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Anurag Passi, Neeraj Kumar Rajput, David J Wild, Anshu Bhardwaj
Tuberculosis (TB) is the world's leading infectious killer with 1.8 million deaths in 2015 as reported by WHO. It is therefore imperative that alternate routes of identification of novel anti-TB compounds are explored given the time and costs involved in new drug discovery process. Towards this, we have developed RepTB. This is a unique drug repurposing approach for TB that uses molecular function correlations among known drug-target pairs to predict novel drug-target interactions. In this study, we have created a Gene Ontology based network containing 26,404 edges, 6630 drug and 4083 target nodes...
May 21, 2018: Journal of Cheminformatics
Tony Ma, Lenore Ellett, Kate McIlwaine, Janine Manwaring, Alex Eskander, Prathima Chowdary, Emma Readman, Peter Maher
STUDY OBJECTIVE: To assess the utility of narrow band imaging (NBI) to detect additional areas of endometriosis not identified by standard white light in patients undergoing laparoscopy for investigation of pelvic pain. DESIGN: Prospective cohort trial DESIGN CLASSIFICATION: Level II: Evidence obtained from well-designed cohort study. SETTING: Tertiary laparoscopic sub-specialty unit in Melbourne, Australia. PATIENTS: Fifty-seven patients undergoing laparoscopy for investigation of pelvic pain were recruited...
May 15, 2018: Journal of Minimally Invasive Gynecology
Georg Wimmer, Michael Gadermayr, Roland Kwitt, Michael Häfner, Toru Tamaki, Shigeto Yoshida, Shinji Tanaka, Dorit Merhof, Andreas Uhl
BACKGROUND: In medical image data sets, the number of images is usually quite small. The small number of training samples does not allow to properly train classifiers which leads to massive overfitting to the training data. In this work, we investigate whether increasing the number of training samples by merging datasets from different imaging modalities can be effectively applied to improve predictive performance. Further, we investigate if the extracted features from the employed image representations differ between different imaging modalities and if domain adaption helps to overcome these differences...
May 4, 2018: Computers in Biology and Medicine
J H Wu, X Y Luo
Objective: To explore the role of narrow band imaging (NBI) endoscopy in the diagnosis of oropharyngeal and laryngopharyngeal lesions. Method: NBI and white light (WLI) endoscopy were performed on 90 patients with oropharyngeal and laryngopharyngeal lesions from August 2016 to May 2017. NBI findings were classified into 5 types according to the Ni classification and were compared with histopathological results. Accuracy of NBI on premalignant and malignant lesions were compared with WLI. The connection between NBI findings and phathological results were explored...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Anna Rzepakowska, Ewelina Sielska-Badurek, Michal Żurek, Ewa Osuch-Wójcikiewicz, Kazimierz Niemczyk
BACKGROUND: This study investigates relevance of narrow band imaging (NBI) in stratifying risk of malignant transformation within leukoplakia. METHODS: We conducted a prospective analysis that included 62 patients with 91 changes of leukoplakia on vocal folds. The NBI was obtained before microsurgery. Categorization of the lesion as benign was made when vessels of surrounding epithelium were classified as type I, II, or IV according to Ni classification. If there were visualized intraepithelial papillary capillary loops of type V, the lesion was classified as malignant...
May 13, 2018: Head & Neck
Hongbo Zhao, Yinan Hu, Hua Sun, Wenquan Feng
The continuous wave interferences (CWIs) and the narrow-band interferences (NBIs) have significantly impacted the acquisition, tracking and positioning accuracy of Beidou Navigation Satellite System (BDS) receivers. As an interference suppression technology with a simple structure and low hardware cost, the adaptive infinite-duration impulse response (IIR) notch filter has been widely employed in the receivers to mitigate the CWIs and the NBIs. However, the nonlinear phase characteristics introduced by the IIR notch filters into the navigation receivers, may cause the distortion of navigation signals...
May 11, 2018: Sensors
Keiichiro Nakajo, Yasuhiro Oono, Takeshi Kuwata
An 80-year-old woman found to have a gastric tumor by endoscopy was referred to our hospital for further examination and treatment. Helicobacter pylori eradication therapy was successfully performed 10 years ago. Conventional endoscopy revealed a 20-mm flat elevated lesion in the greater curvature of the middle gastric body. (Fig. 1a). Magnifying endoscopy with narrow band imaging (M-NBI) revealed an irregular microvascular architecture, including closed-loop vessels with repeated irregular anastomoses (Fig...
May 5, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Chang Chun Li, Peng Chen, Guo Zheng Lu, Chun Yan Ma, Xiao Xiao Ma, Shuang Ting Wang
Nitrogen balance index (NBI) is one of the important indicators for crop growth. The high and low status of nitrogen can be quickly monitored by measuring NBI, which can provide accurate information of agricultural production and management. The relationship between NBI and original spectrum and derivative spectrum of infrared and near infrared wavelength from flowering to maturity stage was analyzed based on high definition digital image and hyperspectral data on unmanned aerial vehicles. Then, the sensitive bands were selected and the vegetation indexes were calculated...
