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https://www.readbyqxmd.com/read/28651044/the-atmospheric-fate-of-monoethanolamine-enhancing-new-particle-formation-of-sulfuric-acid-as-an-important-removal-process
#1
Hong-Bin Xie, Jonas Elm, Roope Halonen, Nanna Myllys, Theo Kurtén, Markku Kulmala, Hanna Vehkamaki
Monoethanolamine (MEA), a potential atmospheric pollutant from capture unit of a leading CO2 capture technology, could be removed by participating H2SO4-based new particle formation (NPF) as simple amines. Here we evaluated the enhancing potential of MEA on H2SO4-based NPF by examining the formation of molecular clusters of MEA and H2SO4 using a combined quantum chemistry calculations and kinetics modeling. The results indicate that MEA at ppt-level can enhance H2SO4-based NPF. The enhancing potential of MEA is < dimethylamine (DMA), one of the strongest enhancing agents, and ≫ methylamine (MA), in contrast to the order suggested solely by their basicity (MEA < MA < DMA)...
June 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28647606/role-of-streptomyces-pactum-in-phytoremediation-of-trace-elements-by-brassica-juncea-in-mine-polluted-soils
#2
Amjad Ali, Di Guo, Amanullah Mahar, Zhen Wang, Dost Muhammad, Ronghua Li, Ping Wang, Feng Shen, Quanhong Xue, Zengqiang Zhang
The industrial expansion, smelting, mining and agricultural practices have increased the release of toxic trace elements (TEs) in the environment and threaten living organisms. The microbe-assisted phytoremediation is environmentally safe and provide an effective approach to remediate TEs contaminated soils. A pot experiment was conducted to test the potential of an Actinomycete, subspecies Streptomyces pactum (Act12) along with medical stone compost (MSC) by growing Brassica juncea in smelter and mines polluted soils of Feng County (FC) and Tongguan (TG, China), respectively...
June 22, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28638888/modulation-of-key-biochemical-markers-relevant-to-stroke-by-antiaris-africana-leaf-extract-following-cerebral-ischemia-reperfusion-injury
#3
Omotayo B Ilesanmi, Afolabi C Akinmoladun, Olanrewaju Sam Olayeriju, Ibrahim Olabayode Saliu, M Tolulope Olaleye, Afolabi A Akindahunsi
BACKGROUND: Oxidative stress plays a significant role in stroke pathogenesis. Hence, plants rich in antioxidant phytochemicals have been suggested as effective remedies for prevention and treatment of stroke and other neurological diseases. Antiaris africana Engl. (Moraceae) is traditionally used for the management of brain-related problems but there is paucity of data on its anti-stroke potential. MATERIALS AND METHODS: Ischemia/reperfusion injury was induced by a 30 min bilateral common carotid artery occlusion/ 2 h reperfusion (BCCAO/R) in the brain of male Wistar rats...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28634147/csahi-study-2-validation-of-multi-electrode-array-systems-mea60-2100-for-prediction-of-drug-induced-proarrhythmia-using-human-ips-cell-derived-cardiomyocytes-assessment-of-reference-compounds-and-comparison-with-non-clinical-studies-and-clinical-information
#4
Yumiko Nozaki, Yayoi Honda, Hitoshi Watanabe, Shota Saiki, Kiyotaka Koyabu, Tetsuji Itoh, Chiho Nagasawa, Chiaki Nakamori, Chiaki Nakayama, Hiroshi Iwasaki, Shinobu Suzuki, Kohji Tanaka, Etsushi Takahashi, Kaori Miyamoto, Kaoru Morimura, Atsuhiro Yamanishi, Hiroko Endo, Junko Shinozaki, Hisashi Nogawa, Tadahiro Shinozawa, Fumiyo Saito, Takeshi Kunimatsu
With the aim of reconsidering ICH S7B and E14 guidelines, a new in vitro assay system has been subjected to worldwide validation to establish a better prediction platform for potential drug-induced QT prolongation and the consequent TdP in clinical practice. In Japan, CSAHi HEART team has been working on hiPS-CMs in the MEA (hiPS-CMs/MEA) under a standardized protocol and found no inter-facility or lot-to-lot variability for proarrhythmic risk assessment of 7 reference compounds. In this study, we evaluated the responses of hiPS-CMs/MEA to another 31 reference compounds associated with cardiac toxicities, and gene expression to further clarify the electrophysiological characteristics over the course of culture period...
