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Contrast-induced nephropathy

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https://www.readbyqxmd.com/read/29150416/-bicarbonate-from-physiology-to-treatment-for-all-clinicians
#1
Julie Beaume, Antoine Braconnier, Thibault Dolley-Hitze, Jean-Philippe Bertocchio
Acid-base regulation is essential to maintain homeostasis in humans. Carbonic acid/bicarbonate (H2CO3/HCO3(-)) couple is the most predominant extracellular buffer to keep plasma pH within a physiological range. The ability to (re)generate such a buffer is a key milestone that necessitates to understand a precise physiology of both renal tubule and digestive tract. Here, we first reviewed renal and digestive cycles of bicarbonate in physiology. We also reviewed pathological findings where acid-base disequilibrium is involved and nutritional and/or alkali therapy could be necessary...
November 14, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29148243/are-new-devices-required-to-reduce-contrast-load-in-the-cath-lab-or-is-behavioral-change-sufficient
#2
EDITORIAL
Toby Rogers, Lowell F Satler
A novel device that diverts a proportion of contrast injected by hand through the manifold can potentially reduce volume of contrast delivered to the patient by almost 50% to reduce risk of contrast-induced nephropathy. Another simple solution to reducing contrast volume is to limit the number of angiographic views and cine runs acquired. A conscious effort by the angiographer to limit the contrast volume to less than the eGFR should be considered.
November 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29141361/-effect-of-probucol-on-preventing-contrast-induced-nephropathy-in-patients-undergoing-percutaneous-coronary-intervention
#3
X Q Suo, S C Yang, Z H Ma, T T Sun, W Y Zhang, H L Cong, W H Lin, C Z Lu, F S Tian, N K Fu
Objective: To investigate the preventive effect, possible mechanism and safety of probucol on contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD). Methods: A total of 641 patients with coronary heart disease were consecutively enrolled from Department of Cardiology, in Tianjin Chest Hospital, Tianjin TEDA International Cardiovascular Hospital, Tianjin First Central Hospital, Tianjin Fourth Central Hospital. They were randomly divided into probucol group (n=321) and control group (n=320)...
November 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29123405/contrast-media-induced-nephropathy-how-has-italy-contributed-in-the-past-30-years-a-systematic-review
#4
REVIEW
Maurizio Sessa, Claudia Rossi, Annamaria Mascolo, Cristina Scavone, Gabriella di Mauro, Roberto Grassi, Liberata Sportiello, Salvatore Cappabianca, Concetta Rafaniello
Background and objective: The use of contrast media in Italy has exponentially increased in the past 3 decades. However, it is unknown whether there has been an increase in clinical research evaluating the risks associated with contrast media usage, especially regarding contrast-induced nephropathy. To fill this gap in knowledge, we performed a systematic review. Study eligibility criteria: Meta-analyses, observational studies, and clinical trials assessing contrast media-induced nephropathy as the safety outcome, in which at least one author was affiliated with an Italian university/health care structure, were eligble...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29120880/culprit-versus-multivessel-coronary-intervention-in-st-segment-elevation-myocardial-infarction-a-meta-analysis-of-randomized-trials
#5
Satyanarayana R Vaidya, Arman Qamar, Sameer Arora, Santhosh R Devarapally, Ashok Kondur, Prashant Kaul
BACKGROUND: The 2015 American College of Cardiology/American Heart Association update on primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) recommended PCI of the non-infarct-related artery at the time of primary PCI (class IIb recommendation). Despite evidence supporting complete revascularization in STEMI, its benefit on mortality rates is uncertain. METHODS: We searched all available databases for randomized controlled trials comparing complete multivessel percutaneous coronary intervention (CMV PCI) with infarct-artery-only revascularization in patients with STEMI...
