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Leandro Bueno Lima, Fernanda Tais Haubenthal, Marina Augusto Silveira, Tabata Mariz Bohlen, Martin Metzger, Jose Donato, Renata Frazao
A small neuronal subpopulation in the medial nucleus of the amygdala (MeA), expressing the Kiss1 gene, is now considered an important mediator that integrates socio-sexual behavior and odor information in order to modulate the Hypothalamic-Pituitary-Gonadal (HPG) axis. Previous studies demonstrated that exogenous kisspeptin administration or selective activation of Kiss1-expressing neurons in the MeA modulates the onset of puberty, LH secretion and sexual behavior. These functions are supported by the known MeA neuronal connections...
May 14, 2018: Neuroscience Letters
Abdenacer Idrissi, Pal Jedlovszky
The volume, energy, entropy, and Helmholtz free energy of mixing of the seven simplest primary alkanolamine molecules, i.e., MEA, MIPA, 2A1P, ABU, AMP, AMP2, and 1A2B with water is investigated by extensive computer simulations and thermodynamic integration. To check the force field dependence of the results, all calculations are repeated with two commonly used water models, namely SPC/E and TIP4P. The obtained results show that the thermodynamics of mixing of alkanolamines and water is largely independent from the type of the alkanolamine molecule...
May 17, 2018: Journal of Physical Chemistry. B
Karla R Sanchez, Mahlet D Mersha, Harbinder S Dhillon, Murali K Temburni
Bis-phenols, such as bis-phenol A (BPA) and bis-phenol-S (BPS), are polymerizing agents widely used in the production of plastics and numerous everyday products. They are classified as endocrine disrupting compounds (EDC) with estradiol-like properties. Long-term exposure to EDCs, even at low doses, has been linked with various health defects including cancer, behavioral disorders, and infertility, with greater vulnerability during early developmental periods. To study the effects of BPA on the development of neuronal function, we used an in vitro neuronal network derived from the early chick embryonic brain as a model...
April 26, 2018: Journal of Visualized Experiments: JoVE
Xiao Feng, Benjamin M Bader, Fan Yang, Monica Segura, Luise Schultz, Olaf H-U Schröder, Arndt Rolfs, Jiankai Luo
Niemann-Pick Type C1 (NPC1) disease is an autosomal recessive neurodegenerative disease characterized by an excessive accumulation of unesterified cholesterol in late endosomes/lysosomes. Patients with NPC1 disease show a series of symptoms in neuropathology, including a gradually increased loss of motor control and seizures. However, mechanism of the neurological manifestations in NPC1 disease is not fully understood yet. In this study, we utilized the micro-electrode array (MEA) to analyze the spontaneous extracellular electrical activity in cultivated cortical neurons of the NPC1 mutant (NPC1-/- ) mouse...
May 10, 2018: Brain Research
Wei Wang, Bin Zheng, Binlin Chen, Yaoming An, Xiaoming Jiang, Zhangyong Li
In recent years, the pollution problem of particulate matter, especially PM2.5, is becoming more and more serious, which has attracted many people's attention from all over the world. In this paper, a Kalman prediction model combined with cubic spline interpolation is proposed, which is applied to predict the concentration of PM2.5 in the micro-regional environment of campus, and to realize interpolation simulation diagram of concentration of PM2.5 and simulate the spatial distribution of PM2.5. The experiment data are based on the environmental information monitoring system which has been set up by our laboratory...
February 1, 2018: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
Peng Li, Chun Yue Li, Yi Quan Wang, Cai Qiang Jiao
This study was conducted to assess the effects of fertilizing regime and orchard planting age on soil calcium contents and stocks in the apple orchards on the Loess Plateau. The apple orchards in Luochuan County, one of the best regions for apple plantation in the world, were selec-ted in this study. The contents of calcium carbonate,water-soluble calcium and exchangeable cal-cium at 0-100 cm soil layer under different fertilizing regimes and various planting ages were mea-sured, their stocks were calculated and their variation features were analyzed...
May 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Yu Jie Niu, Si Wei Yang, Gui Zhen Wang, Li Liu, Li Min Hua
The research selected the plots of six grazing intensities in an alpine meadow in north-eastern Tibet Plateau in four years (2012-2015) and studied the relation between ten species diversity indexes, including two measured indexes (Richness and Abundance) in field and two indexes of each dominance, evenness, richness, integrated indexes, and grazing intensity as well as grazing time aiming at scientific selection of biodiversity index under grazing disturbance. The results indicated that the abundance was a better index than importance value to calculate biodiversity level because it was more sensitive to grazing disturbance...
