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Depression and rejection

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https://www.readbyqxmd.com/read/29678874/mitochondrial-morphological-and-functional-reprogramming-following-cd137-4-1bb-co-stimulation
#1
Alvaro Teijeira, Sara Labiano, Saray Garasa, Inaki Etxeberria, Eva Santamaria, Ana Rouzaut, Michel Enamorado, Arantza Azpilikueta, Susana Inoges, Elixabet Bolanos-Mateo, Maria Angela Aznar, Alfonso R Sanchez-Paulete, David Sancho, Ignacio Melero
T and NK lymphocytes express CD137 (4-1BB), a costimulatory receptor of the TNFR family whose function is exploitable for cancer immunotherapy. Mitochondria regulate the function and survival of T lymphocytes. Herein, we show that CD137 costimulation provided by agonist mAb and CD137L (4-1BBL) induced mitochondria enlargement that resulted in enhanced mitochondrial mass and transmembrane potential in human and mouse CD8+ T cells. Such mitochondrial changes increased T-cell respiratory capacities and were critically dependent on mitochondrial fusion protein OPA-1 expression...
April 20, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29658759/parent-contributions-to-friendship-stability-during-the-primary-school-years
#2
Daniel J Dickson, Melissa Huey, Brett Laursen, Noona Kiuru, Jari-Erik Nurmi
The present study examines whether characteristics of parents predict the stability of a child's best friendships across the primary school years. Participants included 1,523 Finnish children (766 boys) who reported involvement in a total of 1,326 reciprocated friendship dyads in the 1st grade (M = 7.16 years old). At the onset of the study, mothers and fathers completed questionnaires describing their own parenting (i.e., behavioral control, psychological control, and affection toward the child) and depressive symptoms...
March 2018: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/29648989/analysis-of-sexual-problems-in-men-with-psoriasis
#3
Marta Wojciechowska-Zdrojowy, Adam Reich, Jacek C Szepietowski, Adam Wojciechowski
INTRODUCTION: Psoriasis may have negative impact on many aspects of patient life. OBJECTIVE: The aim of the study was to evaluate the influence of psoriasis on erectile dysfunction and other sexual problems in men with psoriasis. MATERIALS AND METHODS: A total of 76 men aged between 20 and 66 years (mean 43.9±13.2 years) were enrolled. Psoriasis severity assessed according to PASI ranged from 2.0 to 49.8 points (mean 15.1±10.3 points). All patients were asked to complete International Index of Erectile Function (IIEF-5), Beck's Depression Inventory and Dermatology Life Quality Index...
April 12, 2018: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/29547816/abnormal-emotional-and-neural-responses-to-romantic-rejection-and-acceptance-in-depressed-women
#4
Ashley A Yttredahl, Erin McRobert, Benjamin Sheler, Brian J Mickey, Tiffany M Love, Scott A Langenecker, Jon-Kar Zubieta, David T Hsu
INTRODUCTION: Responding adaptively to one's social environment is a key factor predicting the course of major depressive disorder (MDD). Socially rejecting events can exacerbate, whereas socially accepting events can ameliorate depressive symptoms. The neural responses to rejection and acceptance in MDD are relatively unexplored. METHODS: We used functional magnetic resonance imaging (fMRI) to measure neural responses to romantic rejection and acceptance in women diagnosed with current MDD (n = 19) and a matched group of healthy controls (HCs) (n = 19)...
July 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29528672/interpersonal-stressors-and-negative-affect-in-individuals-with-borderline-personality-disorder-and-community-adults-in-daily-life-a-replication-and-extension
#5
Johanna Hepp, Sean P Lane, Andrea M Wycoff, Ryan W Carpenter, Timothy J Trull
Affective instability and interpersonal stress are key features of borderline personality disorder (BPD). They were shown to covary in the daily lives of patients in a recent ambulatory assessment study (Hepp et al., 2017) that observed comparatively larger positive associations between interpersonal stressors and negative affect in individuals with BPD than those with depressive disorders. The present study sought to replicate these findings, collecting data on hostility, sadness, fear, and rejection or disagreement events from 56 BPD and 60 community control participants for 21 days, 6 times a day...
