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https://www.readbyqxmd.com/read/28320223/kinect-3-a-phase-3-randomized-double-blind-placebo-controlled-trial-of-valbenazine-for-tardive-dyskinesia
#1
Robert A Hauser, Stewart A Factor, Stephen R Marder, Mary Ann Knesevich, Paul M Ramirez, Roland Jimenez, Joshua Burke, Grace S Liang, Christopher F O'Brien
OBJECTIVE: Tardive dyskinesia is a persistent movement disorder induced by dopamine receptor blockers, including antipsychotics. Valbenazine (NBI-98854) is a novel, highly selective vesicular monoamine transporter 2 inhibitor that demonstrated favorable efficacy and tolerability in the treatment of tardive dyskinesia in phase 2 studies. This phase 3 study further evaluated the efficacy, safety, and tolerability of valbenazine as a treatment for tardive dyskinesia. METHOD: This 6-week, randomized, double-blind, placebo-controlled trial included patients with schizophrenia, schizoaffective disorder, or a mood disorder who had moderate or severe tardive dyskinesia...
March 21, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28293023/advances-in-image-enhancement-in-colonoscopy-for-detection-of-adenomas
#2
REVIEW
Takahisa Matsuda, Akiko Ono, Masau Sekiguchi, Takahiro Fujii, Yutaka Saito
High-quality colonoscopy is mandatory to prevent adenoma recurrence and colorectal cancer. In the past few years, technical advances have been developed with the purpose of improving adenoma detection rate (ADR), one of the most important validated colonoscopy quality benchmarks. Several techniques or devices are used to optimize visualization: observation techniques; add-on devices; auxiliary imaging devices; colonoscopes with increased field of view; and colonoscopes with an integrated inflatable reusable balloon...
March 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28283788/follow-up-of-oral-and-oropharyngeal-cancer-using-narrow-band-imaging-and-high-definition-television-with-rigid-endoscope-to-obtain-an-early-diagnosis-of-second-primary-tumors-a-prospective-study
#3
Giancarlo Tirelli, Marco Piovesana, Pierluigi Bonini, Annalisa Gatto, Giuseppe Azzarello, Francesca Boscolo Nata
Narrow-band imaging (NBI) is an optical technique enhancing mucosal vasculature. The aim of this study is to assess the effectiveness of rigid NBI endoscopy in the early detection of second primaries or local recurrences after treatment for oral (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC), its advantage over standard white-light (WL) endoscopy, and the influence of previous radiotherapy, the learning curve, and lesion site. Between January 2013 and June 2015, 195 patients treated for OSCC or OPSCC with surgery alone (group A) or radiotherapy with or without surgery and/or chemotherapy (group B) underwent additional follow-up assessments using NBI...
March 10, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28276538/valbenazine-for-the-treatment-of-tardive-dyskinesia
#4
N Barquero
Valbenazine (NBI-98854, Ingrezza) is a highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor that modulates dopamine release during nerve communication. The pharmacological target VMAT2 may play an important role in the treatment of tardive dyskinesia (TD), an iatrogenic condition associated with the administration of antipsychotic medication for long periods and characterized by rapid, repetitive, stereotypic, involuntary movements of the face and extremities. There are currently no Food and Drug Administration (FDA)-approved drugs for the treatment of TD...
December 2016: Drugs of Today
https://www.readbyqxmd.com/read/28275908/narrow-band-imaging-enhances-the-detection-rate-of-penetration-and-aspiration-in-fees
#5
Julie C Nienstedt, Frank Müller, Almut Nießen, Susanne Fleischer, Jana-Christiane Koseki, Till Flügel, Christina Pflug
Narrow band imaging (NBI) is widely used in gastrointestinal, laryngeal, and urological endoscopy. Its original purpose was to visualize vessels and epithelial irregularities. Based on our observation that adding NBI to common white light (WL) improves the contrast of the test bolus in fiberoptic endoscopic evaluation of swallowing (FEES), we now investigated the potential value of NBI in swallowing disorders. 148 FEES images were analyzed from 74 consecutive patients with swallowing disorders, including 74 with and 74 without NBI...
