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sleep apnea esrd

Loheetha Ragupathi, Drew Johnson, Gregary D Marhefka
Surgically created arteriovenous fistulae (AVF) for hemodialysis can contribute to hemodynamic changes. We describe the cases of 2 male patients in whom new right ventricular enlargement developed after an AVF was created for hemodialysis. Patient 1 sustained high-output heart failure solely attributable to the AVF. After AVF banding and subsequent ligation, his heart failure and right ventricular enlargement resolved. In Patient 2, the AVF contributed to new-onset right ventricular enlargement, heart failure, and ascites...
August 2016: Texas Heart Institute Journal
Adrian P Abreo, Lorien S Dalrymple, Glenn M Chertow, George A Kaysen, Charles A Herzog, Kirsten L Johansen
Introduction Previous studies of patients with end-stage renal disease have examined the role of fluid shifts on apnea-hypopnea episodes, but the association between volume overload and patient-reported sleep quality or duration has not been well-established. Methods We studied the association between predialysis bioimpedance spectroscopy-derived volume estimates and self-reported sleep quality and duration in 638 patients in the United States Renal Data System ACTIVE/ADIPOSE study receiving hemodialysis from 2009 to 2011...
June 27, 2016: Hemodialysis International
Rosilene M Elias, Christopher T Chan, T Douglas Bradley
OBJECTIVE: Although symptoms of sleep disturbances are widely recognized in end-stage renal disease (ESRD), the effect of uremia on sleep structure has not been well investigated. We hypothesized that compared to individuals without ESRD, those with ESRD would have altered sleep structure after controlling for the severity of sleep apnea (SA). METHODS: We studied 57 ESRD patients (42 men) and 57 controls (46 men) who had undergone polysomnography. Control subjects were matched to the ESRD patients by age, body mass index (BMI), frequency of periodic leg movements per hour of sleep, and the frequency of apneas and hypopneas per hour of sleep [apnea-hypopnea index (AHI)]...
April 2016: Sleep Medicine
C Vaughan Tuohy, Maria E Montez-Rath, Mintu Turakhia, Tara I Chang, John W Winkelman, Wolfgang C Winkelmayer
BACKGROUND: Sleep disordered breathing (SDB) such as sleep apnea is associated with cardiovascular disease in the general population. However, little is known about the cardiovascular risks of SDB in patients with end-stage renal disease (ESRD). METHODS: We identified Medicare fee-for-service beneficiaries aged ≥67 years initiating dialysis between 2004 and 2009. Outcomes of interest included all-cause mortality, incident myocardial infarction, ischemic stroke, and atrial fibrillation...
2016: BMC Nephrology
Gaurav Nigam, Charu Pathak, Muhammad Riaz
BACKGROUND: Obstructive sleep apnea has been widely studied in patients with chronic renal insufficiency; however only a limited number of studies have reviewed the association between central sleep apnea (CSA) and chronic kidney disease (CKD). The objectives of this systematic review were to assess the prevalence of CSA in and its association with CKD in adult patients and to determine if inclusion of the central hypopnea index affected the reported rates for the prevalence of CSA in CKD...
September 2016: Sleep & Breathing, Schlaf & Atmung
Siraj Omar Wali, Abeer Alkhouli, Mohannad Howladar, Ibrahim Ahmad, Saad Alshohaib, Saeed Al-Ghamdi, Ayman Krayem
AIM: The prevalence of obstructive sleep apnea (OSA) in end-stage renal disease (ESRD) patients was reported to be 10-fold that in the general population. OSA can worsen the clinical symptoms and cardiovascular complications of ESRD. We aimed to investigate the prevalence of symptoms and risk of OSA among Saudi patients with ESRD. SETTINGS AND DESIGN: This multi-center, cross-sectional study was conducted in Jeddah, Saudi Arabia, between June 2012 and September 2013...
October 2015: Annals of Thoracic Medicine
Afsoon Emami Naini, Babak Amra, Leila Mahmoodnia, Shahram Taheri
BACKGROUND: This study was aimed to evaluate the prevalence of obstructive sleep apnea (OSA) and restless legs syndrome (RLS) in patients with end-stage renal disease (ESRD) after kidney transplantation. MATERIALS AND METHODS: Two hundred kidney transplant recipients were enrolled in this cross-sectional study. Data on age, gender, etiology of ESRD, history of previous kidney transplantation, serum creatinine, and the presence or absence of OSA and RLS were collected...