February 2018: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29528006/effects-of-web-based-educational-intervention-on-self-management-in-kidney-recipients
#6
Çiğdem Çetin, Fatma Cebeci
Information technology and the Internet are rapidly becoming effective tools for teaching. Selfmanagement skills are important for adaptation and long-term survival in kidney recipients. Web-based training may help patients develop self-management skills through information access. This literature review aimed to determine the effects of Web-based educational intervention on self-management in kidney recipients. The Internet supports effective health education intervention strategies by providing a learning environment that is always available...
March 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29517347/peer-support-workers-experiences-of-supporting-women-with-postnatal-depression-a-constant-comparative-exploration
#7
Ruth Carter, Fiona Cust, Elizabeth Boath
OBJECTIVE: To explore the lived experiences of peer support workers (PSWs) during their intervention with mothers suffering from postnatal depression (PND). BACKGROUND: Postnatal depression is a major public health concern affecting approximately 13% of women worldwide. There is evidence within recent literature that peer support may have a positive effect upon women suffering with PND. METHODS: Written data from the PSW's logbooks, interviews and supervisory sessions was collected and thematically analysed...
December 26, 2017: Journal of Reproductive and Infant Psychology
https://www.readbyqxmd.com/read/29508115/identity-bipolar-disorder-and-the-problem-of-self-narration-in-kay-redfield-jamison-s-an-unquiet-mind-and-ellen-forney-s-marbles
#8
Bethany Ober Mannon
The field of narrative medicine holds that personal narratives about illness have the potential to give illness meaning and to create order out of disparate facets of experience, thereby aiding a patient's treatment and resisting universalizing medical discourse. Two narratives of bipolar disorder, Kay Redfield Jamison's prose memoir An Unquiet Mind (1995) and Ellen Forney's graphic memoir Marbles (2012) challenge these ideas. These writers demonstrate that one result of bipolar disorder is a rupture to their sense of identity, making straightforward and verbal forms of narrative impossible...
March 6, 2018: Journal of Medical Humanities
https://www.readbyqxmd.com/read/29500161/improving-transplant-medication-safety-through-a-pharmacist-empowered-patient-centered-mhealth-based-intervention-transafe-rx-study-protocol
#9
James N Fleming, Frank Treiber, John McGillicuddy, Mulugeta Gebregziabher, David J Taber
BACKGROUND: Medication errors, adverse drug events, and nonadherence are the predominant causes of graft loss in kidney transplant recipients and lead to increased healthcare utilization. Research has demonstrated that clinical pharmacists have the unique education and training to identify these events early and develop strategies to mitigate or prevent downstream sequelae. In addition, studies utilizing mHealth interventions have demonstrated success in improving the control of chronic conditions that lead to kidney transplant deterioration...
March 2, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29497386/psychosocial-variables-associated-with-immunosuppressive-medication-non-adherence-after-renal-transplantation
#10
Jennifer Felicia Scheel, Katharina Schieber, Sandra Reber, Lisa Stoessel, Elisabeth Waldmann, Sabine Jank, Kai-Uwe Eckardt, Franziska Grundmann, Frank Vitinius, Martina de Zwaan, Anna Bertram, Yesim Erim
Introduction: Non-adherence to immunosuppressive medication is regarded as an important factor for graft rejection and loss after successful renal transplantation. Yet, results on prevalence and relationship with psychosocial parameters are heterogeneous. The main aim of this study was to investigate the association of immunosuppressive medication non-adherence and psychosocial factors. Methods: In 330 adult renal transplant recipients (≥12 months posttransplantation), health-related quality of life, depression, anxiety, social support, and subjective medication experiences were assessed, and their associations with patient-reported non-adherence was evaluated...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29485675/postpartum-bonding-difficulties-and-adult-attachment-styles-the-mediating-role-of-postpartum-depression-and-childbirth-related-ptsd
#11
Ilana S Hairston, Jonathan E Handelzalts, Chen Assis, Michal Kovo
Despite decades of research demonstrating the role of adult attachment styles and early mother-infant bonding in parenting behaviors and maternal mental health, these constructs have seldom been studied together. The present study aimed to investigate the relationship between attachment styles and specific bonding difficulties of mothers. In addition, as postpartum depression and childbirth-related posttraumatic stress symptoms have been associated with both constructs, we explored their possible mediation effect...