March 9, 2017: Dysphagia
https://www.readbyqxmd.com/read/28266904/clinical-relevance-of-narrow-band-imaging-in-flexible-cystoscopy-the-dablaca-7-study
#6
Ditte Drejer, Sami Béji, Anna Munk Nielsen, Søren Høyer, Gitte Wrist Lam, Jørgen B Jensen
OBJECTIVE: This multicenter study investigated whether the use of narrow-band imaging (NBI) in flexible cystoscopy could improve diagnostics to a degree where clinical management was relevantly changed. MATERIALS AND METHODS: From May 2014 to June 2015, 955 patients were enrolled at three Danish urological departments. Patients had either hematuria (n = 483) or known recurrent non-muscle-invasive bladder cancer (NMIBC) (n = 472). High-definition (HD) cystoscopy was performed in white light (WL) and a preliminary clinical decision was made...
March 7, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28257790/the-diagnostic-performance-of-jnet-classification-for-differentiation-among-noninvasive-superficially-invasive-and-deeply-invasive-colorectal-neoplasia
#7
Kyoku Sumimoto, Shinji Tanaka, Kenjiro Shigita, Nana Hayashi, Daiki Hirano, Yuzuru Tamaru, Yuki Ninomiya, Shiro Oka, Koji Arihiro, Fumio Shimamoto, Masaharu Yoshihara, Kazuaki Chayama
BACKGROUNDS AND AIMS: The Japan NBI Expert Team (JNET) classification is the first universal narrow-band imaging (NBI) magnifying endoscopic classification of colorectal tumors. Considering each type in this classification, the diagnostic ability of Type 2B is the weakest. Generally, clinical behavior is thought to be different in each gross type of colorectal tumor. We evaluated the differences in the diagnostic performance of JNET classification for each gross type (polypoid and superficial) and examined whether the diagnostic performance of Type 2B could improve by subtyping...
February 28, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28248842/role-of-targeted-biopsy-under-magnifying-endoscopy-with-narrow-band-imaging-may-be-not-necessary-a-prospective-diagnostic-accuracy-study
#8
Qing-Wei Zhang, Ying Zhou, Jing-Jing Zhang, Hai-Yan Li, Jie-Ying Song, Zhi-Zheng Ge, Xiao-Bo Li
BACKGROUND AND AIMS: Targeted biopsy under the guidance of magnifying endoscopy with narrow band imaging (ME-NBI) has higher accuracy than endoscopic forceps biopsy (EFB) in the differential diagnosis of cancerous lesions from noncancerous lesions. The aims of this study were to validate diagnostic efficacy of targeted biopsy under the guidance of ME-NBI (MNTB) and further evaluate whether it is necessary to perform MNTB when combined with ME-NBI. METHODS: This study prospectively analyzed 211 gastric lesions of suspected cancerous tissues...
April 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28246479/clinical-impact-of-surveillance-for-head-and-neck-cancer-in-patients-with-esophageal-squamous-cell-carcinoma
#9
Hiroyuki Morimoto, Tomonori Yano, Yusuke Yoda, Yasuhiro Oono, Hiroaki Ikematsu, Ryuichi Hayashi, Atsushi Ohtsu, Kazuhiro Kaneko
AIM: To evaluate the clinical impact of surveillance for head and neck (HN) region with narrow band imaging (NBI) in patients with esophageal squamous cell carcinoma (ESCC). METHODS: Since 2006, we introduced the surveillance for HN region using NBI for all patients with ESCC before treatment, and each follow-up. The patients with newly diagnosed stage I to III ESCC were enrolled and classified into two groups as follows: Group A (no surveillance for HN region); between 1992 and 2000), and Group B (surveillance for HN region with NBI; between 2006 and 2008)...
February 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28244237/usefulness-of-confocal-laser-endomicroscopy-to-diagnose-ulcerative-colitis-associated-neoplasia
#10
Naoki Ohmiya, Noriyuki Horiguchi, Tomomitsu Tahara, Dai Yoshida, Hyuga Yamada, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Tetsuya Tsukamoto, Makoto Kuroda
Chromoendoscopy, narrow-band imaging (NBI), and confocal laser endomicroscopy (CLE) have been introduced in ulcerative colitis (UC)-associated neoplasia surveillance. We aimed to determine the ability of CLE to differentiate among UC-associated neoplasia (differentiated type or undifferentiated type), sporadic adenoma, and circumscribed regenerative lesions. Of 665 patients with UC, we performed probe-based CLE (pCLE) on 12 patients with suspected UC-associated neoplasia in addition to magnifying chromoendoscopy with crystal violet and NBI...
