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https://www.readbyqxmd.com/read/29222402/elmod1-stimulates-arf6-gtp-hydrolysis-to-stabilize-apical-structures-in-developing-vestibular-hair-cells
#1
Jocelyn F Krey, Rachel A Dumont, Philip A Wilmarth, Larry L David, Kenneth R Johnson, Peter G Barr-Gillespie
Sensory hair cells require control of physical properties of their apical plasma membranes for normal development and function. Members of the ARF small GTPase family regulate membrane trafficking and cytoskeletal assembly in many cells. We identified ELMOD1, a guanine nucleoside triphosphatase activating protein (GAP) for ARF6, as the most highly enriched ARF regulator in hair cells. To characterize ELMOD1 control of trafficking, we analyzed mice of both sexes from a strain lacking functional ELMOD1 (roundabout; rda)...
December 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29181098/characterization-of-hair-follicle-side-population-cells-in-mouse-epidermis-and-skin-tumors
#2
Sun Hye Kim, Christopher Sistrunk, Paula L Miliani de Marval, Marcelo L Rodriguez-Puebla
A subset of cells, termed side-population (SP), which have the ability to efflux Hoeschst 33342, have previously been demonstrated to act as a potential method to isolate stem cells. Numerous stem/progenitor cells have been localized in different regions of the mouse hair follicle (HF). The present study identified a SP in the mouse HF expressing the ABCG2 transporter and MTS24 surface marker. These cells are restricted to the upper isthmus of the HF and have previously been described as progenitor cells. Consistent with their SP characteristic, they demonstrated elevated expression of ABCG2 transporter, which participates in the dye efflux...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29154796/treatment-of-cancer-by-low-intensity-laser-radiation-therapy
#3
REVIEW
Sahar E Abo-Neima
Cancer treatment is one of the main challenges that face the scientific centers all over the world. The cancer incidence percentage increases year after year. The most used treatment for cancer is chemotherapy which is an application of systemic cytotoxic drug inside the patient. There are two main problems in chemotherapy that the cytotoxic drug is given systematically and cannot be localized in the tumor region in most cases that lead to killing the cancer cells as well as normal cells; and that cause the chemotherapy side effects like anemia, decrease in all blood cells count and platelets, nausea, vomiting, diarrhea, hair and nails loss and may cause a kind of blood toxicity...
November 14, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/29115940/does-hair-dye-use-really-increase-the-risk-of-prostate-cancer
#4
Bang-Ping Jiann
Recently, Shu-Yu Tai et al. reported that personal hair dye use increased risk of prostate cancer with a dose-response effect. Although hair dyes were identified as carcinogenic in animals and increased risk of some cancers among hairdressers, the existing epidemiological data did not support that personal hair dye use increased risk of cancers, even for bladder cancer. Given that Tai et al.'s report of a potential hazard of personal hair dye use on risk of prostate cancer was particular, the methodology of the study was scrutinized and some flaws were found including the issue of external validity...
November 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29029920/mitigation-or-prevention-of-mild-hair-dye-contact-dermatitis-after-pretreatment-with-clobetasol-foam
#5
Jace Rickstrew, Ting Wang, Deede Liu, Anand Rajpara, Daniel J Aires
No abstract text is available yet for this article.
November 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28970593/occupations-and-the-risk-of-bladder-cancer-in-yazd-province-a-case-control-study
#6
Fatemeh Farzaneh, Amir Houshang Mehrparvar, Mohammad Hassan Lotfi
BACKGROUND: Bladder cancer is the most common cancer of the urinary tract, with known occupational causes. The most effective way to prevent occupational cancers of the urinary tract is to prevent exposure to known carcinogens. OBJECTIVE: To examine the relationship between occupation and the risk of bladder cancer. METHODS: This case-control study was performed on 200 patients with bladder cancer and 200 healthy individuals in Yazd. Data were collected using a researcher-made questionnaire and based on interviews with patients and controls...