November 8, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29118770/contrast-induced-nephropathy-is-less-common-in-patients-with-good-coronary-collateral-circulation
#6
Eyup Avci, Tarik Yildirim, Hasan Kadi
Background/Aims: Contrast-induced nephropathy (CIN) is a typically reversible type of acute renal failure that develops after exposure to contrast agents; underlying endothelial dysfunction is thought to be an important risk factor for CIN. Although the mechanism of coronary collateral circulation (CCC) is not fully understood, a pivotal role of the endothelium has been reported in many studies. The aim of this study was to investigate whether there is a relationship between CCC and CIN...
October 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29111980/impact-of-continuation-of-metformin-prior-to-elective-coronary-angiography-on-acute-contrast-nephropathy-in-patients-with-normal-or-mildly-impaired-renal-functions
#7
Veysel Oktay, İlknur Calpar Çıralı, Ümit Yaşar Sinan, Ahmet Yıldız, Murat Kazım Ersanlı
OBJECTIVE: Discontinuation of metformin treatment in patients scheduled for elective coronary angiography (CAG) is controversial because of post-procedural risks including acute contrast-induced nephropathy (CIN) and lactic acidosis (LA). This study aims to discuss the safety of continuing metformin treatment in patients undergoing elective CAG with normal or mildly impaired renal functions. METHODS: Our study was designed as a single-centered, randomized, and observational study including 268 patients undergoing elective CAG with an estimated glomerular filtration rate of >60 mL/min/1...
October 31, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29106836/impact-of-transient-or-persistent-contrast-induced-nephropathy-on-long-term-mortality-after-elective-percutaneous-coronary-intervention
#8
Mitsuru Abe, Takeshi Morimoto, Yoshihisa Nakagawa, Yutaka Furukawa, Koh Ono, Takao Kato, Kazushige Kadota, Kenji Ando, Mitsuru Ishii, Nobutoyo Masunaga, Masaharu Akao, Takeshi Kimura
Contrast-induced nephropathy (CIN) is associated with increased long-term mortality. However, it is still controversial whether CIN is the cause of increased mortality or merely a marker of high-risk patients. The current study population included 5,516 patients who underwent their first elective percutaneous coronary intervention (PCI) in the Coronary REvascularization Demonstrating Outcome Study in Kyoto registry cohort-2. CIN was defined as an elevation in the peak serum creatinine (SCr) of ≥0.5 mg/dl from the baseline within 5 days after PCI...
September 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29102563/tgf-%C3%AE-mediates-renal-fibrosis-via-the-smad3-erbb4-ir-long-noncoding-rna-axis
#9
Min Feng, Patrick Ming-Kuen Tang, Xiao-Ru Huang, Si-Fan Sun, Yong-Ke You, Jun Xiao, Lin-Li Lv, An-Ping Xu, Hui-Yao Lan
Transforming growth factor β (TGF-β)/Smad3 signaling plays a role in tissue fibrosis. We report here that Erbb4-IR is a novel long non-coding RNA (lncRNA) responsible for TGF-β/Smad3-mediated renal fibrosis and is a specific therapeutic target for chronic kidney disease. Erbb4-IR was induced by TGF-β1 via a Smad3-dependent mechanism and was highly upregulated in the fibrotic kidney of mouse unilateral ureteral obstructive nephropathy (UUO). Silencing Erbb4-IR blocked TGF-β1-induced collagen I and alpha-smooth muscle actin (α-SMA) expressions in vitro and effectively attenuated renal fibrosis in the UUO kidney by blocking TGF-β/Smad3 signaling...
