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Multielectrode array

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https://www.readbyqxmd.com/read/29629879/a-nanofabricated-optoelectronic-probe-for-manipulating-and-recording-neural-dynamics
#1
Bingzhao Li, Kwang Lee, Sotiris C Masmanidis, Mo Li
OBJECTIVE: The convergence of optogenetic and large-scale neural recording technologies opens enormous opportunities for studying brain function. However, compared to the widespread use of optogenetics or recordings as standalone methods, the joint use of these techniques in behaving animals is much less well developed. A simple but poorly scalable solution has been to implant conventional optical fibers together with extracellular microelectrodes. A more promising approach has been to combine microfabricated light emission sources with multielectrode arrays...
April 9, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29593975/ultraconformable-temporary-tattoo-electrodes-for-electrophysiology
#2
Laura M Ferrari, Sudha Sudha, Sergio Tarantino, Roberto Esposti, Francesco Bolzoni, Paolo Cavallari, Christian Cipriani, Virgilio Mattoli, Francesco Greco
Electrically interfacing the skin for monitoring personal health condition is the basis of skin-contact electrophysiology. In the clinical practice the use of stiff and bulky pregelled or dry electrodes, in contrast to the soft body tissues, imposes severe restrictions to user comfort and mobility while limiting clinical applications. Here, in this work dry, unperceivable temporary tattoo electrodes are presented. Customized single or multielectrode arrays are readily fabricated by inkjet printing of conducting polymer onto commercial decal transfer paper, which allows for easy transfer on the user's skin...
March 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29570062/sub-100-nw-volatile-nano-metal-oxide-memristor-as-synaptic-like-encoder-of-neuronal-spikes
#3
Isha Gupta, Alexantrou Serb, Ali Khiat, Ralf Zeitler, Stefano Vassanelli, Themistoklis Prodromakis
Advanced neural interfaces mediate a bioelectronic link between the nervous system and microelectronic devices, bearing great potential as innovative therapy for various diseases. Spikes from a large number of neurons are recorded leading to creation of big data that require online processing under most stringent conditions, such as minimal power dissipation and on-chip space occupancy. Here, we present a new concept where the inherent volatile properties of a nano-scale memristive device are used to detect and compress information on neural spikes as recorded by a multielectrode array...
April 2018: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/29564797/functional-assessment-of-melanopsin-driven-light-responses-in-the-mouse-multielectrode-array-recordings
#4
Shi-Jun Weng, Jordan M Renna, Wei-Yi Chen, Xiong-Li Yang
Intrinsically photosensitive retinal ganglion cells (ipRGCs) are a special subset of retinal output neurons capable of detecting and responding to light via a unique photopigment called melanopsin. Melanopsin activation is essential to a wide array of physiological functions, especially to those related to non-image-forming vision. Since ipRGCs only constitute a very small proportion of retinal ganglion cells, targeted recording of melanopsin-driven responses used to be a big challenge to vision researchers...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29557782/a-spike-sorting-toolbox-for-up-to-thousands-of-electrodes-validated-with-ground-truth-recordings-in-vitro-and-in-vivo
#5
Pierre Yger, Giulia Lb Spampinato, Elric Esposito, Baptiste Lefebvre, Stéphane Deny, Christophe Gardella, Marcel Stimberg, Florian Jetter, Guenther Zeck, Serge Picaud, Jens Duebel, Olivier Marre
In recent years, multielectrode arrays and large silicon probes have been developed to record simultaneously between hundreds and thousands of electrodes packed with a high density. However, they require novel methods to extract the spiking activity of large ensembles of neurons. Here we developed a new toolbox to sort spikes from these large-scale extracellular data. To validate our method, we performed simultaneous extracellular and loose patch recordings in rodents to obtain 'ground truth' data, where the solution to this sorting problem is known for one cell...
March 20, 2018: ELife
https://www.readbyqxmd.com/read/29474358/technical-feasibility-study-for-production-of-tailored-multielectrode-arrays-and-patterning-of-arranged-neuronal-networks
#6
Matthias Schürmann, Norman Shepheard, Natalie Frese, Kevin Geishendorf, Holger Sudhoff, Armin Gölzhäuser, Ulrich Rückert, Christian Kaltschmidt, Barbara Kaltschmidt, Andy Thomas
In this manuscript, we first reveal a simple ultra violet laser lithographic method to design and produce plain tailored multielectrode arrays. Secondly, we use the same lithographic setup for surface patterning to enable controlled attachment of primary neuronal cells and help neurite guidance. For multielectrode array production, we used flat borosilicate glass directly structured with the laser lithography system. The multi layered electrode system consists of a layer of titanium coated with a layer of di-titanium nitride...
2018: PloS One
https://www.readbyqxmd.com/read/29428663/shengmai-san-derived-herbal-prevents-the-development-of-a-vulnerable-substrate-for-atrial-fibrillation-in-a-rat-model-of-ischemic-heart-failure
#7
Jin Ma, Shiyu Ma, Chunxia Yin, Huanlin Wu
OBJECTIVE: The study aimed to investigate whether a Shengmai San-derived herbal, Fumai granule (FM), which had a preventive effect on atrial fibrillation (AF) in myocardial infarction (MI)-induced heart failure (HF) rat and to determine the underlying mechanisms. DESIGN AND METHODS: MI was induced by a ligation of the left anterior descending coronary artery. One week after MI surgery, FM was gavaged for 4 weeks. AF inducibility was detected by transesophageal programmed electrical stimulation technology...
