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https://www.readbyqxmd.com/read/29029138/the-female-genital-tract-microbiome-is-associated-with-vaginal-antiretroviral-drug-concentrations-in-human-immunodeficiency-virus-infected-women-on-antiretroviral-therapy
#1
Renee Donahue Carlson, Anandi N Sheth, Timothy D Read, Michael B Frisch, C Christina Mehta, Amy Martin, Richard E Haaland, Anar S Patel, Chou-Pong Pau, Colleen S Kraft, Igho Ofotokun
Background: The female genital tract (FGT) microbiome may affect vaginal pH and other factors that influence drug movement into the vagina. We examined the relationship between the microbiome and antiretroviral concentrations in the FGT. Methods: Over one menstrual cycle, 20 human immunodeficiency virus (HIV)-infected women virologically suppressed on tenofovir (TFV) disoproxil fumarate/emtricitabine and ritonavir-boosted atazanavir (ATV) underwent serial paired cervicovaginal and plasma sampling for antiretroviral concentrations using high-performance liquid chromatography-tandem mass spectrometry...
October 5, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029020/the-endometrial-polarity-paradox-differential-regulation-of-polarity-within-secretory-phase-human-endometrium
#2
Sarah Whitby, Lois A Salamonsen, Jemma Evans
A major cause of infertility in normal and assisted reproduction cycles is failure of the endometrium to undergo appropriate changes during the secretory phase of the menstrual cycle as it acquires receptivity for an implanting blastocyst. Current dogma states that loss of epithelial polarity in the luminal epithelial cells, the point of first contact between maternal endometrium and blastocyst, may facilitate embryo implantation. Loss of polarity is likely an important change during the secretory phase to overcome mutual repulsion between otherwise polarised epithelial surfaces...
September 29, 2017: Endocrinology
https://www.readbyqxmd.com/read/29026748/knowledge-and-awareness-regarding-menstruation-and-hiv-aids-among-schoolgoing-adolescent-girls
#3
Rakhi Jain, Puneet Anand, Anuj Dhyani, Deshant Bansal
INTRODUCTION: Menstruation in our country is associated with various myths and restrictions leading to lack of awareness among adolescent girls. Insufficient menstrual hygiene practices are the cause of stress associated with menstruation and reproductive tract infections. Sexually transmitted infections and HIV/AIDS are not openly discussed in our society making adolescents vulnerable to them. AIM: To assess the knowledge of school going adolescent girls regarding menstrual hygiene and HIV/AIDS...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29026436/relationship-between-menstruation-status-and-work-conditions-in-japan
#4
Mariko Nishikitani, Mutsuhiro Nakao, Shinobu Tsurugano, Mariko Inoure, Eiji Yano
BACKGROUND: Menstrual problems can significantly impact daily and work life. In reaction to a shrinking population, the Japanese government is encouraging more women to participate in the labor force. Actual success in achieving this aim, however, is limited. Specifically, participation in the workforce by women during their reproductive years is impacted by their health, which involves not only work conditions, but also traditional family circumstances. Therefore, it is important to further assess and gather more information about the health status of women who work during their reproductive years in Japan...
2017: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/29025102/effects-of-non-cavity-distorting-fibroids-on-endometrial-gene-expression-and-function
#5
L Aghajanova, S Houshdaran, J C Irwin, L C Giudice
Uterine fibroids are a common finding in infertility patients. Impaired implantation and decidualization have been proposed to contribute to compromised fertility. Data are limited on the endometrial transcriptome from subjects with uterine fibroids, as well as endometrial receptivity and decidualization potential of endometrial stromal fibroblasts (eSF) from women with fibroids. Our objective was to investigate the endometrial transcriptome of women with non-cavity distorting intramural fibroids and compare them to control subjects with no uterine pathology throughout the menstrual cycle...
