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https://www.readbyqxmd.com/read/29352249/guided-cracking-of-electrodes-by-stretching-prism-patterned-membrane-electrode-assemblies-for-high-performance-fuel-cells
#1
Chi-Yeong Ahn, Segeun Jang, Yong-Hun Cho, Jiwoo Choi, Sungjun Kim, Sang Moon Kim, Yung-Eun Sung, Mansoo Choi
Guided cracks were successfully generated in an electrode using the concentrated surface stress of a prism-patterned Nafion membrane. An electrode with guided cracks was formed by stretching the catalyst-coated Nafion membrane. The morphological features of the stretched membrane electrode assembly (MEA) were investigated with respect to variation in the prism pattern dimension (prism pitches of 20 μm and 50 μm) and applied strain (S ≈ 0.5 and 1.0). The behaviour of water on the surface of the cracked electrode was examined using environmental scanning electron microscopy...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348579/structural-basis-of-salm5-induced-ptp%C3%AE-dimerization-for-synaptic-differentiation
#2
Zhaohan Lin, Jianmei Liu, Huandi Ding, Fei Xu, Heli Liu
SALM5, a synaptic adhesion molecule implicated in autism, induces presynaptic differentiation through binding to the LAR family receptor protein tyrosine phosphatases (LAR-RPTPs) that have been highlighted as presynaptic hubs for synapse formation. The mechanisms underlying SALM5/LAR-RPTP interaction remain unsolved. Here we report crystal structures of human SALM5 LRR-Ig alone and in complex with human PTPδ Ig1-3 (MeA-). Distinct from other LAR-RPTP ligands, SALM5 mainly exists as a dimer with LRR domains from two protomers packed in an antiparallel fashion...
January 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29341582/in-plane-channel-structured-catalyst-layer-for-polymer-electrolyte-membrane-fuel-cells
#3
Dong-Hyun Lee, Wonhee Jo, Seongmin Yuk, Jaeho Choi, Sungyu Choi, Gisu Doo, Dong Wook Lee, Hee-Tak Kim
In this study, we present a novel catalyst layer (CL) with in-plane flow channels to enhance the mass transports in polymer electrolyte membrane fuel cells (PEMFCs). The CL with in-plane channels on its surface is fabricated by coating a CL slurry onto a surface-treated substrate with the inverse line pattern and transferring the dried CL from the substrate to a membrane. The membrane electrode assembly (MEA) with the in-plane channel-patterned CL (IC-CL) has superior power performances in high current densities compared with an un-patterned, flat CL (FCL), demonstrating a significant enhancement of the mass transport property by the in-plane channels carved in the CL...
January 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29336311/comparison-of-the-effects-of-p2y12-receptor-antagonists-on-platelet-function-and-clinical-outcomes-in-patients-undergoing-primary-pci-a-substudy-of-the-heat-ppci-trial
#4
Adeel Shahzad, Vikram Khanna, Ian Kemp, Matthew Shaw, Christine Mars, Robert Cooper, Keith Wilson, Nick Curzen, Rod H Stables
AIMS: The HEAT-PPCI trial compared bivalirudin and unfractionated heparin in patients undergoing Primary PCI. We report pre-specified, secondary analyses comparing the effects of P2Y12 inhibiting agents on platelet reactivity and clinical events. METHODS AND RESULTS: All patients received pre-procedural oral anti-platelet therapy. During the early stages of the trial, the P2Y12 inhibitor of choice was prasugrel with some use of clopidogrel. Later, routine therapy switched to ticagrelor...
January 16, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29334887/bi-objective-integer-programming-for-rna-secondary-structure-prediction-with-pseudoknots
#5
Audrey Legendre, Eric Angel, Fariza Tahi
BACKGROUND: RNA structure prediction is an important field in bioinformatics, and numerous methods and tools have been proposed. Pseudoknots are specific motifs of RNA secondary structures that are difficult to predict. Almost all existing methods are based on a single model and return one solution, often missing the real structure. An alternative approach would be to combine different models and return a (small) set of solutions, maximizing its quality and diversity in order to increase the probability that it contains the real structure...
