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https://www.readbyqxmd.com/read/28495443/dose-volume-correlation-of-cumulative-vaginal-doses-and-late-toxicity-after-adjuvant-external-radiation-and-brachytherapy-for-cervical-cancer
#1
Roshni Singh, Supriya Chopra, Reena Engineer, Siji Paul, Sadhana Kannan, Sarthak Mohanty, Jamema Swamidas, Umesh Mahantshetty, Jaya Ghosh, Amita Maheshwari, T Surappa Shylasree, Rajendra Kerkar, Sudeep Gupta, Shyam Shrivastava
PURPOSE: To investigate dose-response relationship between vaginal doses and long-term morbidity. METHODS AND MATERIALS: Patients receiving adjuvant pelvic (chemo) radiation and brachytherapy for cervical cancer from January 2011 to December 2014 were included. Baseline vaginal length was determined clinically and from imaging at BT planning. Dose points were defined along mucosa and at 5 mm depth at 12, 3, 6, and 9 'o' clock positions at every 2 cm from apex to introitus...
May 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28460202/neoplastic-sigmoid-uterine-fistula-an-exceptional-complication-of-large-intestine-cancer
#2
G Zanghì, V Leanza, R Vecchio, A D'Agati, S Cordova, N M Rinzivillo, M Lodato, G Leanza
Neoplastic sigmoid-uterine fistula is an extremely rare condition because the uterus is a thick and muscular organ. A 74-year-old woman was admitted to the First Aid Station suffering from abdominal pain and foul smelling vaginal discharge. Gynaecological examination showed fecal drainage from the cervical orifice, while the uterus was regular in size but very firm and painful. Ovaries and fallopian tubes were not palpable owing to abdominal tenderness. Ultrasounds reveled inhomogeneous thickening of uterine cavity, without detecting fistula...
January 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28258616/focal-salvage-high-intensity-focused-ultrasound-in-radiorecurrent-prostate-cancer
#3
Abi Kanthabalan, Max Peters, Marco Van Vulpen, Neil McCartan, Richard Graham Hindley, Amr Emara, Caroline M Moore, Manit Arya, Mark Emberton, Hashim Uddin Ahmed
OBJECTIVE: To assess short- to medium-term cancer control rates and side effects of focal salvage high- intensity focused ultrasound (HIFU). MATERIALS AND METHODS: A retrospective registry analysis identified 150 men who underwent focal salvage HIFU (FS-HIFU) (Sonablate 500) between November 2006 and August 2015. Metastatic disease was excluded by nodal assessment on the pelvic MRI, a radioisotope bone scan and positron-emission tomography (PET) imaging (choline-18F-fluorodeoxyglucose PET or choline PET-CT)...
March 4, 2017: BJU International
https://www.readbyqxmd.com/read/28035252/signet-ring-colorectal-carcinoma-do-we-need-to-improve-the-treatment-algorithm
#4
Anup Sunil Tamhankar, Parag Ingle, Reena Engineer, Munita Bal, Vikas Ostwal, Avanish Saklani
AIM: To elaborate about this peculiar variant from a tertiary cancer center from India. METHODS: It's a retrospective study (2011-2014) of all patients diagnosed with signet ring colo-rectal cancer (SRCC). Various clinico-pathological variables were studied. RESULTS: One hundred and seventy consecutive patients with SRCC were diagnosed (11.4% of all colorectal cancers). Median Age of the cohort was 41 years. Most common location was recto-sigmoid area (54...
December 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28009150/high-intensity-focused-ultrasound-as-first-line-salvage-therapy-in-prostate-cancer-local-relapse-after-radical-prostatectomy-4-year-follow-up-outcomes
#5
Giuseppe Palermo, Angelo Totaro, Emilio Sacco, Nazario Foschi, Gaetano Gulino, Marco Racioppi, Pierfrancesco Bassi, Francesco Pinto
BACKGROUND: Prostate cancer (PCa) is the most commonly diagnosed malignancy in men and the second leading cause of cancer death in developed countries. Despite the primary treatments, 20-30% of patients experience a recurrence. The main objective of this study was to evaluate the clinical efficacy of salvage high intensity focused ultrasound (HIF U) after radical prostatectomy in terms of biochemical free survival rate (BFSR) and PSA nadir. METHODS: Twenty two patients with local recurrence of Pca after radical prostatectomy underwent HIFU as first-line salvage therapy...