August 30, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29024986/stromal-fibroblasts-from-perimenopausal-endometrium-exhibit-a-different-transcriptome-than-those-from-the-premenopausal-endometrium
#6
David W Erikson, Fatima Barragan, Terhi T Piltonen, Joseph C Chen, Shaina Balayan, Juan C Irwin, Linda C Giudice
Human endometrium undergoes extensive regeneration on a cyclic basis in premenopausal women and likely occurs through the contribution of stem/progenitor cells. Menopause results in the permanent cessation of menstrual cycles and is preceded by perimenopause, a period of several years in which endocrine and biological changes occur and is a period of risk for endometrial proliferative disorders. The objectives of this study were to identify mesenchymal stem cells (eMSC) and stromal fibroblasts (eSF) in endometrium of perimenopausal women and perform expression profile analysis of perimenopausal eMSC and eSF to gain insight into the biology of stem/progenitor and lineage cell populations during the transition to menopause...
August 19, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29024378/the-cyclocalyx-study-ovulatory-cycle-affects-circulating-compartments-of-the-endothelial-glycocalyx-in-blood
#7
Nikolai Hulde, Nina Rogenhofer, Florian Brettner, Nicole C Eckert, Isabella Götzfried, Thu Nguyen, Judith-I Pagel, Tobias Kammerer, Klaus F Hofmann-Kiefer, Gustav Schelling, Andreas Dendorfer, Markus Rehm, Christian J Thaler
PROBLEM: The endothelial glycocalyx (EGX) plays an important role in vascular integrity. Recently, increased levels of EGX components were detected in the circulating blood of healthy pregnant women and were related to the increased tendency to edema formation during gestation. However, the EGX has not yet been systematically studied in non-pregnant women during ovulatory cycles. METHOD OF STUDY: Serum levels of EGX components syndecan-1, heparan sulfate, and hyaluronan in healthy women (n = 16) at 3 phases of the ovulatory cycle (early follicular phase, at ovulation, and mid-luteal phase) were compared with a control group of healthy men (n = 10)...
October 11, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29023494/pooled-analysis-of-menstrual-irregularities-from-three-major-clinical-studies-evaluating-everolimus-for-the-treatment-of-tuberous-sclerosis-complex
#8
Steven Sparagana, David N Franz, Darcy A Krueger, John J Bissler, Noah Berkowitz, Karin Burock, J Christopher Kingswood
OBJECTIVES: To determine the impact of everolimus on female fertility, including menstrual irregularities, secondary amenorrhea, and luteinizing and follicle stimulating hormone levels in female patients. DESIGN: A pooled analysis from 3 prospective studies consisting of a core phase (≥6 months) and a long-term follow-up open-label extension. SETTING: One phase 2 single-center and two phase 3 multicenter studies. PARTICIPANTS: Data were obtained from female participants, restricted to those between 10 and 55 years of age, during 1 of 3 of the described clinical trials of everolimus...
2017: PloS One
https://www.readbyqxmd.com/read/29023359/menstrual-disruption-with-exercise-is-not-linked-to-an-energy-availability-threshold
#9
Jay L Lieberman, Mary Jane De Souza, David A Wagstaff, Nancy I Williams
INTRODUCTION: Chronic reductions in energy availability (EA) suppress reproductive function. A particular calculation of EA quantifies the dietary energy remaining after exercise for all physiological functions. Reductions in LH pulse frequency have been demonstrated when EA using this calculation is < 30 kcal/ kg ffm·d. PURPOSE: We determined whether menstrual disturbances (MD) are induced when EA is < 30 kcal/ kg ffm·d. METHODS: Thirty-five sedentary, ovulatory women 18-24 yr (weight= 59...
October 10, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29022209/therapeutic-doses-of-doxorubicin-induce-premature-senescence-of-human-mesenchymal-stem-cells-derived-from-menstrual-blood-bone-marrow-and-adipose-tissue
#10
Irina Kozhukharova, Victoria Zemelko, Zoya Kovaleva, Larisa Alekseenko, Olga Lyublinskaya, Nikolay Nikolsky
Doxorubicin (Dox) is an effective anticancer drug with known activity against a wide spectrum of malignancies, hematologic malignancies in particular. Despite extensive clinical use, the mechanisms of its side effects and negative action on normal cells remain under study. The aim of this study was to investigate the effect of Dox on cultured human mesenchymal stem cells (MSCs) derived from menstrual blood (eMSCs), bone marrow (BMSCs) and adipose tissue (AMSCs). Dox treatment in high doses decreased the survival of MSCs in a dose-dependent manner...