2015: Advanced Biomedical Research
Owen D Lyons, T Douglas Bradley, Christopher T Chan
In end-stage renal disease (ESRD) and heart failure, conditions characterized by fluid overload, both obstructive sleep apnea (OSA) and central sleep apnea (CSA) are highly prevalent. This observation suggests that fluid overload may be a unifying mechanism in the pathogenesis of both OSA and CSA in these conditions. An overnight rostral fluid shift from the legs to the neck and lungs has been shown to contribute to the pathogenesis of OSA and CSA, respectively, in various different patient populations. This article reviews the evidence that supports a role for fluid overload and overnight fluid shift in the pathogenesis of sleep apnea in ESRD...
July 2015: Seminars in Nephrology
Sushma M Dharia, Mark L Unruh, Lee K Brown
Sleep is an essential function of life and serves a crucial role in the promotion of health and performance. Poor sleep quality and sleep disorders have been a recurrent finding in patients with chronic kidney disease (CKD). Sleep disorders such as obstructive sleep apnea (OSA) can contribute to hypertension, diabetes, cardiovascular disease, and worsen obesity, all of which are implicated in the etiology of CKD, but CKD itself may lead to OSA. Relationships between CKD/end-stage renal disease (ESRD) and OSA have been the subject of numerous investigations, but central sleep apnea (CSA) also is highly prevalent in CKD/ESRD but remains poorly understood, underdiagnosed, and undertreated in these patients...
July 2015: Seminars in Nephrology
Jae-Kwan Song
Infective endocarditis (IE) has been increasingly diagnosed in patients without previously detected predisposing heart disease, but its clinical features have yet to be fully determined. A recent single-center study including echocardiographic images and surgical findings investigated the incidence of undiagnosed, clinically silent valvular or congenital heart diseases and healthcare-associated infective endocarditis (HAIE). The study confirmed that a large proportion of patients with IE have no previous history of heart disease...
July 2015: Korean Journal of Internal Medicine
Yehuda Handelsman, Zachary T Bloomgarden, George Grunberger, Guillermo Umpierrez, Robert S Zimmerman, Timothy S Bailey, Lawrence Blonde, George A Bray, A Jay Cohen, Samuel Dagogo-Jack, Jaime A Davidson, Daniel Einhorn, Om P Ganda, Alan J Garber, W Timothy Garvey, Robert R Henry, Irl B Hirsch, Edward S Horton, Daniel L Hurley, Paul S Jellinger, Lois Jovanovič, Harold E Lebovitz, Derek LeRoith, Philip Levy, Janet B McGill, Jeffrey I Mechanick, Jorge H Mestman, Etie S Moghissi, Eric A Orzeck, Rachel Pessah-Pollack, Paul D Rosenblit, Aaron I Vinik, Kathleen Wyne, Farhad Zangeneh
UNLABELLED: The American Association of Clinical Endocrinologists/American College of Endocrinology Medical Guidelines for Clinical Practice are systematically developed statements to assist healthcare professionals in medical decision making for specific clinical conditions. Most of the content herein is based on literature reviews. In areas of uncertainty, professional judgment was applied. These guidelines are a working document that reflects the state of the field at the time of publication...
April 2015: Endocrine Practice
Abhishek Dubey, Surya Kant, Sunita Tiwari, Sarita Agarwal, Abbas Ali Mahdi
BACKGROUND: Leptin takes part in regulation of energy balance, neuronal functions, pain and mood. It may act as intermediary marker for various components of HRQOL in patients of obstructive sleep apnea syndrome. AIMS: To document the correlation among leptin levels, obesity and HRQoL in OSAS patients. METHODS: A tertiary care hospital based cross-sectional study was done in 224 subjects aged 18-65 years, after taking informed consent. Subjects with previous history of smoking, Liver disease, COPD, CHD, T2 DM, asthma, cancer, end stage renal disease, heart failure, any endocrine disorder including Cushing syndrome, thyroid, on systemic steroid or any continuous medication for last 6 months, on dieting or suffering from any disability condition (other than obesity and OSAS) affecting their HRQoL were excluded from the study...
April 2015: Indian Journal of Tuberculosis
G Mancia, F Mahfoud, K Narkiewicz, L M Ruilope, M P Schlaich, R E Schmieder, B Williams, M Böhm
OBJECTIVE: The Global SYMPLICITY Registry (GSR) provides real world experience regarding the effects of radiofrequency denervation of the renal artery nerves in patients with uncontrolled hypertension. These data in hypertensive patients with a high proportion of concomitant conditions also characterized by sympathetic nervous system will further characterize the effects of renal denervation across a diverse patient population. DESIGN AND METHOD: The GSR is a prospective, open-label, registry being conducted at 245 international sites...