January 15, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29318695/risk-factors-for-medication-errors-at-admission-in-preoperatively-screened-patients
#6
Marieke M Ebbens, Kim B Gombert-Handoko, Muhammad Al-Dulaimy, Patricia M L A van den Bemt, Elsbeth J Wesselink
BACKGROUND: Preoperative screening (POS) may help to reduce medication errors at admission (MEA). However, due to the time window between POS and hospital admission, unintentional medication discrepancies may still occur and thus a second medication reconciliation at hospital admission can be necessary. Insight into potential risk factors associated with these discrepancies would be helpful to focus the second medication reconciliation on high-risk patients. OBJECTIVE: To determine the proportion of POS patients with MEA and to identify risk factors for MEA...
January 10, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29316464/comparison-of-tolerance-and-biosorption-of-three-trace-metals-cd-cu-pb-by-the-soil-fungus-absidia-cylindrospora
#7
Quentin Albert, Lydia Leleyter, Mélanie Lemoine, Natacha Heutte, Jean-Philippe Rioult, Lucile Sage, Fabienne Baraud, David Garon
Trace metals cause deterioration of the soil and constitute a major concern for the environment and human health. Bioremediation could be an effective solution for the rectification of contaminated soils. Fungi could play an important role in biodegradation because of the morphology of their mycelium (highly reactive and extensive biological surface) and its physiology (high tolerance to many stresses, production of enzymes and secondary metabolites). Fungi can effectively biosequestrate, or biotransform many organic and inorganic contaminants into a non-bioavailable form...
December 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/29310591/uncontrolled-donation-after-circulatory-death-comparison-of-two-kidney-preservation-protocols-on-graft-outcomes
#8
Claire Delsuc, Alexandre Faure, Julien Berthiller, Didier Dorez, Xavier Matillon, Vannary Meas-Yedid, Bernard Floccard, Guillaume Marcotte, Vanessa Labeye, Maud Rabeyrin, Ricardo Codas, Cécile Chauvet, Philip Robinson, Emmanuel Morelon, Lionel Badet, William Hanf, Thomas Rimmelé
BACKGROUND: Kidney transplantation following uncontrolled donation after circulatory death (uDCD) presents a high risk of delayed graft function due to prolonged warm ischemia time. In order to minimise the effects of ischemia/reperfusion injury during warm ischemia, normothermic recirculation recently replaced in situ perfusion prior to implantation in several institutions. The aim of this study was to compare these preservation methods on kidney graft outcomes. METHODS: The primary endpoint was the one-year measured graft filtration rate (mGFR)...
January 8, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29299587/soft-pillared-magadiite-influence-of-the-interlayer-space-and-amine-type-on-co2-adsorption
#9
Rômulo B Vieira, Heloise O Pastore
Layered silicates are versatile materials that can be grafted with different organosilanes for several applications. Despite this, there are few studies on the use of layered silicate-based materials in CO2 adsorption. In this regard, the present study describes the synthesis of organo-magadiite followed by simultaneous grafting with two organosilanes ((3-glycidyloxypropyl)trimethoxysilane (GPTS) and N1-(3-trimethoxysilylpropyl)diethylenetriamine (TMSPETA)) to prepare an adsorbent labeled Soft-Pillared@Magadiite...
January 4, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29298039/isatin-detection-using-a-boron-doped-diamond-3-in-1-sensing-platform
#10
Mary Ensch, Vanessa Y Maldonado, Greg M Swain, Robert Rechenberg, Michael F Becker, Thomas Schuelke, Cory A Rusinek
Boron-doped diamond (BDD) is a promising electrochemical tool that exhibits excellent chemical sensitivity and stability. These intrinsic advantages coupled with the material's vast microfabrication flexibility make BDD an attractive sensing device. In this study, two different 3-in-1 BDD electrode sensors were fabricated, characterized, and investigated for their capability to detect isatin, an anxiogenic indole that possesses anticonvulsant activity. Each device is comprised of a working, reference, and auxiliary electrode, all made of BDD...
