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Multielectrode array

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https://www.readbyqxmd.com/read/27819256/long-term-stability-of-intracortical-recordings-using-perforated-and-arrayed-parylene-sheath-electrodes
#1
Seth A Hara, Brian J Kim, Jonathan T W Kuo, Curtis D Lee, Ellis Meng, Victor Pikov
OBJECTIVE: Acquisition of reliable and robust neural recordings with intracortical neural probes is a persistent challenge in the field of neuroprosthetics. We developed a multielectrode array technology to address chronic intracortical recording reliability and present in vivo recording results. APPROACH: The 2 × 2 Parylene sheath electrode array (PSEA) was microfabricated and constructed from only Parylene C and platinum. The probe includes a novel three-dimensional sheath structure, perforations, and bioactive coatings that improve tissue integration and manage immune response...
December 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27726011/analysis-of-spontaneous-activity-of-superficial-dorsal-horn-neurons-in-vitro-neuropathy-induced-changes
#2
Carolina Roza, Irene Mazo, Iván Rivera-Arconada, Elsa Cisneros, Ismel Alayón, José A López-García
The superficial dorsal horn contains large numbers of interneurons which process afferent and descending information to generate the spinal nociceptive message. Here, we set out to evaluate whether adjustments in patterns and/or temporal correlation of spontaneous discharges of these neurons are involved in the generation of central sensitization caused by peripheral nerve damage. Multielectrode arrays were used to record from discrete groups of such neurons in slices from control or nerve damaged mice. Whole-cell recordings of individual neurons were also obtained...
October 10, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27703279/an-electrically-resistive-sheet-of-glial-cells-for-amplifying-signals-of-neuronal-extracellular-recordings
#3
R Matsumura, H Yamamoto, M Niwano, A Hirano-Iwata
Electrical signals of neuronal cells can be recorded non-invasively and with a high degree of temporal resolution using multielectrode arrays (MEAs). However, signals that are recorded with these devices are small, usually 0.01%-0.1% of intracellular recordings. Here, we show that the amplitude of neuronal signals recorded with MEA devices can be amplified by covering neuronal networks with an electrically resistive sheet. The resistive sheet used in this study is a monolayer of glial cells, supportive cells in the brain...
January 11, 2016: Applied Physics Letters
https://www.readbyqxmd.com/read/27659846/15-th-annual-meeting-of-the-safety-pharmacology-society-focus-on-traditional-sensory-systems
#4
Icilio Cavero, Henry Holzgrefe
INTRODUCTION: This report summarizes and comments key talks on the five traditional senses (ear, vestibular system, vision, taste, olfaction, and touch) which were delivered during the 2015 Annual Meeting of the Safety Pharmacology (SP) Society. AREAS COVERED: The functional observational battery (FOB) can detect major candidate drug liabilities only on ear, touch and vision. Anatomy, physiology, pharmacology, and pathology notions on each sensory system introduce speaker talks...
September 19, 2016: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/27634341/electrophysiological-approaches-to-unravel-the-neurobiological-basis-of-appetite-and-satiety-use-of-the-multielectrode-array-as-a-screening-strategy
#5
Hamdy Shaban, Rory O'Connor, Saak V Ovsepian, Timothy G Dinan, John F Cryan, Harriët Schellekens
Hypothalamic neural circuits are recognised as primary sites of the neuromodulator effect of homeostatic food intake, whereas changes in ventral tegmental area (VTA), hippocampus and amygdala have been implicated in the hedonic, cognitive and emotional aspects of eating. Here, we discuss synaptic transmission and plasticity within brain circuits governing appetite and food intake behaviour, focusing on the metabolic hormones ghrelin and leptin. We discuss functional changes within these circuitries and critically assess the applicability of electrophysiological measurements using in vitro multielectrode array (MEA) systems to identify novel appetite modulators...
September 12, 2016: Drug Discovery Today
https://www.readbyqxmd.com/read/27615033/first-and-second-generation-antipsychotics-differentially-affect-structural-and-functional-properties-of-rat-hippocampal-neuron-synapses
#6
Christine Gottschling, Maren Geissler, Gianna Springer, Rainer Wolf, Georg Juckel, Andreas Faissner
The therapy of patients suffering the psychiatric disorder schizophrenia requires the usage of antipsychotic drugs that are classified into two different groups, the first-generation (FGAs) and the second-generation antipsychotics (SGAs). This study compares the effects of the two FGAs haloperidol and flupentixol with those of the SGA olanzapine on synapse formation and synaptic activity of embryonic rat hippocampal neurons. To this end, the development of perineuronal nets (PNNs), the formation of synapses and the resulting spontaneous network activity under control and treatment conditions were studied using an indirect co-culture system of neurons and astrocytes in completely defined media...
