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https://www.readbyqxmd.com/read/28625679/phenotype-databases-for-genetic-screens-in-human-cells
#1
Benedikt Rauscher, Erica Valentini, Ulrike Hardeland, Michael Boutros
Genetic screens are powerful tools to identify components that make up biological systems. Perturbations introduced by methods such as RNA interference (RNAi) or CRISPR/Cas9-mediated genome editing lead to biological phenotypes that can be examined to understand the molecular function of genes in the cell. Over the years, many of such experiments have been conducted providing a wealth of knowledge about genotype-to-phenotype relationships. These data are a rich source of information and it is in a common interest to make them available in a simplified and integrated format...
June 15, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28611665/toll-like-receptor-4-in-paraventricular-nucleus-mediates-visceral-hypersensitivity-induced-by-maternal-separation
#2
Hui-Li Tang, Gongliang Zhang, Ning-Ning Ji, Lei Du, Bin-Bin Chen, Rong Hua, Yong-Mei Zhang
Neonatal maternal separation (MS) is a major early life stress that increases the risk of emotional disorders, visceral pain perception and other brain dysfunction. Elevation of toll-like receptor 4 (TLR4) signaling in the paraventricular nucleus (PVN) precipitates early life colorectal distension (CRD)-induced visceral hypersensitivity and pain in adulthood. The present study aimed to investigate the role of TLR4 signaling in the pathogenesis of postnatal MS-induced visceral hypersensitivity and pain during adulthood...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28611445/insulin-like-growth-factor-i-and-its-binding-protein-3-are-regulators-of-lactation-and-maternal-responsiveness
#3
András H Lékó, Melinda Cservenák, Éva Rebeka Szabó, János Hanics, Alán Alpár, Árpád Dobolyi
Adaptation to motherhood includes maternal behaviour and lactation during the postpartum period. The major organizing centres of maternal behaviour and lactation are located in the hypothalamic medial preoptic area (MPOA) and the arcuate nucleus, respectively. Insulin-like growth factor I (IGF-I) is an effector of the growth hormone axis; however, its function in the brain is largely unexplored. We identified increased maternal IGF binding protein-3 (IGFBP-3) expression in preoptic rat microarray data and confirmed it by RT-PCR...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28606611/bioinfra-prot-a-comprehensive-proteomics-workflow-including-data-standardization-protein-inference-expression-analysis-and-data-publication
#4
Michael Turewicz, Michael Kohl, Maike Ahrens, Gerhard Mayer, Julian Uszkoreit, Wael Naboulsi, Thilo Bracht, Dominik A Megger, Barbara Sitek, Katrin Marcus, Martin Eisenacher
The analysis of high-throughput mass spectrometry-based proteomics data must address the specific challenges of this technology. To this end, the comprehensive proteomics workflow offered by the de.NBI service center BioInfra.Prot provides indispensable components for the computational and statistical analysis of this kind of data. These components include tools and methods for spectrum identification and protein inference, protein quantification, expression analysis as well as data standardization and data publication...
June 9, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28606610/data-management-and-data-enrichment-for-systems-biology-projects
#5
Ulrike Wittig, Maja Rey, Andreas Weidemann, Wolfgang Müller
Collecting, curating, interlinking, and sharing high quality data are central to de.NBI-SysBio, the systems biology data management service center within the de.NBI network (German Network for Bioinformatics Infrastructure). The work of the center is guided by the FAIR principles for scientific data management and stewardship. FAIR stands for the four foundational principles Findability, Accessibility, Interoperability, and Reusability which were established to enhance the ability of machines to automatically find, access, exchange and use data...
