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https://www.readbyqxmd.com/read/28095442/cardiac-mean-electrical-axis-in-thoroughbreds-standardization-by-the-dubois-lead-positioning-system
#1
Cássia Fré da Costa, Nelson Samesima, Carlos Alberto Pastore
BACKGROUND: Different methodologies for electrocardiographic acquisition in horses have been used since the first ECG recordings in equines were reported early in the last century. This study aimed to determine the best ECG electrodes positioning method and the most reliable calculation of mean cardiac axis (MEA) in equines. MATERIALS AND METHODS: We evaluated the electrocardiographic profile of 53 clinically healthy Thoroughbreds, 38 males and 15 females, with ages ranging 2-7 years old, all reared at the São Paulo Jockey Club, in Brazil...
2017: PloS One
https://www.readbyqxmd.com/read/28073536/microelectrode-array-mea-platform-as-a-sensitive-tool-to-detect-and-evaluate-ostreopsis-cf-ovata-toxicity
#2
Susanna Alloisio, Valentina Giussani, Mario Nobile, Mariachiara Chiantore, Antonio Novellino
In the last decade, the occurrence of harmful dinoflagellate blooms of the genus Ostreopsis has increased both in frequency and in geographic distribution with adverse impacts on public health and the economy. Ostreopsis species are producers of palytoxin-like toxins (putative palytoxin and ovatoxins) which are among the most potent natural non-protein compounds known to date, exhibiting extreme toxicity in mammals, including humans. Most existing toxicological data are derived from in vivo mouse assay and are related to acute effects of pure palytoxin, without considering that the toxicity mechanism of dinoflagellates can be dependent on the varying composition of complex biotoxins mixture and on the presence of cellular components...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28067094/the-use-of-regression-analysis-in-determining-reference-intervals-for-low-hematocrit-and-thrombocyte-count-in-multiple-electrode-aggregometry-and-platelet-function-analyzer-100-testing-of-platelet-function
#3
Gerhardus J A J M Kuiper, Rik Houben, Rick J H Wetzels, Paul W M Verhezen, Rene van Oerle, Hugo Ten Cate, Yvonne M C Henskens, Marcus D Lancé
Low platelet counts and hematocrit levels hinder whole blood point-of-care testing of platelet function. Thus far, no reference ranges for MEA (multiple electrode aggregometry) and PFA-100 (platelet function analyzer 100) devices exist for low ranges. Through dilution methods of volunteer whole blood, platelet function at low ranges of platelet count and hematocrit levels was assessed on MEA for four agonists and for PFA-100 in two cartridges. Using (multiple) regression analysis, 95% reference intervals were computed for these low ranges...
January 9, 2017: Platelets
https://www.readbyqxmd.com/read/28064422/improved-detection-of-mineral-oil-toxicity-using-an-extended-mouse-embryo-assay
#4
Alessandra J Ainsworth, Jolene R Fredrickson, Dean E Morbeck
PURPOSE: Successful in vitro fertilization (IVF) relies on sound laboratory methods and culture conditions which depend on sensitive quality control (QC) testing. This study aimed to improve the sensitivity of mouse embryo assays (MEA) for detection of mineral oil toxicity. METHODS: Five experiments were conducted to study modifications of the standard mouse embryo assay (MEA) in order to improve sensitivity using clinical grade mineral oil with known peroxide concentrations...
January 7, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28049523/safety-of-a-fixed-dose-combination-of-artesunate-and-amodiaquine-for-the-treatment-of-uncomplicated-plasmodium-falciparum-malaria-in-real-life-conditions-of-use-in-c%C3%A3-te-d-ivoire
#5
Serge-Brice Assi, Yapo Thomas Aba, Jean Claude Yavo, Abouo Franklin Nguessan, N'cho Bertin Tchiekoi, Koffi Moïse San, Emmanuel Bissagnéné, Stephan Duparc, Valérie Lameyre, Mea Antoine Tanoh
BACKGROUND: In many malaria-endemic, sub-Saharan African countries, existing pharmacovigilance systems are not sufficiently operational to document reliably the safety profile of anti-malarial drugs. This study describes the implantation of a community-based pharmacovigilance system in Côte d'Ivoire and its use to document the safety of ASAQ Winthrop(®) (artesunate-amodiaquine). METHODS: This prospective, longitudinal, descriptive, non-comparative, non-interventional study on the use of artesunate-amodiaquine in real-life conditions of use was conducted in seven Community Health Centres of the Agboville district in Côte d'Ivoire...