June 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Bo Wang, Lu Wang, Kai Wang, Fadao Tai
Mothers' brains change dramatically in response to the release of hormones related to pregnancy and labor; however, fathers' brains are also sensitive to the experience of paternal care. Thus, fathers with differing fathering experience may exhibit different behavioral responses towards pups. Using socially monogamous mandarin voles (Microtus mandarinus), effects of fathering experience on levels of paternal behavior as well as oxytocin (OT) and dopamine-2 type (D2) receptors in the nucleus accumbens (NaCC) and medial nucleus of the amygdala (MeA) were investigated...
May 2, 2018: Physiology & Behavior
Xia Wu, Seok Joon Kwon, Domyoung Kim, Jian Zha, Mauricio Mora-Pale, Jonathan S Dordick
Lysostaphin (Lst) is a potent bacteriolytic enzyme that kills Staphylococcus aureus , a common bacterial pathogen of humans and animals. With high activity against both planktonic cells and biofilms, Lst has the potential to be used in industrial products, such as commercial cleansers, for decontamination. However, Lst is inhibited in the presence of monoethanolamine (MEA), a chemical widely used in cleaning solutions and pharmaceuticals, and the underlying mechanism remains unknown. In this study, we examined the cell binding and killing capabilities of Lst against S...
May 4, 2018: Applied and Environmental Microbiology
Carla Viegas, Ricardo Moreira, Tiago Faria, Liliana Aranha Caetano, Elisabete Carolino, Anita Quintal Gomes, Susana Viegas
The frequency and importance of Aspergillus infections is increasing worldwide. This study aimed to assess the occupational exposure of forklifts and taxi drivers to Aspergillus spp. Nineteen filters from air conditioning system of taxis, 17 from forklifts and 37 from personal vehicles were assessed. Filters extract were streaked onto MEA, DG18 and in azole-supplemented media. Real-time quantitative PCR amplification of selected Aspergillus species-complex was also performed. Forklifts filter samples presented higher median values...
May 4, 2018: Archives of Environmental & Occupational Health
Jee Woong Lee, Hongki Kang, Yoonkey Nam
In recent years, photothermal stimulation methods using plasmonic metal nanoparticles have emerged as non-genetic optical techniques in neuromodulation. Although nanoparticle-based photothermal stimulation shows great potential in the excitation and the inhibition of neural activity, the complex synthesis processes of the nanoparticles and the lack of large-area deposition methods can be limiting factors for the development of photothermal neural devices. In this paper, we propose a plasmonic gold nanofilm, fabricated by a standard thermal evaporation process, as a simple and mass-producible photothermal neural interface layer for microelectrode array (MEA) chips...
May 4, 2018: Nanoscale
Shoko Iida, Kenta Shimba, Koji Sakai, Kiyoshi Kotani, Yasuhiko Jimbo
The balance between glutamate-mediated excitation and GABA-mediated inhibition is critical to cortical functioning. However, the contribution of network structure consisting of the both neurons to cortical functioning has not been elucidated. We aimed to evaluate the relationship between the network structure and functional activity patterns in vitro. We used mouse induced pluripotent stem cells (iPSCs) to construct three types of neuronal populations; excitatory-rich (Exc), inhibitory-rich (Inh), and control (Cont)...
April 30, 2018: Biochemical and Biophysical Research Communications
Ziyue Li, Yilin Song, Guihua Xiao, Fei Gao, Shengwei Xu, Mixia Wang, Yu Zhang, Fengru Guo, Jie Liu, Yang Xia, Xinxia Cai
Temporal Lobe Epilepsy (TLE) is a chronic neurological disorder, characterized by sudden, repeated and transient central nervous system dysfunction. For better understanding of TLE, bio-nanomodified microelectrode arrays (MEA) are designed, for the achievement of high-quality simultaneous detection of glutamate signals (Glu) and multi-channel electrophysiological signals including action potentials (spikes) and local field potentials (LFPs). The MEA was fabricated by Micro-Electro-Mechanical System fabrication technology and all recording sites were modified with platinum black nano-particles, the average impedance decreased by nearly 90 times...