June 9, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28596787/clinical-usefulness-of-the-vs-classification-system-using-magnifying-endoscopy-with-blue-laser-imaging-for-early-gastric-cancer
#6
Yoshikazu Yoshifuku, Yoji Sanomura, Shiro Oka, Kazutaka Kuroki, Mio Kurihara, Takeshi Mizumoto, Yuji Urabe, Toru Hiyama, Shinji Tanaka, Kazuaki Chayama
BACKGROUND: Blue laser imaging (BLI) enables the acquisition of more information from tumors' surfaces compared with white light imaging. Few reports confirm the validity of magnifying endoscopy (ME) with BLI (ME-BLI) for early gastric cancer (EGC). We aimed to assess the detailed endoscopic findings from EGCs using ME-BLI. METHODS: We enrolled 386 consecutive patients with 417 EGCs that were diagnosed using ME-BLI and resected by endoscopic submucosal dissection...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28596594/magnifying-narrow-band-imaging-of-gastric-mucosal-morphology-predicts-the-h-pylori-related-epigenetic-field-defect
#7
Tomomitsu Tahara, Jumpei Yamazaki, Sayumi Tahara, Masaaki Okubo, Tomohiko Kawamura, Noriyuki Horiguchi, Takamitsu Ishizuka, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Makoto Kuroda, Naoki Ohmiya
DNA methylation is associated with "field defect" in the gastric mucosa. To characterize "field defect" morphologically, we examined DNA methylation of non-neoplastic gastric mucosa in relation to their morphology seen by narrow-band imaging (NBI) with magnifying endoscopy. Magnifying NBI of non-neoplastic gastric body was classified as follows: normal-small and round pits with uniform subepithelial capillary networks; type 1-a little enlarged round pits with indistinct subepithelial capillary networks; type 2-remarkably enlarged pits with irregular vessels; and type 3-clearly demarcated oval or tubulovillous pits with bulky coiled or wavy vessels...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28593091/a-comprehensive-instrument-for-evaluating-mild-traumatic-brain-injury-mtbi-concussion-in-independent-adults-a-pilot-study
#8
Amanda Borges, Scot Raab, Monica Lininger
BACKGROUND: One common component of concussion rehabilitation is a computerized cognitive test free of concomitant physical demands. Healthcare professionals may be able to provide more patient-centered care after a diagnosed concussion if specific areas of impairment are identified and treated, such as the physical aspect of neurocognitive function. Hypothesis/Purpose: To evaluate the test-retest reliability of a unique combination of neurocognitive assessment tools currently utilized in concussion assessments into one single, inclusive instrument that measures both neurocognitive function and physical capability...
June 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28591047/inverted-gastric-adenocarcinoma-of-fundic-gland-mucosa-type-colliding-with-well-differentiated-adenocarcinoma-a-case-report
#9
Keitaro Takahashi, Mikihiro Fujiya, Shin Ichihara, Kentaro Moriichi, Toshikatsu Okumura
RATIONALE: Gastric adenocarcinoma of fundic gland mucosa type (GA-FGM) is a rare tumor composed of atypical cells with differentiation toward the fundic gland as well as the foveolar epithelium. Including our case, only 9 cases of GA-FGMs were reported from 2010 to 2016. CONCERNS OF THE PATIENT: An 87-year-old man was referred to our institution for endoscopic resection of a gastric lesion. The tumor was classified as type 0-I + IIa according to the Paris classification...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28575816/a-naphthalene-benzimidazole-based-chemosensor-for-the-colorimetric-and-on-off-fluorescent-detection-of-fluoride-ion
#10
Dongmei Li, Zhimin Zhong, Gengxiu Zheng, Zhongzhen Tian
A novel naphthalene benzimidazole (NBI)-based chemosensor (D2) was developed for fluoride ion (F(-)) detection. The absorption spectrum of D2 changed dramatically from yellow to blue in the visible region accompanied with a 225nm red shift of its absorption maximum upon the addition of F(-) in DMSO. D2 also exhibited a fluorescence turn-off response towards the fluoride ion. The emission intensity of D2 decreased drastically along the increasing F(-) concentration and the detection limit for F(-) was as low as 3...