January 3, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28045002/topographic-prominence-discriminator-for-the-detection-of-short-latency-spikes-of-retinal-ganglion-cells
#6
Myoung-Hwan Choi, Jungryul Ahn, Daejin Park, Sang Min Lee, Kwangsoo Kim, Dong-Il Cho, Solomon Senok, Kyo-In Koo, Yongsook Goo
<i>Objective</i>: Direct stimulation of retinal ganglion cells in degenerate retinas by implanting epi-retinal prostheses is a recognized strategy for restoration of visual perception in patients with retinitis pigmentosa or age-related macular degeneration. Elucidating the best stimulus-response paradigms in the laboratory using multielectrode arrays (MEA) is complicated by the fact that the short-latency spikes (within 10 ms) elicited by direct retinal ganglion cell (RGC) stimulation are obscured by the stimulus artifact which is generated by the electrical stimulator...
January 3, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28042814/in-situ-real-time-monitoring-of-glutamate-and-electrophysiology-from-cortex-to-hippocampus-in-mice-based-on-a-microelectrode-array
#7
Xinyi Fan, Yilin Song, Yuanlin Ma, Song Zhang, Guihua Xiao, Lili Yang, Huiren Xu, Dai Zhang, Xinxia Cai
Changes in the structure and function of the hippocampus contribute to epilepsy, schizophrenia and other neurological or mental disorders of the brain. Since the function of the hippocampus depends heavily on the glutamate (Glu) signaling pathways, in situ real-time detection of Glu neurotransmitter release and electrophysiological signals in hippocampus is of great significance. To achieve the dual-mode detection in mouse hippocampus in vivo, a 16-channel implantable microelectrode array (MEA) was fabricated by micro-electromechanical system (MEMS) technology...
December 30, 2016: Sensors
https://www.readbyqxmd.com/read/28027545/social-and-psychological-state-of-the-chornobyl-clean-up-workers-risk-factors-for-negative-changes
#8
V O Buzunov, K N Loganovsky, L I Krasnikova, M O Bomko, Yu M Belyaev, Zh S Yaroshenko, T Ye Domashevska
: It is generally recognized that the Chornobyl nuclear accident caused strong psychosocial stress affecting the entire population of Ukraine, primarily people involved in recovery operations. But what are the reasons? What is the struc ture of stressors? What are their social, medical and biological consequences, what are strategy and preventive meas ures? Issues that require special research and development. OBJECTIVE: To study social and psychological state of the Chornobyl cleanup workers 1986-1987, and to determine regularities of changes and dangerous risk factors...
December 2016: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/28027435/planar-diamond-based-multiarrays-to-monitor-neurotransmitter-release-and-action-potential-firing-new-perspectives-in-cellular-neuroscience
#9
Valentina Carabelli, Andrea Marcantoni, Federico Picollo, Alfio Battiato, Ettore Bernardi, Alberto Pasquarelli, Paolo Olivero, Emilio Carbone
High biocompatibility, outstanding electrochemical responsiveness, inertness and transparency make diamond-based multiarrays (DBMs) first-rate biosensors for in vitro detection of electrochemical and electrical signals from excitable cells together, with potential for in vivo applications as neural interfaces and prostheses. Here, we will review the electrochemical and physical properties of various DBMs and how these devices have been employed for recording released neurotransmitter molecules and all-or-none action potentials from living cells...
December 27, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28025552/solvation-dynamics-of-co%C3%A2-g-by-monoethanolamine-at-the-gas-liquid-interface-a-molecular-mechanics-approach
#10
I-Shou Huang, Jia-Jen Li, Ming-Kang Tsai
A classical force field approach was used to characterize the solvation dynamics of high-density CO₂(g) by monoethanolamine (MEA) at the air-liquid interface. Intra- and intermolecular CO₂ and MEA potentials were parameterized according to the energetics calculated at the MP2 and BLYP-D2 levels of theory. The thermodynamic properties of CO₂ and MEA, such as heat capacity and melting point, were consistently predicted using this classical potential. An approximate interfacial simulation for CO₂(g)/MEA(l) was performed to monitor the depletion of the CO₂(g) phase, which was influenced by amino and hydroxyl groups of MEA...