September 8, 2016: Neuroscience
https://www.readbyqxmd.com/read/27599023/topographic-quantification-of-the-transcorneal-electrical-stimulation-tes-induced-protective-effects-on-n-methyl-n-nitrosourea-treated-retinas
#7
Ye Tao, Tao Chen, Zhong-Yu Liu, Li-Qiang Wang, Wei-Wei Xu, Li-Min Qin, Guang-Hua Peng, Huang Yi-Fei
PURPOSE: To quantify the transcorneal electrical stimulation (TES)-induced effects on regional photoreceptors and visual signal pathway of N-methyl-N-nitrosourea (MNU)-treated retinas via topographic measurements. METHODS: N-methyl-N-nitrosourea-administered mice received TES or sham stimulations and were subsequently subjected to electroretinography (ERG), multielectrode array (MEA), and histologic and immunohistochemistry examinations. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analyses were also performed to determine the mRNA levels of Bax, Bcl-2, Calpain-2, Caspase-3, brain-derived neurotrophic factor (BDNF), and ciliary neurotrophic factor (CNTF)...
September 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27581463/selective-vulnerability-of-specific-retinal-ganglion-cell-types-and-synapses-after-transient-ocular-hypertension
#8
Yvonne Ou, Rebecca E Jo, Erik M Ullian, Rachel O L Wong, Luca Della Santina
UNLABELLED: Key issues concerning ganglion cell type-specific loss and synaptic changes in animal models of experimental glaucoma remain highly debated. Importantly, changes in the structure and function of various RGC types that occur early, within 14 d after acute, transient intraocular pressure elevation, have not been previously assessed. Using biolistic transfection of individual RGCs and multielectrode array recordings to measure light responses in mice, we examined the effects of laser-induced ocular hypertension on the structure and function of a subset of RGCs...
August 31, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27578493/interaction-of-intrinsic-and-synaptic-currents-mediate-network-resonance-driven-by-layer-v-pyramidal-cells
#9
Stephen L Schmidt, Christopher R Dorsett, Apoorva K Iyengar, Flavio Fröhlich
Cortical oscillations modulate cellular excitability and facilitate neuronal communication and information processing. Layer 5 pyramidal cells (L5 PYs) drive low-frequency oscillations (<4 Hz) in neocortical networks in vivo. In vitro, individual L5 PYs exhibit subthreshold resonance in the theta band (4-8 Hz). This bandpass filtering of periodic input is mediated by h-current (Ih) and m-current (IM) that selectively suppress low-frequency input. It has remained unclear how these intrinsic properties of cells contribute to the emergent, network oscillation dynamics...
August 30, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27535370/large-scale-recording-of-thalamocortical-circuits-in-vivo-electrophysiology-with-the-two-dimensional-electronic-depth-control-silicon-probe
#10
Richárd Fiáth, Patrícia Beregszászi, Domonkos Horváth, Lucia Wittner, Arno A A Aarts, Patrick Ruther, Hercules P Neves, Hajnalka Bokor, László Acsády, István Ulbert
Recording simultaneous activity of a large number of neurons in distributed neuronal networks is crucial to understand higher order brain functions. We demonstrate the in vivo performance of a recently developed electrophysiological recording system comprising a two-dimensional, multi-shank, high-density silicon probe with integrated complementary metal-oxide semiconductor electronics. The system implements the concept of electronic depth control (EDC), which enables the electronic selection of a limited number of recording sites on each of the probe shafts...
November 1, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27465511/prolonged-stimulation-with-low-intensity-ultrasound-induces-delayed-increases-in-spontaneous-hippocampal-culture-spiking-activity
#11
Hyun-Bum Kim, Kelley M Swanberg, Hee-Sok Han, Jung-Chae Kim, Jun-Woo Kim, Sungon Lee, C Justin Lee, Sungho Maeng, Tae-Seong Kim, Ji-Ho Park
Ultrasound is a promising neural stimulation modality, but an incomplete understanding of its range and mechanism of effect limits its therapeutic application. We investigated the modulation of spontaneous hippocampal spike activity by ultrasound at a lower acoustic intensity and longer time scale than has been previously attempted, hypothesizing that spiking would change conditionally upon the availability of glutamate receptors. Using a 60-channel multielectrode array (MEA), we measured spontaneous spiking across organotypic rat hippocampal slice cultures (N = 28) for 3 min each before, during, and after stimulation with low-intensity unfocused pulsed or sham ultrasound (spatial-peak pulse average intensity 780 μW/cm(2) ) preperfused with artificial cerebrospinal fluid, 300 μM kynurenic acid (KA), or 0...