February 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29426889/sio2-nanoparticles-modulate-the-electrical-activity-of-neuroendocrine-cells-without-exerting-genomic-effects
#8
C Distasi, F A Ruffinatti, M Dionisi, S Antoniotti, A Gilardino, G Croci, B Riva, E Bassino, G Alberto, E Castroflorio, D Incarnato, E Morandi, G Martra, S Oliviero, L Munaron, D Lovisolo
Engineered silica nanoparticles (NPs) have attracted increasing interest in several applications, and particularly in the field of nanomedicine, thanks to the high biocompatibility of this material. For their optimal and controlled use, the understanding of the mechanisms elicited by their interaction with the biological target is a prerequisite, especially when dealing with cells particularly vulnerable to environmental stimuli like neurons. Here we have combined different electrophysiological approaches (both at the single cell and at the population level) with a genomic screening in order to analyze, in GT1-7 neuroendocrine cells, the impact of SiO2 NPs (50 ± 3 nm in diameter) on electrical activity and gene expression, providing a detailed analysis of the impact of a nanoparticle on neuronal excitability...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29377795/statistically-reconstructed-multiplexing-for-very-dense-high-channel-count-acquisition-systems
#9
David Tsai, Rafael Yuste, Kenneth L Shepard
Multiplexing is an important strategy in multichannel acquisition systems. The per-channel antialiasing filters needed in the traditional multiplexing architecture limit its scalability for applications requiring high channel density, high channel count, and low noise. A particularly challenging example is multielectrode arrays for recording from neural systems. We show that conventional approaches must tradeoff recording density and noise performance, at a scale far from the ideal goal of one-to-one mapping between neurons and sensors...
February 2018: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/29372259/lycium-barbarum-polysaccharides-protect-retina-in-rd1-mice-during-photoreceptor-degeneration
#10
Feng Liu, Jia Zhang, Zongqin Xiang, Di Xu, Kwok-Fai So, Noga Vardi, Ying Xu
Purpose: As an active component in wolfberry, lycium barbarum polysaccharides (LBP) are capable of protecting retinal neurons in several animal disease models. Here, we asked whether LBP rescues the retinal morphology and function in rd1 mouse, a photoreceptor fast-degenerating animal model of retinitis pigmentosa, and in particular focused on LBP's effects on the function of retinal ganglion cells (RGCs) during photoreceptor degeneration. Methods: An equal volume of LBP or control vehicle was daily intraperitoneal (i...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29351358/microfluidics-based-subretinal-chemical-neuromodulation-of-photoreceptor-degenerated-retinas
#11
Corey M Rountree, John B Troy, Laxman Saggere
Purpose: Retinal prostheses can restore rudimentary vision in cases of photoreceptor degeneration through electrical stimulation, but face difficulties achieving high spatial resolution because electrical current is an inherently unnatural stimulus. We investigated the therapeutic feasibility of using patterned delivery of the glutamate neurotransmitter, a primary agent of natural synaptic communication of the retina, as a biomimetic chemical alternative to electrical current for neuromodulation of photoreceptor degenerate retina...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29346110/a-three-dimensional-arrayed-microfluidic-blood-brain-barrier-model-with-integrated-electrical-sensor-array
#12
Sehoon Jeong, Sunja Kim, John Buonocore, Jaewon Park, C Jane Welsh, Jianrong Li, Arum Han
OBJECTIVE: The blood-brain barrier (BBB) poses a unique challenge to the development of therapeutics against neurological disorders due to its impermeabi-lity to most of the chemical compounds. Most in vitro BBB models have limitations in mimicking in vivo conditions and functions. Here, we show a co-culture microfluidic BBB-on-a-chip that provides interactions between neurovascular endothelial cells and neuronal cells across a porous polycarbonate membrane, which better mimics the in vivo conditions, as well as allows in vivo level shear stress to be applied...
February 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29342363/differential-effects-of-inhibitory-g-protein-isoforms-on-g-protein-gated-inwardly-rectifying-k-currents-in-adult-murine-atria
#13
Muriel Nobles, David Montaigne, Sonia Sebastian, Lutz Birnbaumer, Andrew Tinker
G-protein gated inwardly rectifying K+ (GIRK) channels are the major inwardly rectifying K+ currents in cardiac atrial myocytes and an important determinant of atrial electrophysiology. Inhibitory G-protein alpha subunits can both mediate activation via acetylcholine but can also supress basal currents in the absence of agonist. We studied this phenomenon using whole cell patch clamping in murine atria from mice with global genetic deletion of Gαi2, combined deletion of Gαi1/Gαi3 and littermate controls...