June 17, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28628141/-associations-of-sedentary-behavior-and-physical-activity-with-dyslipidemia
#5
J Zhou, Q Zhou, D P Wang, T Zhang, H J Wang, Y Song, H Z He, M Wang, P Y Wang, A P Liu
OBJECTIVE: To analyze associations of sedentary behavior and physical activity with dyslipidemia among residents in Wuhai city. METHODS: Data about social demographic characteristics, life style, health status and other covariate required for analysis in this study was obtained from a cross-sectional study on a total of 11 497 18-79 years old residents in Wuhai City by questionnaire, body mea-surement and laboratory examination. In this study, sedentary behavior and physical activity were evaluated using international physical activity questionnaire long version (IPAQ)...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28628140/-correlation-study-between-respiratory-death-and-airborne-particles-in-beijing-spatiotemporal-analysis-based-on-satellite-remote-sensing-data
#6
X Y Wu, G X Li, X Y Wang, F C Liang, X C Pan
OBJECTIVE: To use vertical and humidity correcting method to calibrate aerosol optical depth (AOD), and to explore the feasibility of calibrated-AOD as exposure index to measure the level of air pollutants from the ground and to establish the exposure-response relationship between calibrated-AOD and people's health outcomes. METHODS: First of all, we interpolated AOD, PM2.5, relative humidity and planetary boundary layer height using Kriging method to obtain data at different locations and matched different data with respiratory death in Beijing by geographical coordinates...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28627139/direct-electro-oxidation-of-dimethyl-ether-on-pt-cu-nanochains
#7
Bar Gavriel, Ronit Sharabi, Lior Elbaz
In this work, new catalyst for the direct electro-oxidation of dimethyl ether (DME) was synthesized and studied using an array of techniques. One of the most prominent catalysts for this reaction, platinum copper alloy (PtCu), was synthesized in an easy and low cost approach. Structural characterizations such as X-ray diffraction (XRD), scanning electron microscopy (SEM), high resolution transmission electron microscopy (HR-TEM) and elemental analysis revealed that the synthesized PtCu nanoparticles (3 nm on average), formed homogeneous NanoChains without aggregation of metallic platinum or copper...
June 18, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28623091/dna-repair-and-systemic-lupus-erythematosus
#8
REVIEW
Rithy Meas, Matthew J Burak, Joann B Sweasy
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with no known cure that affects at least five million people worldwide. Monozygotic twin concordance and familial aggregation studies strongly suggest that lupus results from genetic predisposition along with environmental exposures including UV light. The majority of the common risk alleles associated with genetic predisposition to SLE map to genes associated with the immune system. However, evidence is emerging that implicates a role for aberrant DNA repair in the development of lupus...
June 9, 2017: DNA Repair
https://www.readbyqxmd.com/read/28621488/effects-of-intradialytic-neuromuscular-electrical-stimulation-on-strength-and-muscle-architecture-in-patients-with-chronic-kidney-failure-randomized-clinical-trial
#9
Jociane Schardong, Thiago Dipp, Camila Bassani Bozzeto, Marília Godoy da Silva, Gabriela Leivas Baldissera, Raíssa de Castro Ribeiro, Bruna Pan Valdemarca, Alexandre Severo do Pinho, Graciele Sbruzzi, Rodrigo Della Méa Plentz
This study aimed to evaluate the effects of neuromuscular electrical stimulation (NMES) on muscle strength and architecture, functional capacity, and endothelial function in patients with chronic kidney failure (CKF) on hemodialysis (HD). Twenty-one patients with CKF on HD were randomized into a control group (CG; n = 10) and neuromuscular electrical stimulation group (NMESG; n = 11) who received NMES in the quadriceps muscle for 8 weeks, 3 times/week (20-34 min) during HD sessions. The muscle strength of the lower limbs was evaluated by dynamometry and sit-and-stand test (SST); muscle architecture through ultrasonography; functional capacity by the distance covered in a 6-min walk test and the endothelial function by flow-mediated dilatation technique of the brachial artery...
