Jack M Shireman, Quinn White, Zijian Ni, Chitrasen Mohanty, Yujia Cai, Lei Zhao, Namita Agrawal, Nikita Gonugunta, Xiaohu Wang, Liam Mccarthy, Varshitha Kasulabada, Akshita Pattnaik, Atique U Ahmed, James Miller, Charles Kulwin, Aaron Cohen-Gadol, Troy Payner, Chih-Ta Lin, Jesse J Savage, Brandon Lane, Kevin Shiue, Aaron Kamer, Mitesh Shah, Gopal Iyer, Gordon Watson, Christina Kendziorski, Mahua Dey
Stereotactic radiosurgery (SRS) has been shown to be efficacious for the treatment of limited brain metastasis (BM); however, the effects of SRS on human brain metastases have yet to be studied. We performed genomic analysis on resected brain metastases from patients whose resected lesion was previously treated with SRS. Our analyses demonstrated for the first time that patients possess a distinct genomic signature based on type of treatment failure including local failure, leptomeningeal spread, and radio-necrosis...
April 19, 2024: IScience