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paraphenylene diamine

Salma Tanweer, Mehwish Saeed, Saira Zaidi, Wasif Aslam
OBJECTIVE: To determine the clinical presentation, complications, and outcome of paraphenylene diamine (PPD) poisoning in patients presenting to Nishtar Hospital, Multan. STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Medical Unit II and III, Nishtar Hospital, Multan, from April 2015 to September 2016. METHODOLOGY: All adult patients admitted with history of paraphenylene diamine ingestion were evaluated for clinical features, complications, and outcomes on a pre-designed proforma...
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Carolina Mann, Fabian Anders, Hanhan Liu, Katrin Brockhaus, Aiwei Liu, Franz H Grus, Norbert Pfeiffer, Solon Thanos, Verena Prokosch
INTRODUCTION: Glaucoma is characterised by progressive loss of retinal ganglion cells and axons. Experimental research has concentrated on understanding the pathophysiological mechanisms involved in glaucomatous damage. It is still a matter of debate whether neurons or capillaries are primarily damaged by elevated intraocular pressure (IOP). The aim of this study was to detect IOP-induced vascular changes in the vessels of the optic nerve head and the main vessels of the retina in vivo...
March 28, 2018: Klinische Monatsblätter Für Augenheilkunde
Muhammad Ahmed Khan, Sumera Akram, Hassan Bin Usman Shah, Syed Abdul Mannan Hamdani, Muhammad Khan
OBJECTIVE: To assess cases of the spectrum of Kala Patharpoisoning in all age groups. STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Combined Military Hospital (CMH) Bahawalpur and Bahawal Victoria Hospital (BVH), Bahawalpur, from January 2016 to April 2017. METHODOLOGY: All the cases of Kala Pathar(Paraphenylene diamine (PPD)) poisoning, admitted and treated at the study places during said period were included in the study...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
P Elsner, S Schliemann
BACKGROUND: Cosmetic products are subject to the European Cosmetics Regulation: They shall not harm human health when used under "normal or reasonably foreseeable conditions". Hazardous cosmetic products are reported by the EU Member States to the EU Commission and are listed in the database of the European Rapid Alert System RAPEX. MATERIAL AND METHODS: The reports from Germany on dangerous cosmetic products from the years 2005-3/2017 in the European RAPEX database were systematically analyzed...
November 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Rizwan Ishtiaq, Sadaf Shafiq, Ali Imran, Qazi Masroor Ali, Raheel Khan, Hassan Tariq, Daniyal Ishtiaq
INTRODUCTION: Paraphenylene diamine (PPD) ingestion is manifesting as one of the more common ways of committing suicide in Southern Punjab, Pakistan, especially Bahawalpur. PPD is an ingredient of a compound commonly known "Kala Pathar" which means "Black Stone" in Urdu. It is readily available in the market at low cost and is used to dye hair and fur. Its intoxication inhibits cellular oxidation and affects the muscles causing rhabdomyolysis. This leads to myoglobinuria followed by renal failure and edema of face and throat resulting in respiratory difficulty...
April 21, 2017: Curēus
A S Bhagavathula
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Muthu Sendhil Kumaran, Tarun Narang, Davinder Parsad
A 45-year old woman presented with a 2-day history of intensely itchy, erythematous wheals over her scalp and around her eyes, ears, and front of the chest. She had applied hair color and immediately developed hives on the scalp, face, and chest with rhinitis and redness in the eyes. The lesions recovered within a half hour of taking a cetirizine 10-mg tablet. She gave a similar history around three times in the past 6 months. She used a different brand of hair color every time but all were associated with the same symptoms...
2016: Skinmed
(no author information available yet)
[This retracts the article on p. 199 in vol. 3, PMID: 23225987.].