October 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28969253/patch-test-results-from-an-occupational-and-contact-dermatitis-clinic-in-a-tertiary-care-hospital-of-southern-india-a-retrospective-study
#7
Kumaravel Sadagopan, Deepa Kalappan, Nirmala Sivaprakasam, Vinoth
INTRODUCTION: Occupational contact dermatitis, accounting for 95% of cases of occupational dermatoses, is the most common occupational skin disease. AIM: To find out the various allergens in different occupational and environmental settings causing contact allergy, from our patients presented with contact dermatitis. MATERIALS AND METHODS: It was a retrospective study from the data in hospital outpatient register over one year period, which includes patients with age ranging from 11 years to 73 years...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28961320/self-testing-for-contact-allergy-to-hair-dyes%C3%A2-%C3%A2-a-5-year-follow-up-multicentre-study
#8
Ulrik F Friis, An Goosens, Ana Maria Giménez-Arnau, Carola Lidén, Elena Giménez-Arnau, Ian R White, Jose H Alfonso, Wolfgang Uter, Jeanne D Johansen
BACKGROUND: In 2011, a multicentre study was conducted in order to determine how hair dye manufacturers instructed consumers to perform a self-test prior to dyeing their hair, in order to identify individuals who are likely to react upon subsequent hair dyeing. A number of concerns were raised concerning the variability in instructions between products and producers, and the safety and validity of this tool. OBJECTIVES: To perform a 5-year follow-up study in order to determine whether manufacturers still recommend a self-test, and if so, whether the procedures have been changed...
September 29, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28946126/tryptophan-and-kynurenine-determination-in-human-hair-by-liquid-chromatography
#9
Michelli F Dario, Thamires Batello Freire, Claudinéia Aparecida Sales de Oliveira Pinto, María Segunda Aurora Prado, André R Baby, Maria Valéria R Velasco
Tryptophan, an amino acid found in hair proteinaceous structure is used as a marker of hair photodegradation. Also, protein loss caused by several chemical/physical treatments can be inferred by tryptophan quantification. Kynurenine is a photo-oxidation product of tryptophan, expected to be detected when hair is exposed mainly to UVB (290-320nm) radiation range. Tryptophan from hair is usually quantified directly as a solid or after alkaline hydrolysis, spectrofluorimetrically. However, these types of measure are not sufficiently specific and present several interfering substances...
October 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28940782/ptca-1h-pyrrole-2-3-5-tricarboxylic-acid-as-a-marker-for-oxidative-hair-treatment
#10
Silvana Petzel-Witt, Sylvia I Meier, Manfred Schubert-Zsilavecz, Stefan W Toennes
Hair analysis for the assessment of alcohol or drug abstinence became a routine procedure in forensic toxicology. Hair coloration leading to loss of incorporated xenobiotics and to false negative results turned out to be a major problem. Currently only colored extracts provide hints of manipulations but not bleaching. A liquid chromatographic-mass spectrometric (LC-MSMS) method was developed and validated to determine 1H-pyrrole-2,3,5-tricarboxylic acid (PTCA), a major oxidation product of melanin. PTCA was determined in natural hair samples (n=21) after treatment with 3% hydrogen peroxide (H2 O2 ) for 30 or 40 min with concentrations up to 12% for 40 min...
September 20, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28927536/reflections-on-a-career-and-on-the-history-of-genetic-toxicity-testing-in-the-national-toxicology-program
#11
Errol Zeiger
One of the highly visible aspects of the U.S. National Toxicology Program (NTP) has been its genetic toxicity testing program, which has been responsible for testing, and making publicly available, in vitro and in vivo test data on thousands of chemicals since 1979. What is less well known, however, is that this NTP program had its origin in two separate testing programs that were initiated independently at the National Cancer Institute (NCI) and the National Institute of Environmental Health Sciences (NIEHS) before the NTP was established...
July 2017: Mutation Research
https://www.readbyqxmd.com/read/28925101/personal-use-of-hair-dyes-and-risk-of-leukemia-a-systematic-literature-review-and-meta-analysis
#12
REVIEW
Kevin M Towle, Matthew E Grespin, Andrew D Monnot
The objective of this study was to examine the association between personal use of hair dyes and the risk of leukemia. We conducted a systematic literature review of epidemiology studies reporting leukemia-specific cancer risks among hair dye users, and estimated the meta-relative risk (meta-RR) and corresponding 95% confidence interval (95% CI) of leukemia, comparing hair dye users to nonusers. When data from all 20 studies that met the inclusion criteria were combined, ever use of hair dye was associated with a nonstatistically significant increased risk of leukemia, meta-RR = 1...
