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https://www.readbyqxmd.com/read/29457498/factors-associated-with-maternal-depression-in-the-maldives-a-prospective-cohort-study
#1
R Abdul Raheem, Hui J Chih, Colin W Binns
The aim of the study was to document perinatal depression in mothers in the Maldives and associated factors. A cohort of 458 mothers was recruited at the 2 major hospitals in Malé, the Maldives, and followed from 36 weeks of pregnancy to 3 months after birth. The Edinburgh Postnatal Depression Scale (EPDS) was used to measure maternal depression. Maternal sociodemographic factors and infant's health were also recorded. The prevalence of depressive symptoms (EPDS score ≥13) at 36 weeks of pregnancy and at 1 and 3 months postpartum were 24%, 27%, and 12%, respectively...
February 1, 2018: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/29454341/treatment-of-depression-with-chai-hu-shu-gan-san-a-systematic-review-and-meta-analysis-of-42-randomized-controlled-trials
#2
Yan Sun, Xia Xu, Jinping Zhang, Yuanyuan Chen
BACKGROUND: Depression is a common mental disorder. Chai Hu Shu Gan San, a traditional Chinese medicine, is used to treat depression empirically. We present a systematic review and meta-analysis of the therapeutic efficacy and safety of Chai Hu Shu Gan San in treating depression. METHODS: Several databases, including PubMed, China National Knowledge Internet, Wanfang, Chongqing VIP, and the Cochrane library, were systematically searched from their date of foundation to January 1, 2017...
February 17, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29453442/white-matter-integrity-in-medication-free-women-with-peripartum-depression-a-tract-based-spatial-statistics-study
#3
Michelle Silver, Constance M Moore, Vanessa Villamarin, Nina Jaitly, Janet E Hall, Anthony J Rothschild, Kristina M Deligiannidis
Diffusion tensor imaging (DTI) studies in depression show decreased structural connectivity in the left anterior limb of the internal capsule and the genu of the corpus callosum but no such studies exist in peripartum depression (PPD), which affects 1 in 8 women. We analyzed fractional anisotropy (FA) as a measure of white matter integrity of these two tracts using tract-based spatial statistics (TBSS). We then conducted an exploratory whole-brain analysis to identify additional regions implicated in PPD. Seventy-five pregnant, medication-free women were evaluated with the Edinburgh Postnatal Depression Scale (EPDS) and Structured Clinical Interview (SCID) for DSM-IV-TR in pregnancy and in the postpartum...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29452045/successful-treatment-of-schamberg-s-disease-with-fractional-non-ablative-1540-nm-erbium-glass-laser
#4
Yuval Hilerowicz, Eli Sprecher, Andrea Gat, Ofir Artzi
Schamberg's disease is one of the pigmented purpuric dermatoses (PPD). PPD encompass a large and heterogeneous group of dermatologic disorders featuring purpuric lesions often located on the lower limbs. The various forms of PPD are notoriously known to be resistant to treatment. Fractional photothermolysis has been described as a successful and safe method to induce dermal remodeling. We report three patients with Schamberg's disease who were successfully treated with 4 monthly sessions of fractional non-ablative 1540 nm erbium:glass laser, with resolution of their purpuric pigmented rash lasting up to 9 months after the last treatment session...
February 16, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29449122/non-pharmacological-interventions-for-improving-postpartum-maternal-sleep-a-systematic-review-and-meta-analysis
#5
REVIEW
Sawayra Owais, Cheryl H T Chow, Melissa Furtado, Benicio N Frey, Ryan J Van Lieshout
Evidence suggests that poor postpartum sleep quality is a risk factor for the development of postpartum depression. As such, non-pharmacological interventions have been developed to help improve sleep in the postpartum period. The primary aims of this systematic review and meta-analysis were to determine if non-pharmacological interventions improved maternal sleep and to compare the effectiveness of different intervention types. Secondary aims included examining effects on maternal mood and infant sleep. We searched MEDLINE, EMBASE, CINAHL, PsycINFO, and Web of Science from their inceptions to September 2017 and found 15 eligible studies...