October 5, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29097928/assessing-the-risk-of-contrast-induced-nephropathy-using-a-finger-stick-analysis-in-recalls-from-breast-screening-the-cinfibs-explorative-study
#10
I P L Houben, C J L Y van Berlo, O Bekers, E C Nijssen, M B I Lobbes, J E Wildberger
Purpose: To evaluate whether a handheld point-of-care (POC) device is able to predict and discriminate patients at potential risk of contrast-induced nephropathy (CIN) prior to iodine-based contrast media delivery. Methods and Materials: Between December 2014 and June 2016, women undergoing contrast-enhanced spectral mammography (CESM) with an iodine-based contrast agent were asked to have their risk of CIN assessed by a dedicated POC device (StatSensor CREAT) and a risk factor questionnaire based on national guidelines...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29089038/the-impact-of-n-acetylcysteine-and-ascorbic-acid-in-contrast-induced-nephropathy-in-critical-care-patients-an-open-label-randomized-controlled-study
#11
Eleni Palli, Demosthenes Makris, John Papanikolaou, Grigorios Garoufalis, Irini Tsilioni, Paris Zygoulis, Epaminondas Zakynthinos
BACKGROUND: The aim was to investigate whether the use of N-acetylcysteine and ascorbic acid reduce contrast-induced nephropathy incidence in critical care patients. METHODS: This was a one-center, two-arm, prospective, randomized, open-label, controlled trial in the Intensive Care Unit of the University Hospital of Larissa, Greece. Patients with stable renal function, who underwent non urgent contrast-enhanced computed tomography for diagnostic purposes, were included in the study...
October 31, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29073785/preventive-effects-of-alprostadil-against-contrast-induced-nephropathy-inpatients-with-renal-insufficiency-undergoing-percutaneous-coronary-intervention
#12
Shi-Cheng Yang, Nai-Kuan Fu, Jing Zhang, Min Liang, Hong-Liang Cong, Wen-Hua Lin, Feng-Shi Tian, Cheng-Zhi Lu, Ting-Ting Sun, Wen-Ya Zhang, Zhen-Hua Ma
We investigated the preventive effect of alprostadil on contrast-induced nephropathy (CIN) in patients with renal insufficiency undergoing percutaneous coronary intervention (PCI). A total of 300 patients with creatinine clearance (crCl) ≤60 mL/min undergoing PCI were randomly assigned to alprostadil or a control group. The primary end point was the incidence of CIN defined as an increase in serum creatinine (Scr) levels by ≥0.5 mg/dL or≥ 25% after administration of the contrast media within 72 hours...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/29071556/the-efficacy-of-probucol-combined-with-hydration-in-preventing-contrast-induced-nephropathy-in-patients-with-coronary-heart-disease-undergoing-percutaneous-coronary-intervention-a-multicenter-prospective-randomized-controlled-study
#13
Naikuan Fu, Shicheng Yang, Jing Zhang, Peng Zhang, Min Liang, Hongliang Cong, Wenhua Lin, Fengshi Tian, Chengzhi Lu
PURPOSE: To investigate the preventive effect of probucol combined with hydration on contrast-induced nephropathy (CIN) in patients with coronary heart disease undergoing percutaneous coronary intervention (PCI). METHODS: A total of 641 patients undergoing PCI were randomly assigned to either a probucol group (probucol 500 mg twice daily and hydration; n = 321) or a control group (hydration only; n = 320). The primary endpoint was the incidence of CIN, defined as an increase in serum creatinine (Scr) by ≥ 44...
October 25, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29064276/predictors-of-acute-kidney-injury-in-patients-admitted-with-st-elevation-myocardial-infarction-results-from-the-bremen-stemi-registry
#14
Johannes Schmucker, Andreas Fach, Matthias Becker, Susanne Seide, Stefanie Bünger, Robert Zabrocki, Eduard Fiehn, Bettina Würmann-Busch, Hermann Pohlabeln, Kathrin Günther, Wolfgang Ahrens, Rainer Hambrecht, Harm Wienbergen
BACKGROUND: Deterioration of renal function after exposition to contrast media is a common problem in patients with myocardial infarction undergoing percutaneous coronary interventions. The aim of the present study was to assess the incidence of acute kidney injury in patients admitted with ST-elevation-myocardial infarction (STEMI) and its association with infarction severity, comorbidities and treatment modalities, including amount of contrast media applied. METHODS: All patients with STEMI from the metropolitan area of Bremen, Germany are treated at the Bremen Heart Centre and since 2006 documented in the Bremen STEMI-Registry...
