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Surgical pathology, Renal tumours, Pathology, Histopathology.

Gregory Pathrose, Nirmal Thampi John, Pradeep Hariharan
Synovial sarcoma is a soft tissue neoplasm with clearly defined histologic, immunohistochemical and molecular features. These tumours usually arise in the extremities of young adults. Their occurrence in the kidney is extremely rare. A 25-year-old pregnant lady in her first trimester was incidentally found to have a left renal mass on perinatal ultrasonography. MRI showed a well encapsulated, heterointense mass replacing the left kidney. Following medical termination of her pregnancy, a radical nephrectomy was performed...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
Johannes Breyer, Wolfgang Otto, Eva Maria Lausenmeyer, Stefan Denzinger, Ann-Kathrin Schwientek, Ludwig Ochs, Roman Mayr, Michael Gierth, Johannes Bründl, Maximilian Burger, Matthias Evert, Hans-Martin Fritsche, Christian Eichelberg
Introduction The incidence of renal cell carcinoma (RCC) has been increasing over the past few decades. Simultaneously, due to improved imaging, small renal masses at stage pT1 have been diagnosed more frequently. However, it is known that even small RCCs may recur and metastasize at a late point of time. This study aimed to identify easy-to-assess clinical and histopathological prognostic markers for long-term survival. Patients/Methods We performed a retrospective analysis of patients who underwent surgical treatment of a pT1 RCC in a single centre between 1993 and 2007...
May 2017: Aktuelle Urologie
Handoo Rhee, John Blazak, Chui Ming Tham, Keng Lim Ng, Benjamin Shepherd, Malcolm Lawson, John Preston, Ian Vela, Paul Thomas, Simon Wood
BACKGROUND: In this study, we prospectively evaluate the diagnostic potential of a gallium-68 (68Ga) prostate-specific membrane antigen (PSMA)-binding ligand and positron emission tomography (PET) in detecting metastatic lesions in patients with renal tumour. The secondary aim was to determine whether the findings would result in the alteration of patient management. RESULTS: Ten patients with renal lesion and potential metastatic disease on conventional imaging were recruited...
December 2016: EJNMMI Research
R Veeratterapillay, A Bromby, A Patel, A Sakthivel, A Abdelbakhy, B D Gowda, A Mutton, S Nagarajan, G P Naisby, A Bhatti
PURPOSE: To correlate the accuracy of intraoperative and surgical specimen (ex vivo) ultrasound (US) with pathological margin status at partial nephrectomy. MATERIALS AND METHODS: Patients undergoing partial nephrectomy for T1 renal tumours in the period May 2010-January 2014 at a single institution who had intraoperative specimen US were included. PN was performed by standardised technique with intraoperative tumour localisation. Following excision, surgical specimen (ex vivo) US was performed and the margin status was compared to the final histopathological analysis...
October 2015: International Urology and Nephrology
Marvin Sánchez-Coral, Jaime-Rodrigo Báez-Reyes, Eugenio García-Cano, Miguel Ángel Quintero-León, Edgar Cárdenas-Rodríguez, Alejandro Priego-Niño
BACKGROUND: Nephron -sparing surgery is currently the treatment of choice for surgical removal of solid renal tumours smaller than 7 cm, in the case of a solitary kidney, bilateral renal tumours or the presence of chronic renal failure. MATERIAL AND METHODS: An observational, descriptive, retrospective and cross-sectional study was conducted. The variables evaluated were: age at diagnosis, gender, intraoperative blood loss, operative time, preoperative tumour size, hospital stay, pathology report, pTNM classification, Fuhrman nuclear grade, pre- and post-operative creatinine, monitoring for cancer...
July 2015: Cirugia y Cirujanos
Havva Erdem, Hasan Riza Aydin, Anzel Bahadir, Betül Gündogdu, Hilal Balta, Ebru Sener, Muhammet Ali Kayikci, Aynur Albayrak, Fazli Erdogan
OBJECTIVE: To investigate the expression of cyclooxygenase-2 and cluster of differentiation 95 in renal cell carcinomas having different clinico-pathological characteristics. METHODS: The study entailed histopathological diagnoses carried out on paraffin blocks at the Department of Pathology of the Medical Hospital of Duzce University, Turkey, between 2005 and 2011. Immunohistochemical staining for cyclooxygenase-2 and cluster of differentiation 95was performed on tissue microarray using standard procedures...
June 2015: JPMA. the Journal of the Pakistan Medical Association
Nader Fahmy, Mark Woo, Mona Alameldin, Kyle Macdonald, Lee W Goneau, Peter Cadieux, Stephen E Pautler
INTRODUCTION: Ochratoxin-A (OTA) is one of the most abundant food-contaminating mycotoxins, known for its nephrotoxicity, neurotoxicity, gonadotoxicity, teratogenicity, immunosuppression and carcinogenesis. OTA has been linked to several genitourinary pathologies, including Balkan nephropathy and genitourinary malignancies. We examine OTA levels in serum samples and tumour specimens collected from patients with renal and testicular tumours. METHODS: Frozen samples were obtained from the Ontario Tumour Bank...