January 3, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29291117/surface-modification-of-poly-vinylidene-fluoride-hollow-fibre-membranes-for-biogas-purification-in-a-gas-liquid-membrane-contactor-system
#11
Pengrui Jin, Chuan Huang, Jiaxiang Li, Yadong Shen, Liao Wang
The wetting of hollow fibre membranes decreases the performance of the liquid-gas membrane contactor for CO2 capture in biogas upgrading. To solve this problem, in this work, a poly(vinylidene fluoride) (PVDF) hollow fibre membrane for a liquid-gas membrane contactor was coated with a superhydrophobic layer composed of a combination of hydrophobic SiO2 nanoparticles and polydimethylsiloxane (PDMS) by the method of spray deposition. A rough layer of SiO2 deposited on the PVDF membrane resulted in an enhanced surface hydrophobicity...
November 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29283402/real-time-monitoring-and-analysis-of-zebrafish-electrocardiogram-with-anomaly-detection
#12
Michael Lenning, Joseph Fortunato, Tai Le, Isaac Clark, Ang Sherpa, Soyeon Yi, Peter Hofsteen, Geethapriya Thamilarasu, Jingchun Yang, Xiaolei Xu, Huy-Dung Han, Tzung K Hsiai, Hung Cao
Heart disease is the leading cause of mortality in the U.S. with approximately 610,000 people dying every year. Effective therapies for many cardiac diseases are lacking, largely due to an incomplete understanding of their genetic basis and underlying molecular mechanisms. Zebrafish (Danio rerio) are an excellent model system for studying heart disease as they enable a forward genetic approach to tackle this unmet medical need. In recent years, our team has been employing electrocardiogram (ECG) as an efficient tool to study the zebrafish heart along with conventional approaches, such as immunohistochemistry, DNA and protein analyses...
December 28, 2017: Sensors
https://www.readbyqxmd.com/read/29280976/a-novel-multi-approach-protocol-for-the-characterization-of-occupational-exposure-to-organic-dust-swine-production-case-study
#13
Carla Viegas, Tiago Faria, Ana Monteiro, Liliana Aranha Caetano, Elisabete Carolino, Anita Quintal Gomes, Susana Viegas
Swine production has been associated with health risks and workers' symptoms. In Portugal, as in other countries, large-scale swine production involves several activities in the swine environment that require direct intervention, increasing workers' exposure to organic dust. This study describes an updated protocol for the assessment of occupational exposure to organic dust, to unveil an accurate scenario regarding occupational and environmental risks for workers' health. The particle size distribution was characterized regarding mass concentration in five different size ranges (PM0...
December 27, 2017: Toxics
https://www.readbyqxmd.com/read/29277174/characteristics-of-managed-entry-agreements-in-australia
#14
Maxine F Robinson, Cathrine Mihalopoulos, Tracy Merlin, Elizabeth Roughead
OBJECTIVES: Australia relies on managed entry agreements (MEAs) for many medicines added to the national Pharmaceutical Benefits Scheme (PBS). Previous studies of Australian MEAs examined public domain documents and were not able to provide a comprehensive assessment of the types and operation of MEAs. This study used government documents approved for release to examine the implementation and administration of MEAs implemented January 2012 to May 2016. METHODS: We accessed documents for medicines with MEAs on the PBS between January 2012 and May 2016...
December 26, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29276833/on-chip-stochastic-detection-of-silver-nanoparticles-without-a-reference-electrode
#15
Pedro G Figueiredo, Leroy Grob, Philipp Rinklin, Kay J Krause, Bernhard Wolfrum
We report the electrochemical detection of 20 nm silver nanoparticles at a chip-based microelectrode array (MEA) without the need for a conventional reference electrode. This is possible due to the system's open-circuit potential allowing the oxidation of silver nanoparticles in the presence of phosphate-buffered saline (PBS). The hypothesis is confirmed by modulating the open-circuit potential via addition of ascorbic acid in solution, effectively inhibiting the detection of silver nanoparticle events. Employing the reference-free detection concept, we observe a linear relationship between the nanoparticle impact frequency at the microelectrodes and the nanoparticle concentration...