June 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29039485/calcium-dobesilate-may-alleviate-diabetes%C3%A2-induced-endothelial-dysfunction-and-inflammation
#15
Yijun Zhou, Jiangzi Yuan, Chaojun Qi, Xinghua Shao, Shan Mou, Zhaohui Ni
Diabetic kidney disease (DKD) is a leading cause of end‑stage renal disease. However, the pathogenesis of DKD remains unclear, and no effective treatments for the disease are available. Thus, there is an urgent need to elucidate the pathogenic mechanisms of DKD and to develop more effective therapies for this disease. Human umbilical vein endothelial cells (HUVECs) were cultured using different D‑glucose concentrations to determine the effect of high glucose (HG) on the cells. Alternatively, HUVECs were incubated with 100 µmol/l calcium dobesilate (CaD) to detect its effects...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29038896/inducible-atf3-nfat-axis-aggravates-podocyte-injury
#16
Hong Zhang, Shun Liang, Yue Du, Ruizhao Li, Chaosheng He, Wenjian Wang, Shuangxin Liu, Zhiming Ye, Xinling Liang, Wei Shi, Bin Zhang
Podocyte injury and loss contribute to proteinuria, glomerulosclerosis, and eventually kidney failure. Activating transcription factor 3 (ATF3) is a stress inducible transcription factor that is transiently expressed following stimulation. However, we show for the first time an induction of ATF3 in podocytes from patients with chronic kidney disease, including minimal change disease, focal segmental glomerulosclerosis, and diabetic nephropathy. The role of ATF3 induction in podocytes under chronic conditions is currently unknown...
October 16, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29035878/resveratrol-ameliorates-contrast-induced-nephropathy-through-the-activation-of-sirt1-pgc-1%C3%AE-foxo1-signaling-in-mice
#17
Yu Ah Hong, So Yeon Bae, Shin Young Ahn, Jieun Kim, Young Joo Kwon, Woon Yong Jung, Gang Jee Ko
BACKGROUND/AIMS: SIRT1 activation promotes the resistance of renal tubular cells to oxidative stress, and resveratrol is known as a SIRT1 activator. METHODS: Resveratrol was injected intraperitoneally with iohexol for 24 hours. NRK-52E cells were pretreated with resveratrol for 24 hours and then exposed to iohexol for 3 hours. Renal function was measured by serum creatinine and cell survival was assessed by MTT assay. We investigated whether resveratrol attenuates oxidative stress and apoptosis in contrast-induced nephropathy (CIN)...
October 13, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29033366/the-bermuda-triangle-chronic-kidney-disease-contrast-induced-nephropathy-and-atrial-fibrillation
#18
Ahmed Shawky Elserafy
No abstract text is available yet for this article.
September 1, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29024304/efficacy-of-alprostadil-in-preventing-contrast-induced-nephropathy-in-patients-undergoing-percutaneous-coronary-intervention-a-multicenter-prospective-randomized-controlled-trial
#19
Min Liang, Shicheng Yang, Naikuan Fu, Chengzhi Lu, Fengshi Tian, Xiaochun Xing, Wenhua Lin, Jingjing Liu
BACKGROUND: The role of alprostadil on the prevention of contrast-induced nephropathy (CIN) still remains controversial. The purpose of this study was to examine the effects of short-term alprostadil on the incidence of CIN in patients undergoing elective percutaneous coronary intervention (PCI). METHODS: A total of 480 patients with coronary heart disease undergoing PCI were enrolled in our study and randomly assigned to two groups. The control group (n = 240) was given only hydration therapy and the alprostadil group (n = 240) received intravenous administration of 20 ug/day (diluted with 100 ml normal saline) from 0...
October 10, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28986810/recent-advances-in-chinese-medicine-for-contrast-induced-nephropathy
#20
Xue-Zhong Gong
No abstract text is available yet for this article.
October 6, 2017: Chinese Journal of Integrative Medicine
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