July 28, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27413160/nav1-7-a1632g-mutation-from-a-family-with-inherited-erythromelalgia-enhanced-firing-of-dorsal-root-ganglia-neurons-evoked-by-thermal-stimuli
#12
Yang Yang, Jianying Huang, Malgorzata A Mis, Mark Estacion, Lawrence Macala, Palak Shah, Betsy R Schulman, Daniel B Horton, Sulayman D Dib-Hajj, Stephen G Waxman
UNLABELLED: Voltage-gated sodium channel Nav1.7 is a central player in human pain. Mutations in Nav1.7 produce several pain syndromes, including inherited erythromelalgia (IEM), a disorder in which gain-of-function mutations render dorsal root ganglia (DRG) neurons hyperexcitable. Although patients with IEM suffer from episodes of intense burning pain triggered by warmth, the effects of increased temperature on DRG neurons expressing mutant Nav1.7 channels have not been well documented...
July 13, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27376596/microelectrode-arrays-of-diamond-insulated-graphitic-channels-for-real-time-detection-of-exocytotic-events-from-cultured-chromaffin-cells-and-slices-of-adrenal-glands
#13
Federico Picollo, Alfio Battiato, Ettore Bernardi, Andrea Marcantoni, Alberto Pasquarelli, Emilio Carbone, Paolo Olivero, Valentina Carabelli
A microstructured graphitic 4 × 4 multielectrode array was embedded in a single-crystal diamond substrate (4 × 4 μG-SCD MEA) for real-time monitoring of exocytotic events from cultured chromaffin cells and adrenal slices. The current approach relies on the development of a parallel ion beam lithographic technique, which assures the time-effective fabrication of extended arrays with reproducible electrode dimensions. The reported device is suitable for performing amperometric and voltammetric recordings with high sensitivity and temporal resolution, by simultaneously acquiring data from 16 rectangularly shaped microelectrodes (20 × 3...
August 2, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27351032/long-term-non-invasive-interrogation-of-human-dorsal-root-ganglion-neuronal-cultures-on-an-integrated-microfluidic-multielectrode-array-platform
#14
H A Enright, S H Felix, N O Fischer, E V Mukerjee, D Soscia, M Mcnerney, K Kulp, J Zhang, G Page, P Miller, A Ghetti, E K Wheeler, S Pannu
Scientific studies in drug development and toxicology rely heavily on animal models, which often inaccurately predict the true response for human exposure. This may lead to unanticipated adverse effects or misidentified risks that result in, for example, drug candidate elimination. The utilization of human cells and tissues for in vitro physiological platforms has become a growing area of interest to bridge this gap and to more accurately predict human responses to drugs and toxins. The effects of new drugs and toxins on the peripheral nervous system are often investigated with neurons isolated from dorsal root ganglia (DRG), typically with one-time measurement techniques such as patch clamping...
September 21, 2016: Analyst
https://www.readbyqxmd.com/read/27337709/a-high-performance-neural-prosthesis-incorporating-discrete-state-selection-with-hidden-markov-models
#15
Jonathan C Kao, Paul Nuyujukian, Stephen I Ryu, Krishna V Shenoy
Communication neural prostheses aim to restore efficient communication to people with motor neurological injury or disease by decoding neural activity into control signals. These control signals are both analog (e.g., the velocity of a computer mouse) and discrete (e.g., clicking an icon with a computer mouse) in nature. Effective, high-performing, and intuitive-to-use communication prostheses should be capable of decoding both analog and discrete state variables seamlessly. However, to date, the highest-performing autonomous communication prostheses rely on precise analog decoding, and typically do not incorporate highperformance discrete decoding...