July 2016: Journal of Natural Science, Biology, and Medicine
Younes Zaid, Fatimazahra Marhoume, Nezha Senhaji, Kevin Kojok, Hicham Boufous, Abdallah Naya, Mounia Oudghiri, Youssef Darif, Norddine Habti, Soukaina Zouine, Fekhaoui Mohamed, Abderahmane Chait, Abdellah Bagri
Paraphenylene daimine (PPD) is an aromatic amine that is widely used in several industrial products; however, its toxicity has been reported in several cases of cardiac arrests. As platelets play a key role in cardiovascular diseases, we aimed to determine the impact of PPD in vitro and in vivo on platelet function. Our findings demonstrated that platelet activation and aggregation were strongly enhanced by PPD. Treatment with PPD primed human platelets that became more reactive in response to low doses of collagen...
February 2016: Journal of Toxicological Sciences
Satish Mendonca, Satish Barki, Mayank Mishra, R S V Kumar, Devika Gupta, Pooja Gupta
We present a young lady who consumed hair dye, which contained paraphenylene diamine (PPD), as a means of deliberate self-harm. This resulted in severe angio-neurotic edema for which she had to be ventilated, and thereafter developed rhabdomyolysis leading to acute kidney injury (AKI). The unusual aspect was that the patient continued to have flaccid quadriparesis and inability to regain kidney function. Renal biopsy performed 10 weeks after the dye consumption revealed severe acute tubular necrosis with myoglobin pigment casts...
September 2015: Saudi Journal of Kidney Diseases and Transplantation
Rubina Naqvi, Fazal Akhtar, Uzma Farooq, Sumaira Ashraf, Syed Adibul Hasan Rizvi
AIM: We report here, a case series of patients with acute kidney injury (AKI) after ingestion of paraphenylene diamine (PPD) a derivative of analine. It is used as a colouring agent to dye hair, fur and plastic and in photographic films. METHODS: Subjects for the study reported here comprised a cohort of 100 patients coming to this institution with AKI following PPD poisoning. AKI was defined according to RIFLE criteria and PPD poisoning on the basis of history and presenting features...
December 2015: Nephrology
Laura H Eaton, Ruth A Roberts, Ian Kimber, Rebecca J Dearman, Aleksandra Metryka
Upon antigen/allergen recognition, epidermal Langerhans' cells (LC) are mobilized and migrate to the local lymph node where they play a major role in initiating or regulating immune responses. It had been proposed that all chemical allergens induce LC migration via common cytokine signals delivered by TNF-α and IL-1β. Here the dependence of LC migration on TNF-α following treatment of mice with various chemical allergens has been investigated. It was found that under standard conditions the allergens oxazolone, paraphenylene diamine, and trimellitic anhydride, in addition to the skin irritant sodium lauryl sulfate, were unable to trigger LC mobilization in the absence of TNF-α signalling...
January 2015: Immunology
P K Jain, Awadhesh Kumar Sharma, Navneet Agarwal, Praveen Kumar Jain, N S Sengar, Nutan Agarwal, Mohd Zaki Siddiqui, Praveen Pawal, Anurag Kumar Singh, Ripu Daman Gaba
BACKGROUND: Myocarditis is a unheard and unreported dangerous complication of hair dye ingestion which contains paraphenylene diamine. So a prospective study was planned to assess myocardial damage in regard to clinical profile and outcome with different treatment approaches in patients with oral ingestion of Hair dye. METHODS AND RESULTS: The material comprised of 1595 cases admitted in Medicine Department of Maharani Laxmi Bai Medical College, Jhansi, Uttar Pradesh-INDIA, from July 2004 to Jan 2011...
September 2013: Journal of the Association of Physicians of India
Eva Helaskoski, Hille Suojalehto, Hannele Virtanen, Liisa Airaksinen, Outi Kuuliala, Kristiina Aalto-Korte, Maria Pesonen
BACKGROUND: Oxidative hair dyes commonly contain paraphenylene diamine (PPD) and its derivatives, a well-known cause of delayed hypersensitivity among both consumers and hairdressers. They are also considered possible causes of occupational respiratory diseases. Despite the widespread use of hair dyes, there are only a few reports of asthma, rhinitis, and contact urticaria caused by PPD and related compounds. OBJECTIVE: To characterize patients with occupational asthma, rhinitis, or contact urticaria associated with oxidative hair dyes and to evaluate the diagnostic methods...
