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https://www.readbyqxmd.com/read/28711639/skin-permeability-enhancement-by-bacillus-subtilis-alkaline-protease-application-to-transdermal-drug-delivery
#1
Mohamed I Nounou, Taha I Zaghloul, Nehal A Ahmed, Amira A Eid, Labiba K El-Khordagui
Enzymes may offer great potentials in topical pharmaceutical applications provided that treatment conditions are controlled for efficacy and safety. In this study, the effect of alkaline protease produced by recombinant Bacillus subtilis cells on the ex-vivo permeability of rabbit ear skin was investigated under different conditions of enzyme activity (5-60 units) and exposure time (15-60min). Data for transepidermal water loss (TEWL) and permeation of a hydrophilic dye, rhodamine B (Rb), indicated biphasic activity-dependent and exposure time-dependent skin permeability...
July 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28703343/contact-anaphylaxis-caused-by-basic-blue-99-in-hair-dye
#2
Ken Washio, Keiko Ijuin, Atsushi Fukunaga, Hiroshi Nagai, Chikako Nishigori
No abstract text is available yet for this article.
August 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28683402/different-roles-of-glutathione-in-copper-and-zinc-chelation-in-brassica-napus-roots
#3
Ilya E Zlobin, Alexander V Kartashov, George V Shpakovski
We investigated the specific features of copper and zinc excess action on the roots of canola (Brassica napus L.) plants. Copper rapidly accumulated in canola root cells and reached saturation during several hours of treatment, whereas the root zinc content increased relatively slowly. Excessive copper and zinc entry inside the cell resulted in significant cell damage, as evidenced by alterations in plasmalemma permeability and decreases in cellular enzymatic activity. Zinc excess specifically damaged root hair cells, which correlated with a pronounced elevation of their labile zinc level...
June 28, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28682191/blood-zinc-levels-in-nursing-women-from-different-regions-of-the-west-bank-of-palestine
#4
Ramzi Shawahna, Ahed Zyoud, Donia Jallad, Labebah Hadwan, Neeran Ihssan, Hikmat Hilal
Pregnant and nursing women are at higher risk of zinc deficiency which can have detrimental consequences on health. We assessed blood zinc levels in 72 nursing women from the West Bank of Palestine and investigated the association between sociodemographic variables and blood zinc levels. Blood samples were analyzed for their zinc contents using graphite furnace atomic absorption spectrophotometry. Blood and data collection were performed between July and December 2016. The median blood zinc level was 4.53 mg/L (IQR of 0...
July 6, 2017: Women & Health
https://www.readbyqxmd.com/read/28675503/a-population-based-study-of-self-reported-skin-exposures-and-symptoms-in-relation-to-contact-allergy-in-adolescents
#5
Maria Lagrelius, Carl-Fredrik Wahlgren, Mihály Matura, Anna Bergström, Inger Kull, Carola Lidén
BACKGROUND: Knowledge about the relations between skin exposures, skin symptoms and contact allergy in adolescents is limited. OBJECTIVES: To explore self-reported skin exposures and skin symptoms in girls and boys, and to assess the associations between exposures, symptoms and contact allergy at age 16 years. PARTICIPANTS AND METHODS: In all, 3115 adolescents from the population-based BAMSE birth cohort answered a questionnaire at age 16 concerning various skin exposures and related skin symptoms...
July 4, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28611994/common-allergens-identified-based-on-patch-test-results-in-patients-with-suspected-contact-dermatitis-of-the-scalp
#6
Nouf M Aleid, Raymond Fertig, Austin Maddy, Antonella Tosti
BACKGROUND: Contact dermatitis of the scalp is common and might be caused by many chemicals including metals, ingredients of shampoos and conditioners, dyes, or other hair treatments. Eliciting a careful history and patch tests are necessary to identify the responsible allergen and prevent relapses. OBJECTIVES: To identify allergens that may cause contact dermatitis of the scalp by reviewing patch test results. METHODS: We reviewed the records of 1,015 patients referred for patch testing at the Dermatology Department of the University of Miami...
March 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28605409/hair-product-use-and-breast-cancer-risk-among-african-american-and-white-women
#7
Adana A M Llanos, Anna Rabkin, Elisa V Bandera, Gary Zirpoli, Brian D Gonzalez, Cathleen Y Xing, Bo Qin, Yong Lin, Chi-Chen Hong, Kitaw Demissie, Christine B Ambrosone
Exposures to carcinogens in hair products have been explored as breast cancer risk factors, yielding equivocal findings. We examined hair product use (hair dyes, chemical relaxers and cholesterol or placenta-containing conditioners) among African American (AA) and White women, and explored associations with breast cancer. Multivariable-adjusted models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) to describe the associations of interest among 2,280 cases (1,508 AA and 772 White) and 2,005 controls (1,290 AA and 715 White)...
