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Multielectrode array

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https://www.readbyqxmd.com/read/29890190/dysregulation-and-restoration-of-homeostatic-network-plasticity-in-fragile-x-syndrome-mice
#1
Kathryn A Jewett, Kwan Young Lee, Daphne E Eagleman, Stephanie Soriano, Nien-Pei Tsai
Chronic activity perturbations in neurons induce homeostatic plasticity through modulation of synaptic strength or other intrinsic properties to maintain the correct physiological range of excitability. Although similar plasticity can also occur at the population level, what molecular mechanisms are involved remain unclear. In the current study, we utilized a multielectrode array (MEA) recording system to evaluate homeostatic neural network activity of primary mouse cortical neuron cultures. We demonstrated that chronic elevation of neuronal activity through the inhibition of GABA(A) receptors elicits synchronization of neural network activity and homeostatic reduction of the amplitude of spontaneous neural network spikes...
June 8, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29803020/arterial-hypertension-drives-arrhythmia-progression-via-specific-structural-remodeling-in-a-porcine-model-of-atrial-fibrillation
#2
Martin Manninger, David Zweiker, Arne van Hunnik, Alessio Alogna, Anton J Prassl, Julia Schipke, Stef Zeemering, Birgit Zirngast, Patrick Schönleitner, Michael Schwarzl, Viktoria Herbst, Eva Thon-Gutschi, Stefan Huber, Ursula Rohrer, Jakob Ebner, Helmut Brussee, Burkert M Pieske, Frank R Heinzel, Sander Verheule, Gudrun Antoons, Andreas Lueger, Christian Mühlfeld, Gernot Plank, Ulrich Schotten, Heiner Post, Daniel Scherr
BACKGROUND: Arterial hypertension (HT) contributes to progression of atrial fibrillation (AF) via unknown mechanisms. OBJECTIVE: We aimed to characterize electrical and structural changes accounting for increased AF stability in a large animal model of rapid atrial pacing (RAP) induced AF combined with desoxycorticosterone acetate (DOCA) induced HT. METHODS: Eighteen pigs were instrumented with right atrial endocardial pacemaker leads and custom-made pacemakers to induce AF by continuous RAP (600bpm)...
May 23, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29787427/impact-of-ionizing-radiation-on-electrophysiological-behavior-of-human-induced-ipsc-derived-cardiomyocytes-on-multielectrode-arrays
#3
Benjamin V Becker, Thomas Seeger, Thomas Beiert, Markus Antwerpen, Andreas Palnek, Matthias Port, Reinhard Ullmann
Cardiac arrhythmia presumably induced through cardiac fibrosis is a recurrent long-term consequence of exposure to ionizing radiation. However, there is also evidence that cardiac arrhythmia can occur in patients shortly after irradiation. In this study, the authors employed multielectrode arrays to investigate the short-term effects of x-ray radiation on the electrophysiological behavior of cardiomyocytes derived from human-induced pluripotent stem cells. These cardiomyocytes with spontaneous pacemaker activity were cultured on single-well multielectrode arrays...
July 2018: Health Physics
https://www.readbyqxmd.com/read/29757347/role-of-inhibitory-control-in-modulating-focal-seizure-spread
#4
Jyun-You Liou, Hongtao Ma, Michael Wenzel, Mingrui Zhao, Eliza Baird-Daniel, Elliot H Smith, Andy Daniel, Ronald Emerson, Rafael Yuste, Theodore H Schwartz, Catherine A Schevon
Focal seizure propagation is classically thought to be spatially contiguous. However, distribution of seizures through a large-scale epileptic network has been theorized. Here, we used a multielectrode array, wide field calcium imaging, and two-photon calcium imaging to study focal seizure propagation pathways in an acute rodent neocortical 4-aminopyridine model. Although ictal neuronal bursts did not propagate beyond a 2-3-mm region, they were associated with hemisphere-wide field potential fluctuations and parvalbumin-positive interneuron activity outside the seizure focus...