June 16, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28620952/operando-3d-visualization-of-migration-and-degradation-of-pt-cathode-catalyst-in-a-polymer-electrolyte-fuel-cell
#10
Hirosuke Matsui, Nozomu Ishiguro, Tomoya Uruga, Oki Sekizawa, Kotaro Higashi, Naoyuki Maejima, Mizuki Tada
The three-dimensional (3D) distribution and oxidation state of a Pt cathode catalyst in a practical membrane electrode assembly (MEA) were visualized in a practical polymer electrolyte fuel cell (PEFC) under fuel-cell operating conditions. Operando 3D computed-tomography imaging with X-ray absorption near edge structure (XANES) spectroscopy (CT-XANES) clearly revealed the heterogeneous migration and degradation of Pt cathode catalyst in an MEA during accelerated degradation test (ADT) of PEFC. The degradative Pt migration proceeded over the entire cathode catalyst layer and spread to MEA depth direction into the Nafion membrane...
June 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28620291/network-wide-adaptive-burst-detection-depicts-neuronal-activity-with-improved-accuracy
#11
Inkeri A Välkki, Kerstin Lenk, Jarno E Mikkonen, Fikret E Kapucu, Jari A K Hyttinen
Neuronal networks are often characterized by their spiking and bursting statistics. Previously, we introduced an adaptive burst analysis method which enhances the analysis power for neuronal networks with highly varying firing dynamics. The adaptation is based on single channels analyzing each element of a network separately. Such kind of analysis was adequate for the assessment of local behavior, where the analysis focuses on the neuronal activity in the vicinity of a single electrode. However, the assessment of the whole network may be hampered, if parts of the network are analyzed using different rules...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28616031/polyethylene-glycol-restores-axonal-conduction-after-corpus-callosum-transection
#12
Ravinder Bamba, D Colton Riley, Richard B Boyer, Alonda C Pollins, R Bruce Shack, Wesley P Thayer
Polyethylene glycol (PEG) has been shown to restore axonal continuity after peripheral nerve transection in animal models. We hypothesized that PEG can also restore axonal continuity in the central nervous system. In this current experiment, coronal sectioning of the brains of Sprague-Dawley rats was performed after animal sacrifice. 3Brain high-resolution microelectrode arrays (MEA) were used to measure mean firing rate (MFR) and peak amplitude across the corpus callosum of the ex-vivo brain slices. The corpus callosum was subsequently transected and repeated measurements were performed...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28611057/middle-ear-adenoma-with-uncommon-presentation-and-literature-review
#13
Lin Wang, Nengtai Ouyang, Hai Xia Guo, Qing-Yu Liu
Middle ear adenoma (MEA) is a rare benign tumour. Here we report a case of MEA in a 39-year-old man with hearing loss. Some significant histopathological features of MEA and neuroendocrine differentiation identified by immunohistochemistry are described. The tumour showed remarkable and rare degenerative histological characteristics. There were a few tumour cells which were covered by degenerated tissue. Consequently, following frozen biopsy, the tumour was misdiagnosed as chronic ear inflammation. No recurrence was seen in this patient after 45 months of follow-up; regular clinical and radiological follow-up is necessary since recurrence is possible...
June 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28608907/organs-on-chips-with-combined-multi-electrode-array-and-transepithelial-electrical-resistance-measurement-capabilities
#14
Ben M Maoz, Anna Herland, Olivier Y F Henry, William D Leineweber, Moran Yadid, John Doyle, Robert Mannix, Ville J Kujala, Edward A FitzGerald, Kevin Kit Parker, Donald E Ingber
Here we demonstrate that microfluidic cell culture devices, known as Organs-on-a-Chips can be fabricated with multifunctional, real-time, sensing capabilities by integrating both multi-electrode arrays (MEAs) and electrodes for transepithelial electrical resistance (TEER) measurements into the chips during their fabrication. To prove proof-of-concept, simultaneous measurements of cellular electrical activity and tissue barrier function were carried out in a dual channel, endothelialized, heart-on-a-chip device containing human cardiomyocytes and a channel-separating porous membrane covered with a primary human endothelial cell monolayer...
June 13, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28605385/time-dependent-increase-in-the-network-response-to-the-stimulation-of-neuronal-cell-cultures-on-micro-electrode-arrays
#15
Monica L Gertz, Zachary Baker, Sharon Jose, Nathalia Peixoto
Micro-electrode arrays (MEAs) can be used to investigate drug toxicity, design paradigms for next-generation personalized medicine, and study network dynamics in neuronal cultures. In contrast with more traditional methods, such as patch-clamping, which can only record activity from a single cell, MEAs can record simultaneously from multiple sites in a network, without requiring the arduous task of placing each electrode individually. Moreover, numerous control and stimulation configurations can be easily applied within the same experimental setup, allowing for a broad range of dynamics to be explored...