October 11, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29021546/functional-maturation-in-preterm-infants-measured-by-serial-recording-of-cortical-activity
#11
N J Stevenson, L Oberdorfer, N Koolen, J M O'Toole, T Werther, K Klebermass-Schrehof, S Vanhatalo
Minimally invasive, automated cot-side tools for monitoring early neurological development can be used to guide individual treatment and benchmark novel interventional studies. We develop an automated estimate of the EEG maturational age (EMA) for application to serial recordings in preterm infants. The EMA estimate was based on a combination of 23 computational features estimated from both the full EEG recording and a period of low EEG activity (46 features in total). The combination function (support vector regression) was trained using 101 serial EEG recordings from 39 preterm infants with a gestational age less than 28 weeks and normal neurodevelopmental outcome at 12 months of age...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29020784/-screening-of-endometrial-nk-cells-in-selected-infertile-patients-first-part-methods-and-current-results
#12
Z Ulčová-Gallová, M Pešek, P Chaloupka, P Mukešnábl, M Haschová, P Losan, K Bibková, Z Mičanová, J Cibulka
INTRODUCTION: Generaly, natural killer cells (NK cells) are among the most important cells of our immune defense system. They are present in the blood, decidua but also in secretory endometrium. OBJECTIVE: We investigate an association between high density of NK cells CD56+ and NK cells CD16+ into blood and secretory endometrium in patients with up to now unexplained recurrent miscarriage. At the same time, we focused on diagnosis of antiphospholipid syndrome, congenital trombophilic factors, stress factor, and lenght of hormonal contraception before conception...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/29018493/variation-in-the-hearing-threshold-in-women-during-the-menstrual-cycle
#13
Dayse da Silva Souza, Brunna Luckwu, Wagner Teobaldo Lopes de Andrade, Luciane Spinelli de Figueiredo Pessoa, João Agnaldo do Nascimento, Marine Raquel Diniz da Rosa
Introduction  The hormonal changes that occur during the menstrual cycle and their relationship with hearing problems have been studied. However, they have not been well explained. Objective  The objective of our study is to investigate the variation in hearing thresholds in women during the menstrual cycle. Method  We conducted a cohort and longitudinal study. It was composed of 30 volunteers, aged 18-39 years old, of which 20 were women during the phases of the menstrual cycle and 10 were men (control group) who underwent audiometry and impedance exams, to correlate the possible audiological changes in each phase of the menstrual cycle...
October 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29017868/rates-of-anovulation-in-adolescents-and-young-adults-with-moderate-to-severe-primary-dysmenorrhea-and-those-without-primary-dysmenorrhea
#14
Laura C Seidman, Kathleen M Brennan, Andrea J Rapkin, Laura A Payne
OBJECTIVE: To evaluate rates of presumptive anovulation in eumenorrheic adolescents and young adults with moderate to severe primary dysmenorrhea and those without primary dysmenorrhea. PARTICIPANTS: Thirty-nine adolescents and young adults (ages 16-24) with primary dysmenorrhea and 52 age-matched controls. DESIGN: Participants completed luteinizing hormone surge ovulation predictor test kits. Anovulatory cycles were defined by never receiving a positive result prior to the next menstrual period; participants were grouped as anovulatory if they experienced at least one anovulatory cycle during study participation...
October 7, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29017687/expression-of-vascular-endothelial-growth-factor-a-isoforms-is-dysregulated-in-women-with-endometriosis
#15
Kevin Danastas, Emily J Miller, Alison J Hey-Cunningham, Christopher R Murphy, Laura A Lindsay
Angiogenesis is a critical step in the development of ectopic lesions during endometriosis. Although total vascular endothelial growth factor (VEGF) A is elevated in the peritoneal fluid of women with endometriosis, there are contradictory reports on how levels of total endometrial VEGFA are altered in this disease. Furthermore, limited research is available on different VEGFA isoforms in women with endometriosis. Thus, the aim of the present study was to analyse levels of various VEGFA isoforms in women with and without endometriosis at different stages of the menstrual cycle...
