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alpha 1 microglobin

Yu Wu, Tao Su, Li Yang, Sai-Nan Zhu, Xiao-Mei Li
INTRODUCTION: The role of urinary biomarkers of kidney injury in the prediction of adverse clinical outcomes in drug-induced chronic tubulointerstitial nephritis (D-CTIN) has not been well described. METHODS: A total of 36 patients with D-CTIN were enrolled in the study. The baseline urinary excretion of neutrophil gelatinase-associated lipocalin (NGAL), alpha1-microglobin (alpha1-MG), albumin (mAlb) and total protein were measured, and estimated glomerular filtration rate change rates within a period of 6 to 33 (mean: 24 months) follow-up months were recorded...
June 2010: American Journal of the Medical Sciences
Xiao-yun Luo, Qing-hua Wu, Zhong Chen, Jun Ma, Yan-min Han, Xiao-bin Tang, Zhang-min Wu, Lei Kou, Hui Liu, Qing Li, Yun-feng Jia, Zhen Zhang, Nan He
OBJECTIVES: To investigate differential expression of plasma proteins of patients with Takayasu's arteritis to screen disease-related or phase-related proteins or biomarkers. METHODS: From March, 2005 to January, 2006, Plasma of 20 patients with acute Takayasu's arteritis, 20 patients with chronic Takayasu's arteritis, and 20 healthy people as control were collected. Plasma proteins were profiled by two-dimensional electrophoresis. Spots of differential expression were screened by computerized map analysis and identified by matrix assisted laser desorption/ionization time of flight-mass spectrometry...
January 19, 2010: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Jun Ma, Xiaoyun Luo, Qinghua Wu, Zhong Chen, Lei Kou, Haitao Wang
OBJECTIVE: Takayasu arteritis (TA) is an immune-mediated disease with an unknown etiology. Assessment of disease activity in patients with TA is challenging owing to the absence of reliable serologic markers. Because circulation levels of acute-phase proteins fluctuate with the severity and extent of the inflammatory reaction, they may be potential biomarkers for the identification of TA activity. To test this hypothesis, certain acute-phase proteins were examined in TA patients and controls...
March 2010: Journal of Vascular Surgery
S Sadeghi-Bojd, M Hashemi, M Karimi
INTRODUCTION: In patients with beta-thalassaemia major, impaired biosynthesis of the beta-globin leads to accumulation of unpaired alpha-globin chain. Shortened red cell lifespan and iron overload cause functional and physiological abnormalities in various organ systems. Thus, in patients with beta-thalassaemia major, the most important cause of mortality and morbidity is organ failure due to deposits of iron. The aim of this study is to investigate renal tubular and glomerular functions in patients with beta-thalassaemia major...
May 2008: Singapore Medical Journal
Jian-kang Zhang, Long-feng Zhao, Jun Cheng, Jiang Guo, Yong-zhi Lun, Yuan Hong
BACKGROUND: The hepatitis B virus (HBV) genome includes S, C, P and X regions. The S region is divided into four subregions of pre-pre-S, pre-S1, pre-S2 and S. PS1TP5 (human gene 5 transactivated by pre-S1 protein of HBV) is a novel target gene transactivated by the pre-S1 protein that has been screened with a suppression subtractive hybridization technique in our laboratory (GenBank accession: AY427953). In order to investigate the biological function of the PS1TP5 protein, we performed a yeast two-hybrid system 3 to screen proteins from a human leukocyte cDNA library interacting with the PS1TP5 protein...
November 20, 2006: Chinese Medical Journal
R Ohno, Y Yamaguchi, T Toge, T Kinouchi, T Kotake, M Shibata, Y Kiyohara, S Ikeda, I Fukui, A Gohchi, Y Sugiyama, S Saji, S Hazama, M Oka, K Ohnishi, Y Ohhashi, S Tsukagoshi, T Taguchi
A pilot dose-escalation study of recombinant human interleukin 12 (rhIL-12) was conducted in Japanese patients with advanced malignancies. Cohorts of three patients received escalating doses of rhIL-12 that increased from 50 to 300 ng/kg/day s.c. three times a week for 2 weeks followed by 1-week rest. The same dosage and schedule was repeated for two additional courses. Sixteen previously treated patients were registered, and 15 were evaluated. Common toxicities were fever and leukopenia; the abnormality of laboratory tests included elevations in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, C-reactive protein, and beta2-microglobin...
July 2000: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
A Takatsu
Sudden unexpected natural death (SUND) has several characteristics, such as unknown clinical history, very short course to death, evidence of trauma, interference of postmortem changes and social implications of diagnosis. From these points, SUND involves important challenges in forensic pathology. Presented here are the highlights of our SUND studies which allow scientific speculation into the antemortem pathophysiological course to death and a subsequent accurate diagnosis of the cause of death in SUND cases...
December 1995: Nihon Hōigaku Zasshi, the Japanese Journal of Legal Medicine
F Krull, G Ziemer, I Luhmer, J H Ehrich, R G Galaske, H C Kallfelz
We investigated early postoperative renal function in 55 consecutive infants who underwent cardiac surgery in deep hypothermic circulatory arrest (DHCA). In 15 of these patients detailed studies of glomerular and tubular function of the kidneys were performed. Mean time of circulatory arrest at 20 degrees Celsius rectal temperature was 53 +/- 15 minutes. Acute renal failure was seen in four patients due to cardiogenic shock from which they died on the second and third postoperative day. Urine flow in the surviving 51 infants ranged from 120 to 150 ml/h/1...
November 1988: Monatsschrift Kinderheilkunde: Organ der Deutschen Gesellschaft Für Kinderheilkunde
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