April 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
L Staníková, R Walderová, D Jančatová, M Formánek, K Zeleník, Pavel Komínek
OBJECTIVE: The aim of this study was to compare narrow band imaging (NBI) endoscopy and Storz Professional Image Enhancement System (SPIES) in observing epithelial and/or subepithelial microvascular irregularities and pathologies. METHODS: A total of 73 patients with laryngeal or hypopharyngeal lesions were investigated using high-definition NBI endoscopy preoperatively in local anesthesia and using SPIES system intraoperatively in general anesthesia from August 2016 to October 2017...
April 30, 2018: European Archives of Oto-rhino-laryngology
Seiko Sasanuma, Kazuo Ohtsuka, Shin-Ei Kudo, Noriyuki Ogata, Yasuharu Maeda, Masashi Misawa, Yuichi Mori, Toyoki Kudo, Tomokauzu Hisayuki, Kunihiko Wakamura, Takemasa Hayashi, Atsushi Katagiri, Hideyuki Miyachi, Toshiyuki Baba, Fumio Ishida
Background and study aims:  Mucosal healing is a current treatment target in ulcerative colitis (UC), while histological remission is another target. The aim of this study was to evaluate the efficiency of magnified narrow band imaging (NBI) findings of mucosal healing and their relationship with histological activity and prognosis. Patients and methods:  Patients with UC who underwent total colonoscopy between January 2010 and December 2012 with left-sided or total-colitis type UC and achieved clinical remission with an endoscopic Mayo score of 0 or 1 were included...
May 2018: Endoscopy International Open
Seiichiro Abe, Yutaka Saito, Yasuhiro Oono, Yusaku Tanaka, Taku Sakamoto, Masayoshi Yamada, Takeshi Nakajima, Takahisa Matsuda, Hiroaki Ikematsu, Tomonori Yano, Shigeki Sekine, Motohiro Kojima, Hidetsugu Yamagishi, Hiroyuki Kato
BACKGROUND: The aim of this pilot study is to investigate the diagnostic yield of probe-based confocal laser endomicroscopy (pCLE) in the evaluation of depth of invasion in colorectal lesions. METHODS: Patients with colorectal lesions eligible for either endoscopic treatment or surgery were enrolled in the study. Tumor's depth of invasion was classified as mucosal or slight submucosal (M-SM1) and deep submucosal invasion or deeper (SM2 or deeper). White light endoscopy (WLE), magnifying narrow band imaging (M-NBI), and magnifying chromoendoscopy (M-CE) were used to assess colorectal lesions, and pCLE was used to identify tumor's features related to SM2 or deeper...
April 26, 2018: International Journal of Colorectal Disease
Wenxiu Diao, Xu Huang, Lei Shen, Zhi Zeng
BACKGROUND: Blue laser imaging (BLI) is a new image-enhanced endoscopy technique that utilizes a laser light source developed for narrow-band light observation. AIMS: To evaluate the value of BLI combined with magnifying endoscopy (M-BLI) for the diagnosis of early esophageal cancers (EECs). METHODS: This single-center prospective study analyzed 149 patients with focal esophageal lesions detected with white light endoscopy (WLE) at Renmin Hospital of Wuhan University between April 2015 and June 2017...
March 30, 2018: Digestive and Liver Disease
Nicole D Harriott, John P Williams, Evan B Smith, Haig P Bozigian, Dimitri E Grigoriadis
The dopaminergic system plays a key role in the central nervous system, regulating executive function, arousal, reward, and motor control. Dysregulation of this critical monoaminergic system has been associated with diseases of the central nervous system including schizophrenia, Parkinson's disease, and disorders such as attention deficit hyperactivity disorders and addiction. Drugs that modify the dopaminergic system by modulating the activity of dopamine have been successful in demonstrating clinical efficacy by providing treatments for these diseases...
2018: Progress in Medicinal Chemistry
Hiroyuki Aihara, Nitin Kumar, Christopher C Thompson
BACKGROUND: An education system for narrow band imaging (NBI) interpretation requires sufficient exposure to key features. However, access to didactic lectures by experienced teachers is limited in the United States. AIM: To develop and assess the effectiveness of a colorectal lesion identification tutorial. METHODS: In the image analysis pretest, subjects including 9 experts and 8 trainees interpreted 50 white light (WL) and 50 NBI images of colorectal lesions...