May 10, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29752231/temporal-neuromodulation-of-retinal-ganglion-cells-by-low-frequency-focused-ultrasound-stimulation
#5
Qiuju Jiang, Guofeng Li, Huixia Zhao, Wenlong Sheng, Lan Yue, Min Su, Shijun Weng, Leanne Lai-Hang Chan, Qifa Zhou, Mark S Humayun, Weibao Qiu, Hairong Zheng
Significant progress has been made recently in treating neurological blindness using implantable visual prostheses. However, implantable medical devices are highly invasive and subject to many safety, efficacy, and cost issues. The discovery that ultrasound (US) may be useful as a noninvasive neuromodulation tool has aroused great interest in the field of acoustic retinal prostheses (ARPs). We have investigated the responsiveness of rat retinal ganglion cells (RGCs) to low-frequency focused US stimulation (LFUS) at 2...
May 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29738986/neural-data-science-accelerating-the-experiment-analysis-theory-cycle-in-large-scale-neuroscience
#6
REVIEW
L Paninski, J P Cunningham
Modern large-scale multineuronal recording methodologies, including multielectrode arrays, calcium imaging, and optogenetic techniques, produce single-neuron resolution data of a magnitude and precision that were the realm of science fiction twenty years ago. The major bottlenecks in systems and circuit neuroscience no longer lie in simply collecting data from large neural populations, but also in understanding this data: developing novel scientific questions, with corresponding analysis techniques and experimental designs to fully harness these new capabilities and meaningfully interrogate these questions...
April 19, 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29721420/a-micropatterned-multielectrode-shell-for-3d-spatiotemporal-recording-from-live-cells
#7
Jordi Cools, Qianru Jin, Eugene Yoon, Diego Alba Burbano, Zhenxiang Luo, Dieter Cuypers, Geert Callewaert, Dries Braeken, David H Gracias
Microelectrode arrays (MEAs) have proved to be useful tools for characterizing electrically active cells such as cardiomyocytes and neurons. While there exist a number of integrated electronic chips for recording from small populations or even single cells, they rely primarily on the interface between the cells and 2D flat electrodes. Here, an approach that utilizes residual stress-based self-folding to create individually addressable multielectrode interfaces that wrap around the cell in 3D and function as an electrical shell-like recording device is described...
April 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29692701/multisite-attenuated-intracellular-recordings-by-extracellular-multielectrode-arrays-a-perspective
#8
Micha E Spira, Nava Shmoel, Shun-Ho M Huang, Hadas Erez
Multielectrode arrays (MEA) are used extensively for basic and applied electrophysiological research of neuronal- and cardiomyocyte-networks. Whereas immense progress has been made in realizing sophisticated MEA platforms of thousands of addressable, high-density, small diameter, low impedance sensors, the quality of the interfaces formed between excitable cells and classical planar sensor has not improved. As a consequence in vitro and in vivo MEA are "blind" to the rich and important "landscape" of sub-threshold synaptic potentials generated by individual neurons...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29677150/mapping-the-galvanic-corrosion-of-three-coupled-metal-alloys-using-coupled-multielectrode-array-influence-of-chloride-ion-concentration
#9
Hong Ju, JinZhuo Duan, Yuanfeng Yang, Ning Cao, Yan Li
The galvanic corrosion behavior of three metal alloys commonly used in water desalination plants was investigated using coupled multielectrode arrays consisting of aluminum-brass (HAl77-2), titanium alloy (TA2), and 316L stainless steel (316L SS). The three electrode types were coupled galvanically and arranged in different geometric configurations. Their corrosion behavior was characterized as a function of the chloride concentration. The potential and current distributions of the three-electrode coupling systems display electrochemical inhomogeneity...
April 20, 2018: Materials
https://www.readbyqxmd.com/read/29629879/a-nanofabricated-optoelectronic-probe-for-manipulating-and-recording-neural-dynamics
#10
Bingzhao Li, Kwang Lee, Sotiris C Masmanidis, Mo Li
OBJECTIVE: The convergence of optogenetic and large-scale neural recording technologies opens enormous opportunities for studying brain function. However, compared to the widespread use of optogenetics or recordings as standalone methods, the joint use of these techniques in behaving animals is much less well developed. A simple but poorly scalable solution has been to implant conventional optical fibers together with extracellular microelectrodes. A more promising approach has been to combine microfabricated light emission sources with multielectrode arrays...