January 31, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29444165/frequency-trends-and-antecedents-of-severe-maternal-depression-after-three-million-u-s-births
#6
Urbano L França, Michael L McManus
BACKGROUND: Postpartum depression carries adverse consequences for mothers and children, so widespread screening during primary care visits is recommended. However, the rates, timing, and factors associated with significant depressive episodes are incompletely understood. METHODS AND FINDINGS: We examined the Healthcare Cost and Utilization Project (HCUP) State Inpatient, Emergency Department, and Ambulatory Surgery and Services Databases from California (2005-2011) and Florida (2005-2012)...
2018: PloS One
https://www.readbyqxmd.com/read/29444162/low-serum-levels-of-high-density-lipoprotein-cholesterol-hdl-c-as-an-indicator-for-the-development-of-severe-postpartum-depressive-symptoms
#7
Raji Ramachandran Pillai, Anand Babu Wilson, Nancy R Premkumar, Shivanand Kattimani, Haritha Sagili, Soundravally Rajendiran
Postpartum depression (PPD) is a psychiatric complication of childbirth affecting 10-20% of new mothers and has negative impact on both mother and infant. Serum lipid levels have been related to depressive disorders, but very limited literatures are available regarding the lipid levels in women with postpartum depression. The present study is aimed to examine the association of serum lipids with the development of postpartum depressive symptoms. This is a cross sectional study conducted at a tertiary care hospital in South India...
2018: PloS One
https://www.readbyqxmd.com/read/29440791/obesity-and-oral-health-is-there-a-link-an-observational-study
#8
Neeraj Chandrahas Deshpande, Mansi Rajendrakumar Amrutiya
Introduction: Periodontitis is defined as a destructive inflammatory disease involving the supporting tissues of the teeth due to specific microorganisms which results in a progressive destruction of supporting structures of the periodontium. Obesity is excessive body fat in proportion to lean body mass, to such an extent that health is impaired. Obesity, a serious public health problem, relates to a chronic low-grade systemic inflammation and is involved in the development of obesity-linked disorders including insulin resistance, type 2 diabetes, cardiovascular diseases, dyslipidemia, and metabolic syndrome...
May 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29439944/digital-peer-support-platform-7cups-as-an-adjunct-treatment-for-women-with-postpartum-depression-feasibility-acceptability-and-preliminary-efficacy-study
#9
Amit Baumel, Amanda Tinkelman, Nandita Mathur, John M Kane
BACKGROUND: Peer support is considered to be an important framework of support for mothers experiencing postpartum depression (PPD); however, some barriers exist that may limit its use including peer availability and mothers' lack of time due to child care. OBJECTIVE: This non-randomized study was designed to examine the feasibility, acceptance, and preliminary clinical outcomes of using 7 Cups of Tea (7Cups), a digital platform that delivers self-help tools and 24/7 emotional support delivered by trained volunteers, as an adjunct treatment for mothers diagnosed with PPD...
February 13, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29436333/effect-of-singing-interventions-on-symptoms-of-postnatal-depression-three-arm-randomised-controlled-trial
#10
D Fancourt, R Perkins
This study assessed whether a novel psychosocial intervention could reduce symptoms of postnatal depression (PND) in the first 40 weeks post-birth. Analyses were carried out of 134 mothers with symptoms of PND randomised into 10 weeks of group singing workshops or group play workshops for them and their babies, or usual care (trial registration: NCT02526407). Overall, among all mothers with symptoms of PND, there was a non-significant faster improvement in symptoms in the singing group (F 4,262 = 1.66, P = 0...