April 30, 2018: Analytical Biochemistry
Jordi Cools, Qianru Jin, Eugene Yoon, Diego Alba Burbano, Zhenxiang Luo, Dieter Cuypers, Geert Callewaert, Dries Braeken, David H Gracias
Microelectrode arrays (MEAs) have proved to be useful tools for characterizing electrically active cells such as cardiomyocytes and neurons. While there exist a number of integrated electronic chips for recording from small populations or even single cells, they rely primarily on the interface between the cells and 2D flat electrodes. Here, an approach that utilizes residual stress-based self-folding to create individually addressable multielectrode interfaces that wrap around the cell in 3D and function as an electrical shell-like recording device is described...
April 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Daniel Millard, Qianyu Dang, Hong Shi, Xiaou Zhang, Chris Strock, Udo Kraushaar, Haoyu Zeng, Paul Levesque, Hua-Rong Lu, Jean-Michel Guillon, Joseph C Wu, Yingxin Li, Greg Luerman, Blake Anson, Liang Guo, Mike Clements, Yama A Abassi, James Ross, Jennifer Pierson, Gary Gintant
Recent in vitro cardiac safety studies demonstrate the ability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to detect electrophysiologic effects of drugs. However, variability contributed by unique approaches, procedures, cell lines and reagents across laboratories makes comparisons of results difficult, leading to uncertainty about the role of hiPSC-CMs in defining proarrhythmic risk in drug discovery and regulatory submissions. A blinded pilot study was conducted to evaluate the electrophysiologic effects of eight well-characterized drugs on four cardiomyocyte lines using a standardized protocol across three microelectrode array (MEA) platforms (18 individual studies)...
April 27, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Micha E Spira, Nava Shmoel, Shun-Ho M Huang, Hadas Erez
Multielectrode arrays (MEA) are used extensively for basic and applied electrophysiological research of neuronal- and cardiomyocyte-networks. Whereas immense progress has been made in realizing sophisticated MEA platforms of thousands of addressable, high-density, small diameter, low impedance sensors, the quality of the interfaces formed between excitable cells and classical planar sensor has not improved. As a consequence in vitro and in vivo MEA are "blind" to the rich and important "landscape" of sub-threshold synaptic potentials generated by individual neurons...
2018: Frontiers in Neuroscience
Qiang Liu, Feng Ri Li, Wei Peng
The data of needle in situ maximum net photosynthetic rate (SPn max ) and abscised maximum net photosynthetic rate (APn max ) were measured for the 15 year-old planted Larix olgensis stand in the Maoershan Forest Farm, Heilongjiang Province, China. The change pattern between APn max and abscised time (ta ) was analyzed and the functional relationship between SPn max and APn max with ta was also established. Finally, the prediction model of SPn max for planted L. olgensis trees was developed by analyzing the effect of tree size and environmental factors on the decline of APnmax ...
October 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Marc Donada, Vincenzo Della Mea, Megan Cumerlato, Nicole Rankin, Richard Madden
The International Classification of Health Interventions (ICHI) is a member of the WHO Family of International Classifications, being developed to provide a common tool for reporting and analysing health interventions for statistical purposes. A web-based platform for classification development and update has been specifically developed to support the initial development step and then, after final approval, the continuous revision and update of the classification. The platform provides features for classification editing, versioning, comment management and URI identifiers...
2018: Studies in Health Technology and Informatics
Xiu-Mei Yang, Yue-Xiang Zhao, Zong-Hua Wang, Lu Liu
AIM: To evaluate the effect of intravitreal ranibizumab injection for retinopathy of prematurity (ROP) in Zone II Stage 3+ . METHODS: Data was collected for ROP patients with Zone II Stage 3+ who received intravitreal ranibizumab injections between October 2014 and Janu-ary 2017 at the Department of Ophthalmology in our hospital. No prior laser or other intravitreal treatment was done. Prior to the intervention and at each follow-up visit, fundus examination was performed...
2018: International Journal of Ophthalmology
Linoy Mia Frankiensztajn, Rotem Gur-Pollack, Shlomo Wagner
The medial nucleus of the amygdala (MeA) plays a pivotal role in a variety of mammalian social behaviors. Specifically, activity of the hypothalamic pro-social neuropeptide oxytocin in the MeA was shown to be crucial for social recognition memory. The MeA is also a hub of neuroendocrine activity and expresses a large number of receptors of neuropeptides and hormones. These include oxytocin receptor, estrogen receptor alpha and corticotropin-releasing factor (CRF) receptor type 2 (CRFR2). In a previous study we found that intracerebroventricular (ICV) oxytocin application to anesthetized rats promotes long-term depression (LTD) of the MeA response to electrical stimulation of its main sensory input, the accessory olfactory bulb (AOB)...
April 11, 2018: Psychoneuroendocrinology
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