February 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27995001/evaluation-of-the-patients-with-colorectal-cancer-undergoing-emergent-curative-surgery
#6
Fikri Kundes, Metin Kement, Kenan Cetin, Levent Kaptanoglu, Aytaç Kocaoglu, Mehmet Karahan, Serkan Fatih Yegen, Ali Emre Atici, Osman Civil, Mehmet Eser, Tebessum Cakir, Nejdet Bildik
BACKGROUND: The aim of our study is to evaluate perioperative and mid-term oncologic outcomes of the patients with colorectal cancer, who underwent emergent curative surgery. METHODS: The study included all patients with colorectal cancer, who underwent surgery for curative intent between 1 January 2012 and 31 December 2014 in General Surgery Department of Kartal Training and Research Hospital. The patients were divided into two groups according to the type of admission (emergent or elective)...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27895681/rectal-separation-using-hydroxypropyl-methylcellulose-in-intracavitary-brachytherapy-of-cervical-cancer-an-innovative-approach
#7
Swapnendu Basu, Kazi Sazzad Manir, Abhishek Basu, Koushik Ghosh
PURPOSE: This study was initiated to prove feasibility of hydrogel application in recto-vaginal space in intracavitary brachytherapy (ICBT) of cervical cancer in order to reduce rectal toxicity. MATERIAL AND METHODS: In a case of stage IIB cervical cancer, after external beam radiotherapy (EBRT), we planned ICBT 7 Gy × 3 fractions. In 1(st) fraction (Plan 1), due to narrow separation between rectum and cervix (0.18 cm), only 5 Gy was delivered at point A (with high-risk clinical target volume [HR-CTV] D90 5...
October 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27895678/prostate-brachytherapy-in-ghana-our-initial-experience
#8
James Edward Mensah, Joel Yarney, Verna Vanderpuye, Evans Akpakli, Samuel Tagoe, Evans Sasu
PURPOSE: This study presents the experience of a brachytherapy team in Ghana with a focus on technology transfer and outcome. The team was initially proctored by experienced physicians from Europe and South Africa. MATERIAL AND METHODS: A total of 90 consecutive patients underwent either brachytherapy alone or brachytherapy in combination with external beam radiotherapy for prostate carcinoma between July 2008 and February 2014 at Korle Bu Teaching Hospital, Accra, Ghana...
October 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27681490/hifu-as-first-line-salvage-therapy-in-prostate-cancer-local-relapse-after-radical-prostatectomy-4-year-follow-up-outcomes
#9
Giuseppe Palermo, Angelo Totaro, Emilio Sacco, Nazario Foschi, Gaetano Gulino, Marco Racioppi, Pierfrancesco Bassi, Francesco Pinto
BACKGROUND: Prostate cancer (PCa) is the most commonly diagnosed malignancy in men and the second leading cause of cancer death in developed countries. Despite the primary treatments, 20-30% of patients experience a recurrence. The main objective of this study was to evaluate the clinical efficacy of salvage HIFU after radical prostatectomy in terms of biochemical free survival rate (BFSR) and PSA nadir. METHODS: Twenty two patients with local recurrence of Pca after radical prostatectomy underwent HIFU as first-line salvage therapy...
September 28, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27538037/methods-of-a-national-colorectal-cancer-cohort-study-the-piper-project
#10
Melissa J Firth, Katrina J Sharples, Victoria A Hinder, Jerome Macapagal, Diana Sarfati, Sarah L Derrett, Andrew G Hill, Charis Brown, Papaarangi Mj Reid, Ross A Lawrenson, Carol Atmore, John P Keating, Mark Jeffery, Adrian H Secker, Charles De Groot, Christopher Gca Jackson, Michael Pn Findlay
AIM: Colorectal cancer is one of the most common cancers, and second-leading cause of cancer-related death, in New Zealand. The PIPER (Presentations, Investigations, Pathways, Evaluation, Rx [treatment]) project was undertaken to compare presentation, investigations, management and outcomes by rurality, ethnicity and deprivation. This paper reports the methods of the project, a comparison of PIPER patient diagnoses to the New Zealand Cancer Registry (NZCR) data, and the characteristics of the PIPER cohort...