October 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28912796/a-low-cost-imaging-method-for-the-temporal-and-spatial-colorimetric-detection-of-free-amines-on-maize-root-surfaces
#13
Truc H Doan, Tu A Doan, Michael J Kangas, AdreAnna E Ernest, Danny Tran, Christina L Wilson, Andrea E Holmes, Erin L Doyle, Tessa L Durham Brooks
Plant root exudates are important mediators in the interactions that occur between plants and microorganisms in the soil, yet much remains to be learned about spatial and temporal variation in their production. This work outlines a method utilizing a novel colorimetric paper to detect spatial and temporal changes in the production of nitrogen-containing compounds on the root surface. While existing methods have made it possible to conduct detailed analysis of root exudate composition, relatively less is known about where in the root system exudates are produced and how this localization changes as the root grows...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28910945/-nested-case-control-study-on-associated-factors-for-anemia-during-pregnancy
#14
C L Fan, J Y Luo, W J Gong, X Q Liu, S J Zhou, F F Zhang, J Zeng, H X Li, N Feng
Objective: To explore the related factors of anemia during pregnancy and provide scientific evidence for the primary prevention of anemia during pregnancy. Methods: The pregnant women (≤12 pregnant weeks) who received the first pregnancy care in a local medical institution in Hunan province from June 2013 to November 2014 were included in this cohort study, and for them anemia had been excluded by physical examination. Baseline survey and follow up till childbirth were conducted for them. A queue-based nested case-control study (1 ∶ 2) was conducted (380 pregnant women with anemia detected in this study as case group, 760 pregnant women without anemia randomly selected and matched by age, habitual residence during pregnancy as control group...
September 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28898818/the-impact-of-demographic-factors-behaviors-and-environmental-exposure-to-mercury-content-in-the-hair-of-the-population-living-in-the-region-of-lodz-central-poland
#15
Marta Marcinek-Jacel, Jadwiga Albińska, Aleksandra Pawlaczyk, Małgorzata Iwona Szynkowska
The aim of this work was to access the influence of different factors such as sex, age, fish consumption, hair dyeing or smoking habit on the content of mercury in human hair samples. The research was carried on 444 samples (102 males and 342 females) collected from the population of people living in the region of Lodz (central Poland). The content of mercury in human hair samples was determined using the Mercury Analyzer MA 3000 (Nippon Instruments, Japan). The obtained results were elaborated using Statistica ver...
September 5, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28872198/allergic-contact-urticaria-secondary-to-hair-dye-use
#16
Rachel Montgomery, Mark Wilkinson
No abstract text is available yet for this article.
October 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28795423/hairdressers-skin-exposure-to-hair-dyes-during-different-hair-dyeing-tasks
#17
Marie-Louise Lind, Stina Johnsson, Carola Lidén, Birgitta Meding, Anders Boman
BACKGROUND: The high risk of occupational skin disease among hairdressers, caused by skin exposure to irritants and sensitizers, such as hair dye substances, is of great concern. OBJECTIVES: The aim of the present study was to assess how the various tasks involved in hair dyeing contribute to hairdressers' exposure to hair dye, in order to enable the formulation of well-founded recommendations on working routines that will reduce exposure and prevent occupational disease...
August 9, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28766798/assessment-of-skin-sensitization-potency-of-hair-dye-molecules-in-vitro
#18
Jennifer Hennen, Brunhilde Blömeke
No abstract text is available yet for this article.
September 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28711639/skin-permeability-enhancement-by-bacillus-subtilis-alkaline-protease-application-to-transdermal-drug-delivery
#19
Mohamed I Nounou, Taha I Zaghloul, Nehal A Ahmed, Amira A Eid, Labiba K El-Khordagui
Enzymes may offer great potentials in topical pharmaceutical applications provided that treatment conditions are controlled for efficacy and safety. In this study, the effect of alkaline protease produced by recombinant Bacillus subtilis cells on the ex-vivo permeability of rabbit ear skin was investigated under different conditions of enzyme activity (5-60 units) and exposure time (15-60min). Data for transepidermal water loss (TEWL) and permeation of a hydrophilic dye, rhodamine B (Rb), indicated biphasic activity-dependent and exposure time-dependent skin permeability...
July 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28703343/contact-anaphylaxis-caused-by-basic-blue-99-in-hair-dye
#20
Ken Washio, Keiko Ijuin, Atsushi Fukunaga, Hiroshi Nagai, Chikako Nishigori
No abstract text is available yet for this article.
August 2017: Contact Dermatitis
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