February 28, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28241961/simulation-of-laser-backscattering-system-for-imaging-of-inhomogeneity-tumor-in-biological-tissues
#11
J B Jeeva, Megha Singh
BACKGROUND AND OBJECTIVES: The optical characteristics of biological tissues vary in health and diseases. By analysis of photons scattering process by Monte Carlo simulation (MCS) the inhomogeneities in tissues are to be identified and their images reconstructed. METHODS: Digital phantoms with goat's heart as a control tissue embedded with inhomogeneities adipose (high scattering) and spleen (high absorption) are simulated. The phantoms considered are - (a) simulation of the developed stage of inhomogeneity by inclusion of adipose and spleen tissues in control and (b) its onset stage by increasing the optical parameters by 10% at fixed locations in control tissue...
April 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28236724/clinical-and-sociodemographic-variables-associated-with-interictal-dysphoric-disorder-and-interictal-personality-in-patients-with-drug-resistant-temporal-lobe-epilepsy-a-controlled-study
#12
Gerardo Maria de Araújo Filho, Bruna Tarifa, Raquel Espagnolla Santos, Ana Laura de Oliveira Dias, Júlia Rodrigues Leandro Ulliano, Lucia Helena Neves Marques
Psychiatric disorders (PD) have an elevated prevalence and an important negative impact on patients with epilepsy (PWE) since they are associated with lower quality of life and clinical refractoriness. However, it is also necessary to identify behavioral conditions possibly associated with epilepsy that are not part of the standard psychiatric classifications, such as Interictal Dysphoric Disorder (IDD) and Interictal Personality (IP). The frequency of IDD and IP in patients with drug-resistant temporal lobe epilepsy and mesial temporal sclerosis (TLE-MTS) was assessed...
February 22, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28231400/evaluation-of-the-combined-use-of-narrow-band-imaging-and-high-speed-imaging-to-discriminate-laryngeal-lesions
#13
Veronika Volgger, Axelle Felicio, Jörg Lohscheller, Anna S Englhard, Hanan Al-Muzaini, Christian S Betz, Maria E Schuster
BACKGROUND AND OBJECTIVE: Laryngeal lesions are usually investigated by microlaryngoscopy, biopsy, and histopathology. This study aimed to evaluate the combined use of Narrow Band Imaging (NBI) and High-Speed Imaging (HSI) in the differentiation of glottic lesions in awake patients. STUDY DESIGN: Prospective diagnostic study. MATERIALS AND METHODS: Thirty-six awake patients with 41 glottic lesions were investigated with both NBI and HSI, and the suspected diagnoses were compared to the histopathological results of tissue biopsies taken during subsequent microlaryngoscopies...
February 23, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28224618/the-feasibility-of-nbi-in-patients-with-suspected-upper-airway-lesions-a-multicenter-study
#14
Leif J J Bäck, Jami Rekola, Lassi Raittinen, Elina Halme, Petra Pietarinen, Harri Keski-Säntti, Leena-Maija Aaltonen, Antti A Mäkitie, Antti Raappana, Jukka Tikanto, Aleksi Schrey, Reidar Grenman, Jussi Laranne, Petri Koivunen, Heikki Irjala
OBJECTIVE: Narrow band imaging (NBI) improves diagnosis of laryngopharyngeal cancer, but most reported NBI studies are from experienced centers. Feasibility reports on use at everyday outpatient departments are needed. STUDY DESIGN: Researcher-initiated, prospective, multicenter. METHODS: Participating physicians were instructed in NBI technique during a 4-hour meeting. Patients underwent an examination that included endoscopy with white light (WL) high-definition (HD) TV and NBI filter in the selected time period...
February 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28216508/-idiopathic-mesenteric-phlebosclerosis-one-case-report-and-literature-review
#15
Yonghong Jiang, Shan Huang, Kequan Chen, Xueqing Chen
Idiopathic mesenteric phlebosclerosis (IMP) is a rare disease and it is easy to be misdiagnosed, which is characterized by intestinal obstruction symptoms, such as abdominal pain, bloating and vomiting. In this study, a case of IMP was observed and the literatures were reviewed. Computed tomography shows funicular high-density shadow and vascular calcification shadow along the vessels around the bowels. Narrow band imaging (M-NBI) endoscopy revealed the disappeared honeycomb capillary, the disordered microvascular structure and the increased density of blood vessels...