August 19, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27472731/emphysematous-epididymo-orchitis-as-a-camouflage-of-prostate-invasion-secondary-to-rectum-cancer-a-case-report
#11
Ching-Heng Yen, Chin-Yu Liu, Tai-Lung Cha, Sheng-Tang Wu, En Meng, Guang-Huan Sun, Dah-Shyong Yu, Hong-I Chen, Sun-Yran Chang, Chih-Wei Tsao
INTRODUCTION: Emphysematous epididymo-orchitis is a rare cause of acute scrotum pain characterized by gas formation within the tissue. Diabetes mellitus and recto-seminal fistula secondary to sigmoid diverticulitis are generally accepted as being responsible for this disease. However, prostate invasion secondary to rectal cancer may be considered to be a newly identified pathogenetic mechanism. Herein, we report this rare case and illustrate the pathogenesis. CASE PRESENTATION: A 69-year-old man arrived at our emergency department presenting with sepsis and acute scrotal pain...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27469289/management-of-radiation-therapy-oncology-group-grade-4-urinary-adverse-events-after-radiotherapy-for-prostate-cancer
#12
Erik N Mayer, Jonathan D Tward, Mitchell Bassett, Sara M Lenherr, James M Hotaling, William O Brant, William T Lowrance, Jeremy B Myers
OBJECTIVE: To describe the management of Radiation Therapy Oncology Group (RTOG) grade 4 urinary adverse events (UAEs) after radiotherapy (RT) for prostate cancer (PCa). METHODS: We conducted a single-centre retrospective review, over a 6-year period (2010-2015), to identify men with RTOG grade 4 UAEs after RT for PCa. RT was classified as combined therapy (radical prostatectomy [RP] followed by external beam radiotherapy [EBRT], EBRT + low-dose-rate [LDR] brachytherapy, EBRT + high-dose-rate [HDR] brachytherapy or other combinations of RT) or monotherapy RT...
May 2017: BJU International
https://www.readbyqxmd.com/read/27416635/focal-cryotherapy-for-localized-prostate-cancer
#13
REVIEW
K J Tay, T J Polascik
OBJECTIVE: To systematically review the oncological and functional outcomes of contemporary primary prostate focal cryotherapy for localized prostate cancer in the context of current developments in prostate focal therapy. METHODS: We performed a systematic search of the Pubmed, Cochrane and Embase databases to identify studies where primary prostate focal cryotherapy was performed to treat prostate cancer. These included reports on focal/ lesion/ sector ablation, hemi-ablation and partial prostate ablation...
July 2016: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/27330909/a-case-of-recto-sigmoid-endometriosis-mimicking-carcinoma
#14
Ritu Rana, Sandeep Sharma, Harjeet Narula, Brijesh Madhok
INTRODUCTION: Although endometriosis with sigmoid serosal involvement is not uncommon in women of childbearing age, the mucosal and lymph node involvement is rare and differential diagnosis from colon cancer and diverticulitis may be difficult due to poor diagnostic accuracy of colonoscopy and colonic biopsies. CASE PRESENTATION: We present a case of a nulliparous woman presenting with large bowel obstruction. She underwent emergency sigmoid colectomy based on clinical and radiological findings...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27267048/vaginal-dose-de-escalation-in-image-guided-adaptive-brachytherapy-for-locally-advanced-cervical-cancer
#15
Sandy Mohamed, Jacob Christian Lindegaard, Astrid A C de Leeuw, Ina Jürgenliemk-Schulz, Kathrin Kirchheiner, Christian Kirisits, Richard Pötter, Kari Tanderup
PURPOSE: Vaginal stenosis is a major problem following radiotherapy in cervical cancer. We investigated a new dose planning strategy for vaginal dose de-escalation (VDD). MATERIALS AND METHODS: Fifty consecutive locally advanced cervical cancer patients without lower or middle vaginal involvement at diagnosis from 3 institutions were analysed. External beam radiotherapy was combined with MRI-guided brachytherapy. VDD was obtained by decreasing dwell times in ovoid/ring and increasing dwell times in tandem/needles...
June 3, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27222282/yield-of-a-second-screening-colonoscopy-10-years-after-an-initial%C3%A2-negative-examination-in-average-risk-individuals
#16
Prasanna L Ponugoti, Douglas K Rex
BACKGROUND AND AIMS: Current guidelines recommend screening colonoscopy at 10-year intervals in average-risk individuals who had baseline screening colonoscopy (no polyps or only hyperplastic polyps ≤5 mm in the recto-sigmoid colon), but the yield of repeat screening at 10 years is unknown. Our aim was to describe the yield of second screening colonoscopy in average-risk individuals performed at least 8 years after a first screening colonoscopy had shown no polyps or only distal hyperplastic polyps ≤5 mm in size...