May 24, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28560723/impact-of-distress-related-to-attenuated-psychotic-symptoms-in-individuals-at-ultra-high-risk-of-psychosis-findings-from-the-longitudinal-youth-at-risk-study
#11
Gurpreet Rekhi, Attilio Rapisarda, Jimmy Lee
AIM: Recent studies have highlighted that attenuated psychotic symptoms (APS) are an important source of distress in ultra high risk (UHR) individuals and that this distress is related to transition to psychosis (TTP). This study examined distress associated with APS in UHR individuals and investigated its association with TTP. METHODS: The Comprehensive Assessment of At-Risk Mental State (CAARMS) was used to identify 173 UHR individuals, who were included as participants in the study...
May 31, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28558410/french-comment-on-article-extending-magnifying-nbi-diagnosis-of-intestinal-metaplasia-in-the-stomach-the-white-opaque-substance-marker
#12
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Endoscopy
https://www.readbyqxmd.com/read/28557342/morphologic-characterization-of-residual-dna-methylation-in-the-gastric-mucosa-after-helicobacter-pylori-eradication
#13
Sayumi Tahara, Tomomitsu Tahara, Tetsuya Tuskamoto, Noriyuki Horiguchi, Tomohiko Kawamura, Masaaki Okubo, Takamitsu Ishizuka, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Makoto Kuroda, Naoki Ohmiya
Residual DNA methylation in the gastric mucosa after Helicobacter pylori (H. pylori) eradication may have a role in gastric carcinogenesis. We examined the association between morphologic features and promoter methylation status of non-neoplastic gastric mucosa especially after H. pylori eradication. A total of 140 gastric specimens from 99 participants who had at least 6 months of post-eradication period were examined. The magnifying narrow-band imaging (NBI) endoscopic feature of gastric mucosa was divided into two types: restored-small, round pits, accompanied with honeycomb-like subepithelial capillary networks; atrophic-well-demarcated oval or tubulovillous pits with clearly visible coiled or wavy vessels...
May 30, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28554830/rna-bioinformatics-tools-services-and-databases-for-the-analysis-of-rna-based-regulation
#14
Rolf Backofen, Jan Engelhardt, Anika Erxleben, Jörg Fallmann, Björn Grüning, Uwe Ohler, Nikolaus Rajewsky, Peter F Stadler
The importance of RNA-based regulation is becoming more and more evident. Genome-wide sequencing efforts have shown that the majority of the DNA in eukaryotic genomes is transcribed. Advanced high-throughput techniques like CLIP for the genome-wide detection of RNA-protein interactions have shown that post-transcriptional regulation by RNA-binding proteins matches the complexity of transcriptional regulation. The need for a specialized and integrated analysis of RNA-based data has led to the foundation of the RNA Bioinformatics Center (RBC) within the German Network of Bioinformatics Infrastructure (de...
May 26, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28552126/hue-texture-embedded-region-based-model-for-magnifying-endoscopy-with-narrow-band-imaging-image-segmentation-based-on-visual-features
#15
Xiaoqi Liu, Chengliang Wang, Jianying Bai, Guobin Liao, Yanjun Zhao
BACKGROUND AND OBJECTIVE: Magnification endoscopy with narrow-band imaging (ME-NBI) has become a feasible tool for detecting diseases within the human gastrointestinal tract, and is more applied by physicians to search for pathological abnormalities with gastric cancer such as precancerous lesions, early gastric cancer and advanced cancer. In order to improve the reliability of diseases detection, there is a need for applying or proposing computer-assisted methodologies to efficiently analyze and process ME-NBI images...
July 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28526945/tri-scan-a-three-stage-color-enhancement-tool-for-endoscopic-images
#16
Mohammad S Imtiaz, Shahed K Mohammed, Farah Deeba, Khan A Wahid
Modern endoscopes play a significant role in diagnosing various gastrointestinal (GI) tract related diseases where the visual quality of endoscopic images helps improving the diagnosis. This article presents an image enhancement method for color endoscopic images that consists of three stages, and hence termed as "Tri-scan" enhancement: (1) tissue and surface enhancement: a modified linear unsharp masking is used to sharpen the surface and edges of tissue and vascular characteristics; (2) mucosa layer enhancement: an adaptive sigmoid function is employed on the R plane of the image to highlight micro-vessels of the superficial layers of the mucosa and submucosa; and (3) color tone enhancement: the pixels are uniformly distributed to create an enhanced color effect to highlight the subtle micro-vessels, mucosa and tissue characteristics...