June 9, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28586750/microbial-decolorization-and-detoxification-of-emerging-environmental-pollutant-cosmetic-hair-dyes
#8
Swati Maiti, Sudarson Sekhar Sinha, Mukesh Singh
Since the usage of hair dyes has increased in recent time, the removal of residual dye from environment is also an emerging issue. Hair dye contains mixture of chemicals including genotoxic chemical, p-phenylenediamine (p-PD or PPD). The present study reports bioremediation of hair dye using bacteria isolated from saloon effluent. Sugarcane bagasse powder (SBP) was used as a source of nutrient and surface for bacterial growth. The 16S rDNA sequencing confirmed the isolate as Enterobacter cloacae which was designated as DDB I...
May 22, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28568892/patch-testing-in-patients-with-suspected-cosmetic-dermatitis-a-retrospective-study
#9
Taru Garg, Soumya Agarwal, Ram Chander, Aashim Singh, Pravesh Yadav
BACKGROUND: Growing use of cosmetics has led to an increase in the incidence of allergic contact dermatitis (ACD) to cosmetics. Patch testing helps to confirm allergy to cosmetics and pinpoint the exact offending allergens. AIMS AND OBJECTIVES: The study aimed to find the frequency of positive patch test reactions in cases with suspected ACD to cosmetics, and the common allergens responsible for it. METHODS: This is a retrospective record-based study of 58 patients, with suspected ACD to cosmetics, who had undergone patch testing with Indian standard series and Indian cosmetic and fragrance series from January 2013 to December 2015...
June 1, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28534001/frequency-of-acute-hepatitis-following-acute-paraphenylene-diamine-intoxication
#10
Rizwan Ishtiaq, Sadaf Shafiq, Ali Imran, Qazi Masroor Ali, Raheel Khan, Hassan Tariq, Daniyal Ishtiaq
INTRODUCTION: Paraphenylene diamine (PPD) ingestion is manifesting as one of the more common ways of committing suicide in Southern Punjab, Pakistan, especially Bahawalpur. PPD is an ingredient of a compound commonly known "Kala Pathar" which means "Black Stone" in Urdu. It is readily available in the market at low cost and is used to dye hair and fur. Its intoxication inhibits cellular oxidation and affects the muscles causing rhabdomyolysis. This leads to myoglobinuria followed by renal failure and edema of face and throat resulting in respiratory difficulty...
April 21, 2017: Curēus
https://www.readbyqxmd.com/read/28497629/the-attitude-of-patients-with-p-phenylenediamine-or-2-5-toluenediamine-contact-allergy-to-hair-dyeing
#11
Tatiana A Vogel, Thalina M Prins, Arie Dijkstra, Pieter-Jan Coenraads, Marie L A Schuttelaar
No abstract text is available yet for this article.
June 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28484754/dual-modal-imaging-guided-highly-efficient-photothermal-therapy-using-heptamethine-cyanine-conjugated-hyaluronic-acid-micelles
#12
Sanpeng Li, Zhihong Sun, Guanjun Deng, Xiaoqing Meng, Wenjun Li, Dapeng Ni, Jiali Zhang, Ping Gong, Lintao Cai
Targeted phototherapy and multi-modal imaging can effectively improve the therapeutic efficacy and reduce the side effects of theranostics. Herein, we constructed novel biocompatible cyanine dye IR808-conjugated hyaluronic acid nanoparticles (HAIR NPs) for photothermal therapy (PTT) with near-infrared fluorescence (FL) and photoacoustic (PA) dual-modal imaging. The nanoparticles formed stable nanostructures under aqueous conditions with uniform size distribution. The HAIR NPs were rapidly taken up by the human lung cancer cells A549 via CD44 (the hyaluronic acid receptor on the surface of tumor cells) receptor-mediated endocytosis...
May 30, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28465469/size-dependent-penetration-of-nanoemulsions-into-epidermis-and-hair-follicles-implications-for-transdermal-delivery-and-immunization
#13
Rui Su, Wufa Fan, Qin Yu, Xiaochun Dong, Jianping Qi, Quangang Zhu, Weili Zhao, Wei Wu, Zhongjian Chen, Ye Li, Yi Lu
Nanoemulsions have been widely applied to dermal and transdermal drug delivery. However, whether and to what depth the integral nanoemulsions can permeate into the skin is not fully understood. In this study, an environment-responsive dye, P4, was loaded into nanoemulsions to track the transdermal translocation of the nanocarriers, while coumarin-6 was embedded to represent the cargoes. Particle size has great effects on the transdermal transportation of nanoemulsions. Integral nanoemulsions with particle size of 80 nm can diffuse into but not penetrate the viable epidermis...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28463045/mitigation-of-epidermal-growth-factor-receptor-inhibitor-induced-side-effects-utilizing-melanin-and-vascular-specific-lasers-a-case-report-series
#14
Karen Y Kuo, Bernice Kwong, Zakia Rahman
The advent of targeted chemotherapy has led to the emergence of new dermatologic toxicities. We sought to use lasers and light devices to treat recalcitrant cutaneous adverse effects related to cancer treatment. Three stage III or IV cancer patients with cutaneous complications due to epidermal growth factor receptor (EGFR) inhibitors were treated with melanin and vascular-specific laser and light technologies. Two patients reported reduction in papulopustular eruption following pulse dye laser (PDL) treatment...