January 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/26951947/medium-term-outcomes-after-whole-gland-high-intensity-focused-ultrasound-for-the-treatment-of-nonmetastatic-prostate-cancer-from-a-multicentre-registry-cohort
#17
Louise Dickinson, Manit Arya, Naveed Afzal, Paul Cathcart, Susan C Charman, Andrew Cornaby, Richard G Hindley, Henry Lewi, Neil McCartan, Caroline M Moore, Senthil Nathan, Chris Ogden, Raj Persad, Jan van der Meulen, Shraddha Weir, Mark Emberton, Hashim U Ahmed
BACKGROUND: High-intensity focused ultrasound (HIFU) is a minimally-invasive treatment for nonmetastatic prostate cancer. OBJECTIVE: To report medium-term outcomes in men receiving primary whole-gland HIFU from a national multi-centre registry cohort. DESIGN, SETTING, AND PARTICIPANTS: Five-hundred and sixty-nine patients at eight hospitals were entered into an academic registry. INTERVENTION: Whole-gland HIFU (Sonablate 500) for primary nonmetastatic prostate cancer...
October 2016: European Urology
https://www.readbyqxmd.com/read/26805338/-complete-response-to-chemotherapy-after-resection-of-rectal-cancer-with-virchow-s-lymph-node-metastasis
#18
Kenji Kuroda, Bunzo Nakata, Shigetomi Nakao, Tomohiro Lee, Masashige Tendo, Takeshi Hori, Hideaki Yokomatsu, Kosei Hirakawa, Tetsuro Ishikawa
A 62-year-old woman was admitted to our hospital because of bloody stool. Colonoscopy revealed stenosis by a type 2 tumor of the recto-sigmoid colon. A biopsy specimen contained moderately differentiated adenocarcinoma. Thoraco-abdominal computed tomography (CT) showed liver metastasis (S7, 10 mm) and enlargement of Virchow's lymph node (17 mm) and several para-aortic lymph nodes (15 mm on average). Because of oozing from the tumor and severe stenosis of the recto-sigmoid colon, we performed laparoscopic-assisted high anterior resection of the primary lesion...
November 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/26780997/dose-effect-relationship-and-risk-factors-for-vaginal-stenosis-after-definitive-radio-chemo-therapy-with-image-guided-brachytherapy-for-locally-advanced-cervical-cancer-in-the-embrace-study
#19
Kathrin Kirchheiner, Remi A Nout, Jacob C Lindegaard, Christine Haie-Meder, Umesh Mahantshetty, Barbara Segedin, Ina M Jürgenliemk-Schulz, Peter J Hoskin, Bhavana Rai, Wolfgang Dörr, Christian Kirisits, Søren M Bentzen, Richard Pötter, Kari Tanderup
BACKGROUND/PURPOSE: To identify risk factors for vaginal stenosis and to establish a dose-effect relationship for image-guided brachytherapy in locally advanced cervical cancer. MATERIALS/METHODS: Patients from the ongoing EMBRACE study with prospectively assessed morbidity (CTCAEv3.0) at baseline and at least one follow-up were selected. Patient-, disease- and treatment characteristics were tested as risk factors for vaginal stenosis G ⩾ 2 in univariate and multivariable analyses (Cox proportional hazards model) and a dose-effect curve was deduced from the estimates...
January 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/26778712/rectal-ulcers-and-rectoprostatic-fistulas-after-125-i-low-dose-rate-prostate-brachytherapy
#20
Nelson Leong, Howard H Pai, W James Morris, Mira Keyes, Tom Pickles, Scott Tyldesley, Jonn Wu
PURPOSE: Radiation induced rectal ulcers and fistulas are rare but significant complications of low dose rate prostate brachytherapy for localized prostate cancer. We describe the incidence of ulcers and fistulas, and associated risk factors. MATERIALS AND METHODS: We reviewed the records of 4,690 patients with localized prostate cancer who were treated with low dose rate (125)I prostate brachytherapy to a dose of 144 Gy with or without 6 months of androgen deprivation therapy...
June 2016: Journal of Urology
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