December 23, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28008963/characterization-of-dorsal-root-ganglion-neurons-cultured-on-silicon-micro-pillar-substrates
#11
Tihana Repić, Katarina Madirazza, Ezgi Bektur, Damir Sapunar
Our study focuses on characterization of dorsal root ganglion (DRG) neurons cultured on silicon micro-pillar substrates (MPS) with the ultimate goal of designing micro-electrode arrays (MEAs) for successful electrophysiological recordings of DRG neurons. Adult and neonatal DRG neurons were cultured on MPS and glass coverslips for 7 days in vitro. DRG neuronal distribution and morphometric analysis, including neurite alignment and length, was performed on MPS areas with different pillar width and spacing. We showed that MPS provide an environment for growth of adult and neonatal DRG neurons as permissive as control glass surfaces...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28006672/gene-electrotransfer-into-skin-using-noninvasive-multi-electrode-array-for-vaccination-and-wound-healing
#12
Spela Kos, Kevin Vanvarenberg, Tanja Dolinsek, Maja Cemazar, Jure Jelenc, Véronique Préat, Gregor Sersa, Gaëlle Vandermeulen
Skin is an attractive target for gene electrotransfer due to its easy accessibility and its interesting immune properties. Since electrodes are often invasive and frequently induce discomfort during pulse application, there is a fundamental need for non-invasive electrodes for skin delivery. We developed circular pin non-invasive multi-electrode array (MEA), suitable for different clinical applications. MEA was first employed to deliver a luciferase reporter gene. Then, it was used to deliver a DNA vaccine coding for ovalbumin or a plasmid encoding hCAP-18/LL-37 for promoting wound healing...
December 10, 2016: Bioelectrochemistry
https://www.readbyqxmd.com/read/28005434/a-feasibility-study-on-smartphone-accelerometer-based-recognition-of-household-activities-and-influence-of-smartphone-position
#13
Vincenzo Della Mea, Omar Quattrin, Maria Parpinel
BACKGROUND: Obesity and physical inactivity are the most important risk factors for chronic diseases. The present study aimed at (i) developing and testing a method for classifying household activities based on a smartphone accelerometer; (ii) evaluating the influence of smartphone position; and (iii) evaluating the acceptability of wearing a smartphone for activity recognition. METHODS: An Android application was developed to record accelerometer data and calculate descriptive features on 5-second time blocks, then classified with nine algorithms...
December 22, 2016: Informatics for Health & Social Care
https://www.readbyqxmd.com/read/27984791/does-economic-financial-and-institutional-developments-matter-for-environmental-quality-a-comparative-analysis-of-eu-and-mea-countries
#14
Mehdi Abid
The aim of this study is to test the hypothesis of the Environmental Kuznets Curve (EKC) with a sample of 58 MEA (Middle East & African) and 41 EU (European Union) countries for the period 1990 to 2011. The empirical analysis is carried out using the GMM-system method to solve the problem of endogenous variables. We focused on direct and indirect effects of institutional quality (through the efficiency of public expenditure, financial development, trade openness and foreign direct investment) and the income-emission relationship...
March 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/27984182/contribution-of-nav1-8-sodium-channels-to-retinal-function
#15
Benjamin J Smith, Patrice D Côté, François Tremblay
We examined the contribution of the sodium channel isoform Nav1.8 to retinal function using the specific blocker A803467. We found that A803467 has little influence on the electroretinographic (ERG) a- and b-waves, but significantly reduces the oscillatory potentials to 40-60% of their original amplitude, with significant changes in implicit time in the rod-driven range. To date, only two cell types were found in mouse to express Nav1.8; the starburst amacrine cells (SBAC), and a subtype of retinal ganglion cells (RGC)...