February 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29435785/adverse-childhood-experiences-and-postpartum-depression-in-home-visiting-programs-prevalence-association-and-mediating-mechanisms
#11
Joshua P Mersky, Colleen E Janczewski
Objectives In this study, we examined the prevalence of postpartum depression (PPD) and its association with select demographic factors and antenatal conditions. We also investigated whether greater exposure to adverse childhood experiences (ACEs) is associated with PPD, and if antenatal conditions mediate the ACE-PPD relationship. Methods Data were collected from 735 low-income women receiving home visiting services. Descriptive and bivariate analyses provided estimates of PPD and its correlates, and nested path analyses were used to test for mediation...
February 12, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29434714/20-s-protopanaxadiol-induces-apoptosis-in-human-hepatoblastoma-hepg2-cells-by-downregulating-the-protein-kinase-b-signaling-pathway
#12
Zeyuan Lu, Huali Xu, Xiaofeng Yu, Yuchen Wang, Long Huang, Xin Jin, Dayun Sui
Hepatoblastoma is the most common primary liver tumor for children aged <5 years old. 20(S)-Protopanaxadiol (PPD) is a ginsenoside extracted from Pananx quinquefolium L., which inhibits tumor growth in several cancer cell lines. The purpose of the present study was to assess the anticancer activities of 20(S)-PPD in human hepatoblastoma HepG2 cells. The cytotoxicity of 20(S)-PPD on HepG2 cells was evaluated using an MTT assay. Apoptosis was detected using DAPI staining and flow cytometry. The expression of apoptosis-associated proteins was identified by western blotting...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434401/point-of-care-tuberculosis-sero-diagnosis-kit-for-wild-animals-combination-of-proteins-for-improving-the-diagnostic-sensitivity-and-specificity
#13
Maroudam Veerasami, K Venkataraman, Chitra Karuppannan, Arun Attur Shanmugam, Mallepaddi Chand Prudhvi, Thomas Holder, Polavarapu Rathnagiri, K Arunmozhivarman, Gopal Dhinakar Raj, Martin Vordermeier, B Mohana Subramanian
Tuberculosis is a significant problem globally for domestic animals as well as captive and free ranging wild life. Rapid point of care (POC) serology kits are well suited for the diagnosis of TB in wild animals. However, wild animals are invariably exposed to environmental non-pathogenic mycobacterium species with the development of cross reacting antibodies. In the present study, POC TB diagnosis kit was developed using a combination of pathogenic Mycobacteria specific recombinant antigens and purified protein derivatives of pathogenic and non-pathogenic Mycobacteria...
March 2018: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29433610/accuracy-of-the-whooley-questions-and-the-edinburgh-postnatal-depression-scale-in-identifying-depression-and-other-mental-disorders-in-early-pregnancy
#14
Louise Michele Howard, Elizabeth G Ryan, Kylee Trevillion, Fraser Anderson, Debra Bick, Amanda Bye, Sarah Byford, Sheila O'Connor, Polly Sands, Jill Demilew, Jeannette Milgrom, Andrew Pickles
BACKGROUND: There is limited evidence on the prevalence and identification of antenatal mental disorders. Aims To investigate the prevalence of mental disorders in early pregnancy and the diagnostic accuracy of depression-screening (Whooley) questions compared with the Edinburgh Postnatal Depression Scale (EPDS), against the Structured Clinical Interview DSM-IV-TR. METHOD: Cross-sectional survey of women responding to Whooley questions asked at their first antenatal appointment...
January 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29432494/correction-heritable-heading-time-variation-in-wheat-lines-with-the-same-number-of-ppd-b1-gene-copies
#15
Zuzana Ivaničová, Miroslav Valárik, Kateřina Pánková, Martina Trávníčková, Jaroslav Doležel, Jan Šafář, Zbyněk Milec
[This corrects the article DOI: 10.1371/journal.pone.0183745.].
2018: PloS One
https://www.readbyqxmd.com/read/29431859/adverse-childhood-experiences-and-depressive-symptomatology-among-pregnant-women
#16
Katja Ångerud, Eva-Maria Annerbäck, Tanja Tydén, Santosh Boddeti, Per Kristiansson
INTRODUCTION: Adverse childhood experiences (ACE) result in somatic and mental health disturbances. Its influence on antenatal depression is scarcely studied. This study examined the association between experience of ACE and antenatal depressive symptomatology. MATERIAL AND METHODS: 1257 women from 172 antenatal clinics in Sweden were surveyed during pregnancy and one year after delivery. Demographics, previous medical history and Edinburgh Postpartum Depression Scale (EPDS) were collected in pregnancy and postpartum and ACE one year postpartum...