March 2, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28459086/automated-tracking-of-root-for-confocal-time-lapse-imaging-of-cellular-processes
#15
Mehdi Doumane, Claire Lionnet, Vincent Bayle, Yvon Jaillais, Marie-Cécile Caillaud
Here we describe a protocol that enables to automatically perform time-lapse imaging of growing root tips for several hours. Plants roots expressing fluorescent proteins or stained with dyes are imaged while they grow using automatic movement of the microscope stage that compensates for root growth and allows to follow a given region of the root over time. The protocol makes possible the image acquisition of multiple growing root tips, therefore increasing the number of recorded mitotic events in a given experiment...
April 20, 2017: Bio-protocol
https://www.readbyqxmd.com/read/28436299/mgmt-gene-variants-temozolomide-myelotoxicity-and-glioma-risk-a-concise-literature-survey-including-an-illustrative-case
#16
Meric A Altinoz, Ilhan Elmaci, Fatih Han Bolukbasi, Cumhur Gokhan Ekmekci, Guven Yenmis, Ramazan Sari, Aydin Sav
Temozolomide may cause thrombocytopenia or neutropenia in 3-4% of glioblastoma patients, respectively. However, pancytopenia is rarely reported. MGMT (O6-methylguanine-DNA-methyltransferase) enzyme repairs temozolomide-induced DNA mutations and associates both with antitumour efficacy and myelosuppression. Many studies on the effects of MGMT gene-methylation on temozolomide's effects exist, but much fewer publications concerning MGMT variants were documented. A full sequencing of the MGMT gene was performed in a female glioblastoma patient, who developed pancytopenia following temozolomide treatment...
April 23, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28425114/a-multi-institutional-joint-study-of-contact-dermatitis-related-to-hair-colouring-and-perming-agents-in-japan
#17
Akiko Ito, Kazue Nishioka, Hiromi Kanto, Akiko Yagami, Shigeki Yamada, Mariko Sugiura, Chihiro Yasunaga, Keiko Yoshii, Hiromi Kobayashi, Atsuko Adachi, Yuko Ikezawa, Kumiko Washizaki, Shigeki Inui, Hitoshi Miyazawa, Naoki Oiso, Tokio Nakata, Kayoko Matsunaga
BACKGROUND: In Japan, allergic contact dermatitis caused by hair colouring agents is a considerable problem for those occupationally exposed and also for consumers. Over the last 20 years, p-phenylenediamine (PPD) has been a common allergen, with ∼7% positive patch test reactions. OBJECTIVES: To investigate which ingredients caused allergic contact dermatitis related to hair dye and perming solutions in Japan, to assess whether PPD is suitable for screening for hair dye allergy, and to propose allergens for a Japanese hairdresser series...
April 20, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28415435/developing-an-electrochemical-sensor-based-on-a-carbon-paste-electrode-modified-with-nano-composite-of-reduced-graphene-oxide-and-cufe2o4-nanoparticles-for-determination-of-hydrogen-peroxide
#18
Ali Benvidi, Mohammad Taghi Nafar, Shahriar Jahanbani, Marzieh Dehghan Tezerjani, Masoud Rezaeinasab, Sudabeh Dalirnasab
In this paper, a highly sensitive voltammetric sensor based on a carbon paste electrode with CuFe2O4 nanoparticle (RGO/CuFe2O4/CPE) was designed for determination of hydrogen peroxide (H2O2). The electrocatalytic reduction of H2O2 was examined using various techniques such as cyclic voltammetry (CV), chronoamperometry, amperometry and differential pulse voltammetry (DPV). CuFe2O4 nanoparticles were synthesized by co-precipitation method and characterized with scanning electron microscopy (SEM), Transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) techniques...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28407398/influence-of-bleaching-and-coloring-on-ethyl-glucuronide-content-in-human-hair
#19
Silvana Petzel-Witt, Werner Pogoda, Cora Wunder, Alexander Paulke, Manfred Schubert-Zsilavecz, Stefan W Toennes
Ethyl glucuronide (EtG) is increasingly used in forensic toxicology as marker for alcohol use in analyses of hair samples especially in abstinence control. Some cosmetic treatments are considered to markedly reduce the EtG content. In view of especially many women with colored hair the present study was performed to further investigate the effect of a variety of coloring procedures (bleaching, tinting, permanent and semi-permanent dyeing, henna) on the EtG content. Untreated hair samples (n = 12, EtG 13...
April 13, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28401988/a-rapid-nuclear-staining-test-using-cationic-dyes-contributes-to-efficient-str-analysis-of-telogen-hair-roots
#20
So-Yeon Lee, Eun-Ju Ha, Seung-Kyun Woo, So-Min Lee, Kyung-Hee Lim, Yong-Bin Eom
Telogen hairs presented in the crime scene are commonly encountered as trace evidence. However, short tandem repeat (STR) profiling of the hairs currently have low and limited use due to poor success rate. To increase the success rate of STR profiling of telogen hairs, we developed a rapid and cost-effective method to estimate the number of nuclei in the hair roots. Five cationic dyes, Methyl green (MG), Harris hematoxylin (HH), Methylene blue (MB), Toluidine blue (TB), and Safranin O (SO) were evaluated in this study...
July 2017: Electrophoresis
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