young Shin, Yunjin Bak, Phil Hyu Lee, Seung-Koo Lee, Soo Mee Lim
Degeneration of the substantia innominata (SI) is significantly correlated with cognitive performance in Parkinson's disease (PD). We examined functional and structural patterns of SI degeneration in drug-naïve PD patients according to the duration of parkinsonism before mild cognitive impairment (MCI) diagnosis. Twenty PD patients with a shorter duration (PD-MCI-SD, <1 year), 18 patients with a longer duration (PD-MCI-LD, ≥1 year), and 29 patients with intact cognition (PD-IC) were included. Seed-based resting-state functional connectivity (rsFC) analysis using bilateral SI seed and region-of-interest-based volumetric analysis were performed...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28490656/role-of-habenula-and-amygdala-dysfunction-in-parkinson-disease-patients-with-punding
#17
Vladana Markovic, Federica Agosta, Elisa Canu, Alberto Inuggi, Igor Petrovic, Iva Stankovic, Francesca Imperiale, Tanja Stojkovic, Vladimir S Kostic, Massimo Filippi
OBJECTIVE: To assess whether a functional dysregulation of the habenula and amygdala, as modulators of the reward brain circuit, contributes to Parkinson disease (PD) punding. METHODS: Structural and resting-state functional MRI were obtained from 22 patients with PD punding, 30 patients with PD without any impulsive-compulsive behavior (ICB) matched for disease stage and duration, motor impairment, and cognitive status, and 30 healthy controls. Resting-state functional connectivity of the habenula and amygdala bilaterally was assessed using a seed-based approach...
June 6, 2017: Neurology
https://www.readbyqxmd.com/read/28467917/resting-state-functional-reorganization-in-parkinson-s-disease-an-activation-likelihood-estimation-meta-analysis
#18
REVIEW
Masoud Tahmasian, Simon B Eickhoff, Kathrin Giehl, Frank Schwartz, Damian M Herz, Alexander Drzezga, Thilo van Eimeren, Angela R Laird, Peter T Fox, Habibolah Khazaie, Mojtaba Zarei, Carsten Eggers, Claudia R Eickhoff
Parkinson's disease (PD) is a common progressive neurodegenerative disorder. Studies using resting-state functional magnetic resonance imaging (fMRI) to investigate underlying pathophysiology of motor and non-motor symptoms in PD yielded largely inconsistent results. This quantitative neuroimaging meta-analysis aims to identify consistent abnormal intrinsic functional patterns in PD across studies. We used PubMed to retrieve suitable resting-state studies and stereotactic data were extracted from 28 individual between-group comparisons...
April 8, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28462585/pramipexole-modulates-interregional-connectivity-within-the-sensorimotor-network
#19
Zheng Ye, Anke Hammer, Thomas F Münte
Pramipexole is widely prescribed to treat Parkinson's disease but has been reported to cause impulse control disorders such as pathological gambling. Recent neurocomputational models suggested that D2 agonists may distort functional connections between the striatum and the motor cortex, resulting in impaired reinforcement learning and pathological gambling. To examine how D2 agonists modulate the striatal-motor connectivity, we carried out a pharmacological resting-state functional magnetic resonance imaging study with a double-blind randomized within-subject crossover design...
May 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28431177/altered-functional-connectivity-in-idiopathic-rapid-eye-movement-sleep-behavior-disorder-a-resting-state-eeg-study
#20
Jun-Sang Sunwoo, Sanghun Lee, Jung-Hoon Kim, Jung-Ah Lim, Tae-Joon Kim, Jung-Ick Byun, Min Hee Jeong, Kwang Su Cha, Jeong Woo Choi, Kyung Hwan Kim, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Kon Chu, Manho Kim, Sang Kun Lee, Ki-Young Jung
Study Objectives: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is considered as a prodromal stage of synucleinopathy. Although loss of functional connectivity is implicated in neurodegenerative diseases, network characteristics of electroencephalography (EEG) in iRBD are unknown. Therefore, we evaluated resting-state EEG functional connectivity to identify the brain network changes in patients with iRBD. Methods: We prospectively enrolled 20 patients with polysomnography-confirmed iRBD and 16 controls...
June 1, 2017: Sleep
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