December 25, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29274391/electrophysiological-characteristics-and-pharmacological-sensitivity-of-two-lines-of-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-coming-from-two-different-suppliers
#16
Sonia Goineau, Vincent Castagné
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are increasingly used as preclinical tool for predicting drug-induced QT prolongation and arrhythmias. This study was conducted to assess the electrophysiological characteristics and the pharmacological sensitivity of two commercialized hiPSC-CMs. The baseline electrophysiological characteristics measured with a multi-electrode array (MEA) technology differ between Cor.4U and iCell2: higher beat rate (+32bpm) and shorter field potential duration (FPD, -201ms) for Cor...
December 20, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29258317/twenty-four-micrometer-pitch-microelectrode-array-with-6912-channel-readout-at-12-khz-via-highly-scalable-implementation-for-high-spatial-resolution-mapping-of-action-potentials
#17
Jun Ogi, Yuri Kato, Yoshihisa Matoba, Chigusa Yamane, Kazunori Nagahata, Yusaku Nakashima, Takuya Kishimoto, Shigeki Hashimoto, Koichi Maari, Yusuke Oike, Takayuki Ezaki
A 24-μm-pitch microelectrode array (MEA) with 6912 readout channels at 12 kHz and 23.2-μVrms random noise is presented. The aim is to reduce noise in a "highly scalable" MEA with a complementary metal-oxide-semiconductor integration circuit (CMOS-MEA), in which a large number of readout channels and a high electrode density can be expected. Despite the small dimension and the simplicity of the in-pixel circuit for the high electrode-density and the relatively large number of readout channels of the prototype CMOS-MEA chip developed in this work, the noise within the chip is successfully reduced to less than half that reported in a previous work, for a device with similar in-pixel circuit simplicity and a large number of readout channels...
December 19, 2017: Biointerphases
https://www.readbyqxmd.com/read/29250595/comparison-of-nmda-and-ampa-channel-expression-and-function-between-embryonic-and-adult-neurons-utilizing-microelectrode-array-systems
#18
Darin Edwards, Frank Sommerhage, Bonnie Berry, Hanna Nummer, Martina Raquet, Brad Clymer, Maria Stancescu, James J Hickman
Microelectrode arrays (MEAs) are innovative tools used to perform electrophysiological experiments for the study of electrical activity and connectivity in populations of neurons from dissociated cultures. Reliance upon neurons derived from embryonic tissue is a common limitation of neuronal/MEA hybrid systems and perhaps of neuroscience research in general, and the use of adult neurons could model fully functional in vivo parameters more closely. Spontaneous network activity was concurrently recorded from both embryonic and adult rat neurons cultured on MEAs for up to 10 weeks in vitro to characterize the synaptic connections between cell types...
December 11, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29248436/estrogen-signaling-in-the-medial-amygdala-decreases-emotional-stress-responses-and-obesity-in-ovariectomized-rats
#19
Christina M Estrada, Valentina Ghisays, Elizabeth T Nguyen, Jody L Caldwell, Joshua Streicher, Matia B Solomon
Declining estradiol (E2), as occurs during menopause, increases risk for obesity and psychopathology (i.e., depression, anxiety). E2 modulates mood and energy homeostasis via binding to estrogen receptors (ER) in the brain. The often comorbid and bidirectional relationship between mood and metabolic disorders suggests shared hormonal and/or brain networks. The medial amygdala (MeA) is abundant in ERs and regulates mood, endocrine, and metabolic stress responses; therefore we tested the hypothesis that E2 in the MeA mitigates emotional and metabolic dysfunction in a rodent model of surgical menopause...
December 14, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29238653/formation-of-yttria-stabilized-zirconia-nanotubes-by-atomic-layer-deposition-toward-efficient-solid-electrolytes
#20
Eunsoo Kim, Hyunchul Kim, Changdeuck Bae, Daehee Lee, Jooho Moon, Joosun Kim, Hyunjung Shin
We describe a fabrication strategy for preparing yttria-stabilized zirconia nanotube (YSZ-NT) arrays embedded in porous alumina membranes by means of template-directed atomic layer deposition (ALD) technique. The individual YSZ-NTs have a high aspect-ratio of well over 120, about ~ 110 nm in diameter, and ~ 14 µm in length. Interfacing the tube arrays with porous Pt was also introduced on the basis of partial etching technique in order to construct Pt/YSZ-NTs/Pt membrane electrode assembly (MEA) structures...
2017: Nano Convergence
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