June 21, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27306334/knockdown-of-dna-methyltransferase-3a-alters-gene-expression-and-inhibits-function-of-embryonic-cardiomyocytes
#16
Xiefan Fang, Ryan R Poulsen, John Wang-Hu, Olivia Shi, Nicholas S Calvo, Chelsey S Simmons, Scott A Rivkees, Christopher C Wendler
We previously found that in utero caffeine exposure causes down-regulation of DNA methyltransferases (DNMTs) in embryonic heart and results in impaired cardiac function in adulthood. To assess the role of DNMTs in these events, we investigated the effects of reduced DNMT expression on embryonic cardiomyocytes. siRNAs were used to knock down individual DNMT expression in primary cultures of mouse embryonic cardiomyocytes. Immunofluorescence staining was conducted to evaluate cell morphology. A video-based imaging assay and multielectrode array were used to assess cardiomyocyte contractility and electrophysiology, respectively...
September 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27301998/characterisation-of-light-responses-in-the-retina-of-mice-lacking-principle-components-of-rod-cone-and-melanopsin-phototransduction-signalling-pathways
#17
Steven Hughes, Jessica Rodgers, Doron Hickey, Russell G Foster, Stuart N Peirson, Mark W Hankins
Gnat(-/-), Cnga3(-/-), Opn4(-/-) triple knockout (TKO) mice lack essential components of phototransduction signalling pathways present in rods, cones and photosensitive retinal ganglion cells (pRGCs), and are therefore expected to lack all sensitivity to light. However, a number of studies have shown that light responses persist in these mice. In this study we use multielectrode array (MEA) recordings and light-induced c-fos expression to further characterise the light responses of the TKO retina. Small, but robust electroretinogram type responses are routinely detected during MEA recordings, with properties consistent with rod driven responses...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27298627/esp-102-a-combined-herbal-extract-of-angelica-gigas-saururus-chinensis-and-schisandra-chinensis-changes-synaptic-plasticity-and-attenuates-scopolamine-induced-memory-impairment-in-rat-hippocampus-tissue
#18
Hyun-Bum Kim, Eun-Sang Hwang, Ga-Young Choi, Seok Lee, Tae-Suk Park, Cheol-Won Lee, Eun-Suk Lee, Young-Choong Kim, Sang Seong Kim, Sung-Ok Lee, Ji-Ho Park
ESP-102, an extract from Angelica gigas, Saururus chinensis, and Schisandra chinensis, has been used as herbal medicine and dietary supplement in Korea. Despite the numerous bioactivities in vitro and in vivo studies, its effects on neuronal networks remain elusive. To address the neuronal effect, we examined synaptic plasticity in organotypic hippocampal slice culture with multielectrode array. Our results showed an increase in excitatory postsynaptic potential (EPSP), indicating the induction of long-term potentiation (LTP), in the presence of ESP-102...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27275008/rank-order-coding-a-retinal-information-decoding-strategy-revealed-by-large-scale-multielectrode-array-retinal-recordings
#19
Geoffrey Portelli, John M Barrett, Gerrit Hilgen, Timothée Masquelier, Alessandro Maccione, Stefano Di Marco, Luca Berdondini, Pierre Kornprobst, Evelyne Sernagor
How a population of retinal ganglion cells (RGCs) encodes the visual scene remains an open question. Going beyond individual RGC coding strategies, results in salamander suggest that the relative latencies of a RGC pair encode spatial information. Thus, a population code based on this concerted spiking could be a powerful mechanism to transmit visual information rapidly and efficiently. Here, we tested this hypothesis in mouse by recording simultaneous light-evoked responses from hundreds of RGCs, at pan-retinal level, using a new generation of large-scale, high-density multielectrode array consisting of 4096 electrodes...
May 2016: ENeuro
https://www.readbyqxmd.com/read/27217825/spike-code-flow-in-cultured-neuronal-networks
#20
Shinichi Tamura, Yoshi Nishitani, Chie Hosokawa, Tomomitsu Miyoshi, Hajime Sawai, Takuya Kamimura, Yasushi Yagi, Yuko Mizuno-Matsumoto, Yen-Wei Chen
We observed spike trains produced by one-shot electrical stimulation with 8 × 8 multielectrodes in cultured neuronal networks. Each electrode accepted spikes from several neurons. We extracted the short codes from spike trains and obtained a code spectrum with a nominal time accuracy of 1%. We then constructed code flow maps as movies of the electrode array to observe the code flow of "1101" and "1011," which are typical pseudorandom sequence such as that we often encountered in a literature and our experiments...
2016: Computational Intelligence and Neuroscience
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