April 9, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29593975/ultraconformable-temporary-tattoo-electrodes-for-electrophysiology
#11
Laura M Ferrari, Sudha Sudha, Sergio Tarantino, Roberto Esposti, Francesco Bolzoni, Paolo Cavallari, Christian Cipriani, Virgilio Mattoli, Francesco Greco
Electrically interfacing the skin for monitoring personal health condition is the basis of skin-contact electrophysiology. In the clinical practice the use of stiff and bulky pregelled or dry electrodes, in contrast to the soft body tissues, imposes severe restrictions to user comfort and mobility while limiting clinical applications. Here, in this work dry, unperceivable temporary tattoo electrodes are presented. Customized single or multielectrode arrays are readily fabricated by inkjet printing of conducting polymer onto commercial decal transfer paper, which allows for easy transfer on the user's skin...
March 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29570062/sub-100-nw-volatile-nano-metal-oxide-memristor-as-synaptic-like-encoder-of-neuronal-spikes
#12
Isha Gupta, Alexantrou Serb, Ali Khiat, Ralf Zeitler, Stefano Vassanelli, Themistoklis Prodromakis
Advanced neural interfaces mediate a bioelectronic link between the nervous system and microelectronic devices, bearing great potential as innovative therapy for various diseases. Spikes from a large number of neurons are recorded leading to creation of big data that require online processing under most stringent conditions, such as minimal power dissipation and on-chip space occupancy. Here, we present a new concept where the inherent volatile properties of a nano-scale memristive device are used to detect and compress information on neural spikes as recorded by a multielectrode array...
April 2018: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/29564797/functional-assessment-of-melanopsin-driven-light-responses-in-the-mouse-multielectrode-array-recordings
#13
Shi-Jun Weng, Jordan M Renna, Wei-Yi Chen, Xiong-Li Yang
Intrinsically photosensitive retinal ganglion cells (ipRGCs) are a special subset of retinal output neurons capable of detecting and responding to light via a unique photopigment called melanopsin. Melanopsin activation is essential to a wide array of physiological functions, especially to those related to non-image-forming vision. Since ipRGCs only constitute a very small proportion of retinal ganglion cells, targeted recording of melanopsin-driven responses used to be a big challenge to vision researchers...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29557782/a-spike-sorting-toolbox-for-up-to-thousands-of-electrodes-validated-with-ground-truth-recordings-in-vitro-and-in-vivo
#14
Pierre Yger, Giulia Lb Spampinato, Elric Esposito, Baptiste Lefebvre, Stéphane Deny, Christophe Gardella, Marcel Stimberg, Florian Jetter, Guenther Zeck, Serge Picaud, Jens Duebel, Olivier Marre
In recent years, multielectrode arrays and large silicon probes have been developed to record simultaneously between hundreds and thousands of electrodes packed with a high density. However, they require novel methods to extract the spiking activity of large ensembles of neurons. Here, we developed a new toolbox to sort spikes from these large-scale extracellular data. To validate our method, we performed simultaneous extracellular and loose patch recordings in rodents to obtain 'ground truth' data, where the solution to this sorting problem is known for one cell...
March 20, 2018: ELife
https://www.readbyqxmd.com/read/29474358/technical-feasibility-study-for-production-of-tailored-multielectrode-arrays-and-patterning-of-arranged-neuronal-networks
#15
Matthias Schürmann, Norman Shepheard, Natalie Frese, Kevin Geishendorf, Holger Sudhoff, Armin Gölzhäuser, Ulrich Rückert, Christian Kaltschmidt, Barbara Kaltschmidt, Andy Thomas
In this manuscript, we first reveal a simple ultra violet laser lithographic method to design and produce plain tailored multielectrode arrays. Secondly, we use the same lithographic setup for surface patterning to enable controlled attachment of primary neuronal cells and help neurite guidance. For multielectrode array production, we used flat borosilicate glass directly structured with the laser lithography system. The multi layered electrode system consists of a layer of titanium coated with a layer of di-titanium nitride...