January 2014: Annals of Allergy, Asthma & Immunology
Murat Elevli, Mahmut Civilibal, Ozlem Ersoy, Demet Demirkol, Ahmet Hakan Gedik
Paraphenylene daimine (PPD) is a kind of aromatic amine that is widely used in several industrial products. Women also use PPD added to henna (Lawasonia alba) as a hair dye. Though rare in Western countries, PPD poisoning is quite common in East Africa, India and Middle Eastern countries because it is a traditional product at these countries. Different pathologies were described as caused by PPD ingestion including angioedema of head and neck, rhabdomyolysis, and acute renal failure. The authors report a case of systemic poisoning with PPD that lead to angioedema resulting in tracheostomy and rhabdomyolysis...
July 2014: Indian Journal of Pediatrics
Esin Güner, Göknur Kalkan, Ekşioğlu Meral, Murat Baykır
BACKGROUND: The onset and exacerbations of discoid lupus erythematosus (DLE) can be precipitated by several factors like needling, scratches, trauma, X-rays, heat, cold, pressure, tattooing, scars, allergic and irritant dermatitis and inflammatory dermatoses. OBJECTIVE: To investigate the role of allergic contact dermatitis (ACD) in devolopment and triggering of the lesions of DLE. MATERIALS AND METHODS: This study was performed on 30 patients with DLE...
September 2013: Cutaneous and Ocular Toxicology
A C Jesudoss Prabhakaran
The commonest constituent of all hair dyes is paraphenylene diamine (PPD) being used by the people to color their hair all over the world. Hair dye poisoning is emerging as one of the emerging causes of intentional self-poisoning to commit suicide. In this article, the importance of clinical manifestations and of hair dye poisoning is discussed due to the lack of specific diagnostic tests. Since there is no specific antidote for PPD poisoning, the early supportive treatment modalities are discussed.
July 2012: Journal of Natural Science, Biology, and Medicine
Mohamed Babikir Abdelraheem, Mohamed Elbushra, El-Tigani Ali, Rashid A Ellidir, Amna I Bushara, Waleed B Abdelraheem, Eduard E Zijlstra
Paraphenylene diamine (PPD) hair dye poisoning is a common health problem in the Middle East and Indian subcontinent. It is the most common cause of suicide intent especially among females. We hereby present a 27-year-old female who presented with a clinical feature of PPD poisoning due to a suicidal attempt, and she died soon after arrival. She had survived a previous suicide attempt with PPD 4 years before. This time she also intentionally tried to kill her four children using PPD. One child died, one recovered after dialysis for acute kidney injury and the other two survived without any further intervention...
September 2014: Toxicology and Industrial Health
Yassir Bousliman, Rachid Eljaoudi, Mina Ait Elcadi, Thiery Basset, Jean-Pierre Gay-Montchamp, Amine Ali Zeggwagh, Abdelaziz Bouklouze, Yahia Cherrah, Michel Ollagnier
Paraphenylenediamine is an aromatic amine used as a hair dye; it is responsible for poisoning characterized by respiratory distress involving life-threatening. The objective of this work is the development and validation of an assay of para-phenylenediamine in the whole blood. The method is based on the determination of paraphenylene diamine in whole blood by gas chromatography-mass spectrometry after liquid-liquid extraction and derivatization. The validation protocol has included the study of the recovery factor of extraction, the measurement range, accurency, repetability and intermediate precision...
November 2012: Annales de Biologie Clinique
Sankha Koley, Jyotirindranath Sarkar, Sanjiv Choudhary, Suparna Dhara, Manoj Choudhury
Erythema multiforme (EM) is an acute mucocutaneous hypersensitivity reaction with varying degrees of blistering and ulceration. Common causes of EM are herpes simplex virus infection, mycoplasma infection, drug hypersensitivity, vaccination and drug-virus interaction. EM induced by contact dermatitis is rare. Paraphenylene diamine, a common ingredient in many hair dyes, is well known to produce allergic contact dermatitis. We report a 35-year-old lady presenting with EM following severe contact dermatitis to hair dye...
May 2012: Indian Journal of Dermatology
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