April 19, 2018: Digestion
Takahiro Kotachi, Masanori Ito, Tomoyuki Boda, Mariko Kiso, Kazuhiko Masuda, Kosaku Hata, Toru Kawamura, Yoji Sanomura, Masaharu Yoshihara, Shinji Tanaka, Kazuaki Chayama
BACKGROUND AND AIM: Reddish depressed lesions (RDLs) frequently observed in patients following Helicobacter pylori eradication are indistinguishable from gastric cancer. We examined the clinical and histological feature of RDLs and its relevant endoscopic diagnosis including magnifying narrow-band imaging (M-NBI). METHODS: We enrolled 301 consecutive patients with H. pylori eradication who underwent endoscopy using white light imaging (WLI). We examined the prevalence and host factors contributing to the presence of RDLs...
April 19, 2018: Digestion
Tina Schubert, Steffen Rausch, Omar Fahmy, Georgios Gakis, Arnulf Stenzl
Background: For over 100 years white-light cystoscopy has remained the gold-standard technique for the detection of bladder cancer (BCa). Some limitations in the detection of flat lesions (CIS), the differentiation between inflammation and malignancy, the inaccurate determination of the tumor margin status as well as the tumor depth, have led to a variety of technological improvements. The aim of this review is to evaluate the impact of these improvements in the diagnosis of BCa and their effectiveness in clinical practice...
November 2017: Therapeutic Advances in Urology
Takahiro Utsumi, Mineo Iwatate, Hironori Sunakawa, Akira Teramoto, Daizen Hirata, Santa Hattori, Wataru Sano, Noriaki Hasuike, Kazuhito Ichikawa, Takahiro Fujimori, Yasushi Sano
BACKGROUND AND AIM: Magnifying chromoendoscopy has been one of the most reliable diagnostic methods for distinguishing neoplastic from non-neoplastic lesions. The aim of this prospective study was to clarify the clinical usefulness of magnifying chromoendoscopy for colorectal polyps initially diagnosed with low confidence (LC) by magnifying narrow-band imaging (NBI). METHODS: Consecutive adult patients who underwent total colonoscopic examination with magnifying NBI between July and December 2016 at Sano Hospital were prospectively recruited...
April 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Yasushi Sano, Daizen Hirata, Yutaka Saito
The NICE classification is widely used around the world as a universal NBI endoscopic classification that is available without magnifying endoscopy. On the other hand, as histopathological criteria of curative endoscopic resection for early colorectal cancers is getting clear in Japan, endoscopists are required to diagnose their invasion depth accurately with magnifying endoscopy and obtain deeper histopathological materials by endoscopic mucosal resection (EMR)/endoscopic submucosal dissection (ESD). Therefore, we need a new classification which provides accurate qualitative and quantitative diagnosis linking to the appropriate treatment strategy including polypectomy, EMR/ESD, and surgery...
April 14, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Changling Sun, Yayun Zhang, Xue Han, Xiaodong Du
Objective The purposes of this study were to verify the effectiveness of the narrow band imaging (NBI) system in diagnosing nasopharyngeal cancer (NPC) as compared with white light endoscopy. Data Sources PubMed, Cochrane Library, EMBASE, CNKI, and Wan Fang databases. Review Methods Data analyses were performed with Meta-Disc. The updated Quality Assessment of Diagnostic Accuracy Studies-2 tool was used to assess study quality and potential bias. Publication bias was assessed with a Deeks asymmetry test. The registry number of the protocol published on PROSPERO is CRD42015026244...
March 1, 2018: Otolaryngology—Head and Neck Surgery
Mineo Iwatate, Yasushi Sano, Shinji Tanaka, Shin-Ei Kudo, Shoichi Saito, Takahisa Matsuda, Yoshiki Wada, Takahiro Fujii, Hiroaki Ikematsu, Toshio Uraoka, Nozomu Kobayashi, Hisashi Nakamura, Kinichi Hotta, Takahiro Horimatsu, Naoto Sakamoto, Kuang-I Fu, Osamu Tsuruta, Hiroshi Kawano, Hiroshi Kashida, Yoji Takeuchi, Hirohisa Machida, Toshihiro Kusaka, Naohisa Yoshida, Ichiro Hirata, Takeshi Terai, Hiro-O Yamano, Takeshi Nakajima, Taku Sakamoto, Yuichiro Yamaguchi, Naoto Tamai, Naoko Nakano, Nana Hayashi, Shiro Oka, Hideki Ishikawa, Yoshitaka Murakami, Shigeaki Yoshida, Yutaka Saito
OBJECTIVE: The Japan NBI Expert Team (JNET) was organized to unify four previous magnifying NBI classifications (the Sano, Hiroshima, Showa, and Jikei classifications). The JNET working group created criteria (referred to as the NBI scale) for evaluation of vessel pattern (VP) and surface pattern (SP). We conducted a multicenter validation study of the NBI scale to develop the JNET classification of colorectal lesions. METHODS: Twenty-five expert JNET colonoscopists read 100 still NBI images with and without magnification on the web to evaluate the NBI findings and the necessity of the criteria for the final diagnosis...
March 30, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
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