Younes Zaid, Fatimazahra Marhoume, Nezha Senhaji, Kevin Kojok, Hicham Boufous, Abdallah Naya, Mounia Oudghiri, Youssef Darif, Norddine Habti, Soukaina Zouine, Fekhaoui Mohamed, Abderahmane Chait, Abdellah Bagri
Paraphenylene daimine (PPD) is an aromatic amine that is widely used in several industrial products; however, its toxicity has been reported in several cases of cardiac arrests. As platelets play a key role in cardiovascular diseases, we aimed to determine the impact of PPD in vitro and in vivo on platelet function. Our findings demonstrated that platelet activation and aggregation were strongly enhanced by PPD. Treatment with PPD primed human platelets that became more reactive in response to low doses of collagen...
February 2016: Journal of Toxicological Sciences