June 2015: Journal of Hypertension
Haitham Ezzat, Amr Mohab
Sleep disorders are common among the patients undergoing dialysis in end stage renal disease (ESRD). Although variable, their prevalence has been reported to be higher when compared to the general population. The most frequently reported complaints are insomnia, restless leg syndrome (RLS), sleep-disordered breathing and excessive daytime sleepiness (EDS). The aim of this study was to assess the prevalence of sleep disorders in end stage renal disease patients on regular hemodialysis (group I with 30 patients) and CKD patients (group II with 30 patients) in comparison to 30 normal population (control group)...
July 2015: Renal Failure
Maria-Eleni Roumelioti, Lee K Brown, Mark L Unruh
Obstructive sleep apnea (OSA) is common, underdiagnosed, and undertreated among patients with end-stage renal disease (ESRD). As in all cases, pathogenesis of OSA is related to repeated upper airway (UA) occlusion or narrowing, but in ESRD, additional contributory factors likely include uremic destabilization of central respiratory control and anatomic changes in the UA related to fluid status. Pulmonary congestion is common in acute and chronic kidney failure and is a consequence of cardiomyopathy and fluid overload, two potentially reversible risk factors...
September 2015: Seminars in Dialysis
Adam Ogna, Valentina Forni Ogna, Alexandra Mihalache, Menno Pruijm, Georges Halabi, Olivier Phan, Françoise Cornette, Isabelle Bassi, José Haba Rubio, Michel Burnier, Raphaël Heinzer
BACKGROUND AND OBJECTIVES: Obstructive sleep apnea is associated with significantly increased cardiovascular morbidity and mortality. Fluid overload may promote obstructive sleep apnea in patients with ESRD through an overnight fluid shift from the legs to the neck soft tissues. Body fluid shift and severity of obstructive sleep apnea before and after hemodialysis were compared in patients with ESRD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Seventeen patients with hemodialysis and moderate to severe obstructive sleep apnea were included...
June 5, 2015: Clinical Journal of the American Society of Nephrology: CJASN
Bisher Abuyassin, Kumar Sharma, Najib T Ayas, Ismail Laher
Chronic kidney disease (CKD) is associated with high mortality rates and heavy economic and social burdens. Nearly 10% of the United States population suffer from CKD, with fatal outcomes increased by 16-40 times even before reaching end-stage renal disease. The prevalence of obstructive sleep apnea (OSA) is between 3% and 7% in the general population, and has increased dramatically during the last 2 decades along with increased rates of obesity. However, the prevalence of OSA is much greater in patients with CKD...
August 2015: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Owen D Lyons, Christopher T Chan, Azadeh Yadollahi, T Douglas Bradley
RATIONALE: In end-stage renal disease (ESRD), a condition characterized by fluid overload, both obstructive and central sleep apnea (OSA and CSA) are common. This observation suggests that fluid overload is involved in the pathogenesis of OSA and CSA in this condition. OBJECTIVES: To test the hypothesis that fluid removal by ultrafiltration (UF) will reduce severity of OSA and CSA in patients with ESRD. METHODS: At baseline, on a nondialysis day, patients with ESRD on thrice-weekly hemodialysis underwent overnight polysomnography along with measurement of total body extracellular fluid volume (ECFV), and ECFV of the neck, thorax, and right leg before and after sleep...
June 1, 2015: American Journal of Respiratory and Critical Care Medicine
Siraj O Wali, Abeer F Alkhouli
OBJECTIVES: To determine the prevalence of restless legs syndrome (RLS) in Saudi patients with end-stage renal disease (ESRD) on hemodialysis. METHODS: A cross-sectional study was carried out in 3 hemodialysis centers in Jeddah, Saudi Arabia, between June 2012 and September 2013. All patients were individually interviewed and data was collected on the following: demographic features, medical history, laboratory test, the International Restless Legs Syndrome Study Group questionnaire, Epworth Sleepiness Scale (ESS), and Berlin Questionnaire...
February 2015: Saudi Medical Journal
Yi-Che Lee, Shih-Yuan Hung, Hao-Kuang Wang, Chi-Wei Lin, Hsi-Hao Wang, Shih-Wei Chen, Min-Yu Chang, Li-Chun Ho, Yi-Ting Chen, Hung-Hsiang Liou, Tsuen-Chiuan Tsai, Shih-Hann Tseng, Wei-Ming Wang, Sheng-Hsiang Lin, Yuan-Yow Chiou
STUDY OBJECTIVES: Sleep apnea (SA) is characterized by apnea during sleep and is associated with cardiovascular diseases and an increase in all-cause mortality. Chronic kidney disease (CKD) is a global health problem that has placed a substantial burden on healthcare resources. However, the relationship between SA and the incidence of CKD is not clear. This study aimed to determine whether SA is an independent risk factor for the development of CKD. DESIGN: Retrospective cohort study...
2015: Sleep
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