October 11, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29017437/high-expression-of-high-mobility-group-box-1-in-menstrual-blood-implications-for-endometriosis
#16
Keiko Shimizu, Yasuhiko Kamada, Ai Sakamoto, Miwa Matsuda, Mikiya Nakatsuka, Yuji Hiramatsu
Endometriosis is a benign gynecologic disease characterized by the presence of ectopic endometrium and associated with inflammation and immune abnormalities. However, the molecular basis for endometriosis is not well understood. To address this issue, the present study examined the expression of high-mobility group box (HMGB) 1 in menstrual blood to investigate its role in the ectopic growth of human endometriotic stromal cells (ESCs). A total of 139 patients were enrolled in this study; 84 had endometriosis and 55 were nonendometriotic gynecological patients (control)...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29016234/limited-evidence-suggests-a-protective-association-between-oral-contraceptive-pill-use-and-anterior-cruciate-ligament-injuries-in-females-a-systematic-review
#17
Kathleen Samuelson, Ethan M Balk, Erika L Sevetson, Braden C Fleming
CONTEXT: Female athletes aged 14 to 18 years are at particular risk for anterior cruciate ligament (ACL) injuries. Hormonal factors are thought to predispose them to this injury. Oral contraceptive pills (OCPs) might reduce ACL injury risk, although the literature appears controversial. OBJECTIVE: To evaluate the association between OCP use and ACL injuries in women. The secondary objective was to determine the rates of ACL injuries in the pre- and postovulatory phases of the menstrual cycle in OCP and non-OCP (NOCP) users...
October 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28994639/migraine-menopause-and-hormone-replacement-therapy
#18
E Anne MacGregor
Perimenopause marks a period of increased migraine prevalence in women and many women also report troublesome vasomotor symptoms. Migraine is affected by fluctuating estrogen levels with evidence to support estrogen 'withdrawal' as a trigger of menstrual attacks of migraine without aura, while high estrogen levels can trigger migraine aura. Maintaining a stable estrogen environment with estrogen replacement can benefit estrogen-withdrawal migraine particularly in women who would also benefit from relief of vasomotor symptoms...
January 1, 2017: Post Reproductive Health
https://www.readbyqxmd.com/read/28993539/lung-function-response-and-side-effects-to-rapamycin-for-lymphangioleiomyomatosis-a-prospective-national-cohort-study
#19
Janet Bee, Sharon Fuller, Suzanne Miller, Simon R Johnson
RATIONALE: Mechanistic target of rapamycin inhibitors reduce loss of lung function in lymphangioleiomyomatosis (LAM), although their benefit varies between individuals. We examined lung function response and side effects to rapamycin in a national cohort. METHODS: Subjects were receiving rapamycin for progressive lung disease. Clinical evaluation, detailed phenotyping, serial lung function, rapamycin and safety monitoring were performed according to a clinical protocol...
October 9, 2017: Thorax
https://www.readbyqxmd.com/read/28991943/are-oral-emergency-contraceptives-a-safe-and-effective-form-of-long-term-birth-control
#20
Connie Kraus, Christopher Hooper-Lane
Yes, but not as effective as some other methods. Annual pregnancy rates in women using pericoital levonorgestrel 150 mcg to 1 mg range from 4.9% to 8.9%; menstrual irregularity is the most common adverse effect (strength of recommendation [SOR]: B, Cochrane review of lower-quality trials). In women younger than 35 years who have sexual intercourse 6 or fewer times per month, correct and consistent use of pericoital levonorgestrel 1.5 mg results in an annual pregnancy rate of 11% (SOR: B, one large prospective, open-label trial)...
October 2017: Journal of Family Practice
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