January 2014: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
W Y Khoder, S Siegert, C G Stief, A J Becker, R Waidelich
PURPOSE: Evaluation if cryoablation of small renal tumours (RT) would facilitate the technique of laparoscopic partial nephrectomy (LPN) in a prospective study. PATIENTS AND METHODS: In a prospective non-randomised study between April 2007 and October 2009, 16 patients with a mean age of 68 years (48-80 years) and a peripherally located RT were candidates for nephron-sparing surgery (5 open partial nephrectomy (OPN), 11 LPN). Cryoablation of RT was followed in the same session by open (K-OPN) and laparoscopic (K-LPN) partial nephrectomy...
January 2014: European Journal of Surgical Oncology
C von Klot, J U Becker, V Grünwald, I Peters, M A Kuczyk, A S Merseburger
We report on a 66-year-old female patient, presenting with a renal mass of 7.1 cm diameter on CT scan indicative of malignancy in the left solitary kidney. At first, the attempt at an open partial nephrectomy was undertaken. The intraoperative findings, however, did not allow for a kidney-preserving surgical procedure, mostly due to the close proximity of the tumour to the hilar vessels. The histopathology obtained during the procedure showed a clear cell renal cell carcinoma. Thus, systemic therapy with sunitinib over a period of 70 days (2 cycles/50 mg p...
September 2012: Aktuelle Urologie
Cuijian Zhang, Xuesong Li, Han Hao, Wei Yu, Zhisong He, Liqun Zhou
UNLABELLED: What's known on the subject? and What does the study add? We had known from former studies of RCC that the risks of high grade tumours increased with tumour size and probability of localized tumour decreased with tumour size increasing. Our study had provided large and detailed data about pathologic features of RCC. We also examined the exactly changing of probabilities of different subtypes with diameter increasing and evaluated the effects of hemorrhage, necrosis and cystic degeneration on pathologic subtypes...
December 2012: BJU International
Catherine R Harris, Jared M Whitson, Maxwell V Meng
UNLABELLED: What's known on the subject? and What does the study add? It is well documented that biopsy of small renal masses is inaccurate and tends to under-estimate tumour grade compared with surgical specimens. To our knowledge there has not been a study showing grading discrepancy between biopsy and surgical excision in a large population-based cohort. OBJECTIVE: To determine whether differences exist in tumour grade between patients who undergo partial nephrectomy (PN) and those who undergo ablation for renal tumours...
September 2012: BJU International
Muhammed Mubarak, Javed I Kazi, Rehan Mohsin, Altaf Hashmi, Syed Ali Anwer Naqvi, Syed Adeeb Ul Hassan Rizvi
BACKGROUND: There is no data on the histopathological characteristics of renal tumours in young adults in Pakistan. MATERIALS AND METHODS: We retrospectively analysed 133 young adults (age: 16 to ≤40 years) who underwent nephrectomy for suspected renal cancer from 1994 till July 2010. The demographical and pathological parameters were determined from original surgical biopsy reports and case files, and analysed. RESULTS: The mean age of patients was 33...
February 2012: Journal of Cancer Research and Clinical Oncology
Evelyne C C Cauberg, Maartje A Salomons, Intan P E D Kümmerlin, Theo M de Reijke, Aeilko H Zwinderman, Jean J M C H de la Rosette, Fiebo J W Kate, M Pilar Laguna Pes
OBJECTIVE: To evaluate changes in incidence, distribution of stage and grade as well as surgical treatment of upper urinary tract (UUT) tumours in the Netherlands from 1995 to 2005. PATIENTS AND METHODS: The PALGA registry, a nationwide network and registry of pathology encompassing all hospitals in the Netherlands, was used as primary data source. Pathology reports of all primary surgical procedures or biopsies without further surgical treatment within the next year, of cancer of the renal pelvis or ureter during the period 1995-2005, were included...
April 2010: BJU International
Jong Wook Park, Moon Ki Jo, Hyun Moo Lee
OBJECTIVES: To evaluate the role of (18)F-fluorodeoxyglucose (FDG) positron-emission tomography (PET)/computed tomography (CT) for the surveillance of patients with renal cell carcinoma (RCC) who have a high risk of local recurrence or distant metastasis, by comparing the results with those of conventional imaging methods. PATIENTS AND METHODS: Sixty-three patients with RCC had conventional imaging studies and FDG PET/CT during the follow-up after surgical treatment...
March 2009: BJU International
Intan P E D Kümmerlin, Fiebo J W ten Kate, Hessel Wijkstra, Jean J M C H de la Rosette, M Pilar Laguna
OBJECTIVE: To evaluate changes in the pathological characteristics, stage of primary renal tumours and their surgical management in the Netherlands during the period 1995-2005. METHODS: Extracts from the records of all patients who had surgery for primary renal tumours in the Netherlands during the period 1995-2005 were reviewed. Data were collected from PALGA, the nationwide network and archive of histocytopathology. The 2002 Tumour-Node-Metastasis and the three-tier Fuhrman grade were used for staging and grading...
September 2008: BJU International
L Gómez Pérez, A Budía Alba, F J Delgado Oliva, J L Ruiz Cerda, M Trassiera Villa, F Jiménez Cruz
OBJECTIVE: to evaluate the clinical and pathological renal cancer (CR) characteristics in our series of tumours, analyzing its impact in the group of age less than 40 years. MATERIAL AND METHODS: We studied 294 patients with CR. The pathologic characteristics were analyzed and DNA ploidy pattern of the surgical pieces were done in 252 patients. The patients were divided in two groups based on age, greater or less to 40 years, well then clinical and pathologic characteristics were compared between...
March 2007: Actas Urologicas Españolas
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