March 2018: Infant Mental Health Journal
https://www.readbyqxmd.com/read/29473161/depressive-symptoms-criticism-and-counter-criticism-in-marital-interactions
#12
Joseph M Trombello, Kristina M Post, David A Smith
Although people with depressive symptoms face criticism, hostility, and rejection in their close relationships, we do not know how they respond. Following interpersonal theories of depression, it might be expected that depressive symptoms would be associated with a tendency to receive and also to express criticism toward one's spouse, and that at least some of this criticism would be a contingent response to criticism received (i.e., "counter-criticism"). However, other research has determined that depressive symptoms/behaviors suppress partner criticism, suggesting that depressed people might respond to partner criticism similarly, by subsequently expressing less criticism...
February 23, 2018: Family Process
https://www.readbyqxmd.com/read/29466803/grandiose-and-vulnerable-narcissism-in-borderline-personality-disorder
#13
Sebastian Euler, Dominik Stöbi, Julia Sowislo, Franziska Ritzler, Christian G Huber, Undine E Lang, Johannes Wrege, Marc Walter
BACKGROUND: Little is known about narcissistic traits in borderline personality disorder (BPD). This exploratory study aimed to illustrate the associations between total, grandiose, and vulnerable narcissism and gender, diagnostic features of BPD and narcissistic personality disorder (NPD), and psychopathology in BPD patients. SAMPLING AND METHODS: The Pathological Narcissism Inventory and psychometric measures for impulsivity, anger, borderline symptom severity, personality organization, depression, and rejection sensitivity were completed by 65 BPD patients...
February 21, 2018: Psychopathology
https://www.readbyqxmd.com/read/29452000/optimal-items-for-assessing-sluggish-cognitive-tempo-in-children-across-mother-father-and-teacher-ratings
#14
Belén Sáez, Mateu Servera, Stephen P Becker, G Leonard Burns
A recent meta-analysis identified optimal items for assessing sluggish cognitive tempo (SCT) as distinct from attention deficit/hyperactivity disorder inattention (ADHD-IN), and a preliminary study with teacher ratings of children in the United States found strong support for the convergent and discriminant validity of 15 SCT items. The current study evaluated whether the same 15 SCT items demonstrated convergent and discriminant validity from ADHD-IN in a large, community-based sample of children in Spain, and whether validity results were replicated across mother, father, and teacher ratings...
February 16, 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29435948/racial-ethnic-discrimination-and-diabetes-related-outcomes-among-latinos-with-type-2-diabetes
#15
Alana M W LeBrón, Michael Spencer, Edith Kieffer, Brandy Sinco, Gloria Palmisano
Discrimination is associated with adverse health outcomes, but few studies have examined the association of discrimination with diabetes-related outcomes including mental health and glycemic control, particularly for immigrant and US-born Latinos. We analyzed survey data (n = 222) collected at baseline of a diabetes intervention. Using multiple linear regression, we examined the association of racial/ethnic discrimination with depressive symptoms, diabetes-related distress, and HbA1c, and variation in these associations by nativity and, for immigrants, length of US residence...