October 28, 2016: Neuroscience
https://www.readbyqxmd.com/read/27981240/genomewide-dam-methylation-in-escherichia-coli-during-long-term-stationary-phase
#16
Lacey L Westphal, Peter Sauvey, Matthew M Champion, Ian M Ehrenreich, Steven E Finkel
DNA methylation in prokaryotes is widespread. The most common modification of the genome is the methylation of adenine at the N-6 position. In Escherichia coli K-12 and many gammaproteobacteria, this modification is catalyzed by DNA adenine methyltransferase (Dam) at the GATC consensus sequence and is known to modulate cellular processes including transcriptional regulation of gene expression, initiation of chromosomal replication, and DNA mismatch repair. While studies thus far have focused on the motifs associated with methylated adenine (meA), the frequency of meA across the genome, and temporal dynamics during early periods of incubation, here we conduct the first study on the temporal dynamics of adenine methylation in E...
November 2016: MSystems
https://www.readbyqxmd.com/read/27976520/photoelectrochemical-conversion-of-toluene-and-water-to-the-promising-hydrogen-carrier-of-concentrated-methylcyclohexane-using-srtio3-photoanodes
#17
Yosuke Kageshima, Tsutomu Minegishi, Takashi Hisatomi, Tsuyoshi Takata, Jun Kubota, Kazunari Domen
A photoelectrochemical (PEC) cell consisting of a Pt-loaded carbon black (Pt/C)-based membrane-electrode assembly (MEA) and a particulate SrTiO3 photoanode successfully demonstrated selective PEC conversion of toluene (TL) and water to methylcyclohexane (MCH) at concentrations up to >99 vol%. This cell exhibited 100% faradaic efficiency (FE) and 18% incident-photon-to-current conversion efficiency (IPCE) at 320 nm without an external bias voltage in the PEC hydrogenation of pure TL. It was also found that the strong alkaline condition is beneficial for present MEA to suppress the competitive side reaction of hydrogen evolution, resulting in a high FE of 94% even during MCH production from 1 vol% TL in MCH...
December 14, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27974974/musical-electroacupuncture-may-be-a-better-choice-than-electroacupuncture-in-a-mouse-model-of-alzheimer-s-disease
#18
Jing Jiang, Gang Liu, Suhua Shi, Zhigang Li
Objectives. To compare musical electroacupuncture and electroacupuncture in a mouse model of Alzheimer's disease. Methods. In this study, 7.5-month-old male senescence-accelerated mouse prone 8 (SAMP8) mice were used as an Alzheimer's disease animal model. In the normal control paradigm, 7.5-month-old male SAMR1 mice were used as the blank control group (N group). After 15 days of treatment, using Morris water maze test, micro-PET, and immunohistochemistry, the differences among the musical electroacupuncture (MEA), electroacupuncture (EA), Alzheimer's disease (AD), and normal (N) groups were assessed...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/27974450/coupling-multi-electrode-array-recordings-with-silver-labeling-of-recording-sites-to-study-cervical-spinal-network-connectivity
#19
Kristi A Streeter, Michael D Sunshine, Shreya R Patel, Savannah S Liddell, Lucy E Denholtz, Paul J Reier, David D Fuller, David M Baekey
Mid-cervical spinal interneurons form a complex and diffuse network and may be involved in modulating phrenic motor output. The intent of the current work was to enable a better understanding of mid-cervical "network level" connectivity by pairing the neurophysiological multi-electrode array (MEA) data with histological verification of the recording locations. We first developed a method to deliver 100 nA currents to electroplate silver onto and subsequently deposit silver from electrode tips after obtaining mid-cervical (C3-5) recordings using an MEA in anesthetized and ventilated adult rats...
December 14, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27966955/physical-absorption-of-green-house-gases-in-amines-the-influence-of-functionality-structure-and-cross-interactions
#20
Gustavo A Orozco, Véronique Lachet, Allan D Mackie
Monte Carlo simulations were performed in the isothermal-isobaric ensemble (NPT) to calculate the Henry constants of methane (CH4), nitrous oxide (N2O), and carbon dioxide (CO2) in pure H2O, amines, and alkanolamines using the classical Lorentz-Berthelot combining rules (L-B). The Henry constants of N2O and CO2 in water are highly overestimated and motivated us to propose a new set of unlike interactions. Contrarily, the Henry constant of N2O in MEA is underestimated by around 40%, and again, a new reoptimized cross unlike parameter is able to reproduce the constant to within 10%...
December 29, 2016: Journal of Physical Chemistry. B
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