February 12, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29429990/non-canonical-activation-of-hedgehog-in-prostate-cancer-cells-mediated-by-the-interaction-of-transcriptionally-active-androgen-receptor-proteins-with-gli3
#17
Na Li, Sarah Truong, Mannan Nouri, Jackson Moore, Nader Al Nakouzi, Amy Anne Lubik, Ralph Buttyan
Hedgehog (Hh) is an oncogenic signaling pathway that regulates the activity of Gli transcription factors. Canonical Hh is a Smoothened- (Smo-) driven process that alters the post-translational processing of Gli2/Gli3 proteins. Though evidence supports a role for Gli action in prostate cancer (PCa) cell growth and progression, there is little indication that Smo is involved. Here we describe a non-canonical means for activation of Gli transcription in PCa cells mediated by the binding of transcriptionally-active androgen receptors (ARs) to Gli3...
February 12, 2018: Oncogene
https://www.readbyqxmd.com/read/29429056/histological-healing-after-nonsurgical-periodontal-treatment-with-enamel-matrix-derivatives-in-canine-experimental-periodontitis
#18
Ammar Shujaa Addin, Tatsuya Akizuki, Takanori Matsuura, Shu Hoshi, Takahiro Ikawa, Kiichi Maruyama, Wataru Ono, Shunsuke Fukuba, Yuichi Izumi
The histological outcomes after nonsurgical periodontal treatment with enamel matrix derivatives (EMD) remain controversial. The present study evaluated periodontal wound healing after scaling and root planing (SRP) with subgingival application of EMD for treatment of experimental periodontitis. Periodontal breakdown was induced by applying silk ligatures around mandibular third and fourth premolars of six beagle dogs until radiographic bone loss progressed to approximately half of the root length. Probing pocket depth (PPD) and clinical attachment level (CAL) were proximally measured 2 weeks after ligature removal (baseline)...
February 10, 2018: Odontology
https://www.readbyqxmd.com/read/29428520/stress-and-symptoms-of-depression-in-fathers-of-infants-admitted-to-the-nicu
#19
Helen Cyr-Alves, Lynn Macken, Kristiina Hyrkas
OBJECTIVE: To describe perceived stress and symptoms of depression in fathers of infants admitted to the NICU through 2 months after discharge and to explore associations between fathers' childhoods and current relationships with their own parents and their stress and symptoms of depression. DESIGN: Observational, longitudinal. SETTING: Tertiary care center in northeastern United States. PARTICIPANTS: English-speaking fathers of newborns admitted to the NICU...
February 8, 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29428196/evaluation-of-cellular-immunogenicity-of-recombinant-cytochrome-p450-cyp141-protein-of-mycobacterium-tuberculosis-in-human-and-mouse-model
#20
Mahshid Salehi, Rahman Abdizadeh, Batoul Pourgheysari, Behnam Zamanzad, Amin Soltani, Abolfazl Gholipour, Reza Heidari
Mycobacterium tuberculosis (Mtb) is still considered one of the unsolved problems for the World Health Organization Identifying and selecting an immunogenic antigen capable of generating specific immune responses is generally the goal of all studies being carried out in to designing new vaccines. Accordingly, the present study was conducted to evaluate the immunogenicity of a M. tuberculosis recombinant protein which exist in the regions of the bacterium genome and may be an immunogenic protein. Immunogenicity of purified proteins was measured by PBMC and mouse spleen lymphocytes culturing methods using ELISA after an appropriate amount of time of incubation with Recombinant cytochrome P450 CYP141 protein...
February 7, 2018: Biologicals: Journal of the International Association of Biological Standardization
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