2018: PloS One
https://www.readbyqxmd.com/read/29428663/shengmai-san-derived-herbal-prevents-the-development-of-a-vulnerable-substrate-for-atrial-fibrillation-in-a-rat-model-of-ischemic-heart-failure
#16
Jin Ma, Shiyu Ma, Chunxia Yin, Huanlin Wu
OBJECTIVE: The study aimed to investigate whether a Shengmai San-derived herbal, Fumai granule (FM), which had a preventive effect on atrial fibrillation (AF) in myocardial infarction (MI)-induced heart failure (HF) rat and to determine the underlying mechanisms. DESIGN AND METHODS: MI was induced by a ligation of the left anterior descending coronary artery. One week after MI surgery, FM was gavaged for 4 weeks. AF inducibility was detected by transesophageal programmed electrical stimulation technology...
April 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29426889/sio-2-nanoparticles-modulate-the-electrical-activity-of-neuroendocrine-cells-without-exerting-genomic-effects
#17
C Distasi, F A Ruffinatti, M Dionisi, S Antoniotti, A Gilardino, G Croci, B Riva, E Bassino, G Alberto, E Castroflorio, D Incarnato, E Morandi, G Martra, S Oliviero, L Munaron, D Lovisolo
Engineered silica nanoparticles (NPs) have attracted increasing interest in several applications, and particularly in the field of nanomedicine, thanks to the high biocompatibility of this material. For their optimal and controlled use, the understanding of the mechanisms elicited by their interaction with the biological target is a prerequisite, especially when dealing with cells particularly vulnerable to environmental stimuli like neurons. Here we have combined different electrophysiological approaches (both at the single cell and at the population level) with a genomic screening in order to analyze, in GT1-7 neuroendocrine cells, the impact of SiO2 NPs (50 ± 3 nm in diameter) on electrical activity and gene expression, providing a detailed analysis of the impact of a nanoparticle on neuronal excitability...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29377795/statistically-reconstructed-multiplexing-for-very-dense-high-channel-count-acquisition-systems
#18
David Tsai, Rafael Yuste, Kenneth L Shepard
Multiplexing is an important strategy in multichannel acquisition systems. The per-channel antialiasing filters needed in the traditional multiplexing architecture limit its scalability for applications requiring high channel density, high channel count, and low noise. A particularly challenging example is multielectrode arrays for recording from neural systems. We show that conventional approaches must tradeoff recording density and noise performance, at a scale far from the ideal goal of one-to-one mapping between neurons and sensors...
February 2018: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/29372259/lycium-barbarum-polysaccharides-protect-retina-in-rd1-mice-during-photoreceptor-degeneration
#19
Feng Liu, Jia Zhang, Zongqin Xiang, Di Xu, Kwok-Fai So, Noga Vardi, Ying Xu
Purpose: As an active component in wolfberry, lycium barbarum polysaccharides (LBP) are capable of protecting retinal neurons in several animal disease models. Here, we asked whether LBP rescues the retinal morphology and function in rd1 mouse, a photoreceptor fast-degenerating animal model of retinitis pigmentosa, and in particular focused on LBP's effects on the function of retinal ganglion cells (RGCs) during photoreceptor degeneration. Methods: An equal volume of LBP or control vehicle was daily intraperitoneal (i...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29351358/microfluidics-based-subretinal-chemical-neuromodulation-of-photoreceptor-degenerated-retinas
#20
Corey M Rountree, John B Troy, Laxman Saggere
Purpose: Retinal prostheses can restore rudimentary vision in cases of photoreceptor degeneration through electrical stimulation, but face difficulties achieving high spatial resolution because electrical current is an inherently unnatural stimulus. We investigated the therapeutic feasibility of using patterned delivery of the glutamate neurotransmitter, a primary agent of natural synaptic communication of the retina, as a biomimetic chemical alternative to electrical current for neuromodulation of photoreceptor degenerate retina...
January 1, 2018: Investigative Ophthalmology & Visual Science
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