February 12, 2018: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29390992/traumatic-events-exploring-associations-with-maternal-depression-infant-bonding-and-oxytocin-in-latina-mothers
#16
Sandraluz Lara-Cinisomo, Kefu Zhu, Kexin Fei, Yumeng Bu, Alexandria P Weston, Uma Ravat
BACKGROUND: Childhood and adulthood traumatic experiences negatively impact maternal-infant bonding and increase risk of postpartum depression (PPD). Lower oxytocin levels have also been associated with PPD and compromised mother-infant bonding. Despite advances in these areas of investigation, much of the research has not included Latinas, who are important because they have high rates of fertility, traumatic events, and PPD. METHODS: To address gaps identified in the literature, we explored associations between traumatic life events, PPD, and bonding subscale scores (e...
February 1, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29372561/is-it-time-for-going-beyond-the-p-value-paradigm-with-the-estimation-of-the-probability-of-clinical-benefit-as-a-criterion-for-assessing-the-outcomes-of-a-clinical-trial-a-case-study-in-patients-with-major-depressive-disorder
#17
Roberto Gomeni, Françoise Bressolle-Gomeni, Maurizio Fava
The conventional statistical methodologies for evaluating treatment effect are based on hypothesis testing (P-value). Alternative measurements of treatment effect have been proposed for anti-infective treatments using the probability of target attainment. A general framework is proposed to extend this methodology to other therapeutic areas. A disease trial model is used for estimating the probability of reaching a treatment effect associated with relevant clinical benefits, in complement to the evaluation of the probability of rejecting the null hypothesis...
January 25, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29334035/neural-correlates-of-ostracism-in-transgender-persons-living-according-to-their-gender-identity-a-potential-risk-marker-for-psychopathology
#18
Sven C Mueller, Katrien Wierckx, Sara Boccadoro, Guy T'Sjoen
BACKGROUND: Stigmatization in society carries a high risk for development of psychopathology. Transgender persons are at particularly high risk for such stigmatization and social rejection by others. However, the neural correlates of ostracism in this group have not been captured. METHOD: Twenty transgender men (TM, female-to-male) and 19 transgender women (TW, male-to-female) already living in their gender identity and 20 cisgender men (CM) and 20 cisgender women (CW) completed a cyberball task assessing both exclusion and re-inclusion during functional magnetic resonance imaging (fMRI)...
January 15, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29327446/current-and-military-specific-gender-minority-stress-factors-and-their-relationship-with-suicide-ideation-in-transgender-veterans
#19
Raymond P Tucker, Rylan J Testa, Mark A Reger, Tracy L Simpson, Jillian C Shipherd, Keren Lehavot
Research suggests the prevalence of suicide ideation and suicide attempts in the transgender veteran community may be upwards of 20 times higher than nontransgender veterans, who are known to be at increased risk than the general US population. This study aimed to understand the potential influence of external and internal minority stress experienced during and after military service on past-year and recent suicide ideation in a sample of 201 transgender veterans. Nonparametric bootstrapping analyses indicated past-year transgender-specific discrimination and rejection (external minority stress) indirectly predicted frequency of both past-year and past 2-week suicide ideation through past-year shame related to gender identity (internal minority stress)...
January 12, 2018: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/29321700/validation-and-reliability-study-of-the-turkish-version-of-the-stigma-scale-of-epilepsy
#20
Nevin Kuloğlu Pazarci, Nihan Parasiz Yükselen, Şenay Aydın, Zeynep Ünlüsoy Acar, Dilek Necioğlu Örken
Introduction: We aimed to validate the Turkish version of the Stigma Scale of Epilepsy (SSE) (from Brazil) and present the results. Method: The SSE was completed by 33 patients with epilepsy (PWE), 25 of the patients' family members, and 23 people from the community. Subjects were interviewed on an individual basis; a physician read the questions and the subjects wrote the answers on a sheet. The form was the same for all subjects. In addition, the Beck Depression Inventory (BDI) and the Hamilton Anxiety Inventory (HAI), Short Form-36 (SF-36) were completed by the subjects...
December 2017: Noro Psikiyatri Arsivi
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