January 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28201841/evaluation-of-narrow-band-imaging-signs-in-eosinophilic-and-lymphocytic-esophagitis
#16
Tamaki Ichiya, Kyosuke Tanaka, Carlos A Rubio, Ulf Hammar, Peter T Schmidt
Background and study aims No specific endoscopic signs for diagnosing eosinophilic esophagitis (EoE) have been described and very few studies have reported endoscopic signs for lymphocytic esophagitis (LyE). This study aimed to assess the utility of narrow-band imaging magnifying endoscopy (NBI-ME) in predicting EoE/LyE diagnosis before histopathological assessment. Patients and methods Adult patients with dysphagia and/or food impaction who underwent esophagogastroduodenoscopy followed by NBI-ME and biopsies were included...
February 15, 2017: Endoscopy
https://www.readbyqxmd.com/read/28192481/a-meta-analysis-of-narrow-band-imaging-for-the-diagnosis-and-therapeutic-outcome-of-non-muscle-invasive-bladder-cancer
#17
YiQuan Xiong, JianDong Li, ShuJuan Ma, Jing Ge, LiZhi Zhou, Dongliang Li, Qing Chen
OBJECTIVES: To assess the additional detection rate (ADR) of within-patient comparisons of Narrow band imaging (NBI) and white light cystoscopy (WLC) for non-muscle invasive bladder cancer (NMIBC) detection and compare the impact of NBI and WLC on bladder cancer recurrence risk. METHODS: We searched relevant studies from PubMed, Embase, Medline, Web of Science and the Cochrane Library database for all articles in English published beforeJuly26th, 2016. Pooled ADR, diagnostic accuracy, relative risk (RR) and their 95% confidence intervals (CIs) were calculated...
2017: PloS One
https://www.readbyqxmd.com/read/28181962/use-of-narrow-band-imaging-in-the-diagnosis-of-hypovascular-endobronchial-sarcoidosis
#18
Rimoun Hakim, Bruce Sabath, Tugba Kaplan, Rex Yung
Narrow band imaging (NBI) has been widely applied for the evaluation of numerous disease conditions that present with increased vascularity of the mucosa, most often malignancies. It is increasingly being used in benign conditions as well. We present the first case in which NBI was used, rather, to detect areas of bronchial hypovascularity due to its ability to increase the visual contrast between normal and hypovascular mucosa. Endobronchial biopsy of these nodules led to the diagnosis of sarcoidosis. Had conventional white light alone been utilized, the diagnosis would likely have been missed because not only were these lesions difficult to visualize under white light but transbronchial lung biopsy and transbronchial needle aspiration were unremarkable...
February 8, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28168890/diagnostic-performance-of-narrow-band-imaging-for-laryngeal-cancer
#19
Changling Sun, Xue Han, Xiaoying Li, Yayun Zhang, Xiaodong Du
Objective To evaluate the performance of narrow band imaging (NBI) for the diagnosis of laryngeal cancer and to compare the diagnostic value of NBI with that of white light endoscopy. Data Sources PubMed, Embase, Cochrane Library, and CNKI databases. Review Methods Data analyses were performed with Meta-DiSc. The updated Quality Assessment of Diagnostic Accuracy Studies-2 tool was used to assess study quality and potential bias. Publication bias was assessed with the Deeks's asymmetry test. The protocol used in this article has been published on PROSPERO and is in accordance with the PRISMA checklist...
February 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28135297/acetic-acid-enhanced-narrow-band-imaging-for-the-diagnosis-of-gastric-intestinal-metaplasia
#20
Jie Sha, Pin Wang, Bingliang Zhu, Minghui Zhu, Xueliang Li, Feng Gao
Gastric intestinal metaplasia (GIM) is a precancerous lesion of the stomach. The detection of GIM using conventional white-light endoscopy (WLE) is difficult. In this study, we determined whether acetic acid-enhanced narrow band imaging (AA-NBI) improves the detection of GIM. A consecutive cohort of 132 individuals aged 40 years or older was subjected to upper gastrointestinal endoscopy using WLE, NBI and AA-NBI. The ability of the three methods to diagnose GIM in patients was compared. Histological assessment (per-patient and per-biopsy) was used for the accuracy assessment...
2017: PloS One
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