May 29, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28595427/challenging-equipotency-calculation-for-hydromorphone-after-long-term-intravenous-application
#16
Benjamin Luchting, Banafscheh Rachinger-Adam, Nikolai Hulde, Jens Heyn, Shahnaz Christina Azad
In advanced stages, most cancer patients suffer from pain which can usually be well controlled following the World Health Organization (WHO) level scheme. While the majority of patients report adequate pain relief by strong opioids (WHO III), some require an opioid rotation. Despite the existence of conversion tables, these rotations mea lead to inadequate pain control or life threatening events. Here, we report about a patient with urothelial cell carcinoma presenting in our Department of Pain Medicine with massive pain aggravation up to NRS values of 10/10 despite administration of the highest dose of intravenously applied hydromorphone...
March 16, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28587814/motion-energy-analysis-reveals-altered-body-movement-in-youth-at-risk-for-psychosis
#17
Derek J Dean, Alayna T Samson, Raeana Newberry, Vijay A Mittal
BACKGROUND: Growing evidence suggests that movement abnormalities occur prior to the onset of psychosis. Innovations in technology and software provide the opportunity for a fine-tuned and sensitive measurement of observable behavior that may be particularly useful to detecting the subtle movement aberrations present during the prodromal period. METHODS: In the present study, 54 youth at ultrahigh risk (UHR) for psychosis and 62 healthy controls participated in structured clinical interviews to assess for an UHR syndrome...
June 3, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28578402/using-bamboo-biochar-with-compost-for-the-stabilization-and-phytotoxicity-reduction-of-heavy-metals-in-mine-contaminated-soils-of-china
#18
Amjad Ali, Di Guo, Yue Zhang, Xining Sun, Shuncheng Jiang, Zhanyu Guo, Hui Huang, Wen Liang, Ronghua Li, Zengqiang Zhang
Anthropogenic activities have transformed the global geochemical cycling of heavy metals (HMs). Many physical, chemical and biological methods are used to reduce the toxicity of HMs to humans, plants and environment. This study aimed to investigate the immobilization and phytotoxicity reduction of HMs after application of bamboo biochar (BB) in mine-polluted soil in Feng county (FC) and Tongguan (TG). The results showed that BB application to contaminated soil immobilized HMs (Zn, Pb, Cd and Cu). The soil pH and EC increased and the bioavailability of HMs decreased in FC and TG, whereas Pb and Cu increased in TG soil...
June 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28575455/adolescent-alcohol-exposure-induced-changes-in-alpha-melanocyte-stimulating-hormone-and-neuropeptide-y-pathways-via-histone-acetylation-in-the-brain-during-adulthood
#19
Dadasaheb M Kokare, Evan J Kyzar, Huaibo Zhang, Amul J Sakharkar, Subhash C Pandey
Background: Adolescent intermittent ethanol (AIE) exposure causes long-lasting alterations in brain epigenetic mechanisms. Melanocortin and neuropeptide Y (NPY) signaling interact and are affected by ethanol exposure in the brain. Here, the persistent effects of AIE on alpha-melanocyte stimulating hormone (α-MSH), melanocortin 4 receptor (MC4R) and NPY expression and their regulation by histone acetylation mechanisms were investigated in adulthood. Methods: Male rats were exposed to AIE (2 g/kg, i...
May 31, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28573253/in-vivo-carbon-tetrachloride-induced-hepatoprotective-and-in-vitro-cytotoxic-activities-of-garcinia-hombroniana-seashore-mangosteen
#20
Nargis Jamila, Naeem Khan, Amir Atlas Khan, Imran Khan, Sadiq Noor Khan, Zainal Amiruddin Zakaria, Melati Khairuddean, Hasnah Osman, Kyong Su Kim
BACKGROUND: Garcinia hombroniana, known as "manggis hutan" (jungle mangosteen) in Malaysia, is distributed in tropical Asia, Borneo, Thailand, Andaman, Nicobar Islands, Vietnam and India. In Malaysia, its ripened crimson sour fruit rind is used as a seasoning agent in curries and culinary dishes. Its roots and leaves decoction is used against skin infections and after child birth. This study aimed to evaluate in vivo hepatoprotective and in vitro cytotoxic activities of 20% methanolic ethyl acetate (MEA) G...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
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