June 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28516968/preliminary-experience-with-4k-ultra-high-definition-endoscope-analysis-of-pros-and-cons-in-skull-base-surgery
#17
M Rigante, G La Rocca, L Lauretti, G Q D'Alessandris, A Mangiola, C Anile, A Olivi, G Paludetti
During the last two decades endoscopic skull base surgery observed a continuous technical and technological development 3D endoscopy and ultra High Definition (HD) endoscopy have provided great advances in terms of visualisation and spatial resolution. Ultra-high definition (UHD) 4K systems, recently introduced in the clinical practice, will shape next steps forward especially in skull base surgery field. Patients were operated on through transnasal transsphenoidal endoscopic approaches performed using Olympus NBI 4K UHD endoscope with a 4 mm 0° Ultra Telescope, 300 W xenon lamp (CLV-S400) predisposed for narrow band imaging (NBI) technology connected through a camera head to a high-quality control unit (OTV-S400 - VISERA 4K UHD) (Olympus Corporation, Tokyo, Japan)...
June 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28504491/profile-of-spontaneous-demand-for-services-among-infants-younger-than-30-days-old-at-a-children-s-tertiary-care-hospital
#18
Soledad Arbio, Nicolás Brunner, Eugenio Pierro, Susana Rodríguez, Diana Fariña
INTRODUCTION: In recent years, admission of critical newborn infants (NBIs) to the neonatal intensive care unit of Hospital Garrahan (HG) has been limited due to the hospitalization of infants younger than 30 days old through spontaneous demand for services. This is probably a multifactorial situation, and one of its causes is a lack of regionalization, which results in an inadequate use of resources or a distorted use of resources intended for more complex care. OBJECTIVE: To establish the profile of NBIs who make a spontaneous demand for services at HG and to assess the level of care required based on their medical condition...
June 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28503988/the-usefulness-of-narrow-band-imaging-for-the-diagnosis-and-treatment-of-vocal-fold-leukoplakia
#19
Fang Huang, Jinchao Yu, Fan Zhang, Changding He, Shimin Li, Jun Shao
OBJECTIVE: This research was aimed to explore the efficacy of narrow-band imaging (NBI) on distinguishing the degree of dysplasia of vocal fold leukoplakia. METHODS: Patients were examined by flexible endoscopy, under white light endoscopy (WLE) and NBI. 78 lesions were divided into two groups according to the NBI classification. Group 1: non-dysplasia (ND), including squamous hyperplasia with hyperkeratosis or parakeratosis; Group 2: squamous hyperplasia with mild or moderate dysplasia (MD) or severe dysplasia (SD), or carcinoma in situ (CIS)...
May 14, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28500570/narrow-band-imaging-can-increase-the-visibility-of-fibrin-caps-after-bleeding-of-esophageal-varices-a-case-with-extensive-esophageal-candidiasis
#20
Yoshihiro Furuichi, Yoshitaka Kasai, Hirohito Takeuchi, Yuu Yoshimasu, Takashi Kawai, Katsutoshi Sugimoto, Yoshiyuki Kobayashi, Ikuo Nakamura, Takao Itoi
A 58-year-old man with hepatitis B cirrhosis noticed black stools and underwent an endoscopy at a community hospital. The presence of esophageal varices (EVs) was confirmed, but the bleeding point was not found. He was referred to our institution and underwent a second endoscopy. Extensive white patches of esophageal candidiasis were visible on endoscopy by white-light imaging (WLI), but it was difficult to find the fibrin cap of the EVs. This was easier under narrow-band imaging (NBI), however, as the color turned red from absorption by hemoglobin adhered to it...
May 12, 2017: Clinical Journal of Gastroenterology
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