January 17, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29129319/modeling-the-interplay-between-neurons-and-astrocytes-in-autism-using-human-induced-pluripotent-stem-cells
#14
Fabiele Baldino Russo, Beatriz Camille Freitas, Graciela Conceição Pignatari, Isabella Rodrigues Fernandes, Jonathan Sebat, Alysson Renato Muotri, Patricia Cristina Baleeiro Beltrão-Braga
BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with unclear etiology and imprecise genetic causes. The main goal of this work was to investigate neuronal connectivity and the interplay between neurons and astrocytes from individuals with nonsyndromic ASD using induced pluripotent stem cells. METHODS: Induced pluripotent stem cells were derived from a clinically well-characterized cohort of three individuals with nonsyndromic ASD sharing common behaviors and three control subjects, two clones each...
October 3, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29093659/closed-loop-experiment-manager-clem-an-open-and-inexpensive-solution-for-multichannel-electrophysiological-recordings-and-closed-loop-experiments
#15
Hananel Hazan, Noam E Ziv
There is growing need for multichannel electrophysiological systems that record from and interact with neuronal systems in near real-time. Such systems are needed, for example, for closed loop, multichannel electrophysiological/optogenetic experimentation in vivo and in a variety of other neuronal preparations, or for developing and testing neuro-prosthetic devices, to name a few. Furthermore, there is a need for such systems to be inexpensive, reliable, user friendly, easy to set-up, open and expandable, and possess long life cycles in face of rapidly changing computing environments...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29060067/a-comparative-study-of-light-and-electrically-evoked-response-of-retinal-ganglion-cells
#16
Satarupa Biswas, Debdeep Sikdar, Soumen Das, Manjunatha Mahadevappa
Understanding of the evoked neural discharges from retinal tissues is vital for designing of any retinal prosthesis. In this study, retinal ganglion cell activity to light and electrical stimulus is recorded using multielectrode arrays. For an effective epiretinal prosthetic device, the electrical stimulus through the prosthesis should be able to evoke responses similar to those of light response in normal condition. This pilot study was intended to design the experimental protocol for in-vitro retinal stimulation...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29046428/spatio-temporal-characteristics-of-retinal-response-to-network-mediated-photovoltaic-stimulation
#17
Elton Ho, Richard Smith, Georges A Goetz, Xin Lei, Ludwig Galambos, Theodore I Kamins, James Harris, Keith Mathieson, Daniel Palanker, Alexander Sher
Subretinal prostheses aim at restoring sight to patients blinded by photoreceptor degeneration using electrical activation of the surviving inner retinal neurons. Today, such implants deliver visual information with low-frequency stimulation, resulting in discontinuous visual percepts. We measured retinal responses to complex visual stimuli delivered at video rate via a photovoltaic subretinal implant and by visible light. Using a multielectrode array to record from retinal ganglion cells (RGCs) in the healthy and degenerated rat retina ex-vivo, we estimated their spatio-temporal properties from the spike-triggered average (STA) responses to photovoltaic binary white noise stimulus with 70μm pixel size at 20Hz frame rate...
October 18, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29024244/local-chemical-stimulation-of-neurons-with-the-fluidfm
#18
Matthias J Aebersold, Harald Dermutz, László Demkó, José F Saenz Cogollo, Shiang-Chi Lin, Conrad Burchert, Moritz Schneider, Doris Ling, Csaba Forró, Hana Han, Tomaso Zambelli, Janos Vörös
Physiological communication between neurons is dependent on the exchange of neurotransmitters at the synapses. Although such chemical signal transmission targets specific receptors and allows for subtle adaptation of the action potential, in vitro neuroscience typically relies on electrical currents and potentials to stimulate neurons. The electric stimulus is unspecific and the confinement of the stimuli within the media is technically difficult to control and introduces large artifacts in electric recordings of the activity...
October 10, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28973319/differential-effects-of-hcn-channel-block-on-on-and-off-pathways-in-the-retina-as-a-potential-cause-for-medication-induced-phosphene-perception
#19
Sebastian Bemme, Michael Weick, Tim Gollisch
Purpose: Phosphene perception is a characteristic side effect of heart rate-reducing medication that acts on hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels. It is hypothesized that these phosphenes are caused by blocking HCN channels in photoreceptors and neurons of the retina, yet the underlying changes in visual signal processing in the retina caused by the HCN channel block are still unknown. Methods: We examined the effects of pharmacologic HCN channel block on the encoding of visual signals in retinal ganglion cells by recording ganglion cell spiking activity from isolated mouse retinas mounted on multielectrode arrays...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28930702/gcamp-expression-in-retinal-ganglion-cells-characterized-using-a-low-cost-fundus-imaging-system
#20
Yao-Chuan Chang, Steven T Walston, Robert H Chow, James D Weiland
OBJECTIVE: Virus-transduced, intracellular-calcium indicators are effective reporters of neural activity, offering the advantage of cell-specific labeling. Due to the existence of an optimal time window for the expression of calcium indicators, a suitable tool for tracking GECI expression in vivo following transduction is highly desirable. APPROACH: We developed a noninvasive imaging approach based on a custom-modified, low-cost fundus viewing system that allowed us to monitor and characterize in vivo bright-field and fluorescence images of the mouse retina...
October 2017: Journal of Neural Engineering
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